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https://www.readbyqxmd.com/read/28531163/applications-of-gold-nanoparticles-in-nanomedicine-recent-advances-in-vaccines
#1
REVIEW
Sónia Alexandra Correia Carabineiro
Nowadays, gold is used in (nano-)medicine, usually in the form of nanoparticles, due to the solid proofs given of its therapeutic effects on several diseases. Gold also plays an important role in the vaccine field as an adjuvant and a carrier, reducing toxicity, enhancing immunogenic activity, and providing stability in storage. An even brighter golden future is expected for gold applications in this area.
May 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530186/synthesis-and-characterisation-of-neem-leaf-extract-2-3-dehydrosalanol-and-quercetin-dihydrate-mediated-silver-nano-particles-for-therapeutic-applications
#2
Bodaballa Avinash, Ravipati Venu, Tollamadugu N V K V Prasad, Mekapogu Alpha Raj, Kothapalli Srinivasa Rao, Chintamaneni Srilatha
The utility of green silver nanoparticles (AgNPs) in veterinary medicine is steadily increasing as they have many therapeutic applications against pathogens and arthropods of livestock. In this study, green AgNPs using neem (N-AgNPs), 2,3-dehydrosalanol (2,3-DHS-AgNPs) and quercetin dihydrate (QDH-AgNPs) were synthesised and characterised. Synthesised compounds were characterised by UV-Vis spectroscopy and the peak absorbance was recorded at 370 nm for neem extract. For N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs, the maximum absorbance peaks were at 430, 230 and 220 nm, respectively...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28528952/an-overview-of-natural-renewable-bio-polymer-lignin-towards-nano-and-biotechnological-applications
#3
REVIEW
Selvaraj Mohana Roopan
Lignin were said to be major bio-polymer next to cellulose which is an abundant biopolymer. This type of lignin was mostly isolated from woods which were named after their physical, morphological appearances and majorly on extracting sources. Still now there are very few reports on isolation, identification of pure lignin and isolating pathways are also not well defined. Molecular weight of lignin varies from thousands to ten thousands which are not explored accurately. Even-though lignins were surrounded by these many hurdles it has various application studies which were studied and reported...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28516056/simultaneous-micronization-and-purification-of-bioactive-fraction-by-supercritical-antisolvent-technology
#4
Stevanus Hiendrawan, Bambang Veriansyah, Edward Widjojokusumo, Raymond R Tjandrawinata
Simultaneous micronization and purification of DLBS3233 bioactive fraction, a combination of two Indonesian herbals Lagerstroemia speciosa and Cinnamomum burmannii has been successfully performed via supercritical anti-solvent (SAS) technology. The objective of the present study was to investigate the effectiveness of SAS technology to micronize and reduce coumarin content of DLBS3233. The effects of four SAS process parameters, i.e. pressure, temperature, concentration and solution flow rate on particle formation were investigated...
April 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28503951/gold-nanoparticles-applications-from-artificial-enzyme-till-drug-delivery
#5
Kazem Golchin, Jafar Golchin, Shahrooz Ghaderi, Neda Alidadiani, Sajjad Eslamkhah, Masoud Eslamkhah, Soodabeh Davaran, Abolfazl Akbarzadeh
Today, nano-medicine promotes new therapeutics and diagnostics tools, including sensing of biomolecules as a biosensor, cancer chemotherapy and drug or gene delivery. Because of small size and biocompatibility of gold nanoparticles (GNPs), they become a good candidate for biological application. Also, thanks to their biological and chemical properties, they can mimic function of some enzymes including super oxide dismutase (SOD), esterase, etc. Also, biomaterials and bioengineering have grown so fast since the last decade for many therapeutic applications such as tissue regeneration...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28495476/studies-on-diagnostic-biomarkers-and-therapeutic-mechanism-of-alzheimer-s-disease-through-metabolomics-and-hippocampal-proteomics
#6
Weiwei Lin, Jianmei Zhang, Yanmeng Liu, Ruijun Wu, Haisong Yang, Xiaobo Hu, Xiaomei Ling
Alzheimer's disease (AD) is the main cause of dementia, but precise diagnosis and treatment are not sufficient so far. The purpose of this study is to develop biomarkers and therapeutic targets for diagnosis and better understanding of AD. As a result, lysophosphatidylcholine and intermediates of sphingolipid metabolism including sphinganine-1-phosphate, sphingosine-1-phosphate, sphingomyelin, and sphingosine in plasma were annotated as potential biomarkers by using UPLC-Q-TOF-MS and UHPLC-Q-Exactive-MS. Besides, glutathione S-transferases (GSTs) including GstA3, Gstm1, Gstm5, Gstm3, Gstk1 and Gstp1 were significantly enhanced in AD hippocampus by using label free nano-LC-MS/MS...
May 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28494303/hemocompatibility-of-inhaled-environmental-nanoparticles-potential-use-of-in-vitro-testing
#7
REVIEW
Eleonore Fröhlich
Hemocompatibility testing is an important part in the evaluation of nano-based medicines. However, it is not systematically used for the assessment of environmental particles since they do not come in contact with blood immediately. Studies on human exposure to air-borne particles and pulmonary exposure of rodents have reported alterations in blood physiology. It is not clear, whether these effects are majorly caused by tissue inflammation or translocated particles in blood. This review addresses the question, if in vitro hemocompatibility testing could help in the risk evaluation of inhaled particles...
April 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28483694/controlling-nucleation-and-growth-of-nano-caco3-via-co2-sequestration-by-a-calcium-alkoxide-solution-to-produce-nanocomposites-for-drug-delivery-applications
#8
N G Martin Palmqvist, Jean-Marie Nedelec, Gulaim A Seisenbaeva, Vadim G Kessler
Calcium carbonate is an extremely attractive material in a plethora of biomedical applications. Intensive efforts have recently been made to achieve the control over its nucleation and subsequent aggregation, growth and crystallization; focusing on bringing insight into the role of precursors, solvents and templates. Having analyzed the recently acquired knowledge, we addressed this challenge using CO2 sequestration synthesis, using an unusual reactant, a solution of calcium ethoxide, Ca(OC2H5)2, as precursor...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28472916/the-chemo-biological-outreach-of-nano-biomaterials-implications-for-tissue-engineering-and-regenerative-medicine
#9
Pradeep Kumar, Yahya E Choonara, Riaz A Khan, Viness Pillay
Nanobiomaterials can be defined as materials interacting with and influencing the biological microenvironment at a nanointerface. Recently the basic as well as applied research related to nanobiomaterials - a conjugation of nano-, material- and life-sciences - has immensely evolved for therapeutics and related biotechnology areas. The current overview focused on the potential of nanobiomaterial-based substrates towards the generation of biocompatible surfaces, tissue engineering architectures, and regenerative medicine...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28464454/electrospun-nanofibrous-silk-fibroin-membranes-containing-gelatin-nanospheres-for-controlled-delivery-of-biomolecules
#10
Jiankang Song, Alexey Klymov, Jinlong Shao, Yang Zhang, Wei Ji, Eva Kolwijck, John A Jansen, Sander C G Leeuwenburgh, Fang Yang
Development of novel and effective drug delivery systems for controlled release of bioactive molecules is of critical importance in the field of regenerative medicine. Here, oppositely charged gelatin nanospheres are incorporated into silk fibroin nanofibers through a colloidal electrospinning technique. A novel fibrous nano-in-nano drug delivery system is fabricated without the use of any organic solvent. The distribution of fluorescently labeled gelatin A and B nanospheres inside the nanofibers can be fine-tuned by simple adjustment of the weight ratio between the nanospheres and the relative feeding rate of core and shell solutions containing nanospheres by using single and coaxial nozzle electrospinning, respectively...
May 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28453223/molecularly-imprinted-polymers-for-the-selective-extraction-of-tiliroside-from-the-flowers-of-edgeworthia-gardneri-wall-meisn
#11
Die Gao, Qi-Feng Fu, Lu-Jun Wang, Dan-Dan Wang, Kai-Lian Zhang, Feng-Qing Yang, Zhi-Ning Xia
Nano-sized molecularly imprinted polymers for tiliroside were successfully prepared by a precipitation polymerization method. Acrylamide, ethylene glycol dimethacrylate, azobisisobutyronitrile and acetonitrile/dimethyl sulfoxide mixture were used as functional monomer, cross-linker, initiator and porogen, respectively. The structural feature and morphological characterization of tiliroside-imprinted polymers were performed by Fourier transform infrared spectroscopy and scanning electron microscopy, respectively...
April 28, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28440967/toxicity-of-cisplatin-loaded-poly-butyl-cyanoacrylate-nanoparticles-in-a-brain-cancer-cell-line-anionic-polymerization-results
#12
Nejad Mohamadi, S Maryam Kazemi, Mahshid Mohammadian, Attabak Toofani Milani, Younes Moradi, Maryam Yasemi, Meysam Ebrahimi far, Maral Mazloumi Tabrizi, Hasan Ebrahimi Shahmabadi, Azim Akbarzadeh Khiyavi
Cancer is one of the most important issues in modern medicine and the most common cause of death after cardiovascular diseases in many countries. Brain cancer is one of the most common causes of cancer death among men and women, ranking third. Chemotherapeutic drugs that aim to prevent uncontrolled proliferation of cells in tissues of the body and induce apoptosis of tumor cells are prominent candidates for development. Since cisplatin has an apoptosisinducing role, it is widely used as an anticancer agent...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28435109/visible-light-inactivation-of-e-%C3%A2-coli-cytotoxicity-and-ros-determination-of-biochemically-capped-gold-nanoparticles
#13
Faheem Ullah Khan, Yongmei Chen, Naeem Ullah Khan, Aftab Ahmad, Kamran Tahir, Zia UlHaq Khan, Arif Ullah Khan, Shifa Ullah Khan, Muslim Raza, Pingyu Wan
The formation of metal nanoparticles is one of the most vast and intensifying research areas in favor of prospective applications for the advancement of new technologies. It is a well-founded, significant feature of green chemistry that making marvelous interconnection between nano-biotechnology and microbial biotechnology. In the present research, the aqueous extract of medicinally important plant Coptis Chinensis (in Chinese called "gold thread") was applied for the synthesis of gold nanoparticles (Au-NPs)...
April 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28427246/nanotechnology-and-diabetic-wound-healing-a-review
#14
Dinesh Kumar Chellappan, Yap Yenese, Chew Chian Wei, Gaurav Gupta
The incidence of diabetes has been on the rise and the rate of rise since the turn of this century has been phenomenal. One of the various battling issues faced by diabetics all over the globe is the management of diabetic wounds. Currently there are several management strategies to deal with the treatment of diabetic wounds. The conventional methods have several limitations. One of the major limitations is the rate and progression of healing of a diabetic wound when adopting a conventional diabetic wound management therapy...
April 21, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28416142/nanoparticle-mediated-drug-delivery-system-for-atherosclerotic-cardiovascular-disease
#15
REVIEW
Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Kensuke Egashira, Hiroyuki Tsutsui
Administration of drugs and other therapeutic agents has been the central strategy of contemporary medicine for cardiovascular disease. The use of drug delivery systems (DDS) includes micelles, liposomes, polymeric nanoparticles, dendrimers, carbon nanotubes, and crystalline metals. Nano-DDS modify in vivo drug kinetics, depending on (patho)physiological mechanisms such as retard excretion, vascular permeability, and incorporation by mononuclear phagocyte systems, which constitute the 'passive-targeting' property of nano-DDS...
April 13, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28415461/a-new-bioavailability-enhancement-strategy-of-curcumin-via-self-assembly-nano-complexation-of-curcumin-and-bovine-serum-albumin
#16
Hong Yu, Minh-Hiep Nguyen, Wean Sin Cheow, Kunn Hadinoto
Amorphous drug nanoparticles have recently emerged as a superior bioavailability enhancement strategy for poorly soluble drugs in comparison to the conventional microscale amorphous solid dispersions. In particular, amorphous drug nanoparticle complex (or nanoplex) represents an attractive bioavailability enhancement strategy of curcumin (CUR) - a medicinal herb known for its wide-ranging therapeutic activities - attributed to the high payload, cost-effective preparation, and supersaturation generation of the nanoplex...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28403790/molecular-design-and-medicinal-applications-of-nano-nitric-oxide-delivery-systems
#17
Kim Truc Nguyen, Zhouran Wu, Tiantian Huang, Chor Yong Tay
Nitric oxide (NO) regulates numerous biological processes that are important in the maintenance of homeostatic balance in the human body. Due to its innate biological significance, much effort has been vested to exploit NO as a pharmaceutical agent in recent years. The key to fully harness NO's therapeutic potential will require the innovative integration of the NO releasing molecules (NORMs) with cytocompatible nano-scale carriers so that controlled spatiotemporal delivery of NO to targeted diseases sites can be attained...
April 7, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28365418/higher-functionality-of-extracellular-vesicles-isolated-using-size-exclusion-chromatography-compared-to-ultracentrifugation
#18
Emma A Mol, Marie-José Goumans, Pieter A Doevendans, Joost P G Sluijter, Pieter Vader
Extracellular vesicles (EVs) are nano-sized, lipid bilayer-enclosed particles involved in intercellular communication. EVs are increasingly being considered as drug delivery vehicles or as cell-free approach to regenerative medicine. However, one of the major challenges for their clinical application is finding a scalable EV isolation method that yields functional EVs. Although the golden standard for EV isolation is ultracentrifugation (UC), a recent study suggested that isolation using size-exclusion chromatography (SEC) yielded EVs with more intact biophysical properties...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28359959/designing-new-surfactant-peptides-for-binding-to-carbon-nanotubes-via-computational-approaches
#19
Alireza Mansouri, Karim Mahnam
The non-covalent interaction between single-walled carbon nanotube and surfactant peptides makes them soluble in biological media to be used in nano-medicine, drug delivery and gene therapy. Pervious study has shown that two important parameters in binding peptides into nanotubes are hydrophobic effect and the number of aromatic amino acids. Ten surfactant peptides with the length of eight residue, including Lys, Trp, Tyr, Phe and Val, were designed to investigate the important parameters in binding peptides to a (6, 6) carbon nanotube...
March 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28343075/an-update-on-application-of-nanotechnology-and-stem-cells-in-spinal-cord-injury-regeneration
#20
REVIEW
Kazem Nejati-Koshki, Yousef Mortazavi, Younes Pilehvar-Soltanahmadi, Sumit Sheoran, Nosratollah Zarghami
Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. The pathophysiological advancement of SCI is divided into two categories: primary injury and secondary injury. Due to the loss of motor, sensory, or cognitive function, a patient's quality of life is likely reduced and places a great burden on society in order to supply health care costs. Therefore, it is important to develop suitable therapeutic strategies for SCI therapy...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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