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https://www.readbyqxmd.com/read/28097599/biosynthesis-characterization-and-bioactivities-evaluation-of-silver-and-gold-nanoparticles-mediated-by-the-roots-of-chinese-herbal-angelica-pubescens-maxim
#1
Josua Markus, Dandan Wang, Yeon-Ju Kim, Sungeun Ahn, Ramya Mathiyalagan, Chao Wang, Deok Chun Yang
A facile synthesis and biological applications of silver (DH-AgNps) and gold nanoparticles (DH-AuNps) mediated by the aqueous extract of Angelicae Pubescentis Radix (Du Huo) are explored. Du Huo is a medicinal root belonging to Angelica pubescens Maxim which possesses anti-inflammatory, analgesic, and antioxidant properties. The absorption spectra of nanoparticles in varying root extract and metal ion concentration, pH, reaction temperatures, and time were recorded by ultraviolet-visible (UV-Vis) spectroscopy...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28095860/mouse-models-of-atherosclerosis-a-historical-perspective-and-recent-advances
#2
REVIEW
Yee Ting Lee, Hiu Yu Lin, Yin Wah Fiona Chan, Ka Hou Christien Li, Olivia Tsz Ling To, Bryan P Yan, Tong Liu, Guangping Li, Wing Tak Wong, Wendy Keung, Gary Tse
Atherosclerosis represents a significant cause of morbidity and mortality in both the developed and developing countries. Animal models of atherosclerosis have served as valuable tools for providing insights on its aetiology, pathophysiology and complications. They can be used for invasive interrogation of physiological function and provide a platform for testing the efficacy and safety of different pharmacological therapies. Compared to studies using human subjects, animal models have the advantages of being easier to manage, with controllable diet and environmental risk factors...
January 17, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28087422/nano-qsar-in-cell-biology-model-of-cell-viability-as-a-mathematical-function-of-available-eclectic-data
#3
Alla P Toropova, Andrey A Toropov
The prediction of biochemical endpoints is an important task of the modern medicinal chemistry, cell biology, and nanotechnology. Simplified molecular input-line entry system (SMILES) is a tool for representation of the molecular structure. In particular, SMILES can be used to build up the quantitative structure - property / activity relationships (QSPRs/QSARs). The QSPR/QSAR is a tool to predict an endpoint for a new substance, which has not been examined in experiment. Quasi-SMILES are representation of eclectic data related to an endpoint...
January 10, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28078770/synthetic-plant-virology-for-nanobiotechnology-and-nanomedicine
#4
REVIEW
John F C Steele, Hadrien Peyret, Keith Saunders, Roger Castells-Graells, Johanna Marsian, Yulia Meshcheriakova, George P Lomonossoff
Nanotechnology is a rapidly expanding field seeking to utilize nano-scale structures for a wide range of applications. Biologically derived nanostructures, such as viruses and virus-like particles (VLPs), provide excellent platforms for functionalization due to their physical and chemical properties. Plant viruses, and VLPs derived from them, have been used extensively in biotechnology. They have been characterized in detail over several decades and have desirable properties including high yields, robustness, and ease of purification...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28075593/formation-of-nickel-clusters-wrapped-in-carbon-cages-toward-new-endohedral-metallofullerene-synthesis
#5
Alexander S Sinitsa, Thomas W Chamberlain, Thilo Zoberbier, Irina V Lebedeva, Andrey M Popov, Andrey A Knizhnik, Robert L McSweeney, Johannes Biskupek, Ute Kaiser, Andrei N Khlobystov
Despite the high potential of endohedral metallofullerenes (EMFs) for application in biology, medicine and molecular electronics, and recent efforts in EMF synthesis, the variety of EMFs accessible by conventional synthetic methods remains limited and does not include, for example, EMFs of late transition metals. We propose a method in which EMF formation is initiated by electron irradiation in aberration-corrected high-resolution transmission electron spectroscopy (AC-HRTEM) of a metal cluster surrounded by amorphous carbon inside a carbon nanotube serving as a nanoreactor and apply this method for synthesis of nickel EMFs...
January 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28069500/solution-blow-spinning-fibres-new-immunologically-inert-substrates-for-the-analysis-of-cell-adhesion-and-motility
#6
Rafaella T Paschoalin, Bruna Traldi, Gülcan Aydin, Juliano E Oliveira, Stephan Rütten, Luiz H C Mattoso, Martin Zenke, Antonio Sechi
The control of cell behaviour through material geometry is appealing as it avoids the requirement for complex chemical surface modifications. Significant advances in new technologies have been made to the development of polymeric biomaterials with controlled geometry and physico-chemical properties. Solution blow spinning technique has the advantage of ease of use allowing the production of nano or microfibres and the direct fibre deposition on any surface in situ. Yet, in spite of these advantages, very little is known about the influence of such fibres on biological functions such as immune response and cell migration...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28068637/assembling-of-multifunctional-latex-based-hybrid-nanocarriers-from-calotropis-gigantea-for-sustained-doxorubicin-dox-releases
#7
Periyakaruppan Pradeepkumar, Dharman Govindaraj, Murugaraj Jeyaraj, Murugan A Munusamy, Mariappan Rajan
Natural rubber Latex (Lax) is a colloidal dispersion of polymer particles in liquid and shows good biodegradable, biocompatibility, and non-toxicity. Natural polymers are the most important materials used in food packaging, micro/nano-drug delivery, tissue engineering, agriculture, and coating. In the present study, natural compounds extracted from plant Lax were designed to function as drug carriers using various surfactants via emulation and solvent evaporation method. Calotropis gigantea belongs to the family Apocynaceae and has received considerable attention in modern medicine, ayurvedeic, siddha, and traditional medicine...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068081/peptide-decorated-nanofibrous-niche-augments-in-vitro-directed-osteogenic-conversion-of-human-pluripotent-stem-cells
#8
Yi Deng, Yuanyi Yang, Shicheng Wei
Realization of clinical potential of human pluripotent stem cells (hPSCs) in bone regenerative medicine requires development of simple and safe biomaterials for expansion of hPSCs followed by directing their lineage commitment to osteoblasts. In the present study, a chemically defined peptide-decorated polycaprolactone (PCL) nanofibrous microenvironment was prepared through electrospinning technology and subsequent conjugation with vitronectin peptide to promote the culture and osteogenic potential of hPSCs in vitro...
January 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28064105/a-brief-review-on-the-application-of-nanoparticle-enclosed-herbal-medicine-for-the-treatment-of-infective-endocarditis
#9
REVIEW
Mehrdad Namdari, Ali Eatemadi, Maryam Soleimaninejad, Aiyelabegan T Hammed
Herbal medicines have been routinely employed all over the world dated back from the ancient time and have been identified by patients and physicians for their excellent therapeutic value as they have lower adverse effects when compared with the modern medicines. Phytotherapeutics requires a scientific technique to deliver the active herbal extract in a controlled manner to avoid repeated administration and increase patient compliance. This can be reached by fabricating a novel drug delivery systems (NDDS) for herbal components...
January 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28062299/bio-nano-interface-the-impact-of-biological-environment-on-nanomaterials-and-their-delivery-properties
#10
REVIEW
Kaimin Cai, Andrew Z Wang, Lichen Yin, Jianjun Cheng
The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, and medicine. While a few clinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM...
January 3, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28042778/personalized-nanoparticles-for-cancer-therapy-a-call-for-greater-precision
#11
Nare Sahakyan, Amir Haddad, Shye Richardson, Valery Forcha-Etieundem, Lee Christopher, Hanan Alharbi, Robert Campbell
Nanotechnology has brought about the advent of personalized medicine in the era of targeted therapeutic strategies for cancer therapy. The ability to exploit tumor features for therapeutic gain has made it possible to manufacture more effective nanomedicines for cancer treatment. However, known obstacles, including the inability to overcome pathophysiological barriers of tumors, have impeded disease management. In spite of this, recent efforts have been made to develop more functionalized nanosystems that utilize the active-targeting approach...
January 2, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28031711/synergistic-anti-glioma-effect-of-a-coloaded-nano-drug-delivery-system
#12
Huae Xu, Feng Jia, Pankaj Kumar Singh, Shu Ruan, Hao Zhang, Xiaolin Li
The anti-glioma effect of temozolomide (Tem) is sometimes undermined by the emerging resistance. Recently, resveratrol (Res), herbal medicine extracted from grape seeds, has been demonstrated for its potential use in chemosensitization. In the current study, both these drugs were loaded simultaneously into nanoparticles with methoxy poly(ethylene glycol)-poly epsilon caprolactone (mPEG-PCL) as drug carriers in order to achieve better antitumor efficiency. Tem/Res-coloaded mPEG-PCL nanoparticles were constructed, characterized, and tested for antitumor effect on glioma cells by using in vitro and xenograft model system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28025942/nano-medicine-improving-the-bioavailability-of-small-molecules-for-the-prevention-of-neurodegenerative-diseases
#13
Piera Di Martino, Roberta Censi, Maria Rosa Gigliobianco, Luana Zerrillo, Federico Magnoni, Dimitrios Agas, Wilma Quaglia, Giulio Lupidi
Neurodegenerative diseases, including Parkinson's and Alzheimer's, are a heterogeneous group of brain disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system. It is thought that the number of people affected by these pathologies will increase in future decades, particularly in the more economically developed countries, where the populations are experiencing a demographic shift towards older ages. For many of these pathologies, and in particular for Alzheimer's disease, no effective treatments are available, and the consequent economic and social costs are very high...
December 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28004516/interaction-mechanism-and-clustering-among-rgd-peptides-and-integrins
#14
Xiuli Dong, Yuping Yu, Qi Wang, Ying Xi, Yingchun Liu
Peptides with an exposed arginine-glycine- aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin αV β3 play an important role in targeted anticancer drug delivery. The interaction of multiple RGD-containing peptides and two αV β3 molecules was studied via MD simulation. Results revealed that not all six RGD-containing peptides interact with αV β3 and interaction strengths differed among the peptides. The specific identification sites included the guanidine group of the ARG residue in the RGD peptide and the carboxyl group of the ASP residue in integrin αV β3 ...
December 22, 2016: Molecular Informatics
https://www.readbyqxmd.com/read/27988472/co-delivery-of-docetaxel-and-verapamil-by-reduction-sensitive-peg-plga-ss-dtx-conjugate-micelles-to-reverse-the-multi-drug-resistance-of-breast-cancer
#15
Yuanyuan Guo, Wenxiu He, Shengfeng Yang, Dujuan Zhao, Zhonghao Li, Yuxia Luan
The clinical usage of docetaxel (DTX) has been blocked in the clinic because of its poor solubility and tumour multi-drug resistance (MDR). The dominating mechanism of MDR is the over-expression of p-gp on tumour cells. Traditional nano-medicines, such as nanoparticles and micelles, have been used to physically entrap DTX to improve their solubility, while the drug loading content was very low and the tumour resistance was neglected. In this study, the synthesized reduction-sensitive mPEG-PLGA-SS-DTX conjugate was utilized to load the p-gp inhibitor veraparmil (VRP) to prepare DTX and VRP co-delivered mPEG-PLGA-SS-DTX/VRP (PP-SS-DTX/VRP) multi-functional micelles to reverse MDR and enhance the anti-tumour effect of DTX...
December 11, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27988019/nano-carbohydrates-synthesis-and-application-in-genetics-biotechnology-and-medicine
#16
REVIEW
Ali Jebali, Elham Khajeh Nayeri, Sima Roohana, Shiva Aghaei, Maede Ghaffari, Karim Daliri, Garcia Fuente
Combining nanoparticles with carbohydrate has triggered an exponential growth of research activities for the design of novel functional bionanomaterials, nano-carbohydrates. Recent advances in versatile synthesis of glycosylated nanoparticles have paved the way towards diverse biomedical applications. The accessibility of a wide variety of these structured nanosystems, in terms of shape, size, and organization around stable nanoparticles, has readily contributed to their development and application in nanomedicine...
November 9, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27987773/scaffolds-of-hydroxyl-apatite-nanoparticles-disseminated-in-1-6-diisocyanatohexane-extended-poly-1-4-butylene-succinate-poly-methyl-methacrylate-for-bone-tissue-engineering
#17
Kulwinder Kaur, K J Singh, Vikas Anand, Gaurav Bhatia, Raminderjit Kaur, Manpreet Kaur, Lovedeep Nim, Daljit Singh Arora
Poly(1, 4-butyl succinate) extended 1, 6-diisocyanatohexane (PBSu-DCH) polymers and Polymethylmethacrylate (PMMA) scaffolds decorated with nano hydroxyl apatite have been prepared and characterized for regeneration of bone in cranio-maxillofacial region. Synthesized scaffolds revealed good response in bone regeneration and excellent cell viability in comparison to commercial available glass plate, which lead to better proliferation of MG-63 cell lines. Additionally, they demonstrate high porosity and excellent water retention ability...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27984778/oral-administration-of-nano-titanium-dioxide-particle-disrupts-hepatic-metabolic-functions-in-a-mouse-model
#18
Julin Yang, Min Luo, Zhen Tan, Manyun Dai, Minzhu Xie, Jiao Lin, Huiying Hua, Qing Ma, Jinshun Zhao, Aiming Liu
TiO2 nano-particle (TiO2 NP) is widely used in industrial, household necessities, as well as medicinal products. However, the effect of TiO2 NP on liver metabolic function has not been reported. In this study, after mice were orally administered TiO2 NP (21nm) for 14days, the serum and liver tissues were assayed by biochemical analysis, real time quantitative polymerase chain reaction, western blot and transmission electron microscopy. The serum bilirubin was increased in a dose dependent manner. Deposition of TiO2 NP in hepatocytes and the abnormality of microstructures was observed...
December 11, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27956360/defining-the-hierarchical-organisation-of-collagen-vi-microfibrils-at-nanometre-to-micrometre-length-scales
#19
Alan R F Godwin, Tobias Starborg, Michael J Sherratt, Alan M Roseman, Clair Baldock
: Extracellular matrix microfibrils are critical components of connective tissues with a wide range of mechanical and cellular signalling functions. Collagen VI is a heteromeric network-forming collagen which is expressed in tissues such as skin, lung, blood vessels and articular cartilage where it anchors cells into the matrix allowing for transduction of biochemical and mechanical signals. It is not understood how collagen VI is arranged into microfibrils or how these microfibrils are arranged into tissues...
December 10, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27943553/cell-surface-nano-modulation-for-non-invasive-in%C3%A2-vivo-near-ir-stem-cell-monitoring
#20
Woo Jung Shin, Seung Won Shin, Ji Soo Yuk, Lunjakorn Amornkitbamrung, Min Su Jang, In Hyun Song, Soon Won Choi, Insung Kang, Jin Young Lee, Hojae Bae, Kyung-Sun Kang, Soong Ho Um
A stem cell tracking system is in high demand for the determination of cell destinations and for the validation of cell therapeutic efficacy in regenerative transplantation. To date, near-infrared (NIR) imaging technology has received considerable attention in cell behavior monitoring, owing to its patient compatibility, easy accessibility and cost effectiveness. Conventionally, in vivo cell tracking has been visualized by direct in-cell staining with NIR, where it may be achieved by complicated genetic engineering...
December 10, 2016: ChemMedChem
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