keyword
MENU ▼
Read by QxMD icon Read
search

Arsenic exposure

keyword
https://www.readbyqxmd.com/read/28821860/gaba-accretion-reduces-lsi-1-and-lsi-2-gene-expressions-and-modulates-physiological-responses-in-oryza-sativa-to-provide-tolerance-towards-arsenic
#1
Navin Kumar, Arvind Kumar Dubey, Atul Kumar Upadhyay, Ambedkar Gautam, Ruma Ranjan, Saripella Srikishna, Nayan Sahu, Soumit Kumar Behera, Shekhar Mallick
GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed that accumulation of GABA reduced the expressions of Lsi-1 and Lsi-2 transporter genes, which ultimately decreased the accumulation of As in rice seedlings. The accumulation of GABA also modulated the gene expression of GABA shunt pathway and activity of antioxidant enzymes, which strongly induced the tolerance in plants...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820073/immunomodulatory-role-of-arsenic-on-regulatory-t-cells
#2
Rizwanul Haque, Archana Chaudhary, Nadra Sadaf
Background and objective-Chronic Arsenic (As) exposure continued to be a cause of major problem associated with different kind of diseases including skin problem and different types of cancer. As exposure leads to numerous other pathological conditions that affect millions of people worldwide on a regular basis. It was recently established that As toxicity affects immune system and modulate the function and survival of cells involved in immune regulation. Arsenic trioxide (As2O3) was reported to be an effective apoptosis inducer in a variety of cell types...
August 17, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28819764/secad-and-egf-levels-increased-in-urine-of-non-ferrous-metal-workers-and-medium-of-uroepithelial-cell-line-treated-by-arsenic
#3
Jieyu Liu, Peiyu Jin, Shengnan Liu, Fei Wang, Xiaoyan Wang, Li Yang, Shuhua Xi
Inorganic arsenic (iAs) is a carcinogen and could increase the risks of bladder, lung, and skin cancer. Mining and smelting of non-ferrous metals are common occupational arsenic exposures. In this study, 125 individuals working in non-ferrous metal smelting plants were separated into two groups according to urinary total arsenic (TAs) levels: group 1, TAs < 100 μg/g Cr; group 2, TAs ≥ 100 μg/g Cr. Demographic characteristics of participants were obtained by questionnaire interview. Levels of E-cadherin soluble ectodomain fragment (sEcad) and epidermal growth factor (EGF) in workers urine were determined by ELISA test...
August 17, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28818805/association-between-consumption-of-private-well-water-contaminated-by-low-levels-of-arsenic-and-dysglycemia-in-a-rural-region-of-quebec-canada
#4
Éric Lampron-Goulet, Fabien Gagnon, Marie-France Langlois
The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada...
August 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28815697/case-control-study-of-chronic-low-level-exposure-of-inorganic-arsenic-species-and-non-melanoma-skin-cancer
#5
Tae-Hoon Kim, Jeong-Wook Seo, Young-Seoub Hong, Ki-Hoon Song
A significant relationship between arsenic exposure and non-melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitative exposure assessment of arsenic species in NMSC patients. To validate the contribution of each arsenic species to NMSC, we compared the creatinine-adjusted urinary concentration of arsenic species in NMSC patients and community controls...
August 16, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28813693/thyrotoxicity-of-arsenate-and-arsenite-on-juvenile-mice-at-organism-subcellular-and-gene-levels-under-low-exposure
#6
Hong-Jie Sun, Shi-Wei Li, Chao Li, Wen-Qian Wang, Hong-Bo Li, Lena Q Ma
Arsenic contamination in drinking water is a worldwide issue, posing threat to human health. Arsenic is an endocrine system disruptor, however, limited information is available regarding its long-term effects on thyroid endocrine system at low exposure. In this study, we assessed the thyroid toxicity of arsenate (AsV) and arsenite (AsIII) at 10-100 μg L(-1) in juvenile mice after 8-week of exposure via drinking water. After 1-2 week, AsV and AsIII had little influence on thyroxine (T4) level (56.3-64.7 μg L(-1)) in mouse blood compared to control mice at 57...
August 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28810224/simultaneous-leaching-of-arsenite-arsenate-selenite-and-selenate-and-their-migration-in-tunnel-excavated-sedimentary-rocks-i-column-experiments-under-intermittent-and-unsaturated-flow
#7
Carlito Baltazar Tabelin, Ryosuke Sasaki, Toshifumi Igarashi, Ilhwan Park, Shuichi Tamoto, Takahiko Arima, Mayumi Ito, Naoki Hiroyoshi
Rocks excavated in tunnel construction projects for roads and railways throughout Japan often leached out hazardous trace elements like arsenic (As) and selenium (Se) upon their exposure to the environment. In nature, the various oxyanionic species of As and Se not only coexist but also exhibit contrasting adsorption-desorption behaviors, so speciation is a crucial factor in their migration through natural geologic media. In this study, the leaching and transport of arsenite (As(III)), arsenate (As(V)), selenite (Se(IV)) and selenate (Se(VI)) in four tunnel-excavated rocks from the Cretaceous-Paleocene Yezo forearc basin were investigated using laboratory column experiments supplemented by batch leaching experiments...
July 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28809551/direct-speciation-analysis-of-arsenic-in-whole-blood-and-blood-plasma-at-low-exposure-levels-by-hydride-generation-cryotrapping-inductively-coupled-plasma-mass-spectrometry
#8
Tomáš Matoušek, Zhifeng Wang, Christelle Douillet, Stanislav Musil, Miroslav Stýblo
A method for analysis of toxicologically important arsenic species in blood plasma and whole blood by selective hydride generation with cryotrapping (HG-CT) coupled either to atomic absorption (AAS) with a quartz multiatomizer or to inductively coupled plasma mass spectrometry (ICP-MS) has been validated. Sample preparation which involved only 5 times dilution with addition of Triton X-100, Antifoam B and L-cysteine suppressed excessive foaming in a hydride generator. Calibration slopes for whole blood and blood plasma spiked with arsenate, monomethylarsonate and dimethylarsinate at 0...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28803342/alleviation-of-arsenic-induced-pulmonary-oxidative-damage-by-gspe-as-shown-during-in-vivo-and-in-vitro-experiments
#9
Meng Wei, Fangming Guo, Dongsheng Rui, Haixia Wang, Gangling Feng, Shugang Li, Guanling Song
A long-term exposure to arsenic may lead to lung damage due to oxidative stress. In this context, GSPE can play a major role as a strong antioxidant. Our study attempted to reveal the connection between arsenic-induced lung injury and the antagonistic effect of GSPE. For this purpose, BEAS-2B cells and Kunming mice were exposed to different dosages of As2O3 and GSPE. Oxidative stress indicators were detected both in vivo and in vitro. Cell survival rate and morphological changes in the lung tissue (H&E staining) were evaluated as well...
August 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28802093/clinical-aspects-of-opium-adulterated-with-lead-in-iran-a-review
#10
Samira Alinejad, Jan Aaseth, Mohammad Abdollahi, Hossein Hassanian-Moghaddam, Omid Mehrpour
Adulteration of drugs with poisonous substances during production or consumption has caused numerous health problems. Among contaminants that have the potential of producing poisonous effects are the heavy metals lead, arsenic and thallium that make up an important group of toxic substances. The emergence of these new health problems related to opioid abuse has precipitated this MiniReview on the status of the most hazardous and common opioid adulterants. In fact, adulterated opium is a major public health problem and can threaten the health of users...
August 12, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28796632/the-association-of-arsenic-metabolism-with-cancer-cardiovascular-disease-and-diabetes-a-systematic-review-of-the-epidemiological-evidence
#11
Chin-Chi Kuo, Katherine A Moon, Shu-Li Wang, Ellen Silbergeld, Ana Navas-Acien
BACKGROUND: The available evidence on the role of arsenic metabolism in individual susceptibility to the development of cancer, cardiovascular disease, and diabetes has not been formally and comprehensively reviewed. OBJECTIVES: Our goal was to systematically investigate the association of arsenic metabolism with cancer, cardiovascular disease, and diabetes-related outcomes in epidemiologic studies. As a secondary objective, we characterized the variation of arsenic metabolism in different populations worldwide...
August 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28793237/fetal-sex-dependent-genomic-responses-in-the-circulating-lymphocytes-of-arsenic-exposed-pregnant-women-in-new-hampshire
#12
Paige A Bommarito, Elizabeth Martin, Lisa Smeester, Thomas Palys, Emily R Baker, Margaret R Karagas, Rebecca C Fry
Exposure to inorganic arsenic (iAs) during pregnancy is associated with adverse health outcomes present both at birth and later in life. A mechanism may include epigenetic and genomic alteration in fetal genes involved in immune functioning. To investigate the role of the maternal immune response to in utero iAs exposure, we conducted an analysis of immune-related genes in pregnant women from the New Hampshire Birth Cohort Study. A set of 31 genes were identified with altered expression in association with levels of urinary total arsenic, urinary iAs, urinary monomethylated arsenic and urinary dimethylated arsenic...
August 6, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28791301/effects-of-chronic-exposure-to-sodium-arsenite-on-expressions-of-vegf-and-vegfr2-proteins-in-the-epididymis-of-rats
#13
Dai Yan-Ping, Gao Xiao-Qin, Ma Xiao Ping, Yue Ying Quan
OBJECTIVE: To study the expressions of VEGF and VEGFR2 at protein level in the epididymis of rats with arsenism. METHODS: Forty male Sprague-Dawley rats were randomly divided into four groups: the high dose arsenic infected group (60.0 mg/L in water), the middle dose arsenic infected group (12.0 mg/L in water), the low dose arsenic infected group (2.4 mg/L in water), and the control group (distilled water). Rats were treated with arsenic through drinking water for 6 consecutive months...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28783109/health-risks-and-contamination-levels-of-heavy-metals-in-dusts-from-parks-and-squares-of-an-industrial-city-in-semi-arid-area-of-china
#14
Xiufeng Han, Xinwei Lu, Yongfu Wu
The contamination characteristics and health risk of barium (Ba), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), vanadium (V), zinc (Zn), arsenic (As), mercury (Hg), and cadmium (Cd) in samples of dust gathered from squares and parks of Baotou city, an industrial city situated in a semi-arid location of the northwest China were investigated. The contents of Ba, Co, Cr, Cu, Mn, Ni, V, Pb, and Zn in the collected dust samples were determined using X-ray fluorescence spectrometry, while the contents of As and Hg in the dust were investigated by use of the ICP-MS...
August 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28781895/suicide-behaviour-and-arsenic-levels-in-drinking-water-a-possible-association-a-review-of-the-literature-about-the-effects-of-arsenic-contamination-in-drinking-water-on-suicides
#15
REVIEW
Gianmarco Troiano, Isabella Mercurio, Paola Melai, Nicola Nante, Massimo Lancia, Mauro Bacci
BACKGROUND: A considerable part of the global population is exposed to arsenic-contaminated drinking water which is the main source of inorganic arsenic(As) exposure in humans. Arsenic exposure interferes with the action of enzymes, essential cations, and transcriptional events in cells throughout the body, and a multitude of multisystemic non-cancer effects might ensue. The aim of our review was to evaluate the effects of arsenic contamination in drinking water on suicides rates. METHODS: A systematic literature search (English written literature) was conducted in electronic databases MEDLINE, SCOPUS...
2017: Egyptian journal of forensic sciences
https://www.readbyqxmd.com/read/28776197/long-term-exposure-of-immortalized-keratinocytes-to-arsenic-induces-emt-impairs-differentiation-in-organotypic-skin-models-and-mimics-aspects-of-human-skin-derangements
#16
R Weinmuellner, K Kryeziu, B Zbiral, K Tav, B Schoenhacker-Alte, D Groza, L Wimmer, M Schosserer, F Nagelreiter, S Rösinger, M Mildner, E Tschachler, M Grusch, J Grillari, P Heffeter
Arsenic is one of the most important human carcinogens and environmental pollutants. However, the evaluation of the underlying carcinogenic mechanisms is challenging due to the lack of suitable in vivo and in vitro models, as distinct interspecies differences in arsenic metabolism exist. Thus, it is of high interest to develop new experimental models of arsenic-induced skin tumorigenesis in humans. Consequently, aim of this study was to establish an advanced 3D model for the investigation of arsenic-induced skin derangements, namely skin equivalents, built from immortalized human keratinocytes (NHEK/SVTERT3-5)...
August 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28776191/water-consumption-as-source-of-arsenic-chromium-and-mercury-in-children-living-in-rural-yucatan-mexico-blood-and-urine-levels
#17
F Arcega-Cabrera, L F Fargher, I Oceguera-Vargas, E Noreña-Barroso, L Yánez-Estrada, J Alvarado, L González, R Moo-Puc, N Pérez-Herrera, M Quesadas-Rojas, S Pérez-Medina
Studies investigating the correlation between metal content in water and metal levels in children are scarce worldwide, but especially in developing nations. Therefore, this study investigates the correlation between arsenic, chromium, and mercury concentrations in drinking and cooking water and in blood and urine samples collected from healthy and supposedly non-exposed children from a rural area in Yucatan, Mexico. Mercury in water shows concentrations above the recommended World Health Organization (WHO) value for drinking and cooking water...
August 4, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28772151/concentrations-of-urinary-arsenic-species-in-relation-to-rice-and-seafood-consumption-among-children-living-in-spain
#18
Antonio J Signes-Pastor, Jesus Vioque, Eva M Navarrete-Muñoz, Manus Carey, Manoli's García de la Hera, Jordi Sunyer, Maribel Casas, Isolina Riaño-Galán, Adonina Tardón, Sabrina Llop, Rubén Amorós, Margaret R Karagas, Andrew A Meharg
Inorganic arsenic (i-As) has been related to wide-ranging health effects in children, leading to lifelong concerns. Proportionally, dietary i-As exposure dominates in regions with low arsenic drinking water. This study aims to investigate the relation between rice and seafood consumption and urinary arsenic species during childhood and to assess the proportion of urinary i-As metabolites. Urinary arsenic species concentration in 400 4-year-old children living in four geographical areas of Spain, in addition to repeated measures from 100 children at 7 years of age are included in this study...
July 31, 2017: Environmental Research
https://www.readbyqxmd.com/read/28771557/low-moderate-urine-arsenic-and-biomarkers-of-thrombosis-and-inflammation-in-the-strong-heart-study
#19
Katherine A Moon, Ana Navas-Acien, Maria Grau-Pérez, Kevin A Francesconi, Walter Goessler, Eliseo Guallar, Jason G Umans, Lyle G Best, Jonathan D Newman
The underlying pathology of arsenic-related cardiovascular disease (CVD) is unknown. Few studies have evaluated pathways through thrombosis and inflammation for arsenic-related CVD, especially at low-moderate arsenic exposure levels (<100 μg/L in drinking water). We evaluated the association of chronic low-moderate arsenic exposure, measured as the sum of inorganic and methylated arsenic species in urine (ΣAs), with plasma biomarkers of thrombosis and inflammation in American Indian adults (45-74 years) in the Strong Heart Study...
2017: PloS One
https://www.readbyqxmd.com/read/28769045/arsenic-exposure-impels-cd4-commitment-in-thymus-and-suppress-t-cell-cytokine-secretion-by-increasing-regulatory-t-cells
#20
Ruchi Gera, Vikas Singh, Sumonto Mitra, Anuj Kumar Sharma, Alok Singh, Arunava Dasgupta, Dhirendra Singh, Mahadeo Kumar, Pankaj Jagdale, Satyakam Patnaik, Debabrata Ghosh
Arsenic is globally infamous for inducing immunosuppression associated with prevalence of opportunistic infection in exposed population, although the mechanism remains elusive. In this study, we investigate the effect of arsenic exposure on thymocyte lineage commitment and the involvement of regulatory T cells (Treg) in arsenic-induced immunosuppression. Male Balb/c mice were exposed to 0.038, 0.38 and 3.8 ppm sodium arsenite for 7, 15 and 30 days through oral gavage. Arsenic exposure promoted CD4 lineage commitment in a dose dependent manner supported by the expression of ThPOK in thymus...
August 2, 2017: Scientific Reports
keyword
keyword
27023
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"