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https://www.readbyqxmd.com/read/29661454/successful-treatment-of-strongyloides-stercoralis-hyperinfection-in-a-kidney-transplant-recipient-case-report
#1
J Rego Silva, R A Macau, A Mateus, P Cruz, M J Aleixo, M Brito, A Alcobia, C Oliveira, A Ramos
Strongyloides stercoralis (SS) can cause hyperinfection and disseminated infection in immunosuppressed individuals, with risk of mortality. We report the case of a cadaveric kidney transplant recipient who developed gastrointestinal symptoms and eosinophilia, approximately 3 months after transplantation. Stool examination and esophagogastroduodenoscopy with biopsies were positive for SS larvae. The patient was started on oral ivermectin and immunosuppression was reduced, but still the clinical picture got worse with metabolic ileus and respiratory symptoms, with the need for administration of subcutaneous ivermectin and combined therapy with albendazol...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29653264/helminth-infection-in-mice-improves-insulin-sensitivity-via-modulation-of-gut-microbiota-and-fatty-acid-metabolism
#2
Fernanda Pace, Bruno M Carvalho, Tamires M Zanotto, Andrey Santos, Dioze Guadagnini, Kelly L C Silva, Maria Carolina S Mendes, Guilherme Z Rocha, Silmara M Alegretti, Gustavo A Santos, Rodrigo R Catharino, Rita Paroni, Franco Folli, Mário José A Saad
Intestinal helminths are prevalent in individuals who live in rural areas of developing countries, where obesity, type 2 diabetes, and metabolic syndrome are rare. In the present study, we analyzed the modulation of the gut microbiota in mice infected with the helminth Strongyloides venezuelensis, and fed either a standard rodent chow diet or high-fat diet (HFD). To investigate the effects of the microbiota modulation on the metabolism, we analyzed the expression of tight-junction proteins present in the gut epithelium, inflammatory markers in the serum and tissue and quantified glucose tolerance and insulin sensitivity and resistance...
April 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29590236/evaluation-of-the-recombinant-antigens-wb14-and-wbt-for-the-capture-antibody-diagnosis-of-lymphatic-filariasis
#3
André Filipe Pastor, Abraham Rocha, Klécia de Melo Cassemiro, Marli Tenório, Paula Melo, Maria Rosângela Grilis, Maressa Rhuama, Antonio Mauro Rezende, Osvaldo Pompilio de Melo Neto, Ernesto Marques, Rafael Dhalia
BACKGROUND: Lymphatic filariasis (LF) is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis) and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity) and limited diagnostic kits. OBJECTIVES: The aim of this work was to evaluate two recombinant antigens (Wb14 and WbT) as part of an enzyme-linked immunosorbent assay (ELISA) based antibody capture tests for LF...
March 26, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29582037/blood-screen-findings-in-a-2-year-cohort-of-newly-arrived-refugees-to-sydney-australia
#4
Choisung C Ngo, Christine Maidment, Lisa Atkins, Sandy Eagar, Mitchell M Smith
OBJECTIVES: To describe the prevalence of certain health conditions in newly arrived refugees to Sydney, Australia, and thereby help inform screening practices. STUDY TYPE: A clinical audit of routinely collected pathology results. METHODS: Demographics and pathology results from a nurse-led health assessment program for newly arrived refugees during 2013 and 2014 were analysed. Prevalences of screened conditions were calculated, and compared by country of birth and other demographic features...
March 15, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29581469/comparative-transcriptomics-gives-insights-into-the-evolution-of-parasitism-in-strongyloides-nematodes-at-the-genus-subclade-and-species-level
#5
Vicky L Hunt, Akina Hino, Akemi Yoshida, Taisei Kikuchi
Strongyloides spp., gastrointestinal nematode parasites of humans and other animals, have genetically identical parasitic and free-living adult life cycle stages. This is an almost unique feature amongst nematodes and comparison of these two stages can provide insights into the genetic basis and evolution of Strongyloides nematode parasitism. Here, we present RNAseq data for S. venezuelensis, a parasite of rodents, and identify genes that are differentially expressed in parasitic and free-living life cycle stages...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29580279/distinct-clinical-characteristics-and-helminth-co-infections-in-adult-tuberculosis-patients-from-urban-compared-to-rural-tanzania
#6
George Sikalengo, Jerry Hella, Francis Mhimbira, Liliana K Rutaihwa, Farida Bani, Robert Ndege, Mohamed Sasamalo, Lujeko Kamwela, Khadija Said, Grace Mhalu, Yeromin Mlacha, Christoph Hatz, Stefanie Knopp, Sébastien Gagneux, Klaus Reither, Jürg Utzinger, Marcel Tanner, Emilio Letang, Maja Weisser, Lukas Fenner
BACKGROUND: Differences in rural and urban settings could account for distinct characteristics in the epidemiology of tuberculosis (TB). We comparatively studied epidemiological features of TB and helminth co-infections in adult patients from rural and urban settings of Tanzania. METHODS: Adult patients (≥ 18 years) with microbiologically confirmed pulmonary TB were consecutively enrolled into two cohorts in Dar es Salaam, with ~ 4.4 million inhabitants (urban), and Ifakara in the sparsely populated Kilombero District with ~ 400 000 inhabitants (rural)...
March 24, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29579050/seroepidemiology-of-helminths-and-the-association-with-severe-malaria-among-infants-and-young-children-in-tanzania
#7
Jennifer L Kwan, Amy E Seitz, Michal Fried, Kun-Lin Lee, Simon Metenou, Robert Morrison, Edward Kabyemela, Thomas B Nutman, D Rebecca Prevots, Patrick E Duffy
The disease burden of Wuchereria bancrofti and Plasmodium falciparum malaria is high, particularly in Africa, and co-infection is common. However, the effects of filarial infection on the risk of severe malaria are unknown. We used the remaining serum samples from a large cohort study in Muheza, Tanzania to describe vector-borne filarial sero-reactivity among young children and to identify associations between exposure to filarial parasites and subsequent severe malaria infections. We identified positive filarial antibody responses (as well as positive antibody responses to Strongyloides stercoralis) among infants as young as six months...
March 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29567897/-strongyloides-stercoralis-hyperinfection-in-an-unconscious-diabetic-patient-with-dermatomyositis
#8
Meysam Sharifdini, Aniseh Hesari, Seif Ali Mahdavi, Akram Alipour, Eshrat Beigom Kia
A case of Strongyloides stercoralis hyperinfection in a patient with dermatomyositis and diabetes mellitus is herein reported. The case was a 60-year-old female admitted due to watery diarrhea and unconsciousness. She had a 10-year history of chronic immunosuppressive therapy including methotrexate and prednisolone for dermatomyositis. Stool parasitological examination revealed numerous rhabditiform larvae of threadworm "S. stercoralis." Larva in stool sample was characterized by sequencing of mitochondrial DNA...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29564068/molecular-diagnosis-of-strongyloidiasis-in-a-population-of-an-endemic-area-through-nested-pcr
#9
Meysam Sharifdini, Amir Keyhani, Mohammad Reza Eshraghian, Eshrat Beigom Kia
Aim: This study is aimed to diagnose and analyze strongyloidiasis in a population of an endemic area of Iran using nested-PCR, coupled with parasitological methods. Background: Screening of strongyloidiasis infected people using reliable diagnostic techniques are essential to decrease the mortality and morbidity associated with this infection. Molecular methods have been proved to be highly sensitive and specific for detection of Strongyloides stercoralis in stool samples...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29563723/loeffler-s-syndrome-secondary-to-hyperinfection-by-strongyloides-stercoralis-associated-with-methotrexate-in-a-patient-with-rheumatoid-arthritis
#10
Moayad Al Hadidi, Hamid Shaaban, Khalid Hani Jumean, Paloma Peralta
No abstract text is available yet for this article.
January 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29559358/strongyloides-stercoralis-infection-an-unusual-cause-of-small-bowel-obstruction
#11
Wenhao Li, Amit Chattree
No abstract text is available yet for this article.
March 17, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29559130/gastro-intestinal-parasite-infections-of-ankole-cattle-in-an-unhealthy-landscape-an-assessment-of-ecological-predictors
#12
Ping Sun, Torsten Wronski, Jean D Bariyanga, Ann Apio
The distribution of gastro-intestinal (GI) parasites across landscapes is closely related to the spatial distribution of hosts. In GI parasites with environmental life stages, the vitality of parasites is also affected by ecological and landscape-related components of the environment. This is particularly relevant for domestic livestock species that are often kept across habitats with varying degrees of degradation, exposing them to a wide range of environmentally robust parasite species. In our study, we examined the effect of environmental and anthropogenic factors on the prevalence and intensity of GI parasites across a free-ranging stock of Ankole cattle in the Mutara rangelands of northeastern Rwanda...
March 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29538510/opportunistic-and-non-opportunistic-intestinal-parasites-in-hiv-aids-patients-in-relation-to-their-clinical-and-epidemiological-status-in-a-specialized-medical-service-in-goi%C3%A3-s-brazil
#13
Natane Barbosa Barcelos, Lorena de Freitas E Silva, Regyane Ferreira Guimarães Dias, Hélio Ranes de Menezes Filho, Rosângela Maria Rodrigues
Patients infected with the Human Immunodeficiency Virus (HIV) often have opportunistic infections, among which strongyloidiasis and coccidiosis are the most common parasitic infections that aggravate their health status. This study examined the prevalence of intestinal parasites, particularly of Strongyloides stercoralis and intestinal coccidia in patients with the Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) who were treated at the Specialized Assistance Service (SAE) of Jataí, State of Goiás, Brazil, and analyzed its correlation with clinical, laboratory, and socio-epidemiological parameters...
March 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29529857/endoparasites-of-small-mammals-in-edo-state-nigeria-public-health-implications
#14
Clement Isaac, Benjamin Igho Igbinosa, John Asekhaen Ohiolei, Catherine Eki Osimen
Some small mammals occur as household pests and harbour a number of parasites that could be of public health importance. This study profiled the helminth and protozoan parasites in trapped small mammals within and around human dwelling places (houses) located across 4 major towns (Auchi, Benin, Ekpoma, and Uromi) and environs in Edo state, Nigeria. Six genera ( Apodemus sp., Crocidura sp., Mastomys natalensis , Mus musculus , Rattus sp., and Sorex sp.) were identified from 502 trapped small mammals. Overall, M...
February 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29529848/prevalence-of-intestinal-parasites-and-associated-risk-factors-for-infection-among-rural-communities-of-chachoengsao-province-thailand
#15
Pisit Suntaravitun, Amornrat Dokmaikaw
Intestinal parasitic infections remain a major public health problem in many parts of Thailand, particularly in rural areas. This study aimed to determine the prevalence of intestinal parasitic infections and associated risk factors among the people living in Huai Sai sub-district, Bang Khla district, Chachoengsao Province, central Thailand. A cross-sectional survey was carried out from June 2017 to August 2017 which included a total of 224 participants. Stool samples were examined using a simple direct smear and formalin ethyl acetate concentration technique...
February 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29522552/intestinal-parasite-infections-in-a-rural-community-of-rio-de-janeiro-brazil-prevalence-and-genetic-diversity-of-blastocystis-subtypes
#16
Carolina Valença Barbosa, Magali Muniz Barreto, Rosemary de Jesus Andrade, Fernando Sodré, Claudia Masini d'Avila-Levy, José Mauro Peralta, Ricardo Pereira Igreja, Heloisa Werneck de Macedo, Helena Lucia Carneiro Santos
BACKGROUND: Intestinal parasitic infections are considered a serious public health problem and widely distributed worldwide, mainly in urban and rural environments of tropical and subtropical countries. Globally, soil-transmitted helminths and protozoa are the most common intestinal parasites. Blastocystis sp. is a highly prevalent suspected pathogenic protozoan, and considered an unusual protist due to its significant genetic diversity and host plasticity. METHODOLOGY/MAIN FINDINGS: A total of 294 stool samples were collected from inhabitants of three rural valleys in Rio de Janeiro, Brazil...
2018: PloS One
https://www.readbyqxmd.com/read/29513106/frequency-of-enteroparasites-and-bacteria-in-the-leafy-vegetables-sold-in-brazilian-public-wholesale-markets
#17
Eleuza R Machado, Iriani R Maldonade, Roberta F R Riquette, Vinícios S Mendes, Rodrigo Gurgel-Gonçalves, Veronica C Ginani
The consumption of raw vegetables is related to health benefits. However, these foods might be source of foodborne diseases. The objective of the present study was to perform a microbiological and parasitological evaluation of the leafy vegetables commercially sold in five regions of Brazil at public wholesale markets. The 12 types of leafy vegetables (144 samples) were curly lettuce, looseleaf lettuce, red lettuce, chives, coriander, kale, basil, arugula, parsley, iceberg lettuce, chicory, and bean sprouts...
April 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29512242/organ-donor-screening-practices-for-strongyloides-stercoralis-infection-among-us-organ-procurement-organizations
#18
Francisca A Abanyie, Emily Valice, Kristin W Delli Carpini, Elizabeth B Gray, Isabel McAuliffe, Peter V Chin-Hong, Sukwan Handali, Susan P Montgomery, Shirish Huprikar
BACKGROUND: Targeted donor screening for strongyloidiasis performed at the time of organ procurement can prevent this life-threatening donor-derived infection. METHOD: The Association of Organ Procurement Organizations surveyed members to determine the number of U.S. organ procurement organizations (OPOs) performing donor screening for Strongyloides infection and their screening practices. RESULTS: All 58 OPOs responded to the survey. Only six (10%) currently screen donors for strongyloidiasis; most OPOs started 6-36 months before the survey, one started 6 years prior...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29496523/ultraestructural-study-of-effects-of-alkylphospholipid-analogs-against-nematodes
#19
Viviane Sant' Anna, Marcelle Railbolt, Aleksandra Oliveira-Menezes, Theodora Calogeropoulou, Jairo Pinheiro, Wanderley de Souza
Alkylphospholipid analogs were initially developed as anticancer agents and were later found to antiparasitic activity. Miltefosine is the prototype alkylphosphocholine and is the first oral treatment against visceral leishmaniasis. Here we investigated the effects of miltefosine and two ring-substituted alkylphosphocholine derivatives, TCAN26 and TC70, on the viability, morphology, and ultrastructure of the life stages of Caenorhabditis elegans and infective larvae of the parasite Strongyloides venezuelensis...
February 26, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29493782/treatment-of-disseminated-strongyloides-spp-infection-in-an-infant-sumatran-orangutan-pongo-abelii
#20
Laura M Kleinschmidt, Matthew E Kinney, Christopher S Hanley
Strongyloides nematodes have been reported in all species of great apes with orangutans ≤5 years old most susceptible to severe clinical disease. This brief communication describes the first published case of antemortem diagnosis and treatment of disseminated strongyloidiasis in a clinically affected 5-month-old Sumatran orangutan (Pongo abelii).
March 1, 2018: Journal of Medical Primatology
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