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Sungheon Gene Kim, Melanie Freed, Ana Paula Klautau Leite, Jin Zhang, Claudia Seuss, Linda Moy
PURPOSE: To assess the diagnostic utility of contrast kinetic analysis for breast lesions and background parenchyma of women undergoing MRI-guided biopsies, for whom standard clinical analysis had failed to separate benign and malignant lesions. MATERIALS AND METHODS: This study included 115 women who had indeterminate lesions based on routine diagnostic breast MRI exams and underwent an MRI (3 Tesla) -guided biopsy of one or more lesions suspicious for breast cancer...
October 20, 2016: Journal of Magnetic Resonance Imaging: JMRI
Joan Montaner, Alejandro Bustamante, Silvia García-Matas, Maite Martínez-Zabaleta, Carmen Jiménez, Javier de la Torre, Francisco R Rubio, Tomás Segura, Jaime Masjuán, David Cánovas, Mar Freijo, Raquel Delgado-Mederos, Javier Tejada, Aida Lago, Yolanda Bravo, Natália Corbeto, Dolors Giralt, Bárbara Vives-Pastor, Anna de Arce, Francisco Moniche, Pilar Delgado, Marc Ribó
BACKGROUND AND PURPOSE: The STARS trial (Stroke Treatment With Acute Reperfusion and Simvastatin) was conducted to demonstrate the efficacy and safety of simvastatin treatment in acute stroke. METHODS: STARS07 was a multicentre, phase IV, prospective, randomized, double-blind, placebo-controlled trial. Patients with Acute ischemic stroke recruited within 12 hours from symptom onset were randomized to oral simvastatin 40 mg or placebo, once daily for 90 days. Primary outcome was proportion of independent patients (modified Rankin Scale score of ≤2) at 90 days...
October 6, 2016: Stroke; a Journal of Cerebral Circulation
M A Sokoto, Rawel Singh, Bhavya B Krishna, Jitendra Kumar, Thallada Bhaskar
Thermal decomposition and kinetics behaviour of the de-oiled seed cake of African star apple (Chrosophyllum albidum) has been investigated using thermogravimetry under the nitrogen atmosphere from ambient temperature to 900 °C. The thermogravimetric data for the cake decomposition at six different heating rates (5, 10, 15, 20, 30 and 40 °C/min) were used to evaluate the kinetic decomposition of the cake using Friedman (FD), Kissinger-Akahira-Sunose (KAS) and Flynn-Wall-Ozawa (FWO) models. Thermal decomposition of the cake showed thermograms indicating dehydration and devolitilization stages (200-400 °C)...
October 2016: Heliyon
C G Bruno, D A Scott, M Aliotta, A Formicola, A Best, A Boeltzig, D Bemmerer, C Broggini, A Caciolli, F Cavanna, G F Ciani, P Corvisiero, T Davinson, R Depalo, A Di Leva, Z Elekes, F Ferraro, Zs Fülöp, G Gervino, A Guglielmetti, C Gustavino, Gy Gyürky, G Imbriani, M Junker, R Menegazzo, V Mossa, F R Pantaleo, D Piatti, P Prati, E Somorjai, O Straniero, F Strieder, T Szücs, M P Takács, D Trezzi
The ^{17}O(p,α)^{14}N reaction plays a key role in various astrophysical scenarios, from asymptotic giant branch stars to classical novae. It affects the synthesis of rare isotopes such as ^{17}O and ^{18}F, which can provide constraints on astrophysical models. A new direct determination of the E_{R}=64.5  keV resonance strength performed at the Laboratory for Underground Nuclear Astrophysics (LUNA) accelerator has led to the most accurate value to date ωγ=10.0±1.4_{stat}±0.7_{syst}  neV, thanks to a significant background reduction underground and generally improved experimental conditions...
September 30, 2016: Physical Review Letters
Michael A Rothfuss, Nicholas G Franconi, Jignesh V Unadkat, Michael L Gimbel, Alexander Star, Marlin H Mickle, Ervin Sejdic
Current totally implantable wireless blood flow monitors are large and cannot operate alongside nearby monitors. To alleviate the problems with the current monitors, we developed a system to monitor blood flow wirelessly, with a simple and easily interpretable real-time output. To the best of our knowledge, the implanted electronics are the smallest in reported literature, which reduces bio-burden. Calibration was performed across realistic physiological flow ranges using a syringe pump. The device's sensors connected directly to the bilateral femoral veins of swine...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Katelyn M Steele, Janelle F Ruisinger, Jessica Bates, Emily S Prohaska, Brittany L Melton, Stephanie Hipp
OBJECTIVE: To evaluate the effects of pharmacist-conducted, home-based comprehensive medication reviews (CMRs) on drug therapy problems (DTPs) in geriatric patients. DESIGN: Pre-/postintervention study. SETTING: Grocery store chain affiliated with three independent living facilities. PARTICIPANTS: Twenty-five older adults using pharmacy delivery services for at least three chronic medications. INTERVENTION: A pharmacist conducted a home-based CMR for each participant...
2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
A Fuente, J Cernicharo, E Roueff, M Gerin, J Pety, N Marcelino, R Bachiller, B Lefloch, O Roncero, A Aguado
CONTEXT: Barnard B1b has revealed as one of the most interesting globules from the chemical and dynamical point of view. It presents a rich molecular chemistry characterized by large abundances of deuterated and complex molecules. Furthermore, it hosts an extremely young Class 0 object and one candidate to First Hydrostatic Core (FHSC) proving the youth of this star forming region. AIMS: Our aim is to determine the cosmic ray ionization rate, [Formula: see text], and the depletion factors in this extremely young star forming region...
September 2016: Astronomy and Astrophysics
Mary C Edgar, Sarah Monsees, Josina Rhebergen, Jennifer Waring, Todd Van der Star, Janice J Eng, Brodie M Sakakibara
: Background/Introduction: Early telerehabilitation trials with stroke survivors have shown promising results, but there remains a lack of knowledge of what areas of rehabilitation people with stroke are interested and willing to receive using technology. The purpose of this study was to describe the access to low-cost consumer technologies and willingness to use them to receive rehabilitation services among stroke survivors. MATERIALS AND METHODS: Participants were included in this survey study if they had a stroke, lived in the community, were 19 years of age or older, and able to understand English...
October 5, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Ye Xu, Mark Reid, Thomas Dame, Karl Menten, Nobuyuki Sakai, Jingjing Li, Andreas Brunthaler, Luca Moscadelli, Bo Zhang, Xingwu Zheng
The nature of the spiral structure of the Milky Way has long been debated. Only in the last decade have astronomers been able to accurately measure distances to a substantial number of high-mass star-forming regions, the classic tracers of spiral structure in galaxies. We report distance measurements at radio wavelengths using the Very Long Baseline Array for eight regions of massive star formation near the Local spiral arm of the Milky Way. Combined with previous measurements, these observations reveal that the Local Arm is larger than previously thought, and both its pitch angle and star formation rate are comparable to those of the Galaxy's major spiral arms, such as Sagittarius and Perseus...
September 2016: Science Advances
J Manik Nava-Sedeño, Adrian Ortiz-Cervantes, Antígona Segura, Shawn D Domagal-Goldman
Lifeless planets with CO2 atmospheres produce CO by CO2 photolysis. On planets around M dwarfs, CO is a long-lived atmospheric compound, as long as UV emission due to the star's chromospheric activity lasts, and the sink of CO and O2 in seawater is small compared to its atmospheric production. Atmospheres containing reduced compounds, like CO, may undergo further energetic and chemical processing to give rise to organic compounds of potential importance for the origin of life. We calculated the yield of organic compounds from CO2-rich atmospheres of planets orbiting M dwarf stars, which were previously simulated by Domagal-Goldman et al...
October 4, 2016: Astrobiology
Hideto Tsuji, Michiaki Ogawa, Yuki Arakawa
Star-shaped four-armed stereo diblock copolymers with an amorphous poly(DL-lactide) (PDLLA) core and a crystalline poly(L-lactide) (PLLA) or poly(D-lactide) (PDLA) shell (4-DL-L and 4-DL-D) and with a crystalline PLLA or PDLA core and amorphous PDLLA shell (4-L-DL and 4-D-DL) copolymers were synthesized. The effects of incorporation and position of amorphous PDLLA blocks on homo- and stereocomplex (SC) crystallization behavior of unblended copolymers and their blends (4-DL-L/4-DL-D and 4-L-DL/4-D-DL) were investigated during isothermal crystallization from the melt and DSC heating...
October 4, 2016: Journal of Physical Chemistry. B
Lisa Henriksen, Kurt M Ribisl, Todd Rogers, Sarah Moreland-Russell, Dianne M Barker, Nikie Sarris Esquivel, Brett Loomis, Erin Crew, Todd Combs
OBJECTIVE: The Standardized Tobacco Assessment for Retail Settings (STARS) was designed to characterise the availability, placement, promotion and price of tobacco products, with items chosen for relevance to regulating the retail tobacco environment. This study describes the process to develop the STARS instrument and protocol employed by a collaboration of US government agencies, US state tobacco control programmes (TCPs), advocacy organisations, public health attorneys and researchers from the National Cancer Institute's State and Community Tobacco Control (SCTC) Research Initiative...
October 2016: Tobacco Control
Sean Shenghsiu Huang, Richard A Hirth
We use the rollout of the five-star rating of nursing homes to study how private-pay prices respond to quality rating. We find that star rating increases the price differential between top- and bottom-ranked facilities. On average, prices of top-ranked facilities increased by 4.8 to 6.0 percent more than the prices of bottom-ranked facilities. We find stronger price effects in markets that are less concentrated where consumers may have more choices of alternative nursing homes. Our results suggest that with simplified design and when markets are less concentrated, consumers are more responsive to quality reporting...
September 3, 2016: Journal of Health Economics
Richard Ellis, Rebecca Blyth, Nick Arnold, Warren Miner-Williams PhD
STUDY DESIGN: Systematic review. INTRODUCTION: It is accepted that the etiology of carpal tunnel syndrome (CTS) is multifactorial. One of the most commonly accepted etiologic factors for CTS is compromise of the kinematic behavior and excursion of the median nerve. PURPOSE OF THE STUDY: The objective of this systematic review was to establish if there is a relationship between impaired median nerve excursion and CTS. METHODS: A systematic review, following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, was conducted...
September 28, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Alison S Attenborough, Peter J Sinclair, Tristan Sharp, Andrew Greene, Max Stuelcken, Richard M Smith, Claire E Hiller
OBJECTIVES: Ankle sprains account for a large percentage of injuries sustained in netball. The identification of risk factors for ankle sprain is the preliminary action required to inform future prevention strategies. DESIGN: Prospective study. PARTICIPANTS: Ninety-four netball players from club and inter-district teams. METHODS: Preseason data were collected for; vertical jump height, perceived ankle instability, sprain history, arthrometry inversion-eversion angles, star excursion balance test reach distances, the number of foot lifts during unilateral stance and demi-pointe balance test results...
June 29, 2016: Physical Therapy in Sport
Eric Carlson, Stefano Profumo, Tim Linden
At present, all physical models of diffuse Galactic γ-ray emission assume that the distribution of cosmic-ray sources traces the observed populations of either OB stars, pulsars, or supernova remnants. However, since H_{2}-rich regions host significant star formation and numerous supernova remnants, the morphology of observed H_{2} gas (as traced by CO line surveys) should also provide a physically motivated, high-resolution tracer for cosmic-ray injection. We assess the impact of utilizing H_{2} as a tracer for cosmic-ray injection on models of diffuse Galactic γ-ray emission...
September 9, 2016: Physical Review Letters
Linda W Xu, Amy Li, Christian Swinney, Maya Babu, Anand Veeravagu, Stacey Quintero Wolfe, Brian V Nahed, John K Ratliff
OBJECTIVE Recently, 2 surgeon rating websites (Consumers' Checkbook and ProPublica) were published to allow the public to compare surgeons through identifying surgeon volume and complication rates. Among neurosurgeons and orthopedic surgeons, only cervical and lumbar spine, hip, and knee procedures were included in this assessment. METHODS The authors examined the methodology of each website to assess potential sources of inaccuracy. Each online tool was queried for reports on neurosurgeons specializing in spine surgery and orthopedic surgeons specializing in spine, hip, or knee surgery...
September 23, 2016: Journal of Neurosurgery. Spine
Tiehong Yang, Wei Li, Xiao Duan, Lin Zhu, Li Fan, Youbei Qiao, Hong Wu
Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. In this work, two types of CPT-conjugated polymers were synthesized based on poly(β-L-malic acid) (PMLA) derivatives. Folic acid (FA) was introduced into the polymers as tumor targeting group. The micellization behaviors of these polymers and antitumor activity of different self-assembled micelles were investigated. Results indicate that poly(ethylene glycol)-poly(β-L-malic acid)-campotothecin-I (PEG-PMLA-CPT-I, P1) is a grafted copolymer, and could form star micelles in aqueous solution with a diameter of about 97 nm, also that PEG-PMLA-CPT-II (P2) is an amphiphilic block copolymer, and could form crew cut micelles with a diameter of about 76 nm...
2016: PloS One
Claus Rödel, Ralf Hofheinz, Emmanouil Fokas
The monolithic approach to apply the same schedule of preoperative 5-fluorouracil (5-FU)- or capecitabine-based chemoradiotherapy (CRT) to all patients with clinically staged TNM stage II/III rectal cancer need to be questioned. Five randomized trials have been completed to determine if the addition of oxaliplatin to preoperative 5-FU/capecitabine-based CRT offers an advantage compared with single-agent CRT. In contrast to the German CAO/ARO/AIO-04 trial, results from the ACCORD 12, STAR-01, PETACC-6 and NSAPB R-04 trials failed to demonstrate a significant improvement of early or late efficacy endpoints with the addition of oxaliplatin...
August 2016: Best Practice & Research. Clinical Gastroenterology
Marcelo M P Tangerina, Hebelin Correa, Brad Haltli, Wagner Vilegas, Russell G Kerr
Shrimp fisheries along the Brazilian coast have significant environmental impact due to high by-catch rates (21 kg per kilogram of shrimp). Typically discarded, by-catch contains many invertebrates that may host a great variety of bacterial genera, some of which may produce bioactive natural products with biotechnological applications. Therefore, to utilize by-catch that is usually discarded we explored the biotechnological potential of culturable bacteria of two abundant by-catch invertebrate species, the snail Olivancillaria urceus and the sea star Luidia senegalensis...
September 19, 2016: Archives of Microbiology
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