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https://www.readbyqxmd.com/read/28646768/source-profiling-of-arsenic-and-heavy-metals-in-the-selangor-river-basin-and-their-maternal-and-cord-blood-levels-in-selangor-state-malaysia
#1
Nobumitsu Sakai, Zohour Alsaad, Nguyen Thi Thuong, Kenji Shiota, Minoru Yoneda, Mustafa Ali Mohd
Arsenic and 5 heavy metals (nickel, copper, zinc, cadmium and lead) were quantitated in surface water (n = 18) and soil/ore samples (n = 45) collected from 5 land uses (oil palm converted from forest, oil palm in peat swamp, bare land, quarry and forest) in the Selangor River basin by inductively coupled plasma mass spectrometry (ICP-MS). Geographic information system (GIS) was used as a spatial analytical tool to classify 4 land uses (forest, agriculture/peat, urban and bare land) from a satellite image taken by Landsat 8...
June 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28646756/protein-functionalization-of-zno-nanostructure-exhibits-selective-and-enhanced-toxicity-to-breast-cancer-cells-through-oxidative-stress-based-cell-death-mechanism
#2
Sailendra Mahanta, S Prathap, Deependra Kumar Ban, Subhankar Paul
Zinc oxide nanostructure (ZnONS) was chemically synthesized and functionalized (FZnONSBLA) with a small protein bovine α-lactalbumin (BLA) by chemical cross-linking methods. Both nano-structures were characterized using various techniques such as electron microscopy, dynamic light scattering (DLS), UV-Vis spectroscopy, FT-IR, photo-luminescence and X-ray diffraction. Electron microscopy and DLS analysis revealed their (ZnONS and FZnONSBLA) average size of 200nm and 450nm, respectively. When cytotoxicity of both the nanostructures were assessed in breast cancer cells MCF-7 and MDAMB231 by MTT assay and PI/Annexin V staining (FACS), FZnONSBLA demonstrated higher cell death than ZnONS primarily due to generation of intracellular reactive oxygen species (ROS)...
June 15, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28646748/the-influence-of-iron-oxide-nanoparticles-upon-the-adsorption-of-organic-matter-on-magnetic-powdered-activated-carbon
#3
Kim Maren Lompe, David Menard, Benoit Barbeau
Combining powdered activated carbon (PAC) with magnetic iron oxides has been proposed in the past to produce adsorbents for natural organic matter (NOM) removal that can be easily separated using a magnetic field. However, the trade-off between the iron oxides' benefits and the reduced carbon content, porosity, and surface area has not yet been investigated systematically. We produced 3 magnetic powdered activated carbons (MPAC) with mass fractions of 10%, 38% and 54% maghemite nanoparticles and compared them to bare PAC and pure nanoparticles with respect to NOM adsorption kinetics and isotherms...
June 17, 2017: Water Research
https://www.readbyqxmd.com/read/28646572/general-fate-model-for-microconstituents-in-an-activated-sludge-system
#4
Bahman Banihashemi
Nine lab-scale continuous flow porous-pot bioreactors operating at various solids retention times and hydraulic retention times were conducted to simulate activated sludge (AS) systems and to evaluate the biodegradation kinetic models for the fate of 17α-ethinylestradiol (EE2), bisphenol-A (BPA), and triclosan (TCS) at the µg/L range. Mathematical models were applied to describe the degradation mechanism of selected microconstituents (MCs) and pseudo second-order model were found to best fit the results when active MCs degraders (XC) were used (r2= 0...
June 16, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28646521/enhancing-perovskite-electrocatalysis-of-solid-oxide-cells-through-controlled-growth-of-nanoparticles
#5
Bin Hua, Meng Li, Yi-Fei Sun, Jian-Hui Li, Jing-Li Luo
Perovskite oxides have received a great deal of attentions as promising electrodes in both solid oxide fuel cells (SOFCs) and solid oxide electrolyzer cells (SOECs) because of their reasonable reactivity, impurity tolerance, tunable property, etc. Particular explorations are still required for advancing the perovskite electrodes, which normally suffer from slow kinetics in electrocatalysis. In the past decades, several experimental studies have developed new classes of perovskites with advanced characteristics and electrode kinetics at technical levels...
June 24, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28646435/eco-friendly-synthesis-of-silver-nanoparticles-using-green-algae-caulerpa-serrulata-reaction-optimization-catalytic-and-antibacterial-activities
#6
Eman F Aboelfetoh, Rania A El-Shenody, Mohamed M Ghobara
Stable colloidal silver nanoparticles (AgNPs) were synthesized using Caulerpa serrulata (green marine algae) aqueous extract as an efficient reducing and stabilizing agent. This method is considered to be a sustainable alternate to the more complicated chemical procedures. To achieve the optimization synthesis of AgNPs, several effects such as extract concentration, contact time, pH values, and temperature were examined. The synthesized AgNPs were characterized by UV-Vis spectroscopy, FT-IR, XRD, and HR-TEM...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28646425/hydroxylamine-induced-oxidation-of-ferrous-carbonylated-truncated-hemoglobins-from-mycobacterium-tuberculosis-and-campylobacter-jejuni-is-limited-by-carbon-monoxide-dissociation
#7
Paolo Ascenzi, Chiara Ciaccio, Tecla Gasperi, Alessandra Pesce, Lucia Caporaso, Massimo Coletta
Hydroxylamine (HA) is an oxidant of ferrous globins and its action has been reported to be inhibited by CO, even though this mechanism has not been clarified. Here, kinetics of the HA-mediated oxidation of ferrous carbonylated Mycobacterium tuberculosis truncated hemoglobin N and O (Mt-trHbN(II)-CO and Mt-trHbO(II)-CO, respectively) and Campylobacter jejuni truncated hemoglobin P (Cj-trHbP(II)-CO), at pH 7.2 and 20.0 °C, are reported. Mixing Mt-trHbN(II)-CO, Mt-trHbO(II)-CO, and Cj-trHbP(II)-CO solution with the HA solution brings about absorption spectral changes reflecting the disappearance of the ferrous carbonylated derivatives with the concomitant formation of the ferric species...
June 23, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28646323/erratum-to-quantitative-18f-fluorocholine-positron-emission-tomography-for-prostate-cancer-correlation-between-kinetic-parameters-and-gleason-scoring
#8
Joshua D Schaefferkoetter, Ziting Wang, Mary C Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W Townsend, Thomas Thamboo, Edmund Chiong
No abstract text is available yet for this article.
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28646247/sucrose-octaacetate-chemical-kinetics-and-shelf-lives-at-various-formulation-phs
#9
Shalini Gaddam, William C Stagner
Developing pediatric friendly dosage forms is a high priority worldwide. Sucrose octaacetate (SOA) has been recommended for use as a surrogate for bitter tasting active pharmaceutical ingredients. Even though SOA has found a number of human use applications and has been employed for decades, there are no rigorous chemical kinetic studies reported. A recently reported SOA stability-indicating method was used to perform SOA chemical kinetic and stability studies. As part of the chemical kinetic study, reaction order, activation energies, extrapolated rate constants, pH-rate profiles at 4 and 25°C, and estimated shelf lives at 4 and 25°C at different buffer pHs are provided...
June 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28646234/electroporation-as-a-vaccine-delivery-system-and-a-natural-adjuvant-to-intradermal-administration-of-plasmid-dna-in-macaques
#10
Biliana Todorova, Lucille Adam, Slobodan Culina, Raphaël Boisgard, Frédéric Martinon, Antonio Cosma, Mart Ustav, Thierry Kortulewski, Roger Le Grand, Catherine Chapon
In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association with DNA vaccination greatly stimulates immune responses to vaccine antigens delivered through the skin. However, the effect of EP on cutaneous cell behavior, the dynamics of immune cell recruitment and local inflammatory factors, have not been fully described. Here, we show that intradermal DNA vaccination combined with EP extends antigen expression to the epidermis and the subcutaneous skin muscle in non-human primates...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646180/sustained-release-from-a-metal-analgesics-entrapped-within-biocidal-silver
#11
Barak Menagen, Rami Pedahzur, David Avnir
Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646094/immune-mediated-effects-targeting-hepatitis-c-virus-in-a-syngeneic-replicon-cell-transplantation-mouse-model
#12
Sepideh Levander, Fredrik Holmström, Lars Frelin, Gustaf Ahlén, Daniel Rupp, Gang Long, Ralf Bartenschlager, Matti Sällberg
OBJECTIVE: HCV is characterised by its ability to establish chronic infection in hepatocytes and to replicate in the presence of an inflammation. We mimicked this situation in vivo in immune-competent mice by syngeneic transplantation of HCV replicon-containing mouse hepatoma cells. DESIGN: A total of 5 million H-2(b) positive Hep56.1D cells, carrying a subgenomic genotype (gt) 2a replicon (HCV replicon cells) or stably expressing comparable levels of the HCV NS3/4A protease/helicase complex (NS3/4A hepatoma cells), were injected subcutaneously into syngeneic H-2(b)-restricted mice...
June 23, 2017: Gut
https://www.readbyqxmd.com/read/28646078/stereospecific-metabolism-of-r-and-s-warfarin-by-human-hepatic-cytosolic-reductases
#13
Dustyn A Barnette, Bryce Johnson, Dakota L Pouncey, Robert Nshimiyimana, Linda Desrochers, Thomas E Goodwin, Grover Paul Miller
Coumadin (rac-warfarin) is the most commonly used anticoagulant in the world, yet its clinical use is often challenging due to a narrow therapeutic range and inter-individual variations in response. A critical contributor to the uncertainty is variability in warfarin metabolism, which includes mostly oxidative but also reductive pathways. Reduction of each warfarin enantiomer yields two warfarin alcohol isomers, and the corresponding four alcohols retain varying levels of anticoagulant activity. Studies on the kinetics of warfarin reduction have often lacked resolution of parent drug enantiomers and suffered from co-elution of pairs of alcohol metabolites; thus, those studies fail to establish the importance of individual, stereospecific reductive pathways...
June 23, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28645833/binding-kinetics-and-pathways-of-ligands-to-gpcrs
#14
REVIEW
Andrea Strasser, Hans-Joachim Wittmann, Roland Seifert
Previously, drugs were developed focusing on target affinity and selectivity. However, it is becoming evident that the drug-target residence time, related to the off-rate, is an important parameter for successful drug development. The residence time influences both the on-rate and overall effectiveness of drugs. Furthermore, ligand binding is now appreciated to be a multistep process because metastable and/or intermediate binding sites in the extracellular region have been identified. In this review, we summarize experimental ligand-binding data for G-protein-coupled receptors (GPCRs), and their binding pathways, analyzed by molecular dynamics (MD)...
June 20, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28645809/enhanced-in-vivo-retention-of-low-dose-bmp-2-via-heparin-microparticle-delivery-does-not-accelerate-bone-healing-in-a-critically-sized-femoral-defect
#15
Marian H Hettiaratchi, Tel Rouse, Catherine Chou, Laxminarayanan Krishnan, Hazel Y Stevens, Mon-Tzu A Li, Todd C McDevitt, Robert E Guldberg
Bone morphogenetic protein-2 (BMP-2) is an osteoinductive growth factor used clinically to induce bone regeneration and fusion. Some complications associated with BMP-2 treatment have been attributed to rapid release of BMP-2 from conventional collagen scaffolds, motivating the development of tunable sustained-release strategies. We incorporated BMP-2-binding heparin microparticles (HMPs) into a hydrogel scaffold to improve spatiotemporal control of BMP-2 delivery to large bone defects. HMPs pre-loaded with BMP-2 were mixed into alginate hydrogels and compared to hydrogels containing BMP-2 alone...
June 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28645735/serum-amyloid-a-self-assembles-with-phospholipids-to-form-stable-protein-rich-nanoparticles-with-a-distinct-structure-a-hypothetical-function-of-saa-as-a-molecular-mop-in-immune-response
#16
Nicholas M Frame, Shobini Jayaraman, Donald L Gantz, Olga Gursky
Serum amyloid A (SAA) is an acute-phase protein whose action in innate immunity and lipid homeostasis is unclear. Most circulating SAA binds plasma high-density lipoproteins (HDL) and reroutes lipid transport. In vivo SAA binds existing lipoproteins or generates them de novo upon lipid uptake from cells. We explored the products of SAA-lipid interactions and lipoprotein remodeling in vitro. SAA complexes with palmitoyl-oleoyl phosphocholine (POPC) were analyzed for structure and stability using circular dichroism and fluorescence spectroscopy, electron microscopy, gel electrophoresis and gel filtration...
June 20, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28645713/propranolol-kinetics-in-plasma-from-severely-burned-adults
#17
Ashley N Guillory, David N Herndon, Michael B Silva, Clark R Andersen, Erge Edgu-Fry, Oscar E Suman, Celeste C Finnerty
OBJECTIVES: The aim of this study was to determine the appropriate propranolol dosing strategy for reducing heart rate in severely burned adults. METHODS: A total of 26 patients (≥18 years) with burns covering ≥30% of the total body surface area were included in this IRB-approved study. Plasma propranolol concentrations were determined in a placebo group (n=10) or following one of three dosing strategies: Q6 (n=4), Q8 (n=6), and Q24 (n=6). Blood was collected just before dosing and at regular intervals over two dosing periods with corresponding heart rate and blood pressure recordings...
June 20, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28645580/chemostat-studies-of-bacteriophage-m13-infected-escherichia-coli-jm109-for-continuous-ssdna-production
#18
Benjamin Kick, Karl Lorenz Behler, Timm Steffen Severin, Dirk Weuster-Botz
Steady state studies in a chemostat enable the control of microbial growth rate at defined reaction conditions. The effects of bacteriophage M13 infection on maximum growth rate of Escherichia coli JM109 were studied in parallel operated chemostats on a milliliter-scale to analyze the steady state kinetics of phage production. The bacteriophage infection led to a decrease in maximum specific growth rate of 15 % from 0.74 h(-1) to 0.63 h(-1). Under steady state conditions, a constant cell specific ssDNA formation rate of 0...
June 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28645455/kinematic-chain-reactions-on-trunk-and-dynamic-postural-steadiness-in-subjects-with-recurrent-low-back-pain
#19
Paul S Sung, Michael J Maxwell
Although subjects with recurrent low back pain (LBP) demonstrate altered trunk control, the kinematic and kinetic responses of the trunk have not been carefully investigated. This study was conducted to compare the standing time, spine range of motion (ROM), and dynamic postural steadiness index (DPSI) based on visual condition between subjects with and without recurrent LBP during upright one leg standing. Sixty-three individuals participated in the study, including 34 control subjects and 29 subjects with recurrent LBP...
June 8, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28645169/heterodimerization-of-arabidopsis-calcium-proton-exchangers-contributes-to-regulation-of-guard-cell-dynamics-and-plant-defense-responses
#20
Bradleigh Hocking, Simon J Conn, Murli Manohar, Bo Xu, Asmini Athman, Matthew A Stancombe, Alex R Webb, Kendal D Hirschi, Matthew Gilliham
Arabidopsis thaliana cation exchangers (CAX1 and CAX3) are closely related tonoplast-localized calcium/proton (Ca2+/H+) antiporters that contribute to cellular Ca2+ homeostasis. CAX1 and CAX3 were previously shown to interact in yeast; however, the function of this complex in plants has remained elusive. Here, we demonstrate that expression of CAX1 and CAX3 occurs in guard cells. Additionally, CAX1 and CAX3 are co-expressed in mesophyll tissue in response to wounding or flg22 treatment, due to the induction of CAX3 expression...
June 22, 2017: Journal of Experimental Botany
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