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https://www.readbyqxmd.com/read/28221353/from-helical-to-planar-chirality-by-on-surface-chemistry
#1
Oleksandr Stetsovych, Martin Švec, Jaroslav Vacek, Jana Vacek Chocholoušová, Andrej Jančařík, Jiří Rybáček, Krzysztof Kosmider, Irena G Stará, Pavel Jelínek, Ivo Starý
The chirality of molecular structures is paramount in many phenomena, including enantioselective reactions, molecular self-assembly, biological processes and light or electron-spin polarization. Flat prochiral molecules, which are achiral in the gas phase or solution, can exhibit adsorption-induced chirality when deposited on surfaces. The whole array of such molecular adsorbates is naturally racemic as spontaneous global mirror-symmetry breaking is disfavoured. Here we demonstrate a chemical method of obtaining flat prochiral molecules adsorbed on the solid achiral surface in such a way that a specific adsorbate handedness globally dominates...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28214317/%C3%A3-gdv-jahrestagung-2016-25-27-november-2016-hofburg-wien
#2
Angelika Stary, Claudia Heller-Vitouch
No abstract text is available yet for this article.
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28180309/predominant-role-of-dna-polymerase-eta-and-p53-dependent-translesion-synthesis-in-the-survival-of-ultraviolet-irradiated-human-cells
#3
Leticia K Lerner, Guilherme Francisco, Daniela T Soltys, Clarissa R R Rocha, Annabel Quinet, Alexandre T Vessoni, Ligia P Castro, Taynah I P David, Silvina O Bustos, Bryan E Strauss, Vanesa Gottifredi, Anne Stary, Alain Sarasin, Roger Chammas, Carlos F M Menck
No abstract text is available yet for this article.
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28123412/exploring-and-exploiting-unique-properties-of-the-hippocampal-dentate-gyrus-for-post-stroke-therapy-astrocytes-link-ischemic-resistance-with-neurogenic-potential
#4
https://www.readbyqxmd.com/read/28122051/low-cytochrome-oxidase-1-links-mitochondrial-dysfunction-to-atherosclerosis-in-mice-and-pigs
#5
Paul Holvoet, Maarten Vanhaverbeke, Benjamine Geeraert, Dieuwke De Keyzer, Maarten Hulsmans, Stefan Janssens
BACKGROUND: Cytochrome oxidase IV complex regulates energy production in mitochondria. Therefore, we determined the relation of COX genes with atherosclerosis in mice and pigs. METHODS AND RESULTS: First, we compared atherosclerosis in the aortic arch of age-matched (24 weeks) C57BL/6J control (n = 10), LDL-receptor deficient (n = 8), leptin-deficient ob/ob (n = 10), and double knock-out (lacking LDL-receptor and leptin) mice (n = 12). Low aortic mitochondria-encoded cytochrome oxidase 1 in obese diabetic double knock-out mice was associated with a larger plaque area and higher propensity of M1 macrophages and oxidized LDL...
2017: PloS One
https://www.readbyqxmd.com/read/28116322/genetically-modified-t-cell-based-adoptive-immunotherapy-in-hematological-malignancies
#6
REVIEW
Baixin Ye, Creed M Stary, Qingping Gao, Qiongyu Wang, Zhi Zeng, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong
A significant proportion of hematological malignancies remain limited in treatment options. Immune system modulation serves as a promising therapeutic approach to eliminate malignant cells. Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity; unfortunately, nonspecific approaches for targeted recognition of tumor cells by CTLs to mediate tumor immune evasion in hematological malignancies imply multiple mechanisms, which may or may not be clinically relevant. Recently, genetically modified T-cell-based adoptive immunotherapy approaches, including chimeric antigen receptor (CAR) T-cell therapy and engineered T-cell receptor (TCR) T-cell therapy, promise to overcome immune evasion by redirecting the specificity of CTLs to tumor cells...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28109880/dynamics-of-the-eag1-k-channel-selectivity-filter-assessed-by-molecular-dynamics-simulations
#7
Harald Bernsteiner, Michael Bründl, Anna Stary-Weinzinger
EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure of these channels in atomic detail, allowing computational investigations. In this study, we performed molecular dynamics simulations to investigate the ion binding sites and the dynamical behavior of the selectivity filter. Our simulations suggest that sites S2 and S4 form stable ion binding sites, while ions placed at sites S1 and S3 rapidly switched to sites S2 and S4...
January 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28102409/reversal-of-the-sense-of-enantioselectivity-between-1-and-2-aza-6-helicenes-used-as-chiral-inducers-of-asymmetric-autocatalysis
#8
Arimasa Matsumoto, Kento Yonemitsu, Hanae Ozaki, Jiří Míšek, Ivo Starý, Irena G Stará, Kenso Soai
Reversal of the sense of enantioselectivity was observed between 1-aza[6]helicene 2 and 2-aza[6]helicene 3 employed as chiral inducers of asymmetric autocatalysis of pyrimidyl alkanol. In the presence of (P)-(+)-1-aza[6]helicene 2, the reaction of pyrimidine-5-carbaldehyde 1 with diisopropylzinc afforded, in conjunction with asymmetric autocatalysis, (S)-pyrimidyl alkanol 4 with high ee. Surprisingly, the reaction in the presence of (P)-(+)-2-aza[6]helicene 3 gave the opposite enantiomer of (R)-alkanol 4 with high ee...
January 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27956668/the-inflammasome-as-a-target-for-pain-therapy
#9
H Zhang, F Li, W-W Li, C Stary, J D Clark, S Xu, X Xiong
The interleukin-1 family of cytokines are potent inducers of inflammation and pain. Proteolytic activation of this family of cytokines is under the control of several innate immune receptors that coordinate to form large multiprotein signalling platforms, termed inflammasomes. Recent evidence suggests that a wide range of inflammatory diseases, cancers, and metabolic and autoimmune disorders, in which pain is a common complaint, may be coordinated by inflammasomes. Activation of inflammasomes results in cleavage of caspase-1, which subsequently induces downstream initiation of several potent pro-inflammatory cascades...
December 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27922214/implementation-challenges-for-tier-one-and-tier-two-school-based-programs-for-early-adolescents
#10
Maria D LaRusso, Suzanne Donovan, Catherine Snow
This mixed-method study examined the implementation and the challenges to implementation for participants in randomized controlled trials of two school-based programs for early adolescents: the Tier One Word Generation (WG) program, and the Tier Two Strategic Adolescent Reading Intervention (STARI). Levels of implementation for WG and STARI varied substantially across teachers and classrooms, with mean levels of 40% for fourth- and fifth-grade WG, 31% for sixth- and seventh-grade WG, and 47% for STARI. The three most common implementation challenges for WG were lack of time, multiple new programs/curricula happening at the same time, and time lost to testing and test prep...
December 2016: New Directions for Child and Adolescent Development
https://www.readbyqxmd.com/read/27915231/predominant-role-of-dna-polymerase-eta-and-p53-dependent-translesion-synthesis-in-the-survival-of-ultraviolet-irradiated-human-cells
#11
Leticia K Lerner, Guilherme Francisco, Daniela T Soltys, Clarissa R R Rocha, Annabel Quinet, Alexandre T Vessoni, Ligia P Castro, Taynah I P David, Silvina O Bustos, Bryan E Strauss, Vanesa Gottifredi, Anne Stary, Alain Sarasin, Roger Chammas, Carlos F M Menck
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53 also plays an important role in preventing cell death after ultraviolet (UV) light exposure. Intriguingly, we show that p53 does so by favoring translesion DNA synthesis by pol eta. In fact, the p53-dependent induction of pol eta in normal and DNA repair-deficient XP-C human cells after UV exposure has a protective effect on cell survival after challenging UV exposures, which was absent in p53- and Pol H-silenced cells...
December 2, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27879099/verleihung-der-goldmedaille-der-%C3%A3-sterreichischen-gesellschaft-f%C3%A3-r-dermatologie-und-venerologie-an-otto-braun-falco
#12
Angelika Stary
No abstract text is available yet for this article.
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27811724/re-visiting-the-aphidius-urticae-s-str-group-re-description-of-aphidius-rubi-star%C3%A3-and-a-silvaticus-star%C3%A3-hymenoptera-braconidae-aphidiinae
#13
Aiman Jamhour, Milana Mitrović, Andjeljko Petrović, Petr Starý, Željko Tomanović
Here we tested Aphidius urticae s. str. host-associated lineages from Microlophium carnosum (Buckton), Amphorophora rubi (Kaltenbach), Macrosiphum funestum (Macchiati) and Aulacorthum vaccinii Hille Ris Lambers with the barcoding region of the mitochondrial cytochrome oxidase subunit I gene used to analyse population differences and elucidate phylogenetic relationships between the separated taxa. This molecular marker has been shown to be the most informative molecular marker in resolving species complexes in aphidiine parasitoids...
October 24, 2016: Zootaxa
https://www.readbyqxmd.com/read/27782411/growth-kinetics-of-racemic-heptahelicene-2-carboxylic-acid-nanowires-on-calcite-104
#14
Mario Einax, Tobias Richter, Markus Nimmrich, Philipp Rahe, Irena G Stará, Ivo Starý, Angelika Kühnle, Philipp Maass
Molecular self-assembly of racemic heptahelicene-2-carboxylic acid on a dielectric substrate at room temperature can be used to generate wire-like organic nanostructures consisting of single and double molecular rows. By means of non-contact atomic force microscopy, we investigate the growth of the wire-like pattern after deposition by experimental and theoretical means. From analyzing the time dependence of the mean row length, two distinct regimes were found. At the early post-deposition stage, the mean length grows in time...
October 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27777645/targeting-glial-mitochondrial-function-for-protection-from-cerebral-ischemia-relevance-mechanisms-and-the-role-of-micrornas
#15
REVIEW
Le Li, Creed M Stary
Astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. MicroRNAs (miRs) are important posttranscriptional regulators of gene expression that function by inhibiting the translation of select target genes. In astrocytes, miR expression patterns regulate mitochondrial function in response to oxidative stress via targeting of Bcl2 and heat shock protein 70 family members. Mitochondria play an active role in microglial activation, and miRs regulate the microglial neuroinflammatory response...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27671317/transient-receptor-potential-vanilloid-1-regulates-mitochondrial-membrane-potential-and-myocardial-reperfusion-injury
#16
Carl M Hurt, Yao Lu, Creed M Stary, Honit Piplani, Bryce A Small, Travis J Urban, Nir Qvit, Garrett J Gross, Daria Mochly-Rosen, Eric R Gross
BACKGROUND: The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown. We studied whether myocardial injury is regulated by TRPV1 and whether we could mitigate reperfusion injury by limiting the calcineurin interaction with TRPV1. METHODS AND RESULTS: In primary cardiomyocytes, confocal and electron microscopy demonstrates that TRPV1 is localized to the mitochondria...
26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27660055/diverse-responses-of-wild-and-cultivated-tomato-to-baba-oligandrin-and-oidium-neolycopersici-infection
#17
Pavla Satková, Tomáš Starý, Veronika Plešková, Martina Zapletalová, Tomáš Kašparovský, Lucie Činčalová-Kubienová, Lenka Luhová, Barbora Mieslerová, Jaromír Mikulík, Jan Lochman, Marek Petřivalský
BACKGROUND AND AIMS: Current strategies for increased crop protection of susceptible tomato plants against pathogen infections include treatment with synthetic chemicals, application of natural pathogen-derived compounds or transfer of resistance genes from wild tomato species within breeding programmes. In this study, a series of 45 genes potentially involved in defence mechanisms was retrieved from the genome sequence of inbred reference tomato cultivar Solanum lycopersicum 'Heinz 1706'...
September 22, 2016: Annals of Botany
https://www.readbyqxmd.com/read/27638003/nas-agar-is-more-suitable-than-mckay-agar-for-primary-culture-of-streptococcus-milleri-group-smg-fastidious-bacteria-s-intermedius-in-particular
#18
COMPARATIVE STUDY
Vladislav Raclavsky, Radko Novotny, Lubomir Stary, Lucie Navratilova, Jaromir Zatloukal, Petr Jakubec, Martin Zapalka, Frantisek Kopriva, Vitezslav Kolek
Streptococcus milleri group (SMG) is a group of three streptococcal species (S. anginosus, intermedius and constellatus) that act as opportunist pathogens, among others in cystic fibrosis. Due to their fastidious character, they are both difficult to cultivate and to differentiate from less pathogenic streptococcal species, therefore being most probably underdiagnosed. Semi-selective McKay agar and NAS agar were developed to facilitate SMG recovery from clinical samples; however, direct comparison of recovery rates has not been published yet...
January 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/27625363/distinct-bilineal-leukemia-immunophenotypes-are-not-genetically-determined
#19
LETTER
Michaela Kotrova, Alena Musilova, Jan Stuchly, Karel Fiser, Julia Starkova, Ester Mejstrikova, Jan Stary, Jan Zuna, Ondrej Hrusak, Jan Trka, Marketa Zaliova
No abstract text is available yet for this article.
November 3, 2016: Blood
https://www.readbyqxmd.com/read/27553862/mir-29a-differentially-regulates-cell-survival-in-astrocytes-from-cornu-ammonis-1-and-dentate-gyrus-by-targeting-vdac1
#20
Creed M Stary, Xiaoyun Sun, YiBing Ouyang, Le Li, Rona G Giffard
Neurons in the cornu ammonis 1 (CA1) region of the hippocampus are vulnerable to cerebral ischemia, while dentate gyrus (DG) neurons are more resistant. This effect is mediated by local astrocytes, and may reflect differences in subregional hippocampal expression of miR-29a. We investigated the role of miR-29a on survival of hippocampal astrocytes cultured selectively from CA1 and DG in response to glucose deprivation (GD). CA1 astrocytes exhibited more cell death and a greater decrease in miR-29a than DG astrocytes...
September 2016: Mitochondrion
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