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https://www.readbyqxmd.com/read/29169168/anterior-borderzone-angle-for-hemodynamic-collateral-metric-in-patients-with-symptomatic-middle-cerebral-artery-stenosis
#1
Yongkun Li, Yunyun Xiong, Qiankun Cai, Dezhi Liu, Qiliang Dai, Wenhua Liu, Zhixin Huang, Wen Sun, David S Liebeskind, Yinzhou Wang, Xinfeng Liu
BACKGROUND AND AIMS: We aimed to introduce a parameter of anterior borderzone angle (ABZA) to quantitatively evaluate the ACA-MCA leptomeningeal collaterals for middle cerebral artery stenosis (MCAS). METHODS: Two hundred seventy-five patients with 50-100% MCAS and 100 controls were included. The 95% reference range of ABZA was obtained from the controls. ABZAtrans was defined as "ABZA/the 95% upper limit." Relationships between ABZA and MCAS, -ABZAtrans and the TICI grade, the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) collateral grade were analyzed...
November 23, 2017: European Neurology
https://www.readbyqxmd.com/read/29150867/near-infrared-diffuse-reflectance-signals-for-monitoring-spreading-depolarizations-and-progression-of-the-lesion-in-a-male-rat-focal-cerebral-ischemia-model
#2
Satoko Kawauchi, Izumi Nishidate, Hiroshi Nawashiro, Shunichi Sato
In ischemic stroke research, a better understanding of the pathophysiology and development of neuroprotection methods are crucial, for which in vivo imaging to monitor spreading depolarizations (SDs) and evolution of tissue damage is desired. Since these events are accompanied by cellular morphological changes, light-scattering signals, which are sensitive to cellular and subcellular morphology, can be used for monitoring them. In this study, we performed transcranial imaging of near-infrared (NIR) diffuse reflectance at ∼800 nm, which sensitively reflects light-scattering change, and examined how NIR reflectance is correlated with simultaneously measured cerebral blood flow (CBF) for a rat middle cerebral artery occlusion (MCAO) model...
November 18, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29148900/combined-interventional-and-surgical-treatment-of-tandem-middle-cerebral-artery-embolus-and-internal-carotid-artery-occlusion-case-report
#3
Mark B Frenkel, Jaclyn J Renfrow, Jasmeet Singh, Nitin Garg, Stacey Q Wolfe
Tandem internal carotid artery (ICA) origin occlusion and middle cerebral artery (MCA) thromboembolism is a life-threatening condition with poor neurological outcome. The authors report on a patient presenting with acute ischemic stroke from a tandem ICA and MCA occlusion with penumbra. Emergency MCA mechanical thrombectomy was performed through percutaneous cervical ICA access due to the inability to cross the cervical carotid occlusion. Emergency carotid endarterectomy to reperfuse the poorly collateralized hemisphere and repair the ICA access site was performed 2 hours after completion of tissue plasminogen activator (tPA) infusion...
November 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29145041/transradial-access-for-cerebrovascular-angiography-evaluation-of-palmar-collateral-circulation-with-hand-angiography-and-its-correlation-with-allen-test
#4
Woo-Keun Kwon, Wonki Yoon, Taek-Hyun Kwon, Jong Hyun Kim, Heung-Sub Jung, Jaegeun Ahn, Hanyong Huh, Choel Ji
OBJECTIVES: Transradial cerebral angiography (TRCA) has been introduced as an alternative technique for the transfemoral access, and its use is becoming more common in the field. In this study, we retrospectively analyzed a group of patients who received TRCA, and investigated peri-procedural measurements indicating actual hand circulation, and studied their correlation with the Allen test. PATIENTS AND METHODS: A retrospective review of 168 patients whom underwent TRCA between 2015 July and 2016 July, were included in this study...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29135347/relative-cerebral-blood-volume-is-associated-with-collateral-status-and-infarct-growth-in-stroke-patients-in-swift-prime
#5
Juan F Arenillas, Elisa Cortijo, Pablo García-Bermejo, Elad I Levy, Reza Jahan, Mayank Goyal, Jeffrey L Saver, Gregory W Albers
We aimed to evaluate how predefined candidate cerebral perfusion parameters correlate with collateral circulation status and to assess their capacity to predict infarct growth in patients with acute ischemic stroke (AIS) eligible for endovascular therapy. Patients enrolled in the SWIFT PRIME trial with baseline computed tomography perfusion (CTP) scans were included. RAPID software was used to calculate mean relative cerebral blood volume (rCBV) in hypoperfused regions, and hypoperfusion index ratio (HIR). Blind assessments of collaterals were performed using CT angiography in the whole sample and cerebral angiogram in the endovascular group...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29114317/agenesis-of-the-internal-carotid-artery-with-transcavernous-anastomosis-associated-with-anterior-communicating-artery-aneurysms
#6
Kosuke Kumagai, Satoru Takeuchi, Naoki Otani, Masaki Komiyama, Kentaro Mori
Agenesis of the internal carotid artery (ICA) is a rare congenital anomaly. Recently, several cases of ICA agenesis have been associated with cerebral aneurysms. We present the seventh case of ICA agenesis with transcavernous anastomosis associated with cerebral aneurysms. A 47-year-old man presented with transient numbness of his left hand. Magnetic resonance angiography indicated the presence of anterior communicating artery (ACoA) aneurysms. Digital subtraction angiography revealed two ACoA aneurysms, absence of the left ICA, and an anomalous collateral vessel connecting the cavernous portions of both internal carotid arteries, which was considered to be a transcavernous anastomosis...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29114304/thrombosed-giant-true-posterior-communicating-artery-aneurysm-treated-by-trapping-and-thrombectomy
#7
Yuichi Mochizuki, Akitsugu Kawashima, Koji Yamaguch, Yoshikazu Okada
Giant "true" posterior communicating artery (PCOM) aneurysms are rare and the best surgical treatment for them is unclear. We present a case of 85-year-old woman with this type of lesion, 35 mm in diameter, successfully treated by trapping and thrombectomy via pterional approach without complications. There were no perforating arteries originating from the aneurysmal wall. The patient had an uneventful postoperative course. The key for successful treatment for such lesions is preservation of perforators, as trapping may result in ischemic complications...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29113412/collateral-vessels-on-magnetic-resonance-angiography-in-endovascular-treated-acute-ischemic-stroke-patients-associated-with-clinical-outcomes
#8
Liang Jiang, Hao-Bo Su, Ying-Dong Zhang, Jun-Shan Zhou, Wen Geng, Huiyou Chen, Quan Xu, Xindao Yin, Yu-Chen Chen
Purpose: Collateral vessels were considered to be related with outcome in endovascular-treated acute ischemic stroke patients. This study aimed to evaluate whether the collateral vessels on magnetic resonance angiography (MRA) could predict the clinical outcome. Materials and Methods: Acute stroke patients with internal carotid artery or middle cerebral artery occlusion within 6 hours of symptom onset were included. All patients underwent MRI and received endovascular treatment...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096678/minimal-sufficient-balance-randomization-for-sequential-randomized-controlled-trial-designs-results-from-the-escape-trial
#9
Tolulope T Sajobi, Gurbakhshash Singh, Mark W Lowerison, Jordan Engbers, Bijoy K Menon, Andrew M Demchuk, Mayank Goyal, Michael D Hill
BACKGROUND: We describe the implementation of minimal sufficient balance randomization, a covariate-adaptive randomization technique, used for the "Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times" (ESCAPE) trial. METHODS: The ESCAPE trial is a prospective, multicenter, randomized clinical trial that enrolled subjects with the following main inclusion criteria: less than 12 h from symptom onset, age 18 years or older, baseline NIHSS score > 5, ASPECTS score > 5 and computed tomography angiography (CTA) evidence of carotid T/L or M1-segment middle cerebral artery (MCA) occlusion, and at least moderate collaterals by CTA...
November 2, 2017: Trials
https://www.readbyqxmd.com/read/29089414/flow-diversion-for-anterior-choroidal-artery-acha-aneurysms-a-multi-institutional-experience
#10
Visish M Srinivasan, Michael George Zaki Ghali, Jacob Cherian, Maxim Mokin, Ajit S Puri, Ramesh Grandhi, Stephen R Chen, Jeremiah N Johnson, Peter Kan
BACKGROUND: Anterior choroidal artery (AChA) aneurysms represent a small subset of cerebral aneurysms. The Pipeline Embolization Device (PED) has been successfully applied to various aneurysms of the supraclinoid internal carotid artery (ICA). The treatment of these aneurysms requires special attention due to the eloquent territory supplied by the AChA. We report the largest and first dedicated series of flow diversion treatment of AChA aneurysms. METHODS: Four institutional neurointerventional databases were reviewed for cases of intracranial aneurysms treated with PED...
October 31, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29080022/learning-as-a-functional-state-of-the-brain-studies-in-wild-type-and-transgenic-animals
#11
José M Delgado-García, Agnès Gruart
Contemporary neuroscientists are paying increasing attention to subcellular, molecular, and electrophysiological mechanisms underlying learning and memory processes. Recent studies have examined the development of transgenic mice affected at different stages of the learning process, or have emulated in animals various human pathological conditions involving cognition and motor learning. However, a parallel effort is needed to develop stimulating and recording techniques suitable for use in behaving mice in order to understand activity-dependent synaptic changes taking place during the very moment of the learning process...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29071991/-effect-of-electroacupuncture-on-expression-of-apelin-apj-system-of-cerebral-vascular-endothelial-cell-in-rats-with-cerebral-infarction
#12
Li-Hong Yang, Yuan-Hao Du, Jing Li
OBJECTIVE: To observe the regulation of APJ and its ligand Apelin on the angiogenesis pathway after cerebral infarction and the intervention effect of acupuncture. METHODS: Wistar rats were randomly divided into model group(n=90), electroacupuncture(EA) group(n=90), sham operation group(n=90) and control group(n=10). The first three groups were further divided into 1,3,6,9,12,24 h and 3,7, 12 d subgroups(n=10 in each subgroup). The cerebral infarction model was established by middle cerebral artery occlusion (MCAO)...
February 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29071134/solitaire-stent-in-the-treatment-of-acute-ischemic-stroke-with-large-cerebral-artery-occlusion
#13
Wenbao Liang, Zhijie Ou, Rui Luo
OBJECTIVE: To investigate the effect of mechanical thrombectomy with solitaire stent in the treatment of acute ischemic stroke with large cerebral artery occlusion. METHODS: Fifteen acute ischemic stroke patients with a proximal intracranial occlusion in the anterior circulation were included within 6 hours after symptom onset (unknown time of onset allowed in wake upstroke). Patients with a large infarct core or poor collateral circulation on computed tomography (CT) and CT angiography were excluded...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/29068254/assessment-of-clot-length-with-multiphase-ct-angiography-in-patients-with-acute-ischemic-stroke
#14
Vanessa Polito, Roberta La Piana, Maria Del Pilar Cortes, Donatella Tampieri
Introduction Existing stroke literature demonstrates that rapid recanalization of vessels improves long-term prognosis after acute ischemic stroke. However, further optimization of the speed of the thrombectomy procedure, used to recanalize a blocked vessel, is limited by our minimal knowledge of the clot dimensions pre-procedure. Knowing the clot dimensions would allow planning of the thrombectomy procedure with the appropriate size and length of stent retriever, and determination of the correct site of the stent deployment ensuring total coverage of the clot by the stent retriever...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29063266/congenital-absence-of-the-bilateral-internal-carotid-artery-a-review-of-the-associated-ab-normalities-from-a-newborn-status-to-the-eighth-decade-of-life
#15
REVIEW
Ljiljana Vasović, Milena Trandafilović, Slobodan Vlajković, Goran Radenković
PURPOSE: Due to the fact that the internal carotid artery (ICA) is responsible for nourishing two thirds of the brain volume, our aim was to inspect the morphofunctional consequences of the bilateral lack of this artery. METHODS: In order to examine this condition, we referred to both the library archive of our Faculty of Medicine and electronic databases of anatomical and clinical reports that included the following keywords: "absence," "aplasia," or "agenesis" in combination with "internal carotid artery," "common carotid artery," or only "carotid artery...
October 23, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29061453/prevention-of-the-rerupture-of-collateral-artery-aneurysms-on-the-ventricular-wall-by-early-surgical-revascularization-in-moyamoya-disease-report-of-two-cases-and-review-of-the-literature
#16
Fumiaki Kanamori, Syuntaro Takasu, Shinji Ota, Yukio Seki
BACKGROUND: Collateral artery aneurysms are a source of intracranial hemorrhage in moyamoya disease. Several reports have shown that surgical revascularization leads to the obliteration of collateral artery aneurysms. However, its effect on the prevention of rebleeding has not been established, and the optimal timing of the operation remains unclear. The purpose of the present study is to evaluate the effects of surgical revascularization and to investigate the optimal operation timing in patients with moyamoya disease who have ruptured collateral artery aneurysms on the ventricular wall...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29056445/characteristics-of-cerebral-hemodynamics-assessed-by-ct-perfusion-in-moyamoya-disease
#17
Ayaka Sasagawa, Takeshi Mikami, Toru Hirano, Yukinori Akiyama, Nobuhiro Mikuni
Due to the recent development of multidetector row computed tomography (CT), hemodynamic parameters can now be conveniently obtained with CT perfusion. The purpose of this study is to characterize the hemodynamic parameters of CT perfusion in moyamoya disease, and to discuss the differences in collateral circulation between moyamoya disease and atherosclerotic disease. A total of 16 hemispheric sides of 15 patients with moyamoya disease and 10 hemispheric sides of 9 patients with atherosclerotic disease who underwent bypass surgery were included...
October 19, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29053905/distinct-predictive-role-of-collateral-status-on-clinical-outcome-in-variant-stroke-subtypes-of-acute-large-arterial-occlusion
#18
Xuting Zhang, Meixia Zhang, Wenhong Ding, Shenqiang Yan, David S Liebeskind, Min Lou
BACKGROUND: Clinical trials have showed that robust collateral flow has a relationship with good clinical outcome, however, different stroke subtypes were lumped together. This study explored the relationship between baseline collaterals and the onset-to-imaging time (OIT), and the correlation between pre-treatment collateral status and clinical outcome among different subtypes. METHOD: We reviewed prospectively collected data from consecutive acute ischemic stroke (AIS) patients with acute middle cerebral artery occlusion who received reperfusion therapy...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29042296/computations-in-the-deep-vs-superficial-layers-of-the-cerebral-cortex
#19
Edmund T Rolls, W Patrick C Mills
A fundamental question is how the cerebral neocortex operates functionally, computationally. The cerebral neocortex with its superficial and deep layers and highly developed recurrent collateral systems that provide a basis for memory-related processing might perform somewhat different computations in the superficial and deep layers. Here we take into account the quantitative connectivity within and between laminae. Using integrate-and-fire neuronal network simulations that incorporate this connectivity, we first show that attractor networks implemented in the deep layers that are activated by the superficial layers could be partly independent in that the deep layers might have a different time course, which might because of adaptation be more transient and useful for outputs from the neocortex...
October 16, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28985553/lncrnas-hif1a-as2-facilitates-the-up-regulation-of-hif-1%C3%AE-by-sponging-to-mir-153-3p-whereby-promoting-angiogenesis-in-huvecs-in-hypoxia
#20
Lingjuan Li, Mingyue Wang, Zhujun Mei, Wenfeng Cao, Yun Yang, Yanmei Wang, An Wen
Angiogenesis serves as an important protective mechanism against ischemic stroke, because angiogenesis promotes the generation of collateral circulation and consequently improves the blood supply to cerebral infraction areas. Long noncoding RNAs (lncRNAs), which can act as a competing endogenous RNA, mediate protein-coding gene expression by sponging miRNA. Based on previous studies, the present study hypothesized that lncRNAs HIF1A-AS2 by sponging to miR-153-3p might regulate expression of HIF-1α and its down-stream targets, thereby influencing angiogenesis in hypoxia...
October 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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