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https://www.readbyqxmd.com/read/28443086/complete-molecular-and-immunoprotective-characterization-of-babesia-microti-enolase
#1
Xiangye Liu, Chen Zheng, Xiaoge Gao, Jiaxu Chen, Kuiyang Zheng
The apicomplexan Babesia microti is the primary causative agent of human babesiosis, one of the most broadly distributed tick-borne diseases worldwide. B. microti undergoes a complex lifecycle within both the mammalian host and the tick vector, and employs several different specific molecular mechanisms to enter host cells. Enolase, the key glycolytic enzyme in intracellular glucose metabolism, can also be expressed on the parasite's outer surface, binds to human plasminogen, and coordinates apicomplexan parasite invasion of host cells, however, it lacks sorting sequences or lipoprotein anchor sites...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28438201/relation-of-antioxidant-status-at-admission-and-disease-severity-and-outcome-in-dogs-naturally-infected-with-babesia-canis-canis
#2
Martina Crnogaj, José Joaquin Cerón, Iva Šmit, Ivana Kiš, Jelena Gotić, Mirna Brkljačić, Vesna Matijatko, Camila Peres Rubio, Nada Kučer, Vladimir Mrljak
BACKGROUND: Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors' knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes...
April 24, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28435891/detection-of-anaplasma-phagocytophilum-babesia-microti-borrelia-burgdorferi-borrelia-miyamotoi-and-powassan-virus-in-ticks-by-a-multiplex-real-time-reverse-transcription-pcr-assay
#3
Rafal Tokarz, Teresa Tagliafierro, D Moses Cucura, Ilia Rochlin, Stephen Sameroff, W Ian Lipkin
Ixodes scapularis ticks are implicated in transmission of Anaplasma phagocytophilum, Borrelia burgdorferi, Borrelia miyamotoi, Babesia microti, and Powassan virus. We describe the establishment and implementation of the first multiplex real-time PCR assay with the capability to simultaneously detect and differentiate all five pathogens in a single reaction. The application of this assay for analysis of ticks at sites in New York and Connecticut revealed a high prevalence of B. microti in ticks from Suffolk County, NY...
March 2017: MSphere
https://www.readbyqxmd.com/read/28427963/molecular-investigation-of-piroplasma-infection-in-white-yaks-bos-grunniens-in-gansu-province-china
#4
Sitong Li, Junlong Liu, Aihong Liu, Youquan Li, Shuqing Wang, Shufang Wang, Hong Yin, Jianxun Luo, Guiquan Guan
Piroplasmosis, including theileriosis and babesiosis, is a tick-borne haemoprotozoan disease responsible for huge economic losses to livestock industry. In China, the biology of piroplasms infective to cattle was well understood on the basis of pathogen isolations and molecular epidemiological surveys in the past few decades. But very limited information about the infection status of piroplasms in white yak (Bos grunniens), a semi-wild and endemic breed, has been recorded, so far. A total of 350 blood samples was collected from white yaks in 11 towns of Tianzhu Tibetan Autonomous County of Gansu province, China, during April to July 2015...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28416183/inhibition-of-the-in-vitro-growth-of-babesia-bigemina-babesia-caballi-and-theileria-equi-parasites-by-trifluralin-analogues
#5
Marta G Silva, Donald P Knowles, Sandra Antunes, Ana Domingos, Maria A Esteves, Carlos E Suarez
Bovine and equine babesiosis caused by Babesia bovis, Babesia bigemina and Babesia caballi, along with equine theileriosis caused by Theileria equi are global tick-borne hemoprotozoan diseases characterized by fever, anemia, weight losses and abortions. A common feature of these diseases are transition from acute to chronic phases, in which parasites may persist in the hosts for life. Antiprotozoal drugs are important for managing infection and disease. Previous research demonstrated that trifluralin analogues, designated (TFLAs) 1-15, which specifically bind to regions of alpha-tubulin protein in plants and protozoan parasites, have the ability to inhibit the in vitro growth of B...
April 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28413078/evaluation-of-immunochromatographic-test-ict-strips-for-the-serological-detection-of-babesia-bovis-and-babesia-bigemina-infection-in-cattle-from-western-java-indonesia
#6
Azirwan Guswanto, Puttik Allamanda, Euis Siti Mariamah, Tserendorf Munkjargal, Bumduuren Tuvshintulga, Hitoshi Takemae, Thillaiampalam Sivakumar, Mahmoud AbouLaila, Mohamad Alaa Terkawi, Madoka Ichikawa-Seki, Yoshifumi Nishikawa, Naoaki Yokoyama, Ikuo Igarashi
Three types of immunochromatographic test (ICT) strips were prepared for the detection of an antibody response against spherical body protein 4 (SBP-4) of Babesia bovis (bovICT), C-terminal-truncated rhoptry-associated protein 1 (rRAP1/CT17) of B. bigemina (bigICT), and the combination of both proteins (dual-ICT). The evaluation of their performance was conducted using a confirmed positive and negative serum panel for B. bovis and B. bigemina. Together with ELISA, the ICT strips were applied to determine the seroprevalence of bovine babesiosis in Western Java, Indonesia...
April 10, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28410591/eurasian-golden-jackal-as-host-of-canine-vector-borne-protists
#7
Barbora Mitková, Kristýna Hrazdilová, Gianluca D'Amico, Georg Gerhard Duscher, Franz Suchentrunk, Pavel Forejtek, Călin Mircea Gherman, Ioana Adriana Matei, Angela Monica Ionică, Aikaterini Alexandra Daskalaki, Andrei Daniel Mihalca, Jan Votýpka, Pavel Hulva, David Modrý
BACKGROUND: Jackals are medium-sized canids from the wolf-like clade, exhibiting a unique combination of ancestral morphotypes, broad trophic niches, and close phylogenetic relationships with the wolf and dog. Thus, they represent a potential host of several pathogens with diverse transmission routes. Recently, populations of the Eurasian golden jackal Canis aureus have expanded into the Western Palaearctic, including most of Europe. The aim of our study was to examine Eurasian golden jackals from Romania, Czech Republic and Austria for a wide spectrum of vector-borne protists and to evaluate the role of this species as a reservoir of disease for domestic dogs and/or humans...
April 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28408215/prevalence-genetic-diversity-and-potential-clinical-impact-of-blood-borne-and-enteric-protozoan-parasites-in-native-mammals-from-northern-australia
#8
Amanda Barbosa, Andrea Reiss, Bethany Jackson, Kristin Warren, Andrea Paparini, Graeme Gillespie, Danielle Stokeld, Peter Irwin, Una Ryan
A molecular survey was conducted to provide baseline information on the prevalence, genetic diversity and potential clinical impacts of blood-borne and enteric protozoans in native wild mammals from the Northern Territory (NT). A total of 209 blood and 167 faecal samples were collected from four target species; the northern brown bandicoot (Isoodon macrourus), common brushtail possum (Trichosurus vulpecula), northern quoll (Dasyurus hallucatus) and brush-tailed rabbit-rat (Conilurus penicillatus). Blood samples were screened by PCR at the 18S rRNA gene for trypanosomes, piroplasms and haemogregarines, with faecal samples tested for Cryptosporidium spp...
April 4, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28405337/autoimmune-hemolytic-anemia-associated-with-babesiosis
#9
Roshni Narurkar, Aleksandra Mamorska-Dyga, John C Nelson, Delong Liu
BACKGROUND: Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is known to be caused by parasitic and viral infections but has not been well characterized. CASE PRESENTATION: We describe two cases diagnosed with babesiosis triggering severe AIHA. One case had history of splenectomy, and the other was an elderly patient...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28399851/babesiosis-in-long-island-review-of-62-cases-focusing-on-treatment-with-azithromycin-and-atovaquone
#10
Ekaterina A Kletsova, Eric D Spitzer, Bettina C Fries, Luis A Marcos
BACKGROUND: Babesiosis is a potentially life-threatening, tick-borne infection endemic in New York. The purpose of this study was to review recent trends in babesiosis management and outcomes focusing on patients, who were treated with combination of azithromycin and atovaquone. METHODS: A retrospective chart review of patients seen at Stony Brook University Hospital between 2008 and 2014 with peripheral blood smears positive for Babesia was performed. Clinical and epidemiological information was recorded and analyzed...
April 11, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28392045/low-prevalence-of-zoonotic-babesia-in-small-mammals-and-ixodes-ricinus-in-brittany-france
#11
M Jouglin, G Perez, A Butet, L Malandrin, S Bastian
In order to evaluate the zoonotic risk due to Babesia spp., especially B. microti, we investigated their presence in 597 individuals of five small mammal species and in 2620 questing nymphs of Ixodes ricinus in rural landscapes of Western France (Brittany). Small mammals (rodents and shrews) are indeed suspected to be reservoir hosts for B. microti, and the tick I. ricinus is the vector of the three main zoonotic species in Europe, i.e. B. divergens, B. venatorum and B. microti. Only one bank vole carried B...
March 25, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28378977/prevalence-of-infections-and-co-infections-with-6-pathogens-in-dermacentor-reticulatus-ticks-collected-in-eastern-poland
#12
Violetta Zając, Angelina Wójcik-Fatla, Anna Sawczyn, Ewa Cisak, Jacek Sroka, Anna Kloc, Zbigniew Zając, Alicja Buczek, Jacek Dutkiewicz, Katarzyna Bartosik
Occurrence of co-infections with various pathogens in ixodid ticks creates a risk of increased severity of tick-borne diseases in humans and animals exposed to bite of the ticks carrying multiple pathogens. Accordingly, co-infections in ticks were subject of numerous analyses, but almost exclusively with regard to Ixodes ricinus complex whereas potential tick vectors belonging to other genera were much less studied. Taking into consideration the role of Dermacentor reticulatus in the transmission of various pathogens, we carried out for the first time the comprehensive statistical analysis of co-infections occurring in this tick species...
March 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28376903/the-prevalence-and-impact-of-babesia-canis-and-theileria-sp-in-free-ranging-grey-wolf-canis-lupus-populations-in-croatia
#13
Ana Beck, Doroteja Huber, Adam Polkinghorne, Andrea Gudan Kurilj, Valerija Benko, Vladimir Mrljak, Slaven Reljić, Josip Kusak, Irena Reil, Relja Beck
BACKGROUND: Babesia spp. and Theileria spp. are important emerging causes of disease in dogs. Alongside these domesticated hosts, there is increasing recognition that these piroplasms can also be found in a range of wild animals with isolated reports describing the presence of these pathogen in foxes (Vulpes vulpes) and captive grey wolves (Canis lupus). The prevalence and impact of these infections in free-ranging populations of canids are unknown. To gain a better insight into the epidemiology and pathogenesis of piroplasm infections in free-ranging grey wolves, pathological and molecular investigations into captive and free-ranging grey wolves in Croatia were performed...
April 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28363279/blood-markers-of-fibrinolysis-and-endothelial-activation-in-canine-babesiosis
#14
Josipa Kuleš, Jelena Gotić, Vladimir Mrljak, Renata Barić Rafaj
BACKGROUND: Canine babesiosis is a tick-borne disease caused by hemoprotozoan parasites of the genus Babesia. The disease can be clinically classified into uncomplicated and complicated forms. The aim of this study was to assess the level of endothelial activation and alterations in the fibrinolytic pathway during canine babesiosis. RESULTS: Blood samples were collected on the day of admission and on the 6th day after treatment with imidocarb propionate, from 30 dogs of various breeds and of both sexes with naturally occurring babesiosis caused by B...
March 31, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28361802/molecular-characterization-of-babesia-and-theileria-species-in-ticks-collected-in-the-outskirt-of-monte-romano-lazio-region-central-italy
#15
Luciano Toma, Marco Di Luca, Fabiola Mancini, Francesco Severini, Carmela Mariano, Giancarlo Nicolai, Valentina Laghezza Masci, Alessandra Ciervo, Anna Maria Fausto, Simone Mario Cacciò
BACKGROUND: In 2012-2013, an investigation was carried out in the Viterbo province, Lazio region, on ticks and tick-borne Apicomplexan protozoa of the Babesia and Theileria genera. This followed the reporting of high density of ticks by soldiers operating in a military shooting range, and the signaling by owners and local veterinary authorities of several cases of babesiosis among cattle. METHODS: A total of 422 ticks were collected from 35 heads, whereas 96 ticks were collected by dragging...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28355109/identification-of-12-piroplasms-infecting-ten-tick-species-in-china-using-reverse-line-blot-hybridization
#16
Mirza Omar Abdallah, Qingli Niu, Jifei Yang, Muhammad Adeel Hassan, Peifa Yu, Guiquan Guan, Ze Chen, Guangyuan Liu, Jianxun Luo, Hong Yin
Piroplasmosis, a disease of domestic and wild animals is caused by tick-borne protozoa in the genera of Theileria and Babesia. There was limited information available about the prevalence of piroplasmosis in ticks in China. To assess potential threat of piroplasmosis in China, we investigated the infections of ovine and bovine Babesia and Theileria species in ticks collected from cattle, yaks, sheep, horses and camels in several regions of China where tick-borne diseases have been reported. A total of 652 ticks were collected from the animals in 6 provinces of China...
March 13, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28352260/a-molecular-survey-of-babesia-species-and-detection-of-a-new-babesia-species-by-dna-related-to-b-venatorum-from-white-yaks-in-tianzhu-china
#17
Junlong Liu, Guiquan Guan, Youquan Li, Aihong Liu, Jianxun Luo, Hong Yin
Bovine babesiosis is a tick-transmitted disease caused by different species of Babesia. The white yak is a unique yak breed that lives only in Tianzhu in the Tibetan Autonomous County, Gansu Province, in northwestern China. Previous research using the ELISA method has confirmed that the white yak could become infected with B. bigemina. The objective of this study was the molecular detection and identification of Babesia species in white yaks. A total of 409 white yak blood samples were collected from 11 areas of the Tianzhu Tibetan Autonomous County in Northwest China from April to August, 2015...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28351721/a-rapid-simple-and-sensitive-loop-mediated-isothermal-amplification-method-to-detect-anaplasma-bovis-in-sheep-and-goats-samples
#18
Jinhong Wang, Yan Zhang, Yanyan Cui, Yaqun Yan, Xiaoxing Wang, Rongjun Wang, Fuchun Jian, Longxian Zhang, Changshen Ning
A loop-mediated isothermal amplification (LAMP) technique has been widely used in detecting the nucleic acid of various pathogenic bacteria. In this study, a set of four LAMP primers was designed to specifically test Anaplasma bovis. The LAMP assay was performed at 62°C for 60min in a water bath. The specificity was confirmed by amplifying A. bovis isolate, while no cross reaction was observed with other five pathogens (Anaplasma bovis, Anaplasma phagocytophilum, Theileria luwenshuni, Babesia motasi and Schistosoma japonicum)...
March 25, 2017: Parasitology International
https://www.readbyqxmd.com/read/28335825/canine-tick-borne-diseases-in-pet-dogs-from-romania
#19
Martin O Andersson, Conny Tolf, Paula Tamba, Mircea Stefanache, Jonas Waldenström, Gerhard Dobler, Lidia Chițimia-Dobler
BACKGROUND: Tick-borne diseases are of substantial concern worldwide for animals as well as humans. Dogs have been a human companion for millennia, and their significant impact on human life renders disease in dogs to be of great concern. Tick-borne diseases in dogs represent a substantial diagnostic challenge for veterinarians in that clinical signs are often diffuse and overlapping. In addition, co-infections with two or more pathogens enhance this problem further. Molecular methods are useful to disentangle co-infections and to accurately describe prevalence and geographical distribution of tick-borne diseases...
March 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28329282/possible-transfusion-transmitted-babesia-divergens-like-mo-1-in-an-arkansas-patient
#20
Mary J Burgess, Eric R Rosenbaum, Bobbi S Pritt, Dirk T Haselow, Katie M Ferren, Bashar N Alzghoul, Juan Carlos Rico, Lynne M Sloan, Poornima Ramanan, Raghunandan Purushothaman, Robert W Bradsher
A patient with asplenia and multiple red blood cell transfusions acquired babesiosis infection with Babesia divergens-like/MO-1 and not Babesia microti, the common United States species. He had no known tick exposure. This is believed to be the first transfusion-transmitted case and the fifth documented case of Babesia divergens-like/MO-1.
March 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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