keyword
MENU ▼
Read by QxMD icon Read
search

Nano medicine

keyword
https://www.readbyqxmd.com/read/28427246/nanotechnology-and-diabetic-wound-healing-a-review
#1
Dinesh Kumar Chellappan, Yap Yenese, Chew Chian Wei, Gaurav Gupta
The incidence of diabetes has been on the rise and the rate of rise since the turn of this century has been phenomenal. One of the various battling issues faced by diabetics all over the globe is the management of diabetic wounds. Currently there are several management strategies to deal with the treatment of diabetic wounds. The conventional methods have several limitations. One of the major limitations is the rate and progression of healing of a diabetic wound when adopting a conventional diabetic wound management therapy...
April 21, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28416142/nanoparticle-mediated-drug-delivery-system-for-atherosclerotic-cardiovascular-disease
#2
REVIEW
Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Kensuke Egashira, Hiroyuki Tsutsui
Administration of drugs and other therapeutic agents has been the central strategy of contemporary medicine for cardiovascular disease. The use of drug delivery systems (DDS) includes micelles, liposomes, polymeric nanoparticles, dendrimers, carbon nanotubes, and crystalline metals. Nano-DDS modify in vivo drug kinetics, depending on (patho)physiological mechanisms such as retard excretion, vascular permeability, and incorporation by mononuclear phagocyte systems, which constitute the 'passive-targeting' property of nano-DDS...
April 13, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28415461/a-new-bioavailability-enhancement-strategy-of-curcumin-via-self-assembly-nano-complexation-of-curcumin-and-bovine-serum-albumin
#3
Hong Yu, Minh-Hiep Nguyen, Wean Sin Cheow, Kunn Hadinoto
Amorphous drug nanoparticles have recently emerged as a superior bioavailability enhancement strategy for poorly soluble drugs in comparison to the conventional microscale amorphous solid dispersions. In particular, amorphous drug nanoparticle complex (or nanoplex) represents an attractive bioavailability enhancement strategy of curcumin (CUR) - a medicinal herb known for its wide-ranging therapeutic activities - attributed to the high payload, cost-effective preparation, and supersaturation generation of the nanoplex...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28403790/molecular-design-and-medicinal-applications-of-nano-nitric-oxide-delivery-systems
#4
Kim Truc Nguyen, Zhouran Wu, Tiantian Huang, Chor Yong Tay
Nitric oxide (NO) regulates numerous biological processes that are important in the maintenance of homeostatic balance in the human body. Due to its innate biological significance, much effort has been vested to exploit NO as a pharmaceutical agent in recent years. The key to fully harness NO's therapeutic potential will require the innovative integration of the NO releasing molecules (NORMs) with cytocompatible nano-scale carriers so that controlled spatiotemporal delivery of NO to targeted diseases sites can be attained...
April 7, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28365418/higher-functionality-of-extracellular-vesicles-isolated-using-size-exclusion-chromatography-compared-to-ultracentrifugation
#5
Emma A Mol, Marie-José Goumans, Pieter A Doevendans, Joost P G Sluijter, Pieter Vader
Extracellular vesicles (EVs) are nano-sized, lipid bilayer-enclosed particles involved in intercellular communication. EVs are increasingly being considered as drug delivery vehicles or as cell-free approach to regenerative medicine. However, one of the major challenges for their clinical application is finding a scalable EV isolation method that yields functional EVs. Although the golden standard for EV isolation is ultracentrifugation (UC), a recent study suggested that isolation using size-exclusion chromatography (SEC) yielded EVs with more intact biophysical properties...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28359959/designing-new-surfactant-peptides-for-binding-to-carbon-nanotubes-via-computational-approaches
#6
Alireza Mansouri, Karim Mahnam
The non-covalent interaction between single-walled carbon nanotube and surfactant peptides makes them soluble in biological media to be used in nano-medicine, drug delivery and gene therapy. Pervious study has shown that two important parameters in binding peptides into nanotubes are hydrophobic effect and the number of aromatic amino acids. Ten surfactant peptides with the length of eight residue, including Lys, Trp, Tyr, Phe and Val, were designed to investigate the important parameters in binding peptides to a (6, 6) carbon nanotube...
March 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28343075/an-update-on-application-of-nanotechnology-and-stem-cells-in-spinal-cord-injury-regeneration
#7
REVIEW
Kazem Nejati-Koshki, Yousef Mortazavi, Younes Pilehvar-Soltanahmadi, Sumit Sheoran, Nosratollah Zarghami
Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. The pathophysiological advancement of SCI is divided into two categories: primary injury and secondary injury. Due to the loss of motor, sensory, or cognitive function, a patient's quality of life is likely reduced and places a great burden on society in order to supply health care costs. Therefore, it is important to develop suitable therapeutic strategies for SCI therapy...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28335352/nano-biosensor-for-monitoring-the-neural-differentiation-of-stem-cells
#8
REVIEW
Jin-Ho Lee, Taek Lee, Jeong-Woo Choi
In tissue engineering and regenerative medicine, monitoring the status of stem cell differentiation is crucial to verify therapeutic efficacy and optimize treatment procedures. However, traditional methods, such as cell staining and sorting, are labor-intensive and may damage the cells. Therefore, the development of noninvasive methods to monitor the differentiation status in situ is highly desirable and can be of great benefit to stem cell-based therapies. Toward this end, nanotechnology has been applied to develop highly-sensitive biosensors to noninvasively monitor the neural differentiation of stem cells...
November 28, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#9
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335186/ex-vivo-tissues-engineering-modeling-for-reconstructive-surgery-using-human-adult-adipose-stem-cells-and-polymeric-nanostructured-matrix
#10
Francesco Morena, Chiara Argentati, Eleonora Calzoni, Marino Cordellini, Carla Emiliani, Francesco D'Angelo, Sabata Martino
The major challenge for stem cell translation regenerative medicine is the regeneration of damaged tissues by creating biological substitutes capable of recapitulating the missing function in the recipient host. Therefore, the current paradigm of tissue engineering strategies is the combination of a selected stem cell type, based on their capability to differentiate toward committed cell lineages, and a biomaterial, that, due to own characteristics (e.g., chemical, electric, mechanical property, nano-topography, and nanostructured molecular components), could serve as active scaffold to generate a bio-hybrid tissue/organ...
March 31, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334693/fabrication-of-human-hair-keratin-jellyfish-collagen-eggshell-derived-hydroxyapatite-osteoinductive-biocomposite-scaffolds-for-bone-tissue-engineering-from-waste-to-regenerative-medicine-products
#11
Yavuz Emre Arslan, Tugba Sezgin Arslan, Burak Derkus, Emel Emregul, Kaan C Emregul
In the present study, we aimed at fabricating an osteoinductive biocomposite scaffold using keratin obtained from human hair, jellyfish collagen and eggshell-derived nano-sized spherical hydroxyapatite (nHA) for bone tissue engineering applications. Keratin, collagen and nHA were characterized with the modified Lowry method, free-sulfhydryl groups and hydroxyproline content analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and thermal gravimetric analysis (TGA) which confirmed the success of the extraction and/or isolation processes...
March 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28315912/an-imaging-target-tgf-%C3%AE-1-for-hepatocellular-carcinoma-in-mice
#12
Yiqiu Zhang, Beilei Li, Xiao Li, Hui Tan, Dengfeng Cheng, Hongcheng Shi
It has been reported that the positive detection rate of Fluorine-18-fluorodeoxyglucose ((18)F-FDG) metabolism in positron emission tomography (PET) imaging, for the diagnosis of hepatocellular carcinoma (HCC) is only about 50%. In particular, (18)F-FDG PET imaging is prone to false negative findings in HCC. Transforming growth factor-beta1 (TGF-β1) shows over expression rates in early HCC liver tissue growth and promotes tumor invasion and metastases. Our aim was to use In this study, we used the feasibility of iodine-125 ((125)I)-labeled TGF-β1 antibody as a nuclear medicine imaging target in HCC...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28302035/translational-multimodality-neuroimaging
#13
Sushil K Sharma
Recently high-resolution, noninvasive, multimodality in-vivo molecular imaging with PET, SPECT, CT and MRI, employing fusion algorithms has revolutionized personalized medicine. However, specific radiopharmaceuticals (RPs) for the accurate diagnosis and effective treatment of progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, drug addiction, and other cognitive impairments still remain in developmental phase. Currently, multimodality fusion neuroimaging is utilized for the determination of: pharmacokinetics and pre-clinical development of radiopharmaceuticals (RPs); in-vivo monitoring of stem cell transplantation therapy; nicotinic acetylcholine receptors (nAChRs) investigations; and regional cerebral blood flow and glucose metabolism in cognitively-impaired subjects employing noninvasive microPET and nano-SPECT imaging...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28300393/remote-control-and-modulation-of-cellular-events-by-plasmonic-gold-nanoparticles-implications-and-opportunities-for-biomedical-applications
#14
Jiayang Li, Jing Liu, Chunying Chen
Compared to traditional hyperthermia methods, gold nanoparticles (Au NPs) successfully achieve site-specific incremental temperature in deep tissues. By virtue of near-infrared (NIR) laser-mediated photothermal treatment, Au NPs have been widely explored in clinical and preclinical applications, including cancer therapy and tissue engineering. In this issue of ACS Nano, Suzuki, Ciofani, and colleagues demonstrate how gold nanoshells can remotely activate striated muscle cells via inducing myotube contraction and modulating related gene expression by mild heat stimulation under NIR irradiation...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28288456/from-technique-of-tattooing-to-biokinetics-and-toxicology-of-injected-tattoo-ink-particles-and-chemicals
#15
Jørgen Serup
Tattoo colourants are colourful nano- and microparticles, which are practically insoluble and thus permanent once installed in the dermis by the tattooist. Tattoo ink also has soluble ingredients and contaminants. Pigments can distribute via the lymph and possibly also directly to the blood, and a minute fraction may over time undergo metabolic breakdown and as hapten(s) induce allergic reactions of red tattoos. Carbon black of black tattoos has a tendency to agglomerate and form larger bodies that can elicit foreign body reactions in black tattoos and even granuloma formation with overlap to sarcoidosis in the clinic...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28275628/extracellular-vesicles-small-bricks-for-tissue-repair-regeneration
#16
COMMENT
Simona Taverna, Marzia Pucci, Riccardo Alessandro
Extracellular vesicles (EVs) are nano-sized membrane vesicles involved in intercellular communication. EVs have pleiotropic actions in physiological and pathological conditions. The ability of EVs to transports proteins, drugs and nucleic acid, to target specific cells and to increase the stability of therapeutic cargo, make EVs interesting as new devices for the treatment of human disease. In a recently published issue of European journal of pharmaceutical sciences, Silva and colleagues reviewed the ability of EVs to modulate tissue repair and regeneration, focusing on their roles and therapeutic potential as immunomodulatory messengers...
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28271478/symmetry-directed-design-of-protein-cages-and-protein-lattices-and-their-applications
#17
Aaron Sciore, E Neil G Marsh
The assembly of individual protein subunits into large-scale structures is important in many biological contexts. Proteins may assemble into geometrical cages or extended lattices that are characterized by a high degree of symmetry; examples include viral capsids and bacterial S-layers. The precisely defined higher order structure exhibited by these assemblies has inspired efforts to design such structures de novo by applying the principles of symmetry evident in natural protein assemblies. Here we discuss progress towards this goal and also examples of natural protein cages and lattices that have been engineered to repurpose them towards a diverse range of applications in materials science and nano-medicine...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28268943/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#18
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267316/advances-toward-more-efficient-targeted-delivery-of-nanoparticles-in-vivo-understanding-interactions-between-nanoparticles-and-cells
#19
Ester Polo, Manuel Collado, Beatriz Pelaz, Pablo Del Pino
In this Perspective, we describe current challenges and recent advances in efficient delivery and targeting of nanoparticles in vivo. We discuss cancer therapy, nanoparticle-biomolecule interactions, nanoparticle trafficking in cells, and triggers and responses to nanoparticle-cell interactions. No matter which functionalization strategy to target cancer is chosen, passive or active targeting, more than 99% of the nanoparticles administered in vivo end up in the mononuclear phagocytic system, mainly sequestered by macrophages...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28261169/the-disruption-of-an-oxyr-like-protein-impairs-intracellular-magnetite-biomineralization-in-magnetospirillum-gryphiswaldense-msr-1
#20
Yunpeng Zhang, Tong Wen, Fangfang Guo, Yuanyuan Geng, Junquan Liu, Tao Peng, Guohua Guan, Jiesheng Tian, Ying Li, Jilun Li, Jing Ju, Wei Jiang
Magnetotactic bacteria synthesize intracellular membrane-enveloped magnetite bodies known as magnetosomes which have been applied in biotechnology and medicine. A series of proteins involved in ferric ion transport and redox required for magnetite formation have been identified but the knowledge of magnetosome biomineralization remains very limited. Here, we identify a novel OxyR homolog (named OxyR-Like), the disruption of which resulted in low ferromagnetism and disfigured nano-sized iron oxide crystals. High resolution-transmission electron microscopy showed that these nanoparticles are mainly composed of magnetite accompanied with ferric oxide including α-Fe2O3 and ...
2017: Frontiers in Microbiology
keyword
keyword
27086
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"