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https://www.readbyqxmd.com/read/28103623/metabolic-inflexibility-with-obesity-and-the-effects-of-fenofibrate-on-skeletal-muscle-fatty-acid-oxidation
#1
Kristen E Boyle, Jacob E Friedman, Rachel C Janssen, Chantal Underkofler, Joseph A Houmard, Neda Rasouli
This study was designed to investigate mechanisms of lipid metabolic inflexibility in human obesity and the ability of fenofibrate (FENO) to increase skeletal muscle fatty acid oxidation (FAO) in primary human skeletal muscle cell cultures (HSkMC) exhibiting metabolic inflexibility. HSkMC from 10 lean and 10 obese, insulin resistant subjects were treated with excess fatty acid for 24 h (24hFA) to gauge lipid-related metabolic flexibility. Metabolically inflexible HSkMC from obese individuals were then treated with 24hFA in combination with FENO to determine effectiveness for increasing FAO...
January 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28103597/psychophysiological-effects-of-a-single-short-and-moderately-bright-room-light-exposure-on-mildly-depressed-geriatric-inpatients-a-pilot-study
#2
Markus Canazei, Wilfried Pohl, Kathrin Bauernhofer, Ilona Papousek, Helmut K Lackner, Harald R Bliem, Josef Marksteiner, Elisabeth M Weiss
BACKGROUND: Light interventions typically exert their mood-related effects during morning bright light exposures over several weeks. Evidence about immediate ambient room light effects on depressed individuals is still sparse. OBJECTIVE: The present study aimed at examining the acute effects of a single moderately bright room light exposure on mood, and behavioural and cardiac stress reactions of mildly depressed geriatric inpatients during a short cognitive stimulation and while resting...
January 20, 2017: Gerontology
https://www.readbyqxmd.com/read/28103592/influences-of-various-peptide-linkers-on-the-thermotoga-maritima-msb8-nitrilase-displayed-on-the-spore-surface-of-bacillus-subtilis
#3
Huayou Chen, Zhi Chen, Bangguo Wu, Jawad Ullah, Tianxi Zhang, Jinru Jia, Hongcheng Wang, Tianwei Tan
In the present study, fusion genes composed of Thermotoga maritima MSB8 nitrilase and Bacillus subtilis 168 outer coat protein CotG were constructed with various peptide linkers and displayed on B. subtilis DB 403 spores. The successful display of CotG-nit fusion proteins on the spore surface of B. subtilis was verified by Western blot analysis and activity measurement. It was demonstrated that the fusion with linker GGGGSEAAAKGGGGS presented the highest thermal and pH stability, which is 2.67- and 1.9-fold of the fusion without linker...
January 20, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28103567/predictive-control-of-networked-multiagent-systems-via-cloud-computing
#4
Guo-Ping Liu
This paper studies the design and analysis of networked multiagent predictive control systems via cloud computing. A cloud predictive control scheme for networked multiagent systems (NMASs) is proposed to achieve consensus and stability simultaneously and to compensate for network delays actively. The design of the cloud predictive controller for NMASs is detailed. The analysis of the cloud predictive control scheme gives the necessary and sufficient conditions of stability and consensus of closed-loop networked multiagent control systems...
January 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103564/mograms-a-network-based-methodology-for-visualizing-the-set-of-nondominated-solutions-in-multiobjective-optimization
#5
Krzysztof Trawinski, Manuel Chica, David P Pancho, Sergio Damas, Oscar Cordon
An appropriate visualization of multiobjective nondominated solutions is a valuable asset for decision making. Although there are methods for visualizing the solutions in the design space, they do not provide any information about their relationship. In this paper, we propose a novel methodology that allows the visualization of the nondominated solutions in the design space and their relationships by means of a network. The nodes represent the solutions in the objective space while the edges show the relationships among the solutions in the design space...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103561/statistical-shape-modeling-of-the-left-ventricle-myocardial-infarct-classification-challenge
#6
Avan Suinesiaputra, Pierre Ablin, Xenia Alba, Martino Alessandrini, Jack Allen, W Bai, Serkan Cimen, Peter Claes, Brett R Cowan, Jan D'hooge, Nicolas Duchateau, Jan Ehrhardt, Alejandro F Frangi, Ali Gooya, Vicente Grau, Karim Lekadir, Allen Lu, Anirban Mukhopadhyay, Ilkay Oksuz, Xavier Pennec, Marco Pereanez, Catarina Pinto, Paolo Piras, Marc-Michel Rohe, Daniel Rueckert, Maxime Sermesant, Kaleem Siddiqi, Mahdi Tabassian, Luciano Teresi, Sotirios A Tsaftaris, Matthias Wilms, Alistair A Young, Xingyu Zhang, Pau Medrano-Gracia
Statistical shape modeling is a powerful tool for visualizing and quantifying geometric and functional patterns of the heart. After myocardial infarction (MI), the left ventricle typically remodels in response to physiological challenges. Several methods have been proposed in the literature to describe statistical shape changes. Which method best characterizes left ventricular remodeling after MI is an open research question. A better descriptor of remodeling is expected to provide a more accurate evaluation of disease status in MI patients...
January 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103542/interactive-exploration-of-3d-scanned-baggage
#7
Michael Traore, Christophe Hurter
An interactive visualization system can support volumetric data exploration in airport security screenings by addressing the challenges unique to the baggage inspection. The proposed system includes a set of interaction techniques that combine the direct manipulation of voxels and their interactive visualization. The system's final tools and GUI design incorporate feedback from airport personnel and were validated by real-world users in terms of effectiveness and ease of use.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103539/algorithm-animation-with-galant
#8
Matthias F Stallmann
Although surveys suggest positive student attitudes toward the use of algorithm animations, it is not clear that they improve learning outcomes. The Graph Algorithm Animation Tool, or Galant, challenges and motivates students to engage more deeply with algorithm concepts, without distracting them with programming language details or GUIs. Even though Galant is specifically designed for graph algorithms, it has also been used to animate other algorithms, most notably sorting algorithms.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103538/taking-flight
#9
Gary Singh
Dolores Kaufman often begins her pieces by transmuting scanned photos and objects into new digital images. She seeks to explore the mystery and symbolism embedded in the seemingly mundane ephemera with which we share our lives. Kaufman's Eye Sea will be included in the MoonArk, a six-inch-tall capsule designed by a team at Carnegie Mellon University that will be travelling to the moon in competition for the Google Lunar X Prize.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103537/hybrids-of-thienopyrimidinones-and-thiouracils-as-anti-tubercular-agents-sar-and-docking-studies
#10
Mahesh M Pisal, Laxman U Nawale, Manoj D Patil, Sujit G Bhansali, Jayant M Gajbhiye, Dhiman Sarkar, Subhash P Chavan, Hanumant B Borate
A number of hybrid molecules containing thienopyrimidinones and thiouracil moieties were designed, synthesized and tested against Mycobacterium tuberculosis H37Ra wherein it was observed that the compounds 11-14 exhibited antitubercular activity in vitro (MIC 7.6-19.1 μg/mL, 12-35 μM) against dormant stage while the compound 15 exhibited antitubercular activity in vitro against dormant (MIC 23.4 μg/mL, 41 μM) as well as active (MIC 25.4 μg/mL, 45 μM) stage. Structural modifications of the compound 15 were carried out to study the structure-activity relationship and it was observed that the compound 18 exhibited antitubercular activity comparable to the compound 15...
January 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28103529/improving-osteogenesis-of-three-dimensional-porous-scaffold-based-on-mineralized-recombinant-human-like-collagen-via-mussel-inspired-polydopamine-and-effective-immobilization-of-bmp-2-derived-peptide
#11
Jing Zhou, Xiaodong Guo, Qixin Zheng, Yongchao Wu, Fuzai Cui, Bin Wu
An ideal bone substitute should be biocompatible, biodegradable, osteoinductive and osteoconductive. In our previous work, we fabricated a three-dimensional porous scaffold based on mineralized recombinant human-like collagen, nano-hydroxyapatite/recombinant human-like collagen/poly(lactic acid) (nHA/RHLC/PLA). Like other HA/collagen scaffolds, the nHA/RHLC/PLA scaffold lacked osteoinductive bioactivity. The purpose of the present study was to develop a polydopamine (pDA)-assisted BMP-2-derived peptide (designated as P24) surface modification strategy for improving the osteogenesis of the nHA/RHLC/PLA scaffold...
January 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103524/validation-of-a-bicycle-simulator-for-road-safety-research
#12
Steve O'Hern, Jennie Oxley, Mark Stevenson
The study's aim was to assess the behavioural validity of participants using of a newly developed bicycle simulator with respect to a range of cycling performance measures collected both using the cycling simulator and on-road. The validation study consisted of a within-subjects study design comparing participants riding on-road with riding in the simulator. The study recruited 26 participants ranging in age from 18 to 35 years (M=25.0, SD=4.8). Absolute validity was established for measures of spatial positioning including average lane position, deviation in lane position and average passing distance from kerbside parked cars...
January 16, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28103494/factors-associated-with-meeting-physical-activity-guidelines-by-adults-with-intellectual-and-developmental-disabilities
#13
Roger J Stancliffe, Lynda L Anderson
BACKGROUND: Many individuals with intellectual and developmental disabilities (IDD) have sedentary lifestyles. AIMS: (a) compare adults with IDD with the general adult population on adherence to U.S. physical activity (PA) guidelines, and (b) determine what factors predict adherence to PA guidelines by adults with IDD. METHODS: We compared adults with IDD from the 2011-2012 National Core Indicators Adult Consumer Survey (NCI-ACS) with the general U...
January 16, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28103456/health-inequalities-in-diabetes-mellitus-and-hypertension-a-parish-level-study-in-the-northern-region-of-portugal
#14
Teresa Leao, Julian Perelman, Manuela Felício, Vasco Machado, Graça Lima
INTRODUCTION: Diabetes and hypertension are highly prevalent conditions in Portugal. Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies. This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the population resident in the Northern region of Portugal, for the year 2013. MATERIAL AND METHODS: An ecological correlation study analyzed the 2,028 parishes of the region...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103438/acylguanidine-beta-secretase-1-inhibitors-a-combined-experimental-and-free-energy-perturbation-study
#15
Henrik Keränen, Laura Pérez-Benito, Myriam Ciordia, Francisca Delgado, Thomas B Steinbrecher, Daniel Oehlrich, Herman W T Van Vlijmen, Andrés A Trabanco, Gary Tresadern
A series of acylguanidine beta secretase 1 (BACE1) inhibitors with modified scaffold and P3 pocket substituent was synthesized and studied with Free Energy Perturbation (FEP) calculations. The resulting molecules showed potencies in enzymatic BACE1 inhibition assays up to 1 nM. The correlation between the predicted activity from the FEP calculations and the experimental activity was good for the P3 pocket substituents. The average mean unsigned error (MUE) between prediction and experiment was 0.68 ± 0.17 kcal/mol for the default 5 ns lambda window simulation time improving to 0...
January 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28103415/predictors-of-ptsd-symptom-change-among-outpatients-in-the-u-s-department-of-veterans-affairs-health-care-system
#16
Rebecca K Sripada, Paul N Pfeiffer, Jessica Rampton, Dara Ganoczy, Sheila A M Rauch, Melissa A Polusny, Kipling M Bohnert
Although the U.S. Department of Veterans Affairs (VA) has prioritized care for posttraumatic stress disorder (PTSD), many patients with PTSD remain symptomatic. Patterns of PTSD symptom change are not well understood. Thus, the current study was designed to categorize and investigate potential predictors of symptom trajectories in patients with PTSD. The sample comprised 2,237 VA patients who were diagnosed with PTSD in 2013 and completed at least 4 PTSD Checklist (PCL) assessments over 12 weeks. Latent trajectory analysis was used to identify latent classes of patients based on PCL scores...
January 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28103394/measuring-patient-engagement-which-health-care-engagement-behaviors-are-important-to-patients
#17
Huey-Ming Tzeng, James Marcus Pierson
AIM(S): This study identified patient health care engagement behaviors that are important to community-dwelling adult patients living in the southern region of the USA. BACKGROUND: Patient engagement has been identified as a key driver for containing health care costs, but the public and health care professionals lack a scientific understanding of patient engagement. A valid tool is needed for prompting patients to discuss health activities with their health care providers and to obtain support...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28103321/derivative-of-extremophilic-50s-ribosomal-protein-l35ae-as-an-alternative-protein-scaffold
#18
Anna V Lomonosova, Andrei B Ulitin, Alexei S Kazakov, Tajib A Mirzabekov, Eugene A Permyakov, Sergei E Permyakov
Small antibody mimetics, or alternative binding proteins (ABPs), extend and complement antibody functionality with numerous applications in research, diagnostics and therapeutics. Given the superiority of ABPs, the last two decades have witnessed development of dozens of alternative protein scaffolds (APSs) for the design of ABPs. Proteins from extremophiles with their high structural stability are especially favorable for APS design. Here, a 10X mutant of the 50S ribosomal protein L35Ae from hyperthermophilic archaea Pyrococcus horikoshii has been probed as an APS...
2017: PloS One
https://www.readbyqxmd.com/read/28103318/static-and-evolving-norovirus-genotypes-implications-for-epidemiology-and-immunity
#19
Gabriel I Parra, R Burke Squires, Consolee K Karangwa, Jordan A Johnson, Cara Lepore, Stanislav V Sosnovtsev, Kim Y Green
Noroviruses are major pathogens associated with acute gastroenteritis worldwide. Their RNA genomes are diverse, with two major genogroups (GI and GII) comprised of at least 28 genotypes associated with human disease. To elucidate mechanisms underlying norovirus diversity and evolution, we used a large-scale genomics approach to analyze human norovirus sequences. Comparison of over 2000 nearly full-length ORF2 sequences representing most of the known GI and GII genotypes infecting humans showed a limited number (≤5) of distinct intra-genotypic variants within each genotype, with the exception of GII...
January 19, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103312/increased-cardiovascular-events-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients-1-year-prospective-single-centre-study
#20
Piero Ruscitti, Paola Cipriani, Francesco Masedu, Silvio Romano, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Di Benedetto, Saverio Alvaro, Maria Penco, Marco Valenti, Roberto Giacomelli
OBJECTIVES: Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the occurrence of new CVEs and the onset of subclinical atherosclerosis. METHODS: We designed a single centre, bias-adjusted, prospective, observational study to investigate, in a homogeneous subset of RA patients, the occurrence of new onset of CVEs and subclinical atherosclerosis...
2017: PloS One
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