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https://www.readbyqxmd.com/read/29455492/-relationship-between-inflammatory-cytokines-of-il-1%C3%AE-and-tnf-%C3%AE-and-intervertebral-disc-degeneration
#1
REVIEW
He Zhao, Xing Yu, Xian-Sheng Tang, Feng He, Yong-Dong Yang, Yang Xiong, Zhen-Guo Hu, Lin Xu
The inflammatory cytokines of IL-1β and TNF-α participate in the process of intervertebral disc degeneration is focused by the spine surgeons. Inflammatory cytokines represented by IL-1β and TNF-α act as the key factors in the process of intervertebral disc degeneration resulting in low back pain and radicular symptoms. Annulus fibrosus and nucleus pulposus can secrete TNF-α and IL-1β under the stimulation of mechanical injury, overstressed, genetic susceptibility and infection. The mechanism of inflammatory cytokines in intervertebral disc degeneration needs further investigation...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29452979/3-piece-inflatable-penile-prosthesis-placement-following-radical-cystoprostatectomy-and-urinary-diversion-technique-and-outcomes
#2
Jeffrey Loh-Doyle, Mukul B Patil, Hari Sawkar, Kevin Wayne, Stuart D Boyd
BACKGROUND: After radical cystoprostatectomy (RC), postoperative erectile dysfunction (ED) is a common consequence with multiple contributing etiologies. The inflatable penile prosthesis (IPP) offers patients a definitive treatment option when ED is refractory to medical therapies. Because of the hostile postoperative anatomy of these patients, a careful surgical approach is necessary for successful outcomes and to avoid adjacent organ injury. To date, there is no series describing the outcomes of 3-piece IPP placement in patients with urinary diversions...
February 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29452925/utility-of-sagittal-mr-imaging-of-the-whole-spine-in-cases-of-known-or-suspected-single-level-spinal-infection-overkill-or-good-clinical-practice
#3
Mougnyan Cox, Brian Curtis, Manisha Patel, Victor Babatunde, Adam E Flanders
OBJECTIVE: Multi-sequence sagittal magnetic resonance imaging (MRI) of the entire spine is performed in patients with known single level spondylodiscitis. Our objective is to determine the frequency of multifocal infection. METHODS: After IRB approval, a retrospective five-year review of all patients with spondylodiscitis was performed. RESULTS: MRI identified 82 patients with single-level infection. All 82 had entire spine imaging performed within 72 h of admission, showing additional non-continuous sites of infection in 19 patients (23%)...
February 13, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29452285/risk-factors-for-perioperative-morbidity-in-spine-surgeries-of-different-complexities-a-multivariate-analysis-of-1009-consecutive-patients
#4
M Farshad, D E Bauer, C Wechsler, C Gerber, A Aichmair
BACKGROUND CONTEXT: There is a broad spectrum of complications during or after surgical procedures, with differing incidences reported in the published literature. Heterogeneity can be explained by the lack of an established evidence-based classification system for documentation and classification of complications in a standardized manner. PURPOSE: To identify predictive risk factors for peri- and early post-operative morbidities in spine surgeries of different complexities in a large cohort of consecutive patients...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29448993/adjacent-level-spondylodiscitis-in-a-patient-with-thoracic-spondylodiscitis-a-case-report-and-review-of-the-literature
#5
K Farah, T Graillon, H Dufour, S Fuentes
INTRODUCTION: Adjacent level spondylodiscitis (ALS) after primary surgery for thoracic spondylodiscitis is a very rare condition. CASE REPORT: We report the case of a 76-year-old man with this pathology. A first posterior minimally invasive approach combined with anterior approach to the thoracic spine was safely performed for thoracic spondylodiscitis. More than a year later, exploration of recurrent symptoms with 18 FDG PET scan helped to diagnose ALS. Further surgery was performed...
February 12, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29447854/risk-factors-associated-complications-for-postoperative-urinary-retention-after-lumbar-surgery-for-lumbar-spinal-stenosis
#6
Joshua L Golubovsky, Haariss Ilyas, Jinxiao Chen, Joseph E Tanenbaum, Thomas E Mroz, Michael P Steinmetz
BACKGROUND CONTEXT: Postoperative Urinary Retention (POUR) is a very common post-operative complication of all surgeries (5 - 70%) that may lead to complications such as urinary tract infection (UTI), bladder over-distention, autonomic dysregulation, and increased postoperative length of stay (LOS). Within the field of spine surgery, the reported incidence of POUR is highly variable (5.6 - 38%). Lack of clear stratification of surgical level, spinal pathology, and inadequate sample size is a major limitation of available studies concerning POUR following spine surgery that may lead to inconsistency in the incidence of POUR and the ability to model its occurrence and consequences...
February 12, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29444303/the-utility-of-vancomycin-powder-in-reducing-surgical-site-infections-in-deep-brain-stimulation-surgery
#7
Ryan B Kochanski, Pouya Nazari, Sepehr Sani
BACKGROUND: The impact of vancomycin powder on reducing postoperative surgical site infections (SSIs) in spine surgery has been studied extensively and is considered standard of care at many institutions. More recently, vancomycin powder has been shown to reduce SSI in cranial neurosurgery; however, limited studies have been performed assessing its impact in reducing SSIs in deep brain stimulation (DBS) surgery. OBJECTIVE: To investigate the use of vancomycin powder as an adjunct to the current antibiotic prophylaxis regimen in DBS surgery in a large cohort of patients...
February 10, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29443786/improved-vacuum-sealing-drainage-for-treatment-of-surgical-site-infection-following-posterior-spinal-internal-fixation-a-case-report
#8
Hengyan Zhang, Qiyi Li
RATIONALE: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29435653/epidemiological-trends-in-spine-surgery-over-10%C3%A2-years-in-a-multicenter-database
#9
Kazuyoshi Kobayashi, Kei Ando, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
PURPOSE: There are few epidemiological studies of spinal surgery in Asia and none in Japan. The goal of this study was to review spine surgeries performed in our group between 2004 and 2015 in a cross-sectional study, with a focus on the effects of the superaging society on the characteristics and trends of spinal surgeries. METHODS: A retrospective review was performed for all 45,831 spinal surgeries conducted between 2004 and 2015 and recorded in our prospective multicenter database...
February 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29427010/feasibility-of-anterior-screw-fixation-in-children-a-tomographic-study
#10
Lívia Gaspar Fernandes, Alexandre Fogaça Cristante, Raphael Martus Marcon, Tarcísio Eloy Pessoa de Barros Filho, Olavo Biraghi Letaif
PURPOSE: Morphology measures of the odontoid process in children under 12 years old were carried out to demonstrate the viability of anterior internal fixation in this population once their active profile may not be compatible with successful conservative treatment. METHODS: During a 6-month period, 36 tomographic examinations of the cervical spine region that provided visualization of the odontoid process were selected. Group 1 included children between 6 and 9 years of age, and group 2 contained children from 9 to 12 years of age...
February 9, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29424785/bone-density-microarchitecture-and-tissue-quality-after-1-year-of-treatment-with-tenofovir-disoproxil-fumarate
#11
Robert Güerri-Fernández, Elisabet Lerma-Chippirraz, Ana Fernandez Marron, Natalia García-Giralt, Judit Villar-García, Jade Soldado, Alicia González-Mena, Ana Guelar, Adolfo Díez-Pérez, Todd T Brown, Hernando Knobel
: Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA) is used to assess bone health in HIV patients. DXA measures the amount of mineral, but not other key aspects of bone strength such as bone microarchitecture or bone quality. Trabecular Bone Score (TBS) and in vivo microindentation directly measure trabecular microarchitecture and bone tissue quality, respectively. The aim of this study is to measure bone strength properties using these techniques. RESULTS: Forty naïve HIV patients that were going to start antiretroviral (ART) a single pill treatment with Elvitegravir/cobicistat, Tenofovir (TDF), Emtricitavine (FTC) were included...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29424771/t-cell-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-osteoprotegerin-imbalance-is-associated-with-hiv-induced-bone-loss-in-patients-with-higher-cd4-t-cell-counts
#12
Kehmia Titanji, Aswani Vunnava, Antonina Foster, Anandi N Sheth, Jeffrey L Lennox, Andrea Knezevic, Neeta Shenvi, Kirk A Easley, Ighovwerha Ofotokun, M Neale Weitzmann
OBJECTIVE: Higher incidence of osteopenia and osteoporosis underlie increased rates of fragility fracture in HIV infection. B cells are a major source of osteoprotegerin (OPG), an inhibitor of the key osteoclastogenic cytokine receptor activator of nuclear factor-κB ligand (RANKL). We previously showed that higher B-cell RANKL/OPG ratio contributes to HIV-induced bone loss. T-cell OPG production in humans, however, remains undefined and the contribution of T-cell OPG and RANKL to HIV-induced bone loss has not been explored...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29422733/quad-fever-treatment-through-lowering-of-ambient-temperature
#13
Shyam Sundar Krishnan, Pulak Nigam, Omar Bachh, Madabushi Chakravarthy Vasudevan
Hyperpyrexia is a rare and at times fatal condition seen in an Intensive Care Unit setup. We encountered a case of a 65-year-old patient with road traffic accident presenting with dorsal spine fracture at D10 level. He underwent decompression and fusion for the same. He developed hyperpyrexia of sudden onset on the 10th day of admission with no source of infection and adequate broad-spectrum antibiotic coverage with adequate thrombo-embolic prevention in place. The patient showed no response to antipyretic agents and other cooling methods...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29417027/back-pain-an-unusual-manifestation-of-acute-lymphoblastic-leukemia-a-case-report-and-review-of-literature
#14
Magatha Sneha Latha, Ram Prakash Thirugnanasambandam, Padmasani Venkatraman, Julius Xavier Scott
Acute lymphoblastic leukemia (ALL) presented with bone pain and leukopenia is a well-recognized complex. Bone and joint pain are seen as presenting symptoms in 25% of patients with acute leukemia, but generalized osteopenia and vertebral complications are less common. Back pain due to vertebral changes as an early feature has been infrequently reported. We report a case of a 9-year-old female child who presented with back pain for 3 weeks. Blood counts and peripheral smear were normal. X-ray of the spine showed wedge-shaped deformity in L3-L5 vertebrae...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29411191/diagnostic-challenges-in-pyogenic-spinal-infection-an-expanded-role-for-fdg-pet-ct
#15
Gannon J Yu, Ingrid L Koslowsky, Silvia A Riccio, Angel K M Chu, Harvey R Rabin, Reinhard Kloiber
In a preliminary investigation of FDG-PET/CT for assessment of therapy response of pyogenic spine infection, it was concluded that activity confined to the margins of a destroyed or degenerated joint with bone-on-bone contact represents nonseptic inflammation, regardless of the intensity of uptake. Only activity in bone, soft tissue, or within the epidural space represents active infection. The purpose of this investigation was to assess the performance of these pattern-based interpretation criteria in a series of problem cases of proven or suspected spine infection...
February 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29411050/-pseudarthrosis-and-construct-failure-after-lumbar-pedicle-subtraction-osteotomy-influence-of-biomechanics-surgical-technique-biology-and-avoidance-strategies
#16
REVIEW
C Birkenmaier
There are numerous factors that can lead to construct failure and pseudarthrosis after corrective pedicle subtraction osteotomy (PSO) in the lumbar spine. Frequently, several factors are of relevance in these problematic cases. This article attempts to explain the surgical, biomechanical and biological aspects that should be understood in order to minimize the risk of pseudarthrosis and construct failure. It addresses technical varieties of the PSO procedure as well as the surgical technique, the choice of rod material and the design of multirod constructs...
February 6, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29408400/bariatric-surgery-prior-to-elective-posterior-lumbar-fusion-is-associated-with-reduced-medical-complications-and-infection
#17
Deeptee Jain, Sigurd Berven, John Carter, Alan L Zhang, Vedat Deviren
BACKGROUND CONTEXT: Severely obese patients with operative spinal pathology present a challenge to the spine surgeon, given the increased complication risk. PURPOSE: Determine the impact of bariatric surgery on perioperative complications of posterior lumbar fusion. STUDY DESIGN: Retrospective cohort study. PATIENT SAMPLE: Patients undergoing posterior lumbar fusion surgery in the State Inpatient Databases (SID) of New York, Florida, North Carolina, Nebraska, Utah, and California...
February 2, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29391295/is-eighty-the-new-sixty-outcomes-and-complications-after-lumbar-decompression-surgery-in-elderly-patients-over-80-years-of-age
#18
Julia Gerhardt, Stefanie Bette, Insa Janssen, Jens Gempt, Bernhard Meyer, Yu-Mi Ryang
OBJECTIVE: An increasing demographic aging of the general population results in a rising incidence of octo- and nonagenarians with spine disease. Patients over 65 years of age represent the majority of patients with degenerative lumbar spine disease in our daily clinical routine. Due to an increased rate of comorbidities indication for surgery is seen very reluctant. We therefore assessed complication rates of lumbar decompression with regard to neurological outcome, medical conditions in patients 80 years or older in a retrospective single center series...
January 29, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29387910/bone-density-and-microarchitecture-in-hepatitis-c-and-hiv-coinfected-postmenopausal-minority-women
#19
M T Yin, A RoyChoudhury, K Nishiyama, T Lang, J Shah, S Olender, D C Ferris, C Zeana, A Sharma, B Zingman, M Bucovsky, I Colon, E Shane
We found that HIV+/HCV+ women had 7-8% lower areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) at the spine, hip, and radius (p < 0.01) and 5-7% lower volumetric BMD (vBMD) by central quantitative computed tomography (cQCT) at the spine and hip (p < 0.05). These data suggest that true deficits in vBMD may contribute to bone fragility and excess fractures reported in HIV+/HCV+ women. INTRODUCTION: aBMD by DXA is lower in persons coinfected with HIV and HCV (HIV+/HCV+) than with HIV monoinfection (HIV+)...
February 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29383486/focal-disorders-of-the-spine-with-compensatory-deformities-how-to-define-them
#20
REVIEW
Andrea Redaelli, Pedro Berjano, Max Aebi
PURPOSE: In this paper, the authors propose classifying the epiphenomenon of spinal deformity in two different categories: structural deformity, when the main driver of the observed deformity is a fixed and stiff alteration of the spinal segments, and compensatory deformity, which includes cases where the observed deformity is due to focal abnormalities. This last category comprises, but is not limited to, spinal stenosis, spondylolisthesis, disc herniation, infection or tumor, hip disease or neurological disease (such as Parkinson's disease)...
January 30, 2018: European Spine Journal
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