Mengjiao Wang, Quan Wan, Chenglv Wang, Qianyu Jing, Yujie Nie, Xiangyan Zhang, Xin Chen, De Yang, Runsang Pan, Linzhao Li, Lan Zhu, Huan Gui, Shuanghui Chen, Yuezhen Deng, Tao Chen, Yingjie Nie
Immunotherapy is regarded as a potent cancer treatment, with DC vaccines playing a crucial role. Although clinical trials have demonstrated the safety and efficacy of DC vaccines, loading antigens in vitro is challenging, and their therapeutic effects remain unpredictable. Moreover, the diverse subtypes and maturity states of DCs in the body could induce both immune responses and immune tolerance, potentially affecting the vaccine's efficacy. Hence, the optimization of DC vaccines remains imperative. Our study discovered a new therapeutic strategy by using CT26 and MC38 mouse colon cancer models, as well as LLC mouse lung cancer models...
March 20, 2024: Molecular and Cellular Biochemistry