Mayuko Ide, Noriko Tabata, Yuko Yonemura, Takayoshi Shirasaki, Kazuhisa Murai, Ying Wang, Atsuya Ishida, Hikari Okada, Masao Honda, Shuichi Kaneko, Nobuhide Doi, Satoru Ito, Hiroshi Yanagawa
Hepatitis B virus (HBV) infection is a major global health problem with no established cure. Dedicator of cytokinesis 11 (DOCK11), known as a guanine nucleotide exchange factor (GEF) for Cdc42, is reported to be essential for the maintenance of HBV. However, potential therapeutic strategies targeting DOCK11 have not yet been explored. We have previously developed an in vitro virus method as a more efficient tool for the analysis of proteomics and evolutionary protein engineering. In this study, using the in vitro virus method, we screened and identified a novel antiasialoglycoprotein receptor (ASGR) antibody, ASGR3-10M, and a DOCK11-binding peptide, DCS8-42A, for potential use in HBV infection...
July 2022: Journal of Biological Chemistry