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https://www.readbyqxmd.com/read/29348095/estimation-of-simvastatin-and-cetirizine-by-rp-lc-method-application-to-freeze-and-thaw-ft-stability-studies
#1
Safila Naveed, Khan Usmanghani, Aisha Sana, Huma Ali, Farya Zafar, Fatima Qamar, Ghulam Sarwer, Sarah Abbas, M Tanweer Alam, Muhammad Ibrar Shinwari
Sensitive, simple, reliable and rapid HPLC technique for the estimation of simvastatin (SMV) and cetirizine has been designed in this study. The chromatographic conditions were set using Shimadzu LC-10 AT VP pump, with UV detector (SPD-10 AV-VP). System integration was performed with CBM-102 (Bus Module). Partitioning of components was attained with pre-packed C-18 column of Purospher Star (5 μm, 250 x 4.6 mm) at ambient conditions. Injected volume of sample was 10 μl. Mobile phase was composed of 50:50 v/v ratio of Acetonitrile/water (pH 3...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29341709/probing-primordial-black-hole-dark-matter-with-gravitational-waves
#2
Ely D Kovetz
Primordial black holes (PBHs) have long been suggested as a candidate for making up some or all of the dark matter in the Universe. Most of the theoretically possible mass range for PBH dark matter has been ruled out with various null observations of expected signatures of their interaction with standard astrophysical objects. However, current constraints are significantly less robust in the 20  M_{⊙}≲M_{PBH}≲100  M_{⊙} mass window, which has received much attention recently, following the detection of merging black holes with estimated masses of ∼30  M_{⊙} by LIGO and the suggestion that these could be black holes formed in the early Universe...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29337538/sustainable-polyester-elastomers-from-lactones-synthesis-properties-and-enzymatic-hydrolyzability
#3
Guilhem X De Hoe, Michael T Zumstein, Brandon J Tiegs, Jacob P Brutman, Kristopher McNeill, Michael Sander, Geoffrey W Coates, Marc A Hillmyer
Chemically cross-linked elastomers are an important class of polymeric materials with excellent temperature and solvent resistance. However, nearly all elastomers are petroleum-derived and persist in the environment or in landfills long after they are discarded; this work strives to address these issues by demonstrating the synthesis of renewable, enzymatically hydrolyzable, and mechanically competitive polyester elastomers. The elastomers described were synthesized using a novel bis(β-lactone) cross-linker and star-shaped, hydroxyl-terminated poly(γ-methyl-ε-caprolactone)...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29330610/nutrition-delivery-of-a-model-based-icu-glycaemic-control-system
#4
Kent W Stewart, J Geoffrey Chase, Christopher G Pretty, Geoffrey M Shaw
BACKGROUND: Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven difficult. STAR is a proven, effective model-based ICU GC protocol that uniquely maintains normo-glycaemia by changing both insulin and nutrition interventions to maximise nutrition in the context of GC in the 4.4-8.0 mmol/L range. Hence, the level of nutrition it provides is a time-varying estimate of the patient-specific ability to take up glucose...
January 10, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29320508/characterizing-the-field-of-atomic-layer-deposition-authors-topics-and-collaborations
#5
Elsa Alvaro, Angel Yanguas-Gil
This paper describes how Atomic Layer Deposition (ALD) has evolved over time using a combination of bibliometric, social network, and text analysis. We examined the rate of knowledge production as well as changes in authors, journals, and collaborators, showing a steady growth of ALD research. The study of the collaboration network of ALD scientists over time points out that the ALD research community is becoming larger and more interconnected, with a largest connected component that spans 90% of the authors in 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29310638/the-use-of-an-alternate-side-lying-positioning-strategy-during-inhalation-therapy-does-not-prolong-nebulisation-time-in-adults-with-cystic-fibrosis-a-randomised-crossover-trial
#6
Ruth L Dentice, Mark R Elkins, Genevieve M Dwyer, Peter T P Bye
BACKGROUND: Inhalation of nebulised medications is performed in upright sitting to maximise lung volumes. The pattern of deposition is poor for inhaled medications in people with Cystic Fibrosis. The pattern tends to be non-uniform and typically the upper lobes receive a reduced dose compared to the rest of the lung. One strategy that has been proposed as having the potential to improve homogeneity of deposition is to adopt an alternate side lying position for the inhalation procedure...
January 8, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29309588/transmembrane-bax-inhibitor-motif-6-tmbim6-protects-against-cisplatin-induced-testicular-toxicity
#7
Hyun-Kyoung Kim, Raj Kumar Yadav, Kashi Raj Bhattarai, Han-Wool Jung, Hyung-Ryong Kim, Han-Jung Chae
STUDY QUESTION: Is the Transmembrane BAX Inhibitor Motif-6 (TMBIM6) involved in the molecular mechanism by which cisplatin causes reproductive toxicity? SUMMARY ANSWER: TMBIM6 protects against cisplatin-induced testicular toxicity through up-regulation of heme oxygenase-1 (HO-1),-which maintains the levels of steroidogenic enzymes by decreaseing oxidative stress in the endoplasmic reticulum (ER). WHAT IS KNOWN ALREADY: Testosterone production is highly suppressed as a main complication of cisplatin (cis-diamminedichloroplatinum) anticancer therapy...
January 4, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29309223/medicare-advantage-ratings-and-voluntary-disenrollment-among-patients-with-end-stage-renal-disease
#8
Qijuan Li, Amal N Trivedi, Omar Galarraga, Michael E Chernew, Daniel E Weiner, Vincent Mor
Populations with intensive health care needs and high care costs may be attracted to insurance plans that have high quality ratings, but patients may be likely to disenroll from a plan if their care needs are not met. We assessed the association between publicly reported Medicare Advantage plan star ratings and voluntary disenrollment of incident dialysis patients in the following year over the period 2007-13. We found that Medicare Advantage (MA) plans with lower star ratings had significantly higher rates of disenrollment by incident dialysis patients in the following year...
January 2018: Health Affairs
https://www.readbyqxmd.com/read/29309215/medicare-advantage-enrollees-more-likely-to-enter-lower-quality-nursing-homes-compared-to-fee-for-service-enrollees
#9
David J Meyers, Vincent Mor, Momotazur Rahman
Unlike fee-for-service (FFS) Medicare, most Medicare Advantage (MA) plans have a preferred network of care providers that serve most of a plan's enrollees. Little is known about how the quality of care MA enrollees receive differs from that of FFS Medicare enrollees. This article evaluates the differences in the quality of skilled nursing facilities (SNFs) that Medicare Advantage and FFS beneficiaries entered in the period 2012-14. After we controlled for patients' clinical, demographic, and residential neighborhood effects, we found that FFS Medicare patients have substantially higher probabilities of entering higher-quality SNFs (those rated four or five stars by Nursing Home Compare) and those with lower readmission rates, compared to MA enrollees...
January 2018: Health Affairs
https://www.readbyqxmd.com/read/29303956/do-nutrient-based-front-of-pack-labelling-schemes-support-or-undermine-food-based-dietary-guideline-recommendations-lessons-from-the-australian-health-star-rating-system
#10
Mark A Lawrence, Sarah Dickie, Julie L Woods
Food-based Dietary Guidelines (FBDGs) promote healthy dietary patterns. Nutrient-based Front-of-Pack Labelling (NBFOPL) schemes rate the 'healthiness' of individual foods. This study aimed to investigate whether the Australian Health Star Rating (HSR) system aligns with the Australian Dietary Guidelines (ADGs). The Mintel Global New Products Database was searched for every new food product displaying a HSR entering the Australian marketplace from 27 June 2014 (HSR system endorsement) until 30 June 2017. Foods were categorised as either a five food group (FFG) food or 'discretionary' food in accordance with ADG recommendations...
January 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29302009/an-excess-of-massive-stars-in-the-local-30-doradus-starburst
#11
F R N Schneider, H Sana, C J Evans, J M Bestenlehner, N Castro, L Fossati, G Gräfener, N Langer, O H Ramírez-Agudelo, C Sabín-Sanjulián, S Simón-Díaz, F Tramper, P A Crowther, A de Koter, S E de Mink, P L Dufton, M Garcia, M Gieles, V Hénault-Brunet, A Herrero, R G Izzard, V Kalari, D J Lennon, J Maíz Apellániz, N Markova, F Najarro, Ph Podsiadlowski, J Puls, W D Taylor, J Th van Loon, J S Vink, C Norman
The 30 Doradus star-forming region in the Large Magellanic Cloud is a nearby analog of large star-formation events in the distant universe. We determined the recent formation history and the initial mass function (IMF) of massive stars in 30 Doradus on the basis of spectroscopic observations of 247 stars more massive than 15 solar masses ([Formula: see text]). The main episode of massive star formation began about 8 million years (My) ago, and the star-formation rate seems to have declined in the last 1 My...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29300865/crispr-cas9-mediated-tspo-gene-mutations-lead-to-reduced-mitochondrial-membrane-potential-and-steroid-formation-in-ma-10-mouse-tumor-leydig-cells
#12
Jinjiang Fan, Kevin Wang, Barry Zirkin, Vassilios Papadopoulos
The outer mitochondrial membrane translocator protein (TSPO) binds cholesterol with high affinity and is involved in mediating its delivery into mitochondria, the rate-limiting step in hormone-induced steroidogenesis. Specific ligand binding to TSPO has been shown to initiate steroid formation. However, recent studies of the genetic deletion of Tspo have provided conflicting results. Here we address and extend previous studies by examining the effects of Tspo - specific mutations on steroid formation in the hormone- and cAMP-responsive MA-10 cells, using the CRISPR/Cas9 system...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29295490/1950mhz-radio-frequency-electromagnetic-radiation-inhibits-testosterone-secretion-of-mouse-leydig-cells
#13
Yan-Yun Lin, Tao Wu, Jun-Ye Liu, Peng Gao, Kang-Chu Li, Qi-Yan Guo, Meng Yuan, Hai-Yang Lang, Li-Hua Zeng, Guo-Zhen Guo
More studies that are focused on the bioeffects of radio-frequency (RF) electromagnetic radiation that is generated from the communication devices, but there were few reports with confirmed results about the bioeffects of RF radiation on reproductive cells. To explore the effects of 1950 MHz RF electromagnetic radiation (EMR) on mouse Leydig (TM3) cells. TM3 cells were irradiated or sham-irradiated continuously for 24 h by the specific absorption rate (SAR) 3 W/kg radiation. At 0, 1, 2, 3, 4, and 5 days after irradiation, cell proliferation was detected by cell counting kit-8 (CCK-8) method, cell cycle distribution, percentage of apoptosis, and cellular reactive oxygen species (ROS) were examined by flow cytometry, Testosterone level was measured using enzyme-linked immunosorbent assay (ELISA) assay, messenger ribonucleic acid (mRNA) expression level of steroidogenic acute regulatory protein (StAR) and P450scc in TM3 cells was detected by real-time polymerase chain reaction (PCR)...
December 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29294785/-but-he-s-a-star-football-player-how-social-status-influences-mock-jurors-perceptions-in-a-sexual-assault-case
#14
Emily Pica, Chelsea Sheahan, Joanna Pozzulo
There have been several recent, high-profile cases in the media that have shed light on the perceived leniency in sentencing defendants in sexual assault cases. In a number of these cases, the defendant was well known within their community (e.g., Brock Turner; People v. Turner) or nationally (e.g., Ghomeshi; R v. Ghomeshi). The purpose of this study was to examine how the social status of the defendant (low vs. high), victim social status (low vs. high), victim gender (male vs. female), and the reason the victim was unconscious during the assault (consuming alcohol vs...
June 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291597/black-hole-regulated-star-formation-in-massive-galaxies
#15
Ignacio Martín-Navarro, Jean P Brodie, Aaron J Romanowsky, Tomás Ruiz-Lara, Glenn van de Ven
Supermassive black holes, with masses more than a million times that of the Sun, seem to inhabit the centres of all massive galaxies. Cosmologically motivated theories of galaxy formation require feedback from these supermassive black holes to regulate star formation. In the absence of such feedback, state-of-the-art numerical simulations fail to reproduce the number density and properties of massive galaxies in the local Universe. There is, however, no observational evidence of this strongly coupled coevolution between supermassive black holes and star formation, impeding our understanding of baryonic processes within galaxies...
January 1, 2018: Nature
https://www.readbyqxmd.com/read/29284746/atmospheric-escape-from-the-trappist-1-planets-and-implications-for-habitability
#16
Chuanfei Dong, Meng Jin, Manasvi Lingam, Vladimir S Airapetian, Yingjuan Ma, Bart van der Holst
The presence of an atmosphere over sufficiently long timescales is widely perceived as one of the most prominent criteria associated with planetary surface habitability. We address the crucial question of whether the seven Earth-sized planets transiting the recently discovered ultracool dwarf star TRAPPIST-1 are capable of retaining their atmospheres. To this effect, we carry out numerical simulations to characterize the stellar wind of TRAPPIST-1 and the atmospheric ion escape rates for all of the seven planets...
December 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29258543/the-impact-of-interpretive-and-reductive-front-of-pack-labels-on-food-choice-and-willingness-to-pay
#17
Zenobia Talati, Richard Norman, Simone Pettigrew, Bruce Neal, Bridget Kelly, Helen Dixon, Kylie Ball, Caroline Miller, Trevor Shilton
BACKGROUND: This study examined how front-of-pack labels and product healthfulness affect choice and willingness to pay across a range of foods. It was hypothesized that: (i) product choice and (ii) willingness to pay would be more aligned with product healthfulness when healthfulness was expressed through the Health Star Rating, followed by the Multiple Traffic Light, then the Daily Intake Guide, and (iii) the Nutrition Facts Panel would be viewed infrequently. METHODS: Adults and children aged 10+ years (n = 2069) completed an online discrete choice task involving mock food packages...
December 19, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29245860/demonstration-of-the-cdma-mode-caos-smart-camera
#18
Nabeel A Riza, Mohsin A Mazhar
Demonstrated is the code division multiple access (CDMA)-mode coded access optical sensor (CAOS) smart camera suited for bright target scenarios. Deploying a silicon CMOS sensor and a silicon point detector within a digital micro-mirror device (DMD)-based spatially isolating hybrid camera design, this smart imager first engages the DMD starring mode with a controlled factor of 200 high optical attenuation of the scene irradiance to provide a classic unsaturated CMOS sensor-based image for target intelligence gathering...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29236117/liquid-crystal-elastomer-foams-with-elastic-properties-specifically-engineered-as-biodegradable-brain-tissue-scaffolds
#19
M E Prévôt, H Andro, S L M Alexander, S Ustunel, C Zhu, Z Nikolov, S T Rafferty, M T Brannum, B Kinsel, L T J Korley, E J Freeman, J A McDonough, R J Clements, E Hegmann
Tissue regeneration requires 3-dimensional (3D) smart materials as scaffolds to promote transport of nutrients. To mimic mechanical properties of extracellular matrices, biocompatible polymers have been widely studied and a diverse range of 3D scaffolds have been produced. We propose the use of responsive polymeric materials to create dynamic substrates for cell culture, which goes beyond designing only a physical static 3D scaffold. Here, we demonstrated that lactone- and lactide-based star block-copolymers (SBCs), where a liquid crystal (LC) moiety has been attached as a side-group, can be crosslinked to obtain Liquid Crystal Elastomers (LCEs) with a porous architecture using a salt-leaching method to promote cell infiltration...
December 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29236100/reconsidering-hospital-readmission-measures
#20
Peter J Pronovost, Daniel J Brotman, Erik H Hoyer, Amy Deutschendorf
Current hospital readmission measures are part of the Centers for Medicare & Medicaid Services Five-Star Quality Rating System but are inadequate for reporting hospital quality. We review potential biases in the readmission measures and offer policy recommendations to address these biases. Hospital readmission rates are influenced by multiple sources of variation (eg, mix of patients served, bias in the performance measure); true differences in quality of care are often a much smaller source of this variation...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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