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Arimasa Matsumoto, Kento Yonemitsu, Hanae Ozaki, Jiří Míšek, Ivo Starý, Irena G Stará, Kenso Soai
Reversal of the sense of enantioselectivity was observed between 1-aza[6]helicene 2 and 2-aza[6]helicene 3 employed as chiral inducers of asymmetric autocatalysis of pyrimidyl alkanol. In the presence of (P)-(+)-1-aza[6]helicene 2, the reaction of pyrimidine-5-carbaldehyde 1 with diisopropylzinc afforded, in conjunction with asymmetric autocatalysis, (S)-pyrimidyl alkanol 4 with high ee. Surprisingly, the reaction in the presence of (P)-(+)-2-aza[6]helicene 3 gave the opposite enantiomer of (R)-alkanol 4 with high ee...
January 19, 2017: Organic & Biomolecular Chemistry
H Zhang, F Li, W-W Li, C Stary, J D Clark, S Xu, X Xiong
The interleukin-1 family of cytokines are potent inducers of inflammation and pain. Proteolytic activation of this family of cytokines is under the control of several innate immune receptors that coordinate to form large multiprotein signalling platforms, termed inflammasomes. Recent evidence suggests that a wide range of inflammatory diseases, cancers, and metabolic and autoimmune disorders, in which pain is a common complaint, may be coordinated by inflammasomes. Activation of inflammasomes results in cleavage of caspase-1, which subsequently induces downstream initiation of several potent pro-inflammatory cascades...
December 2016: British Journal of Anaesthesia
Maria D LaRusso, Suzanne Donovan, Catherine Snow
This mixed-method study examined the implementation and the challenges to implementation for participants in randomized controlled trials of two school-based programs for early adolescents: the Tier One Word Generation (WG) program, and the Tier Two Strategic Adolescent Reading Intervention (STARI). Levels of implementation for WG and STARI varied substantially across teachers and classrooms, with mean levels of 40% for fourth- and fifth-grade WG, 31% for sixth- and seventh-grade WG, and 47% for STARI. The three most common implementation challenges for WG were lack of time, multiple new programs/curricula happening at the same time, and time lost to testing and test prep...
December 2016: New Directions for Child and Adolescent Development
Leticia K Lerner, Guilherme Francisco, Daniela T Soltys, Clarissa R R Rocha, Annabel Quinet, Alexandre T Vessoni, Ligia P Castro, Taynah I P David, Silvina O Bustos, Bryan E Strauss, Vanesa Gottifredi, Anne Stary, Alain Sarasin, Roger Chammas, Carlos F M Menck
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53 also plays an important role in preventing cell death after ultraviolet (UV) light exposure. Intriguingly, we show that p53 does so by favoring translesion DNA synthesis by pol eta. In fact, the p53-dependent induction of pol eta in normal and DNA repair-deficient XP-C human cells after UV exposure has a protective effect on cell survival after challenging UV exposures, which was absent in p53- and Pol H-silenced cells...
December 2, 2016: Nucleic Acids Research
Angelika Stary
No abstract text is available yet for this article.
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Aiman Jamhour, Milana Mitrović, Andjeljko Petrović, Petr Starý, Željko Tomanović
Here we tested Aphidius urticae s. str. host-associated lineages from Microlophium carnosum (Buckton), Amphorophora rubi (Kaltenbach), Macrosiphum funestum (Macchiati) and Aulacorthum vaccinii Hille Ris Lambers with the barcoding region of the mitochondrial cytochrome oxidase subunit I gene used to analyse population differences and elucidate phylogenetic relationships between the separated taxa. This molecular marker has been shown to be the most informative molecular marker in resolving species complexes in aphidiine parasitoids...
October 24, 2016: Zootaxa
Mario Einax, Tobias Richter, Markus Nimmrich, Philipp Rahe, Irena G Stará, Ivo Starý, Angelika Kühnle, Philipp Maass
Molecular self-assembly of racemic heptahelicene-2-carboxylic acid on a dielectric substrate at room temperature can be used to generate wire-like organic nanostructures consisting of single and double molecular rows. By means of non-contact atomic force microscopy, we investigate the growth of the wire-like pattern after deposition by experimental and theoretical means. From analyzing the time dependence of the mean row length, two distinct regimes were found. At the early post-deposition stage, the mean length grows in time...
October 7, 2016: Journal of Chemical Physics
Le Li, Creed M Stary
Astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. MicroRNAs (miRs) are important posttranscriptional regulators of gene expression that function by inhibiting the translation of select target genes. In astrocytes, miR expression patterns regulate mitochondrial function in response to oxidative stress via targeting of Bcl2 and heat shock protein 70 family members. Mitochondria play an active role in microglial activation, and miRs regulate the microglial neuroinflammatory response...
2016: Oxidative Medicine and Cellular Longevity
Carl M Hurt, Yao Lu, Creed M Stary, Honit Piplani, Bryce A Small, Travis J Urban, Nir Qvit, Garrett J Gross, Daria Mochly-Rosen, Eric R Gross
BACKGROUND: The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown. We studied whether myocardial injury is regulated by TRPV1 and whether we could mitigate reperfusion injury by limiting the calcineurin interaction with TRPV1. METHODS AND RESULTS: In primary cardiomyocytes, confocal and electron microscopy demonstrates that TRPV1 is localized to the mitochondria...
26, 2016: Journal of the American Heart Association
Pavla Satková, Tomáš Starý, Veronika Plešková, Martina Zapletalová, Tomáš Kašparovský, Lucie Činčalová-Kubienová, Lenka Luhová, Barbora Mieslerová, Jaromír Mikulík, Jan Lochman, Marek Petřivalský
BACKGROUND AND AIMS: Current strategies for increased crop protection of susceptible tomato plants against pathogen infections include treatment with synthetic chemicals, application of natural pathogen-derived compounds or transfer of resistance genes from wild tomato species within breeding programmes. In this study, a series of 45 genes potentially involved in defence mechanisms was retrieved from the genome sequence of inbred reference tomato cultivar Solanum lycopersicum 'Heinz 1706'...
September 22, 2016: Annals of Botany
Vladislav Raclavsky, Radko Novotny, Lubomir Stary, Lucie Navratilova, Jaromir Zatloukal, Petr Jakubec, Martin Zapalka, Frantisek Kopriva, Vitezslav Kolek
Streptococcus milleri group (SMG) is a group of three streptococcal species (S. anginosus, intermedius and constellatus) that act as opportunist pathogens, among others in cystic fibrosis. Due to their fastidious character, they are both difficult to cultivate and to differentiate from less pathogenic streptococcal species, therefore being most probably underdiagnosed. Semi-selective McKay agar and NAS agar were developed to facilitate SMG recovery from clinical samples; however, direct comparison of recovery rates has not been published yet...
September 16, 2016: Folia Microbiologica
Michaela Kotrova, Alena Musilova, Jan Stuchly, Karel Fiser, Julia Starkova, Ester Mejstrikova, Jan Stary, Jan Zuna, Ondrej Hrusak, Jan Trka, Marketa Zaliova
No abstract text is available yet for this article.
September 13, 2016: Blood
Creed M Stary, Xiaoyun Sun, YiBing Ouyang, Le Li, Rona G Giffard
Neurons in the cornu ammonis 1 (CA1) region of the hippocampus are vulnerable to cerebral ischemia, while dentate gyrus (DG) neurons are more resistant. This effect is mediated by local astrocytes, and may reflect differences in subregional hippocampal expression of miR-29a. We investigated the role of miR-29a on survival of hippocampal astrocytes cultured selectively from CA1 and DG in response to glucose deprivation (GD). CA1 astrocytes exhibited more cell death and a greater decrease in miR-29a than DG astrocytes...
September 2016: Mitochondrion
Jiří Klívar, Andrej Jančařík, David Šaman, Radek Pohl, Pavel Fiedler, Lucie Bednárová, Ivo Starý, Irena G Stará
We have developed a methodology for the synthesis of pyridohelicenes and their analogues based on the Ni(0) -, Co(I) - or Rh(I) -mediated intramolecular [2+2+2] cycloisomerisation of cyanodiynes. It allows for folding the linear precursors into the corresponding helical backbones comprising the newly formed pyridine unit in their central part. Along with racemic pyrido[n]helicenes (n=5,6,7) and their derivatives, both enantio- and diastereomerically pure pyrido[n]helicene-like molecules (n=5,6) were prepared by employing the chiral substrate-controlled cyclisation of the corresponding enantiopure cyanodiynes...
September 26, 2016: Chemistry: a European Journal
Sun-Joo Lee, Feifei Ren, Eva-Maria Zangerl-Plessl, Sarah Heyman, Anna Stary-Weinzinger, Peng Yuan, Colin G Nichols
Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP2) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but interaction of bulk anionic phospholipid (PL(-)) with a distinct second site is required for high PIP2 sensitivity. Here we show that introduction of a lipid-partitioning tryptophan at the second site (K62W) generates high PIP2 sensitivity, even in the absence of PL(-) Furthermore, high-resolution x-ray crystal structures of Kir2...
September 2016: Journal of General Physiology
Eliska Potuckova, Jan Zuna, Lenka Hovorkova, Julia Starkova, Jan Stary, Jan Trka, Marketa Zaliova
Intragenic ERG deletions occur in 3-5% of B-cell precursor acute lymphoblastic leukemia, specifically in B-other subtype lacking the classifying genetic lesions. They represent the only genetic lesion described so far present in the majority of cases clustering into a subgroup of B-other subtype characterized by a unique gene expression profile, probably sharing a common, however, not yet fully described, biological background. We aimed to elucidate whether ERG deletions could drive the specific biology of this ERG-related leukemia subgroup through expression of aberrant or decreased expression of wild type ERG isoforms...
2016: PloS One
Ondřej Pelák, Daniela Kužílková, Daniel Thürner, Marie-Luise Kiene, Kristian Stanar, Jan Stuchlý, Martina Vášková, Jan Starý, Ondřej Hrušák, Herbert Stadler, Tomáš Kalina
In mass cytometry, the isolation of pure lymphocytes is very important to obtain reproducible results and to shorten the time spent on data acquisition. To prepare highly purified cell suspensions of peripheral blood lymphocytes for further analysis on mass cytometer, we used the new CD81+ immune affinity chromatography cell isolation approach. Using 21 metal conjugated antibodies in a single tube we were able to identify all basic cell subsets and compare their relative abundance in final products obtained by density gradient (Ficoll-Paque) and immune affinity chromatography (CD81+ T-catch™) isolation approach...
August 4, 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
Susanne Jacobsson, Daniel Golparian, Michelle Cole, Gianfranco Spiteri, Irene Martin, Thea Bergheim, Maria José Borrego, Brendan Crowley, Tania Crucitti, Alje P Van Dam, Steen Hoffmann, Samo Jeverica, Peter Kohl, Beata Mlynarczyk-Bonikowska, Gatis Pakarna, Angelika Stary, Paola Stefanelli, Peter Pavlik, Eva Tzelepi, Raquel Abad, Simon R Harris, Magnus Unemo
OBJECTIVES: To elucidate the genome-based epidemiology and phylogenomics of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae strains collected in 2009-14 in Europe and clarify the azithromycin resistance mechanisms. METHODS: Seventy-five azithromycin-resistant (MIC 4 to >256 mg/L) N. gonorrhoeae isolates collected in 17 European countries during 2009-14 were examined using antimicrobial susceptibility testing and WGS. RESULTS: Thirty-six N...
November 2016: Journal of Antimicrobial Chemotherapy
Wojciech Niedbała, Josef Starý
In six sifting litter samples from Madagascar, altogether 26 species of ptyctimous mites, belonging to four families and 11 genera, were found. Three new species, Arphthicarus phoxos sp. nov., Notophthiracarus parapaulianus sp. nov. and Atropacarus (Hoplophorella) paralemurius sp. nov. are described and figured. Keys for species of genera and subgenera Arphthicarus, Notophthiracarus and Atropacarus (Hoplophorella) from Madagascar are presented.
April 18, 2016: Zootaxa
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