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https://www.readbyqxmd.com/read/28097310/combined-intravenous-thrombolysis-and-thrombectomy-vs-thrombectomy-alone-for-acute-ischemic-stroke-a-pooled-analysis-of-the-swift-and-star-studies
#1
Jonathan M Coutinho, David S Liebeskind, Lee-Anne Slater, Raul G Nogueira, Wayne Clark, Antoni Dávalos, Alain Bonafé, Reza Jahan, Urs Fischer, Jan Gralla, Jeffrey L Saver, Vitor M Pereira
Importance: Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known whether intravenous thrombolysis (IVT) is of added benefit in patients undergoing MT. Objective: To examine whether treatment with IVT before MT with a stent retriever is beneficial in patients undergoing MT. Design, Setting, and Participants: This post hoc analysis used data from 291 patients treated with MT included in 2 large, multicenter, prospective clinical trials that evaluated MT for AIS (Solitaire With the Intention for Thrombectomy performed from January 1, 2010, through December 31, 2011, and Solitaire Flow Restoration Thrombectomy for Acute Revascularization from January 1, 2010, through December 31, 2012)...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28093637/exploring-differences-in-adverse-symptom-event-grading-thresholds-between-clinicians-and-patients-in-the-clinical-trial-setting
#2
Thomas M Atkinson, Lauren J Rogak, Narre Heon, Sean J Ryan, Mary Shaw, Liora P Stark, Antonia V Bennett, Ethan Basch, Yuelin Li
PURPOSE: Symptomatic adverse event (AE) monitoring is essential in cancer clinical trials to assess patient safety, as well as inform decisions related to treatment and continued trial participation. As prior research has demonstrated that conventional concordance metrics (e.g., intraclass correlation) may not capture nuanced aspects of the association between clinician and patient-graded AEs, we aimed to characterize differences in AE grading thresholds between doctors (MDs), registered nurses (RNs), and patients using the Bayesian Graded Item Response Model (GRM)...
January 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28077332/molecular-identification-of-star-and-3%C3%AE-hsd1-and-characterization-in-response-to-gnih-stimulation-in-protogynous-hermaphroditic-grouper-epinephelus-coioides
#3
Qingqing Wang, Xin Qi, Haipei Tang, Yin Guo, Shuisheng Li, Gaofei Li, Xiaoli Yang, Haifa Zhang, Xiaochun Liu, Haoran Lin
Gonadal steroids are critical factors in reproduction and sex reverse process. StAR (steroidogenic acute regulatory protein), transferring the cholesterol from the outer mitochondrial membrane to the inner membrane, is the rate-limiting factor of steroidogenesis. 3βHSD (3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase), converting Δ5-steroids into Δ4-steroids, is an important oxidoreductase in steroidogenesis. In the present study, StAR and 3βHSD1 were cloned and characterized from protogynous orange-spotted grouper...
January 8, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28063193/influence-of-protein-fermentation-and-carbohydrate-source-on-in%C3%A2-vitro-methane-production
#4
J L Vanegas, J González, M D Carro
Incubations were carried out with batch cultures of ruminal micro-organisms from sheep to analyse the influence of the N source on in vitro CH4 production. The two substrates were mixtures of maize starch and cellulose in proportions of 75:25 and 25:75 (STAR and CEL substrates, respectively), and the three nitrogen (N) sources were ammonia (NH4 Cl), casein (CA) and isolated soya bean protein (SP). Five isonitrogenous treatments were made by replacing non-protein-N (NPN) with CA or SP at levels of 0 (NPN), 50 (CA50 and SP50, respectively) and 100% (CA100 and SP100) of total N...
January 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28062678/facility-practice-variation-to-help-understand-the-effects-of-public-policy-insights-from-the-dialysis-outcomes-and-practice-patterns-study-dopps
#5
Douglas S Fuller, Bruce M Robinson
Recent Centers for Medicare & Medicaid Services policies have used dialysis facility practice variation to develop public ratings and adjust payments. In the Dialysis Facility Compare star rating system (DFC SRS), facility-relative rates of performance-based clinical measures varied nearly two-fold for mortality (standardized mortality ratio; 10th/90th percentiles: 0.71, 1.34) and hospitalization (standardized hospitalization ratio; 10th/90th percentiles: 0.64, 1.37), and nearly four-fold for transfusion (standardized transfusion ratio; 10th/90th percentiles: 0...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28059260/effective-star-tracking-method-based-on-optical-flow-analysis-for-star-trackers
#6
Ting Sun, Fei Xing, Xiaochu Wang, Jin Li, Minsong Wei, Zheng You
Benefiting from rapid development of imaging sensor technology, modern optical technology, and a high-speed computing chip, the star tracker's accuracy, dynamic performance, and update rate have been greatly improved with low power consumption and miniature size. The star tracker is currently one of the most competitive attitude measurement sensors. However, due to restrictions of the optical imaging system, difficulties still exist in moving star spot detection and star tracking when in special motion conditions...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28059234/multiexposure-imaging-and-parameter-optimization-for-intensified-star-trackers
#7
Wenbo Yu, Jie Jiang, Guangjun Zhang
Due to the introduction of the intensified image detector, the dynamic performance of the intensified star tracker is effectively improved. However, its attitude update rate is still seriously restricted by the transmission and processing of pixel data. In order to break through the above limitation, a multiexposure imaging approach for intensified star trackers is proposed in this paper. One star image formed by this approach actually records N different groups of star positions, and then N corresponding groups of attitude information can be acquired...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28049472/implementation-of-a-recovery-oriented-model-in-a-sub-acute-intermediate-stay-mental-health-unit-ismhu
#8
Barry G Frost, Megan Turrell, Ketrina A Sly, Terry J Lewin, Agatha M Conrad, Suzanne Johnston, Srinivasan Tirupati, Kerry Petrovic, Sadanand Rajkumar
BACKGROUND: An ongoing service evaluation project was initiated following the establishment of a new, purpose-built, 20-bed sub-acute Intermediate Stay Mental Health Unit (ISMHU). This paper: provides an overview of the targeted 6-week program, operating within an Integrated Recovery-oriented Model (IRM); characterises the clients admitted during the first 16 months; and documents their recovery needs and any changes. METHODS: A brief description of the unit's establishment and programs is initially provided...
January 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28046211/su-d-bra-07-applications-of-combined-kv-mv-cbct-imaging-with-a-high-dqe-mv-detector
#9
M Bazalova-Carter, A Wang, M Wu, M Newson, L Xing, W Ansbacher, R Fahrig, J Star-Lack
PURPOSE: To investigate whether a high detection quantum efficiency (DQE) MV detector makes combined kV/MV CBCT clinically practical. METHODS: Combined kV/MV CBCT was studied for scan time reduction (STR) and metal artifact reduction (MAR). 6MV CBCT data (dose rate = 0.017 MU/degree) were collected using 1) a novel focused pixelated cadmium tungstate (CWO) scintillator (15mm thickness, DQE(0) = 22%, 0.784mm pixel pitch) coupled to a flat panel imager, and 2) a commercial portal imager with a 133mg/cm(2) gadolinium oxysulfide (GOS) screen (DQE(0) = 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025924/improving-comprehensive-medication-review-acceptance-by-using-a-standardized-recruitment-script-a-randomized-control-trial
#10
Alexander Miguel, Anna Hall, Wei Liu, Jeremy Garrett, Angel Ballew, Tsu-Hsaun Yang, Richard Segal
BACKGROUND: The Centers for Medicare & Medicaid Services (CMS) require prescription drug plan sponsors to offer a comprehensive medication review (CMR) annually to eligible beneficiaries through the plans' Medication Therapy Management Programs (MTMPs). In 2011, the Pharmacy Quality Alliance endorsed the CMR completion rate as a quality measure for MTMPs, and CMS has adopted the measure into the 2016 CMS star ratings. CMS star ratings are used to describe the quality of plans to assist Medicare plan enrollees in choosing a plan and to determine quality bonus payments for Medicare Advantage plans...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28025922/comprehensive-medication-reviews-in-long-term-care-facilities-history-of-process-implementation-and-2015-results
#11
Terrence E O'Shea, Barbara J Zarowitz, W Gary Erwin
BACKGROUND: Since 2013, Part D sponsors have been required to offer comprehensive medication reviews (CMRs) to all beneficiaries enrolled in their medication therapy management (MTM) programs at least annually, including those in long-term care (LTC) settings. Since that time, MTM providers have found that accessing and completing CMRs with beneficiaries is frequently prohibitively complex, since the process often requires a live, face-to-face interactive interview where the beneficiary resides...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28024698/interpreting-survival-data-from-clinical-trials-of-surgery-versus-stereotactic-body-radiation-therapy-in-operable-stage-i-non-small-cell-lung-cancer-patients
#12
Pamela Samson, Kathleen Keogan, Traves Crabtree, Graham Colditz, Stephen Broderick, Varun Puri, Bryan Meyers
OBJECTIVES: To identify the variability of short- and long-term survival outcomes among closed Phase III randomized controlled trials with small sample sizes comparing SBRT (stereotactic body radiation therapy) and surgical resection in operable clinical Stage I non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Clinical Stage I NSCLC patients who underwent surgery at our institution meeting the inclusion/exclusion criteria for STARS (Randomized Study to Compare CyberKnife to Surgical Resection in Stage I Non-small Cell Lung Cancer), ROSEL (Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer), or both were identified...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28009923/shape-tunable-pt-ir-alloy-nanocatalysts-with-high-performance-in-oxygen-electrode-reactions
#13
Tao Zhang, Shuai-Chen Li, Wei Zhu, Zhi-Ping Zhang, Jun Gu, Ya-Wen Zhang
For the first time, shape-tunable Pt-Ir alloy nanocatalysts including both single-crystalline (nano-octahedra (NOs), nano-truncated octahedra (NTOs), nanocubes (NCs)) and polycrystalline (nanocluster flowers (NCFs), nanowires (NWs), nano-short-chains (NSCs), and nano-octahedral stars (NOSs)) ones were synthesized with a facile one-pot solvothermal method, via precise control of the facet-selective agents (Br(-) and I(-)). The surface effects of Pt-Ir alloy nanocatalysts for oxygen electrode reaction in acidic solution were intensively investigated...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28009216/constraints-on-ultrahigh-energy-cosmic-ray-sources-from-a-search-for-neutrinos-above-10%C3%A2-pev-with-icecube
#14
M G Aartsen, K Abraham, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, M Archinger, C Argüelles, J Auffenberg, S Axani, X Bai, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, M Bissok, E Blaufuss, S Blot, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Braun, L Brayeur, H-P Bretz, A Burgman, T Carver, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, R Cross, M Day, J P A M de André, C De Clercq, E Del Pino Rosendo, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, P Eller, S Euler, P A Evenson, S Fahey, A R Fazely, J Feintzeig, J Felde, K Filimonov, C Finley, S Flis, C-C Fösig, A Franckowiak, E Friedman, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, K Ghorbani, W Giang, L Gladstone, M Glagla, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, D Grant, Z Griffith, C Haack, A Haj Ismail, A Hallgren, F Halzen, E Hansen, B Hansmann, T Hansmann, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, K Holzapfel, K Hoshina, F Huang, M Huber, K Hultqvist, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, M Jurkovic, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, J Kemp, A Kheirandish, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, R Konietz, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, C Krüger, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, M Labare, J L Lanfranchi, M J Larson, F Lauber, D Lennarz, M Lesiak-Bzdak, M Leuermann, J Leuner, L Lu, J Lünemann, J Madsen, G Maggi, K B M Mahn, S Mancina, M Mandelartz, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, A Meli, T Menne, G Merino, T Meures, S Miarecki, L Mohrmann, T Montaruli, M Moulai, R Nahnhauer, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, Ö Penek, J A Pepper, C Pérez de Los Heros, D Pieloth, E Pinat, P B Price, G T Przybylski, M Quinnan, C Raab, L Rädel, M Rameez, K Rawlins, R Reimann, B Relethford, M Relich, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, L Sabbatini, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, K Satalecka, M Schimp, P Schlunder, T Schmidt, S Schoenen, S Schöneberg, L Schumacher, D Seckel, S Seunarine, D Soldin, M Song, G M Spiczak, C Spiering, M Stahlberg, T Stanev, A Stasik, A Steuer, T Stezelberger, R G Stokstad, A Stößl, R Ström, N L Strotjohann, G W Sullivan, M Sutherland, H Taavola, I Taboada, J Tatar, F Tenholt, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, A Turcati, E Unger, M Usner, J Vandenbroucke, N van Eijndhoven, S Vanheule, M van Rossem, J van Santen, J Veenkamp, M Vehring, M Voge, M Vraeghe, C Walck, A Wallace, M Wallraff, N Wandkowsky, Ch Weaver, M J Weiss, C Wendt, S Westerhoff, B J Whelan, S Wickmann, K Wiebe, C H Wiebusch, L Wille, D R Williams, L Wills, M Wolf, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, M Zoll
We report constraints on the sources of ultrahigh-energy cosmic rays (UHECRs) above 10^{9}  GeV, based on an analysis of seven years of IceCube data. This analysis efficiently selects very high- energy neutrino-induced events which have deposited energies from 5×10^{5}  GeV to above 10^{11}  GeV. Two neutrino-induced events with an estimated deposited energy of (2.6±0.3)×10^{6}  GeV, the highest neutrino energy observed so far, and (7.7±2.0)×10^{5}  GeV were detected. The atmospheric background-only hypothesis of detecting these events is rejected at 3...
December 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27999322/a-modified-magnetic-gradient-contraction-based-method-for-ferromagnetic-target-localization
#15
Chen Wang, Xiaojuan Zhang, Xiaodong Qu, Xiao Pan, Guangyou Fang, Luzhao Chen
The Scalar Triangulation and Ranging (STAR) method, which is based upon the unique properties of magnetic gradient contraction, is a high real-time ferromagnetic target localization method. Only one measurement point is required in the STAR method and it is not sensitive to changes in sensing platform orientation. However, the localization accuracy of the method is limited by the asphericity errors and the inaccurate value of position leads to larger errors in the estimation of magnetic moment. To improve the localization accuracy, a modified STAR method is proposed...
December 17, 2016: Sensors
https://www.readbyqxmd.com/read/27991746/rural-medicare-advantage-market-dynamics-and-quality-historical-context-and-current-implications
#16
Leah Kemper, Abigail R Barker, Lyndsey Wilber, Timothy D McBride, Keith Mueller
Purpose. In this policy brief, we assess variation in Medicare’s star quality ratings of Medicare Advantage (MA) plans that are available to rural beneficiaries. Evidence from the recent Centers for Medicare & Medicaid Services (CMS) quality demonstration suggests that market dynamics, i.e., firms entering and exiting the MA marketplace, play a role in quality improvement. Therefore, we also discuss how market dynamics may impact the smaller and less wealthy populations that are characteristic of rural places...
2016: Rural Policy Brief
https://www.readbyqxmd.com/read/27976807/under-reporting-of-suicide-ideation-in-us-army-population-screening-an-ongoing-challenge
#17
Steven D Vannoy, Bonnie K Andrews, David C Atkins, Katherine A Dondanville, Stacey Young-McCaughan, Alan L Peterson
Previous research in US Army Soldiers shows rates of mental health concerns as two to four times higher on anonymous surveys than on postdeployment health assessments. In this study, Soldiers presenting for health reassessment completed two questionnaires on suicide risk factors: one linked to the health assessment and one anonymous. About 5.1% of respondents reported suicide ideation on the anonymous questionnaire, 3.0% on the linked questionnaire, and 0.9% on the health reassessment. About 56.4% who reported suicide ideation anonymously told nobody of their thoughts...
December 15, 2016: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/27974869/community-level-association-between-home-health-and-nursing-home-performance-on-quality-and-hospital-30-day-readmissions-for-medicare-patients
#18
Yun Wang, Michelle M Pandolfi, Jonathan Fine, Mark L Metersky, Changqin Wang, Shih-Yieh Ho, Deron Galusha, Sudhakar V Nuti, Karthik Murugiah, Ann Spenard, Timothy Elwell, Harlan M Krumholz
We evaluated whether community-level home health agencies and nursing home performance is associated with community-level hospital 30-day all-cause risk-standardized readmission rates for Medicare patients used data from the Centers for Medicare & Medicaid Service from 2010 to 2012. Our final sample included 2,855 communities that covered 4,140 hospitals with 6,751,713 patients, 13,060 nursing homes with 1,250,648 residents, and 7,613 home health agencies providing services to 35,660 zipcodes. Based on a mixed effect model, we found that increasing nursing home performance by one star for all of its 4 measures and home health performance by 10 points for all of its 6 measures is associated with decreases of 0...
November 2016: Home Health Care Management & Practice
https://www.readbyqxmd.com/read/27968847/bushenjianpi-formula-combined-with-entecavir-for-hbeag-negative-chronic-hepatitis-b-patients-a-multicentre-randomised-double-blind-placebo-controlled-trial
#19
Yue-Qiu Gao, Xin Zhang, Man Li, Zhen-Hua Zhou, Xue-Hua Sun, Xiao-Jun Zhu, Shu-Gen Jin
BACKGROUND: The treatment combination of traditional Chinese medicine with western medicine results in significant decrease of serum hepatitis B virus (HBV) DNA and increase of HBeAg loss in patients with HBeAg-positive chronic hepatitis B (CHB) without any serious adverse events. We aimed to assess whether the Bushenjianpi Formula combined with entecavir could increase the HBsAg loss rate in patients with HBeAg-negative CHB. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, we recruited patients with HBeAg-negative CHB from ten third-level grade-A hospital of Traditional Chinese Medicine...
October 2016: Lancet
https://www.readbyqxmd.com/read/27959927/ridge-polynomial-neural-network-with-error-feedback-for-time-series-forecasting
#20
Waddah Waheeb, Rozaida Ghazali, Tutut Herawan
Time series forecasting has gained much attention due to its many practical applications. Higher-order neural network with recurrent feedback is a powerful technique that has been used successfully for time series forecasting. It maintains fast learning and the ability to learn the dynamics of the time series over time. Network output feedback is the most common recurrent feedback for many recurrent neural network models. However, not much attention has been paid to the use of network error feedback instead of network output feedback...
2016: PloS One
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