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Arsenic exposure

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https://www.readbyqxmd.com/read/28229933/nuclear-lamins-and-progerin-are-dispensable-for-antioxidant-nrf2-response-to-arsenic-and-cadmium
#1
Kazunori Hashimoto, Rima Majumdar, Yoshiaki Tsuji
Lamins are important constituents of the nuclear inner membrane and provide a platform for transcription factors and chromatin. Progerin, a C-terminal truncated lamin A mutant, causes premature aging termed Hutchinson-Gilford Progeria Syndrome (HGPS). Oxidative stress appears to be involved in the pathogenesis of HGPS, although the mechanistic role of progerin remains elusive. Here we examined whether nuclear lamins are important for a cellular antioxidant mechanism, and whether progerin compromises it. We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts...
February 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28229170/molecular-insight-of-arsenic-induced-carcinogenesis-and-its-prevention
#2
REVIEW
Paramita Mandal
Population of India and Bangladesh and many other parts of the world are badly exposed to arsenic through drinking water. Due to non-availability of safe drinking water, they are dependent on arsenic-contaminated water. Generally, poverty level is high in those areas with lack of proper nutrition. Arsenic is considered to be an environmental contaminant and widely distributed in the environment due to its natural existence and anthropogenic applications. Contamination of arsenic in both human and animal could occur through air, soil, and other sources...
February 22, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28225195/protective-effect-of-hydroxytyrosol-in-arsenic-induced-mitochondrial-dysfunction-in-rat-brain
#3
Manisha Soni, Chandra Prakash, Sfurti Sehwag, Vijay Kumar
The present study was planned to investigate the protective effect of hydroxytyrosol (HT) against arsenic (As)-induced mitochondrial dysfunction in rat brain. Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria. As-treated rats showed reduced mRNA expression of complex I (ND-1, ND-2), IV (COX-1, COX-4) subunits, and uncoupling protein-2 (UCP-2). In addition to this, As exposure downregulated the protein expression of MnSOD...
February 22, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28224177/joint-toxicity-of-arsenic-copper-and-glyphosate-on-behavior-reproduction-and-heat-shock-protein-response-in-caenorhabditis-elegans
#4
Yunbiao Wang, Anastasia N Ezemaduka, Zhuheng Li, Zhanyan Chen, Chuantao Song
The soil nematode Caenorhabditis elegans was used in 24-h acute exposures to arsenic (As), copper (Cu) and glyphosate (GPS) and to mixtures of As/Cu and As/GPS to investigate the effects of mixture exposures in the worms. A synergistic type of interaction was observed for acute toxicity with the As/Cu and As/GPS mixtures. Sublethal 24-h exposures of 1/1000, 1/100 and 1/10 of the LC50 concentrations for As, Cu and GPS individually and for As/Cu and As/GPS mixtures were conducted to observe responses in locomotory behavior (head thrashing), reproduction, and heat shock protein expression...
February 21, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28223993/diacylglycerol-kinases-are-widespread-in-higher-plants-and-display-inducible-gene-expression-in-response-to-beneficial-elements-metal-and-metalloid-ions
#5
Hugo F Escobar-Sepúlveda, Libia I Trejo-Téllez, Paulino Pérez-Rodríguez, Juan V Hidalgo-Contreras, Fernando C Gómez-Merino
Diacylglycerol kinases (DGKs) are pivotal signaling enzymes that phosphorylate diacylglycerol (DAG) to yield phosphatidic acid (PA). The biosynthesis of PA from phospholipase D (PLD) and the coupled phospholipase C (PLC)/DGK route is a crucial signaling process in eukaryotic cells. Next to PLD, the PLC/DGK pathway is the second most important generator of PA in response to biotic and abiotic stresses. In eukaryotic cells, DGK, DAG, and PA are implicated in vital processes such as growth, development, and responses to environmental cues...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28222184/ecological-and-human-health-risks-associated-with-abandoned-gold-mine-tailings-contaminated-soil
#6
Veronica Mpode Ngole-Jeme, Peter Fantke
Gold mining is a major source of metal and metalloid emissions into the environment. Studies were carried out in Krugersdorp, South Africa, to evaluate the ecological and human health risks associated with exposure to metals and metalloids in mine tailings contaminated soils. Concentrations of arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and zinc (Zn) in soil samples from the area varied with the highest contamination factors (expressed as ratio of metal or metalloid concentration in the tailings contaminated soil to that of the control site) observed for As (3...
2017: PloS One
https://www.readbyqxmd.com/read/28219238/public-health-risk-of-arsenic-species-in-chicken-tissues-from-live-poultry-markets-of-guangdong-province-china
#7
Yuanan Hu, Wenfeng Zhang, Hefa Cheng, Shu Tao
Arsenic-based feed additives, such as roxarsone (ROX), are still legally and widely used in food animal production in many countries. This study was conducted to systematically characterize the content and speciation of arsenic in chicken tissues from live poultry markets and in commercial chicken feeds in Guangdong, a major poultry production and consumption province in China, and to assess the corresponding public health risk. The total arsenic contents in the commercial feeds could be modeled as a mixture of two log-normal distributions (geometric means: 0...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28216593/biomethylation-and-volatilization-of-arsenic-by-model-protozoan-tetrahymena-pyriformis-under-different-phosphate-regimes
#8
Xixiang Yin, Lihong Wang, Zhanchao Zhang, Guolan Fan, Jianjun Liu, Kaizhen Sun, Guo-Xin Sun
Tetrahymena pyriformis, a freshwater protozoan, is common in aquatic systems. Arsenic detoxification through biotransformation by T. pyriformis is important but poorly understood. Arsenic metabolic pathways (including cellular accumulation, effluxion, biomethylation, and volatilization) of T. pyriformis were investigated at various phosphate concentrations. The total intracellular As concentration increased markedly as the external phosphate concentration decreased. The highest concentration was 168.8 mg·kg(-1) dry weight, after exposure to As(V) for 20 h...
February 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28216132/arsenic-v-bioconcentration-kinetics-in-freshwater-macroinvertebrates-and-periphyton-is-influenced-by-ph
#9
Adeline R Lopez, David H Funk, David B Buchwalter
Arsenic is an important environmental pollutant whose speciation and mobility in freshwater food webs is complex. Few studies have characterized uptake and efflux rates of arsenic in aquatic benthic invertebrates. Further, we lack a fundamental understanding of how pH influences uptake kinetics in these organisms or how this key environmental variable could alter dietary exposure for primary consumers. Here we used a radiotracer approach to characterize arsenate accumulation dynamics in benthic invertebrates, the influence of pH on uptake in a subset of these organisms, and the influence of pH on uptake of arsenate by periphyton - an important food source at the base of aquatic food webs...
February 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28215805/private-well-groundwater-quality-in-west-virginia-usa-2010
#10
R K Law, M W Murphy, E Choudhary
The Centers for Disease Control and Prevention (CDC), in collaboration with the West Virginia Bureau of Public Health (BPH), initiated an investigation to characterize private well water quality in West Virginia. The objective was to better characterize private well water across various aquifer geologies by testing household drinking water samples and comparing them to EPA's National Primary Drinking Water Standards. The BPH selected ten counties representing three regions to capture geologically diverse areas that represent varying aquifer geology...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28210877/quantum-mechanical-treatment-of-as-3-thiol-model-compounds-implication-for-the-core-structure-of-as-iii-metallothionein
#11
Roobee Garla, Narinder Kaur, Mohinder Pal Bansal, Mohan Lal Garg, Biraja Prasad Mohanty
Exposure to inorganic arsenic (As) is one of the major health concerns in several regions around the world. Binding of As(III) with thiols is central to the mechanisms related to its toxicity, detoxification, and therapeutic effects. Due to its high thiol content, metallothionein (MT) is presumed to play an important role in case of arsenic toxicity. Consequences of these As-thiol interactions are not yet clear due to various difficulties in the characterization of arsenic bound proteins by spectroscopic techniques...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28210754/targeted-lipidomics-profiling-of-acute-arsenic-exposure-in-mice-serum-by-on-line-solid-phase-extraction-stable-isotope-dilution-liquid-chromatography-tandem-mass-spectrometry
#12
Chao-Yu Chen, Pinpin Lin, Ming-Hsien Tsai, Hui-Ling Lee
Lipidomics is the area of study dedicated to the comprehensive analysis and characterization of the functions and metabolism of lipids in biological samples. One of the most comprehensively studied classes of lipids is polyunsaturated fatty acids (PUFAs). Eicosanoids are a series of bioactive lipid mediators that are metabolized from PUFAs and generated majorly from the precursor arachidonic acid. This study identified the profiles of target eicosanoids after acute exposure to arsenic. The principle objective was to determine and validate 10 eicosanoids in mouse serum using on-line solid-phase extraction integrated with liquid chromatography-electrospray tandem mass spectrometry...
February 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28206677/human-adaptation-to-arsenic-in-andean-populations-of-the-atacama-desert
#13
Mario Apata, Bernado Arriaza, Elena Llop, Mauricio Moraga
OBJECTIVES: Quebrada Camarones, in the Atacama Desert, has the highest arsenic levels in the Americas (>1,000 µg/L). However, the Camarones people have subsisted in this adverse environment during the last 7,000 years and have not presented any epidemiological emergencies. Therefore, to solve this conundrum we compared the frequencies of four protective genetic variants of the AS3MT gene associated with efficient arsenic metabolization, between the living populations of Camarones and two other populations historically exposed to lower levels of arsenic...
February 16, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28206643/in-vivo-exposure-to-inorganic-arsenic-alters-differentiation-specific-gene-expression-of-adipose-derived-mesenchymal-stem-stromal-cells-in-c57bl-6j-mouse-model
#14
Joseph J Shearer, Manoel Figueiredo Neto, C Samuel Umbaugh, Marxa L Figueiredo
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28199894/height-and-blood-chemistry-in-adults-with-a-history-of-developmental-arsenic-poisoning-from-contaminated-milk-powder
#15
Takashi Yorifuji, Kenichi Matsuoka, Philippe Grandjean
BACKGROUND: Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955. OBJECTIVES: The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later...
February 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28195172/who-water-quality-standards-vs-synergic-effect-s-of-fluoride-heavy-metals-and-hardness-in-drinking-water-on-kidney-tissues
#16
Hewa M S Wasana, Gamage D R K Perera, Panduka De S Gunawardena, Palika S Fernando, Jayasundera Bandara
Despite WHO standards, waterborne diseases among the human being are rising alarmingly. It is known that the prolong exposure to contaminated water has major impact on public health. The effect of chemical contaminations in drinking water on human being is found to be chronic rather than acute and hence can be defined "consumption of contaminated drinking water could be a silent killer". As the WHO recommended water quality standards are only for individual element and synergic effects of trace metals and anions have not been considered, investigation of synergic effects of trace metals and anions and their effect on human being is of prime important research...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188207/use-of-endophytic-and-rhizosphere-bacteria-to-improve-phytoremediation-of-arsenic-contaminated-industrial-soils-by-autochthonous-betula-celtiberica
#17
Victoria Mesa, Alejandro Navazas, Ricardo González-Gil, Aida González, Nele Weyens, Béatrice Lauga, Jose Luis R Gallego, Jesús Sánchez, Ana Isabel Peláez
The aim of the study was to investigate the potential of indigenous arsenic-tolerant bacteria to enhance arsenic phytoremediation by autochthonous pseudometallophyte Betula celtiberica The first goal was to perform an initial analysis of the entire rhizosphere and endophytic bacterial communities of the above-named accumulator plant, including the cultivable bacterial species. B. celtiberica's microbiome was dominated by taxa related to Flavobacteriales, Burkholderiales, and Pseudomonadales, specially the Pseudomonas and Flavobacterium genera...
February 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28185737/prey-specific-determination-of-arsenic-bioaccumulation-and-transformation-in-a-marine-benthic-fish
#18
Wei Zhang, Li Zhang, Wen-Xiong Wang
The sediments from Chinese coastal waters contain relatively high concentrations of arsenic (As), mainly arsenate As(V), which may be transferred along the marine benthic food chain. The prey-specific determination of As bioaccumulation and transformation in marine benthic fish remains little known. In this study, we focused on a typical marine benthic food chain comprising of sediments, deposit-feeding invertebrates (polychaete Nereis succinea and clam Gafrarium tumidum) and goby fish Mugilogobius chulae. Graded exposed experiments using different As exposure durations and concentrations were conducted to examine their transformation rate and efficiency...
February 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28185733/evaluating-the-potential-health-risk-of-toxic-trace-elements-in-vegetables-accounting-for-variations-in-soil-factors
#19
Yang Yang, Weiping Chen, Meie Wang, Yanling Li, Chi Peng
Vegetable crop consumption is one of the main sources of dietary exposure to toxic trace elements (TEs). A paired survey of soil and vegetable samples was conducted in 589 agricultural sites in the Youxian prefecture, southern China, to investigate the effect of soil factors on the accumulation of arsenic, cadmium, mercury, and lead in different vegetables. A site-specific model was developed to estimate the health risk from vegetable consumption. The TE concentration varied in different plant species, and rape can be cultivated in contaminated areas for its potential use in restricting the transfer of TE from soil to edible plant parts...
February 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28179585/oncogenomic-disruptions-in-arsenic-induced-carcinogenesis
#20
REVIEW
Adam P Sage, Brenda C Minatel, Kevin W Ng, Greg L Stewart, Trevor J B Dummer, Wan L Lam, Victor D Martinez
Chronic exposure to arsenic affects more than 200 million people worldwide, and has been associated with many adverse health effects, including cancer in several organs. There is accumulating evidence that arsenic biotransformation, a step in the elimination of arsenic from the human body, can induce changes at a genetic and epigenetic level, leading to carcinogenesis. At the genetic level, arsenic interferes with key cellular processes such as DNA damage-repair and chromosomal structure, leading to genomic instability...
January 5, 2017: Oncotarget
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