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Arsenic exposure

Christophe Glorieux, Pedro Buc Calderon
Background: Pro-oxidant drugs have been proposed for treating certain cancers but the resistance developed by cancer cells to oxidative stress limits its potential use in clinics. To understand the mechanisms underlying resistance to oxidative stress, we found that the chronic exposure to an H2 O2 -generating system (ascorbate/menadione, Asc/Men) or catalase overexpression (CAT3 cells) increased the resistance of cancer cells to oxidative stress, likely by increasing the antioxidant status of cancer cells...
2018: Cancer Cell International
Pablo Olmedo, Walter Goessler, Stefan Tanda, Maria Grau-Perez, Stephanie Jarmul, Angela Aherrera, Rui Chen, Markus Hilpert, Joanna E Cohen, Ana Navas-Acien, Ana M Rule
BACKGROUND: Electronic cigarettes (e-cigarettes) generate an aerosol by heating a solution (e-liquid) with a metallic coil. Whether metals are transferred from the coil to the aerosol is unknown. OBJECTIVE: Our goal was to investigate the transfer of metals from the heating coil to the e-liquid in the e-cigarette tank and the generated aerosol. METHODS: We sampled 56 e-cigarette devices from daily e-cigarette users and obtained samples from the refilling dispenser, aerosol, and remaining e-liquid in the tank...
February 21, 2018: Environmental Health Perspectives
Hongxiu Liu, Shi Lu, Bin Zhang, Wei Xia, Wenyu Liu, Yang Peng, Hongling Zhang, Kangbing Wu, Shunqing Xu, Yuanyuan Li
Maternal arsenic exposure leads to adverse birth outcomes, but the critical window of this susceptibility keeps unclear. To determine whether the associations between maternal arsenic exposure and birth outcomes were trimester-specific, we conducted a birth cohort study of 1390 women from 2014 to 2016 in Wuhan, China. We examined associations between total urinary arsenic concentrations in three trimesters and birth weight, birth length and the risk of small for gestational age (SGA), and the differences of these associations across trimesters using generalized estimating equations...
February 17, 2018: Environmental Pollution
Shunhua Wu, Jing Li, Xiang Jin
Long-term consumption of sodium arsenite contaminated water can cause endemic arsenic disease. The proteome profile changes of liver fibrosis after exposure to arsenite containing water remain unclear. In this study, Sprague-Dawley (SD) male rats were treated with sodium arsenite (iAs3+), using a daily dose of 1.36 mg/kg body weight (medium dose group, M), 2.73 mg/kg body weight (high dose group, H) or deionized water (control group, C). Isobaric tags for relative and absolute quantitation (iTRAQ) were used to identify the different abundant proteins (DAPs) after arsenic-induced liver fibrosis...
February 19, 2018: Scientific Reports
Paloma Kachel Gusso-Choueri, Giuliana Seraphim de Araújo, Ana Carolina Feitosa Cruz, Tatiana Roselena de Oliveira Stremel, Sandro Xavier de Campos, Denis Moledo de Souza Abessa, Ciro Alberto de Oliveira Ribeiro, Rodrigo Brasil Choueri
The risk of metals and As in seafood for traditional populations living in a Marine Protected Areas (MPA) is seldom assessed, although the risk of human exposure to contaminants is one of the indicators associated with the socioeconomic goals of MPAs. The current study aimed to estimate the potential risk of some metals (Cd, Pb, and Zn) and arsenic (As) for human health through the ingestion of fish locally harvested in a Ramsar site, the Cananéia-Iguape-Peruíbe Environmental Protected Area (APA-CIP). Previous studies showed environmental impacts in this area due to former mining activities and urbanization...
February 14, 2018: Science of the Total Environment
Beryl Vedha Yesudhason, Paulkumar Kanniah, Elaiya Raja Subramanian, Vasanthakumar Ponesakki, Veeraragavan Rajendiran, Sudhakar Sivasubramaniam
Both the evaluation and the determination of toxicity of chemical substances present in the environment have implications in human health. In this present study, the natural phenomenon named autotomy, a self-defense mechanism employed by several animals against the toxic chemical contaminants, was considered to assess the toxicity of different chemical substances. We investigated the effects of glucose, sodium chloride, kanamycin, mercuric chloride, arsenic trioxide, and lead oxide on the phenotypes of earthworm Eudrilus eugeniae...
February 16, 2018: Environmental Monitoring and Assessment
Maria Argos, Lin Tong, Shantanu Roy, Mekala Sabarinathan, Alauddin Ahmed, Md Tariqul Islam, Tariqul Islam, Muhammad Rakibuz-Zaman, Golam Sarwar, Hasan Shahriar, Mahfuzar Rahman, Md Yunus, Joseph H Graziano, Farzana Jasmine, Muhammad G Kibriya, Xiang Zhou, Habibul Ahsan, Brandon L Pierce
Identifying gene-environment interactions is a central challenge in the quest to understand susceptibility to complex, multi-factorial diseases. Developing an understanding of how inter-individual variability in inherited genetic variation alters the effects of environmental exposures will enhance our knowledge of disease mechanisms and improve our ability to predict disease and target interventions to high-risk sub-populations. Limited progress has been made identifying gene-environment interactions in the epidemiological setting using existing statistical approaches for genome-wide searches for interaction...
February 16, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
S M Müller, F Ebert, J Bornhorst, H-J Galla, K A Francesconi, T Schwerdtle
Lipid-soluble arsenicals, so-called arsenolipids, have gained a lot of attention in the last few years because of their presence in many seafoods and reports showing substantial cytotoxicity emanating from arsenic-containing hydrocarbons (AsHCs), a prominent subgroup of the arsenolipids. More recent in vivo and in vitro studies indicate that some arsenolipids might have adverse effects on brain health. In the present study, we focused on the effects of selected arsenolipids and three representative metabolites on the blood-cerebrospinal fluid barrier (B-CSF-B), a brain-regulating interface...
February 6, 2018: Journal of Trace Elements in Medicine and Biology
Roxane Guillod-Magnin, Beat J Brüschweiler, Rafael Aubert, Max Haldimann
Inorganic arsenic (iAs) is a contaminant present in food, especially in rice and rice-based products. Toxicity of arsenic compounds (As) depends on species and oxidative state. Inorganic arsenic species, such as arsenite (As(III)) and arsenate (As(V)), are more bioactive and toxic than organic arsenic species, like methylarsonic acid (MMA(V)) and dimethylarsinic acid (DMA(V)) or arsenosugars and arsenobetaine. An ion chromatography-inductively coupled plasma-mass spectroscopy (IC-ICP-MS) method was developed to separate the four following arsenic anions: As(III), As(V), MMA(V) and DMA(V)...
February 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Airton da Cunha Martins, Maria Fernanda Hornos Carneiro, Denise Grotto, Joseph A Adeyemi, Fernando Barbosa
Arsenic (As), cadmium (Cd), and mercury (Hg) are toxic elements widely distributed in the environment. Exposure to these elements was attributed to produce several acute and chronic illnesses including hypertension. The aim of this review is to provide a summary of the most frequently proposed mechanisms underlying hypertension associated with As, Cd, and Hg exposure including: oxidative stress, impaired nitric oxide (NO) signaling, modified vascular response to neurotransmitters and disturbed vascular muscle Ca2+ signaling, renal damage, and interference with the renin-angiotensin system...
February 15, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Vicent Yusà, Rosa Pérez, Alfredo Sánchez, Olga Pardo, Marta Roca
We present a new approach to arsenic (As) risk assessment using biomonitoring. In this pilot study we determined the levels of total and speciated urinary arsenicin 109 Spanish school children aged between 6 and 11 years, and interpreted these concentrations in a risk assessment context. The geometric mean (GM) for total As (TAs) was 33.82 μ/L. The order of occurrence and average concentrations of the different species was arsenobetaine (AsB) (100%, 15 μg/L), dimethylarsinic (DMA) (97%, 8.32 μg/L), monomethylarsonic (MMA) (26%, 0...
February 11, 2018: Science of the Total Environment
Citlalli Osorio-Yáñez, Bizu Gelaye, Daniel A Enquobahrie, Chunfang Qiu, Michelle A Williams
Pregnancy is a period when the mother and her offspring are susceptible to the toxic effects of metals. We investigated associations of intake of frequently consumed foods with urinary metals concentrations among pregnant women in the Pacific Northwest. We measured urinary cadmium (U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot urine samples in early pregnancy (15 weeks of gestation, on average) among 558 women from Seattle and Tacoma, Washington. We assessed periconceptional dietary intake using a semi-quantitative food frequency questionnaire (FFQ)...
February 10, 2018: Environmental Pollution
Yanfang Gao, Zhiqiang Zhao, Linqing Yang, Xinxia Liu, Xiumei Xing, Huimin Zhang, Jianpei Yun, Xiaoyan Ou, Xiaolin Su, Yao Lu, Yi Sun, Yarui Yang, Jun Jiang, Dong Cui, Zhixiong Zhuang, Yun He
Epidemiologic study has suggested that arsenic exposure is positively related to increased blood pressure. However, the underlying mechanism concerning interaction between genetic polymorphisms and arsenic exposure remains unclear. In present study, within 395 Chinese, the effects of interaction between arsenic exposure and CCM3 gene polymorphisms on elevation of blood pressure were probed by multiple Logistic regression models after adjusting for confounding factors. Firstly, we found that serum arsenic was positively associated with blood pressure, cholesterol, glucose and C-reactive protein...
January 12, 2018: Oncotarget
Liang Chi, Bei Gao, Pengcheng Tu, Chih-Wei Liu, Jingchuan Xue, Yunjia Lai, Hongyu Ru, Kun Lu
Arsenic (As) contamination in water or food is a global issue affecting hundreds of millions of people. Although As is classified as a group 1 carcinogen and is associated with multiple diseases, the individual susceptibility to As-related diseases is highly variable, such that a proportion of people exposed to As have higher risks of developing related disorders. Many factors have been found to be associated with As susceptibility. One of the main sources of the variability found in As susceptibility is the variation in the host genome, namely, polymorphisms of many genes involved in As transportation, biotransformation, oxidative stress response, and DNA repair affect the susceptibility of an individual to As toxicity and then influence the disease outcomes...
February 10, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
Hong Pan, Huijie Hou, Yao Shi, Hongbo Li, Jing Chen, Linling Wang, John C Crittenden
The catalytic oxidation of arsenite (As(III)) to arsenate (As(V)) and the removal of arsenic (As) in an iron loaded silicon carbide (Fe/SiC) system under microwave (MW) irradiation were studied. Fe/SiC was synthesized by electro-deposition and its capability of activating molecular oxygen was also characterized. Highly efficient As(III) removal in a wide pH range of 2.5-9.5 was achieved, involving oxidation by reactive oxidation species (OH and O2-) induced by MW irradiation and adsorption by the generated Fe (hrdro)oxide precipitates...
February 8, 2018: Chemosphere
Ricardo Núñez, M Ángeles García, Julián Alonso, M Julia Melgar
Currently, metal bioaccumulation in fish is increasing and is a cause of concern due to toxicity. Total arsenic, cadmium and lead concentrations in fresh and processed tuna (110 samples) marketed in Galicia (NW Spain) were determined by ICP-MS spectrometry. The average concentrations of As and Cd, 3.78 and 0.024 mg kg-1 w.w., respectively, in fresh tuna were statistically significantly higher than those in processed tuna (p < 0.001). The contents in processed tuna were 0.295-7.85 mg kg-1 for As and ND-0...
January 29, 2018: Science of the Total Environment
Ching-Ping Liang, Jui-Sheng Chen, Yi-Chi Chien, Ching-Fang Chen
A long-term groundwater quality survey in northeastern Taiwan's Lanyang Plain has revealed obvious contamination of the groundwater in some areas, with measured As concentrations in excess of the acceptable level of 10μg/L. Efforts for assessing the health risk associated with the intake of As through the drinking of contaminated groundwater are a necessary part of the important work of health risk management. However, the standard approach to assessing risks to human health does not adequately account for spatial heterogeneity in the measured As concentrations...
February 5, 2018: Science of the Total Environment
Fabrizio Minichilli, Fabrizio Bianchi, Anna Maria Ronchi, Francesca Gorini, Elisa Bustaffa
Arsenic is ubiquitous and has a potentially adverse impact on human health. We compared the distribution of concentrations of urinary inorganic arsenic plus methylated forms (uc(iAs+MMA+DMA)) in four Italian areas with other international studies, and we assessed the relationship between uc(iAs+MMA+DMA) and various exposure factors. We conducted a human biomonitoring study on 271 subjects (132 men) aged 20-44, randomly sampled and stratified by area, gender, and age. Data on environmental and occupational exposure and dietary habits were collected through a questionnaire...
February 9, 2018: International Journal of Environmental Research and Public Health
Tammy R Dugas
To date, numerous clinical studies examining correlations between oxidative stress biomarkers and cardiovascular diseases (CVD) have repeatedly suggested a role for oxidant injury in the pathogenesis of diseases such as atherosclerosis. Despite this, antioxidant supplementation trials have not demonstrated a reduction in disease progression. Nevertheless, small animal and epidemiological studies have linked exposures to certain toxicants with increased CVD risk involving putative oxidative stress mechanisms...
February 2018: Current Opinion in Toxicology
Melinda L Erickson, Helen F Malenda, Emily C Berquist
Naturally occurring arsenic can adversely affect water quality in geologically diverse aquifers throughout the world. Chronic exposure to arsenic via drinking water is a human health concern due to risks for certain cancers, skin abnormalities, peripheral neuropathy, and other negative health effects. Statewide in Minnesota, USA, 11% of samples from new drinking water wells have arsenic concentrations exceeding 10 μg/L; in certain counties more than 35% of tested samples exceed 10 μg/L arsenic. Since 2008 Minnesota well code has required testing water from new wells for arsenic...
February 8, 2018: Ground Water
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