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https://www.readbyqxmd.com/read/28522364/inhibition-of-mir-181a-protects-female-mice-from-transient-focal-cerebral-ischemia-by-targeting-astrocyte-estrogen-receptor-%C3%AE
#1
Creed M Stary, Lijun Xu, Le Li, Xiaoyun Sun, Yi-Bing Ouyang, Xiaoxing Xiong, Jing Zhao, Rona G Giffard
Whether the effect of miR-181a is sexually dimorphic in stroke is unknown. Prior work showed protection of male mice with miR-181a inhibition. Estrogen receptor-α (ERα) is an identified target of miR181 in endometrium. Therefore we investigated the separate and joint effects of miR-181a inhibition and 17β-estradiol (E2) replacement after ovariectomy. Adult female mice were ovariectomized and implanted with an E2- or vehicle-containing capsule for 14d prior to 1h middle cerebral artery occlusion (MCAO). Each group received either miR-181a antagomir or mismatch control by intracerebroventricular injection 24h before MCAO...
May 15, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28467407/beatbox-hpc-simulation-environment-for-biophysically-and-anatomically-realistic-cardiac-electrophysiology
#2
Mario Antonioletti, Vadim N Biktashev, Adrian Jackson, Sanjay R Kharche, Tomas Stary, Irina V Biktasheva
The BeatBox simulation environment combines flexible script language user interface with the robust computational tools, in order to setup cardiac electrophysiology in-silico experiments without re-coding at low-level, so that cell excitation, tissue/anatomy models, stimulation protocols may be included into a BeatBox script, and simulation run either sequentially or in parallel (MPI) without re-compilation. BeatBox is a free software written in C language to be run on a Unix-based platform. It provides the whole spectrum of multi scale tissue modelling from 0-dimensional individual cell simulation, 1-dimensional fibre, 2-dimensional sheet and 3-dimensional slab of tissue, up to anatomically realistic whole heart simulations, with run time measurements including cardiac re-entry tip/filament tracing, ECG, local/global samples of any variables, etc...
2017: PloS One
https://www.readbyqxmd.com/read/28417538/synthesis-of-long-oxahelicenes-by-polycyclization-in-a-flow-reactor
#3
Jindřich Nejedlý, Michal Šámal, Jiří Rybáček, Miroslava Tobrmanová, Florence Szydlo, Christophe Coudret, Maria Neumeier, Jaroslav Vacek, Jana Vacek Chocholoušová, Miloš Buděšínský, David Šaman, Lucie Bednárová, Ladislav Sieger, Irena G Stará, Ivo Starý
A series of oxahelicenes composed of ortho/meta-annulated benzene/pyridine and 2H-pyran rings were synthesized on the basis of the cobalt(I)-mediated (or rhodium(I)- or nickel(0)-mediated) double, triple, or quadruple [2+2+2] cycloisomerization of branched aromatic hexa-, nona-, or dodecaynes, thus allowing the construction of 6, 9, or 12 rings in a single operation. The use of a flow reactor was found to be beneficial for the multicyclization reactions. The stereogenic centers present in some of the oligoynes steered the helical folding in such a way that the final oxa[9]-, [13]-, [17]- and [19]helicenes were obtained in both enantiomerically and diastereomerically pure form...
April 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28395118/etv6-runx1-like-acute-lymphoblastic-leukemia-a-novel-b-cell-precursor-leukemia-subtype-associated-with-the-cd27-cd44-immunophenotype
#4
Marketa Zaliova, Michaela Kotrova, Silvia Bresolin, Jan Stuchly, Jan Stary, Ondrej Hrusak, Geertruy Te Kronnie, Jan Trka, Jan Zuna, Martina Vaskova
We have shown previously that ETV6/RUNX1-positive acute lymphoblastic leukemia (ALL) is distinguishable from other ALL subtypes by CD27(pos) /CD44(low-neg) immunophenotype. During diagnostic immunophenotyping of 573 childhood B-cell precursor ALL (BCP-ALL), we identified eight cases with this immunophenotype among "B-other ALL" (BCP-ALL cases negative for routinely tested chromosomal/genetic aberrations). We aimed to elucidate whether these cases belong to the recently described ETV6/RUNX1-like ALL defined by the ETV6/RUNX1-specific gene expression profile (GEP), harboring concurrent ETV6 and IKZF1 lesions...
April 10, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28378859/oxahelicene-nhc-ligands-in-the-asymmetric-synthesis-of-nonracemic-helicenes
#5
Isabel Gay Sánchez, Michal Šámal, Jindřich Nejedlý, Manfred Karras, Jiří Klívar, Jiří Rybáček, Miloš Buděšínský, Lucie Bednárová, Beata Seidlerová, Irena G Stará, Ivo Starý
A straightforward approach to enantiopure 2H-pyran-modified amino[5]helicenes and amino[6]helicenes was developed. They were converted to 1,3-disubstituted imidazolium salts and used as NHC ligand precursors in the Ni(0)-catalysed enantioselective [2+2+2] cycloisomerisation of aromatic triynes to obtain the model helicene derivatives in up to 86% ee.
April 5, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28378492/2nd-science-days-of-the-austrian-society-of-dermatology-and-venereology-%C3%A3-gdv-forschungstage
#6
Georg Stary, Sandrine Dubrac, Florian Gruber, Verena Paulitschke, Christine Prodinger, Matthias Schmuth
No abstract text is available yet for this article.
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28373250/standards-for-reporting-implementation-studies-stari-explanation-and-elaboration-document
#7
Hilary Pinnock, Melanie Barwick, Christopher R Carpenter, Sandra Eldridge, Gonzalo Grandes, Chris J Griffiths, Jo Rycroft-Malone, Paul Meissner, Elizabeth Murray, Anita Patel, Aziz Sheikh, Stephanie J C Taylor
OBJECTIVES: Implementation studies are often poorly reported and indexed, reducing their potential to inform the provision of healthcare services. The Standards for Reporting Implementation Studies (StaRI) initiative aims to develop guidelines for transparent and accurate reporting of implementation studies. METHODS: An international working group developed the StaRI guideline informed by a systematic literature review and e-Delphi prioritisation exercise. Following a face-to-face meeting, the checklist was developed iteratively by email discussion and critical review by international experts...
April 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28331056/monitoring-of-childhood-all-using-bcr-abl1-genomic-breakpoints-identifies-a-subgroup-with-cml-like-biology
#8
Lenka Hovorkova, Marketa Zaliova, Nicola C Venn, Kirsten Bleckmann, Marie Trkova, Eliska Potuckova, Martina Vaskova, Jana Linhartova, Katerina Machova Polakova, Eva Fronkova, Walter Muskovic, Jodie E Giles, Peter J Shaw, Gunnar Cario, Rosemary Sutton, Jan Stary, Jan Trka, Jan Zuna
We used the genomic breakpoint between BCR and ABL1 genes for the DNA-based monitoring of minimal residual disease (MRD) in 48 patients with childhood acute lymphoblastic leukemia (ALL). Comparing the results with standard MRD monitoring based on immunoglobulin/T-cell receptor (Ig/TCR) gene rearrangements and with quantification of IKZF1 deletion, we observed very good correlation for the methods in a majority of patients; however, over 20% of children (25% [8/32] with minor and 12.5% [1/8] with Major-BCR-ABL1 variants in the consecutive cohorts) had significantly (>1 log) higher levels of BCR-ABL1 fusion than Ig/TCR rearrangements and/or IKZF1 deletion...
March 22, 2017: Blood
https://www.readbyqxmd.com/read/28299344/advances-in-immunotherapy-for-glioblastoma-multiforme
#9
REVIEW
Boyuan Huang, Hongbo Zhang, Lijuan Gu, Bainxin Ye, Zhihong Jian, Creed Stary, Xiaoxing Xiong
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Patients with GBM have poor outcomes, even with the current gold-standard first-line treatment: maximal safe resection combined with radiotherapy and temozolomide chemotherapy. Accumulating evidence suggests that advances in antigen-specific cancer vaccines and immune checkpoint blockade in other advanced tumors may provide an appealing promise for immunotherapy in glioma. The future of therapy for GBM will likely incorporate a combinatorial, personalized approach, including current conventional treatments, active immunotherapeutics, plus agents targeting immunosuppressive checkpoints...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28284062/the-content-of-collagen-type-ii-in-human-arteries-is-correlated-with-the-stage-of-atherosclerosis-and-calcification-foci
#10
Aleksandra Kuzan, Agnieszka Chwiłkowska, Celina Pezowicz, Wojciech Witkiewicz, Andrzej Gamian, Krzysztof Maksymowicz, Magdalena Kobielarz
OBJECTIVE: The signature processes during atherosclerosis development are arterial calcification and accumulation in the arterial walls of proteins that are specific to bone and cartilage, e.g., collagen type II. The purpose of this study was to characterize localization of collagen type II and quantify its content in human arteries. RESULTS: The study was conducted on sections of thoracic and abdominal aortas (n=97) subjected to histological evaluation and classified into six grades according to the Stary scale of the atherosclerosis severity...
May 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28264797/standards-for-reporting-implementation-studies-stari-statement
#11
Hilary Pinnock, Melanie Barwick, Christopher R Carpenter, Sandra Eldridge, Gonzalo Grandes, Chris J Griffiths, Jo Rycroft-Malone, Paul Meissner, Elizabeth Murray, Anita Patel, Aziz Sheikh, Stephanie J C Taylor
Implementation studies are often poorly reported and indexed, reducing their potential to inform initiatives to improve healthcare services. The Standards for Reporting Implementation Studies (StaRI) initiative aimed to develop guidelines for transparent and accurate reporting of implementation studies. Informed by the findings of a systematic review and a consensus-building e-Delphi exercise, an international working group of implementation science experts discussed and agreed the StaRI Checklist comprising 27 items...
March 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28255018/acute-lymphoblastic-leukemia-with-aleukemic-prodrome-preleukemic-dynamics-and-possible-mechanisms-of-immunosurveillance
#12
Olga Zimmermannova, Marketa Zaliova, Anthony V Moorman, Halima Al-Shehhi, Eva Fronkova, Zuzana Zemanova, Tomas Kalina, Ajay Vora, Jan Stary, Jan Trka, Ondrej Hrusak, Jan Zuna
No abstract text is available yet for this article.
March 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28246725/anesthetic-neurotoxicity-an-emerging-role-for-glia-in-neuroprotection
#13
EDITORIAL
Josh D Bell, Creed M Stary
No abstract text is available yet for this article.
March 1, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28244980/next-generation-sequencing-indicates-false-positive-mrd-results-and-better-predicts-prognosis-after-sct-in-patients-with-childhood-all
#14
M Kotrova, V H J van der Velden, J J M van Dongen, R Formankova, P Sedlacek, M Brüggemann, J Zuna, J Stary, J Trka, E Fronkova
Minimal residual disease (MRD) monitoring via quantitative PCR (qPCR) detection of Ag receptor gene rearrangements has been the most sensitive method for predicting prognosis and making post-transplant treatment decisions for patients with ALL. Despite the broad clinical usefulness and standardization of this method, we and others have repeatedly reported the possibility of false-positive MRD results caused by massive B-lymphocyte regeneration after stem cell transplantation (SCT). Next-generation sequencing (NGS) enables precise and sensitive detection of multiple Ag receptor rearrangements, thus providing a more specific readout compared to qPCR...
February 27, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28221353/from-helical-to-planar-chirality-by-on-surface-chemistry
#15
Oleksandr Stetsovych, Martin Švec, Jaroslav Vacek, Jana Vacek Chocholoušová, Andrej Jančařík, Jiří Rybáček, Krzysztof Kosmider, Irena G Stará, Pavel Jelínek, Ivo Starý
The chirality of molecular structures is paramount in many phenomena, including enantioselective reactions, molecular self-assembly, biological processes and light or electron-spin polarization. Flat prochiral molecules, which are achiral in the gas phase or solution, can exhibit adsorption-induced chirality when deposited on surfaces. The whole array of such molecular adsorbates is naturally racemic as spontaneous global mirror-symmetry breaking is disfavoured. Here we demonstrate a chemical method of obtaining flat prochiral molecules adsorbed on the solid achiral surface in such a way that a specific adsorbate handedness globally dominates...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28214317/%C3%A3-gdv-jahrestagung-2016-25-27-november-2016-hofburg-wien
#16
Angelika Stary, Claudia Heller-Vitouch
No abstract text is available yet for this article.
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28180309/predominant-role-of-dna-polymerase-eta-and-p53-dependent-translesion-synthesis-in-the-survival-of-ultraviolet-irradiated-human-cells
#17
Leticia K Lerner, Guilherme Francisco, Daniela T Soltys, Clarissa R R Rocha, Annabel Quinet, Alexandre T Vessoni, Ligia P Castro, Taynah I P David, Silvina O Bustos, Bryan E Strauss, Vanesa Gottifredi, Anne Stary, Alain Sarasin, Roger Chammas, Carlos F M Menck
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53 also plays an important role in preventing cell death after ultraviolet (UV) light exposure. Intriguingly, we show that p53 does so by favoring translesion DNA synthesis by pol eta. In fact, the p53-dependent induction of pol eta in normal and DNA repair-deficient XP-C human cells after UV exposure has a protective effect on cell survival after challenging UV exposures, which was absent in p53- and Pol H-silenced cells...
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28123412/exploring-and-exploiting-unique-properties-of-the-hippocampal-dentate-gyrus-for-post-stroke-therapy-astrocytes-link-ischemic-resistance-with-neurogenic-potential
#18
https://www.readbyqxmd.com/read/28122051/low-cytochrome-oxidase-1-links-mitochondrial-dysfunction-to-atherosclerosis-in-mice-and-pigs
#19
Paul Holvoet, Maarten Vanhaverbeke, Benjamine Geeraert, Dieuwke De Keyzer, Maarten Hulsmans, Stefan Janssens
BACKGROUND: Cytochrome oxidase IV complex regulates energy production in mitochondria. Therefore, we determined the relation of COX genes with atherosclerosis in mice and pigs. METHODS AND RESULTS: First, we compared atherosclerosis in the aortic arch of age-matched (24 weeks) C57BL/6J control (n = 10), LDL-receptor deficient (n = 8), leptin-deficient ob/ob (n = 10), and double knock-out (lacking LDL-receptor and leptin) mice (n = 12). Low aortic mitochondria-encoded cytochrome oxidase 1 in obese diabetic double knock-out mice was associated with a larger plaque area and higher propensity of M1 macrophages and oxidized LDL...
2017: PloS One
https://www.readbyqxmd.com/read/28116322/genetically-modified-t-cell-based-adoptive-immunotherapy-in-hematological-malignancies
#20
REVIEW
Baixin Ye, Creed M Stary, Qingping Gao, Qiongyu Wang, Zhi Zeng, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong
A significant proportion of hematological malignancies remain limited in treatment options. Immune system modulation serves as a promising therapeutic approach to eliminate malignant cells. Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity; unfortunately, nonspecific approaches for targeted recognition of tumor cells by CTLs to mediate tumor immune evasion in hematological malignancies imply multiple mechanisms, which may or may not be clinically relevant. Recently, genetically modified T-cell-based adoptive immunotherapy approaches, including chimeric antigen receptor (CAR) T-cell therapy and engineered T-cell receptor (TCR) T-cell therapy, promise to overcome immune evasion by redirecting the specificity of CTLs to tumor cells...
2017: Journal of Immunology Research
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