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Arsenic exposure

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https://www.readbyqxmd.com/read/27918984/hypertension-among-adults-exposed-to-drinking-water-arsenic-in-northern-chile
#1
Emily M Hall, Johanna Acevedo, Francisca González López, Sandra Cortés, Catterina Ferreccio, Allan H Smith, Craig M Steinmaus
BACKGROUND: A growing number of studies have identified an association between exposure to inorganic arsenic and hypertension. However, results have not been consistent across studies. Additional studies are warranted, given the global prevalence of both arsenic exposure and morbidity attributable to hypertension. METHODS: We analyzed data collected from October 2007-December 2010 for a population-based cancer case-control study in northern Chile. Data included lifetime individual arsenic exposure estimates and information on potential confounders for a total of 1266 subjects...
December 2, 2016: Environmental Research
https://www.readbyqxmd.com/read/27915676/dietary-exposure-to-trace-elements-and-health-risk-assessment-in-the-region-of-valencia-spain-a-total-diet-study
#2
Silvia Marín, Olga Pardo, Rosario Báguena, Guillermina Font, Vicent Yusà
Dietary exposure of the Valencian Region population to lead, cadmium, inorganic arsenic (iAs), chromium, copper, tin and methylmercury (meHg) was assessed in a Total Diet Study carried out in the Region of Valencia in 2010-2011. A total of 8100 food samples were collected and analysed. Occurrence data were combined with consumption data to estimate dietary exposure in adults (>15 years of age) and young children (6-15 years of age). The estimated intake was calculated by a probabilistic approach. Average intake levels (optimistic scenario) for lead, inorganic arsenic (iAs), chromium and tin were 0...
December 5, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27914647/human-exposure-to-dietary-inorganic-arsenic-and-other-arsenic-species-state-of-knowledge-gaps-and-uncertainties
#3
Francesco Cubadda, Brian P Jackson, Kathryn L Cottingham, Yoshira Ornelas Van Horne, Margaret Kurzius-Spencer
Inorganic arsenic (iAs) is ubiquitous in the environment as arsenite (AsIII) and arsenate (AsV) compounds and biotransformation of these toxic chemicals leads to the extraordinary variety of organoarsenic species found in nature. Despite classification as a human carcinogen based on data from populations exposed through contaminated drinking water, only recently has a need for regulatory limits on iAs in food been recognized. The delay was due to the difficulty in risk assessment of dietary iAs, which critically relies on speciation analysis providing occurrence data for iAs in food - and not simply for total arsenic...
November 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27908426/environmental-exposures-of-trace-elements-assessed-using-keratinized-matrices-from-patients-with-chronic-kidney-diseases-of-uncertain-etiology-ckdu-in-sri-lanka
#4
Saranga Diyabalanage, Sanjeewani Fonseka, D M S N B Dasanayake, Rohana Chandrajith
An alarming increase in chronic kidney disease with unknown etiology (CKDu) has recently been reported in several provinces in Sri Lanka and chronic exposures to toxic trace elements were blamed for the etiology of this disease. Keratinized matrices such as hair and nails were investigated to determine the possible link between CKDu and toxic element exposures. Elements Li, B, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Hg and Pb of hair and nails of patients and age that matched healthy controls were determined with Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908416/suppression-of-the-brain-pituitary-testicular-axis-function-following-acute-arsenic-and-manganese-co-exposure-and-withdrawal-in-rats
#5
Isaac A Adedara, Amos O Abolaji, Ifeoluwa O Awogbindin, Ebenezer O Farombi
Despite the fact that most environmental exposures to metals do not occur in isolation, the combined effects of metal mixtures on brain-pituitary-gonadal axis are poorly known. The present study investigated the impacts of co-exposure to arsenic (As) and manganese (Mn) on sperm characteristics, reproductive hormones and selected oxidative stress indices in the brain, testes and epididymis of rats following exposure for 15 consecutive days to 60mg/L of AsO2Na and 30mg/L of MnCl2 in drinking water. The results showed that while the brain weight remained unaffected, the fluid intake and the weights of testes and epididymis significantly (p<0...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908234/sustained-early-disruption-of-mitochondrial-function-contributes-to-arsenic-induced-prostate-tumorigenesis
#6
B Singh, M Kulawiec, K M Owens, A Singh, K K Singh
Arsenic is a well-known human carcinogen that affects millions of people worldwide, but the underlying mechanisms of carcinogenesis are unclear. Several epidemiological studies have suggested increased prostate cancer incidence and mortality due to exposure to arsenic. Due to lack of an animal model of arsenic-induced carcinogenesis, we used a prostate epithelial cell culture model to identify a role for mitochondria in arsenic-induced prostate cancer. Mitochondrial morphology and membrane potential was impacted within a few hours of arsenic exposure of non-neoplastic prostate epithelial cells...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27901016/relationships-between-arsenic-concentrations-in-drinking-water-and-lung-and-bladder-cancer-incidence-in-u-s-counties
#7
William M Mendez, Sorina Eftim, Jonathan Cohen, Isaac Warren, John Cowden, Janice S Lee, Reeder Sams
Increased risks of lung and bladder cancer have been observed in populations exposed to high levels of inorganic arsenic. However, studies at lower exposures (i.e., less than 100 μg/l in water) have shown inconsistent results. We therefore conducted an ecological analysis of the association between historical drinking water arsenic concentrations and lung and bladder cancer incidence in U.S. counties. We used drinking water arsenic concentrations measured by the U.S. Geological Survey and state agencies in the 1980s and 1990s as proxies for historical exposures in counties where public groundwater systems and private wells are important sources of drinking water...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27895924/urinary-arsenic-species-concentration-in-residents-living-near-abandoned-metal-mines-in-south-korea
#8
Jin-Yong Chung, Byoung-Gwon Kim, Byung-Kook Lee, Jai-Dong Moon, Joon Sakong, Man Joong Jeon, Jung-Duck Park, Byung-Sun Choi, Nam-Soo Kim, Seung-Do Yu, Jung-Wook Seo, Byeong-Jin Ye, Hyoun-Ju Lim, Young-Seoub Hong
BACKGROUND: Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study were to analyze urinary arsenic species and their concentration in residents living near abandoned metal mines and to monitor the environmental health effects of abandoned metal mines in Korea. METHODS: This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27894683/biomonitoring-of-humans-exposed-to-arsenic-chromium-nickel-vanadium-and-complex-mixtures-of-metals-by-using-the-micronucleus-test-in-lymphocytes
#9
REVIEW
Balasubramanyam Annangi, Stefano Bonassi, Ricard Marcos, Alba Hernández
Various metals have demonstrated genotoxic and carcinogenic potential via different mechanisms. Until now, biomonitoring and epidemiological studies have been carried out to assess the genotoxic risk to exposed human populations. In this sense, the use of the micronucleus assay in peripheral blood lymphocytes has proven to be a useful tool to determine increased levels of DNA damage, as a surrogate biomarker of cancer risk. Here we review those biomonitoring studies focused on people exposed to arsenic, chromium, nickel, vanadium and complex mixtures of metals...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27891370/trace-elements-in-chronic-haemodialysis-patients-and-healthy-individuals-a-comparative-study
#10
Lokesh Shanmugam, Siva Ranganathan Green, Hemachandar Radhakrishnan, Tony Mathew Kadavanu, Arunkumar Ramachandrappa, Shashank Rakesh Tiwari, Amirtha Lakshmi Rajkumar, Ezhumalai Govindasamy
INTRODUCTION: End Stage Renal Disease (ESRD) patients despite receiving adequate Haemodialysis (HD) develop significant risk of Cardiovascular Disease (CVD). Abnormality in levels of trace elements may potentiate vascular injury by producing sustained inflammation and endothelial dysfunction. Hence, the present study was undertaken to evaluate the levels of trace elements in patients receiving HD. AIM: To study the blood levels of arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium among ESRD patients undergoing HD and compare it with healthy individuals...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889806/a-comparative-assessment-of-arsenic-risks-and-the-nutritional-benefits-of-fish-consumption-in-kuwait-arsenic-versus-omega-3-fatty-acids
#11
Adnan Husain, Kurunthachalam Kannan, Hing Man Chan, Brian Laird, Hanan Al-Amiri, Basma Dashti, Anwar Sultan, Amani Al-Othman, Bedraya Mandekar
Inorganic and organic forms of arsenic (As), as well as omega-3 fatty acids were measured in 578 fish/seafood samples that belong to 15 species of commonly consumed seafood in Kuwait. Arsenic speciation data, with the toxicological profile of inorganic arsenic (iAs) and fish consumption rates were applied in a probabilistic risk assessment to estimate the risk from exposure to iAs. The nutritional benefits of omega-3-fatty acid levels in various species of fish were taken into consideration. Results showed that the mean daily intake of iAs through fish consumption among the Kuwaiti population was 0...
November 26, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27889505/candesartan-ameliorates-arsenic-induced-hypertensive-vascular-remodeling-by-regularizing-angiotensin-ii-and-tgf-beta-signaling-in-rats
#12
Maibam Wanta Khuman, Sankaran Kutty Harikumar, Abdul Sadam, Manickam Kesavan, Vattaparambil Sukumaran Susanth, Subhashree Parida, Karam Pal Singh, Souvendra Nath Sarkar
Arsenic exposure can cause several cardiovascular diseases, including hypertension, atherosclerosis and microvascular disease. Earlier, we reported that arsenic-mediated enhancement of angiotensin II (AngII) signaling can impair vascular physiology. Here, we investigated whether the AT1 receptor (AT1R) blocker candesartan can ameliorate the arsenic-induced hypertensive vascular remodeling in rats and whether the amelioration could relate to attenuation in vascular AngII and TGF-β signaling. Rats were exposed to sodium arsenite (50ppm) through drinking water for 90 consecutive days...
November 23, 2016: Toxicology
https://www.readbyqxmd.com/read/27886791/environmental-exposures-and-cardiovascular-disease-a-challenge-for-health-and-development-in-low-and-middle-income-countries
#13
REVIEW
Melissa S Burroughs Peña, Allman Rollins
Environmental exposures in low- and middle-income countries lie at the intersection of increased economic development and the rising public health burden of cardiovascular disease. Increasing evidence suggests an association of exposure to ambient air pollution, household air pollution from biomass fuel, lead, arsenic, and cadmium with multiple cardiovascular disease outcomes, including hypertension, coronary heart disease, stroke, and cardiovascular mortality. Although populations in low- and middle-income countries are disproportionately exposed to environmental pollution, evidence linking these exposures to cardiovascular disease is derived from populations in high-income countries...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27880879/arsenic-levels-among-pregnant-women-and-newborns-in-canada-results-from-the-maternal-infant-research-on-environmental-chemicals-mirec-cohort
#14
Adrienne S Ettinger, Tye E Arbuckle, Mandy Fisher, Chun Lei Liang, Karelyn Davis, Ciprian-Mihai Cirtiu, Patrick Bélanger, Alain LeBlanc, William D Fraser
Arsenic is a common environmental contaminant from both naturally-occurring and anthropomorphic sources and human exposure can be detected in various tissues. Its toxicity depends on many factors including the chemical form, valence state, bioavailability, metabolism and detoxification within the human body. Of paramount concern, particularly with respect to health effects in children, is the timing of exposure as the prenatal and early life periods are more susceptible to toxic effects. The Maternal-Infant Research on Environmental Chemicals (MIREC) cohort was established to obtain national-level biomonitoring data for approximately 2,000 pregnant women and their infants between 2008 and 2011 from 10 Canadian cities...
November 20, 2016: Environmental Research
https://www.readbyqxmd.com/read/27876813/oncogenic-transformation-of-human-lung-bronchial-epithelial-cells-induced-by-arsenic-involves-ros-dependent-activation-of-stat3-mir-21-pdcd4-mechanism
#15
Poyil Pratheeshkumar, Young-Ok Son, Sasidharan Padmaja Divya, Lei Wang, Zhuo Zhang, Xianglin Shi
Arsenic is a well-documented human carcinogen. The present study explored the role of the onco-miR, miR-21 and its target protein, programmed cell death 4 (PDCD4) in arsenic induced malignant cell transformation and tumorigenesis. Our results showed that treatment of human bronchial epithelial (BEAS-2B) cells with arsenic induces ROS through p47(phox), one of the NOX subunits that is the key source of arsenic-induced ROS. Arsenic exposure induced an upregulation of miR-21 expression associated with inhibition of PDCD4, and caused malignant cell transformation and tumorigenesis of BEAS-2B cells...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871140/metabolic-response-of-agrobacterium-tumefaciens-5a-to-arsenite
#16
Monika Tokmina-Lukaszewska, Zunji Shi, Brian Tripet, Timothy R McDermott, Valérie Copié, Brian Bothner, Gejiao Wang
Wide-spread abundance in soil and water, coupled with high toxicity have put arsenic at the top of the list of environmental contaminants. Early studies demonstrated that both concentration and the valence state of inorganic arsenic (arsenite, As(III) vs. arsenate As(V)) can be modulated by microbes. Using genetics, transcriptomic and proteomic techniques, microbe-arsenic detoxification, respiratory As(V) reduction, and As(III) oxidation have since been examined. The effect of arsenic exposure on whole-cell intracellular microbial metabolism, however, has not been extensively studied...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27866735/metal-exposures-from-aluminum-cookware-an-unrecognized-public-health-risk-in-developing-countries
#17
Jeffrey D Weidenhamer, Meghann P Fitzpatrick, Alison M Biro, Peter A Kobunski, Michael R Hudson, Rebecca W Corbin, Perry Gottesfeld
Removing lead from gasoline has resulted in decreases in blood lead levels in most of the world, but blood lead levels remain elevated in low and middle-income countries compared to more developed countries. Several reasons for this difference have been investigated, but few studies have examined the potential contribution from locally-made aluminum cookware. In a previous study of cookware from a single African country, Cameroon, artisanal aluminum cookware that is made from scrap metal released significant quantities of lead...
November 17, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27865606/arsenic-contamination-in-agricultural-soils-of-bengal-deltaic-region-of-west-bengal-and-its-higher-assimilation-in-monsoon-rice
#18
Anamika Shrivastava, Anil Barla, Surjit Singh, Shivanand Mandraha, Sutapa Bose
In the Bengal deltaic region, the shallow groundwater laced with arsenic is used for irrigation frequently and has elevated the soil arsenic in agricultural soil. However, the areas with seasonal flooding reduce arsenic in top layers of the soils. Study shows arsenic accumulation in the deeper soil layers with time in the contaminated agricultural soil (19.40±0.38mg/kg in 0-5cm, 27.17±0.44mg/kg in 5-10cm and 41.24±0.48mg/kg in 10-15cm) in 2013 whereas depletion in 2014 and its buildup in different parts of monsoon rice plant in Nadia, India...
November 9, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27862296/dna-methylation-changes-in-mexican-children-exposed-to-arsenic-from-two-historic-mining-areas-in-san-luis-potos%C3%A3
#19
Jorge Alejandro Alegría-Torres, Leticia Carrizales-Yánez, Fernando Díaz-Barriga, Fernando Rosso-Camacho, Valeria Motta, Letizia Tarantini, Valentina Bollati
Arsenic is a carcinogen and epimutagen that threatens the health of exposed populations worldwide. In this study, we examined the methylation status of Alu and long interspersed nucleotide elements (LINE-1) and their association with levels of urinary arsenic in 84 Mexican children between 6 and 12 years old from two historic mining areas in the State of San Luis Potosí, Mexico. Urinary arsenic levels were determined by atomic absorption spectrophotometry and DNA methylation analysis was performed in peripheral blood leukocytes by bisulfite-pyrosequencing...
December 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27859561/chronic-toxicity-of-arsenic-during-rhinella-arenarum-embryonic-and-larval-development-potential-biomarkers-of-oxidative-stress-and-antioxidant-response
#20
Mariana Noelia Mardirosian, Cecilia Inés Lascano, Guillermina Azucena Bongiovanni, Andrés Venturino
The Argentinean autochthonous toad Rhinella arenarum was selected to study the chronic toxicity of arsenic and the biochemical responses elicited by exposure to As in water during embryonic and larval development. A significant decrease in the total reactive antioxidant potential and in catalase activity was observed in individuals exposed chronically to sublethal concentrations of As, which is indicative of an oxidative stress situation. However, an antioxidant response was elicited during chronic exposure to As, as evidenced by the increase in endogenous reduced glutathione content and glutathione-related enzymatic activities such as glutathione -S-transferase and reductase...
November 18, 2016: Environmental Toxicology and Chemistry
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