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https://www.readbyqxmd.com/read/28526535/tnf-%C3%AE-is-superior-to-conventional-inflammatory-mediators-in-forecasting-ivig-nonresponse-and-coronary-arteritis-in-chinese-children-with-kawasaki-disease
#1
Peng Hu, Guang Mei Jiang, Yue Wu, Bao Yu Huang, Si Yan Liu, Dong Dong Zhang, Yao Xu, Yang Fang Wu, Xun Xia, Wei Wei, Bo Hu
BACKGROUND: Tumor necrosis factor (TNF) -α is of inflammatory cytokines produced chiefly by activated monocyte/macrophages, and has been implicated in the pathogenesis of Kawasaki disease (KD). We elucidated the relationship of plasma TNF-α with conventional inflammatory mediators, clinical classification, intravenous immunoglobulin (IVIG) response and coronary arteritis in the course of KD. METHODS: Seventy Chinese children with KD were enrolled and divided into 6 subgroups, including complete KD, incomplete KD, IVIG-responsive KD, IVIG-nonresponsive KD, coronary artery (CA) -noninvolvement KD and CA-involvement KD...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28523283/variable-temporal-sampling-and-tube-current-modulation-for-myocardial-blood-flow-estimation-from-dose-reduced-dynamic-computed-tomography
#2
Dimple Modgil, Michael D Bindschadler, Adam M Alessio, Patrick J La Rivière
Quantification of myocardial blood flow (MBF) can aid in the diagnosis and treatment of coronary artery disease. However, there are no widely accepted clinical methods for estimating MBF. Dynamic cardiac perfusion computed tomography (CT) holds the promise of providing a quick and easy method to measure MBF quantitatively. However, the need for repeated scans can potentially result in a high patient radiation dose, limiting the clinical acceptance of this approach. In our previous work, we explored techniques to reduce the patient dose by either uniformly reducing the tube current or by uniformly reducing the number of temporal frames in the dynamic CT sequence...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28523165/plasma-levels-of-matrix-metalloproteinase-9-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#3
Haiqing Li, Zhize Yuan, Sen Li, Quan Qi, Jun Liu, Mi Zhou, Junfeng Cai, Anqing Chen, Zhe Wang, Xiaofeng Ye, Qiang Zhao
BACKGROUND: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases. However, little is known about the significance of increased plasma MMP9 in patients with perioperative myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of myocardial injury during off-pump coronary artery bypass grafting (OPCAB). METHODS: A total of 34 consecutive patients with coronary artery diseases (CAD) were recruited in this prospective, observational study...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28522699/greater-frequency-of-fruit-and-vegetable-consumption-is-associated-with-lower-prevalence-of-peripheral-artery-disease
#4
Sean P Heffron, Caron B Rockman, Mark A Adelman, Eugenia Gianos, Yu Guo, Jin Feng Xu, Jeffrey S Berger
OBJECTIVE: Although fruit and vegetable (F&V) consumption is associated with lower risk of coronary heart disease and stroke, its association with peripheral artery disease (PAD) is less certain. We, thus, sought to characterize F&V intake and investigate the association between F&V consumption and presence of PAD in a large community sample. APPROACH AND RESULTS: Self-referred participants at >20 000 US sites who completed medical and lifestyle questionnaires were evaluated by screening ankle brachial indices for PAD (ankle brachial index ≤0...
May 18, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28522356/association-between-matrix-metaloproteinases-2-1306c-t-polymorphism-and-the-risk-of-coronary-artery-disease-in-iranian-population
#5
Mahshid Sattari, Maryam Hassanzad, Seyed Hamid Jamaldini, Alireza Najafi, Mahdieh Imani, Mohammadreza Mohammadhassani, Mandana Hasanzad
BACKGROUND: Coronary Artery Disease (CAD) represents the most important cause of sudden cardiac death. Interaction between genetic and environmental factors, individual susceptibility of the development of CAD is one of the MMP2 genes. Genetic variants' dysfunction of the MMP2 gene associated with the risk of CAD. The aim of the present study is to assess possible association between risk of Coronary Artery Disease and MMP2-1306C/T polymorphism. METHODS: This case-control study contains a total number of 344 subjects, including 215 patients with CAD and 129 of controls...
May 6, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28521548/mitochondrial-dna-heteroplasmy-in-cardiac-tissue-from-individuals-with-and-without-coronary-artery-disease
#6
Erik Hefti, Javier Guillermo Blanco
The cellular environment associated with coronary artery disease (CAD) can lead to mitochondrial DNA (mtDNA) damage. Mitochondrial variants in some copies of mtDNA (heteroplasmy) and mtDNA content are potential genetic biomarkers for CAD-associated disease states. Massively parallel sequencing and qRT-PCR techniques were used to measure heteroplasmic variants and mtDNA content in heart samples from donors with (n = 8) and without (n = 7) documented CAD. Both groups showed increased numbers of heteroplasmic mtDNA variants in the control region (CR) (p < ...
May 19, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28520861/influence-of-practice-patterns-on-outcome-among-countries-enrolled-in-the-syntax-trial-5-year-results-between-percutaneous-coronary-intervention-and-coronary-artery-bypass-grafting%C3%A2
#7
Milan Milojevic, Stuart J Head, Michael J Mack, Friedrich W Mohr, Marie-Claude Morice, Keith D Dawkins, David R Holmes, Patrick W Serruys, Arie Pieter Kappetein
OBJECTIVES: To examine differences among participating countries in baseline characteristics, clinical practice, medication strategies and outcomes of patients randomized to coronary artery bypass grafting and percutaneous coronary intervention in the SYNTAX trial. METHODS: In SYNTAX, centres in 18 different countries enrolled 1800 patients, of which 8 countries enrolled ≥80 patients, what was projected to be a large enough sample size to be included in the analysis...
May 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28518204/integrated-metabolomics-and-metallomics-analyses-in-acute-coronary-syndrome-patients
#8
Xuejiao Yin, Leonardo Pinto de Carvalho, Mark Y Chan, Sam Fong Yau Li
Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality. Accurate risk prediction in ACS patients is critically important for helping clinicians make therapeutic decisions, such as recommending a more aggressive intervention and intensive follow-up. However, risk stratification in ACS patients remains challenging, and the identification of novel predictors is necessary for improving the prognostic prediction in ACS patients. We employed metallomics and untargeted metabolomics approaches to discover new biomarkers from the plasma samples of 20 ACS patients and 20 non-ACS patients...
May 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28515798/epigenome-wide-association-of-myocardial-infarction-with-dna-methylation-sites-at-loci-related-to-cardiovascular-disease
#9
Masahiro Nakatochi, Sahoko Ichihara, Ken Yamamoto, Keiko Naruse, Shigeki Yokota, Hiroyuki Asano, Tatsuaki Matsubara, Mitsuhiro Yokota
BACKGROUND: Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial infarction (MI), we performed an epigenome-wide association study for this condition in elderly Japanese subjects. A total of 192 case subjects with MI and 192 control subjects were recruited from hospital attendees and the general population, respectively. Genome-wide DNA methylation (DNAm) profiles for DNA isolated from whole blood were obtained by analysis with an Infinium HumanMethylation450 BeadChip...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28515044/exploring-the-causal-pathway-from-telomere-length-to-coronary-heart-disease-a-network-mendelian-randomization-study
#10
Yiqiang Zhan, Ida K Karlsson, Robert Karlsson, Annika Tillander, Chandra A Reynolds, Nancy L Pedersen, Sara Hägg
Rationale: Observational studies have found shorter leukocyte telomere length to be a risk factor for coronary heart disease (CHD), and more recently the association was suggested to be causal. However, the relationship between telomere length and common metabolic risk factors for CHD is not well understood. Whether these risk factors could explain pathways from telomere length to CHD warrants further attention. Objective: To examine if metabolic risk factors for CHD mediate the causal pathway from short telomere length to increased risk of CHD using a network Mendelian randomization (MR) design...
May 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28514806/human-epicardial-fat-expresses-glucagon-like-peptide-1-and-2-receptors-genes
#11
Gianluca Iacobellis, Vladimir Camarena, David W Sant, Gaofeng Wang
Epicardial adipose tissue (EAT) is an easily measurable visceral fat of the heart with unique anatomy, functionality, and transcriptome. EAT can serve as a therapeutic target for pharmaceutical agents targeting the fat. Glucagon-like peptide-1 (GLP-1) and GLP-2 analogues are newer drugs showing beneficial cardiovascular and metabolic effects. Whether EAT expresses GLP- 1 and 2 receptors (GLP-1R and GLP-2R) is unknown. RNA-seq analysis and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to evaluate the presence of GLP-1R and GLP-2R in EAT and subcutaneous fat (SAT) obtained from 8 subjects with coronary artery disease and type 2 diabetes mellitus undergoing elective cardiac surgery...
May 17, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28514498/decreased-bed-rest-post-percutaneous-coronary-intervention-with-a-7-fr-arterial-sheath-and-its-effects-on-vascular-complications
#12
Laura J Wentworth, Elizabeth L Bechtum, Jessica G Hoffman, Robert R Kramer, David C Bartel, Joshua P Slusser, R Thomas Tilbury
AIMS AND OBJECTIVE: To compare the incidence of femoral access puncture site complications in the control group, who underwent 6 hours of bed rest, with patients in the case group, who underwent 4 hours of bed rest. BACKGROUND: The ideal bed rest length after percutaneous coronary intervention with a 7-French arterial sheath has been investigated by nursing practice. However, in this larger-sheath-size group, best practices have not been determined, and bed rest time continues to vary markedly among institutions...
May 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28514396/-long-term-results-of-different-approaches-to-revascularization-in-non-st-segment-elevation-acute-coronary-syndrome-and-multiple-coronary-atherosclerosis
#13
V I Ganyukov, R S Tarasov, Yu N Neverova, N A Kochergin, O L Barbarash, L S Barbarash
AIM: To assess the long-term results of different approaches to treating patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) and multivessel coronary artery disease (MVCAD). SUBJECTS AND METHODS: A total of 150 patients with NSTE ACS, in whom coronary angiography revealed MVCAD, were examined. The patients were divided into 3 groups according to the selected treatment policy: 1) percutaneous coronary intervention (PCI) (n=91 (60.6%)); 2) coronary artery bypass grafting (CABG) (n=40 (26...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28513199/experience-of-exclusion-a-framework-analysis-of-socioeconomic-factors-affecting-cardiac-rehabilitation-participation-among-patients-with-acute-coronary-syndrome
#14
Maria Pedersen, Dorthe Overgaard, Ingelise Andersen, Marie Baastrup, Ingrid Egerod
BACKGROUND: The Danish public healthcare system provides comprehensive care based on the principle of equal access. However, it is well documented that patients with low socioeconomic position are less likely to participate in cardiac rehabilitation. More knowledge is needed to understand this phenomenon. The aim of the study was to explore the patient experience of barriers to completion of phase II cardiac rehabilitation, and to investigate the impact of socioeconomic factors on completion of cardiac rehabilitation...
May 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28511718/simultaneous-development-of-kawasaki-disease-following-acute-human-adenovirus-infection-in-monozygotic-twins-a-case-report
#15
Sayaka Fukuda, Shuichi Ito, Maya Fujiwara, Jun Abe, Nozomu Hanaoka, Tsuguto Fujimoto, Hiroshi Katsumori
BACKGROUND: The etiology of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and/or some infectious agents underlie the onset of KD. Previous studies have suggested that human adenovirus (HAdV) is one of the triggering pathogens of KD. Here, we report monozygotic twin boys who sequentially developed KD in conjunction with acute HAdV type 3 (HAdV-3) infection. CASE PRESENTATION: The patients were four-year-old monozygotic twin boys...
May 16, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28511435/agreement-and-correlation-between-arterial-and-central-venous-blood-gas-following-coronary-artery-bypass-graft-surgery
#16
Masoumeh Esmaeilivand, Alireza Khatony, Gholamreza Moradi, Farid Najafi, Alireza Abdi
INTRODUCTION: Arterial blood sampling, used to assess patients in acute conditions, may result in complications such as thrombosis and embolism. However, it can be replaced by venous blood sampling, but there is a dearth of information on this. AIM: To assess the correlation and agreement between the arterial and central venous blood gases analyses in patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery. MATERIALS AND METHODS: In this cross-sectional study, 100 ICU patients undergoing elective CABG surgery were recruited...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511322/-interaction-between-apob-gene-polymorphism-and-risk-factors-in-coronary-heart-disease-patients-without-lipid-lowering-treatment
#17
T Pu, H Y Yu, M Xu, Y Zhang, H Yan, L J Sun, W X Xu, Y Y Zhang, W Gao
Objective: To investigate the association between APOB gene R532W polymorphism and the risk of coronary heart disease (CHD) in patients without lipid-lowering treatment and to analyze the interactions between the variation of R532W and different risk factors of CHD. Methods: CHD and non-CHD were diagnosed according to coronary artery angiography (CAG) and/or coronary computed tomography angiogram (CTA) results, as well as clinical features. Blood samples from 771 CHD patients and 772 age- and sex-matched non-CHD controls, who never accepted any lipid-lowering treatments, were collected...
May 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28507572/transient-dilutional-acidosis-but-no-lactic-acidosis-upon-cardiopulmonary-bypass-in-patients-undergoing-coronary-artery-bypass-grafting
#18
Johanna Katharina Teloh, Daniel-Sebastian Dohle, Serhat Sönmez, Konstantinos Tsagakis, Rabea Verhaegh, Miriam Petersen, Heinz Jakob, Herbert de Groot
INTRODUCTION: Dilutional acidosis may result from the introduction of a large fluid volume into the patients' systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial pressure. Its significance or even existence, however, has been strongly questioned. Blood gas samples of patients operated on with standard cardiopulmonary bypass (CPB) were analyzed in order to provide further evidence for the existence of dilutional acidosis...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28507569/effects-of-a-novel-ascorbate-based-protocol-on-infarct-size-and-ventricle-function-in-acute-myocardial-infarction-patients-undergoing-percutaneous-coronary-angioplasty
#19
Cristóbal Ramos, Roberto Brito, Jaime González-Montero, Nicolás Valls, Juan G Gormaz, Juan C Prieto, Rubén Aguayo, Ángel Puentes, Viviana Noriega, Gonzalo Pereira, Tamara Palavecino, Ramón Rodrigo
INTRODUCTION: This study was designed to test the hypothesis that high-dose ascorbate prior to reperfusion followed by low chronic oral doses ameliorate myocardial reperfusion injury (MRI) in acute myocardial infarction patients subjected to primary percutaneous coronary angioplasty (PCA). MATERIAL AND METHODS: A randomized double-blind placebo-controlled and multicenter clinical trial was performed on acute myocardial infarction (AMI) patients who underwent PCA...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28506550/cardioprotective-efficacy-of-sevoflurane-vs-propofol-during-induction-and-or-maintenance-in-patients-undergoing-coronary-artery-revascularization-surgery-without-pump-a-randomized-trial
#20
J L Guerrero Orriach, M Galán Ortega, A Ramirez Fernandez, M Ramirez Aliaga, M I Moreno Cortes, D Ariza Villanueva, A Florez Vela, J Alcaide Torres, C Santiago Fernandez, E Matute Gonzalez, E Alsina Marcos, J J Escalona Belmonte, M Rubio Navarro, L Garrido Sanchez, J Cruz Mañas
PURPOSE: Pre and post-operative administration of sevoflurane in myocardial revascularization surgery provides enhanced cardioprotective effects exerted by pharmacologic pre- and post-conditioning, as compared to propofol. The identification of the enzymes involved in conditioning mechanisms is crucial to the understanding of the effects of sevoflurane in cardiac surgery patients. The impact of sevoflurane on another crucial target organ-the kidney-was also assessed. METHODS: Ninety patients undergoing off-pump myocardial revascularization surgery were allocated to receive either intra- and postoperative sevoflurane (SS), intraoperative sevoflurane and postoperative propofol (SP), or intra- and postoperative propofol (PP))...
May 3, 2017: International Journal of Cardiology
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