Harrison T Shanley, Aya C Taki, Nghi Nguyen, Tao Wang, Joseph J Byrne, Ching-Seng Ang, Michael G Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D Young, Pasi K Korhonen, Andreas Hofmann, Bill C H Chang, Tim N C Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E Sleebs, Robin B Gasser
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against the free-living nematode Caenorhabditis elegans; and predicted compound-target relationships by thermal proteome profiling (TPP) and in silico docking. Here, we logically extended this work and critically evaluated the anthelmintic activity of ABX464 analogues on Haemonchus contortus (barber's pole worm) - a highly pathogenic nematode of ruminant livestock...
January 23, 2024: International Journal for Parasitology, Drugs and Drug Resistance