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https://www.readbyqxmd.com/read/28437993/integrated-optical-force-sensors-using-focusing-photonic-crystal-arrays
#1
Jingkun Guo, Richard A Norte, S Gröblacher
Mechanical oscillators are at the heart of many sensor applications. Recently several groups have developed oscillators that are probed optically, fabricated from high-stress silicon nitride films. They exhibit outstanding force sensitivities of a few aN/Hz<sup>1/2</sup> and can also be made highly reflective, for efficient detection. The optical read-out usually requires complex experimental setups, including positioning stages and bulky cavities, making them impractical for real applications. In this paper we propose a novel way of building fully integrated all-optical force sensors based on low-loss silicon nitride mechanical resonators with a photonic crystal reflector...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437896/variability-of-apparent-and-inherent-optical-properties-of-sediment-laden-waters-in-large-river-basins-lessons-from-in-situ-measurements-and-bio-optical-modeling
#2
Sylvain Pinet, Jean-Michel Martinez, Sylvain Ouillon, Bruno Lartiges, Raul Espinoza Villar
We investigated the relationships between inherent and apparent optical properties (IOP and AOP, respectively) and suspended sediment concentrations (SSC) in the main Amazonian river waters. In situ measurements of SSC, remote sensing reflectance (R<sub>rs</sub>), the diffuse light attenuation coefficient (K<sub>d</sub>) and the total and non-algal particle (NAP) absorption coefficients (a<sub>TOT</sub> and a<sub>NAP</sub>, respectively) were conducted during three sampling trips along different streams of the Amazon River catchment (104 stations)...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437861/three-stage-decision-making-model-under-restricted-conditions-for-emergency-response-to-ships-not-under-control
#3
Bing Wu, Xinping Yan, Yang Wang, Di Zhang, C Guedes Soares
A ship that is not under control (NUC) is a typical incident that poses serious problems when in confined waters close to shore. The emergency response to NUC ships is to select the best risk control options, which is a challenge in restricted conditions (e.g., time limitation, resource constraint, and information asymmetry), particularly in inland waterway transportation. To enable a quick and effective response, this article develops a three-stage decision-making framework for NUC ship handling. The core of this method is (1) to propose feasible options for each involved entity (e...
April 24, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28437839/semicarbazide-sensitive-amine-oxidase-vascular-adhesion-protein-1-inhibition-reduces-lipopolysaccharide-induced-neuroinflammation
#4
Serena Becchi, Alberto Buson, Jonathan Foot, Wolfgang Jarolimek, Bernard W Balleine
BACKGROUND AND PURPOSE: Neuroinflammation is initiated by a variety of stimuli including infections, sepsis, neurodegenerative diseases or traumatic brain injury and if not adequately controlled can lead to various degrees of neuronal damage and behavioural impairment. A critical event in the initial steps of inflammation is neutrophil extravasation. Semicarbazide sensitive amine oxidase (SSAO, also known as vascular adhesion protein 1 or VAP-1) regulates neutrophil adhesion and extravasation...
April 24, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28437790/utility-in-treating-kidney-failure-in-end-stage-liver-disease-with-simultaneous-liver-kidney-transplantation
#5
Xingxing S Cheng, Margaret R Stedman, Glenn M Chertow, W Ray Kim, Jane C Tan
BACKGROUND: Simultaneous liver-kidney (SLK) transplantation plays an important role in treating kidney failure in patients with end-stage liver disease. It used 5% of deceased donor kidney transplanted in 2015. We evaluated the utility, defined as posttransplant kidney allograft lifespan, of this practice. METHODS: Using data from the Scientific Registry of Transplant Recipients, we compared outcomes for all SLK transplants between January 1, 1995, and December 3, 2014, to their donor-matched kidney used in kidney-alone (Ki) or simultaneous pancreas kidney (SPK) transplants...
May 2017: Transplantation
https://www.readbyqxmd.com/read/28437766/cyanobacterial-lectins-characteristics-and-their-role-as-antiviral-agents
#6
REVIEW
Ram Sarup Singh, Amandeep Kaur Walia, Jasvirinder Singh Khattar, Davinder Pal Singh, John F Kennedy
Lectins are ubiquitous proteins/glycoproteins of non-immune origin that bind reversibly to carbohydrates in non-covalent and highly specific manner. These lectin-glycan interactions could be exploited for establishment of novel therapeutics, targeting the adherence stage of viruses and thus helpful in eliminating wide spread viral infections. Here the review focuses on the haemagglutination activity, carbohydrate specificity and characteristics of cyanobacterial lectins. Cyanobacterial lectins exhibiting high specificity towards mannose or complex glycans have potential role as anti-viral agents...
April 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28437750/becoming-comfortable-with-my-epilepsy-strategies-that-patients-use-in-the-journey-from-diagnosis-to-acceptance-and-disclosure
#7
Sinead Pembroke, Agnes Higgins, Niall Pender, Naomi Elliott
OBJECTIVE: Proponents of resilience theory have highlighted the importance of understanding the processes of resilience. The objective of the study was to explore how people with epilepsy reach a stage of being comfortable with their epilepsy. Identifying the processes used is important to developing effective self-management for people who are newly diagnosed with epilepsy. METHOD: A grounded theory approach involving forty-nine consenting adult people with epilepsy (18 years and over), was used to explore their first-hand experiences of coming to terms with their epilepsy...
April 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28437737/changes-in-regulatory-t-cells-in-patients-with-ovarian-cancer-undergoing-surgery-preliminary-results
#8
Meng Wu, Xian Chen, Jianfang Lou, Shuping Zhang, Xiaojie Zhang, Lei Huang, Ruihong Sun, Peijun Huang, Shiyang Pan, Fang Wang
Regulatory T cells (Treg) suppress immune responses in patients with cancer. Surgery is the most effective therapeutic strategy for ovarian cancer (OC). However, the interplay between the Treg population and surgical resection remains unclear. 61 patients with OC who received no prior treatment were enrolled in the study. Treg percentages were characterized from peripheral blood mononuclear cells. We investigated CD4(+)CD25(+), CD4(+)CD25(+)Foxp3(+), CD8(+)CD28(-), and CD8(+)Foxp3(+) Tregs in OC patients and their postoperative changes using flow cytometry...
April 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28437692/stage-iv-colorectal-cancer-primary-site-and-patterns-of-distant-metastasis
#9
Jamaica R Robinson, Polly A Newcomb, Sheetal Hardikar, Stacey A Cohen, Amanda I Phipps
BACKGROUND: Although colorectal cancer (CRC) usually metastasizes to the liver and/or lungs, factors influencing the anatomic pattern of metastases remain poorly understood. METHODS: We assessed the relationship between primary CRC site and pattern of synchronous metastasis among 1202 individuals diagnosed with incident metastatic CRC between 2010 and 2014 and identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) registry...
April 21, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28437679/nodal-recurrence-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-incidence-and-proposed-risk-factors
#10
REVIEW
Krista C J Wink, Angela van Baardwijk, Esther G C Troost, Dirk De Ruysscher
Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with endobronchial ultrasound and/or mediastinoscopy, and typically undergo intra-operative lymph node dissection or sampling...
April 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28437655/peripheral-artery-disease-redox-signaling-oxidative-stress-basic-and-clinical-aspects
#11
REVIEW
Sebastian Steven, Andreas Daiber, Jörn F Dopheide, Thomas Münzel, Christine Espinola-Klein
Reactive oxygen and nitrogen species (ROS and RNS, e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. At higher concentrations, ROS and RNS lead to oxidative stress and oxidative damage of biomolecules (e.g. via formation of peroxynitrite, fenton chemistry). Peripheral artery disease (PAD) is characterized by severe ischemic conditions in the periphery leading to intermittent claudication and critical limb ischemia (end stage)...
April 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28437628/advanced-biomaterials-and-microengineering-technologies-to-recapitulate-the-stepwise-process-of-cancer-metastasis
#12
REVIEW
Nitish Peela, Danh Truong, Harpinder Saini, Hunghao Chu, Samaneh Mashaghi, Stephanie L Ham, Sunil Singh, Hossein Tavana, Bobak Mosadegh, Mehdi Nikkhah
Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies...
April 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/28437608/crispr-cas9-mediated-dna-unwinding-detected-using-site-directed-spin-labeling
#13
Narin S Tangprasertchai, Rosa Di Felice, Xiaojun Zhang, Ian M Slaymaker, Carolina Vazquez Reyes, Wei Jiang, Remo Rohs, Peter Z Qin
The RNA-guided CRISPR-Cas9 nuclease has revolutionized genome engineering, yet its mechanism for DNA target selection is not fully understood. A crucial step in Cas9 target recognition involves unwinding of the DNA duplex to form a three-stranded R-loop structure. Work reported here demonstrates direct detection of Cas9-mediated DNA unwinding by a combination of site-directed spin labeling and Molecular Dynamics simulations. The results support a model in which the unwound non-target strand is stabilized by a positively-charged patch located between the two nuclease domains of Cas9, and reveal uneven increases in flexibility along the unwound non-target strand upon scissions of the DNA backbone...
April 24, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28437604/antiplasmodial-mode-of-action-of-pantothenamides-pantothenate-kinase-serves-as-a-metabolic-activator-not-as-a-target
#14
Marianne de Villiers, Christina Spry, Cristiano Joao Macuamule, Leanne Barnard, Gordon Wells, Kevin J Saliba, Erick Strauss
N-substituted pantothenamides (PanAms) are pantothenate analogues with up to nanomolar potency against blood-stage Plasmodium falciparum (the most virulent species responsible for malaria). Although these compounds are known to target coenzyme A (CoA) biosynthesis and/or utilization, their exact mode of action (MoA) is still unknown. Importantly, PanAms that retain the natural β-alanine moiety are more potent than other variants, consistent with the involvement of processes that are selective for pantothenate (the precursor of CoA) or its derivatives...
April 24, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28437580/differential-gene-expression-in-narrow-and-broad-headed-european-glass-eels-anguilla-anguilla-points-to-a-transcriptomic-link-of-head-shape-dimorphism-with-growth-rate-and-chemotaxis
#15
J De Meyer, G E Maes, R P Dirks, D Adriaens
One of the major challenges in evolutionary biology is to understand the mechanisms underlying morphological dimorphism and plasticity, including the genomic basis of traits and links to ecology. At the yellow eel stage of the European eel (Anguilla anguilla), two morphotypes are found: broad- and narrow-heads. This dimorphism has been linked to dietary differences, with broad-heads feeding on harder, larger prey than narrow-heads. However, recent research showed that both morphotypes could be distinguished at the glass eel stage, the non-feeding predecessor of the yellow eel stage, implying that non-dietary factors play a role in the development of this head shape dimorphism...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28437557/expression-of-catalase-alcohol-dehydrogenase-and-malate-dehydrogenase-in-rot-grains-upon-fungicide-use-on-maize-hybrids-grown-at-different-spacings
#16
E R Kluge, M C Mendes, M V Faria, H O Santos, L A Santos, I E Sandini
In this study, we evaluated the fungicide effect on the incidence of rot grains and expression of catalase (CAT), alcohol dehydrogenase (ADH), and malate dehydrogenase (MDH) enzymes in commercial maize hybrids grown with conventional and reduced spacing in Guarapuava, PR, Brazil. The experiment was designed in random blocks with a 3 × 8-factorial scheme, totaling 24 treatments. The first factor constituted three levels, the first with foliar fungicide application [150.0 g/L trifloxystrobin (15.0%, w/v) + 175...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28437528/automated-staging-of-age-related-macular-degeneration-using-optical-coherence-tomography
#17
Freerk G Venhuizen, Bram van Ginneken, Freekje van Asten, Mark J J P van Grinsven, Sascha Fauser, Carel B Hoyng, Thomas Theelen, Clara I Sánchez
Purpose: To evaluate a machine learning algorithm that automatically grades age-related macular degeneration (AMD) severity stages from optical coherence tomography (OCT) scans. Methods: A total of 3265 OCT scans from 1016 patients with either no signs of AMD or with signs of early, intermediate, or advanced AMD were randomly selected from a large European multicenter database. A machine learning system was developed to automatically grade unseen OCT scans into different AMD severity stages without requiring retinal layer segmentation...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28437502/combined-anterior-posterior-decompression-and-fusion-for-cervical-spondylotic-myelopathy
#18
Richard Bram, Susan Fiore, John J Labiak, Raphael P Davis
We conducted a study to evaluate the operative details, perioperative complications, and short-term outcomes associated with combined anterior-posterior decompression and fusion (CAPDF) for treating cervical spondylotic myelopathy (CSM). We retrospectively reviewed the charts of 21 patients who underwent CAPDF at our institution. Pertinent information, including demographics, surgery indication, perioperative complications, operative time, levels fused (and number of levels fused) anteriorly and posteriorly, estimated blood loss, and length of stay, was gathered...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28437487/crop-and-varietal-diversification-of-rainfed-rice-based-cropping-systems-for-higher-productivity-and-profitability-in-eastern-india
#19
B Lal, Priyanka Gautam, B B Panda, R Raja, Teekam Singh, R Tripathi, M Shahid, A K Nayak
Rice-rice system and rice fallows are no longer productive in Southeast Asia. Crop and varietal diversification of the rice based cropping systems may improve the productivity and profitability of the systems. Diversification is also a viable option to mitigate the risk of climate change. In Eastern India, farmers cultivate rice during rainy season (June-September) and land leftovers fallow after rice harvest in the post-rainy season (November-May) due to lack of sufficient rainfall or irrigation amenities...
2017: PloS One
https://www.readbyqxmd.com/read/28437466/stage-call-cardiovascular-reactivity-to-audition-stress-in-musicians
#20
Theerasak Chanwimalueang, Lisa Aufegger, Tricia Adjei, David Wasley, Cinzia Cruder, Danilo P Mandic, Aaron Williamon
Auditioning is at the very center of educational and professional life in music and is associated with significant psychophysical demands. Knowledge of how these demands affect cardiovascular responses to psychosocial pressure is essential for developing strategies to both manage stress and understand optimal performance states. To this end, we recorded the electrocardiograms (ECGs) of 16 musicians (11 violinists and 5 flutists) before and during performances in both low- and high-stress conditions: with no audience and in front of an audition panel, respectively...
2017: PloS One
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