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Spine infection

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https://www.readbyqxmd.com/read/29690987/-ankylosing-spinal-fractures-may-result-in-perforation-of-oesophagus
#1
Morten Mølgaard, Kamilla Truong, Kristian Høy
Oesophageal lesions due to spinal fractures are very rare and easily overlooked. In this case report a woman was involved in a minor car accident, and she was primarily examined at the accident and emergency department with no signs of fractures. Ten days later, she was readmitted due to high infection counts and back pain. She had an unstable fracture of Th4 and a perforation of the oesophagus due to ankylosing fractures. The case emphasises the need to pay attention to a possible development of secondary oesophageal perforation in ankylosing spines and unstable fractures, and the need for a special attention when examinating this group of patients...
April 9, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29690892/the-efficacy-and-safety-of-topical-administration-of-tranexamic-acid-in-spine-surgery-a-meta-analysis
#2
Wei Luo, Ru-Xin Sun, Han Jiang, Xin-Long Ma
BACKGROUND: We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy and safety of tranexamic acid (TXA) in spine surgery. METHODS: Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966-2017.11), PubMed (1966-2017.11), Embase (1980-2017.11), and ScienceDirect (1985-2017.11). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5...
April 24, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29690741/-antiseptic-effect-of-compound-lysostaphin-disinfectant-and-its-preventive-effect-on-infection-of-artificial-dermis-after-graft-on-full-thickness-skin-defect-wound-in-rats
#3
J Jin, H Zhou, Z C Cui, L Wang, P F Luo, S Z Ji, X Y Hu, B Ma, G Y Wang, S H Zhu, Z F Xia
Objective: To study the antiseptic effect of compound lysostaphin disinfectant and its preventive effect on infection of artificial dermis after graft on full-thickness skin defect wound in rats. Methods: (1) Each one standard strain of Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus were selected. Each 20 clinical strains of Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus were collected from those isolated from wound exudates of burn patients hospitalized in our wards from January 2014 to December 2016 according to the random number table...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29683855/a-week-48-randomized-phase-3-trial-of-darunavir-cobicistat-emtricitabine-tenofovir-alafenamide-in-treatment-na%C3%A3-ve-hiv-1-patients
#4
Joseph J Eron, Chloe Orkin, Joel Gallant, Jean-Michel Molina, Eugenia Negredo, Andrea Antinori, Anthony Mills, Jacques Reynes, Erika Van Landuyt, Erkki Lathouwers, Veerle Hufkens, John Jezorwski, Simon Vanveggel, Magda Opsomer
OBJECTIVES: To investigate efficacy and safety of a single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg vs. darunavir/cobicistat plus emtricitabine/tenofovir disoproxyl fumarate (TDF) (control) in antiretroviral-treatment-naïve, HIV-1-infected adults. DESIGN: Phase-3, randomized, active-controlled, double-blind, international, multicenter, noninferiority study (NCT02431247). METHODS: Seven hundred and twenty-five participants were randomized (1 : 1) to D/C/F/TAF (362) or control (363)...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29679728/magnetic-resonance-imaging-of-the-lumbar-spine-determining-clinical-impact-and-potential-harm-from-overuse
#5
Nathan M Wnuk, Tarik K Alkasab, Daniel I Rosenthal
BACKGROUND: Lumbar spine MRI is frequently said to be "overused" in the evaluation of low-back pain, yet data concerning the extent of overuse and on potential harmful effects are lacking. PURPOSE: To determine the proportion of examinations with a detectable impact on patient care (actionable outcomes). STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: 5,365 outpatient lumbar spine MR examinations OUTCOME MEASURES: Actionable outcomes included: 1) findings leading to an intervention making use of anatomical information such as surgery; 2) new diagnoses of cancer, infection, or fracture; or 3) following known lumbar spine pathology...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679726/late-presenting-dural-tear-incidence-risk-factors-and-associated-complications
#6
Wesley M Durand, J Mason DePasse, Eren O Kuris, JaeWon Yang, Alan H Daniels
BACKGROUND CONTEXT: Unrecognized and inadequately repaired intraoperative durotomies may lead to cerebrospinal fluid leak, pseudomeningocele, and other complications. Few studies have investigated durotomy that is unrecognized intraoperatively and requires additional postoperative management (hereafter, late-presenting dural tear [LPDT]), though estimates of LPDT range from 0.6 - 8.3 per 1,000 spinal surgeries. These single-center studies are based on relatively small sample sizes for an event of this rarity, all with <10 patients experiencing LPDT...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#7
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29675672/low-virulence-bacterial-infections-in-cervical-intervertebral-discs-a-prospective-case-series
#8
Yilei Chen, Xianjun Wang, Xuyang Zhang, Hong Ren, Bao Huang, Jian Chen, Junhui Liu, Zhi Shan, Zhihai Zhu, Fengdong Zhao
STUDY DESIGN: A prospective cross-sectional case series study. OBJECTIVE: To investigate the prevalence of low virulence disc infection and its associations with characteristics of patients or discs in the cervical spine. BACKGROUND: Low virulence bacterial infections could be a possible cause of intervertebral disc degeneration and/or back pain. Controversies are continuing over whether these bacteria, predominantly Propionibacterium acnes (P...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#9
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29668978/atazanavir-ritonavir-with-lamivudine-as-maintenance-therapy-in-virologically-suppressed-hiv-infected-patients-96-week-outcomes-of-a-randomized-trial
#10
Massimiliano Fabbiani, Roberta Gagliardini, Nicoletta Ciccarelli, Eugenia Quiros Roldan, Alessandra Latini, Gabriella d'Ettorre, Andrea Antinori, Antonella Castagna, Giancarlo Orofino, Daniela Francisci, Pierangelo Chinello, Giordano Madeddu, Pierfrancesco Grima, Stefano Rusconi, Barbara Del Pin, Francesca Lombardi, Alessandro D'Avino, Emanuele Focà, Manuela Colafigli, Roberto Cauda, Simona Di Giambenedetto, Andrea De Luca
Objectives: To investigate the long-term safety and efficacy of a treatment switch to dual ART with atazanavir/ritonavir + lamivudine versus continuing a standard regimen with atazanavir/ritonavir + 2NRTI in virologically suppressed patients. Methods: ATLAS-M is a 96 week open-label, randomized, non-inferiority (margin -12%) trial enrolling HIV-infected adults on atazanavir/ritonavir + 2NRTI, with stable HIV-RNA <50 copies/mL and CD4 counts >200 cells/mm3...
April 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29662751/blood-transfusion-and-postoperative-infection-in-spine-surgery-a-systematic-review
#11
Christian Fisahn, Cameron Schmidt, Josh E Schroeder, Emiliano Vialle, Isador H Lieberman, Joseph R Dettori, Thomas A Schildhauer
Study Design: Systematic review. Objectives: Allogeneic blood transfusion-related immunomodulation may relatively suppress the immune system, heightening the risk of infection following spine surgery. This systematic review seeks to determine whether allogeneic blood transfusion increases the risk of postoperative infection and whether there are any factors that modify this association. Methods: PubMed, Cochrane Central Register of Controlled Trials, and reference lists from included studies were searched from inception to April 20, 2017 to identify studies examining the risk of infection following allogeneic blood transfusion in adult patients receiving surgery for degenerative spine disease...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29657440/magnetic-growth-modulation-in-orthopaedic-and-spine-surgery
#12
REVIEW
Adam E M Eltorai, Carolina Fuentes
Purpose: To examine distraction-based methods for treatment of early onset scoliosis (EOS), focusing on the magnetically controlled growing rod system (MCGR) relative to traditional growing rod system (TGR). To briefly discuss internal magnetically controlled nails for bone lengthening as another application of magnetic growth modulation. Results: Relative to TGR, MCGR involves fewer complications related to infection and general anesthesia because of fewer successive surgeries required...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656619/impact-of-resident-involvement-in-neurosurgery-an-american-college-of-surgeons-national-surgical-quality-improvement-program-database-analysis-of-33-977-patients
#13
Andreea Seicean, Prateek Kumar, Sinziana Seicean, Duncan Neuhauser, Warren R Selman, Nicholas C Bambakidis
OBJECTIVE: There is conflicting and limited literature on the effect of intraoperative resident involvement on surgical outcomes. Our study assessed effects of resident involvement on outcomes in patients undergoing neurosurgery. METHODS: We identified 33,977 adult neurosurgical cases from 374 hospitals in the 2006-2012 National Surgical Quality Improvement Program, a prospectively collected national database with established reproducibility and validity. Outcomes were compared according to resident involvement before and after 1:1 matching on procedure and perioperative risk factors...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29650783/percutaneous-ct-guided-biopsies-of-the-cervical-spine-technique-histopathologic-and-microbiologic-yield-and-safety-at-a-single-academic-institution
#14
E L Wiesner, T J Hillen, J Long, J W Jennings
BACKGROUND AND PURPOSE: Cervical spine biopsies can be challenging due to the anatomy and the adjacent critical structures. Percutaneous image-guided biopsies can obviate the need for an open biopsy, however there have been few studies looking at the approaches, safety, and efficacy of percutaneous cervical spine biopsies. This retrospective study evaluated technical considerations, histopathologic and microbiologic yield, and safety in CT-guided cervical bone biopsies. MATERIALS AND METHODS: A retrospective review of cervical bone and/or bone/disc biopsies performed from January 2010 to January 2017 was included in this study...
April 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29629587/an-nihr-approved-two-year-observational-study-on-magnetically-controlled-growth-rods-in-the-treatment-of-early-onset-scoliosis
#15
C Nnadi, C Thakar, J Wilson-MacDonald, P Milner, A Rao, D Mayers, J Fairbank, T Subramanian
Aims The primary aim of this study was to evaluate the performance and safety of magnetically controlled growth rods in the treatment of early onset scoliosis. Secondary aims were to evaluate the clinical outcome, the rate of further surgery, the rate of complications, and the durability of correction. Patients and Methods We undertook an observational prospective cohort study of children with early onset scoliosis, who were recruited over a one-year period and followed up for a minimum of two years. Magnetically controlled rods were introduced in a standardized manner with distractions performed three-monthly thereafter...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29629576/spinal-infections-in-children
#16
R Dayer, M M Alzahrani, N Saran, J A Ouellet, P Journeau, A Tabard-Fougère, S Martinez-Álvarez, D Ceroni
Aims This multicentre, retrospective study aimed to improve our knowledge of primary pyogenic spinal infections in children by analyzing a large consecutive case series. Patients and Methods The medical records of children with such an infection, treated at four tertiary institutions between 2004 and 2014, were analyzed retrospectively. Epidemiological, clinical, paraclinical, radiological, and microbiological data were evaluated. There were 103 children, of whom 79 (76.7%) were aged between six months and four years...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29620948/impact-of-vancomycin-treatment-on-human-mesenchymal-stromal-cells-during-osteogenic-differentiation
#17
Jason T Bariteau, Rishin J Kadakia, Brian C Traub, Manjula Viggeswarapu, Nick J Willett
BACKGROUND: Vancomycin is frequently applied locally to the operative site during foot and ankle procedures to help prevent infection. Although the efficacy of locally applied vancomycin has been demonstrated in spine surgery, there is no consensus on dosing and indication within foot and ankle surgery. Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) is key to healing of both fractures and arthrodesis. The purpose of this research was to determine the impact of vancomycin on human hMSCs during the process of osteogenic differentiation...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29609860/prophylaxis-of-surgical-site-infection-in-adult-spine-surgery-a-systematic-review
#18
REVIEW
Reina Yao, Terence Tan, Jin Wee Tee, John Street
INTRODUCTION: Surgical site infection (SSI) remains a significant source of morbidity in spine surgery, with reported rates varying from 0.7 to 16%. OBJECTIVE: To systematically review and evaluate the evidence for strategies for prophylaxis of SSI in adult spine surgery in the last twenty years. METHODS: Two independent systematic searches were conducted, at two international spine centers, encompassing PubMed, ClinicalTrials.gov, Cochrane Database, EBSCO Medline, ScienceDirect, Ovid Medline, EMBASE (Ovid), and MEDLINE...
March 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29608437/intra-operative-inspired-fraction-of-oxygen-and-the-risk-of-surgical-site-infections-in-patients-with-type-1-surgical-incisions
#19
Brendan T Wanta, Kristine T Hanson, Joseph A Hyder, Thomas M Stewart, Timothy B Curry, Elie F Berbari, Elizabeth B Habermann, Daryl J Kor, Michael J Brown
BACKGROUND: Whether the fraction of inspired oxygen (FI O2 ) influences the risk of surgical site infection (SSI) is controversial. The World Health Organization and the World Federation of Societies of Anesthesiologists offer conflicting recommendations. In this study, we evaluate simultaneously three different definitions of FI O2 exposure and the risk of SSI in a large surgical population. PATIENTS AND METHODS: Patients with clean (type 1) surgical incisions who developed superficial and deep organ/space SSI within 30 days after surgery from January 2003 through December 2012 in five surgical specialties were matched to specialty-specific controls...
April 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29605279/epstein-barr-virus-associated-smooth-muscle-tumor-involving-the-spine-of-an-hiv-infected-patient-case-report-and-review-of-the-literature
#20
Jeffrey S Ehresman, A Karim Ahmed, Doreen N Palsgrove, Zachary Pennington, C Rory Goodwin, Daniel M Sciubba
Within the last two decades, there have been multiple reports of Epstein-Barr virus (EBV)-associated smooth muscle tumors in immunocompromised patients. This includes HIV-infected patients, post-transplant patients, and patients with congenital defects of their immune systems. Here we report the case of a 24-year-old African American female with congenital HIV presenting with progressive lower extremity weakness, constipation, aching pain in her shoulders, and subcostal anesthesia. Magnetic resonance imaging (MRI) revealed a large circumferential lesion extending from T1-T3 and a smaller left paraspinal lesion at C6-C7...
March 28, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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