keyword
MENU ▼
Read by QxMD icon Read
search

Developmental plasticity

keyword
https://www.readbyqxmd.com/read/28729483/epigenetic-plasticity-and-the-hallmarks-of-cancer
#1
REVIEW
William A Flavahan, Elizabeth Gaskell, Bradley E Bernstein
Chromatin and associated epigenetic mechanisms stabilize gene expression and cellular states while also facilitating appropriate responses to developmental or environmental cues. Genetic, environmental, or metabolic insults can induce overly restrictive or overly permissive epigenetic landscapes that contribute to pathogenesis of cancer and other diseases. Restrictive chromatin states may prevent appropriate induction of tumor suppressor programs or block differentiation. By contrast, permissive or "plastic" states may allow stochastic oncogene activation or nonphysiologic cell fate transitions...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28723558/dendritic-cell-lineage-potential-in-human-early-hematopoietic-progenitors
#2
Julie Helft, Fernando Anjos-Afonso, Annemarthe G van der Veen, Probir Chakravarty, Dominique Bonnet, Caetano Reis E Sousa
Conventional dendritic cells (cDCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). However, a mouse lymphoid-primed multipotent progenitor has been shown to generate cDCs following a DC-specific developmental pathway independent of monocyte and granulocyte poiesis. Similarly, here we show that, in humans, a large fraction of multipotent lymphoid early progenitors (MLPs) gives rise to cDCs, in particular the subset known as cDC1, identified by co-expression of DNGR-1 (CLEC9A) and CD141 (BDCA-3)...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28722313/cellular-glycosylation-senses-metabolic-changes-and-modulates-cell-plasticity-during-emt
#3
REVIEW
P Carvalho-Cruz, F Alisson-Silva, A R Todeschini, W B Dias
Epithelial to mesenchymal transition (EMT) is a developmental program reactivated by tumor cells that leads to the switch from epithelial to mesenchymal phenotype. During EMT, cells are transcriptionally regulated to decrease E-cadherin expression while expressing mesenchymal markers such as vimentin, fibronectin and N-cadherin. Growing body of evidences suggest that cells engaged in EMT undergo a metabolic reprograming process, redirecting glucose flux toward Hexosamine Biosynthesis Pathway (HBP) which fuels aberrant glycosylation patterns that are extensively observed in cancer cells...
July 19, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28717598/development-rate-rather-than-social-environment-influences-cognitive-performance-in-australian-black-field-crickets-teleogryllus-commodus
#4
Caitlin L Anderson, Michael M Kasumovic
Cognitive functioning is vital for enabling animals of all taxa to optimise their chances of survival and reproductive success. Learning and memory in particular are drivers of many evolutionary processes. In this study, we examine how developmental plasticity can affect cognitive ability by exploring the role the early social environment has on problem solving ability and learning of female black field crickets, Teleogryllus commodus. We used two learning paradigms, an analog of the Morris water maze and a novel linear maze, to examine cognitive differences between individuals reared in two acoustic treatments: silence or calling...
2017: PeerJ
https://www.readbyqxmd.com/read/28716037/phylogeny-expression-patterns-and-regulation-of-dna-methyltransferases-in-early-development-of-the-flatfish-solea-senegalensis
#5
Joana Firmino, Carlos Carballo, Paula Armesto, Marco A Campinho, Deborah M Power, Manuel Manchado
BACKGROUND: The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish. In this study, dnmt1 and dnmt3 paralogs were identified in the flatfish Solea senegalensis and expression patterns in early developmental stages and juveniles were determined. Additionally, the regulation of Dnmt transcription by a specific inhibitor (5-aza-2'-deoxycytidine) and temperature was evaluated...
July 17, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28715961/genetics-and-epigenetics-of-mating-type-determination-in-paramecium-and-tetrahymena
#6
Eduardo Orias, Deepankar Pratap Singh, Eric Meyer
While sex is an ancient and highly conserved eukaryotic invention, self-incompatibility systems such as mating types or sexes appear to be derived limitations that show considerable evolutionary plasticity. Within a single class of ciliates, Paramecium and Tetrahymena species have long been known to present a wide variety of mating type numbers and modes of inheritance, but only recently have the genes involved been identified. Although similar transmembrane proteins mediate self/nonself recognition in both ciliates, the mechanisms of mating type determination differ widely, ranging from Mendelian systems to developmental nuclear differentiation, either stochastic or maternally inherited...
July 17, 2017: Annual Review of Microbiology
https://www.readbyqxmd.com/read/28715518/early-accurate-diagnosis-and-early-intervention-in-cerebral-palsy-advances-in-diagnosis-and-treatment
#7
Iona Novak, Cathy Morgan, Lars Adde, James Blackman, Roslyn N Boyd, Janice Brunstrom-Hernandez, Giovanni Cioni, Diane Damiano, Johanna Darrah, Ann-Christin Eliasson, Linda S de Vries, Christa Einspieler, Michael Fahey, Darcy Fehlings, Donna M Ferriero, Linda Fetters, Simona Fiori, Hans Forssberg, Andrew M Gordon, Susan Greaves, Andrea Guzzetta, Mijna Hadders-Algra, Regina Harbourne, Angelina Kakooza-Mwesige, Petra Karlsson, Lena Krumlinde-Sundholm, Beatrice Latal, Alison Loughran-Fowlds, Nathalie Maitre, Sarah McIntyre, Garey Noritz, Lindsay Pennington, Domenico M Romeo, Roberta Shepherd, Alicia J Spittle, Marelle Thornton, Jane Valentine, Karen Walker, Robert White, Nadia Badawi
Importance: Cerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 months' corrected age. Objectives: To systematically review best available evidence for early, accurate diagnosis of cerebral palsy and to summarize best available evidence about cerebral palsy-specific early intervention that should follow early diagnosis to optimize neuroplasticity and function...
July 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28714607/new-insights-into-how-serotonin-selective-reuptake-inhibitors-shape-the-developing-brain
#8
REVIEW
Jay A Gingrich, Heli Malm, Mark S Ansorge, Alan Brown, Andre Sourander, Deepika Suri, Cátia M Teixeira, Martha K Caffrey Cagliostro, Darshini Mahadevia, Myrna M Weissman
Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system (CNS) development, such sensitive periods shape the formation of neuro-circuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint, as well as the environmental context. While allowing for adaptation, such sensitive periods are also windows of vulnerability during which external and internal factors can confer risk to brain disorders by derailing adaptive developmental programs...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28714396/differential-effects-of-nicotine-exposure-on-the-hippocampus-across-lifespan
#9
Dana Zeid, Munir Gunes Kutlu, Thomas J Gould
Nicotine exposure affects the hippocampus through activation of hippocampal nicotinic acetylcholine receptors (nAChRs), which are present throughout excitatory and inhibitory hippocampal circuitry. The role of cholinergic functioning in the hippocampus varies across developmental stages so that nicotine exposure differentially affects this region depending upon timing of exposure, producing developmentally distinct changes in structure, function, and behavior. The hippocampus continues to mature well into adolescence, and this development is modulated by cholinergic activity...
July 13, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28712652/serotonergic-modulation-enables-pathway-specific-plasticity-in-a-developing-sensory-circuit-in-drosophila
#10
Takuya Kaneko, Ann Marie Macara, Ruonan Li, Yujia Hu, Kenichi Iwasaki, Zane Dunnings, Ethan Firestone, Shawn Horvatic, Ananya Guntur, Orie T Shafer, Chung-Hui Yang, Jie Zhou, Bing Ye
How experiences during development cause long-lasting changes in sensory circuits and affect behavior in mature animals are poorly understood. Here we establish a novel system for mechanistic analysis of the plasticity of developing neural circuits by showing that sensory experience during development alters nociceptive behavior and circuit physiology in Drosophila larvae. Despite the convergence of nociceptive and mechanosensory inputs on common second-order neurons (SONs), developmental noxious input modifies transmission from nociceptors to their SONs, but not from mechanosensors to the same SONs, which suggests striking sensory pathway specificity...
July 8, 2017: Neuron
https://www.readbyqxmd.com/read/28706476/long-term-sex-dependent-vulnerability-to-metabolic-challenges-in-prenatally-stressed-rats
#11
Pamela Panetta, Alessandra Berry, Veronica Bellisario, Sara Capoccia, Carla Raggi, Alessia Luoni, Linda Longo, Marco A Riva, Francesca Cirulli
Prenatal stress (PNS) might affect the developmental programming of adult chronic diseases such as metabolic and mood disorders. The molecular mechanisms underlying such regulations may rely upon long-term changes in stress-responsive effectors such as Brain-Derived Neurotrophic Factor (BDNF) that can affect neuronal plasticity underlying mood disorders and may also play a role in metabolic regulation. Based upon previous data, we hypothesized that PNS might lead to greater vulnerability to an obesogenic challenge experienced at adulthood...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28706475/focal-stroke-in-the-developing-rat-motor-cortex-induces-age-and-experience-dependent-maladaptive-plasticity-of-corticospinal-system
#12
Mariangela Gennaro, Alessandro Mattiello, Raffaele Mazziotti, Camilla Antonelli, Lisa Gherardini, Andrea Guzzetta, Nicoletta Berardi, Giovanni Cioni, Tommaso Pizzorusso
Motor system development is characterized by an activity-dependent competition between ipsilateral and contralateral corticospinal tracts (CST). Clinical evidence suggests that age is crucial for developmental stroke outcome, with early lesions inducing a "maladaptive" strengthening of ipsilateral projections from the healthy hemisphere and worse motor impairment. Here, we investigated in developing rats the relation between lesion timing, motor outcome and CST remodeling pattern. We induced a focal ischemia into forelimb motor cortex (fM1) at two distinct pre-weaning ages: P14 and P21...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28701555/consistent-cooperation-in-a-cichlid-fish-is-caused-by-maternal-and-developmental-effects-rather-than-heritable-genetic-variation
#13
Claudia Kasper, Mathias Kölliker, Erik Postma, Barbara Taborsky
Studies on the evolution of cooperative behaviour are typically confined to understanding its adaptive value. It is equally essential, however, to understand its potential to evolve, requiring knowledge about the phenotypic consistency and genetic basis of cooperative behaviour. While previous observational studies reported considerably high heritabilities of helping behaviour in cooperatively breeding vertebrates, experimental studies disentangling the relevant genetic and non-genetic components of cooperative behaviour are lacking...
July 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28696432/cross-disorder-risk-gene-cacna1c-differentially-modulates-susceptibility-to-psychiatric-disorders-during-development-and-adulthood
#14
N Dedic, M L Pöhlmann, J S Richter, D Mehta, D Czamara, M W Metzger, J Dine, B T Bedenk, J Hartmann, K V Wagner, A Jurik, L M Almli, A Lori, S Moosmang, F Hofmann, C T Wotjak, G Rammes, M Eder, A Chen, K J Ressler, W Wurst, M V Schmidt, E B Binder, J M Deussing
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Cav1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. However, genetic variants of complex diseases often only confer a marginal increase in disease risk, which is additionally influenced by the environment. Here we show that embryonic deletion of Cacna1c in forebrain glutamatergic neurons promotes the manifestation of endophenotypes related to psychiatric disorders including cognitive decline, impaired synaptic plasticity, reduced sociability, hyperactivity and increased anxiety...
July 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28696428/growing-the-lost-crops-of-eastern-north-america-s-original-agricultural-system
#15
Natalie G Mueller, Gayle J Fritz, Paul Patton, Stephen Carmody, Elizabeth T Horton
Thousands of years before the maize-based agriculture practiced by many Native American societies in eastern North America at the time of contact with Europeans, there existed a unique crop system only known through archaeological evidence. There are no written or oral records of how these lost crops were cultivated, but several domesticated subspecies have been identified in the archaeological record. Growth experiments and observations of living progenitors of these crops can provide insights into the ancient agricultural system of eastern North America, the role of developmental plasticity in the process of domestication, and the creation and maintenance of diverse landraces under cultivation...
July 5, 2017: Nature Plants
https://www.readbyqxmd.com/read/28692904/emerging-roles-of-the-histone-chaperone-caf-1-in-cellular-plasticity
#16
REVIEW
Sihem Cheloufi, Konrad Hochedlinger
During embryonic development, cells become progressively restricted in their differentiation potential. This is thought to be regulated by dynamic changes in chromatin structure and associated modifications, which act together to stabilize distinct specialized cell lineages. Remarkably, differentiated cells can be experimentally reprogrammed to a stem cell-like state or to alternative lineages. Thus, cellular reprogramming provides a valuable platform to study the mechanisms that normally safeguard cell identity and uncover factors whose manipulation facilitates cell fate transitions...
July 7, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28689722/genetic-components-in-a-thermal-developmental-plasticity-of-the-beetle-tribolium-castaneum
#17
Marcin Czarnoleski, Paulina Kramarz, Dariusz Małek, Szymon M Drobniak
Low developmental temperatures cause ectotherms to retard growth, postpone maturation, and emerge at either larger or smaller adult size. In this study, we explored how these thermal responses evolved, focusing on their genetic basis. We applied a full diallel breeding design on inbred lines of the flour beetle, Tribolium castaneum. To assess the proportional contributions of genetic and non-genetic effects, each genotype, a unique combination of parental haplotypes, was reared from an egg to imago at five developmental temperatures...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28688903/differential-effects-between-developmental-and-postpubertal-exposure-to-n-methyl-n-nitrosourea-on-progenitor-cell-proliferation-of-rat-hippocampal-neurogenesis-in-relation-to-cox2-expression-in-granule-cells
#18
Yousuke Watanabe, Kota Nakajima, Sayaka Mizukami, Yumi Akahori, Nobuya Imatanaka, Gye-Hyeong Woo, Toshinori Yoshida, Makoto Shibutani
This study was performed to compare the exposure effects of N-methyl-N-nitrosourea (MNU), a cytocidal agent of proliferating cells, on rat hippocampal neurogenesis between developmental and postpubertal periods. Developmental exposure through maternal drinking water from gestational day 6 to day 21 after delivery on weaning decreased GFAP-immunoreactive ((+)) stem cells and increased immunoreactive cells indicative of subsequent progenitor and postmitotic immature neuronal populations, TUNEL(+) or p21(Cip1/Waf1+) stem/progenitor cells and COX2(+) granule cells, on postnatal day (PND) 21...
July 5, 2017: Toxicology
https://www.readbyqxmd.com/read/28688462/editorial-overview-developmental-mechanisms-patterning-and-evolution-developmental-patterning-from-stochasticity-to-plasticity
#19
EDITORIAL
Christian S Hardtke, Yoshiko Takahashi
No abstract text is available yet for this article.
August 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28686814/early-survival-and-delayed-death-of-developmentally-born-dentate-gyrus-neurons
#20
Shaina P Cahill, Ru Qi Yu, Dylan Green, Evgenia V Todorova, Jason S Snyder
The storage and persistence of memories depends on plasticity in the hippocampus. Adult neurogenesis produces new neurons that mature through critical periods for plasticity and cellular survival, which determine their contributions to learning and memory. However, most granule neurons are generated prior to adulthood; the maturational timecourse of these neurons is poorly understood compared to adult-born neurons, but is essential to identify how the dentate gyrus, as a whole, contributes to behavior. To characterize neurons born in the early postnatal period, we labeled dentate gyrus neurons born on postnatal day 6 (P6) with BrdU and quantified maturation and survival across early (1 hour to 8 weeks old) and late (2-6 months old) cell ages...
July 7, 2017: Hippocampus
keyword
keyword
2706
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"