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https://www.readbyqxmd.com/read/28532138/a-case-based-shared-teaching-approach-in-undergraduate-medical-curriculum-a-way-for-integration-in-basic-and-clinical-sciences
#1
Soheil Peiman, Azim Mirzazadeh, Maryam Alizadeh, Sara Mortaz Hejri, Mohammad-Taghi Najafi, Abbas Tafakhori, Farnoosh Larti, Besharat Rahimi, Babak Geraiely, Parichehr Pasbakhsh, Gholamreza Hassanzadeh, Fatemeh Nabavizadeh Rafsanjani, Mohammad Ansari, Seyed Farshad Allameh
To present a multiple-instructor, active-learning strategy in the undergraduate medical curriculum. This educational research is a descriptive one. Shared teaching sessions, were designed for undergraduate medical students in six organ-system based courses. Sessions that involved in-class discussions of integrated clinical cases were designed implemented and moderated by at least 3 faculties (clinicians and basic scientists). The participants in this study include the basic sciences medical students of The Tehran University of Medical Sciences...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532128/band-offset-measurements-in-atomic-layer-deposited-al2o3-zn0-8al0-2o-heterojunction-studied-by-x-ray-photoelectron-spectroscopy
#2
Baojun Yan, Shulin Liu, Yuekun Heng, Yuzhen Yang, Yang Yu, Kaile Wen
Pure aluminum oxide (Al2O3) and zinc aluminum oxide (Zn x Al1-x O) thin films were deposited by atomic layer deposition (ALD). The microstructure and optical band gaps (E g ) of the Zn x Al1-x O (0.2 ≤ x ≤ 1) films were studied by X-ray diffractometer and Tauc method. The band offsets and alignment of atomic-layer-deposited Al2O3/Zn0.8Al0.2O heterojunction were investigated in detail using charge-corrected X-ray photoelectron spectroscopy. In this work, different methodologies were adopted to recover the actual position of the core levels in insulator materials which were easily affected by differential charging phenomena...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532091/design-and-fabrication-of-carbon-fibers-with-needle-like-nano-ha-coating-to-reinforce-granular-nano-ha-composites
#3
Xudong Wang, Xueni Zhao, Li Zhang, Wanying Wang, Jing Zhang, Fuzhen He, Jianjun Yang
Carbon fibers (CFs) with needle-like nano-hydroxyapatite (nHA) coating were first used as reinforcing materials named nHA-CFs to improve the mechanical properties of pure HA. A powder mixture containing nHA-CFs and granular nano-HA (gHA) was directly sintered by hot pressing at appropriate sintering pressure and temperature. A three-phase nHA-CFs/gHA composite was designed, fabricated, and used as an artificial bone. Results show that the bending strengths of the nHA-CFs/gHA composite are approximately 41.1% and 59...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532088/mussel-inspired-surface-modification-of-titania-nanotubes-as-a-novel-drug-delivery-system
#4
Negin Khoshnood, Ali Zamanian, Abouzar Massoudi
Titania nanotubes (TNTs) have attracted considerable attention for the development of new devices for local drug delivery applications. In this study TNTs were synthesized by hydrothermal method from titania nanoparticles and then the surface of TNTs were functionalized by in situ polymerization of bioinspired polydopamine (PDA). The proposed strategies emphasized on remarkable properties of these materials and their unique combination to design local drug delivery system with advanced performance. The samples were characterized using Transmission Electron Microscope (TEM), Field Emission Scanning Electron Microscope (FESEM), X-ray diffraction pattern (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and surface area analysis (BET)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532085/mesoporous-nano-bioglass-designed-for-the-release-of-imatinib-and-in-vitro-inhibitory-effects-on-cancer-cells
#5
Muhammad Shoaib, Aamer Saeed, Muhammad Saif Ur Rahman, Muhammad Moazzam Naseer
For treating bone cancer, controlled drug delivery is an important strategy. Bioactive scaffolds are widely used biomaterials due to their usefulness in localized drug delivery. The aim of this study was to develop mesoporous bioglass (MBG) with improved bioactivity and controllable drug delivery rate. By using pluronic 123 (P123) as a template, a facile sol-gel route was employed for the synthesis of MBG nanoparticles (NPs). The composition of the prepared sample was estimated by using energy dispersive X-ray spectroscopy (EDX)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532072/new-bioactive-bone-like-microspheres-with-intrinsic-magnetic-properties-obtained-by-bio-inspired-mineralisation-process
#6
Tatiana Marisa Fernandes Patrício, Silvia Panseri, Monica Sandri, Anna Tampieri, Simone Sprio
A bio-inspired mineralisation process was investigated and applied to develop novel hybrid magnetic materials by heterogeneous nucleation of Fe(2+)/Fe(3+)-doped hydroxyapatite nanocrystals onto a biopolymeric matrix made of a Type I collagen-based recombinant peptide (RCP). The effect of the synthesis temperature on the phase composition, crystallinity and magnetic properties of the nucleated inorganic phase was studied. The as-obtained magnetic materials were then engineered, by using a water-in-oil emulsification process, into hybrid magnetic microspheres, which were stabilized by de-hydrothermal treatment yielding cross-linking of the macromolecular matrix...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532067/development-of-biocompatible-and-safe-polyethersulfone-hemodialysis-membrane-incorporated-with-functionalized-multi-walled-carbon-nanotubes
#7
Muhammad Nidzhom Zainol Abidin, Pei Sean Goh, Ahmad Fauzi Ismail, Mohd Hafiz Dzarfan Othman, Hasrinah Hasbullah, Noresah Said, Siti Hamimah Sheikh Abdul Kadir, Fatmawati Kamal, Mohd Sohaimi Abdullah, Be Cheer Ng
A novel approach in the design of a safe, high performance hemodialysis membrane is of great demand. Despite many advantages, the employment of prodigious nanomaterials in hemodialysis membrane is often restricted by their potential threat to health. Hence, this work focusses on designing a biocompatible polyethersulfone (PES) hemodialysis membrane embedded with poly (citric acid)-grafted-multi walled carbon nanotubes (PCA-g-MWCNTs). Two important elements which could assure the safety of the nanocomposite membrane, i...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532066/design-and-characterization-of-a-novel-nickel-free-cobalt-base-alloy-for-intravascular-stents
#8
Qiang Wang, Yibin Ren, M Babar Shahzad, Wei Zhang, Xumeng Pan, Song Zhang, Dan Zhang
Co-Cr-W-Ni alloy (L605) with high tensile strength is used in coronary stents. The thickness of individual strut of the stent is reduced which can decrease the stent restenosis rate. However, about 10% Ni element content in L605 is found to cause allergic reactions and pulmonary embolism, similar to the traditional 316L stainless steel. In this study, a novel nickel-free cobalt-base alloy Co-20Cr-12Fe-18Mn-2Mo-4W-N (wt%) was designed and fabricated in order to efficiently avoid the potential hazards of Ni element...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532060/design-and-characterization-of-biodegradable-macroporous-hybrid-inorganic-organic-polymer-for-orthopedic-applications
#9
Sunita PremVictor, Jibin Kunnumpurathu, M G Gayathri Devi, K Remya, Vineeth M Vijayan, Jayabalan Muthu
We have engineered hybrid polymer products based on a hybrid inorganic-organic comacromer consisting of hydroxyapatite (HA), carboxyl terminated polypropylene fumarate (CTPPF), PEG300 and ascorbic acid (AA) as a bone graft material. The integration and the spatial distribution of HA in the polymer backbone were facilitated by silanisation and 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) coupling technique. These comacromers and crosslinked polymer products were characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM) and Raman mapping techniques...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532053/functionalized-fe3o4-graphene-oxide-nanocomposites-with-hairpin-aptamers-for-the-separation-and-preconcentration-of-trace-pb-2-from-biological-samples-prior-to-determination-by-icp-ms
#10
Mojtaba Shamsipur, Leila Farzin, Mahmoud Amouzadeh Tabrizi, Shahab Sheibani
Lead (Pb) as a topically poisonous metal represents a serious threat to the ecological environment and especially to human beings. Therefore, it is urgent to develop a rapid and reliable monitoring technique for this heavy metal in the environmental samples. In the present study, we have designed a selective and sensitive method for the determination of ultratrace contents of Pb(2+) in biological samples, based on the guanine (G)-quadruplex formed by the aptamer with hairpin structure and Pb(2+). For this purpose, Pb(2+) specific aptamer serving as affinity probe to capture and separate trace amounts of the analyte, was covalently linked to Fe3O4/graphene oxide (GO) surface by using a suitable cross-linking agent...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532041/comparative-analysis-of-stress-in-a-new-proposal-of-dental-implants
#11
Mariana Lima da Costa Valente, Denise Tornavoi de Castro, Ana Paula Macedo, Antonio Carlos Shimano, Andréa Cândido Dos Reis
The purpose of this study was to compare, through photoelastic analysis, the stress distribution around conventional and modified external hexagon (EH) and morse taper (MT) dental implant connections. Four photoelastic models were prepared (n=1): Model 1 - conventional EH cylindrical implant (Ø 4.0mm×11mm - Neodent®), Model 2 - modified EH cylindrical implant, Model 3 - conventional MT Conical implant (Ø 4.3mm×10mm - Neodent®) and Model 4 - modified MT conical implant. 100 and 150N axial and oblique loads (30° tilt) were applied in the devices coupled to the implants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532040/design-synthesis-and-characterization-of-poly-methacrylic-acid-niclosamide-and-its-effect-on-arterial-function
#12
Rui Ma, Zhen-Gang Ma, Chang-Lin Zhen, Xin Shen, Shan-Liang Li, Li Li, Yu-Feng Zheng, De-Li Dong, Zhi-Jie Sun
We have found that niclosamide induced relaxation of constricted artery. However, niclosamide is insoluble, the low bioavailability and the resultant low plasma concentration limit its potential exertion in vivo. The aim of the present study is to synthesize a soluble poly (methacrylic acid-niclosamide) polymer (PMAN) and study the effects of PMAN on arterial function in vitro and the blood pressure and heart rate of rats in vivo. We synthesized the poly (methacrylic acid-niclosamide) polymer (PMAN), the chemical structure of which was identified by FTIR and (1)H NMR spectra...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532037/multifactor-analysis-on-the-effect-of-collagen-concentration-cross-linking-and-fiber-pore-orientation-on-chemical-microstructural-mechanical-and-biological-properties-of-collagen-type-i-scaffolds
#13
E Suesca, A M A Dias, M E M Braga, H C de Sousa, M R Fontanilla
This work evaluates the effect of processing variables on some physicochemical and mechanical properties of multi- and unidirectional laminar collagen type I scaffolds. The processing variables considered in this study included microstructure orientation (uni- and multidirectional fiber/pore controlled by freeze-drying methodology), cross-linking (chemical - using genipin and glutaraldehyde, and physical - using a dehydrothermal method), and collagen concentration (2, 5 and 8mg/ml). The biocompatibility of the scaffolds obtained in each of the evaluated manufacturing processes was also assessed...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532036/facile-fabrication-of-pan-pdms-core-shell-nanofibers-from-synchronous-photopolymerization
#14
Qijian Niu, Xiaolei Zhu, Yunhui Tang, Jun Nie, Guiping Ma
Different from the traditional method for fabricating core-shell structure nanofiber, the PAN/PDMS nanofibers with core-shell structure (PAN as the core layer and PDMS as the shell layer) have been illustrated, which combines with the synchronous photopolymerization during emulsion electrospinning process. The morphology and structure of as-fabricated PAN/PDMS nanofibers are characterized by SEM and TEM. The composition of PAN/PDMS nanofibers is characterized by FTIR, XPS, TG, and DTG, successfully. The photopolymerization process is characterized by UV-vis spectroscopy indirectly...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532035/honey-pva-hybrid-wound-dressings-with-controlled-release-of-antibiotics-structural-physico-mechanical-and-in-vitro-biomedical-studies
#15
Javad Tavakoli, Youhong Tang
Hydrogel/honey hybrids manifest an attractive design with an exclusive therapeutic property that promotes wound healing process. The greater the concentration of honey within the formulation, the better the biomedical properties that will be achieved. However, an increase in the percentage of honey can negatively affect the physico-chemical and mechanical properties of hybrid hydrogels. The need exists, therefore, to prepare wound dressings that contain high honey density with optimal biomedical, mechanical and physicochemical properties...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532031/screening-of-process-variables-to-enhance-the-solubility-of-famotidine-with-2-hydroxypropyl-%C3%AE-cyclodextrin-pvp-k-30-by-using-plackett-burman-design-approach
#16
Umakant Verma, Jitendra B Naik, Jayesh S Patil, Sunil K Yadava
In the present work, inclusion complex of famotidine (FMT) was prepared with (2-HydroxyPropyl)-β-Cyclodextrin (HP-β-CyD) and polyvinylpyrrolidone K-30 (PVP K-30) by spray drying technique to enhance the solubility of famotidine. FMT is a potent histamine H2-receptor antagonist having low solubility as well as oral bioavailability. In order to enhance the solubility of FMT, a quality by design (QbD) approach has been used by employing Plackett-Burman design (PBD). With the application of PBD, seven independent process variables were investigated and optimized for maximum solubility...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532024/the-effect-of-pore-size-and-porosity-on-mechanical-properties-and-biological-response-of-porous-titanium-scaffolds
#17
C Torres-Sanchez, F R A Al Mushref, M Norrito, K Yendall, Y Liu, P P Conway
The effect of pore size and porosity on elastic modulus, strength, cell attachment and cell proliferation was studied for Ti porous scaffolds manufactured via powder metallurgy and sintering. Porous scaffolds were prepared in two ranges of porosities so that their mechanical properties could mimic those of cortical and trabecular bone respectively. Space-holder engineered pore size distributions were carefully determined to study the impact that small changes in pore size may have on mechanical and biological behaviour...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532012/an-overview-of-carboxymethyl-derivatives-of-chitosan-their-use-as-biomaterials-and-drug-delivery-systems
#18
REVIEW
Bruno Fonseca-Santos, Marlus Chorilli
Chitin is one of the most abundant natural polymers in the world and is used for the production of chitosan by deacetylation. Chitosan is nontoxic and biodegradable and, therefore, can be used as a biomaterial and for the construction of drug delivery systems. Nevertheless, the poor solubility of chitosan in neutral or alkalinized media has restricted its applications in the pharmaceutical and biomedical fields. Chitosan can be easily carboxymethylated to improve its solubility in aqueous media while its biodegradability and biocompatibility are preserved...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532011/molecularly-imprinted-polymer-for-human-viral-pathogen-detection
#19
REVIEW
Aijaz Ahmad Malik, Chanin Nantasenamat, Theeraphon Piacham
Molecular imprinting has become an attractive synthetic approach for the fabrication of novel functional polymers with pre-designed molecular target selectivity. Such molecularly imprinted polymers (MIPs) have been applied in wide range of areas such as chemical and biological sensors, solid phase extraction and drug assays owing to their inherent robustness, reusability and reproducibility. Furthermore, MIPs can also be used as tools for studies concerning antibody/receptor binding site mimicry as well as being used as antibody substitutes for biomedical applications...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532010/design-of-experiments-for-microencapsulation-applications-a-review
#20
REVIEW
Filipa Paulo, Lúcia Santos
Microencapsulation techniques have been intensively explored by many research sectors such as pharmaceutical and food industries. Microencapsulation allows to protect the active ingredient from the external environment, mask undesired flavours, a possible controlled release of compounds among others. The purpose of this review is to provide a background of design of experiments in microencapsulation research context. Optimization processes are required for an accurate research in these fields and therefore, the right implementation of micro-sized techniques at industrial scale...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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