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Dopamine and stroke

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https://www.readbyqxmd.com/read/28153639/parkinson-s-disease-alters-multisensory-perception-insights-from-the-rubber-hand-illusion
#1
Catherine Ding, Colin J Palmer, Jakob Hohwy, George J Youssef, Bryan Paton, Naotsugu Tsuchiya, Julie C Stout, Dominic Thyagarajan
BACKGROUND: Manipulation of multisensory integration induces illusory perceptions of body ownership. Patients with Parkinson's disease (PD), a neurodegenerative disorder characterised by striatal dopamine deficiency, are prone to illusions and hallucinations and have sensory deficits. Dopaminergic treatment also aggravates hallucinations in PD. Whether multisensory integration in body ownership is altered by PD is unexplored. OBJECTIVE: To study the effect of dopamine neurotransmission on illusory perceptions of body ownership...
January 31, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28151554/activity-dependent-modulation-of-intracellular-atp-in-cultured-cortical-astrocytes
#2
Ulrike Winkler, Pauline Seim, Yvonne Enzbrenner, Susanne Köhler, Marit Sicker, Johannes Hirrlinger
Brain function is absolutely dependent on an appropriate supply of energy. A shortfall in supply-as occurs, for instance, following stroke-can lead rapidly to irreversible damage to this vital organ. While the consequences of pathophysiological energy depletion have been well documented, much less is known about the physiological energy dynamics of brain cells, although changes in the intracellular concentration of adenosine triphosphate (ATP), the major energy carrier of cells, have been postulated to contribute to cellular signaling...
February 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28117941/donor-preconditioning-after-the-onset-of-brain-death-with-dopamine-derivate-n-octanoyl-dopamine-improves-early-posttransplant-graft-function-in-the-rat
#3
Shiliang Li, Sevil Korkmaz-Icöz, Tamás Radovits, Mihály Ruppert, Rahel Spindler, Sivakkanan Loganathan, Péter Hegedűs, Paige Brlecic, Bastian Theisinger, Sonja Theisinger, Simone Höger, Maik Brune, Felix Lasitscha, Matthias Karck, Benito Yard, Gábor Szabó
Heart transplantation is the therapy of choice for end-stage heart failure. However, hemodynamic instability, which has been demonstrated in brain-dead donors (BDD), could also affect the posttransplant graft function. We tested the hypothesis that treatment of the BDD with the dopamine derivate n-octanoyl-dopamine (NOD) improves donor cardiac and graft function after transplantation. Donor rats were given a continuous intravenous infusion of either NOD (0.882mg/kg/h, BDD+NOD, n=6) or a physiological saline vehicle (BDD, n=9) for 5h after the induction of brain death by inflation of a subdural balloon catheter...
January 24, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28076681/computational-modeling-of-neurotransmitter-release-evoked-by-electrical-stimulation-nonlinear-approaches-to-predicting-stimulation-evoked-dopamine-release
#4
James K Trevathan, Ali Yousefi, Hyung Ook Park, John J Bartoletta, Kip A Ludwig, Kendall H Lee, J Luis Lujan
Neurochemical changes evoked by electrical stimulation of the nervous system have been linked to both therapeutic and undesired effects of neuromodulation therapies used to treat obsessive-compulsive disorder, depression, epilepsy, Parkinson's disease, stroke, hypertension, tinnitus, and many other indications. In fact, interest in better understanding the role of neurochemical signaling in neuromodulation therapies has been a focus of recent government- and industry-sponsored programs whose ultimate goal is to usher in an era of personalized medicine by creating neuromodulation therapies that respond to real-time changes in patient status...
February 6, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28000548/hypertensive-crisis-pharmacotherapy-and-complications
#5
Priyanka Wani-Parekh, Carlos Garcia-Blanco, Melissa Mendez, Debabrata Mukherjee
Cardiovascular diseases (CVD) are the number one cause of death globally compared to any other cause. CVD accounts for approximately 17.3 million deaths per year and are rising. Hypertension is the leading risk factor for cardiovascular diseases. Approximately 80 million people suffer from hypertension in the U.S. While, majority of these individuals are on antihypertensive medications only 54% of individuals with hypertension are optimally controlled. Heart failure and stroke are some of the devastating complications of uncontrolled hypertension...
December 20, 2016: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#6
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27926449/the-role-of-dopamine-in-the-pathophysiology-and-treatment-of-apathy
#7
T T-J Chong, M Husain
Disorders of diminished motivation, such as apathy, are common and prevalent across a wide range of medical conditions, including Parkinson's disease, Alzheimer's dementia, stroke, depression, and schizophrenia. Such disorders have a significant impact on morbidity and quality of life, yet their management lacks consensus and remains unsatisfactory. Here, we review laboratory and clinical evidence for the use of dopaminergic therapies in the treatment of apathy. Dopamine is a key neurotransmitter that regulates motivated decision making in humans and other species...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27859794/the-perception-of-affective-touch-in-parkinson-s-disease-and-its-relation-to-small-fibre-neuropathy
#8
Lewis Kass-Iliyya, Matthew Leung, Andrew Marshall, Paula Trotter, Christopher Kobylecki, Susannah Walker, David Gosal, Maria Jeziorska, Rayaz A Malik, Francis McGlone, Monty A Silverdale
Affective touch sensation is conducted by a sub-class of C-fibres in hairy skin known as C-Tactile (CT) afferents. CT afferents respond maximally to gentle skin stroking at velocities between 1 and 10 cm/s. Parkinson's disease (PD) is characterised by markedly reduced cutaneous C-fibres. It is not known if affective touch perception is influenced by C-fibre density and if affective touch is impaired in PD compared to healthy controls. We predicted that perceived pleasantness to gentle stroking in PD would correlate with C-afferent density and that affective touch perception would be impaired in PD compared to healthy controls...
January 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27724964/sinomenine-activates-astrocytic-dopamine-d2-receptors-and-alleviates-neuroinflammatory-injury-via-the-cryab-stat3-pathway-after-ischemic-stroke-in-mice
#9
Jing Qiu, Zhongjun Yan, Kai Tao, Yansong Li, Yuqian Li, Jingchen Li, Yushu Dong, Dayun Feng, Huisheng Chen
BACKGROUND: Astrocyte-mediated neuroinflammation plays a critical role in ischemic stroke-induced secondary cerebral injury. Previous studies have suggested that the dopamine D2 receptor (DRD2) acts as a key target in regulating the neuroinflammatory response. However, the underlying molecular mechanisms are still unknown, and effective DRD2 agonists are lacking. In the present study, we examined the anti-inflammatory and neuroprotective effects of sinomenine (Sino), a monomeric compound with potential immunoregulatory properties in nervous system...
October 10, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27689550/association-between-genetic-variation-in-the-dopamine-system-and-motor-recovery-after-stroke
#10
Bo-Ram Kim, Hahn Young Kim, Young Il Chun, Yeo-Min Yun, Hyuntae Kim, Dong-Hee Choi, Jongmin Lee
BACKGROUND: The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity for recovery after stroke, limited studies have investigated the effects of polymorphism of dopamine-related genes. OBJECTIVE: We aimed to investigate the association between motor recovery in stroke patients and polymorphisms in the dopamine-related genes catechol-O-methyltransferase (COMT), dopamine receptor D1 (DRD1), DRD2, and DRD3...
September 29, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27687032/impact-of-bromocriptine-qr-therapy-on-cardiovascular-outcomes-in-type-2-diabetes-mellitus-subjects-on-metformin
#11
RANDOMIZED CONTROLLED TRIAL
Bindu Chamarthi, Michael Ezrokhi, Dean Rutty, Anthony H Cincotta
OBJECTIVES: Type 2 diabetes mellitus (T2DM) is associated with a substantially increased risk of cardiovascular disease (CVD). Bromocriptine-QR (B-QR), a quick release sympatholytic dopamine D2 receptor agonist, is a FDA-approved therapy for T2DM which may provide CVD risk reduction. Metformin is considered to be an agent with a potential cardioprotective benefit. This large placebo controlled clinical study assessed the impact of B-QR addition to existing metformin therapy on CVD outcomes in T2DM subjects...
November 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27579957/a-review-and-conceptual-model-of-dopaminergic-contributions-to-poststroke-depression
#12
Ansley Stanfill, Lucas Elijovich, Brandon Baughman, Yvette Conley
About one third of all patients recovering from stroke will experience some degree of poststroke depression (PSD). PSD lengthens recovery times and reduces overall quality of life for these individuals. Although demographic, environmental, and clinical factors may explain some of the variability seen, these factors cannot fully predict the development of PSD. Furthermore, the precise mechanism of action is largely unknown. Recent work has begun to shed light on the influence of the monoamine neurotransmitter dopamine...
October 2016: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/27324898/protein-profile-and-morphological-alterations-in-penumbra-after-focal-photothrombotic-infarction-in-the-rat-cerebral-cortex
#13
Anatoly Uzdensky, Svetlana Demyanenko, Grigory Fedorenko, Tayana Lapteva, Alexej Fedorenko
After ischemic stroke, cell damage propagates from infarct core to surrounding tissues (penumbra). To reveal proteins involved in neurodegeneration and neuroprotection in penumbra, we studied protein expression changes in 2-mm ring around the core of photothrombotic infarct induced in the rat brain cortex by local laser irradiation after administration of Bengal Rose. The ultrastructural study showed edema and degeneration of neurons, glia, and capillaries. Morphological changes gradually decreased across the penumbra...
June 21, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27320243/pharmacological-hypothermia-a-potential-for-future-stroke-therapy
#14
REVIEW
Kaiyin Liu, Hajra Khan, Xiaokun Geng, Jun Zhang, Yuchuan Ding
Mild physical hypothermia after stroke has been associated with positive outcomes. Despite the well-studied beneficial effects of hypothermia in the treatment of stroke, lack of precise temperature control, intolerance for the patient, and immunosuppression are some of the reasons which limit its clinical translation. Pharmacologically induced hypothermia has been explored as a possible treatment option following stroke in animal models. Currently, there are eight classes of pharmacological agents/agonists with hypothermic effects affecting a multitude of systems including cannabinoid, opioid, transient receptor potential vanilloid 1 (TRPV1), neurotensin, thyroxine derivatives, dopamine, gas, and adenosine derivatives...
June 2016: Neurological Research
https://www.readbyqxmd.com/read/27251297/neuroanatomic-pathways-associated-with-monoaminergic-dysregulation-after-stroke
#15
Seiji Hama, Taro Murakami, Hidehisa Yamashita, Keiichi Onoda, Shigeto Yamawaki, Kaoru Kurisu
OBJECTIVE: We examined the complex relationship between lesion location, symptoms of depression (affective and apathetic), and monoamine dysfunction after stroke. METHODS: Magnetic resonance imaging was performed on 48 post-stroke patients that had been assessed for affective and apathetic symptoms using the Hospital Anxiety and Depression Scale and the Apathy Scale, respectively. Noradrenalin (NA), dopamine (DA), their metabolites, and a metabolite of serotonin (5-HT) were measured using 24-h urine samples, and 5-HT and 3-methoxy-4-hydroxyphenylglycol were measured using blood samples...
June 1, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27150829/effects-of-commonly-used-inotropes-on-myocardial-function-and-oxygen-consumption-under-constant-ventricular-loading-conditions
#16
Elizabeth S DeWitt, Katherine J Black, Ravi R Thiagarajan, James A DiNardo, Steven D Colan, Francis X McGowan, John N Kheir
Inotropic medications are routinely used to increase cardiac output and arterial blood pressure during critical illness. However, few comparative data exist between these medications, particularly independent of their effects on venous capacitance and systemic vascular resistance. We hypothesized that an isolated working heart model that maintained constant left atrial pressure and aortic blood pressure could identify load-independent differences between inotropic medications. In an isolated heart preparation, the aorta and left atrium of Sprague Dawley rats were cannulated and placed in working mode with fixed left atrial and aortic pressure...
July 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27022346/the-relationship-between-hba1c-atrial-fibrillation-after-off-pump-coronary-artery-bypass-surgery-in-diabetic-patients
#17
Suleyman Surer, Mustafa Seren, Onur Saydam, Ali Bulut, Ugursay Kiziltepe
OBJECTIVE: Diabetes mellitus is recognized as a risk factor for mortality and morbidity after coronary bypass grafting. We aimed to determine the association between preoperative hemoglobin HbA1c and AF after isolated off-pump coronary bypass grafting (OPCAB). METHODS: The seventy-two diabetic patients undergoing isolated off-pump coronary bypass grafting were retrospectively analyzed for AF. They were divided into; Low (4.8-5.4%), Medium (5.5-8%) and High (8.1-11...
January 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26979720/citicoline-retards-myopia-progression-following-form-deprivation-in-guinea-pigs
#18
Junfeng Mao, Shuangzhen Liu, Chunyan Fu
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and deprived + vehicle groups...
June 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26968905/dehydroascorbic-acid-for-the-treatment-of-acute-ischemic-stroke
#19
Reynold Spector
In animal models of acute ischemic stroke, intravenous dehydroascorbic acid (DHAA), unlike ascorbic acid (AA), readily enters brain and is converted in both normal and ischemic brain into protective ascorbic acid. When given parenterally DHAA minimizes infarct volume and facilitates functional recovery. I hypothesize the same effect will occur in humans with acute ischemic stroke. Efficacy in reducing infarct volume is demonstrable in mice and rats even when DHAA is infused three hours after the experimental infarct...
April 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26872985/effects-of-a-prostagrandin-ep4-receptor-agonist-ono-ae1-329-on-the-left-ventricular-pressure-volume-relationship-in-the-halothane-anesthetized-dogs
#20
Atsushi Honda, Yuji Nakamura, Hiroshi Ohara, Xin Cao, Hiroaki Nomura, Jun Katagi, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama
Cardiac effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 were assessed in the halothane-anesthetized dogs under the monitoring of left ventricular pressure-volume relationship, which were compared with those of clinically recommended doses of dopamine, dobutamine and milrinone (n=4-5 for each treatment). ONO-AE1-329 was intravenously administered in doses of 0.3, 1 and 3 ng/kg/min for 10 min with a pause of 20 min. Dopamine in a dose of 3 µg/kg/min for 10 min, dobutamine in a dose of 1 µg/kg/min for 10 min and milrinone in a dose of 5 µg/kg/min for 10 min followed by 0...
March 15, 2016: European Journal of Pharmacology
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