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https://www.readbyqxmd.com/read/28431356/heavy-metals-pollution-levels-and-children-health-risk-assessment-of-yerevan-kindergartens-soils
#1
Gevorg Tepanosyan, Nairuhi Maghakyan, Lilit Sahakyan, Armen Saghatelyan
Children, the most vulnerable urban population group, are exceptionally sensitive to polluted environments, particularly urban soils, which can lead to adverse health effects upon exposure. In this study, the total concentrations of Ag, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Ti, V, and Zn were determined in 111 topsoil samples collected from kindergartens in Yerevan. The objectives of this study were to evaluate heavy metal pollution levels of kindergarten's soils in Yerevan, compare with national legal and international requirements on heavy metal contents in kindergarten soil, and assess related child health risk...
April 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28423485/m2-polarization-of-macrophages-facilitates-arsenic-induced-cell-transformation-of-lung-epithelial-cells
#2
Jiajun Cui, Wenhua Xu, Jian Chen, Hui Li, Lu Dai, Jacqueline A Frank, Shaojun Peng, Siying Wang, Gang Chen
The alterations in microenvironment upon chronic arsenic exposure may contribute to arsenic-induced lung carcinogenesis. Immune cells, such as macrophages, play an important role in mediating the microenvironment in the lungs. Macrophages carry out their functions after activation. There are two activation status for macrophages: classical (M1) or alternative (M2); the latter is associated with tumorigenesis. Our previous work showed that long-term arsenic exposure induces transformation of lung epithelial cells...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423108/-potential-health-risks-from-consumption-of-water-with-arsenic-in-colima-mexico
#3
Oliver Mendoza-Cano, Ramón Alberto Sánchez-Piña, Julián Barrón-Quintana, Herguin Benjamin Cuevas-Arellano, Pilar Escalante-Minakata, Ramón Solano-Barajas
Objective: To estimate potential health risks due to chronic ingestion of arsenic from groundwater in Colima, Mexico. Materials and methods: Samples were randomly taken in 36 wells from 10 local aquifers. Analysis was performed by ICP-OES following international standards. Geostatistical interpolation was performed with ArcGIS, implementing a model weighting inverse distance to estimate arsenic routes of exposure and consumption on each locality. The Hazard Quotient Ratio (HQ) and carcinogenic risk (R) for As were estimated...
January 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28420331/arsenic-treatment-increase-aurora-a-overexpression-through-e2f1-activation-in-bladder-cells
#4
Yu-Ting Kao, Chin-Han Wu, Shan-Ying Wu, Sheng-Hui Lan, Hsiao-Sheng Liu, Ya-Shih Tseng
BACKGROUND: Arsenic is a widely distributed metalloid compound that has biphasic effects on cultured cells. In large doses, arsenic can be toxic enough to trigger cell death. In smaller amounts, non-toxic doses may promote cell proliferation and induces carcinogenesis. Aberration of chromosome is frequently detected in epithelial cells and lymphocytes of individuals from arsenic contaminated areas. Overexpression of Aurora-A, a mitotic kinase, results in chromosomal instability and cell transformation...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28419900/dimethylarsenate-dma-exposure-influences-germination-rates-arsenic-uptake-and-arsenic-species-formation-in-wheat
#5
Elliott G Duncan, William A Maher, Simon D Foster, Frank Krikowa, Cathryn A O'Sullivan, Margaret M Roper
The contamination of cereals with arsenic (As) is a global health and agronomic concern. This study compared the physiological response, As uptake and As speciation in the grains and above ground tissues of 20 wheat cultivars exposed to 5 mg As kg(-1) soil as either arsenate (As(V)) or dimethylarsenate (DMA) under glasshouse conditions. Germination rates for the majority of cultivars exceeded 80% for the majority of cultivars when exposed to As(V), but fell significantly to 20-40% when exposed to DMA. For a number of cultivars, grain yields were 20-50% lower when plants were exposed to DMA compared to As(V)...
April 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28419250/enhanced-glycolysis-regulated-by-hif-1%C3%AE-via-mct-4-promotes-inflammation-in-arsenite-induced-carcinogenesis
#6
Fei Luo, Zhonglan Zou, Xinlu Liu, Min Ling, Qingling Wang, Qi Wang, Lu Lu, Le Shi, Yonglian Liu, Qizhan Liu, Aihua Zhang
Arsenite is well established as a human carcinogen, but the molecular mechanisms leading to arsenite-induced carcinogenesis are complex and elusive. Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with various biological phenomena. However, the role of glycolysis induced by arsenite is unknown. We have found that, with chronic exposure to arsenite, L-02 cells undergo a metabolic shift to glycolysis. In liver cells exposed to arsenite, hypoxia inducible factor-1α (HIF-1α) and monocarboxylate transporter-4 (MCT-4) are over-expressed...
April 17, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28418774/arsenic-in-the-groundwater-occurrence-toxicological-activities-and-remedies
#7
S K Jha, V K Mishra, T Damodaran, D K Sharma, Parveen Kumar
Arsenic (As) contamination in groundwater has become a geo-environmental as well as a toxicological problem across the globe affecting more than 100-million people in nearly 21 countries with its associated disease "arsenicosis." Arsenic poisoning may lead to fatal skin and internal cancers. In present review, an attempt has been made to generate awareness among the readers about various sources of occurrence of arsenic, its geochemistry and speciation, mobilization, metabolism, genotoxicity, and toxicological exposure on humans...
February 22, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28418431/body-burdens-sources-and-interrelations-of-selected-toxic-and-essential-elements-among-the-nine-cree-first-nations-of-eeyou-istchee-james-bay-region-of-northern-quebec-canada
#8
Evert Nieboer, Ian D Martin, Eric N Liberda, Eric Dewailly, Elizabeth Robinson, Leonard J S Tsuji
BACKGROUND: this article constitutes a report on the comprehensive Nituuchischaayihtitaau Aschii multi-community environment-and-health study conducted among the Cree peoples (Eeyouch) of northern Quebec, Canada. OBJECTIVES: to interpret observed concentrations of a suite of chemical elements in a multi-media biological monitoring study in terms of sources and predictors. METHODS: the concentrations of 5 essential and 6 toxic chemical elements were measured in whole blood, and/or in urine or hair by ICP-MS...
April 18, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28416360/primary-hepatic-angiosarcoma-and-liver-transplantation-radiological-surgical-histological-findings-and-clinical-outcome
#9
M Tran Minh, A Mazzola, F Perdigao, F Charlotte, G Rousseau, F Conti
Angiosarcoma is a rare type of soft tissue sarcoma that accounts for less than 1% of all sarcomas and only 2% of all primary hepatic tumours. Thorotrast, arsenic, and vinyl chloride monomer are frequently listed as occupational exposure risks. The estimated latency is long (10-40 years) in occupational cases and very long (60 years or more) in non-occupational cases. The symptoms and CT-scan appearance of hepatic angiosarcoma (HAS) are non-specific. We present a case of a 65-year-old Caucasian male with history of cryptogenic cirrhosis, low alpha-foetoprotein levels and a single, 4-cm nodule of potential atypical hepatocellular carcinoma (no washout at MRI and CT-scan) in segment VIII...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28414027/arsenic-activates-the-expression-of-3%C3%AE-hsd-in-mouse-leydig-cells-through-repression-of-histone-h3k9-methylation
#10
Ambreen Alamdar, Guochen Xi, Qingyu Huang, Meiping Tian, Syed Ali Musstjab Akber Shah Eqani, Heqing Shen
Arsenic exposure has been associated with male reproductive dysfunction by disrupting steroidogenesis; however, the roles of epigenetic drivers, especially histone methylation in arsenic-induced steroidogenic toxicity remain not well documented. In this study, we investigated the role of histone H3 lysine 9 (H3K9) methylation in steroidogenesis disturbance in mouse Leydig cells (MLTC-1) due to arsenic exposure. Our results indicated that mRNA and protein expression levels of 3β-hydroxysteroid dehydrogenase (3β-HSD) were both significantly up-regulated while the rest of key genes involved in steroidogenesis were down-regulated...
April 13, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28412307/the-9th-conference-on-metal-toxicity-and-carcinogenesis-the-conference-overview
#11
James T F Wise, Lei Wang, Zhuo Zhang, Xianglin Shi
Heavy metals, such as arsenic, chromium, cadmium, nickel, mercury, and uranium are known to cause many human diseases and health complications after occupational or environmental exposure. Consequently, metals are environmental health concerns. This manuscript is an overview of the 9th Conference on Metal Toxicity and Carcinogenesis held in October 2016 in Lexington, Kentucky. Since 2000, this biennial meeting brings together experts in the field to discuss current and prospective research in an effort to advance research pertaining to metal toxicity and carcinogenesis...
April 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28410574/comparison-of-different-cell-type-correction-methods-for-genome-scale-epigenetics-studies
#12
COMPARATIVE STUDY
Akhilesh Kaushal, Hongmei Zhang, Wilfried J J Karmaus, Meredith Ray, Mylin A Torres, Alicia K Smith, Shu-Li Wang
BACKGROUND: Whole blood is frequently utilized in genome-wide association studies of DNA methylation patterns in relation to environmental exposures or clinical outcomes. These associations can be confounded by cellular heterogeneity. Algorithms have been developed to measure or adjust for this heterogeneity, and some have been compared in the literature. However, with new methods available, it is unknown whether the findings will be consistent, if not which method(s) perform better. RESULTS: Methods: We compared eight cell-type correction methods including the method in the minfi R package, the method by Houseman et al...
April 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28410520/maternal-and-infant-inflammatory-markers-in-relation-to-prenatal-arsenic-exposure-in-a-u-s-pregnancy-cohort
#13
Shohreh F Farzan, Elizabeth B Brickley, Zhigang Li, Diane Gilbert-Diamond, Anala Gossai, Yu Chen, Caitlin G Howe, Thomas Palys, Margaret R Karagas
INTRODUCTION: Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. METHODS: We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood...
April 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28407582/influence-of-sample-matrix-on-the-bioavailability-of-arsenic-cadmium-and-lead-during-co-contaminant-exposure
#14
Cameron J Ollson, Euan Smith, Paul Herde, Albert L Juhasz
In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28399171/association-between-arsenic-exposure-and-soluble-thrombomodulin-a-cross-sectional-study-in-bangladesh
#15
M M Hasibuzzaman, Shakhawoat Hossain, Md Shofikul Islam, Atiqur Rahman, Adiba Anjum, Faruk Hossain, Nayan Chandra Mohanto, Md Rezaul Karim, Md Mominul Hoque, Zahangir Alam Saud, Hideki Miyataka, Seiichiro Himeno, Khaled Hossain
Chronic exposure to arsenic is associated with increased morbidity and mortality from cardiovascular disease (CVD); however, plausible biomarker for early prediction and the underlying mechanism of arsenic-related CVD have not yet been clearly understood. Endothelial dysfunction plays a central role in the development of CVD. We hypothesized that endothelial damage or dysfunction is an important aspect and may be an early event of arsenic-related CVD. Soluble thrombomodulin (sTM) in serum is thought to be a specific and stable marker for endothelial damage or dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28391263/salvianolic-acid-a-protects-h9c2-cells-from-arsenic-trioxide-induced-injury-via-inhibition-of-the-mapk-signaling-pathway
#16
Jing-Yi Zhang, Gui-Bo Sun, Yun Luo, Min Wang, Wei Wang, Yu-Yang Du, Ying-Li Yu, Xiao-Bo Sun
BACKGROUND/AIMS: This study aimed to investigate whether Salvianolic acid A (Sal A) conferred cardiac protection against Arsenic trioxide (ATO)-induced cardiotoxicity in H9c2 cells by inhibiting MAPK pathways activation. METHODS: H9c2 cardiac cells were exposed to 10 µM ATO for 24 h to induce cytotoxicity. The cells were pretreated with Sal A for 4 h before exposure to ATO. Cell viability was determined utilizing the MTT assay. The percentage of apoptosis was measured by a FITC-Annexin V/PI apoptosis kit for flow cytometry...
April 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28387569/associations-between-post-translational-histone-modifications-myelomeningocele-risk-environmental-arsenic-exposure-and-folate-deficiency-among-participants-in-a-case-control-study-in-bangladesh
#17
Jannah Tauheed, Marco Sanchez-Guerra, Jane J Lee, Ligi Paul, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Jacob Selhub, Robert O Wright, David C Christiani, Brent A Coull, Andrea A Baccarelli, Maitreyi Mazumdar
Arsenic exposure may contribute to disease risk in humans through alterations in the epigenome. Previous studies reported that arsenic exposure is associated with changes in plasma histone concentrations. Posttranslational histone modifications have been found to differ between the brain tissue of human embryos with neural tube defects and that of controls. Our objectives were to investigate the relationships between plasma histone 3 levels, history of having an infant with myelomeningocele, biomarkers of arsenic exposure, and maternal folate deficiency...
April 7, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28374919/all-trans-retinoic-acid-ameliorates-arsenic-induced-oxidative-stress-and-apoptosis-in-the-rat-uterus-by-modulating-mapk-signaling-proteins
#18
Aniruddha Chatterjee, Urmi Chatterji
Exposure to arsenic leads to inhibition of the antioxidant defense mechanism of the body. Reactive oxygen species generated in response to arsenic causes reproductive failures in exposed females and also acts as an inducer of apoptosis. As a prospective remedial agent, all-trans retinoic acid (ATRA) was assessed for reversing arsenic-induced oxidative stress and apoptosis. Rats exposed to arsenic for 28 days were allowed to recover naturally or were treated simultaneously with ATRA for 28 days or up to 56 days...
April 4, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28371690/a-protective-role-for-nitric-oxide-and-salicylic-acid-for-arsenite-phytotoxicity-in-rice-oryza-sativa-l
#19
Amit Pal Singh, Garima Dixit, Amit Kumar, Seema Mishra, Navin Kumar, Sameer Dixit, Pradyumna Kumar Singh, Sanjay Dwivedi, Prabodh Kumar Trivedi, Vivek Pandey, Om Prakash Dhankher, Gareth J Norton, Debasis Chakrabarty, Rudra Deo Tripathi
Nitric oxide (NO) and salicylic acid (SA) are important signaling molecules in plant system. In the present study both NO and SA showed a protective role against arsenite (As(III)) stress in rice plants when supplied exogenously. The application of NO and SA alleviated the negative impact of As(III) on plant growth. Nitric oxide supplementation to As(III) treated plants greatly decreased arsenic (As) accumulation in the roots as well as shoots/roots translocation factor. Arsenite exposure in plants decreased the endogenous levels of NO and SA...
February 24, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28366956/study-of-arsenic-exposure-in-oral-oropharyngeal-carcinoma-in-west-bengal
#20
Pritha Pal, Ranjan Raychowdhury, Tuphan Kanti Dolai, Sanchita Roy, Rinini Dastidar, Ajanta Halder
OBJECTIVES: To study any possible correlation between arsenic toxicity and the development of oral carcinoma in West Bengal population. MATERIAL AND METHODS: Ethical clearance for this study was obtained from the Vivekananda Institute of Medical Sciences. Out of 30 785 patients attending our hospital from November 2012 to July 2015, 107 cases and 50 control individuals were selected. The hair and buccal smear samples were obtained upon their consent for the purpose of the analysis of arsenic count and cytogenetic damage, respectively...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
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