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https://www.readbyqxmd.com/read/28295552/high-resolution-dynamic-oxygen-17-mr-imaging-of-mouse-brain-with-golden-ratio-based-radial-sampling-and-k-space-weighted-image-reconstruction
#1
Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Nicholas Tomko, Mikhail D Linetsky, Robert G Salomon, Ciro Ramos-Estebanez, Yanming Wang, Xin Yu
PURPOSE: The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 ((17) O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of (17) O water uptake and washout in the brains of mice with glioblastoma (GBM). METHODS: A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire (17) O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution...
March 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28294685/star-anise-illicium-verum-hook-f-as-quorum-sensing-and-biofilm-formation-inhibitor-on-foodborne-bacteria-study-in-milk
#2
Md Ramim Tanver Rahman, Zaixiang Lou, Jun Zhang, Fuhao Yu, Yakindra Prasad Timilsena, Caili Zhang, Yi Zhang, Amr M Bakry
Bacteria use quorum sensing (QS) systems to communicate with each other and regulate microbial group behavior, such as the secretion of virulence factors, including biofilm formation. In order to explore safe, edible agents, the potential of star anise (SA) as an anti-QS and antibiofilm agent and its possible application in milk safety were investigated. Staphylococcus aureus , Salmonella Typhimurium, Pseudomonas aeruginosa , and biosensor strain Chromobacterium violaceum were selected as test strains for QS, biofilm, and exopolysaccharide assays...
March 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28294168/assessment-of-the-construct-validity-of-the-australian-health-star-rating-a-nutrient-profiling-diagnostic-accuracy-study
#3
S L Cooper, F E Pelly, J B Lowe
BACKGROUND/OBJECTIVES: Nutrient profiling models classify the healthiness of foods based on their nutritional composition and provide the science that underlies nutrition signposting schemes. The two objectives were to examine the construct validity of the Health Star Rating (HSR) system by determining its diagnostic accuracy and to detect the optimal HSR cutoff points to define healthiness in packaged dairy foods. We hypothesised that ultra-processed dairy, defined by NOVA, would have less stars (less healthy) and non-ultra-processed dairy would have more stars (more healthy)...
March 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28293102/paclitaxel-loaded-star-shaped-copolymer-nanoparticles-for-enhanced-malignant-melanoma-chemotherapy-against-multidrug-resistance
#4
Yongsheng Su, Jian Hu, Zhibin Huang, Yubin Huang, Bingsheng Peng, Ni Xie, Hui Liu
Malignant melanoma (MM) is the most dangerous type of skin cancer with annually increasing incidence and death rates. However, chemotherapy for MM is restricted by low topical drug concentration and multidrug resistance. In order to surmount the limitation and to enhance the therapeutic effect on MM, a new nanoformulation of paclitaxel (PTX)-loaded cholic acid (CA)-functionalized star-shaped poly(lactide-co-glycolide) (PLGA)-D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoparticles (NPs) (shortly PTX-loaded CA-PLGA-TPGS NPs) was fabricated by a modified method of nanoprecipitation...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28285078/biodegradable-inorganic-organic-hybrids-of-methacrylate-star-polymers-for-bone-regeneration
#5
Justin J Chung, Yuki Fujita, Siwei Li, Molly M Stevens, Toshihiro Kasuga, Theoni K Georgiou, Julian R Jones
Hybrids that are molecular scale co-networks of organic and inorganic components are promising biomaterials, improving the brittleness of bioactive glass and the strength of polymers. Methacrylate polymers have high potential as the organic source for hybrids since they can be produced, through controlled polymerization, with sophisticated polymer architectures that can bond to silicate networks. Previous studies showed the mechanical properties of hybrids can be modified by polymer architecture and molar mass (MM)...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28285064/patient-perceptions-of-a-pharmacy-star-rating-model
#6
Terri L Warholak, Mira Patel, Meagen Rosenthal, Donna West-Strum, Earl B Ettienne, Gail Nunlee-Bland, David Nau, Ana L Hincapie
OBJECTIVES: To identify patients' understanding of what constitutes a "quality pharmacy" and to obtain their feedback regarding the development and use of the pharmacy star rating model, a pharmacy-specific aggregate performance score based on the Centers for Medicare and Medicaid Services' Medicare Star Rating. DESIGN: Prospective cross-sectional study. SETTING AND PARTICIPANTS: Focus groups were conducted in Arizona, California, Mississippi, Maryland, and the District of Columbia, and one-on-one interviews were conducted in Indiana...
March 8, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28283663/ligo-and-the-opening-of-a-unique-observational-window-on-the-universe
#7
Vassiliki Kalogera, Albert Lazzarini
A unique window on the universe opened on September 14, 2015, with direct detection of gravitational waves by the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) detectors. This event culminated a half-century effort around the globe to develop terrestrial detectors of adequate sensitivity to achieve this goal. It also happened appropriately only a few months before the centennial of Einstein's final paper introducing the general theory of relativity. This detection provided the surprising discovery of a coalescing pair of "heavy" black holes (more massive than [Formula: see text] M[Formula: see text]) leading to the formation of a spinning [Formula: see text]62 solar mass black hole...
March 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28270210/understanding-and-acceptability-by-hispanic-consumers-of-four-front-of-pack-food-labels
#8
Vanessa De la Cruz-Góngora, Pilar Torres, Alejandra Contreras-Manzano, Alejandra Jáuregui de la Mota, Verónica Mundo-Rosas, Salvador Villalpando, Guadalupe Rodríguez-Oliveros
BACKGROUND: Front-of-pack food labels (FOPL) can help consumers make healthy and informed food choices. FOPL are used in the food market but evaluations of their understanding and acceptability are scanty. This study aimed to explore the subjective understanding and acceptability of four FOPL among Hispanic consumers. METHODS: A qualitative study was conducted in six States of Mexico, in 18 urban elementary schools. A purposive sample of 135 parents of fifth-grade children was selected...
March 7, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28263815/the-optimal-rate-for-resolving-a-near-polytomy-in-a-phylogeny
#9
Mike Steel, Christoph Leuenberger
The reconstruction of phylogenetic trees from discrete character data typically relies on models that assume the characters evolve under a continuous-time Markov process operating at some overall rate λ. When λ is too high or too low, it becomes difficult to distinguish a short interior edge from a polytomy (the tree that results from collapsing the edge). In this note, we investigate the rate that maximizes the expected log-likelihood ratio (i.e. the Kullback-Leibler separation) between the four-leaf unresolved (star) tree and a four-leaf binary tree with interior edge length ϵ...
March 3, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28263369/hospital-variation-in-rates-of-new-institutionalizations-within-6-months-of-discharge
#10
Addie Middleton, Jie Zhou, Kenneth J Ottenbacher, James S Goodwin
OBJECTIVES: Hospitalization in community-dwelling elderly is often accompanied by functional loss, increasing the risk for continued functional decline and future institutionalization. The primary objective of our study was to examine the hospital-level variation in rates of new institutionalizations among Medicare beneficiaries. DESIGN: Retrospective cohort study. SETTING: Hospitals and nursing homes. PARTICIPANTS: Medicare fee-for-service beneficiaries discharged from 4,469 hospitals in 2013 (N = 4,824,040)...
March 6, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28260126/neuroplasticity-and-second-messenger-pathways-in-antidepressant-efficacy-pharmacogenetic-results-from-a-prospective-trial-investigating-treatment-resistance
#11
Chiara Fabbri, Concetta Crisafulli, Raffaella Calati, Diego Albani, Gianluigi Forloni, Marco Calabrò, Rosalba Martines, Siegfried Kasper, Joseph Zohar, Alzbeta Juven-Wetzler, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Alessandro Serretti
Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous findings in an independent sample with treatment-resistant depression (TRD), and (2) to perform a pathway analysis to investigate the possible molecular mechanisms involved. 220 patients with major depressive disorder who were non-responders to a previous antidepressant were treated with venlafaxine for 4-6 weeks and in case of non-response with escitalopram for 4-6 weeks...
March 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28259380/loop-versus-divided-colostomy-for-the-management-of-anorectal-malformations-a-systematic-review-and-meta-analysis
#12
Fouad Youssef, Ghaidaa Arbash, Pramod S Puligandla, Robert J Baird
BACKGROUND: The ideal colostomy type for patients with anorectal malformations (ARM) is undetermined. We performed a systematic review and meta-analysis of short-term complications comparing loop and divided colostomies. METHODS: After review registration (PROSPERO: CRD42016036481), multiple databases were searched for comparative studies without language or date restrictions. Gray literature was sought. Complications investigated included stomal prolapse/hernia/retraction, wound infections, and urinary tract infections (UTIs)...
February 20, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28257863/effects-of-selenium-on-the-proliferation-apoptosis-and-testosterone-production-of-sheep-leydig-cells-in%C3%A2-vitro
#13
Lei Shi, Ruigao Song, Xiaolei Yao, Youshe Ren
The objective of this study was to investigate the effects of selenium (Se) on in vitro proliferation, apoptosis and testosterone production of sheep Leydig cells and its underlying mechanism. Leydig cells were collected from 8-month-old sheep and divided into four treatment groups (0, 2.0, 4.0 and 8.0 μmol/L Se). After treatment with Se for 48 h, the MTT and flow cytometric assay were used to detect cell proliferation and apoptosis. Testosterone level in the culture medium was determined by ELISA. The mRNA expression and protein abundance of cell cycle, apoptosis and testosterone synthesis-related genes were detected using real-time PCR and western blot analysis...
April 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28247177/technical-efficiency-of-nursing-homes-do-five-star-quality-ratings-matter
#14
Rajendra Dulal
This study investigates associations between five-star quality ratings and technical efficiency of nursing homes. The sample consists of a balanced panel of 338 nursing homes in California from 2009 through 2013 and uses two-stage data envelopment (DEA) analysis. The first-stage applies an input oriented variable returns to scale DEA analysis. The second-stage uses a left censored random-effect Tobit regression model. The five-star quality ratings i.e., health inspections, quality measures, staffing available on the Nursing Home Compare website are divided into two categories: outcome and structure form of quality...
February 28, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28246494/proposed-score-for-the-self-assessment-of-an-endoscopy-department-performance-in-colonoscopy-screening
#15
Ioan Sporea, Alina Popescu, Roxana Sirli, Oliviu Pascu, Cristina Cijevschi Prelipcean, Daniela Dobru, Simona Bota, Diana Gherhardt, Oana Gradinaru, Madalina Popescu
The aim of the paper was to propose a score for performance evaluation in colonoscopy units. METHOD: We proposed a score (CDCD score - Cecal intubation, polyp Detection rate, Cleansing and Documentation of cecal intubation) based on the following parameters that assess the quality of colonoscopy units: total colonoscopies rate, polyp detection rate, rate of cecal intubation photo record, rate of recorded Boston bowel preparation scale (BBPS) (rated 1 to 5 stars). The mean score obtained based on the above mentioned criteria was used as a quality parameter of the endoscopy unit...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28242587/impact-of-crossing-strategy-on-mid-term-outcomes-following-percutaneous-revascularisation-of-coronary-chronic-total-occlusions
#16
Lorenzo Azzalini, Rustem Dautov, Emmanouil S Brilakis, Soledad Ojeda, Susanna Benincasa, Barbara Bellini, Aris Karatasakis, Jorge Chavarría, Bavana V Rangan, Manuel Pan, Mauro Carlino, Antonio Colombo, Stéphane Rinfret
AIMS: To compare the impact of crossing strategies on mid-term outcomes following chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS AND RESULTS: We compiled a multicentre registry of consecutive patients undergoing successful CTO PCI. Patients were divided in three groups: true-to-true (TTT) approach, modern dissection/re-entry (DR) techniques (CrossBoss/Stingray, reverse CART), and old DR techniques (LAST, STAR, CART). Cox regression was used to identify independent predictors of major adverse cardiac events (MACE: cardiac death, myocardial infarction and target-vessel revascularisation)...
February 28, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28241180/reevaluating-the-efficacy-and-predictability-of-antidepressant-treatments-a-symptom-clustering-approach
#17
Adam M Chekroud, Ralitza Gueorguieva, Harlan M Krumholz, Madhukar H Trivedi, John H Krystal, Gregory McCarthy
Importance: Depressive severity is typically measured according to total scores on questionnaires that include a diverse range of symptoms despite convincing evidence that depression is not a unitary construct. When evaluated according to aggregate measurements, treatment efficacy is generally modest and differences in efficacy between antidepressant therapies are small. Objectives: To determine the efficacy of antidepressant treatments on empirically defined groups of symptoms and examine the replicability of these groups...
February 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28230451/positive-medication-changes-resulting-from-comprehensive-and-noncomprehensive-medication-reviews-in-a-medicare-part-d-population
#18
Allison Buhl, Jill Augustine, Ann M Taylor, Rose Martin, Terri L Warholak
BACKGROUND: Health care organizations face the challenge of reducing costs while improving health outcomes. Currently, more than 39 million seniors are enrolled in a Medicare Part D prescription benefit plan, many of whom also qualify for medication therapy management (MTM) services. MTM programs provide valuable services designed to prevent or resolve medication-related problems (MRPs). Two core components of all MTM programs include comprehensive medication reviews (CMRs) with followup interventions and focused non-CMR interventions...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28225448/predicting-hcahps-scores-from-hospitals-social-media-pages-a-sentiment-analysis
#19
John W Huppertz, Peter Otto
BACKGROUND: Social media is an important communication channel that can help hospitals and consumers obtain feedback about quality of care. However, despite the potential value of insight from consumers who post comments about hospital care on social media, there has been little empirical research on the relationship between patients' anecdotal feedback and formal measures of patient experience. PURPOSE: The aim of the study was to test the association between informal feedback posted in the Reviews section of hospitals' Facebook pages and scores on two global items from the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, Overall Hospital Rating and Willingness to Recommend the Hospital...
February 22, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28221831/behavioral-hypervolumes-of-predator-groups-and-predator-predator-interactions-shape-prey-survival-rates-and-selection-on-prey-behavior
#20
Jonathan N Pruitt, Kimberly A Howell, Shaniqua J Gladney, Yusan Yang, James L L Lichtenstein, Michelle Elise Spicer, Sebastian A Echeverri, Noa Pinter-Wollman
Predator-prey interactions often vary on the basis of the traits of the individual predators and prey involved. Here we examine whether the multidimensional behavioral diversity of predator groups shapes prey mortality rates and selection on prey behavior. We ran individual sea stars (Pisaster ochraceus) through three behavioral assays to characterize individuals' behavioral phenotype along three axes. We then created groups that varied in the volume of behavioral space that they occupied. We further manipulated the ability of predators to interact with one another physically via the addition of barriers...
March 2017: American Naturalist
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