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Probiotic AND METABOLISM

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https://www.readbyqxmd.com/read/29777696/sterilized-bifidobacteria-suppressed-fat-accumulation-and-blood-glucose-level
#1
Keita Kikuchi, Mahmoud Ben Othman, Kazuichi Sakamoto
Probiotics such as Lactobacillus and Bifidobacterium improve the balance of intestinal microflora and have various physiological functions beneficial to human health. It is not always known whether the ingested microbial cells are viable- or killed. However, even sterilized bacterial cells are functional. Bacterial cell functions are strain-specific and their modes of action are still poorly understood. The aim of this study was to elucidate the roles of sterilized bifidobacteria in obesity and lipid metabolism...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29773467/human-microbiome-restoration-and-safety
#2
REVIEW
Eric Banan-Mwine Daliri, Charles Nkufi Tango, Byong H Lee, Deog-Hwan Oh
The human gut microbiome consists of many bacteria which are in symbiotic relationship with human beings. The gut microbial metabolism, as well as the microbial-host co-metabolism, has been found to greatly influence health and disease. Factors such as diet, antibiotic use and lifestyle have been associated with alterations in the gut microbial community and may result in several pathological conditions. For this reason, several strategies including fecal microbiota transplant and probiotic administration have been applied and proven to be feasible and effective in restoring the gut microbiota in humans...
May 9, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29771345/sucrose-metabolism-alters-lactobacillus-plantarum-survival-and-interactions-with-the-microbiota-in-the-digestive-tract
#3
Xiaochen Yin, Dustin D Heeney, Yanin Tab Srisengfa, Shin-Yu Chen, Carolyn M Slupsky, Maria L Marco
We investigated whether sucrose metabolism by probiotic Lactobacillus plantarum influences the intestinal survival and microbial responses to this organism when administered to mice fed a sucrose-rich, Western diet. A L. plantarum mutant unable to metabolize sucrose was constructed by deleting scrB, coding for beta-fructofuranosidase, in a rifampicin-resistant strain of L. plantarum NCIMB8826. The ScrB deficient mutant survived in 8-fold higher numbers compared to the wild-type strain when measured 24 h after administration on two consecutive days...
May 16, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29769003/influence-of-probiotics-on-dietary-protein-digestion-and-utilization-in-the-gastrointestinal-tract
#4
Jing Wang, Haifeng Ji
Protein is essential to growth and metabolism. Many factors influence dietary protein digestion and utilization in the gastrointestinal tract. Probiotics have attracted increasing attention in recent years owing to their broad health benefits, which may include a positive influence on the digestion and utilization of proteins. Several observations support their potential role in protein digestion. For example, probiotics can regulate the intestinal microflora and thereby influence intestinal bacteria related to proteolysis...
May 16, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29767727/effects-of-long-term-intake-of-a-yogurt-fermented-with-lactobacillus-delbrueckii-subsp-bulgaricus-2038-and-streptococcus-thermophilus-1131-on-mice
#5
Yuki Usui, Yasumasa Kimura, Takeshi Satoh, Naoki Takemura, Yasuo Ouchi, Hiroko Ohmiya, Kyosuke Kobayashi, Hiromi Suzuki, Satomi Koyama, Satoko Hagiwara, Hirotoshi Tanaka, Seiya Imoto, Gérard Eberl, Yukio Asami, Kosuke Fujimoto, Satoshi Uematsu
The gut is an extremely complicated ecosystem where microorganisms, nutrients and host cells interact vigorously. Although the function of the intestine and its barrier system weakens with age, some probiotics can potentially prevent age-related intestinal dysfunction. Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131, which are the constituents of LB81 yogurt, are representative probiotics. However, it is unclear whether their long-term intake has a beneficial influence on systemic function...
May 15, 2018: International Immunology
https://www.readbyqxmd.com/read/29765460/the-role-of-intestinal-microbiota-in-the-pathogenesis-of-nafld-starting-points-for-intervention
#6
Umberto Vespasiani-Gentilucci, Paolo Gallo, Antonio Picardi
In recent years, close links between intestinal microbiota and host metabolism have been recognized. Intestinal bacteria can participate in the extraction of calories from food, and circulation of bacterial products, in particular lipopolysaccharides (LPS), is responsible for the "metabolic endotoxemia", which contributes to insulin resistance and its complications, such as non-alcoholic fatty liver disease (NAFLD). Indeed, qualitative and quantitative intestinal dysbiotic changes have been clearly documented in NAFLD patients, and several mechanisms by which the intestinal microbiota can directly promote liver fat deposition, inflammation and fibrosis have also been described...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29758485/isolation-characterization-and-strain-selection-of-a-paenibacillus-species-for-use-as-a-probiotic-to-aid-in-ruminal-methane-mitigation-nitrate-nitrite-detoxification-and-food-safety
#7
Elizabeth A Latham, William E Pinchak, Julian Trachsel, Heather K Allen, Todd R Callaway, David J Nisbet, Robin C Anderson
The effects of dietary nitrate and Paenibacillus 79R4 (79R4), a denitrifying bacterium, when co-administered as a probiotic, on methane emissions, nitrate and nitrite-metabolizing capacity and fermentation characteristics were studied in vitro. Mixed populations of rumen microbes inoculated with 79R4 metabolized all levels of nitrite studied after 24 h in vitro incubation. Results from in vitro simulations resulted in up to 2 log10 colony forming unit reductions in E. coli O157:H7 and Campylobacter jejuni when these were co-cultured with 79R4...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29755604/probiotics-strains-modulate-gut-microbiota-and-lipid-metabolism-in-mule-ducks
#8
Maxime Even, Stéphane Davail, Mikael Rey, Annabelle Tavernier, Marianne Houssier, Marie Dominique Bernadet, Karine Gontier, Géraldine Pascal, Karine Ricaud
Background: Livestock production should respond to societal, environmental and economic changes. Since 2006 and the ban on antibiotics as growth factors in European Union, the use of probiotics has become widespread and has demonstrated the effect of intestinal microbiota on the performance of farm animals. Objective: The aim of this study was to investigate the effect of supplementation with Lactobacillus salivarius (as a probiotics strain or combined with other strains) on zootechnical performance, metabolic and immune gene expression and intestinal microbiota diversity in mule ducks using high-throughput sequencing and real-time PCR...
2018: Open Microbiology Journal
https://www.readbyqxmd.com/read/29751655/a-comprehensive-genome-survey-provides-novel-insights-into-bile-salt-hydrolase-bsh-in-lactobacillaceae
#9
Lifeng Liang, Yunhai Yi, Yunyun Lv, Junwei Qian, Xuejing Lei, Gengyun Zhang
Bile salt hydrolase (BSH) is a well-known enzyme that has been commonly characterized in probiotic bacteria, as it has cholesterol-lowering effects. However, its molecular investigations are scarce. Here, we build a local database of BSH sequences from Lactobacillaceae (BSH⁻SDL), and phylogenetic analysis and homology searches were employed to elucidate their comparability and distinctiveness among species. Evolutionary study demonstrates that BSH sequences in BSH⁻SDL are divided into five groups, named BSH A, B, C, D and E here, which can be the genetic basis for BSH classification and nomenclature...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29747442/safety-evaluations-of-bifidobacterium-bifidum-bgn4-and-bifidobacterium-longum-bori
#10
Min Jeong Kim, Seockmo Ku, Sun Young Kim, Hyun Ha Lee, Hui Jin, Sini Kang, Rui Li, Tony V Johnston, Myeong Soo Park, Geun Eog Ji
Over the past decade, a variety of lactic acid bacteria have been commercially available to and steadily used by consumers. However, recent studies have shown that some lactic acid bacteria produce toxic substances and display properties of virulence. To establish safety guidelines for lactic acid bacteria, the Food and Agriculture Organization of the United Nations (FAO)/World Health Organization (WHO) has suggested that lactic acid bacteria be characterized and proven safe for consumers’ health via multiple experiments (e...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29743671/an-exclusive-metabolic-niche-enables-strain-engraftment-in-the-gut-microbiota
#11
Elizabeth Stanley Shepherd, William C DeLoache, Kali M Pruss, Weston R Whitaker, Justin L Sonnenburg
The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound perturbation, the bacterial strains that reside within an individual are mostly stable over time 1 . By contrast, the fate of exogenous commensal and probiotic strains applied to an established microbiota is variable, generally unpredictable and greatly influenced by the background microbiota2,3 . Therefore, analysis of the factors that govern strain engraftment and abundance is of critical importance to the emerging field of microbiome reprogramming...
May 9, 2018: Nature
https://www.readbyqxmd.com/read/29737394/effects-of-natural-deep-eutectic-solvents-on-lactic-acid-bacteria-viability-during-cryopreservation
#12
Ying Qiao, Hao-Liang Cai, Xi Yang, Yuan-Yuan Zang, Zhi-Gang Chen
In this study, a new method of cryopreservation of lactic acid bacteria (LAB) using natural deep eutectic solvents (NADESs) was developed. Survival rates of LAB during 24-h short-term and 180-day long-term cryostorage at - 20 °C were investigated. The results revealed that survival of Streptococcus thermophilus (S. thermophilus) in NADESs after 24 h of cryostorage was superior to survival of two other tested LAB. Moreover, survival was higher at a ratio of NADESs to S. thermophilus of 1:1 (v/v) than observed using a 4:1 (v/v) ratio...
May 8, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29734011/the-ability-of-human-intestinal-anaerobes-to-metabolize-different-oligosaccharides-novel-means-for-microbiota-modulation
#13
Riichi Ose, Katsuaki Hirano, Shintaro Maeno, Junichi Nakagawa, Seppo Salminen, Takumi Tochio, Akihito Endo
Prebiotic oligosaccharides are known to have significant impacts on gut microbiota and are thus widely used to program healthy microbiota composition and activity from infants to the elderly. Bifidobacteria and lactobacilli are among the major target microorganisms of oligosaccharides, but the metabolic properties of oligosaccharides in other predominant gut microbes have not been well characterized. In the present study, we demonstrated the metabolic properties of six oligosaccharides in 31 key gut anaerobes...
May 4, 2018: Anaerobe
https://www.readbyqxmd.com/read/29724529/the-effect-of-daily-fortified-yogurt-consumption-on-weight-loss-in-adults-with-metabolic-syndrome-a-10-week-randomized-controlled-trial
#14
M Mohammadi-Sartang, N Bellissimo, J O Totosy de Zepetnek, N R Brett, S M Mazloomi, M Fararouie, A Bedeltavana, M Famouri, Z Mazloom
BACKGROUND AND AIMS: Obesity is a complex and multifaceted condition. Thus, functional foods need investigation as novel adjunct treatments for obesity. The objective was to determine the effects of daily consumption of a fortified yogurt (FY) on weight loss in overweight and obese patients with metabolic syndrome on a caloric-restricted diet. METHODS AND RESULTS: This was a randomized, double-blind, 10-week study. Participants were randomly allocated to two groups receiving either two servings (2 × 250 g)/day of FY with whey protein, calcium, vitamin D, prebiotic fibre and probiotic cultures (n = 44) or a low-fat plain yogurt (PY) (n = 43)...
March 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29705796/clostridium-tyrobutyricum-protect-intestinal-barrier-function-from-lps-induced-apoptosis-via-p38-jnk-signaling-pathway-in-ipec-j2-cells
#15
Zhiping Xiao, Lujie Liu, Wenjing Tao, Xun Pei, Geng Wang, Minqi Wang
BACKGROUND/AIMS: The intestinal mucosa forms a physical and metabolic barrier against the diffusion of pathogens, toxins, and allergens from the lumen into the circulatory system. Early weaning, a critical phase in swine production, can compromise intestinal barrier function through mucosal damage and alteration of tight junction integrity Maintenance of intestinal barrier function plays a pivotal role in optimum gastrointestinal health. In this study, we investigated the effects of Clostridium tyrobutyricum (C...
April 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29705500/lactobacillus-paracasei-hii01-xylooligosaccharides-and-synbiotics-reduce-gut-disturbance-in-obese-rats
#16
Parameth Thiennimitr, Sakawdaurn Yasom, Wannipa Tunapong, Titikorn Chunchai, Keerati Wanchai, Anchalee Pongchaidecha, Anusorn Lungkaphin, Sasithorn Sirilun, Chaiyavat Chaiyasut, Nipon Chattipakorn, Siriporn C Chattipakorn
OBJECTIVES: The beneficial effects of pro-, pre-, and synbiotics on obesity with insulin resistance have been reported previously. However, the strain-specific effect of probiotics and the combination with various types of prebiotic fiber yield controversial outcomes and limit clinical applications. Our previous study demonstrated that the probiotic Lactobacillus paracasei (L. paracasei) HII01, prebiotic xylooligosaccharide (XOS), and synbiotics share similar efficacy in attenuating cardiac mitochondrial dysfunction in obese-insulin resistant rats...
March 20, 2018: Nutrition
https://www.readbyqxmd.com/read/29702430/metabolic-products-of-the-intestinal-microbiome-and-extremes-of-atherosclerosis
#17
Chrysi Bogiatzi, Gregory Gloor, Emma Allen-Vercoe, Gregor Reid, Ruth G Wong, Bradley L Urquhart, Vincent Dinculescu, Kelsey N Ruetz, Thomas J Velenosi, Michael Pignanelli, J David Spence
BACKGROUND AND AIMS: There is increasing awareness that the intestinal microbiome plays an important role in human health. We investigated its role in the burden of carotid atherosclerosis, measured by ultrasound as total plaque area. METHODS: Multiple regression with traditional risk factors was used to identify three phenotypes among 316/3056 patients attending vascular prevention clinics. Residual score (RES; i.e. the distance off the regression line, similar to standard deviation) was used to identify the 5% of patients with much less plaque than predicted by their risk factors (Protected, RES <-2), the 90% with about as much plaque as predicted (Explained, RES -2 to 2), and the 5% with much more plaque than predicted (Unexplained RES >2)...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29695124/genome-wide-comparison-reveals-a-probiotic-strain-lactococcus-lactis-wflu12-isolated-from-the-gastrointestinal-tract-of-olive-flounder-paralichthys-olivaceus-harboring-genes-supporting-probiotic-action
#18
Thanh Luan Nguyen, Do-Hyung Kim
Our previous study has shown that dietary supplementation with Lactococcus lactis WFLU12 can enhance the growth of olive flounder and its resistance against streptococcal infection. The objective of the present study was to use comparative genomics tools to investigate genomic characteristics of strain WFLU12 and the presence of genes supporting its probiotic action using sequenced genomes of L. lactis strains. Dispensable and singleton genes of strain WFLU12 were found to be more enriched in genes associated with metabolism (e...
April 24, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29692770/modulation-of-active-gut-microbiota-by-lactobacillus-rhamnosus-gg-in-a-diet-induced-obesity-murine-model
#19
Yosep Ji, Soyoung Park, Haryung Park, Eunchong Hwang, Hyeunkil Shin, Bruno Pot, Wilhelm H Holzapfel
Gut microbiota play a key role in the development of metabolic disorders. Defining and correlating structural shifts in gut microbial assemblages with conditions related to metabolic syndrome have, however, been proven difficult. Results from 16S genomic DNA and 16S ribosomal RNA analyses of fecal samples may differ widely, leading to controversial information on the whole microbial community and metabolically active microbiota. Using a C57BL/6J murine model, we compared data from 16S genomic DNA and ribosomal RNA of the fecal microbiota...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29685707/supplemental-flaxseed-modulates-ovarian-functions-of-weanling-gilts-via-the-action-of-selected-fatty-acids
#20
Radoslava Vlčková, Zuzana Andrejčáková, Drahomíra Sopková, Zdenka Hertelyová, Katarzyna Kozioł, Marek Koziorowski, Soňa Gancarčíková
The aim of this study was to examine the influence of dietary flaxseed on the endocrine and ovarian functions of weanling gilts challenged with E. coli and Coronavirus infections treated with dietary probiotic cheeses and to understand the possible mechanisms of its effects on ovarian function. Probiotics were used as a natural substitution for antibiotics and 10% dietary flaxseed is an effective prebiotic which supports the action of probiotics and has other beneficial effects on the organism. Probiotics with or without flaxseed were fed to weanling gilts starting 10 days before and lasting up until 14 days after weaning...
April 18, 2018: Animal Reproduction Science
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