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https://www.readbyqxmd.com/read/28944732/patient-centered-drug-approval-the-role-of-patient-advocacy-in-the-drug-approval-process
#1
T Joseph Mattingly, Linda Simoni-Wastila
Recent approval of eteplirsen for Duchenne muscular dystrophy (DMD), a rare disease with few treatment alternatives, has reignited the debate over the U.S. drug approval process. The evolution of legal and regulatory restrictions to the marketing and sale of pharmaceuticals has spanned more than a century, and throughout this history, patient advocacy has played a significant role. Scientific evidence from clinical trials serves as the foundation for drug approval, but the patient voice has become increasingly influential...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#2
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944686/remission-of-chronic-headache-rates-potential-predictors-and-the-role-of-medication-follow-up-results-of-the-german-headache-consortium-ghc-study
#3
Verena Henning, Zaza Katsarava, Mark Obermann, Susanne Moebus, Sara Schramm
Objectives To estimate remission rates of chronic headache (CH), focusing on potential predictors of headache remission and medication. Methods We used data from the longitudinal population-based German Headache Consortium (GHC) Study (n = 9,944, 18-65 years). Validated questionnaires were used at baseline (t0, 2003-2007, response rate: 55.2%), first follow-up after 1.87 ± 0.39 years (t1, 37.2%) and second follow-up after 3.26 ± 0.60 years (t2, 38.8%) to assess headache type and frequency, use of analgesics and anti-migraine drugs, medication overuse, education, BMI, smoking and alcohol consumption...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28944679/risk-and-protective-factors-for-health-related-quality-of-life-among-persons-aging-with-hiv
#4
Annie L Nguyen, Candice J McNeil, S Duke Han, Scott D Rhodes
For persons living with HIV, health-related quality of life (HRQOL) may be threatened by physical and mental conditions but may be protected by positive psychological traits. We performed an exploratory look at the risk and protective factors for HRQOL in older adults living with HIV. Cross-sectional analyses of baseline data from the Rush Center of Excellence on Disparities in HIV and Aging (CEDHA), a community-based cohort of persons ages ≥50 living with HIV (n = 176) were performed. Analyses examined the relationship between risk/protective factors and two outcomes (i...
September 25, 2017: AIDS Care
https://www.readbyqxmd.com/read/28944504/creating-and-sustaining-an-academic-practice-partnership-engagement-model
#5
Marjorie A Schaffer, Patricia M Schoon, Bonnie L Brueshoff
Public health clinical educators and practicing public health nurses (PHNs) are experiencing challenges in creating meaningful clinical learning experiences for nursing students due to an increase in nursing programs and greater workload responsibilities for both nursing faculty and PHNs. The Henry Street Consortium (HSC), a collaborative group of PHNs and nursing faculty, conducted a project to identify best practices for public health nursing student clinical learning experiences. Project leaders surveyed HSC members about preferences for teaching-learning strategies, facilitated development of resources and tools to guide learning, organized faculty/PHN pilot teams to test resources and tools with students, and evaluated the pilot team experiences through two focus groups...
September 25, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28944481/efficacy-of-dexmedetomidine-on-perioperative-morbidity-during-nasal-surgery-a-meta-analysis
#6
Se Hwan Hwang, Ho Seok Lee, Young Hoon Joo, Jae Hyun Seo, Jun Myung Kang
OBJECTIVES: The goal of this meta-analysis was to perform a systematic review of the literature on the effect of dexmedetomidine on perioperative morbidity following nasal surgery and on the adverse effects of dexmedetomidine. DATA SOURCES: MEDLINE, Scopus, and Cochrane Database of Systematic Reviews. REVIEW METHODS: Two authors independently searched scientific and medical databases from their inception of article collection to March 2017...
September 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28944453/personalised-digital-interventions-for-reducing-hazardous-and-harmful-alcohol-consumption-in-community-dwelling-populations
#7
REVIEW
Eileen Fs Kaner, Fiona R Beyer, Claire Garnett, David Crane, Jamie Brown, Colin Muirhead, James Redmore, Amy O'Donnell, James J Newham, Frank de Vocht, Matthew Hickman, Heather Brown, Gregory Maniatopoulos, Susan Michie
BACKGROUND: Excessive alcohol use contributes significantly to physical and psychological illness, injury and death, and a wide array of social harm in all age groups. A proven strategy for reducing excessive alcohol consumption levels is to offer a brief conversation-based intervention in primary care settings, but more recent technological innovations have enabled people to interact directly via computer, mobile device or smartphone with digital interventions designed to address problem alcohol consumption...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944405/knowledge-and-attitudes-toward-cancer-pain-management-among-nurses-at-oncology-units
#8
Malek Khalel Alnajar, Muhammad W Darawad, Sandi Sami Alshahwan, Osama A Samarkandi
Nurses have major responsibilities to treat cancer pain in an optimal way. Their knowledge and attitudes are the key to success cancer pain management (CPM) process and impact the outcomes of pain treatment. This study aimed to evaluate the knowledge and attitudes toward CPM among Jordanian nurses working at oncology units. A cross-sectional descriptive design was used to collect data from 135 nurses who were working at four oncology units using Knowledge and Attitudes Survey Regarding Pain. The percentage of correct answers was 51...
September 24, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28944292/early-head-start-pediatric-dental-use-and-oral-health-related-quality-of-life
#9
J M Burgette, J S Preisser, M Weinberger, R S King, R G Rozier
The objective of the study was to examine the mediating effect of child dental use on the effectiveness of North Carolina Early Head Start (EHS) in improving oral health-related quality of life (OHRQoL). In total, 479 parents of children enrolled in EHS and 699 parents of Medicaid-matched children were interviewed at baseline when children were approximately 10 mo old and 24 mo later. In this quasi-experimental study, mediation analysis was performed using the counterfactual framework analysis, which employed 2 logit models with random effects: 1) for the mediator as a function of the treatment and covariates and 2) for the outcome as a function of the treatment, mediator, and covariates...
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28944289/video-intervention-increases-participation-of-black-breast-cancer-patients-in-therapeutic-trials
#10
Brandi N Robinson, Antoinette F Newman, Eshetu Tefera, Pia Herbolsheimer, Raquel Nunes, Christopher Gallagher, Pamela Randolph-Jackson, Adedamola Omogbehin, Asma Dilawari, Paula R Pohlmann, Mahsa Mohebtash, Young Lee, Yvonne Ottaviano, Avani Mohapatra, Filipa Lynce, Richard Brown, Mihriye Mete, Sandra M Swain
There is a striking racial and ethnic disparity in incidence and mortality of cancer yet minorities remain markedly underrepresented in clinical trials. This pilot study set out to determine the impact of a 15-min culturally tailored educational video on three outcomes relating to clinical trials: likely participation, attitudes (assessed based on six barriers), and actual enrollment. Breast cancer patients with Stage I-III, if diagnosed within previous 6 months, or metastatic disease who self-identified as black or African American were invited to participate...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28944250/predictors-of-hip-pain-and-function-in-femoroacetabular-impingement-a-prospective-cohort-analysis
#11
Robert W Westermann, T Sean Lynch, Morgan H Jones, Kurt P Spindler, William Messner, Greg Strnad, James Rosneck
BACKGROUND: Validated patient-reported outcome measures (PROMs) of hip pain and function at the time of arthroscopy could be predictors of the final outcome. Little is known about how patient factors or pathologic intra-articular findings relate to hip pain or function at the time of surgery for those presenting with femoroacetabular impingement (FAI). PURPOSE: To evaluate all patient and operative factors that contribute to hip pain and dysfunction in patients with FAI...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944055/understanding-the-links-between-resilience-and-type-2-diabetes-self-management-a-qualitative-study-in-south-australia
#12
A L Wilson, D McNaughton, S B Meyer, P R Ward
BACKGROUND: Research conducted by Ward, Muller, Tsourtos, et al. (Soc Sci Med 72(7):1140-1148, 2011) has led to the development of the psycho-social interactive model of resilience, which reveals the interaction between individual resilience factors (i.e. coping, confidence and self esteem) and external resilience environments (i.e. employment, supportive family environments and health promoting policies) in facilitating the development of resilience. This present study explored the utility of this model of resilience for understanding how people self-manage type-2 diabetes...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28943985/the-impact-of-pharmacist-led-medication-therapy-management-on-medication-adherence-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-study
#13
Daniel A Erku, Asnakew A Ayele, Abebe B Mekuria, Sewunet A Belachew, Bisrat Hailemeskel, Henok G Tegegn
BACKGROUND: Poor adherence to antidiabetic medications leads to a higher rate of hospital admissions and adverse health outcomes in type 2 diabetes mellitus patients. OBJECTIVE: This study aims to evaluate whether a pharmacist-led medication therapy management, compared to the usual care, could enhance medication adherence and reduce hospital admission in patients with type 2 diabetes mellitus. METHODS: A prospective randomized controlled study was conducted in patients with type 2 diabetes mellitus from February 1 to July 30, 2016...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943830/the-clinical-implications-of-youth-sports-concussion-laws-a-review
#14
Jeneita M Bell, Christina L Master, Michael R Lionbarger
The recent passage of state youth sports concussion laws across the country introduces clinical implications for health care professionals caring for student-athletes. Although the laws were established to provide protections for student-athletes and prevent adverse outcomes, efforts aimed at implementation have uncovered various challenges in concussion diagnosis and management. Some of the most salient issues include medical evaluation, return to play, and return to learn. For this reason, health care professionals play a pivotal role in determining the critical next steps after a student is removed from play with a suspected concussion...
2017: American Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/28943825/can-a-short-video-improve-inhaler-use-in-urban-youth
#15
Sara Brown, Victoria Tutag Lehr, Nathan French, Christopher Alan Giuliano
OBJECTIVE: The primary aim was to determine whether watching a short video in the inpatient setting could produce an immediate improvement in pediatric patients' asthma knowledge and inhaler technique. METHODS: This prospective, quasi-experimental, pre-post study was conducted in a single center, in Detroit, Michigan, which primarily serves an urban, African-American population. Patients were eligible if they were between 8- and 16-years-old, had asthma, and would be discharged with an albuterol metered-dose inhaler...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28943804/treatment-in-the-home-setting-with-intermittent-pneumatic-compression-for-a-woman-with-chronic-leg-ulcers-a-case-report
#16
Katrina Young, Harrison Ng Chok, Lesley Wilkes
BACKGROUND: Intermittent Pneumatic Compression (IPC) is shown to improve the healing rate of Venous Leg Ulcers (VLU) in the hospital setting. The current Australian "Gold Standard" treatment according to the Australian and New Zealand Wound Management Associations' (AWMA) Prevention & Management of Venous Leg Ulcer guidelines is compression, generally in the form of bandaging then progressing to hosiery once wounds are healed to prevent recurrence. This is recommended in conjunction with other standards of wound management including; nutrition, exercise, client education and addressing underlying pathophysiology and psychosocial factors...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28943746/educator-of-the-court-the-role-of-the-expert-witness-in-cases-involving-autism-spectrum-disorder
#17
Colleen M Berryessa
The role of the expert witness in legal contexts is to educate fact finders of the court who may have no background in the expert's area. This role can be especially difficult for those who assist in cases involving individuals with Autism Spectrum Disorder (ASD). As expert assistance on ASD is crucial to ensuring just outcomes for individuals diagnosed with ASD, knowledge on how expert witnesses perceive and approach their roles, and what factors may influence these perceptions, is essential. This qualitative research utilizes semi-structured interviews with a sample of expert witnesses in cases involving ASD, analyzed using a grounded-theory constant comparative analytic approach...
2017: Psychology, Crime & Law: PC & L
https://www.readbyqxmd.com/read/28942611/global-sensory-impairment-predicts-morbidity-and-mortality-in-older-u-s-adults
#18
Jayant M Pinto, Kristen E Wroblewski, Megan Huisingh-Scheetz, Camil Correia, Kevin J Lopez, Rachel C Chen, David W Kern, Philip L Schumm, William Dale, Martha K McClintock
OBJECTIVES: To evaluate global sensory impairment (GSI, an integrated measure of sensory dysfunction) as a predictor of physical function, cognition, overall health, and mortality. DESIGN: Prospective study. SETTING: The National Social Life, Health, and Aging Project. PARTICIPANTS: A national probability sample of 3,005 home-dwelling older U.S. adults assessed at baseline (2005-06) and 5-year follow-up (2010-11). MEASUREMENTS: Gait speed, activity, disability, cognition, overall health, 5-year mortality...
September 24, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28942437/assessment-of-health-literacy-with-the-newest-vital-sign-and-its-correlation-with-body-mass-index-in-female-adolescent-students
#19
Samira Olyani, Hadi Tehrani, Habibullah Esmaily, Mohammadreza Mohammadzadeh Rezaii, Mohammad Vahedian-Shahroodi
Background One of the significant outcomes of health education is health literacy (HL), which should be expanded to improve health promotion. Objective The aim of this study was to assess HL and its relationship with Body Mass Index (BMI) in female adolescent students. Subjects This study was conducted on 235 female students (aged 13-15 years) which were selected with cluster sampling. Methods For assessing HL, the Newest Vital Sign (NVS) was used and BMI Z-score was evaluated following the World Health Organization (WHO) guidelines...
September 25, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28942289/polysubstance-use-by-psychiatry-inpatients-with-co-occurring-mental-health-and-substance-use-disorders
#20
Christine Timko, Mark Ilgen, Marie Haverfield, Alexandra Shelley, Jessica Y Breland
BACKGROUND: Polysubstance use, the consumption of more than one substance over a defined period, is common and associated with psychiatric problems and poor treatment adherence and outcomes. This study examined past-month polysubstance use at intake among psychiatry inpatients with co-occurring mental health and substance use disorders, and outcomes 3 months later. METHODS: Participants (n=406 psychiatry inpatients with documented mental health and substance use disorders) completed a baseline and a 3-month follow-up (84%) interview...
September 15, 2017: Drug and Alcohol Dependence
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