Dylan E Hughes, Keiko Kunitoki, Safia Elyounssi, Mannan Luo, Oren M Bazer, Casey E Hopkinson, Kevin F Dowling, Alysa E Doyle, Erin C Dunn, Hamdi Eryilmaz, Jodi M Gilman, Daphne J Holt, Eve M Valera, Jordan W Smoller, Charlotte A M Cecil, Henning Tiemeier, Phil H Lee, Joshua L Roffman
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores...
June 2023: Nature Neuroscience