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https://www.readbyqxmd.com/read/29353377/highly-synergistic-activity-of-melittin-with-imipenem-and-colistin-in-biofilm-inhibition-against-multidrug-resistant-strong-biofilm-producer-strains-of-acinetobacter-baumannii
#1
Ali Mohammadi Bardbari, Mohammad Reza Arabestani, Manoochehr Karami, Fariba Keramat, Hossein Aghazadeh, Mohammad Yousef Alikhani, Kamran Pooshang Bagheri
The rapid increase of drug resistance and failure of available antibiotics to treat biofilm-associated infections is of great health concern. Accordingly, our study aimed to evaluate the synergistic antibacterial, biofilm inhibitory, and biofilm removal activities of melittin in combination with colistin, imipenem, and ciprofloxacin against multidrug-resistant (MDR) strong biofilm producer Acinetobacter baumannii isolates. The kinetics of biofilm formation were evaluated for the isolates for 144 h. Minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), minimum biofilm inhibitory concentrations (MBICs), and biofilm removal activities for melittin and combinations with antibiotics were determined...
January 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29353350/clinical-pharmacokinetics-and-pharmacodynamics-of-evolocumab-a-pcsk9-inhibitor
#2
REVIEW
Sreeneeranj Kasichayanula, Anita Grover, Maurice G Emery, Megan A Gibbs, Ransi Somaratne, Scott M Wasserman, John P Gibbs
Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein cholesterol (LDL-C) by decreasing expression of the LDL receptor on hepatic cells. Evolocumab is a human monoclonal immunoglobulin G2 that binds specifically to human PCSK9 to reduce LDL-C. Evolocumab exhibits nonlinear kinetics as a result of binding to PCSK9. Elimination is predominantly through saturable binding to PCSK9 at lower concentrations and a nonsaturable proteolytic pathway at higher concentrations. The effective half-life of evolocumab is 11-17 days...
January 20, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29353308/single-stage-autotrophic-nitrogen-removal-process-at-high-loading-rate-granular-reactor-performance-kinetics-and-microbial-characterization
#3
Feiyue Qian, Abebe Temesgen Gebreyesus, Jianfang Wang, Yaoliang Shen, Wenru Liu, Lulin Xie
For the possible highest performance of single-stage combined partial nitritation/anammox (PNA) process, a continuous complete-mix granular reactor was operated at progressively higher nitrogen loading rate. The variations in bacterial community structure of granules were also characterized using high-throughput pyrosequencing, to give a detail insight to the relationship between reactor performance and functional organism abundance within completely autotrophic nitrogen removal system. In 172 days of operation, a superior total nitrogen (TN) removal rate over 3...
January 20, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29353196/high-adsorption-of-methylene-blue-by-salicylic-acid-methanol-modified-steel-converter-slag-and-evaluation-of-its-mechanism
#4
Min Cheng, Guangming Zeng, Danlian Huang, Cui Lai, Yang Liu, Chen Zhang, Rongzhong Wang, Lei Qin, Wenjing Xue, Biao Song, Shujing Ye, Huan Yi
A novel adsorbent based on steel converter slag (SCS), useful for adsorbing cationic pollutants from water was prepared by a simple method. The characterization showed that salicylic acid-methanol (SAM) modification selectively removed calcium silicate minerals from the surface of SCS and lead to a prominent increase in the specific surface areas. The maximum adsorption capacity of SAM-modified SCS for methylene blue (MB) at initial pH of 7.0 and temperature of 293 K was 41.62 mg/g, which is 35.2-times higher than that of SCS (1...
January 3, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29353191/kinetic-and-equilibrium-modelling-of-mtbe-methyl-tert-butyl-ether-adsorption-on-zsm-5-zeolite-batch-and-column-studies
#5
Yunhui Zhang, Fei Jin, Zhengtao Shen, Rod Lynch, Abir Al-Tabbaa
The intensive use of methyl tert-butyl ether (MTBE) as a gasoline additive has resulted in serious environmental problems due to its high solubility, volatility and recalcitrance. The feasibility of permeable reactive barriers (PRBs) with ZSM-5 type zeolite as a reactive medium was explored for MTBE contaminated groundwater remediation. Batch adsorption studies showed that the MTBE adsorption onto ZSM-5 follows the Langmuir model and obeys the pseudo-second-order model with an adsorption capacity of 53.55 mg g-1...
January 10, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29353188/mechanism-of-anaerobic-bio-reduction-of-azo-dye-assisted-with-lawsone-immobilized-activated-carbon
#6
Daniel Olivo-Alanis, Refugio Bernardo Garcia-Reyes, Luis H Alvarez, Alcione Garcia-Gonzalez
Lawsone redox (LQ) mediator was covalently bound to granular activated carbon (GAC) by Fischer esterification. A high LQ adsorption capacity on GAC was achieved (∼230 mg/g), and desorption studies showed strong chemical stability. Furthermore, kinetic experiments with solid-phase redox mediator (RM) and their controls (soluble RM, GAC and anaerobic sludge) were tested for decolorization of congo red dye at initial concentration of 175 mg/L. Benzidine, a by-product of complete congo red reduction, was also measured by HPLC analysis along the kinetic experiments...
January 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29353115/efficient-removal-of-acid-green-25-dye-from-wastewater-using-activated-prunus-dulcis-as-biosorbent-batch-and-column-studies
#7
Suyog N Jain, Parag R Gogate
Biosorbent synthesized from dead leaves of Prunus Dulcis with chemical activation during the synthesis was applied for the removal of Acid Green 25 dye from wastewater. The obtained biosorbent was characterized using Brunauer-Emmett-Teller analysis, Fourier transform-infrared spectroscopy and scanning electron microscopy measurements. It was demonstrated that alkali treatment during the synthesis significantly increased surface area of biosorbent from 67.205 to 426.346 m2/g. The effect of various operating parameters on dye removal was investigated in batch operation and optimum values of parameters were established as pH of 2, 14 g/L as the dose of natural biosorbent and 6 g/L as the dose of alkali treated biosorbent...
January 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29353083/combining-ultrasound-and-intratumoral-administration-of-doxorubicin-loaded-microspheres-to-enhance-tumor-cell-killing
#8
Anh-Vu Do, Sean M Geary, Dongrim Seol, Phillip Tobias, Daniel Carlsen, Nattawut Leelakanok, James A Martin, Aliasger K Salem
Melanoma is an incurable disease for which alternative treatments to chemotherapy alone are sought. Here, using a melanoma model, we investigated the antitumor potential of combining ultrasound (US) with poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with doxorubicin (DOX). The aim was to achieve synergistic tumoricidal activity through direct and indirect US-mediated damage of tumor cells combined with sustained and potentially controllable release (when combined with US) of DOX from microspheres...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29353070/7-hydroxylation-of-warfarin-is-strongly-inhibited-by-sesamin-but-not-by-episesamin-caffeic-and-ferulic-acids-in-human-hepatic-microsomes
#9
Nadezhda Pilipenko, Martin Krøyer Rasmussen, Olena Doran, Galia Zamaratskaia
Warfarin is a commonly used anticoagulant drug and is a derivate of coumarin. Cytochrome P450 2C9 (CYP2C9) plays the key role in transformation of coumarin and thus, influences determination of warfarin dosage. A number of factors including dietary compounds such as sesamin, caffeic acid and ferulic acids can regulate the activity of CYP2C9. The present study tested the hypothesis that sesamin, episesamin, caffeic acid and ferulic acid decreases the rate of warfarin 7-hydroxylation via inhibition of hepatic CYP2C9...
January 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29352925/influence-of-hydrothermal-treatment-on-the-structural-modification-of-spent-grain-specific-carbohydrates-and-the-formation-of-degradation-products-using-model-compounds
#10
J Steiner, K Franke, M Kießling, S Fischer, S Töpfl, V Heinz, T Becker
Brewer's spent grain (BSG) constitutes various valuable carbohydrates that may contribute to a healthy diet. These components may be obtained from BSG via hydrothermal treatment (HT), a procedure for dissolving water-inextricable carbohydrates. The objective of this study was to investigate HT as an environmentally friendly technology for extracting high-molecular-weight fiber with proven beneficial effects on human health. Cellulose, β-glucan, and arabinoxylan (AX) served as model substances and were subjected to auto-hydrolysis at different temperatures and reaction times...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352920/biomass-based-magnetic-fluorescent-nanoparticles-one-step-scalable-synthesis-application-as-drug-carriers-and-mechanism-study
#11
Lei Li, Feijun Wang, Ziqiang Shao
A biomass-based magnetic fluorescent nanoparticle (MFNPs) was successively in situ synthesized via a one-step high-gravity approach, which constructed by a magnetic core of Fe3O4 nanoparticles, the fluorescent marker of carbon dots (CDs), and shells of chitosan (CS). The obtained MFNPs had a 10 nm average diameter and narrow particle size distribution, low cytotoxicity, superior fluorescent emission and superparamagnetic properties. The encapsulating and release 5-fluorouracil experiments confirmed that the introduction of CS/CDs effectively improved the drug loading capacity...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352886/aldehyde-functionalized-chitosan-montmorillonite-films-as-dynamically-assembled-switchable-chemical-release-bioplastics
#12
Jamal Chabbi, Oumayma Jennah, Nadia Katir, Mohamed Lahcini, Mosto Bousmina, Abdelkrim El Kadib
Temporal release of synergistic and/or complementary chemicals (e.g.: drugs) is recognized as extremely challenging because of their frequently intertwined kinetic delivery and presently, straightforward concepts enabling to circumvent this bottleneck are missing in the open literature. In this framework, we report herein on aldehyde-functionalized, transparent and flexible chitosan-montmorillonite hybrid films that act as a new generation of eco-friendly, controlled-chemical release bioplastics. These dynamically-assembled nanomaterials are designed by a ternary assembly from biowaste derived chitin biopolymer, aromatic aldehydes and layered clay nanoparticles...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352883/the-use-of-starch-azure-for-measurement-of-alpha-amylase-activity
#13
Gábor Lehoczki, Lili Kandra, Gyöngyi Gyémánt
Despite being widely used, there is no standard protocol for α-amylase activity measurement with starch azure substrate. Boiling pre-treatment of starch azure suspension increased the reaction rate of hydrolysis catalysed by human salivary α-amylase (HSA) or porcine pancreatic α-amylase (PPA) and the sensitivity of spectrophotometric activity measurement has been improved. Kinetic constants, KM, and vmax, obtained from parallel isothermal titration calorimetric (ITC) measurements on natural and starch azure revealed, that the blue starch derivative does not differ significantly from its natural counterpart from kinetic point of view...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352870/radiation-grafting-a-voyage-from-bio-waste-corn-husk-to-an-efficient-thermostable-adsorbent
#14
Jhimli Paul Guin, Y K Bhardwaj, Lalit Varshney
The initiator free environmentally benign gamma radiation is employed to graft poly-acrylic acid (PAA) onto the widely produced bio-waste corn husk to develop promising, cheap, efficient and reusable adsorbent (AAc-g-husk) having specific adsorption capacity of 1682.7mgg-1 of methylene blue (MB) at pH 9.0 and 320K. The most suitable grafting yield is found by optimizing absorbed dose, dose rate and concentrations of monomer, Mohr's salt and inorganic acid. The inter-planar hydrogen bonding among (002) planes of cellulose in the husk decreases after diversifying grafting of PAA on ad-axial, ribs and micro-fibrils surfaces of the corn husks...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352783/addressing-global-uncertainty-and-sensitivity-in-first-principles-based-microkinetic-models-by-an-adaptive-sparse-grid-approach
#15
Sandra Döpking, Craig P Plaisance, Daniel Strobusch, Karsten Reuter, Christoph Scheurer, Sebastian Matera
In the last decade, first-principles-based microkinetic modeling has been developed into an important tool for a mechanistic understanding of heterogeneous catalysis. A commonly known, but hitherto barely analyzed issue in this kind of modeling is the presence of sizable errors from the use of approximate Density Functional Theory (DFT). We here address the propagation of these errors to the catalytic turnover frequency (TOF) by global sensitivity and uncertainty analysis. Both analyses require the numerical quadrature of high-dimensional integrals...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352780/hydrogen-collisions-with-transition-metal-surfaces-universal-electronically-nonadiabatic-adsorption
#16
Yvonne Dorenkamp, Hongyan Jiang, Hansjochen Köckert, Nils Hertl, Marvin Kammler, Svenja M Janke, Alexander Kandratsenka, Alec M Wodtke, Oliver Bünermann
Inelastic scattering of H and D atoms from the (111) surfaces of six fcc transition metals (Au, Pt, Ag, Pd, Cu, and Ni) was investigated, and in each case, excitation of electron-hole pairs dominates the inelasticity. The results are very similar for all six metals. Differences in the average kinetic energy losses between metals can mainly be attributed to different efficiencies in the coupling to phonons due to the different masses of the metal atoms. The experimental observations can be reproduced by molecular dynamics simulations based on full-dimensional potential energy surfaces and including electronic excitations by using electronic friction in the local density friction approximation...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352283/using-a-model-comparison-approach-to-describe-the-assembly-pathway-for-histone-h1
#17
Carlos Contreras, Minaya Villasana, Michael J Hendzel, Gustavo Carrero
Histones H1 or linker histones are highly dynamic proteins that diffuse throughout the cell nucleus and associate with chromatin (DNA and associated proteins). This binding interaction of histone H1 with the chromatin is thought to regulate chromatin organization and DNA accessibility to transcription factors and has been proven to involve a kinetic process characterized by a population that associates weakly with chromatin and rapidly dissociates and another population that resides at a binding site for up to several minutes before dissociating...
2018: PloS One
https://www.readbyqxmd.com/read/29352253/tracking-the-evolution-of-transiently-transfected-individual-cells-in-a-microfluidic-platform
#18
Micaela Tamara Vitor, Sébastien Sart, Antoine Barizien, Lucimara Gaziola De La Torre, Charles N Baroud
Transient gene expression (TGE) technology enables the rapid production of large amount of recombinant proteins, without the need of fastidious screening of the producing cells required for stable transfection (ST). However, several barriers must be overcome before reaching the production yields using ST. For optimizing the production yields from suspended cells using TGE, a better understanding of the transfection conditions at the single cell level are required. In this study, a universal droplet microfluidic platform was used to assess the heterogeneities of CHO-S population transiently transfected with cationic liposomes (CL) (lipoplexes) complexed with GFP-coding plasmid DNA (pDNA)...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352217/bedside-assessment-of-regional-cerebral-perfusion-using-near-infrared-spectroscopy-and-indocyanine-green-in-patients-with-atherosclerotic-occlusive-disease
#19
Hiroshi Saito, Tatsuya Ishikawa, Jun Tanabe, Shinya Kobayashi, Junta Moroi
This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with 15O-labeled gas...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352184/expression-and-relevance-of-the-g-protein-gated-k-channel-in-the-mouse-ventricle
#20
Allison Anderson, Kanchan Kulkarni, Ezequiel Marron Fernandez de Velasco, Nicholas Carlblom, Zhilian Xia, Atsushi Nakano, Kirill A Martemyanov, Elena G Tolkacheva, Kevin Wickman
The atrial G protein-gated inwardly rectifying K+ (GIRK) channel is a critical mediator of parasympathetic influence on cardiac physiology. Here, we probed the details and relevance of the GIRK channel in mouse ventricle. mRNAs for the atrial GIRK channel subunits (GIRK1, GIRK4), M2 muscarinic receptor (M2R), and RGS6, a negative regulator of atrial GIRK-dependent signaling, were detected in mouse ventricle at relatively low levels. The cholinergic agonist carbachol (CCh) activated small GIRK currents in adult wild-type ventricular myocytes that exhibited relatively slow kinetics and low CCh sensitivity; these currents were absent in ventricular myocytes from Girk1-/- or Girk4-/- mice...
January 19, 2018: Scientific Reports
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