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https://www.readbyqxmd.com/read/27906487/neutrophil-activation-during-acute-human-anaphylaxis-analysis-of-mpo-and-scd62l
#1
Abbie Francis, Erika Bosio, Shelley F Stone, Daniel M Fatovich, Glenn Arendts, Yusuf Nagree, Stephen P J Macdonald, Hugh Mitenko, Mani Rajee, Sally Burrows, Simon G A Brown
BACKGROUND: The mechanisms involved in the amplification of the mast cell response during anaphylaxis are unclear. Mouse models of anaphylaxis demonstrate the critical involvement of neutrophils. These innate immune cells are highly abundant in peripheral blood and can be rapidly activated to trigger both local and systemic inflammation. OBJECTIVE: To investigate neutrophil activation in peripheral blood during acute human anaphylaxis. METHODS: Patients presenting to the Emergency Department with anaphylaxis underwent blood sampling upon enrolment and at up to three subsequent time points...
December 1, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27906466/duodenitis-proximal-jejunitis-in-horses-after-experimental-administration-of-clostridium-difficile-toxins
#2
L G Arroyo, M C Costa, B B Guest, B L Plattner, B N Lillie, J S Weese
BACKGROUND: Duodenitis-proximal jejunitis (DPJ) is an acute sporadic gastrointestinal disorder of horses of unknown cause. HYPOTHESIS/OBJECTIVES: We hypothesize that Clostridium difficile toxins are involved in the pathogenesis of DPJ in horses. The objective of this study was to determine whether experimentally delivered C. difficile toxins cause clinical signs and histologic lesions similar to those of naturally occurring DPJ. ANIMALS: Six healthy mature mixed breed horses...
December 1, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27906382/laser-patterned-functionalized-cvd-graphene-as-highly-transparent-conductive-electrodes-for-polymer-solar-cells
#3
Luca La Notte, Enrica Villari, Alessandro Lorenzo Palma, Alberto Sacchetti, Maria Michela Giangregorio, Giovanni Bruno, Aldo Di Carlo, Giuseppe Valerio Bianco, Andrea Reale
A five-layer (5L) graphene on a glass substrate has been demonstrated as a transparent conductive electrode to replace indium tin oxide (ITO) in organic photovoltaic devices. The required low sheet resistance, while maintaining high transparency, and the need of a wettable surface are the main issues. To overcome these, two strategies have been applied: (i) the p-doping of the multilayer graphene, thus reaching 25 Ω □(-1) or (ii) the O2-plasma oxidation of the last layer of the 5L graphene that results in a contact angle of 58° and a sheet resistance of 134 Ω □(-1)...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906144/positive-regulation-of-biochemical-parameters-by-tea-polyphenol-encapsulated-solid-lipid-nanoparticles-at-in-vitro-and-in-vivo-conditions
#4
Karikalan Kulandaivelu, Abul Kalam Azad Mandal
Tea polyphenols (TPPs) comprise preventive and therapeutic potentials against cancer, cardiovascular and neurological disorders. Chemical instability of TPP which leads to low bioavailability is the major constrain to its use as therapeutic agent. The authors prepared TPP encapsulated solid lipid nanoparticles (TPP-SLNs) to increase its stability and bioefficacy. Comparison of Fourier transformed infrared spectra of unloaded SLN, free TPP and TPP-SLN indicated encapsulation of TPP. Sustained release of TPP from TP-SLN was observed...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27906127/malaria-parasite-celtos-targets-the-inner-leaflet-of-cell-membranes-for-pore-dependent-disruption
#5
John R Jimah, Nichole D Salinas, Monica Sala-Rabanal, Nathaniel G Jones, L David Sibley, Colin G Nichols, Paul H Schlesinger, Niraj H Tolia
Apicomplexan parasites contain a conserved protein CelTOS that, in malaria parasites, is essential for traversal of cells within the mammalian host and arthropod vector. However, the molecular role of CelTOS is unknown because it lacks sequence similarity to proteins of known function. Here, we determined the crystal structure of CelTOS and discovered CelTOS resembles proteins that bind to and disrupt membranes. In contrast to known membrane disruptors, CelTOS has a distinct architecture, specifically binds phosphatidic acid commonly present within the inner leaflet of plasma membranes, and potently disrupts liposomes composed of phosphatidic acid by forming pores...
December 1, 2016: ELife
https://www.readbyqxmd.com/read/27906058/vascular-endothelial-growth-factor-levels-and-rheumatic-diseases-of-the-elderly
#6
Perrine Smets, Valérie Devauchelle-Pensec, Paul-Olivier Rouzaire, Bruno Pereira, Marc Andre, Martin Soubrier
BACKGROUND: Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether elevated VEGF is specific for a rheumatic disease, the inflammation or edema that occurs with these pathological conditions...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27905999/factors-associated-with-hiv-viral-load-blips-and-the-relationship-between-self-reported-adherence-and-efavirenz-blood-levels-on-blip-occurrence-a-case-control-study
#7
Aaron Farmer, Xun Wang, Anuradha Ganesan, Robert G Deiss, Brian K Agan, Thomas A O'Bryan, Kevin Akers, Jason F Okulicz
BACKGROUND: The uncertain etiology of HIV viral load (VL) blips may lead to increased use of clinical resources. We evaluated the association of self-reported adherence (SRA) and antiretroviral (ART) drug levels on blip occurrence in US Military HIV Natural History Study (NHS) participants who initiated the single-tablet regimen efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF). METHODS: ART-naïve NHS participants started on EFV/FTC/TDF between 2006 and 2013 who achieved VL suppression (<50 copies/mL) within 12 months and had available SRA and stored plasma samples were included...
March 22, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905556/cellular-aspartyl-proteases-promote-the-unconventional-secretion-of-biologically-active-hiv-1-matrix-protein-p17
#8
Francesca Caccuri, Maria Luisa Iaria, Federica Campilongo, Kristen Varney, Alessandro Rossi, Stefania Mitola, Silvia Schiarea, Antonella Bugatti, Pietro Mazzuca, Cinzia Giagulli, Simona Fiorentini, Wuyuan Lu, Mario Salmona, Arnaldo Caruso
The human immune deficiency virus type 1 (HIV-1) matrix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detected in blood and in different organs and tissues even in HIV-1-infected patients undergoing successful combined antiretroviral therapy (cART). Extracellularly, p17 deregulates the function of different cells involved in AIDS pathogenesis. The mechanism of p17 secretion, particularly during HIV-1 latency, still remains to be elucidated. A recent study showed that HIV-1-infected cells can produce Gag without spreading infection in a model of viral latency...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905554/increased-plasma-vegf-levels-following-ischemic-preconditioning-are-associated-with-downregulation-of-mirna-762-and-mir-3072-5p
#9
Koji Ueno, Makoto Samura, Tamami Nakamura, Yuya Tanaka, Yuriko Takeuchi, Daichi Kawamura, Masaya Takahashi, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated the associated mechanisms after performing remote IPC (rIPC) of lower limbs by clamping abdominal aorta in mice. Subsequent experiments showed decreased damage and paralysis of lower limbs following spinal cord injury (SCI). Concomitantly, plasma vascular endothelial growth factor (VEGF) levels were increased 24 h after rIPC compared with those in sham-operated animals. In subsequent microRNA analyses, thirteen microRNAs were downregulated in exosomes 24 h after rIPC...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905409/compound-danshen-dripping-pills-modulate-the-perturbed-energy-metabolism-in-a-rat-model-of-acute-myocardial-ischemia
#10
Jiahua Guo, Yonghong Yong, Jiye Aa, Bei Cao, Runbin Sun, Xiaoyi Yu, Jingqiu Huang, Na Yang, Lulu Yan, Xinxin Li, Jing Cao, Nan Aa, Zhijian Yang, Xiangqing Kong, Liansheng Wang, Xuanxuan Zhu, Xiaohui Ma, Zhixin Guo, Shuiping Zhou, He Sun, Guangji Wang
The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in a rat model of acute myocardial ischemia induced by isoproterenol (ISO) and administrated with CDDP using a metabolomics platform. Our data revealed that the ISO-induced animal model showed obvious myocardial injury, decreased energy production, and a marked change in metabolomic patterns in plasma and heart tissue...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905403/infusion-with-human-bone-marrow-derived-mesenchymal-stem-cells-improves-%C3%AE-cell-function-in-patients-and-non-obese-mice-with-severe-diabetes
#11
Lirong Li, Hui Hui, Xiaolei Jia, Jie Zhang, Ying Liu, Qianyue Xu, Dalong Zhu
Mesenchymal stem cells (MSCs) transplantation is a promising therapeutic strategy for type 1 diabetes (T1D). However, little is known on whether MSC transplantation can benefit T1D patients with ketoacidosis and its potential actions. Here, we show that infusion with bone marrow MSCs preserves β-cell function in some T1D patients with ketoacidosis by decreasing exogenous insulin requirement and increasing plasma C-peptide levels up to 1-2 years. MSC transplantation increased plasma and islet insulin contents in non-obese diabetic (NOD) mice with severe diabetes...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904878/de-novo-pyrimidine-biosynthesis-connects-cell-integrity-to-amphotericin-b-susceptibility-in-cryptococcus-neoformans
#12
Dithi Banerjee, Timothy C Umland, John C Panepinto
The use of amphotericin B (AmB) in conjunction with 5-fluorocytosine (5-FC) is known to be the optimal therapy for treating cryptococcosis, but the mechanism by which 5-FC synergizes with AmB is unknown. In this study, we generated a Cryptococcus neoformans ura1Δ mutant lacking dihydroorotate dehydrogenase (DHODH), which demonstrated temperature-sensitive growth due to a defect in cell integrity and sensitivity to cell wall-damaging agents. In addition, sensitivity to AmB was greatly increased. Inclusion of uracil or uridine in the medium did not suppress the cell wall or AmB phenotype, whereas complementation with the wild-type URA1 gene complemented the mutant phenotype...
November 2016: MSphere
https://www.readbyqxmd.com/read/27904760/serum-glycoprotein-derived-n-and-o-linked-glycans-as-cancer-biomarkers
#13
REVIEW
Ying Lan, Cui Hao, Xuan Zeng, Yanli He, Pengjiao Zeng, Zhihua Guo, Lijuan Zhang
Early detection of cancer is the key to improving survival. Since most clinically used serum cancer biomarkers are either glycoproteins or glycan structures that can be recognized by specific monoclonal antibodies, developing glycan structure-based biomarkers from human serum/plasma glycoproteins through mass spectrometry (MS) analysis are active research field during the past decades. Numerous studies have shown that changes in serum/plasma glycan structures occur during cancer initiation, progression, and treatment...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27904735/urinary-metabolomics-of-young-italian-autistic-children-supports-abnormal-tryptophan-and-purine-metabolism
#14
Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico
BACKGROUND: Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines and plasma of ASD and control individuals, suggested that autistic patients may share some metabolic abnormalities, despite several inconsistencies stemming from differences in technology, ethnicity, age range, and definition of "control" status...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27904654/augmentation-of-histone-deacetylase-3-hdac3-epigenetic-signature-at-the-interface-of-proinflammation-and-insulin-resistance-in-patients-with-type-2-diabetes
#15
Chandrakumar Sathishkumar, Paramasivam Prabu, Mahalingam Balakumar, Raji Lenin, Durai Prabhu, Ranjith Mohan Anjana, Viswanathan Mohan, Muthuswamy Balasubramanyam
BACKGROUND: A role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes in histone deacetylase (HDAC) are emerging as novel epigenetic biomarkers, there is lack of studies to demonstrate their clinical relevance in diabetes. Therefore, we investigated the extent of HDAC machinery and inflammatory signals in peripheral blood mononuclear cells (PBMCs) from patients with type 2 diabetes mellitus (T2DM) compared to control subjects...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27904554/effect-of-helicobacter-pylori-eradication-on-insulin-resistance-among-prediabetic-patients-a-pilot-study-and-single-blind-randomized-controlled-clinical-trial
#16
Ali Kachuei, Masoud Amini, Vahid Sebghatollahi, Awat Feizi, Pooria Hamedani, Bijan Iraj
BACKGROUND: Type II diabetes mellitus (T2DM) is the prevalent type of diabetes in the world. Prediabetic patients are the most probable group to get diabetes. Several studies have mentioned the role of inflammation in the incidence of diabetes. The origin of inflammation can be infection such as Helicobacter pylori (HP) infection. This study was designed to explore the effect of HP eradication on insulin resistance. MATERIALS AND METHODS: This single-blind randomized controlled clinical trial was conducted in 2014-2015...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904510/correlation-between-plasma-angiopoietin-1-angiopoietin-2-and-matrix-metalloproteinase-2-in-coronary-heart-disease
#17
Haoyu Wu, Xiling Shou, Lei Liang, Congxia Wang, Xiaowei Yao, Gong Cheng
INTRODUCTION: Angiopoietin-2 (Ang-2) plays a critical role in inducing tumor cell infiltration, and this invasive phenotype is caused by up-regulation of matrix metalloproteinase (MMP)-2. The relationship between Ang-2 and MMP-2 in atherosclerosis has not been reported yet. The aim is to measure the plasma concentrations of Ang-1, Ang-2 and MMP-2 and assess the correlation between the concentrations of these factors in coronary heart disease (CHD) patients. MATERIAL AND METHODS: The testing was done in a cross-sectional study...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904271/histologic-evidence-of-new-collagen-formulation-using-platelet-rich-plasma-in-skin-rejuvenation-a-prospective-controlled-clinical-study
#18
Ozlem Karabudak Abuaf, Hamza Yildiz, Hüseyin Baloglu, Memet Ersan Bilgili, Hasan Aktug Simsek, Bilal Dogan
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. METHODS: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904188/cutaneous-manifestations-of-multiple-myeloma
#19
Binodini Behera, Monali Pattnaik, Bharti Sahu, Prasenjeet Mohanty, Swapna Jena, Liza Mohapatra
Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. We report four such interesting patients who presented to us initially with common dermatoses such as leukocytoclastic vasculitis, pyoderma gangrenosum, and vesiculobullous disorders and were subsequently diagnosed to have MM. There were no skeletal involvements or renal function abnormality at the time of presentation...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27903985/the-tissue-inhibitor-of-metalloproteinases-1-timp-1-promotes-survival-and-migration-of-acute-myeloid-leukemia-cells-through-cd63-pi3k-akt-p21-signaling
#20
Dorian Forte, Valentina Salvestrini, Giulia Corradi, Lara Rossi, Lucia Catani, Roberto M Lemoli, Michele Cavo, Antonio Curti
We and others have shown that the Tissue Inhibitor of Metalloproteinases-1 (TIMP-1), a member of the inflammatory network exerting pleiotropic effects in the bone marrow (BM) microenvironment, regulates the survival and proliferation of different cell types, including normal hematopoietic progenitor cells. Moreover, TIMP-1 has been shown to be involved in cancer progression. However, its role in leukemic microenvironment has not been addressed. Here, we investigated the activity of TIMP-1 on Acute Myelogenous Leukemia (AML) cell functions...
November 26, 2016: Oncotarget
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