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Arsenic exposure

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https://www.readbyqxmd.com/read/29228828/trace-elements-profiles-of-maternal-blood-umbilical-cord-blood-and-placenta-in-beijing-china
#1
Cui Zhou, Ran Zhang, Xueping Cai, Rong Xiao, Yu Huanling
Profiles of heavy metals chromium (Cr), manganese (Mn), arsenic (As), lead (Pb), cadmium (Cd) and micronutrients ferrum (Fe), copper (Cu), zinc (Zn), selenium (Se) in maternal and umbilical cord blood clots were investigated for assessing placenta function in the transport of micronutrients or heavy metal pollutants. Correlations between contents of elements in the two tissues were also analyzed. Results demonstrated significantly lower levels of Cr, Pb and Cd in umbilical cord blood clots than in maternal blood clots, and negative relationship between lead levels in maternal and umbilical cord blood (r = -0...
December 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29228391/arsenic-attenuates-heparin-binding-egf-like-growth-factor-egfr-signalling-that-promotes-matrix-metalloprotease-9-dependent-astrocyte-damage-in-the-developing-rat-brain
#2
Rajesh Kushwaha, Juhi Mishra, Sachin Tripathi, Waseem Raza, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhyay
We earlier reported that exposure to arsenic at concentrations in ground water of India attenuated glial fibrillary acidic protein (GFAP) during brain development. Here, we validated the effects and explored mechanism in cultured astrocytes and developing rat brain. We hypothesized participation of epidermal growth factor receptor (EGFR), known to regulate GFAP. We found that arsenic inactivated EGFR, marked by reduced phospho-EGFR in astrocytes. Screening EGFR ligands revealed an arsenic-mediated attenuation in cellular and secreted-Heparin-binding EGF-like growth factor (HB-EGF)...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29227952/public-health-risk-of-trace-metals-in-fresh-chicken-meat-products-on-the-food-markets-of-a-major-production-region-in-southern-china
#3
Yuanan Hu, Wenfeng Zhang, Gang Chen, Hefa Cheng, Shu Tao
Because most chickens are reared in intensive farms, where a range of feed additives are used routinely, concerns have been raised on the potential public health risk of chicken product consumption. This study was conducted to characterize the contents of trace metals in fresh chicken tissues (354 samples) on the food markets in Guangdong province of southern China, a major region of chicken production with heavy per capita chicken consumption, and to assess the public health risk from chronic dietary exposure to the trace metals through chicken consumption...
December 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29225007/high-sensitivity-quantitative-analysis-reveals-the-non-linear-relationship-between-the-dose-and-deposition-of-diphenylarsinic-acid-in-the-rat-central-nervous-system-following-its-subchronic-exposure
#4
Tomoyuki Masuda, Kazuhiro Ishii, Tomohiro Nakayama, Nobuaki Iwasaki, Yasuyuki Shibata, Akira Tamaoka
In the year 2003, the residents of Kamisu, Japan, were exposed to pentavalent organic arsenic diphenylarsinic acid (DPAA[V]) via their normal drinking water. Following the exposure, they developed cerebellar and brainstem symptoms. Although the relatively high dose of DPAA(V) is assumed to have caused their symptoms, the relationship between the exposed dose of DPAA(V) and the level of their deposition in the central nervous system (CNS) remains unclear. Using liquid chromatography-tandem mass spectrometry, we examined the deposition of DPAA(V) and its pentavalent metabolites in the CNS tissues of Crl:CD(SD) rats following the administration of DPAA(V) for 28days...
December 7, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29224186/secondhand-smoke-is-associated-with-heavy-metal-concentrations-in-children
#5
Li Li, Li Guo, Xingjie Chen, Mingli Xiang, Fang Yang, Jing-Chao Ren, Guang-Hui Zhang
Secondhand smoke (SHS) has adverse effects on health, particularly for children. Our purpose was to analyze the correlation between SHS exposure and heavy metal concentrations in children. The investigation was conducted in Xinxiang County, Henan Province, China, from August 2015 to December 2015. In total, 821 students (433 boys and 388 girls) were recruited, and the contents of heavy metals in their hair-including chromium, manganese, nickel, arsenic, lead, and cadmium-were detected by ICP-MS. The children's parents were informed, and a questionnaire was conducted, which included questions about smoking habits and demographic characteristics...
December 9, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29223816/cortex-and-hippocampus-dna-epigenetic-response-to-a-long-term-arsenic-exposure-via-drinking-water
#6
Xiaoyan Du, Meiping Tian, Xiaoxue Wang, Jie Zhang, Qingyu Huang, Liangpo Liu, Heqing Shen
The neurotoxicity of arsenic is a serious health problem, especially for children. DNA epigenetic change may be an important pathogenic mechanism, but the molecular pathway remains obscure. In this study, the weaned male Sprague-Dawly (SD) rats were treated with arsenic trioxide via drinking water for 6 months, simulating real developmental exposure situation of children. Arsenic exposure impaired the cognitive abilities, and altered the expression of neuronal activity-regulated genes. Total arsenic concentrations of cortex and hippocampus tissues were significantly increased in a dose-dependent manner...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29222648/the-level-of-toxic-elements-in-edible-crops-from-seleniferous-area-punjab-india
#7
Margarita G Skalnaya, Sumit K Jaiswal, Ranjana Prakash, N Tejo Prakash, Andrei R Grabeklis, Irina V Zhegalova, Feng Zhang, Xiong Guo, Alexey A Tinkov, Anatoly V Skalny
The primary objective of the present study was to assess the level of selenium and toxic trace elements in wheat, rice, maize, and mustard from seleniferous areas of Punjab, India. The content of selenium (Se) and toxic trace elements, including aluminum (Al), arsenic (As), cadmium (Cd), mercury (Hg), nickel (Ni), lead (Pb), and tin (Sn), in crop samples was assessed using inductively coupled plasma mass-spectrometry after microwave digestion of the samples. The obtained data demonstrate that cultivation of crops on seleniferous soils significantly increased Se level in wheat, mustard, rice, and maize by a factor of more than 590, 111, 85, and 64, respectively...
December 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29221727/epigenetic-mechanisms-in-developmental-neurotoxicity
#8
REVIEW
M Raciti, S Ceccatelli
The constant interplay between environment (including both exogenous and endogenous factors) and epigenome (defined as the combination of chromatin, its covalent modifications and noncoding RNAs) triggers epigenetic events that, by modulating gene expression, capture information about changes in the environment. In this mini review, we will focus on the neurodevelopmental implications of exposure to adverse prenatal milieu with emphasis on mechanistic and functional aspects. Several neurotoxic insults have been shown to affect epigenetics with negative consequences on the development of the nervous system; among them are methylmercury, lead, arsenic and cadmium, as well as excess of glucocorticoids...
December 5, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29217265/metabolism-and-disposition-of-arsenic-species-from-controlled-oral-dosing-with-sodium-arsenite-in-adult-female-cd-1-mice-i-pilot-study-to-determine-dosing-analytical-measurements-and-sampling-strategies
#9
Nathan C Twaddle, Michelle Vanlandingham, Mona I Churchwell, Daniel R Doerge
Arsenic (As) is ubiquitous in the earth's crust, with typical dietary intake in developed countries <1 μg/kg bw/d, and atypical groundwater exposures in developing countries approaching 50 μg/kg bw/d. Arsenic exposures are linked with human diseases and doses of toxicological concern are similar to typical dietary intake estimates. The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates...
December 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29214690/%C3%AE-lipoic-acid-inhibits-testicular-and-epididymal-oxidative-damage-and-improves-fertility-efficacy-in-arsenic-intoxicated-rats
#10
Papisetty Prathima, Ramanadhapuram Pavani, Sadepalli Sukeerthi, Sri Bhashyam Sainath
The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sperm viability, and sperm membrane integrity. Significant reduction in the activity levels of superoxide dismutase, catalase, and glutathione levels with a concomitant increase in the lipid peroxidation and protein carbonyl content in the testis and the cauda epididymis of arsenic-exposed rats...
December 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29212736/arsenic-exposure-in-relation-to-ischemic-stroke-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#11
Cari L Tsinovoi, Pengcheng Xun, Leslie A McClure, Vivian M O Carioni, John D Brockman, Jianwen Cai, Eliseo Guallar, Mary Cushman, Frederick W Unverzagt, Virginia J Howard, Ka He
BACKGROUND AND PURPOSE: The purpose of this case-cohort study was to examine urinary arsenic levels in relation to incident ischemic stroke in the United States. METHODS: We performed a case-cohort study nested within the REGARDS (REasons for Geographic and Racial Differences in Stroke) cohort. A subcohort (n=2486) of controls was randomly sampled within region-race-sex strata while all incident ischemic stroke cases from the full REGARDS cohort (n=671) were included...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29211769/arsenic-exposure-and-intestinal-microbiota-in-children-from-sirajdikhan-bangladesh
#12
Xiaoxi Dong, Natalia Shulzhenko, Julien Lemaitre, Renee L Greer, Kate Peremyslova, Quazi Quamruzzaman, Mahmudar Rahman, Omar Sharif Ibn Hasan, Sakila Afroz Joya, Mostofa Golam, David C Christiani, Andriy Morgun, Molly L Kile
BACKGROUND: Arsenic has antimicrobial properties at high doses yet few studies have examined its effect on gut microbiota. This warrants investigation since arsenic exposure increases the risk of many diseases in which gut microbiota have been shown to play a role. We examined the association between arsenic exposure from drinking water and the composition of intestinal microbiota in children exposed to low and high arsenic levels during prenatal development and early life. RESULTS: 16S rRNA gene sequencing revealed that children with high arsenic exposure had a higher abundance of Proteobacteria in their stool compared to matched controls with low arsenic exposure...
2017: PloS One
https://www.readbyqxmd.com/read/29209943/mapping-toxic-mineral-contamination-the-southern-oyster-drill-s-haemastoma-l-1767-as-evaluable-sentinel-species
#13
Giuseppa Di Bella, Gianluca Pizzullo, Giuseppe Daniel Bua, Angela Giorgia Potortì, Antonello Santini, Salvatore Giacobbe
The nickel, chromium, arsenic, cadmium, and lead content have been evaluated, by ICP-MS, in digestive gland of the amphiatlantic gastropod Stramonita haemastoma, sampled along the highly anthropized Gulf of Milazzo (Central Mediterranean). Concentrations notably higher than those reported in literature for other Mediterranean Muricidae have been recorded. The results also indicated a different impact in different sites, according to distribution and typology of human activities, whilst recorded seasonal variations might relate with rapid metabolic response...
December 6, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29207610/integration-of-micrornaome-proteomics-and-metabolomics-to-analyze-arsenic-induced-malignant-cell-transformation
#14
Youyou Zhou, Yanfu Wang, Juan Su, Zheng Wu, Chao Wang, Weiming Zhong, Xiaomei Liu, Linhui Cui, Xiaoyu Zhou, Yufang Ma, Yi Xin, Jianglin Zhang, Lisha Wu, Xing Hu, Xiang Chen, Cong Peng, MingYang Gao
Long-term exposure to arsenic has been linked to tumorigenesis in different organs and tissues, such as skin; however, the detailed mechanism remains unclear. In this present study, we integrated "omics" including microRNAome, proteomics and metabolomics to investigate the potential molecular mechanisms. Compared with non-malignant human keratinocytes (HaCaT), twenty-six miRNAs were significantly altered in arsenic-induced transformed cells. Among these miRNAs, the differential expression of six miRNAs was confirmed using Q-RT-PCR, representing potential oxidative stress genes...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29204679/gestational-exposure-to-inorganic-arsenic-ias3-alters-glutamate-disposition-in-the-mouse-hippocampus-and-ionotropic-glutamate-receptor-expression-leading-to-memory-impairment
#15
Janikua Nelson-Mora, Martha L Escobar, Luis Rodríguez-Durán, Lourdes Massieu, Teresa Montiel, Verónica M Rodríguez, Karina Hernández-Mercado, María E Gonsebatt
Early life exposure to environmental pollutants and toxic chemicals has been linked to learning and behavioral alterations in children. iAs exposure is associated with different types neurological disorders such as memory and learning impairment. iAs is methylated in the brain by the arsenic III-methyltransferase in a process that requires glutathione (GSH). The xCT-antiporter cell membrane transporter participates in the influx of cystine for GSH synthesis in exchange for glutamate in a 1:1 ratio. In CD-1 mice gestationally exposed to 20 ppm of sodium arsenite in drinking water, we have previously observed up-regulation of xCT in the male mouse hippocampus which caused glutamatergic synapse alterations affecting learning and memory processes...
December 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29203196/hepatorenal-protective-effects-of-medicinal-herbs-in-an-gong-niu-huang-wan-agnh-against-cinnabar-and-realgar-induced-oxidative-stress-and-inflammatory-damage-in-mice
#16
Ao Li, Jing-Yao Zhang, Xiao Xiao, Songsong Wang, Jian-Bo Wan, Yu-Shuang Chai, Peng Li, Yitao Wang
An-Gong-Niu-Huang Wan (AGNH) is a famous traditional Chinese medicine prescription that contains cinnabar (HgS) and realgar (As2S2); the clinical practice of AGNH is hindered because both mercury and arsenic are hepatorenal toxic metalloids. It is noted that the cinnabar and realgar in AGNH are not used alone, but rather combined with different kinds of medicinal herbs as a formula to use. In this study, we evaluated the hepatorenal protective effects of the medicinal herbs in AGNH after co-exposure to cinnabar and realgar for 4 weeks in mice...
December 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29202269/opportunities-and-challenges-in-the-use-of-mineral-nutrition-for-minimizing-arsenic-toxicity-and-accumulation-in-rice-a-critical-review
#17
REVIEW
Saifullah, Saad Dahlawi, Asif Naeem, Muhammad Iqbal, Muhammad Ansar Farooq, Sadia Bibi, Zed Rengel
Growing rice on arsenic (As)-contaminated soil or irrigating with As-contaminated water leads to significant accumulation of As in grains. Moreover, rice accumulates more As into grains than other cereal crops. Thus, rice consumption has been identified as a major route of human exposure to As in many countries. Inorganic As species are carcinogenic and could pose a considerable health risk to humans even at low dietary concentration. Genotypic variation and concentration of nutrients such as iron, manganese, phosphate, sulfur and silicon are the two main factors that affect As accumulation in rice grains...
December 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29198881/role-of-arsenic-exposure-in-adipose-tissue-dysfunction-and-its-possible-implication-in-diabetes-pathophysiology
#18
REVIEW
Kaviyarasi Renu, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Sankarganesh Arunachlam, Abilash V G
Exposure to arsenic in drinking water can stimulate a diverse number of diseases that originate from impaired lipid metabolism in adipose and glucose metabolism, leading to insulin resistance. Arsenic inhibits differentiation of adipocyte and mediates insulin resistance with diminutive information on arsenicosis on lipid storage and lipolysis. This review focused on different mechanisms and pathways involved in adipogenesis and lipolysis in adipose tissue during arsenic-induced diabetes. Though arsenic is known to cause type2 diabetes through different mechanisms, the role of adipose tissue in causing type2 diabetes is still unclear...
November 30, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29197518/association-between-inefficient-arsenic-methylation-capacity-and-demographic-characteristics-on-the-risk-of-skin-lesions
#19
Hifza Rasheed, Paul Kay, Rebecca Slack, Yun Yun Gong
This study was conducted in rural Pakistan to assess the dose-response relationship between skin lesions and arsenic exposure and their variation by demographic characteristics. The study included 398 participants (66 participants with skin lesions and 332 without) residing in six previously unstudied villages exposed to ground water arsenic in the range of <1 to 3090μgL-1. The skin lesions identification process involved interview and physical examinations of participants followed by confirmation by a physician according to UNICEF criteria...
November 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29194429/hazard-ranking-method-for-populations-exposed-to-arsenic-in-private-water-supplies-relation-to-bedrock-geology
#20
Helen Crabbe, Tony Fletcher, Rebecca Close, Michael J Watts, E Louise Ander, Pauline L Smedley, Neville Q Verlander, Martin Gregory, Daniel R S Middleton, David A Polya, Mike Studden, Giovanni S Leonardi
Approximately one million people in the UK are served by private water supplies (PWS) where main municipal water supply system connection is not practical or where PWS is the preferred option. Chronic exposure to contaminants in PWS may have adverse effects on health. South West England is an area with elevated arsenic concentrations in groundwater and over 9000 domestic dwellings here are supplied by PWS. There remains uncertainty as to the extent of the population exposed to arsenic (As), and the factors predicting such exposure...
December 1, 2017: International Journal of Environmental Research and Public Health
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