keyword
https://read.qxmd.com/read/37667569/a-scoping-review-of-oral-language-and-social-communication-abilities-in-children-with-tourette-syndrome
#21
REVIEW
Angela Feehan, Monique Charest
BACKGROUND: Children with Tourette syndrome (TS) have historically experienced problems in academic and social settings, yet their language and communication abilities have not been extensively researched. AIMS: This scoping review maps the literature on the oral language and social communication abilities of children with TS in order to describe the nature of the current literature, present a summary of major findings and identify where gaps exist. METHODS: A scoping review was completed to identify studies measuring the oral language or social communication abilities of children with TS...
September 4, 2023: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/37622808/the-dysfunctional-mechanisms-throwing-tics-structural-and-functional-changes-in-tourette-syndrome
#22
REVIEW
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Gabriella Racchetti, Antonio Malgaroli
Tourette Syndrome (TS) is a high-incidence multifactorial neuropsychiatric disorder characterized by motor and vocal tics co-occurring with several diverse comorbidities, including obsessive-compulsive disorder and attention-deficit hyperactivity disorder. The origin of TS is multifactorial, with strong genetic, perinatal, and immunological influences. Although almost all neurotransmettitorial systems have been implicated in TS pathophysiology, a comprehensive neurophysiological model explaining the dynamics of expression and inhibition of tics is still lacking...
August 10, 2023: Behavioral Sciences
https://read.qxmd.com/read/37620085/tourette-syndrome-and-other-tic-disorders-of-childhood
#23
REVIEW
Christelle Nilles, Andreas Hartmann, Emmanuel Roze, Davide Martino, Tamara Pringsheim
Tics are repetitive, patterned, and nonrhythmic movements or vocalizations/audible sounds that are misplaced in context. Phenomenology and characteristics of tics (e.g., premonitory urge, suppressibility) differentiate them from compulsions, stereotypies, functional tic-like behaviors, and other types of hyperkinetic movement disorders. With a prevalence of approximately 1% in school-aged boys, Tourette syndrome (TS) is considered a common childhood-onset neurodevelopmental disorder, defined by the combination of at least two motor tics and at least one phonic tic lasting more than 1 year...
2023: Handbook of Clinical Neurology
https://read.qxmd.com/read/37605207/phosphodiesterase-and-psychiatric-disorders-a-two-sample-mendelian-randomization-study
#24
JOURNAL ARTICLE
Miaomiao Jiang, Weiheng Yan, Yuyanan Zhang, Zhe Lu, Tianlan Lu, Dai Zhang, Jun Li, Lifang Wang
BACKGROUND: Phosphodiesterases (PDEs) have been associated with psychiatric disorders in observational studies; however, the causality of associations remains unestablished. METHODS: Specifically, cyclic nucleotide PDEs were collected from genome-wide association studies (GWASs), including PDEs obtained by hydrolyzing both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) (PDE1A, PDE2A, and PDE3A), specific to cGMP (PDE5A, PDE6D, and PDE9A) and cAMP (PDE4D and PDE7A)...
August 21, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37557993/is-adjustment-disorder-genetically-correlated-with-depression-anxiety-or-risk-tolerant-personality-trait
#25
JOURNAL ARTICLE
Kazutaka Ohi, Daisuke Fujikane, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Shunsuke Sugiyama, Toshiki Shioiri
Adjustment disorder has three main subtypes: adjustment disorder with depressed mood, adjustment disorder with anxiety, and adjustment disorder with disturbance of conduct. The disorder is moderately heritable and has lifetime comorbidities with major depressive disorder (MDD), anxiety disorders, or risk-tolerant personality. However, it remains unclear whether the degrees of genetic correlations between adjustment disorder and other psychiatric disorders and intermediate phenotypes are similar or different to those between MDD, anxiety disorders or risk-tolerant personality and these other psychiatric disorders and intermediate phenotypes...
August 7, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/37544859/factors-associated-with-tourette-syndrome-among-adolescents-in-taiwan-a-cross-sectional-correlational-study
#26
JOURNAL ARTICLE
Che-Sheng Ho, Yi-Chang Chen, Mei-Yin Lee, Chen-Jung Chen, Huang-Ju Tsai
PURPOSE: Adolescents with Tourette syndrome (TS) may suffer from learning difficulties (attention-deficit/hyperactivity disorder), challenges in interpersonal interactions (especially with peers), disruptions of daily routines (disruptive behavior disorders), and increased psychosocial stress, which can result in internalizing and externalizing behavioral problems, such as venting depression and stress through self-harm. The aim of this study was to investigate peer attachment in adolescents with TS and associated risk factors...
August 5, 2023: Journal of Pediatric Nursing
https://read.qxmd.com/read/37543051/a-systematic-review-of-cannabidiol-trials-in-neurodevelopmental-disorders
#27
REVIEW
Nina-Francecsa Parrella, Aron Thomas Hill, Peter Gregory Enticott, Pamela Barhoun, Isabella Simone Bower, Talitha Caitlyn Ford
Cannabis-derived compounds, such as cannabidiol (CBD) and delta-9-trans-tetrahydrocannabinol (THC), are increasingly prescribed for a range of clinical indications. These phyto-cannabinoids have multiple biological targets, including the body's endocannabinoid system. There is growing scientific interest in the use of CBD, a non-intoxicating compound, to ameliorate symptoms associated with neurodevelopmental disorders. However, its suitability as a pharmaceutical intervention has not been reliably established in these clinical populations...
September 2023: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/37517703/transcranial-magnetic-stimulation-across-the-lifespan-impact-of-developmental-and-degenerative-processes
#28
REVIEW
Lindsay M Oberman, Alberto Benussi
Transcranial magnetic stimulation (TMS) has emerged as a pivotal noninvasive technique for investigating cortical excitability and plasticity across the lifespan, offering valuable insights into neurodevelopmental and neurodegenerative processes. In this review, we explore the impact of TMS applications on our understanding of normal development, healthy aging, neurodevelopmental disorders, and adult-onset neurodegenerative diseases. By presenting key developmental milestones and age-related changes in TMS measures, we provide a foundation for understanding the maturation of neurotransmitter systems and the trajectory of cognitive functions throughout the lifespan...
July 29, 2023: Biological Psychiatry
https://read.qxmd.com/read/37468536/compulsive-sexual-behavior-and-paraphilic-interests-in-adults-with-chronic-tic-disorders-and-tourette-syndrome-a-survey-based-study
#29
JOURNAL ARTICLE
Lille Kurvits, Safiye Tozdan, Tina Mainka, Alexander Münchau, Kirsten R Müller-Vahl, Andrea E Cavanna, Peer Briken, Christos Ganos
Early research suggested that compulsive sexual behavior (CSB) and paraphilic interests (PI) are more prevalent in adults with primary tic disorders compared to the general population. However, recent data on this topic remain scarce. We conducted an anonymous online survey capturing data on CSB and PI in adult patients with primary tic disorders. We also explored the role of antipsychotic tic medication and the impact of neuropsychiatric comorbidities like attention-deficit hyperactivity disorder and depression...
July 19, 2023: International Journal of Impotence Research
https://read.qxmd.com/read/37421881/neurodevelopmental-versus-functional-tics-a-controlled-study
#30
JOURNAL ARTICLE
Andrea E Cavanna, Giulia Purpura, Anna Riva, Renata Nacinovich, Stefano Seri
BACKGROUND: An unprecedented increase in newly developed functional tics, mainly in young females, has been reported during the COVID-19 pandemic. We set out to complement existing case series with the largest controlled study to date on the clinical phenomenology of functional tics versus neurodevelopmental tics. METHODS: Data from 166 patients were collected at a specialist clinic for tic disorders during a three-year period overlapping with the COVID-19 pandemic (2020-2023)...
August 15, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37359272/fine-motor-skills-in-children-with-tourette-syndrome-and-their-unaffected-first-degree-siblings
#31
JOURNAL ARTICLE
Marie Louise Boeg Tygesen, Katrine Maigaard, Julie Hagstrøm, Liselotte Skov, Kerstin Jessica Plessen, Nanette Marinette Monique Debes
BACKGROUND: The exact etiology of Tourette Syndrome (TS) remains unclear, making the search for impaired neuropsychological functions possibly connected to the underlying cause of TS as important as it is challenging. One neuropsychological domain of interest is fine motor skills. METHOD: This study compared fine motor skill performance on the Purdue Pegboard Task (PPT) in 18 children with TS, 24 unaffected first-degree siblings and 20 controls. A set of screening questionnaires was administered to determine comorbid psychiatric illness...
January 2023: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology
https://read.qxmd.com/read/37332633/premonitory-urge-and-tic-severity-comorbidities-and-quality-of-life-in-chronic-tic-disorders
#32
JOURNAL ARTICLE
Valerie Brandt, Jana Essing, Ewgeni Jakubovski, Kirsten Müller-Vahl
BACKGROUND: Tics are intimately associated with premonitory urges (PU) but knowledge about urges is still limited, with small sample sizes often limiting the generalizability of findings. OBJECTIVES: This study addressed the following open questions: (1) is tic severity associated with urge severity, (2) how common is relief, (3) which comorbidities are associated with urges, (4) are urges, tics, and comorbidities associated with lower quality of life, and (5) can complex and simple, motor and vocal tics be differentiated based on PU? METHODS: N = 291 patients who reported a confirmed diagnosis of chronic primary tic disorder (age = 18-65, 24% female) filled out an online survey assessing demographic data, comorbid conditions, location, quality and intensity of PU, as well as quality of life...
June 2023: Movement Disorders Clinical Practice
https://read.qxmd.com/read/37295060/childhood-comorbidity-severity-impacts-adolescent-substance-consumption-in-patients-with-tourette-syndrome
#33
JOURNAL ARTICLE
Kaja Andersen, Camilla Groth, Liselotte Skov, Nanette Mol Debes
BACKGROUND: This study explores the longitudinal impact of severity of Tourette Syndrome (TS), diagnosis and severity of Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD), and guardian socioeconomic status on the level of substance use of pediatric patients with TS. METHODS: A total of 314 pediatric patients with TS participated at time 1 (T1). During these visits, the severity of the patients' TS, ADHD, and OCD symptoms were assessed, along with their guardians' socioeconomic status...
May 16, 2023: Pediatric Neurology
https://read.qxmd.com/read/37294231/bilateral-globus-pallidus-externus-deep-brain-stimulation-for-the-treatment-of-refractory-tourette-syndrome-an-open-clinical-trial
#34
JOURNAL ARTICLE
Osvaldo Vilela-Filho, Joaquim T Souza, Paulo C Ragazzo, Délson J Silva, Paulo M Oliveira, Lissa C Goulart, Manoel D Reis, Fabian Piedimonte, Telma M Ribeiro
OBJECTIVES: We have previously proposed that Tourette syndrome (TS) is the clinical expression of the hyperactivity of globus pallidus externus (GPe) and various cortical areas. This study was designed to test this hypothesis by verifying the efficacy and safety of bilateral GPe deep brain stimulation (DBS) for treating refractory TS. MATERIALS AND METHODS: In this open clinical trial, 13 patients were operated on. Target coordinates (center of GPe) were obtained by direct visualization...
June 7, 2023: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/37246931/early-life-and-family-risk-factors-for-tic-disorder-persistence-into-adulthood
#35
JOURNAL ARTICLE
David Mataix-Cols, Kayoko Isomura, Gustaf Brander, Isabell Brikell, Paul Lichtenstein, Zheng Chang, Henrik Larsson, Ralf Kuja-Halkola, Kevin J Black, Anna Sidorchuk, Lorena Fernández de la Cruz
BACKGROUND: Many children with tic disorders outgrow their tics, but little is known about the proportion of individuals who will continue to require specialist services in adulthood and which variables are associated with tic persistence. OBJECTIVES: The aims were to estimate the proportion of individuals first diagnosed with tic disorders in childhood who continued to receive tic disorder diagnoses after age 18 years and to identify risk factors for persistence...
May 29, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/37209130/what-distinguishes-patients-with-mass-social-media-induced-illness-presenting-with-tourette-like-behavior-from-those-with-tourette-syndrome-results-of-a-prospective-cohort-study
#36
JOURNAL ARTICLE
Carolin Fremer, Natalia Szejko, Anna Pisarenko, Martina Haas, Luise Laudenbach, Claudia Wegener, Kirsten R Müller-Vahl
Since 2019, a global increase in patients presenting with functional Tourette-like behaviors (FTB) has been observed. This has been related to the exposure of tic-related content in social media, although other factors seem to further fuel this phenomenon. Recently, we, therefore, proposed the term mass social media-induced illness (MSMI) as, in our opinion, this phenomenon constitutes a new type of mass sociogenic illness (MSI) that is in contrast to all recent outbreaks spread solely via social media. In accordance with this hypothesis, we were able to identify the host of the German YouTube channel "Gewitter im Kopf" ("Thunderstorm in the brain") as the initial virtual index case...
May 20, 2023: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/37202553/genetic-patterning-for-child-psychopathology-is-distinct-from-that-for-adults-and-implicates-fetal-cerebellar-development
#37
JOURNAL ARTICLE
Dylan E Hughes, Keiko Kunitoki, Safia Elyounssi, Mannan Luo, Oren M Bazer, Casey E Hopkinson, Kevin F Dowling, Alysa E Doyle, Erin C Dunn, Hamdi Eryilmaz, Jodi M Gilman, Daphne J Holt, Eve M Valera, Jordan W Smoller, Charlotte A M Cecil, Henning Tiemeier, Phil H Lee, Joshua L Roffman
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores...
June 2023: Nature Neuroscience
https://read.qxmd.com/read/37196601/moderating-role-of-depression-on-the-association-of-tic-severity-with-functional-impairment-in-children
#38
JOURNAL ARTICLE
Dana Feldman Sadeh, Mira Levis Frenk, Tomer Simha, Danny Horesh, Tamar Steinberg, Nofar Geva, Matan Nahon, Andrea Dietrich, Pieter J Hoekstra, Daphna Ruhrman, Alan Apter, Silvana Fennig, Noa Benaroya-Milshtein
BACKGROUND: Chronic tic disorders (CTDs) commonly co-occur with other psychiatric disorders. CTDs have been linked to functional impairment and reduction in quality of life. Insufficient research is available on depressive symptoms in patients with CTD, especially children and adolescents, yielding conflicting findings. To investigate the presence of depressive symptoms in a cohort of children and young adolescents with CTD and to test whether they moderate the link between tic severity and functional impairment...
April 21, 2023: Pediatric Neurology
https://read.qxmd.com/read/37104813/beyond-the-rubicon-a-continuum-approach-to-investigating-the-impact-of-adhd-like-characteristics-on-everyday-executive-function-in-children-with-tourette-syndrome
#39
JOURNAL ARTICLE
Colin J Hamilton, Karen Harrison
Across a range of neurodevelopmental conditions, a diagnosis of attention deficit hyperactivity disorder (ADHD) has been shown to be associated with executive function impairment. However, the DSM-V emphasis upon viewing psychological characteristics as existing on a continuous distributed quantitative dimension has enabled the opportunity to consider the influence of sub-diagnostic or sub-referral levels of these psychological characteristics upon cognitive function. This study adopted a continuum approach to the consideration of this ADHD influence and examined the extent to which the difference in parental reported executive functions between children with Tourette syndrome (TS) or typically developing children could be mediated by a concurrent group difference in the possession of sub-referral levels of ADHD-like characteristics...
April 27, 2023: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://read.qxmd.com/read/37089074/dimensional-assessment-of-depression-and-anxiety-in-a-clinical-sample-of-adults-with-chronic-tic-disorder
#40
JOURNAL ARTICLE
David A Isaacs, Ashruta Narapareddy, Michelle R Eckland, Heather R Riordan
OBJECTIVE: Among adults with Tourette syndrome, depression and anxiety symptoms are widely prevalent and consistently associated with poor quality of life. Important knowledge gaps remain regarding mood and anxiety dimensions of the adult Tourette syndrome phenotype. Taking a dimensional approach, this study sought to determine the prevalence, severity, and clinical correlates of depression and anxiety symptoms in a clinical sample of adults with Tourette syndrome and other chronic tic disorders...
April 24, 2023: Journal of Neuropsychiatry and Clinical Neurosciences
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