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https://www.readbyqxmd.com/read/28343075/an-update-on-application-of-nanotechnology-and-stem-cells-in-spinal-cord-injury-regeneration
#1
REVIEW
Kazem Nejati-Koshki, Yousef Mortazavi, Younes Pilehvar-Soltanahmadi, Sumit Sheoran, Nosratollah Zarghami
Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. The pathophysiological advancement of SCI is divided into two categories: primary injury and secondary injury. Due to the loss of motor, sensory, or cognitive function, a patient's quality of life is likely reduced and places a great burden on society in order to supply health care costs. Therefore, it is important to develop suitable therapeutic strategies for SCI therapy...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28335352/nano-biosensor-for-monitoring-the-neural-differentiation-of-stem-cells
#2
REVIEW
Jin-Ho Lee, Taek Lee, Jeong-Woo Choi
In tissue engineering and regenerative medicine, monitoring the status of stem cell differentiation is crucial to verify therapeutic efficacy and optimize treatment procedures. However, traditional methods, such as cell staining and sorting, are labor-intensive and may damage the cells. Therefore, the development of noninvasive methods to monitor the differentiation status in situ is highly desirable and can be of great benefit to stem cell-based therapies. Toward this end, nanotechnology has been applied to develop highly-sensitive biosensors to noninvasively monitor the neural differentiation of stem cells...
November 28, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#3
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335186/ex-vivo-tissues-engineering-modeling-for-reconstructive-surgery-using-human-adult-adipose-stem-cells-and-polymeric-nanostructured-matrix
#4
Francesco Morena, Chiara Argentati, Eleonora Calzoni, Marino Cordellini, Carla Emiliani, Francesco D'Angelo, Sabata Martino
The major challenge for stem cell translation regenerative medicine is the regeneration of damaged tissues by creating biological substitutes capable of recapitulating the missing function in the recipient host. Therefore, the current paradigm of tissue engineering strategies is the combination of a selected stem cell type, based on their capability to differentiate toward committed cell lineages, and a biomaterial, that, due to own characteristics (e.g., chemical, electric, mechanical property, nano-topography, and nanostructured molecular components), could serve as active scaffold to generate a bio-hybrid tissue/organ...
March 31, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334693/fabrication-of-human-hair-keratin-jellyfish-collagen-eggshell-derived-hydroxyapatite-osteoinductive-biocomposite-scaffolds-for-bone-tissue-engineering-from-waste-to-regenerative-medicine-products
#5
Yavuz Emre Arslan, Tugba Sezgin Arslan, Burak Derkus, Emel Emregul, Kaan C Emregul
In the present study, we aimed at fabricating an osteoinductive biocomposite scaffold using keratin obtained from human hair, jellyfish collagen and eggshell-derived nano-sized spherical hydroxyapatite (nHA) for bone tissue engineering applications. Keratin, collagen and nHA were characterized with the modified Lowry method, free-sulfhydryl groups and hydroxyproline content analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and thermal gravimetric analysis (TGA) which confirmed the success of the extraction and/or isolation processes...
March 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28315912/an-imaging-target-tgf-%C3%AE-1-for-hepatocellular-carcinoma-in-mice
#6
Yiqiu Zhang, Beilei Li, Xiao Li, Hui Tan, Dengfeng Cheng, Hongcheng Shi
It has been reported that the positive detection rate of Fluorine-18-fluorodeoxyglucose ((18)F-FDG) metabolism in positron emission tomography (PET) imaging, for the diagnosis of hepatocellular carcinoma (HCC) is only about 50%. In particular, (18)F-FDG PET imaging is prone to false negative findings in HCC. Transforming growth factor-beta1 (TGF-β1) shows over expression rates in early HCC liver tissue growth and promotes tumor invasion and metastases. Our aim was to use In this study, we used the feasibility of iodine-125 ((125)I)-labeled TGF-β1 antibody as a nuclear medicine imaging target in HCC...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28302035/translational-multimodality-neuroimaging
#7
Sushil K Sharma
Recently high-resolution, noninvasive, multimodality in-vivo molecular imaging with PET, SPECT, CT and MRI, employing fusion algorithms has revolutionized personalized medicine. However, specific radiopharmaceuticals (RPs) for the accurate diagnosis and effective treatment of progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, drug addiction, and other cognitive impairments still remain in developmental phase. Currently, multimodality fusion neuroimaging is utilized for the determination of: pharmacokinetics and pre-clinical development of radiopharmaceuticals (RPs); in-vivo monitoring of stem cell transplantation therapy; nicotinic acetylcholine receptors (nAChRs) investigations; and regional cerebral blood flow and glucose metabolism in cognitively-impaired subjects employing noninvasive microPET and nano-SPECT imaging...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28300393/remote-control-and-modulation-of-cellular-events-by-plasmonic-gold-nanoparticles-implications-and-opportunities-for-biomedical-applications
#8
Jiayang Li, Jing Liu, Chunying Chen
Compared to traditional hyperthermia methods, gold nanoparticles (Au NPs) successfully achieve site-specific incremental temperature in deep tissues. By virtue of near-infrared (NIR) laser-mediated photothermal treatment, Au NPs have been widely explored in clinical and preclinical applications, including cancer therapy and tissue engineering. In this issue of ACS Nano, Suzuki, Ciofani, and colleagues demonstrate how gold nanoshells can remotely activate striated muscle cells via inducing myotube contraction and modulating related gene expression by mild heat stimulation under NIR irradiation...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28288456/from-technique-of-tattooing-to-biokinetics-and-toxicology-of-injected-tattoo-ink-particles-and-chemicals
#9
Jørgen Serup
Tattoo colourants are colourful nano- and microparticles, which are practically insoluble and thus permanent once installed in the dermis by the tattooist. Tattoo ink also has soluble ingredients and contaminants. Pigments can distribute via the lymph and possibly also directly to the blood, and a minute fraction may over time undergo metabolic breakdown and as hapten(s) induce allergic reactions of red tattoos. Carbon black of black tattoos has a tendency to agglomerate and form larger bodies that can elicit foreign body reactions in black tattoos and even granuloma formation with overlap to sarcoidosis in the clinic...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28275628/extracellular-vesicles-small-bricks-for-tissue-repair-regeneration
#10
COMMENT
Simona Taverna, Marzia Pucci, Riccardo Alessandro
Extracellular vesicles (EVs) are nano-sized membrane vesicles involved in intercellular communication. EVs have pleiotropic actions in physiological and pathological conditions. The ability of EVs to transports proteins, drugs and nucleic acid, to target specific cells and to increase the stability of therapeutic cargo, make EVs interesting as new devices for the treatment of human disease. In a recently published issue of European journal of pharmaceutical sciences, Silva and colleagues reviewed the ability of EVs to modulate tissue repair and regeneration, focusing on their roles and therapeutic potential as immunomodulatory messengers...
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28271478/symmetry-directed-design-of-protein-cages-and-protein-lattices-and-their-applications
#11
Aaron Sciore, E Neil G Marsh
The assembly of individual protein subunits into large-scale structures is important in many biological contexts. Proteins may assemble into geometrical cages or extended lattices that are characterized by a high degree of symmetry; examples include viral capsids and bacterial S-layers. The precisely defined higher order structure exhibited by these assemblies has inspired efforts to design such structures de novo by applying the principles of symmetry evident in natural protein assemblies. Here we discuss progress towards this goal and also examples of natural protein cages and lattices that have been engineered to repurpose them towards a diverse range of applications in materials science and nano-medicine...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28268943/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#12
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267316/advances-toward-more-efficient-targeted-delivery-of-nanoparticles-in-vivo-understanding-interactions-between-nanoparticles-and-cells
#13
Ester Polo, Manuel Collado, Beatriz Pelaz, Pablo Del Pino
In this Perspective, we describe current challenges and recent advances in efficient delivery and targeting of nanoparticles in vivo. We discuss cancer therapy, nanoparticle-biomolecule interactions, nanoparticle trafficking in cells, and triggers and responses to nanoparticle-cell interactions. No matter which functionalization strategy to target cancer is chosen, passive or active targeting, more than 99% of the nanoparticles administered in vivo end up in the mononuclear phagocytic system, mainly sequestered by macrophages...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28261169/the-disruption-of-an-oxyr-like-protein-impairs-intracellular-magnetite-biomineralization-in-magnetospirillum-gryphiswaldense-msr-1
#14
Yunpeng Zhang, Tong Wen, Fangfang Guo, Yuanyuan Geng, Junquan Liu, Tao Peng, Guohua Guan, Jiesheng Tian, Ying Li, Jilun Li, Jing Ju, Wei Jiang
Magnetotactic bacteria synthesize intracellular membrane-enveloped magnetite bodies known as magnetosomes which have been applied in biotechnology and medicine. A series of proteins involved in ferric ion transport and redox required for magnetite formation have been identified but the knowledge of magnetosome biomineralization remains very limited. Here, we identify a novel OxyR homolog (named OxyR-Like), the disruption of which resulted in low ferromagnetism and disfigured nano-sized iron oxide crystals. High resolution-transmission electron microscopy showed that these nanoparticles are mainly composed of magnetite accompanied with ferric oxide including α-Fe2O3 and ...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28256565/passion-fruit-like-nano-architectures-a-general-synthesis-route
#15
D Cassano, J David, S Luin, V Voliani
Noble metal nanostructures have demonstrated a number of intriguing features for both medicine and catalysis. However, accumulation issues have prevented their clinical translation, while their use in catalysis has shown serious efficiency and stability hurdles. Here we introduce a simple and robust synthetic protocol for passion fruit-like nano-architectures composed by a silica shell embedding polymeric arrays of ultrasmall noble metal nanoparticles. These nano-architectures show interesting features for both oncology and catalysis...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254569/synthesis-and-characterization-of-core-shell-bimetallic-nanoparticles-for-synergistic-antimicrobial-effect-studies-in-combination-with-doxycycline-on-burn-specific-pathogens
#16
Ali Fakhri, Shiva Tahami, Mahsa Naji
Nano-medicine is a breakthrough discovery in the healthcare sector. Doxycycline is a new generation antibiotic which is proved to be a boon in the treatment of patients with complicated skin infections. We have tried to explore the benefits of synthesized bimetallic silver-gold nanoparticles in combination with new generation antibiotic for burn infections. The bimetallic nanoparticles synthesized by core-shell method were characterized using scanning electron microscopy equipped with an energy dispersive spectrometer, transmission electron microscopy, X-ray diffraction and UV-Vis spectroscopy...
February 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28249242/phytofabricated-gold-nanoparticles-and-their-biomedical-applications
#17
REVIEW
Bashir Ahmad, Nabia Hafeez, Shumaila Bashir, Abdur Rauf, Mujeeb-Ur-Rehman
In a couple of decades, nanotechnology has become a trending technology owing to its integrated science collection that incorporates variety of fields such as chemistry, physics, medicine, catalytic processes, food processing industries, electronics and energy sectors. One of the emerging fields of nanotechnology that has gained momentous admiration is nano-biotechnology. Nano-biotechnology is an integrated combination of biology with nanotechnology that encompasses the tailoring, and synthesis of small particles that are less than 100nm in size and subsequent exploitation of these particles for their biological applications...
February 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28229593/development-of-laser-structured-liquid-infused-titanium-with-strong-biofilm-repellent-properties
#18
Katharina Doll, Elena Fadeeva, Joern Schaeske, Tobias Ehmke, Andreas Winkel, Alexander Heisterkamp, Boris N Chichkov, Meike Stiesch, Nico S Stumpp
Medical implants are commonly used in modern medicine but still harbor the risk of microbial infections caused by bacterial biofilms. As their retrospective treatment is difficult, there is a need for biomedical materials that inhibit bacterial colonization from the start without using antibacterial agents, as these can promote resistance development. The promising concept of slippery liquid-infused porous surfaces (SLIPS) possesses enormous potential for this purpose. In the present study, this principle was applied to titanium, a common material in implantology, and its biofilm-repellent properties were demonstrated...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28227149/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#19
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Marc-Andre Fortin, Eric Boilard, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219723/the-protective-effects-of-resveratrol-h2s-and-thermotherapy-on-the-cell-apoptosis-induced-by-cdte-quantum-dots
#20
Tianshu Wu, Qingling Zhan, Ting Zhang, Shengjun Ang, Jiali Ying, Keyu He, Shihan Zhang, Yuying Xue, Meng Tang
Quantum dots (QDs) could be used in the field of biology and medicine as excellent nano-scale fluorescent probes due to their unique optical properties, but the adverse effects of QDs are always the obstruction for its usage in living organisms. In this study, we observed that CdTe QDs exposure decreased the cell viability while increased the apoptosis rates in the L929 cells. Apart from QD-induced oxidative stress indicated by excessive ROS generation, three signal transductions, including Akt, p38 and JNK, played important roles on the regulation of cell apoptosis by CdTe QDs exposure as well...
February 20, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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