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https://www.readbyqxmd.com/read/29676572/asymmetric-synthesis-of-nonracemic-2-amino-6-helicenes-and-their-self-assembly-into-langmuir-films
#1
Manfred Karras, Jan Holec, Lucie Bednarova, Radek Pohl, Bernd Schmidt, Irena G Stará, Ivo Stary
Alternative ways of preparing nonracemic 2-amino[6]helicene derivatives were explored. The enantioselective [2 + 2 + 2] cycloisomerization of a nonchiral triyne under Ni(cod)2/(R)-QUINAP catalysis delivered the enantioenriched (+)-(P)-2-aminodibenzo[6]helicene derivative in 67% ee. An ultimate "point-to-helical" chirality transfer was observed in the cyclization of enantiopure triynes mediated by Ni(CO)2(PPh)2 affording (-)-(M)- or (+)-(P)-7,8-bis(p-tolyl)hexahelicen-2-amine in >99% ee as well as its benzoderivative in >99% ee...
April 20, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29645372/3-rd-science-days-of-the-austrian-society-of-dermatology-and-venereology-%C3%A3-gdv-forschungstage
#2
Christine M Prodinger, Georg Stary, Verena Paulitschke, Wolfram Hoetzenecker, Verena Moosbrugger-Martinz, Lisa Arzt, Matthias Schmuth
No abstract text is available yet for this article.
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29616745/in-situ-analysis-of-mast-cells-and-dendritic-cells-in-coronary-atherosclerosis-in-chronic-kidney-disease-ckd
#3
D L Wachter, D Neureiter, V Câmpean, K F Hilgers, M Büttner-Herold, C Daniel, K Benz, K Amann
AIMS: Mast cells (MC) and dendritic cells (DC) have immune modulatory function and can influence T-cell activity. Both cell types have been found in atherosclerotic plaques and are thought to play an important role for plaque stability. Compared to matched segments of the non-renal population, patients with chronic kidney disease (CKD) show a more pronounced and more aggressive course of atherosclerosis with higher plaque calcification and significantly higher complications rates. It was the aim of this study to analyze the number and localization of MCs and DCs, macrophages, T- and B-cells as well as the expression of markers of inflammation such as CRP and NFκB in calcified and non-calcified atherosclerotic plaques of patients with CKD and control patients...
April 4, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29589456/-laparoscopy-at-the-pediatric-surgery-department-for-a-five-year-period
#4
D Starý, J Tůma, R Doušek, R Macháček, J Škvařil, L Plánka
INTRODUCTION: Laparoscopy in small children was developed only after the adoption and verification of basic principles in adult patients and is mostly concentrated in specialized facilities due to the possible complications and necessity of follow-up specialized anesthesiological and post-operative care. In the 1990s, the Clinic of Paediatric Surgery, Orthopaedics and Traumatology at University Hospital Brno was one of the first in the Czech Republic to begin operating on children laparoscopically...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29550817/molecular-insights-into-herg-potassium-channel-blockade-by-lubeluzole
#5
Roberta Gualdani, Maria Maddalena Cavalluzzi, Francesco Tadini-Buoninsegni, Marino Convertino, Philippe Gailly, Anna Stary-Weinzinger, Giovanni Lentini
BACKGROUND/AIMS: Lubeluzole is a benzothiazole derivative that has shown neuroprotective properties in preclinical models of ischemic stroke. However, clinical research on lubeluzole is now at a standstill, since lubeluzole seems to be associated with the acquired long QT syndrome and ventricular arrhythmias. Since the cardiac cellular effects of lubeluzole have not been described thus far, an explanation for the lubeluzole-induced QT interval prolongation is lacking. METHODS: We tested the affinity of lubeluzole, its enantiomer, and the racemate for hERG channel using the patch-clamp technique...
March 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29477480/dehydroevodiamine-and-hortiamine-alkaloids-from-the-traditional-chinese-herbal-drug-evodia-rutaecarpa-are-i-kr-blockers-with-proarrhythmic-effects-in-vitro-and-in-vivo
#6
Igor Baburin, Rosanne Varkevisser, Anja Schramm, Priyanka Saxena, Stanislav Beyl, Phillip Szkokan, Tobias Linder, Anna Stary-Weinzinger, Marcel A G van der Heyden, Marien Houtman, Hiroki Takanari, Malin Jonsson, Jet H D Beekman, Matthias Hamburger, Marc A Vos, Steffen Hering
Evodiae fructus is a widely used herbal drug in traditional Chinese medicine. Evodia extract was found to inhibit hERG channels. The aim of the current study was to identify hERG inhibitors in Evodia extract and to investigate their potential proarrhythmic effects. Dehydroevodiamine (DHE) and hortiamine were identified as IKr (rapid delayed rectifier current) inhibitors in Evodia extract by HPLC-microfractionation and subsequent patch clamp studies on human embryonic kidney cells. DHE and hortiamine inhibited IKr with IC50 s of 253...
February 22, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29448937/engineering-chimeric-antigen-receptor-t-cells-for-cancer-treatment
#7
REVIEW
Baixin Ye, Creed M Stary, Xuejun Li, Qingping Gao, Chunsheng Kang, Xiaoxing Xiong
Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric antigen receptor (CAR) T-cell therapy has been successfully applied in the treatment of B-cell malignancies, underscoring its great potential in antitumor therapy. However, functional challenges of CAR-T cell therapy, especially in solid tumors, remain. Here, we describe cancer-immunity phenotypes from a clonal-stromal-immune perspective and elucidate mechanisms of T-cell exhaustion that contribute to tumor immune evasion...
February 15, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29353772/the-impact-of-development-of-atherosclerosis-on-delamination-resistance-of-the-thoracic-aortic-wall
#8
Marta Kozuń, Magdalena Kobielarz, Agnieszka Chwiłkowska, Celina Pezowicz
The aim of this work is to determine the impact of development of atherosclerosis on dissection of the human thoracic aorta on the basis of an analysis of the mechanical properties of the interfaces between its layers. The research material consisted of 17 pathologically unchanged aortae and 74 blood vessels with atherosclerotic lesions, which were classified according to the histological classification by Stary. The subject of the analysis were the interfaces between the adventitia and the media-intima complex (A-MIC) and between the intima and the media-adventitia complex (I-MAC)...
March 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29330525/distinct-modulation-of-inactivation-by-a-residue-in-the-pore-domain-of-voltage-gated-na-channels-mechanistic-insights-from-recent-crystal-structures
#9
Rene Cervenka, Peter Lukacs, Vaibhavkumar S Gawali, Song Ke, Xaver Koenig, Lena Rubi, Touran Zarrabi, Karlheinz Hilber, Walter Sandtner, Anna Stary-Weinzinger, Hannes Todt
Inactivation of voltage-gated Na+ channels (VGSC) is essential for the regulation of cellular excitability. The molecular rearrangement underlying inactivation is thought to involve the intracellular linker between domains III and IV serving as inactivation lid, the receptor for the lid (domain III S4-S5 linker) and the pore-lining S6 segements. To better understand the role of the domain IV S6 segment in inactivation we performed a cysteine scanning mutagenesis of this region in rNav 1.4 channels and screened the constructs for perturbations in the voltage-dependence of steady state inactivation...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29275621/large-converse-piezoelectric-effect-measured-on-a-single-molecule-on-a-metallic-surface
#10
Oleksandr Stetsovych, Pingo Mutombo, Martin Švec, Michal Šámal, Jindřich Nejedlý, Ivana Císařová, Héctor Vázquez, María Moro-Lagares, Jan Berger, Jaroslav Vacek, Irena G Stará, Ivo Starý, Pavel Jelínek
The converse piezoelectric effect is a phenomenon in which mechanical strain is generated in a material due to an applied electrical field. In this work, we demonstrate the converse piezoelectric effect in single heptahelicene-derived molecules on the Ag(111) surface using atomic force microscopy (AFM) and total energy density functional theory (DFT) calculations. The force-distance spectroscopy acquired over a wide range of bias voltages reveals a linear shift of the tip-sample distance at which the contact between the molecule and tip apex is established...
January 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29259247/ras-pathway-mutation-patterns-define-epigenetic-subclasses-in-juvenile-myelomonocytic-leukemia
#11
Daniel B Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik, Jens Langstein, Justyna A Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho, Christoph Plass
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling. Established clinical and genetic markers fail to fully recapitulate the clinical and biological heterogeneity of this disease. Here we report DNA methylome analysis and mutation profiling of 167 JMML samples. We identify three JMML subgroups with unique molecular and clinical characteristics. The high methylation group (HM) is characterized by somatic PTPN11 mutations and poor clinical outcome...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29245491/generic-revision-of-the-large-winged-mite-superfamily-galumnoidea-acari-oribatida-of-the-world
#12
Sergey G Ermilov, Pavel B Klimov
Genus-level taxa in the oribatid mite superfamily Galumnoidea (Acari, Oribatida) are revised based on morphology of adults and a previously published phylogenetic analysis. We give a concise overview of the general morphology of Galumnoidea, diagnoses and a key for families, genera, and subgenera, and a taxonomic list with two families, 39 genera, 9 non-nominal subgenera, and 590 species. The following nomenclatorial changes to genus-group taxa resulted from our revision: Allogalumna (Allogalumna) Grandjean, 1936 (=Xenogalumna Balogh, 1960(b) syn...
November 27, 2017: Zootaxa
https://www.readbyqxmd.com/read/29235578/are-we-any-closer-to-screening-for-colorectal-cancer-using-microbial-markers-a-critical-review
#13
Lubomir Stary, Kristyna Mezerova, Pavel Skalicky, Pavel Zboril, Vladislav Raclavsky
The role of gut microbiota in the development of sporadic colorectal cancer (CRC) is supported by a number of studies, however, the conclusiveness of published metagenomic studies is questioned by technical pitfalls and limited by small cohort sizes. In this review, we evaluate the current knowledge critically and outline practical solutions. We also list candidate CRC risk markers that are - in our opinion - well supported by available data and thus deserve clinical validation. Last but not least, we summarise available knowledge useful for improving care for patients immediately...
December 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29219788/differential-patterns-of-metastatic-dissemination-across-medulloblastoma-subgroups
#14
Michal Zapotocky, Daddy Mata-Mbemba, David Sumerauer, Petr Liby, Alvaro Lassaletta, Josef Zamecnik, Lenka Krskova, Martin Kyncl, Jan Stary, Suzanne Laughlin, Anthony Arnoldo, Cynthia Hawkins, Uri Tabori, Michael D Taylor, Eric Bouffet, Charles Raybaud, Vijay Ramaswamy
OBJECTIVE Metastatic dissemination is a major treatment challenge and cause of death in patients with medulloblastoma. However, the influence of molecular biology on the pattern of metastatic dissemination at diagnosis is not known. In this study, the authors sought to define the location, pattern, and imaging characteristics of medulloblastoma metastases across subgroups at diagnosis. METHODS A consecutive cohort of patients with metastatic medulloblastoma at The Hospital for Sick Children and the University Hospital Motol, who underwent up-front MRI of the craniospinal axis, was assembled and allocated to subgroups using NanoString limited gene-expression profiling...
February 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29210366/outcome-of-relapsed-infant-acute-lymphoblastic-leukemia-treated-on-the-interfant-99-protocol
#15
E M C Driessen, P de Lorenzo, M Campbell, M Felice, A Ferster, I Hann, A Vora, L Hovi, G Escherich, C K Li, G Mann, T Leblanc, F Locatelli, A Biondi, J Rubnitz, M Schrappe, L Silverman, J Stary, R Suppiah, T Szczepanski, M Valsecchi, R Pieters
This corrects the article DOI: 10.1038/leu.2015.246.
December 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29088958/a-systematic-review-of-perioperative-seizure-prophylaxis-during-brain-tumor-resection-the-case-for-a-multicenter-randomized-clinical-trial
#16
Vyshak Chandra, Andrew K Rock, Charles Opalak, Joel M Stary, Adam P Sima, Matthew Carr, Rafael A Vega, William C Broaddus
OBJECTIVE The majority of neurosurgeons administer antiepileptic drugs (AEDs) prophylactically for supratentorial tumor resection without clear evidence to support this practice. The putative benefit of perioperative seizure prophylaxis must be weighed against the risks of adverse effects and drug interactions in patients without a history of seizures. Consequently, the authors conducted a systematic review of prospective randomized controlled trials (RCTs) that have evaluated the efficacy of perioperative seizure prophylaxis among patients without a history of seizures...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29079599/predictive-value-of-minimal-residual-disease-in-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-treated-with-imatinib-in-the-european-intergroup-study-of-post-induction-treatment-of-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
#17
Giovanni Cazzaniga, Paola De Lorenzo, Julia Alten, Silja Röttgers, Jeremy Hancock, Vaskar Saha, Anders Castor, Hans O Madsen, Virginie Gandemer, Hélène Cavé, Veronica Leoni, Rolf Köhler, Giulia M Ferrari, Kirsten Bleckmann, Rob Pieters, Vincent van der Velden, Jan Stary, Jan Zuna, Gabriele Escherich, Udo Zur Stadt, Maurizio Aricò, Valentino Conter, Martin Schrappe, Maria Grazia Valsecchi, Andrea Biondi
The prognostic value of minimal residual disease (MRD) in Philadelphia-chromosome-positive (Ph+) childhood acute lymphoblastic leukemia (ALL) treated with tyrosine kinase inhibitors is not fully established. We detected MRD by real-time quantitative polymerase chain reaction (RQ-PCR) of rearranged immunoglobulin/T-cell receptor genes (IG/TR) and/or BCR/ABL1 fusion transcript to investigate its predictive value in patients receiving Berlin-Frankfurt-Münster (BFM) high-risk (HR) therapy and post-induction intermittent imatinib (the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia (EsPhALL) study)...
January 2018: Haematologica
https://www.readbyqxmd.com/read/28964114/fast-slow-asymptotics-for-a-markov-chain-model-of-fast-sodium-current
#18
Tomáš Starý, Vadim N Biktashev
We explore the feasibility of using fast-slow asymptotics to eliminate the computational stiffness of discrete-state, continuous-time deterministic Markov chain models of ionic channels underlying cardiac excitability. We focus on a Markov chain model of fast sodium current, and investigate its asymptotic behaviour with respect to small parameters identified in different ways.
September 2017: Chaos
https://www.readbyqxmd.com/read/28866212/growth-of-a-tinb-adhesion-interlayer-for-bioactive-coatings
#19
Zdeněk Tolde, Vladimír Starý, Ladislav Cvrček, Marta Vandrovcová, Jan Remsa, Stanislav Daniš, Jan Krčil, Lucie Bačáková, Petr Špatenka
Surface bioactivity has been under intensive study with reference to its use in medical implants. Our study is focused on coatings prepared from an electroactive material which can support bone cell adhesion. Until now, hydroxyapatite films have usually been utilized as a chemically-active surface agent. However, electrically-active films could set a new direction in hard tissue replacement. As a base for these films, it is necessary to prepare an intermediate film, which can serve as a suitable barrier against the possible diffusion of some allergens and toxic elements from the substrate...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28853493/staphylococcal-scalded-skin-syndrome-caused-by-a-rare-variant-of-exfoliative-toxin-a-s-aureus-in-an-adult-immunocompromised-woman
#20
Simona Saluzzo, Franziska Layer, Georg Stingl, Georg Stary
No abstract text is available yet for this article.
January 12, 2018: Acta Dermato-venereologica
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