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Al Amyloidosis

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https://www.readbyqxmd.com/read/28439985/the-utility-of-mass-fix-to-detect-and-monitor-monoclonal-proteins-in-the-clinic
#1
Paolo Milani, David L Murray, David R Barnidge, Mindy C Kohlhagen, John R Mills, Giampaolo Merlini, Surendra Dasari, Angela Dispenzieri
The detection and quantification of monoclonal-proteins (M-proteins) are necessary for the diagnosis and evaluation of response in plasma cell dyscrasias. Immunoglobulin enrichment-coupled with matrix-assisted laser desorption ionization time-of-flight mass-spectrometry (MASS-FIX) is a simple and inexpensive method to identify M-proteins, but its clinical generalizability has not yet been elucidated. We compared MASS-FIX to protein electrophoresis (PEL), serum/urine immunofixation-electrophoresis (IFE) and quantitative serum free-light chain (FLC) for the identification of M-proteins in different clinical diagnoses...
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439924/prevalence-and-predictors-of-thyroid-functional-abnormalities-in-newly-diagnosed-al-amyloidosis
#2
E Muchtar, D S Dean, A Dispenzieri, D Dingli, F K Buadi, M Q Lacy, S R Hayman, P Kapoor, N Leung, S Russell, J A Lust, Yi Lin, R Warsame, W Gonsalves, T V Kourelis, R S Go, R Chakraborty, S Zeldenrust, R A Kyle, S Vincent Rajkumar, S K Kumar, M A Gertz
BACKGROUND: Data on the effect of systemic immunoglobulin light chain amyloidosis (AL amyloidosis) on thyroid function are limited. OBJECTIVE: To assess the prevalence of hypothyroidism in AL amyloidosis patients and determine its predictors. METHODS: 1142 newly diagnosed AL amyloidosis patients were grouped based on the thyroid-stimulating hormone (TSH) measurement at diagnosis: hypothyroid group (TSH above upper normal reference; >5 mIU L(-1) ; n = 217, 19% of study participants) and euthyroid group (n = 925, 81%)...
April 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28437006/prognosis-and-risk-assessment-in-al-amyloidosis-there-and-back-again
#3
EDITORIAL
Efstathios Kastritis, Meletios A Dimopoulos
No abstract text is available yet for this article.
May 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28434927/impact-of-autologous-stem-cell-transplantation-on-the-incidence-and-outcome-of-oligoclonal-bands-in-patients-with-light-chain-amyloidosis
#4
Luis Gerardo Rodríguez-Lobato, Carlos Fernández de Larrea, M Teresa Cibeira, Natalia Tovar, Juan I Aróstegui, Laura Rosiñol, Tania Díaz, Ester Lozano, Montserrat Elena, Jordi Yagüe, Joan Bladé
The emergence of oligoclonal bands (OB) in patients with multiple myeloma achieving a complete remission (CR) after autologous stem cell transplantation (ASCT) and the use of novel agents is a well-recognized event. The presence of OB is associated with favorable outcome. However, the emergence of OB in light-chain (AL) amyloidosis has never been investigated. The aim of the study was to determine the incidence, natural history and prognostic impact of OB in 50 patients with AL amyloidosis who achieved at least a partial response (PR) either after up-front ASCT (20 patients [40%]) or after conventional treatment in patients ineligible for transplant (30 patients [60%])...
April 18, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28434371/immunoparesis-in-newly-diagnosed-al-amyloidosis-is-a-marker-for-response-and-survival
#5
Eli Muchtar, Angela Dispenzieri, Shaji K Kumar, Francis K Buadi, Martha Q Lacy, Steven Zeldenrust, Suzanne R Hayman, Nelson Leung, Taxiarchis V Kourelis, Wilson Gonsalves, Rajshekhar Chakraborty, Steven Russell, David Dingli, John A Lust, Yi Lin, Prashant Kapoor, Ronald Go, Robert A Kyle, S Vincent Rajkumar, Morie A Gertz
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434368/outcome-of-very-young-%C3%A2-40-years-patients-with-immunoglobulin-light-chain-al-amyloidosis
#6
Jithma P Abeykoon, Jonas Paludo, Angela Dispenzieri, Morie A Gertz, David Dingli, Francis K Baudi, Wilson I Gonsalves, Robert A Kyle, Martha Q Lacy, Suzanne R Hayman, Nelson Leung, Taxiarchis Kourelis, S Vincent Rajkumar, Shaji Kumar, Prashant Kapoor
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434348/six-minute-walk-test-6mwt-in-al-amyloidosis-baseline-and-12-month-follow-up-after-chemotherapy
#7
Katarina Flatman, Darren Foard, Eleanor Pyart, Gaik Hughes, Randolph Gaudia, Charlene Kearney, Ismail Elmi, Alica Bangova, Pamela Libo-On, Joan Caringal-Galima, Emma Rowles, Christianne Guillotte, Philip Hawkins, Julian Gillmore, Thirusha Lane
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434347/interim-analysis-of-the-phase-1a-b-study-of-chimeric-fibril-reactive-monoclonal-antibody-11-1f4-in-patients-with-al-amyloidosis
#8
Camille V Edwards, Julia Gould, Arielle L Langer, Markus Mapara, Jai Radhakrishnan, Mathew S Maurer, Shahzad Raza, John G Mears, Jonathan Wall, Alan Solomon, Suzanne Lentzsch
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434343/patients-with-al-amyloidosis-and-low-free-light-chain-burden-have-distinct-clinical-features-and-outcome
#9
Paolo Milani, Marco Basset, Francesca Russo, Andrea Foli, Francesca Lavatelli, Mario Nuvolone, Giovanni Ferraro, Giovanni Palladini, Giampaolo Merlini
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434342/patterns-of-relapse-after-upfront-bortezomib-therapy-in-al-amyloidosis
#10
Marco Basset, Paolo Milani, Francesca Russo, Francesca Lavatelli, Mario Nuvolone, Andrea Foli, Stefano Perlini, Giovanni Palladini, Giampaolo Merlini
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434330/significant-association-between-renal-function-and-area-of-amyloid-deposition-evident-in-kidney-biopsy-specimens-in-both-aa-and-al-amyloidosis
#11
Takeshi Kuroda, Yumi Ito, Naofumi Imai, Yukiko Nozawa, Hiroe Sato, Takeshi Nakatsue, Yoko Wada, Mitsuhiro Ueno, Masaaki Nakano, Ichiei Narita
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434326/urinary-albumin-to-creatinine-ratio-in-diagnosis-and-risk-stratification-of-renal-al-amyloidosis
#12
Giovanni Palladini, Paolo Milani, Marco Basset, Francesca Russo, Francesca Lavatelli, Mario Nuvolone, Giovanni Ferraro, Margherita Bozzola, Andrea Foli, Giampaolo Merlini
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434323/identification-and-quantification-of-urinary-monoclonal-proteins-by-capillary-electrophoresis-in-al-amyloidosis
#13
Francesca Russo, Veronica Valentini, Marco Basset, Tiziana Bosoni, Paolo Milani, Giovanni Ferraro, Laura Pirolini, Andrea Foli, Francesca Lavatelli, Fabrizio Belvisi, Giorgio Consogno, Mario Nuvolone, Filomena Li Bergolis, Margherita Bozzola, Riccardo Albertini, Giovanni Palladini, Giampaolo Merlini
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434320/a-good-clonal-response-to-chemotherapy-in-al-amyloidosis-is-associated-with-improved-quality-of-life-and-function-at-1-year
#14
John-Paul Carter, Darren Foard, Lisa Rannigan, Kamela Aliaz, Shameem Mahmood, Sajitha Sachchithanantham, Marianna Fontana, Cristina Quarta, Ana Martinez De Azcona Naharro, Taryn Youngstein, Tamer Rezk, Ashutosh Wechalekar, Carol Whelan, Helen Lachmann, Philip Hawkins, Julian Gillmore, Thirusha Lane
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434310/diagnostic-accuracy-of-new-indirect-elisas-for-free-light-chain-quantification-in-fat-tissue-of-patients-with-al-amyloidosis
#15
Elisabeth Eelsing, Johan Bijzet, Bouke Hazenberg
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434306/myocardial-uptake-of-99m-tc-dpd-in-patients-with-al-amyloidosis
#16
Carlos de Miguel, Laura Llorente, Francisco Javier de Haro-Del Moral, Pablo García-Pavía, Esther González-López, Javier Segovia, Isabel Krsnik
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434304/immunoparesis-status-in-al-amyloidosis-at-diagnosis-affects-response-and-survival-by-regimen-type
#17
Eli Muchtar, Angela Dispenzieri, Shaji K Kumar, Francis K Buadi, Martha Q Lacy, Steven Zeldenrust, Suzanne R Hayman, Nelson Leung, Rajshekhar Chakraborty, Steven Russell, David Dingli, John A Lust, Yi Lin, Prashant Kapoor, Ronald Go, Robert A Kyle, Vincent S Rajkumar, Morie A Gertz
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434298/response-to-bendamustine-is-associated-with-a-survival-advantage-in-a-heavily-pretreated-patients-with-al-amyloidosis
#18
Paolo Milani, Stefan Schönland, Giovanni Palladini, Christoph Kimmich, Marco Basset, Francesca Russo, Andrea Foli, Stefano Perlini, Tilmann Bochtler, Anthony D Ho, Giampaolo Merlini, Ute Hegenbart
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434293/severity-and-reversibility-of-cardiac-dysfunction-and-residual-concentration-of-amyloidogenic-light-chain-predict-overall-survival-of-patients-with-al-amyloidosis-who-attain-complete-response
#19
Giovanni Palladini, Paolo Milani, Marco Basset, Francesca Russo, Francesca Lavatelli, Mario Nuvolone, Giovanni Ferraro, Margherita Bozzola, Andrea Foli, Stefano Perlini, Giampaolo Merlini
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434267/amyloid-in-bone-marrow-smears-in-systemic-light-chain-amyloidosis
#20
Christoph Kimmich, Stefan Schönland, Sandra Kräker, Mindaugas Andrulis, Anthony D Ho, Gudrun Mayer, Tobias Dittrich, Michael Hundemer, Ute Hegenbart
We performed a prospective sensitivity analysis to detect amyloid in bone marrow (BM) smears stained with Congo red (CR) and according to Pappenheim of patients with systemic light-chain (AL) amyloidosis. Results were directly compared to routine BM histology and fat aspiration. We analysed 198 BM smears from patients with the diagnosis or suspicion of systemic AL amyloidosis. Ultimately, the diagnosis could be established for 168 patients. Amyloid was detected on BM smears with CR in 33% (56/168). All patients suspicious for amyloid on Pappenheim staining (n = 39) showed substantial amyloid infiltration on CR...
April 23, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
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