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Borrelia burgdoferi

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https://www.readbyqxmd.com/read/26457476/in-vitro-evaluation-of-antibacterial-activity-of-phytochemicals-and-micronutrients-against-borrelia-burgdorferi-and-borrelia-garinii
#1
A Goc, A Niedzwiecki, M Rath
AIMS: Little is known about the effects of phytochemicals against Borrelia sp. causing Lyme disease. Current therapeutic approach to this disease is limited to antibiotics. This study examined the anti-borreliae efficacy of several plant-derived compounds and micronutrients. METHODS AND RESULTS: We tested the efficacy of 15 phytochemicals and micronutrients against three morphological forms of Borrelia burgdoferi and Borrelia garinii: spirochetes, latent rounded forms and biofilm...
December 2015: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/25890386/immunization-with-a-recombinant-subunit-ospa-vaccine-markedly-impacts-the-rate-of-newly-acquired-borrelia-burgdorferi-infections-in-client-owned-dogs-living-in-a-coastal-community-in-maine-usa
#2
Andrew K Eschner, Kristen Mugnai
BACKGROUND: In North America, Borrelia burgdorferi is the causative bacterial agent of canine Lyme borreliosis and is transmitted following prolonged attachment and feeding of vector ticks, Ixodes scapularis or Ixodes pacificus. Its prevention is predicated upon tick-avoidance, effective on-animal tick control and effective immunization strategies. The purpose of this study is to characterize dogs that are newly seropositive for Borrelia burgdorferi infection in relation to compliant use of a recombinant OspA canine Lyme borreliosis vaccine...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25779233/immunization-with-a-recombinant-subunit-ospa-vaccine-markedly-impacts-the-rate-of-newly-acquired-borrelia-burgdorferi-infections-in-client-owned-dogs-living-in-a-coastal-community-in-maine-usa
#3
Andrew K Eschner, Kristen Mugnai
BACKGROUND: In North America, Borrelia burgdorferi is the causative bacterial agent of canine Lyme borreliosis and is transmitted following prolonged attachment and feeding of vector ticks, Ixodes scapularis or Ixodes pacificus. Its prevention is predicated upon tick-avoidance, effective on-animal tick control and effective immunization strategies. The purpose of this study is to characterize dogs that are newly seropositive for Borrelia burgdorferi infection in relation to compliant use of a recombinant OspA canine Lyme borreliosis vaccine...
December 2015: Parasites & Vectors
https://www.readbyqxmd.com/read/24698204/-lyme-disease-acrodermitis-chronica-atrophicans-misleading-vascular-signs
#4
S Blaise, G Fiandrino, B Satger, P-H Carpentier
Lyme disease acrodermatitis chronica atrophicans is a tertiary form of Lyme borrelliosis. It occurs at least six months, but also up to several years, after a tick bite. This rare condition is probably underestimated because of the difficult diagnosis. Clinical presentations of acrodermatitis chronic atrophicans are quite variable depending upon the duration of the disease. Complimentary explorations are difficult to interpret and rarely specific. Only rare configurations allow formal diagnosis of Borrelia burgdoferi infection...
May 2014: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/22665558/protracted-neuroborreliosis-an-unusual-cause-of-encephalomyelitis
#5
Saif Huda, Udo Carl Wieshmann
A 58-year-old lady with waxing and waning of non-specific symptoms including fatigue, dizziness, hearing loss and unsteady gait for 15 months, became acutely confused 12 h prior to presentation. On admission to a district hospital she was feverish and unresponsive. Her travel history consisted of visits to Argentina, Chile and the Outer Hebrides. CT of the brain was normal. Lumbar puncture demonstrated a lymphocytic pleocytosis of 500 cells, protein of 1 g/l, a low glucose ratio with negative cytology and viral PCR (including herpes simplex 1 and 2)...
2012: BMJ Case Reports
https://www.readbyqxmd.com/read/21217171/the-lyme-disease-vaccine-a-public-health-perspective
#6
REVIEW
Angela K Shen, Paul S Mead, Charles B Beard
Lyme disease, which is caused by the spirochetal agent Borrelia burgdoferi, is the most common vector-borne illness in the United States. In 1998, the US Food and Drug Administration approved a recombinant Lyme disease vaccine that was later voluntarily withdrawn from the market by the manufacturer. Current Lyme disease prevention efforts focus on a combination of methods and approaches, including area acaricides, landscape management, host-targeted interventions, management of deer populations, and personal protective measures, such as the use of insect repellant and tick checks...
February 2011: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/19899616/the-first-detection-of-babesia-eu1-and-babesia-canis-canis-in-ixodes-ricinus-ticks-acari-ixodidae-collected-in-urban-and-rural-areas-in-northern-poland
#7
Stella Cieniuch, Joanna Stańczak, Anna Ruczaj
Ixodes ricinus, the most commonly observed tick species in Poland, is a known vector of such pathogenic microorganisms as TBE viruses, Borrelia burgdoferi sensu lato, Anaplasma phagocytophilum, Rickettsia helvetica, Babesia divergens and B. microti in our country. Our study aimed to find out whether this tick can also transmit other babesiae of medical and veterinary importance. DNA extracts of 1392 ticks (314 nymphs, 552 male and 526 female ticks) collected in urban and rural areas in the Pomerania province (northern Poland), were examined by nested PCR for the detection of Babesia spp...
2009: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/19757556/efficacy-of-a-nonadjuvanted-outer-surface-protein-a-recombinant-vaccine-in-dogs-after-challenge-by-ticks-naturally-infected-with-borrelia-burgdorferi
#8
RANDOMIZED CONTROLLED TRIAL
J A Conlon, T N Mather, P Tanner, G Gallo, R H Jacobson
In a blinded, controlled study, thirty purpose-bred, Borrelia burgdorferi negative, mixed-breed dogs 10 to 12 weeks of age were randomly divided into three groups of ten animals each for the purpose of evaluating a recombinant nonadjuvanted B. burgdorferi OspA vaccine (Recombitek Lyme [Merial Limited]) for efficacy and safety. Two groups received two doses of two different lots ofa nonadjuvanted, OspA, recombinant vaccine; the third group served as nonvaccinated controls. All dogs were challenged 3 weeks after the second vaccination with blacklegged deer ticks (Ixodes scapularis) harvested from a B...
2000: Veterinary Therapeutics: Research in Applied Veterinary Medicine
https://www.readbyqxmd.com/read/19635150/scleroderma-linearis-hemiatrophia-faciei-progressiva-parry-romberg-syndrom-without-any-changes-in-cns-and-linear-scleroderma-en-coup-de-sabre-with-cns-tumor
#9
Beata Bergler-Czop, Anna Lis-Swiety, Ligia Brzezińska-Wcisło
BACKGROUND: Hemifacial atrophy (Parry-Romberg syndrome) is a relatively rare disease. The etiology of the disease is not clear. Some authors postulate its relation with limited scleroderma linearis. Linear scleroderma "en coup de sabre" is characterized by clinical presence of most commonly one-sided linear syndrome. In a number of patients, neurological affection is the medium of the disease. The treatment of both scleroderma varieties is similar to the treatment of limited systemic sclerosis...
2009: BMC Neurology
https://www.readbyqxmd.com/read/19591790/bioinformatic-comparison-of-bacterial-secretomes
#10
COMPARATIVE STUDY
Catharine Song, Aseem Kumar, Mazen Saleh
The rapid increasing number of completed bacterial genomes provides a good opportunity to compare their proteomes. This study was undertaken to specifically compare and contrast their secretomes-the fraction of the proteome with predicted N-terminal signal sequences, both type I and type II. A total of 176 theoretical bacterial proteomes were examined using the ExProt program. Compared with the Gram-positives, the Gram-negative bacteria were found, on average, to contain a larger number of potential Sec-dependent sequences...
June 2009: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/19499997/characterization-of-borrelia-burgdorferi-aggregates
#11
Siddharth Y Srivastava, Aravinda M de Silva
Lyme disease is caused by the tick-borne spirochete, Borrelia burgdorferi. It has been documented that B. burgdorferi form aggregates within ticks and during in vitro culture. However, Borrelia aggregates remain poorly characterized, and their functional significance is unknown. Here we have characterized Borrelia aggregates using microscopy and flow cytometry. Borrelia aggregation was temperature, pH, and growth phase dependent. Environmental conditions (high temperature, low pH, and high cell density) favorable for aggregation were similar to the conditions that increased the expression of B...
June 2009: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/19253089/laboratory-data-in-children-with-lyme-neuroborreliosis-relation-to-clinical-presentation-and-duration-of-symptoms
#12
COMPARATIVE STUDY
Dag Tveitnes, Knut Øymar, Olav Natås
The occurrence of IgM and IgG antibodies against Borrelia burgdoferi in serum and cerebrospinal fluid (CSF) and intrathecal synthesis of antibodies (antibody index) were studied in relation to clinical presentation and the duration of symptoms before diagnosis in 146 children diagnosed with neuroborreliosis. Lymphocytic meningitis was demonstrated in 141 of these children. Levels of white blood cells (WBC) and protein in CSF correlated significantly to numbers of d with symptoms. Children were divided into 3 clinical groups: A (n = 37): only cranial neuropathy; B (n = 68): both cranial neuropathy and other neurological symptoms; C (n = 41): neurological symptoms without cranial neuropathy...
2009: Scandinavian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/17585546/-risk-for-infection-by-lyme-disease-cause-in-green-surfaces-maintenance-workers-in-belgrade
#13
Milena Krstić, Novica Stajković
BACKGROUND/AIM: Lyme disease (LD) is a cosmopolitan disease from the group of zoonoses that in humans can affect skins, joints, heart and/or nervous system. Research conducted in endemic areas, shows not only that the population, which lives or works in tick habitats, is in a high risk for getting infected by LD cause, but also that every enviroment itself is specific in regard to both vectors and B. burgdoferi species. In our enviroment, research of seropositivity to B. bugdorferi in persons exposed to vectors of LD have not been conducted...
May 2007: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/17026839/in-vitro-susceptibility-of-isolates-of-borrelia-burgdorferi-s-l-to-antimicrobial-agents
#14
I Santino, F Scazzocchio, L Ciceroni, S Ciarrocchi, R Sessa, M Del Piano
In the present study, we investigate the in vitro antimicrobial activity of macrolides, beta-lactams and tetracycline against Borrelia burgdorferi s.l. clinical and tick isolates. Minimal inhibitory concentrations (MICs) were determined in normal growth condition and after pre-exposure of the strains to sub-MIC of the founder of each drug family. All the classes of tested antibiotics showed good antibacterial activity against all the borreliae isolates and there were no significant susceptibility differences among clinical and tick isolates...
July 2006: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/16995409/transfer-of-borrelia-burgdorferi-s-s-infection-via-blood-transfusion-in-a-murine-model
#15
Elizabeth S Gabitzsch, Joseph Piesman, Marc C Dolan, Christine M Sykes, Nordin S Zeidner
Without antibiotic treatment, the Lyme-disease-causing bacterium, Borrelia burgdorferi can be cultured from the peripheral blood of human patients nearly 6 wk post-tick bite. To determine if Lyme disease spirochetes can be transmitted from a spirochetemic donor mouse to a naive recipient during blood transfusion, blood taken from immunocompetent infected mice was transfused into either immunodeficient (SCID) mice, inbred immunocompetent animals (C3H/HeJ), or outbred mice. Nine of 19 (47.7%) immunodeficient mice, 7 of 15 (46...
August 2006: Journal of Parasitology
https://www.readbyqxmd.com/read/16619623/an-avian-contribution-to-the-presence-of-ixodes-pacificus-acari-ixodidae-and-borrelia-burgdorferi-on-the-sutter-buttes-of-california
#16
COMPARATIVE STUDY
Stan A Wright, Debbie A Lemenager, James R Tucker, M Veronica Armijos, Sheryl A Yamamoto
Birds from 45 species were sampled during three spring seasons from an isolated canyon on the Sutter Buttes in California for the presence of subadult stages of Ixodes pacificus Cooley & Kohls, and for infection with Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt & Brenner. These birds were found to have an infestation prevalence of 45%, a density of 1.7 ticks per bird, and an intensity of 3.8 ticks per infested bird. There was a significant difference in the I. pacificus infestations between canopy and ground-dwelling birds...
March 2006: Journal of Medical Entomology
https://www.readbyqxmd.com/read/15500628/characterization-of-the-b-cell-inhibitory-protein-factor-in-ixodes-ricinus-tick-saliva-a-potential-role-in-enhanced-borrelia-burgdoferi-transmission
#17
Sigrid Hannier, Janet Liversidge, Jeremy M Sternberg, Alan S Bowman
We recently described the inhibition of host B lymphocytes by Ixodes ricinus tick saliva. In this study, we characterized the factor responsible for this activity and examined the modulation of lipopolysaccharide (LPS)- and Borrelia burgdorferi outer surface protein (Osp)-induced proliferation of naive murine B lymphocytes by an enriched fraction of this factor. The B-lymphocyte inhibitory activity was destroyed by trypsin treatment, indicating that a proteinaceous factor was responsible for this activity. The removal of glutathione-S-transferase (GST) from tick salivary glands extracts (SGE) showed that this B-cell inhibitory protein (BIP) was not a GST...
November 2004: Immunology
https://www.readbyqxmd.com/read/15305698/-ticks-and-the-pediatrician
#18
REVIEW
P Occorsio, G Orso, L di Martino
The match between ticks and pediatricians in Italy is usually a seasonal event related to the spring and summer trips and to the increasing of outdoor activity that sun and warm weather allow, both for children and ticks. So cared parents reach emergencies asking for tick removal but more often after the tick has yet been removed by empirical manoeuvres and after the killing and the destruction of the "enemy". We have scheduled, in the years 2002-2003, the 167 children that reached our unit for a tick bite; they where 92 males (mean age four years) and 75 females (mean age five years)...
June 2004: Parassitologia
https://www.readbyqxmd.com/read/15060815/isolated-monolateral-neurosensory-hearing-loss-as-a-rare-sign-of-neuroborreliosis
#19
I Iero, M Elia, F I I Cosentino, B Lanuzza, R S Spada, G Toscano, M Tripodi, A Belfiore, R Ferri
Lyme disease, or borreliosis, is a zoonosis transmitted by Borrelia burgdorferi which also involves the central nervous system (CNS), in 15% of affected individuals, with the occurrence of aseptic meningitis, fluctuating meningoencephalitis, or neuropathy of cranial and peripheral nerves. Encephalopathy with white matter lesions revealed by magnetic resonance imaging (MRI) scans in late, persistent stages of Lyme disease has been described. In this report, we describe a patient with few clinical manifestations involving exclusively the eighth cranial nerve, monolaterally and diffuse bilateral alterations of the white matter, particularly in the subcortical periventricular regions at cerebral MRI...
April 2004: Neurological Sciences
https://www.readbyqxmd.com/read/11558789/central-and-peripheral-nervous-system-infection-immunity-and-inflammation-in-the-nhp-model-of-lyme-borreliosis
#20
A R Pachner, D Cadavid, G Shu, D Dail, S Pachner, E Hodzic, S W Barthold
The relationship between chronic infection, antispirochetal immunity, and inflammation is unknown in Lyme neuroborreliosis. In the nonhuman primate model of Lyme neuroborreliosis, we measured spirochetal density in the nervous system and other tissues by polymerase chain reaction and correlated these values to anti-Borrelia burgdorferi antibody in the serum and cerebrospinal fluid, and to inflammation in tissues. Despite substantial presence of Borrelia burgdorferi, the causative agent of Lyme borreliosis, in the central nervous system, only minor inflammation was present there, though skeletal and cardiac muscle, which contained similar levels of spirochete, were highly inflamed...
September 2001: Annals of Neurology
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