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https://www.readbyqxmd.com/read/28964114/fast-slow-asymptotics-for-a-markov-chain-model-of-fast-sodium-current
#1
Tomáš Starý, Vadim N Biktashev
We explore the feasibility of using fast-slow asymptotics to eliminate the computational stiffness of discrete-state, continuous-time deterministic Markov chain models of ionic channels underlying cardiac excitability. We focus on a Markov chain model of fast sodium current, and investigate its asymptotic behaviour with respect to small parameters identified in different ways.
September 2017: Chaos
https://www.readbyqxmd.com/read/28866212/growth-of-a-tinb-adhesion-interlayer-for-bioactive-coatings
#2
Zdeněk Tolde, Vladimír Starý, Ladislav Cvrček, Marta Vandrovcová, Jan Remsa, Stanislav Daniš, Jan Krčil, Lucie Bačáková, Petr Špatenka
Surface bioactivity has been under intensive study with reference to its use in medical implants. Our study is focused on coatings prepared from an electroactive material which can support bone cell adhesion. Until now, hydroxyapatite films have usually been utilized as a chemically-active surface agent. However, electrically-active films could set a new direction in hard tissue replacement. As a base for these films, it is necessary to prepare an intermediate film, which can serve as a suitable barrier against the possible diffusion of some allergens and toxic elements from the substrate...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28853493/staphylococcal-scalded-skin-syndrome-caused-by-a-rare-variant-of-exfoliative-toxin-a-s-aureus-in-an-adult-immunocompromised-woman
#3
Simona Saluzzo, Franziska Layer, Georg Stingl, Georg Stary
No abstract text is available yet for this article.
August 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28852391/serum-prealbumin-as-an-effective-prognostic-indicator-for-determining-clinical-status-and-prognosis-in-patients-with-hemorrhagic-stroke
#4
Shen-Qi Zhang, Bin Peng, Creed M Stary, Zhi-Hong Jian, Xiao-Xing Xiong, Qian-Xue Chen
Serum prealbumin is a recognized marker of malnutrition, but its prognostic role in patients with hemorrhagic stroke remains unclear. In this study, we retrospectively reviewed the records of 105 patients with hemorrhagic stroke admitted to Renmin Hospital of Wuhan University, China, from January to December 2015. We collected demographic and radiological data, and recorded serum prealbumin levels at admission and on days 1, 3, 6, 9, and 14-21. The existence of infections and gastrointestinal hemorrhage, and clinical condition at discharge were also recorded...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28842488/conserved-functional-consequences-of-disease-associated-mutations-in-the-slide-helix-of-kir6-1-and-kir6-2-subunits-of-the-atp-sensitive-potassium-channel
#5
Paige E Cooper, Conor McClenaghan, Xingyu Chen, Anna Stary-Weinzinger, Colin G Nichols
Cantu syndrome (CS) is a condition characterized by a range of anatomical defects, including cardiomegaly, hyper-flexibility of the joints, hypertrichosis, and craniofacial dysmorphology. CS is associated with multiple missense mutations in the genes encoding the regulatory SUR2 subunits of the ATP-sensitive K+ (KATP) channel, as well as two mutations (V65M and C176S) in the Kir6.1 (KCNJ8) subunit. Previous analysis of leucine and alanine substitutions at the Val-65 equivalent site (Val-64) in Kir6.2 indicated no major effects on channel function...
August 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28814545/metabolic-differentiation-of-early-lyme-disease-from-southern-tick-associated-rash-illness-stari
#6
Claudia R Molins, Laura V Ashton, Gary P Wormser, Barbara G Andre, Ann M Hess, Mark J Delorey, Mark A Pilgard, Barbara J Johnson, Kristofor Webb, M Nurul Islam, Adoracion Pegalajar-Jurado, Irida Molla, Mollie W Jewett, John T Belisle
Lyme disease, the most commonly reported vector-borne disease in the United States, results from infection with Borrelia burgdorferi. Early clinical diagnosis of this disease is largely based on the presence of an erythematous skin lesion for individuals in high-risk regions. This, however, can be confused with other illnesses including southern tick-associated rash illness (STARI), an illness that lacks a defined etiological agent or laboratory diagnostic test, and is coprevalent with Lyme disease in portions of the eastern United States...
August 16, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28808716/spectroscopic-characterization-of-the-on-surface-induced-cyclo-dehydrogenation-of-a-n-heteroaromatic-compound-on-noble-metal-surfaces
#7
I Palacio, A L Pinardi, J I Martínez, A Preobrajenski, A Cossaro, A Jancarik, I Stará, I Starý, J Méndez, J A Martín-Gago, M F López
New nanoarchitectures can be built from polycyclic aromatic hydrocarbons (PAHs) by exploiting the capability of some metal surfaces for inducing cyclodehydrogenation reactions. This bottom-up approach allows the formation of nanostructures with a different dimensionality from the same precursor as a consequence of the diffusion and coupling of the PAHs adsorbed on the surface. In this work we present a thorough study, by means of a combination of X-ray photoemission spectroscopy, near-edge X-ray absorption fine structure and scanning tunneling microscopy with first principle calculations of the structural and chemical transformations undergone by pyridyl-substituted dibenzo[5]helicene on three coinage surfaces, namely Cu(110), Cu(111) and Au(111)...
August 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28794840/virtual-reality-distraction-decreases-routine-intravenous-sedation-and-procedure-related-pain-during-preoperative-adductor-canal-catheter-insertion-a-retrospective-study
#8
Pooja G Pandya, T Edward Kim, Steven K Howard, Erica Stary, Jody C Leng, Oluwatobi O Hunter, Edward R Mariano
BACKGROUND: Virtual reality (VR) distraction is a nonpharmacological method to prevent acute pain that has not yet been thoroughly explored for anesthesiology. We present our experience using VR distraction to decrease routine intravenous sedation for patients undergoing preoperative perineural catheter insertion. METHODS: This 1-month quality improvement project involved all elective unilateral primary total knee arthroplasty patients who received a preoperative adductor canal catheter...
August 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28767475/exaggerated-oculocardiac-reflex-elicited-by-local-anesthetic-injection-of-an-empty-orbit-a-case-report
#9
David Nicholson, Andrea Kossler, Katie Topping, Creed M Stary
We report the first description of oculocardiac reflex elicited with injection of local anesthetic in an empty orbit, and highlight clinical indicators for patients that may be at risk for an exaggerated oculocardiac reflex. We describe a patient with prior head and eye trauma treated for anophthalmic socket reconstruction at an outpatient eye surgery center. Injection of local anesthetic into the empty orbit induced an extended sinus arrest. This exaggerated response was avoided in a subsequent surgery by pretreatment with high-dose anticholinergics...
August 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28711067/pa-6-inhibits-inward-rectifier-currents-carried-by-v93i-and-d172n-gain-of-function-kir2-1-channels-but-increases-channel-protein-expression
#10
Yuan Ji, Marlieke G Veldhuis, Jantien Zandvoort, Fee L Romunde, Marien J C Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger, Marcel A G van der Heyden
BACKGROUND: The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate with increased IK1, short QT syndrome type 3 and congenital atrial fibrillation. Pentamidine-Analogue 6 (PA-6) is an efficient (IC50 = 14 nM with inside-out patch clamp methodology) and specific IK1 inhibitor that interacts with the cytoplasmic pore region of the KIR2...
July 15, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28705808/molecular-basis-of-altered-herg1-channel-gating-induced-by-ginsenoside-rg3
#11
Alison Gardner, Wei Wu, Steven Thomson, Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Michael C Sanguinetti
Outward current conducted by human ether-à-go-go-related gene type 1 (hERG1) channels is a major determinant of action potential repolarization in the human ventricle. Ginsenoside 20(S)-Rg3 [Rg3; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol], an alkaloid isolated from the root of Panax ginseng, slows the rate of hERG1 deactivation, induces channels to open at more negative potentials than normal, and increases current magnitude...
October 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28652602/standards-for-reporting-implementation-studies-stari-enhancing-reporting-to-improve-care
#12
EDITORIAL
Hilary Pinnock, Aziz Sheikh
No abstract text is available yet for this article.
June 26, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28649785/stari-aims-to-overcome-knowledge-translation-inertia-the-standards-for-reporting-implementation-studies-guidelines
#13
EDITORIAL
Christopher R Carpenter, Hilary Pinnock
No abstract text is available yet for this article.
June 26, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28609894/new-protoribates-acari-oribatida-haplozetidae-from-vietnam
#14
Sergey G Ermilov, Josef Starý
Three new species of oribatid mites of the genus Protoribates (Oribatida, Haplozetidae) are described based on adult specimens from the Tam Dao National Park of Northern Vietnam. Protoribates chistyakovi sp. nov. differs from P. sangumburiensis (Choi, 1996) by being larger, the localization of lamellar setae, and morphology of rostrum and interlamellar setae. Protoribates shaldybinae sp. nov. differs from P. dentatus (Berlese, 1883) by its distinctly foveolate body surface, morphology of pedotecta II and leg tarsi I and II, and much longer adanal setae ad2...
May 3, 2017: Zootaxa
https://www.readbyqxmd.com/read/28574631/starry-aims-to-overcome-knowledge-translation-inertia-the-standards-for-reporting-implementation-studies-stari-guidelines
#15
Christopher R Carpenter, Hilary Pinnock
No abstract text is available yet for this article.
August 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28552710/clinical-outcomes-and-testosterone-levels-following-continuous-androgen-deprivation-in-patients-with-relapsing-or-locally-advanced-prostate-cancer-a-post-hoc-analysis-of-the-iceland-study
#16
Bertrand Tombal, Erik B Cornel, Raj Persad, Anny Stari, Francisco Gómez Veiga, Claude Schulman
PURPOSE: Lower serum testosterone levels correlate with improved cause specific survival and longer time to progression in year 1 of continuous androgen deprivation in men with prostate cancer. ICELAND was a large European study demonstrating the efficacy of leuprorelin (Eligard®) during continuous androgen deprivation. In this post hoc analysis we investigated serum testosterone levels within year 1 of continuous androgen deprivation to determine survival and time to progression. MATERIALS AND METHODS: In ICELAND (ClinicalTrials...
May 25, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28522364/inhibition-of-mir-181a-protects-female-mice-from-transient-focal-cerebral-ischemia-by-targeting-astrocyte-estrogen-receptor-%C3%AE
#17
Creed M Stary, Lijun Xu, Le Li, Xiaoyun Sun, Yi-Bing Ouyang, Xiaoxing Xiong, Jing Zhao, Rona G Giffard
Whether the effect of miR-181a is sexually dimorphic in stroke is unknown. Prior work showed protection of male mice with miR-181a inhibition. Estrogen receptor-α (ERα) is an identified target of miR181 in endometrium. Therefore we investigated the separate and joint effects of miR-181a inhibition and 17β-estradiol (E2) replacement after ovariectomy. Adult female mice were ovariectomized and implanted with an E2- or vehicle-containing capsule for 14d prior to 1h middle cerebral artery occlusion (MCAO). Each group received either miR-181a antagomir or mismatch control by intracerebroventricular injection 24h before MCAO...
July 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28467407/beatbox-hpc-simulation-environment-for-biophysically-and-anatomically-realistic-cardiac-electrophysiology
#18
Mario Antonioletti, Vadim N Biktashev, Adrian Jackson, Sanjay R Kharche, Tomas Stary, Irina V Biktasheva
The BeatBox simulation environment combines flexible script language user interface with the robust computational tools, in order to setup cardiac electrophysiology in-silico experiments without re-coding at low-level, so that cell excitation, tissue/anatomy models, stimulation protocols may be included into a BeatBox script, and simulation run either sequentially or in parallel (MPI) without re-compilation. BeatBox is a free software written in C language to be run on a Unix-based platform. It provides the whole spectrum of multi scale tissue modelling from 0-dimensional individual cell simulation, 1-dimensional fibre, 2-dimensional sheet and 3-dimensional slab of tissue, up to anatomically realistic whole heart simulations, with run time measurements including cardiac re-entry tip/filament tracing, ECG, local/global samples of any variables, etc...
2017: PloS One
https://www.readbyqxmd.com/read/28417538/synthesis-of-long-oxahelicenes-by-polycyclization-in-a-flow-reactor
#19
Jindřich Nejedlý, Michal Šámal, Jiří Rybáček, Miroslava Tobrmanová, Florence Szydlo, Christophe Coudret, Maria Neumeier, Jaroslav Vacek, Jana Vacek Chocholoušová, Miloš Buděšínský, David Šaman, Lucie Bednárová, Ladislav Sieger, Irena G Stará, Ivo Starý
A series of oxahelicenes composed of ortho/meta-annulated benzene/pyridine and 2H-pyran rings were synthesized on the basis of the cobalt(I)-mediated (or rhodium(I)- or nickel(0)-mediated) double, triple, or quadruple [2+2+2] cycloisomerization of branched aromatic hexa-, nona-, or dodecaynes, thus allowing the construction of 6, 9, or 12 rings in a single operation. The use of a flow reactor was found to be beneficial for the multicyclization reactions. The stereogenic centers present in some of the oligoynes steered the helical folding in such a way that the final oxa[9]-, [13]-, [17]- and [19]helicenes were obtained in both enantiomerically and diastereomerically pure form...
April 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28395118/etv6-runx1-like-acute-lymphoblastic-leukemia-a-novel-b-cell-precursor-leukemia-subtype-associated-with-the-cd27-cd44-immunophenotype
#20
Marketa Zaliova, Michaela Kotrova, Silvia Bresolin, Jan Stuchly, Jan Stary, Ondrej Hrusak, Geertruy Te Kronnie, Jan Trka, Jan Zuna, Martina Vaskova
We have shown previously that ETV6/RUNX1-positive acute lymphoblastic leukemia (ALL) is distinguishable from other ALL subtypes by CD27(pos) /CD44(low-neg) immunophenotype. During diagnostic immunophenotyping of 573 childhood B-cell precursor ALL (BCP-ALL), we identified eight cases with this immunophenotype among "B-other ALL" (BCP-ALL cases negative for routinely tested chromosomal/genetic aberrations). We aimed to elucidate whether these cases belong to the recently described ETV6/RUNX1-like ALL defined by the ETV6/RUNX1-specific gene expression profile (GEP), harboring concurrent ETV6 and IKZF1 lesions...
August 2017: Genes, Chromosomes & Cancer
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