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https://www.readbyqxmd.com/read/29341952/a-pharmacological-review-leptadenia-reticulata-wight-arn-jivanti-the-real-life-giving-plant
#1
Jayesh M Dhalani, Pankaj B Nariya
The present review reveals a comprehensive description of various pharmacological studies carried out on Leptadenia reticulata, a source of several active compounds, i.e. Leptadenia reticulata plant belonging to family Asclepiadaceae, it is also known as 'Jivanti', used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy in various reported herbal formulations. The plant has been found to exhibit diverse pharmacological activities like antibacterial activity, anticancer activity, lactogenic eff ect, antioxidant activity, anti-implantation activity, anti-asthmatic activity, modulating eff ect, activity of silver nano particles, hepatoprotective activity, antifungal activity, antidiabetic activity and anti-infl ammatory activity...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29334800/research-progress-of-self-assembled-nanogel-and-hybrid-hydrogel-systems-based-on-pullulan-derivatives
#2
Tao Zhang, Ruyi Yang, Shengnan Yang, Jibin Guan, Dong Zhang, Yan Ma, Hongzhuo Liu
Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and 'switch-on/off' mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29332574/biomacromolecular-based-fibers-in-nanomedicine-a-combination-of-drug-delivery-and-tissue-engineering
#3
Elham Arkan, Abbas Hemati Azandaryani, Pouran Moradipour, Leila Behbood
BACKGROUND: Biopolymers based materials (polysaccharides, lipids, proteins, and nucleic acids) are one of the basic resources in bio-engineering sciences because of desirable features. Moreover, nanobiotechnology innovates nanomaterial and associated technique in nano medicine (drug delivery and tissue engineering). METHODS: In the nano-medicine, fibers are introduced as a successful biomimetic extracellular matrix scaffolds and drug carrier systems. Electrospinning as a simple and cost-effective technique is used to design nanofibers...
January 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29330203/personalized-rna-medicine-for-pancreatic-cancer
#4
Maud-Emmanuelle Gilles, Liangliang Hao, Ling Huang, Rajesha Rupaimoole, Pedro P Lopez-Casas, Emilia Pulver, Jong Cheol Jeong, Senthil K Muthuswamy, Manuel Hidalgo, Sangeeta N Bhatia, Frank J Slack
PURPOSE: Since drug responses vary between patients, it is crucial to develop pre-clinical or co-clinical strategies that forecast patient response. In this study, we tested whether RNA-based therapeutics were suitable for personalized medicine by using patient-derived-organoid (PDO) and patient-derived-xenograft (PDX) models.  Experimental Design: We performed microRNA (miRNA) profiling of PDX samples to determine the status of miRNA deregulation in individual pancreatic ductal adenocarcinoma (PDAC) patients...
January 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29317888/antileishmanial-activity-of-lavandula-angustifolia-and-rosmarinus-officinalis-essential-oils-and-nano-emulsions-on-leishmania-major-mrho-ir-75-er
#5
Azar Shokri, Majid Saeedi, Mahdi Fakhar, Katayoun Morteza-Semnani, Masoud Keighobadi, Saeed Hosseini Teshnizi, Hamid Reza Kelidari, Siamak Sadjadi
Background: The aim of present study was to evaluate antileishmanial effects of Lavandula angustifolia (L. angustifolia) and Rosmarinus officinalis (R. officinalis) medicinal plants essential oils and nano-emulsions on Leishmania major (L. major). Methods: The present study was performed in Leishmaniasis Reference Lab at Mazandaran University of Medical Sciences, Iran during 2016-2017. The IC50 values were calculated in both the promastigote and amastigote stages in J774 macrophage in comparison with meglumine antimoniate (MA) as positive control...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29286304/natural-nanoparticles-a-particular-matter-inspired-by-nature
#6
REVIEW
Sharoon Griffin, Muhammad Irfan Masood, Muhammad Jawad Nasim, Muhammad Sarfraz, Azubuike Peter Ebokaiwe, Karl-Herbert Schäfer, Cornelia M Keck, Claus Jacob
During the last couple of decades, the rapidly advancing field of nanotechnology has produced a wide palette of nanomaterials, most of which are considered as "synthetic" and, among the wider public, are often met with a certain suspicion. Despite the technological sophistication behind many of these materials, "nano" does not always equate with "artificial". Indeed, nature itself is an excellent nanotechnologist. It provides us with a range of fine particles, from inorganic ash, soot, sulfur and mineral particles found in the air or in wells, to sulfur and selenium nanoparticles produced by many bacteria and yeasts...
December 29, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#7
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29261332/nanomedicine-for-immunosuppressive-therapy-achievements-in-pre-clinical-and-clinical-research
#8
Hanan Al-Lawati, Hamidreza Montazeri Aliabadi, Behzad Sharif MakhmalZadeh, Afsaneh Lavasanifar
Immunosuppression has been the mainstay therapy in organ transplantation and autoimmune diseases. Different classes of drugs have been used in such disease conditions, but their effective clinical application has been limited by the emergence of systemic immunosuppression and/or individual drug side effects. Nanotechnology approaches may be used to modify the mentioned shortcomings of immunosuppressive therapy by enhancing the delivery of immunosuppressant to target cells of the immune system, thus reducing the required dose for function, and/or reducing drug distribution to non-target tissues...
December 20, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29258227/internal-nano-voids-in-yttria-stabilised-zirconia-ysz-powder
#9
Chen Barad, Gal Shekel, Michael Shandalov, Hagay Hayun, Giora Kimmel, Dror Shamir, Yaniv Gelbstein
Porous yttria-stabilised zirconia ceramics have been gaining popularity throughout the years in various fields, such as energy, environment, medicine, etc. Although yttria-stabilised zirconia is a well-studied material, voided yttria-stabilised zirconia powder particles have not been demonstrated yet, and might play an important role in future technology developments. A sol-gel synthesis accompanied by a freeze-drying process is currently being proposed as a method of obtaining sponge-like nano morphology of embedded faceted voids inside yttria-stabilised zirconia particles...
December 18, 2017: Materials
https://www.readbyqxmd.com/read/29247504/molecular-recognition-of-glyconanoparticles-by-rca-and-e-coli-k88-designing-transports-for-targeted-therapy
#10
Amed Gallegos-Tabanico, Jose A Sarabia-Sainz, H Manuel Sarabia-Sainz, Roberto Carrillo Torres, Ana M Guzman-Partida, Gabriela Ramos-Clamont Monfort, Erika Silva-Campa, Alexel J Burgara-Estrella, Aracely Angulo-Molina, Mónica Acosta-Elias, Martín Pedroza-Montero, Luz Vazquez-Moreno
The targeted drug delivery has been studied as one of the main methods in medicine to ensure successful treatments of diseases. Pharmaceutical sciences are using micro or nano carriers to obtain a controlled delivery of drugs, able to selectively interact with pathogens, cells or tissues. In this work, we modified bovine serum albumin (BSA) with lactose, obtaining a neoglycan (BSA-Lac). Subsequently, we synthesized glyconanoparticles (NPBSA-Lac) with the premise that it would be recognized by microbial galactose specific lectins...
December 16, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29215573/the-use-of-liposomes-and-nanoparticles-as-drug-delivery-systems-to-improve-cancer-treatment-in-dogs-and-cats
#11
REVIEW
Katarzyna Zabielska-Koczywąs, Roman Lechowski
BACKGROUND: Cancer remains a leading cause of death in companion animals. In human medicine, liposomes and nanoparticles have been extensively investigated as drug delivery systems (DDS) for anticancer agents due to their ability to target cancerous cells and reduce the negative side effects of free cytostatic drugs. In this review, the authors discuss the results of clinical trials using liposomes and polymer-based nanoparticles as DDS to improve cancer treatment in dogs and cats, indicating which ones seem worth further evaluation...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29211050/luminescence-based-optical-sensors-fabricated-by-means-of-the-layer-by-layer-nano-assembly-technique
#12
REVIEW
Nerea De Acha, Cesar Elosua, Ignacio Matias, Francisco Javier Arregui
Luminescence-based sensing applications range from agriculture to biology, including medicine and environmental care, which indicates the importance of this technique as a detection tool. Luminescent optical sensors are required to be highly stable, sensitive, and selective, three crucial features that can be achieved by fabricating them by means of the layer-by-layer nano-assembly technique. This method permits us to tailor the sensors' properties at the nanometer scale, avoiding luminophore aggregation and, hence, self-quenching, promoting the diffusion of the target analytes, and building a barrier against the undesired molecules...
December 6, 2017: Sensors
https://www.readbyqxmd.com/read/29208280/formulation-and-biological-actions-of-nano-bioglass-ceramic-particles-doped-with-calcarea-phosphorica-for-bone-tissue-engineering
#13
S Dinesh Kumar, K Mohamed Abudhahir, N Selvamurugan, S Vimalraj, R Murugesan, N Srinivasan, A Moorthi
The improvisation of the treatment procedures for treating the various kind of bone defects such as, bone or dental trauma and for diseases such as osteoporosis, osteomyelitis etc., need the suitable and promising biomaterials with resemblance of bone components. Bioactive glass ceramic (BGC) has recently acquired great attention as the most promising biomaterials; hence it has been widely applied as a filler material for bone tissue regeneration. Because it elicts specific biological responses after implantation in addition more potential in formation of strong interface with both hard and soft tissues by dissolution of calcium and phosphate ions...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29204909/nano-se-assimilation-and-action-in-poultry-and-other-monogastric-animals-is-gut-microbiota-an-answer
#14
Peter F Surai, Ivan I Kochish, Oksana A Velichko
Recently, a comprehensive review paper devoted to roles of nano-Se in livestock and fish nutrition has been published in the Nanoscale Research Letters. The authors described in great details an issue related to nano-Se production and its possible applications in animal industry and medicine. However, molecular mechanisms of nano-Se action were not described and the question of how nano-Se is converted into active selenoproteins is not resolved. It seems likely that the gut microbiota can convert nano-Se into selenite, H2Se or Se-phosphate with the following synthesis of selenoproteins...
December 4, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29199133/innovative-strategies-for-intervertebral-disc-regenerative-medicine-from-cell-therapies-to-multiscale-delivery-systems
#15
REVIEW
Nina Henry, Johann Clouet, Jean Le Bideau, Catherine Le Visage, Jérôme Guicheux
As our understanding of the physiopathology of intervertebral disc (IVD) degeneration has improved, novel therapeutic strategies have emerged, based on the local injection of cells, bioactive molecules, and nucleic acids. However, with regard to the harsh environment constituted by degenerated IVDs, protecting biologics from in situ degradation while allowing their long-term delivery is a major challenge. Yet, the design of the optimal approach for IVD regeneration is still under debate and only a few papers provide a critical assessment of IVD-specific carriers for local and sustained delivery of biologics...
December 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29196171/nano-silver-particle-synthesis-using-swertia-paniculata-herbal-extract-and-its-antimicrobial-activity
#16
Vivek Ahluwalia, Sasikumar Elumalai, Vinod Kumar, Sandeep Kumar, Rajender Singh Sangwan
In the present study, green synthesis of silver nanoparticles (AgNPs) was demonstrated using medicinal herb Swertia paniculata extract. The plant extract acted both as reducing and capping agents during synthesis process, where silver nitrate was used as silver source. Subsequent physico-chemical analysis revealed that particles had size range between 31 and 44 nm, and were spherical in shape. Among reaction parameters, temperature and time had significantly influenced the synthesis reaction. Also, synthesized nano particles were found stable up to 90 days...
November 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29193288/characterization-of-tumor-vascular-permeability-using-natural-dextrans-and-cest-mri
#17
Yuguo Li, Yuan Qiao, Hanwei Chen, Renyuan Bai, Verena Staedtke, Zheng Han, Jiadi Xu, Kannie W Y Chan, Nirbhay Yadav, Jeff W M Bulte, Shibin Zhou, Peter C M van Zijl, Guanshu Liu
PURPOSE: To investigate the use of natural dextrans as nano-sized chemical exchange saturation transfer (CEST) MRI probes for characterizing size-dependent tumor vascular permeability. METHODS: Dextrans of different molecular weight (10, 70, 150, and 2000 kD) were characterized for their CEST contrast. Mice (N = 5) bearing CT26 subcutaneous colon tumors were injected intravenously with 10 kD (D10, 6 nm) and 70 kD (D70, 12 nm) dextran at a dose of 375 mg/kg...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29189739/small-gold-nanorods-recent-advances-in-synthesis-biological-imaging-and-cancer-therapy
#18
REVIEW
Lu An, Yuanyuan Wang, Qiwei Tian, Shiping Yang
Over the past few decades, the synthetic development of ultra-small nanoparticles has become an important strategy in nano-medicine, where smaller-sized nanoparticles are known to be more easily excreted from the body, greatly reducing the risk caused by introducing nano-theranostic agents. Gold nanorods are one of the most important nano-theranostic agents because of their special optical and electronic properties. However, the large size (diameter > 6 nm) of most obtained gold nanorods limits their clinical application...
November 30, 2017: Materials
https://www.readbyqxmd.com/read/29185339/ultra-bright-fluorescent-silica-nanoparticle-embedded-with-conjugated-oligomers-and-their-application-for-latent-fingerprint-detection
#19
Shijie Zhang, Ronghua Liu, Qianling Cui, Yu Yang, Qian Cao, Wenqiang Xu, Lidong Li
Fluorescent micro- and nano-sized particles have a broad range of applications in biology, medicine, and engineering. For these uses the materials should have high emission efficiency and good photostability. However, many organic fluorophores suffer from aggregation-induced quenching effects and photobleaching. Here, we used a simple method based on covalently blending a fluorescent conjugated oligomer with silica nanoparticles to achieve emission quantum yields as high as 97%. The resulting system also showed excellent stability under continuous light illumination, a range of pH values and temperatures, and in common solvents...
November 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29179738/laser-modified-titanium-surfaces-enhance-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells
#20
Tatiana A B Bressel, Jana Dara Freires de Queiroz, Susana Margarida Gomes Moreira, Jéssyca T da Fonseca, Edson A Filho, Antônio Carlos Guastaldi, Silvia Regina Batistuzzo de Medeiros
BACKGROUND: Titanium surfaces have been modified by various approaches with the aim of improving the stimulation of osseointegration. Laser beam (Yb-YAG) treatment is a controllable and flexible approach to modifying surfaces. It creates a complex surface topography with micro and nano-scaled patterns, and an oxide layer that can improve the osseointegration of implants, increasing their usefulness as bone implant materials. METHODS: Laser beam irradiation at various fluences (132, 210, or 235 J/cm2) was used to treat commercially pure titanium discs to create complex surface topographies...
November 28, 2017: Stem Cell Research & Therapy
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