keyword
MENU ▼
Read by QxMD icon Read
search

Staging

keyword
https://www.readbyqxmd.com/read/28750496/tau-imaging-with-pet-an-overview-of-challenges-current-progress-and-future-applications
#1
Joanne S Robertson, Christopher C Rowe, Victor L Villemagne
Folded and misfolded tau is common to many neurodegenerative conditions, collectively termed 'tauopathies'. In recent years, many efforts have contributed toward development of tau imaging agents to allow measurement of tau deposits in vivo using Positron Emission Tomography (PET). The particularities of tau present some unique challenges for the development of tau imaging tracers. Most notably, these pertain to the predominantly intracellular nature of tau aggregations, the existence of six isoforms, multiple post-translational modification, and that tau is usually surrounded by larger concentrations of A plaques...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28750493/concomitant-semi-quantitative-and-visual-analysis-improves-the-predictive-value-on-treatment-outcome-of-interim-18f-fluorodeoxyglucose-positron-emission-tomography-in-advanced-hodgkin-lymphoma
#2
Alberto Biggi, Fabrizio Bergesio, Stephane Chauvie, Andrea Bianchi, Massimo Menga, Federico Fallanca, Martin Hutchings, Michele Gregianin, Michel Meignan, Andrea Gallamini
BACKGROUND: Qualitative assessment using the Deauville five-point scale (DS) is the gold standard for interim and end-of treatment PET interpretation in lymphoma. In the present study we assessed the reliability and the prognostic value of different semi- quantitative (SQ) parameters in comparison with DS for interim PET (iPET) interpretation in Hodgkin lymphoma (HL). METHODS: A cohort of 82 out of 260 patients with advanced stage HL enrolled in the International Validation Study (IVS), scored as 3 to 5 by the expert panel was included in the present report...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28750482/infrared-ion-spectroscopy-inside-a-mass-selective-cryogenic-2d-linear-ion-trap
#3
Adam P Cismesia, Larry F Tesler, Matthew R Bell, Laura S Bailey, Nicolas C Polfer
We demonstrate operation of the first cryogenic 2D linear ion trap (LIT) with mass-selective capabilities. This trap presents a number of advantages for infrared ion "action" spectroscopy studies, particularly those employing the "tagging/messenger" spectroscopy approach. The high trapping efficiencies, trapping capacities, and low detection limits make 2D LITs a highly suitable choice for low-concentration analytes from scarce biological samples. In our trap, ions can be cooled down to cryogenic temperatures to achieve higher-resolution infrared spectra, and individual ions can be mass selected prior to irradiation for a background-free photodissociation scheme...
July 27, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28750448/-role-of-the-human-erbb-family-receptors-in-urothelial-carcinoma-of-the-bladder-mrna-expression-status-and-prognostic-relevance
#4
Philipp Erben, Felix Wezel, Ralph Wirtz, Thomas Martini, Doron Stein, Cleo-Aaron Weis, Arndt Hartmann, Christian Bolenz
Background Altered expression of epidermal growth factor (EGF) family (ErbB) receptors in urothelial carcinoma of the urinary bladder (UCB) has been associated with adverse outcomes. Given the limited treatment options in UCB, EGFR and HER2 (ERBB2) represent established therapeutic targets in other entities. We assessed the expression of ErbB family receptors (ERBB1 - 4) on mRNA levels in correlation with histopathological and clinical parameters in patients treated with radical cystectomy (RC). Methods 94 patients (female = 22; male = 72; median age: 66...
August 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28750447/-en-bloc-resection-of-bladder-tumours-erbt-current-and-future-perspectives
#5
J P Struck, M W Kramer, A S Merseburger, A Hartmann, T R W Herrmann
Limitations inherent in the conventional transurethral resection of bladder tumours, the standard approach for diagnosis and treatment of bladder cancer, are well known: staging errors due to insufficient resection depth as well as intravesical tumour fragmentation, both of which make histopathological evaluation difficult. The purpose of this review is to present recent clinical data on the en-bloc resection of bladder tumours (ERBT), which has been demonstrated to offer a high potential to overcome these limitations...
August 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28750408/silencing-of-prrx2-inhibits-the-invasion-and-metastasis-of-breast-cancer-both-in-vitro-and-in-vivo-by-reversing-epithelial-mesenchymal-transition
#6
Zhi-Dong Lv, Hai-Bo Wang, Xiang-Ping Liu, Li-Ying Jin, Ruo-Wu Shen, Xin-Gang Wang, Bin Kong, Hui-Li Qu, Fu-Nian Li, Qi-Feng Yang
BACKGROUND/AIMS: Epithelial-mesenchymal transition (EMT) is recognized as a crucial mechanism in breast cancer progression and metastasis. Paired-related homeobox 2 (Prrx2) has been identified as a new EMT inducer in cancer, but the underlying mechanisms are still poorly understood. METHODS: The expression of Prrx2 was assessed by immunohistochemistry in breast cancer tissues to evaluate the clinicopathological significance of Prrx2, as well as the correlation between Prrx2 and EMT...
July 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28750367/challenges-associated-with-managing-end-stage-renal-disease-in-extremely-morbid-obese-patients-case-series-and-literature-review
#7
Faruk Turgut, Emaad M Abdel-Rahman
Obesity has grown into an epidemic across the globe. Mirroring this growth in the number of obese individuals in the general population, the prevalence of obesity and extremely morbid obesity (body mass index >50 kg/m2) is similarly rising in patients with end-stage renal disease (ESRD). Obesity, and more so, extremely morbid obesity, creates additional challenges for clinicians aiming at providing the best treatment options to patients with ESRD. Although literature is available regarding renal replacement therapy (RRT) for obese patients, literature about challenges facing clinicians managing ESRD in the extremely obese patients is lacking...
July 28, 2017: Nephron
https://www.readbyqxmd.com/read/28750363/to-predict-the-radiosensitivity-of-nasopharyngeal-carcinoma-using-intravoxel-incoherent-motion-mri-at-3-0-t
#8
Wen Bo Chen, Bin Zhang, Long Liang, Yu Hao Dong, Guan Hui Cai, Chang Hong Liang, Bo Wen Lan, Shui Xing Zhang
PURPOSE: To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC). RESULTS: The reproducibility between intra-observer and inter-observer was relatively good. D (0.72×10-3 mm2/s±0.14 vs. 0.54×10-3 mm2/s±0.23; P < 0.001) and D* (157.92×10-3 mm2/s±15.21 vs. 120.36×10-3 mm2/s±10.22; P < 0.0001) were significantly higher in effective group than poor-effective group, whereas the difference of f (18...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28750338/mos2-la-pei-nanocomposite-carrier-for-real-time-imaging-of-atp-metabolism-in-glioma-stem-cells-co-cultured-with-endothelial-cells-on-a-microfluidic-system
#9
Nan Li, Weifei Zhang, Mashooq Khan, Ling Lin, Jin-Ming Lin
Stimuli-responsive carriers have extensively attracted attention in recent years. However, long-term and real-time tracking ability with stimuli-responsive carrier is still in its infant stage due to the limitations such as, low efficacy, instability and cytotoxicity in a bio-environment. In this work, we developed a reduction-sensitive carrier composed of lipoic acid-modified low molecular weight polyethyleneimine (LA-PEI) and large surface ratio MoS2 nanosheet integrated via disulfide bond to mimic a high molecular weight PEI...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28750336/recent-advances-in-biosensor-technology-in-assessment-of-early-diabetes-biomarkers
#10
REVIEW
Armin Salek-Maghsoudi, Faezeh Vakhshiteh, Raheleh Torabi, Shokoufeh Hassani, Mohammad Reza Ganjali, Parviz Norouzi, Morteza Hosseini, Mohammad Abdollahi
Discovery of biosensors has acquired utmost importance in the field of healthcare. Recent advances in biological techniques and instrumentation involving nanomaterials, surface plasmon resonance, and aptasensors have developed innovative biosensors over classical methods. Integrated approaches provided a better perspective for developing specific and sensitive devices with wide potential applications. Type 2 diabetes mellitus is a complex disease affecting almost every tissue and organ system, with metabolic complications extending far beyond impaired glucose metabolism...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28750312/synthesis-of-2-imino-and-2-hydrazono-thiazolo-4-5-d-pyrimidines-as-corticotropin-releasing-factor-crf-antagonists
#11
Mohamed Teleb, Bhimanna Kuppast, Katerina Spyridaki, George Liapakis, Hesham Fahmy
Corticotropin-releasing factor (CRF) is an important neuropeptide hormone which controls the body's overall response to stress. It plays a crucial role in regulating the behavioral, cardiovascular, immune and gastrointestinal systems. Over-activation of the CRF system has been implicated in many disorders including anxiety, depression, drug addiction, hypertension, Irritable Bowel Syndrome (IBS), peptic ulcers, inflammation and others. Thus, binding of CRF to its receptors is an attractive target to develop new medications which aim at treating ailments associated with chronic stress...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28750303/initial-investigations-of-spectral-measurements-to-estimate-the-time-within-stages-of-protophormia-terraenovae-robineau-desvoidy-diptera-calliphoridae
#12
Jodie-A Warren, T D Pulindu Ratnasekera, David A Campbell, Gail S Anderson
Current applications of forensic entomology to post-mortem interval estimations involve ageing the insects colonizing the remains based on minimum time to reach the oldest stage of development. Immature species of blow fly develop at a predictable rate to each stage of development in their lifecycle. Unfortunately, the minimum time to reach a stage of development can be a rather unrefined estimate of tenure on the body in the sometimes lengthy time frame of the later stages. In a successful attempt to narrow this time frame, daily spectral measurements of the immature stages of Protophormia terraenovae (Robineau-Desvoidy) raised at a mean temperature of 24...
July 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28750293/effects-of-polystyrene-microbeads-in-marine-planktonic-crustaceans
#13
Chiara Gambardella, Silvia Morgana, Sara Ferrando, Mattia Bramini, Veronica Piazza, Elisa Costa, Francesca Garaventa, Marco Faimali
Plastic debris accumulates in the marine environment, fragmenting into microplastics (MP), causing concern about their potential toxic effects when ingested by marine organisms. The aim of this study was to verify whether 0.1µm polystyrene beads are likely to trigger lethal and sub-lethal responses in marine planktonic crustaceans. MP build-up, mortality, swimming speed alteration and enzyme activity (cholinesterases, catalase) were investigated in the larval stages of Amphibalanus amphitrite barnacle and of Artemia franciscana brine shrimp exposed to a wide range of MP concentrations (from 0...
July 24, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28750250/philosophical-and-theoretical-content-of-the-nursing-discipline-in-academic-education-a-critical-interpretive-synthesis
#14
REVIEW
Maria Luisa Rega, Fabia Telaretti, Rosaria Alvaro, Mari Kangasniemi
BACKGROUND: Nursing as clinical practice, management and research are based on nursing philosophy and theory. Thus, the philosophical and theoretical content is required to be incorporated in academic education in order to enable nurses' skills for reflection, analysis, and thinking about the profession. OBJECTIVE: The aim of this review was to describe what is known of the philosophical and theoretical content of the nursing discipline within academic education...
July 13, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28750228/radionuclides-and-soil-properties-as-indicators-of-glacier-retreat-in-a-recently-deglaciated-permafrost-environment-of-the-maritime-antarctica
#15
Ana Navas, Marc Oliva, Jesús Ruiz-Fernández, Leticia Gaspar, Laura Quijano, Iván Lizaga
Many ice-free environments in Maritime Antarctica are undergoing rapid and substantial environmental changes in response to recent climate trends. This is the case of Elephant Point (Livingston Island, South Shetland Islands, SSI), where the glacier retreat recorded during the last six decades exposed 17% of this small peninsula, namely a moraine extending from the western to the eastern coastlines and a relatively flat proglacial surface. In the southern margin of the peninsula, a sequence of Holocene raised beaches and several bedrock plateaus are also distributed...
July 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28750141/hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-c-and-cirrhosis-in-denmark-a-nationwide-cohort-study
#16
Sofie Hallager, Steen Ladelund, Mette S Kjaer, Lone G Madsen, Erika Belard, Alex Lund Laursen, Jan Gerstoft, Birgit T Røge, Karin E Grønbaek, Henrik B Krarup, Peer B Christensen, Nina Weis
Cirrhosis in patients with chronic hepatitis C increases the risk of hepatocellular carcinoma (HCC) and surveillance with ultrasound (US) and alpha-fetoprotein (AFP) is recommended. This study aimed to estimate changes in the HCC incidence rate (IR) over time, HCC stage and prognosis, and AFP and US performed in patients with hepatitis C and cirrhosis. Eligible patients were identified in the Danish Database for Hepatitis B and C and data from national health registries and patient charts were obtained. Tumor stage was based on Barcelona-Clinic Liver Cancer stage, TNM classification and size and number of lesions combined into stage 0 - 3...
July 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28750139/is-mitotic-rate-still-useful-in-the-management-of-patients-with-thin-melanoma
#17
Antonio Tejera-Vaquerizo, Gladys Pérez-Cabello, Lorena Marínez-Leborans, Elena Gallego, Vicente Oliver-Martínez, Paula Martín-Cuevas, Salvador Arias-Santiago, José Aneiros-González, Enrique Herrera-Acosta, Victor Traves, Enrique Herrera-Ceballos, Eduardo Nagore
BACKGROUND: T1 melanoma substaging was recently modified by the American Joint Committee on Cancer (AJCC). Although sentinel lymph node (SLN) positivity is the most important prognostic factor in melanoma, there is a lack of consensus on whether SLN biopsy should be performed in patients with thin melanoma (≤1 mm). OBJECTIVE: The main aim of this study was to investigate predictors of SLN positivity in patients with thin melanoma, with a special emphasis on mitotic rate...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28750136/changes-in-margin-re-excision-rates-experience-incorporating-the-no-ink-on-tumor-guideline-into-practice
#18
Caitlin R Patten, Kendall Walsh, Terry Sarantou, Lejla Hadzikadic-Gusic, Meghan R Forster, Myra Robinson, Richard L White
INTRODUCTION: Prior to the "no ink on tumor" SSO/ASTRO consensus guideline, approximately 20% of women with stage I/II breast cancers undergoing breast conservation surgery at our institution underwent margin re-excision. On May 20, 2013, our institution changed the definition of negative margins from 2 mm to "no ink on tumor." METHODS: A retrospective review was conducted of patients who had surgery at our institution with clinical stage I/II breast cancers between June 1, 2011 and May 1, 2015...
July 27, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28750113/handheld-optical-coherence-tomography-angiography-and-ultra-wide-field-optical-coherence-tomography-in-retinopathy-of-prematurity
#19
J Peter Campbell, Eric Nudleman, Jianlong Yang, Ou Tan, R V Paul Chan, Michael F Chiang, David Huang, Gangjun Liu
Importance: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultra-wide-field OCT or OCTA images in neonates. Objective: To obtain ultra-wide-field OCT and OCTA images in neonates with ROP using a prototype handheld OCT and OCTA device...
July 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28750095/serum-tumor-associated-autoantibodies-as-diagnostic-biomarkers-for-lung-cancer-a-systematic-review-and-meta-analysis
#20
Zhen-Ming Tang, Zhou-Gui Ling, Chun-Mei Wang, Yan-Bin Wu, Jin-Liang Kong
OBJECTIVE: We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC). METHODS: We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test. RESULTS: The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies...
2017: PloS One
keyword
keyword
27026
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"