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Periodontics

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https://www.readbyqxmd.com/read/28544936/effect-of-follicular-dendritic-cell-secreted-protein-on-gene-expression-of-human-periodontal-ligament-cells
#1
Lin Xiang, Na Xin, Ying Yuan, Xiaogang Hou, Junwei Chen, Na Wei, Ping Gong
OBJECTIVE: The objective of this study was to investigate the specific roles of follicular dendritic cell secreted protein (FDC-SP), a protein exists in saliva, in the inhibition of calcium precipitation during periodontal regeneration, as well as affect phenotype expression of human periodontal ligament cells (hPDLCs) during the differentiation process. DESIGN: To investigate this, we applied microarray technology to identify gene expression changes in hPDLCs transfected with FDC-SP and then clustered them according to their biological functions...
May 17, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28544606/effects-of-tooth-storage-media-on-periodontal-ligament-preservation
#2
Md Riasat Hasan, Hiroaki Takebe, Nazmus Shalehin, Nobuko Obara, Takashi Saito, Kazuharu Irie
BACKGROUND / AIMS: An easily available tooth storage medium is required to preserve a tooth after avulsion. Milk and Hank's balanced salt solution (HBSS) are recommended as tooth storage media, and egg white is also reported to be comparable with milk. The aim of the present study was to histologically and immunohistochemically evaluate the effect of different tooth storage media on the periodontal ligament (PDL) of extracted teeth. MATERIAL AND METHODS: This experiment used HBSS, milk and egg white as tooth storage media...
May 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28544588/the-in-vivo-th17-and-treg-immune-responses-to-aggregatibacter-actinomycetemcomitans
#3
Susan Mahabady, Natalia Tjokro, Shant Aharonian, Homayoun H Zadeh, Casey Chen, Hooman Allayee, Parish P Sedghizadeh
The periodontal pathogen Aggregatibacter actinomycetemcomitans is known to elicit systemic immune response in infected host, and occasionally causes non-oral infections. Detailed information on its immunopathological responses and the involvement of bacterial virulence factors remains to be elucidated. The aim of this study was to assess the systemic immune response to A. actinomycetemcomitans oral infection. We used an animal model that simulates systemic dissemination of the bacteria by injecting live wild type (WT) D7S-1 and double knockout mutant of leukotoxin and cytolethal distending toxin (ΔltxΔcdt) A...
May 22, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28544269/a-novel-approach-for-early-evaluation-of-orthodontic-process-by-a-numerical-thermo-mechanical-analysis
#4
Z Heidary, A Mojra, M Shirazi, M Bazargan
The main objective of this paper is to propose a novel method that provides an opportunity to evaluate an orthodontic process at early phase of the treatment. This was accomplished by finding out a correlation between the applied orthodontic force and thermal variations in the tooth structure. To this end, geometry of the human tooth surrounded by the connective soft tissue called the periodontal ligament and the bone was constructed by employing dental CT scan images of a specific case. The periodontal ligament was modeled by finite strain viscoelastic model through a nonlinear stress-strain relation (hyperelasticity) and nonlinear stress-time relation (viscoelasticity)...
May 21, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28544259/periodontal-maintenance-following-active-specialist-treatment-should-patients-stay-put-or-return-to-primary-dental-care-for-continuing-care-a-comparison-of-outcomes-based-on-the-literature
#5
REVIEW
P G Leavy, D P Robertson
OBJECTIVES: To review the evidence for the efficacy of periodontal maintenance (PM) carried out in primary dental care (PDC) compared to the specialist setting for patients previously treated in a specialist setting for chronic (ChP) or aggressive (AgP) periodontitis. METHODS: A focused PICO question and search protocol were developed. Online databases including MEDLINE, EMBASE, WEB OF SCIENCE™ and COCHRANE LIBRARY were searched along with specialist journals in the subject area of periodontal research...
May 22, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28542929/the-immune-response-to-prevotella-bacteria-in-chronic-inflammatory-disease
#6
REVIEW
Jeppe Madura Larsen
The microbiota plays a central role in human health and disease by shaping immune development, immune responses, metabolism, and protecting from invading pathogens. Technical advances that allow comprehensive characterization of microbial communities by genetic sequencing have sparked the hunt for disease modulating bacteria. Emerging studies in humans have linked increased abundance of Prevotella species at mucosal sites to localized and systemic disease, including periodontitis, bacterial vaginosis, rheumatoid arthritis, metabolic disorders, and low-grade systemic inflammation...
May 19, 2017: Immunology
https://www.readbyqxmd.com/read/28540365/the-role-of-apoptotic-factors-in-assessing-progression-of-periodontal-disease
#7
D Dabiri, S Halubai, M Layher, C Klausner, H Makhoul, G H Lin, G Eckert, H Abuhussein, P Kamarajan, Y Kapila
BACKGROUND: The mechanisms responsible for periodontal disease progression remain unclear. However, recent studies suggest that apoptosis may be one mechanism underlying the pathophysiology of periodontal disease progression. This pilot study is the 3 month follow-up of our published baseline study on the presence of apoptotic factors in serum, saliva, and gingival crevicular fluid (GCF) and their association with periodontal disease severity and activity. METHODS: GCF samples were obtained from 37 adult patients with chronic periodontitis (CP) and 7 healthy controls...
September 2016: Int J Dent Oral Sci
https://www.readbyqxmd.com/read/28539867/prevalence-of-periodontal-disease-its-association-with-systemic-diseases-and-prevention
#8
REVIEW
Muhammad Ashraf Nazir
Periodontal diseases are prevalent both in developed and developing countries and affect about 20-50% of global population. High prevalence of periodontal disease in adolescents, adults, and older individuals makes it a public health concern. Several risk factors such as smoking, poor oral hygiene, diabetes, medication, age, hereditary, and stress are related to periodontal diseases. Robust evidence shows the association of periodontal diseases with systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539291/-beneficial-effect-of-periodontal-therapy-on-insulin-resistance-and-lipid-metabolism-in-obese-rats-with-periodontitis
#9
Qiao-Xue Chai, Su-Lan Zhong, Jia Ni, Lei Chen, Lei Zhou, Jin-Cai Zhang
OBJECTIVE: To investigate the effect of periodontal therapy in controlling periodontitis and on insulin resistance and lipid metabolism in obese rats with periodontitis. METHODS: Sprague-Dawley rats were randomized into normal group (group C), obese group (group O), periodontitis combined with obesity group (group P) and periodontal treatment group (group T). The obese rats in groups P and T were subjected to ligation of the maxillary second molar with silk thread to induce experimental periodontitis, and the rats in group T received periodontal therapy after the ligation...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28538740/periodontal-status-during-pregnancy-and-postpartum
#10
Maximino González-Jaranay, Luís Téllez, Antonio Roa-López, Gerardo Gómez-Moreno, Gerardo Moreu
OBJECTIVES: Different studies have documented an association between periodontal disease and low birth-weight delivery. Hence, knowledge of periodontal status during pregnancy and postpartum is important in order to reduce the risks of both diseases. This study aimed to analyze periodontal status at successive stages of pregnancy and 3-6 weeks postpartum in women with initial periodontal alterations. MATERIALS AND METHODS: Ninety-six pregnant women were examined at 8-10 weeks (pregnancy diagnosis, baseline), 21-23 weeks and 34-36 weeks of gestation and at 40 days postpartum to record plaque scores, clinically assessed gingival inflammation and probing depth (mean depth and % sites with depth >3 mm)...
2017: PloS One
https://www.readbyqxmd.com/read/28538512/necrotizing-ulcer-after-bcg-vaccination-in-a-girl-with-leukocyte-adhesion-deficiency-type-1
#11
Hidemitsu Kurosawa, Tomoyuki Mizukami, Hiroyuki Nunoi, Masaya Kato, Yuya Sato, Mayuko Okuya, Keitaro Fukushima, Yoshihiko Katsuyama, Osamu Arisaka
Leukocyte-adhesion deficiency-1 is a recessively inherited disorder associated with recurrent bacterial infections, severe periodontitis, peripheral leukocytosis, and impaired wound healing. We diagnosed moderate-type leukocyte-adhesion deficiency-1 in a 7-year-old girl who developed a necrotizing ulcer after Bacillus Calmette-Guerin vaccination. The patient showed moderate expression of CD18 in neutrophils with a homozygous splice mutation with c.41_c.58+2dup20 of ITGB2 and experienced recurrent severe infections complicated with systemic lupus erythematosus...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28538371/comparison-of-the-efficacy-and-safety-of-2-lidocaine-hcl-with-different-epinephrine-concentration-for-local-anesthesia-in-participants-undergoing-surgical-extraction-of-impacted-mandibular-third-molars-a-multicenter-randomized-double-blind-crossover-phase-iv
#12
Myong-Hwan Karm, Fiona Daye Park, Moonkyu Kang, Hyun Jeong Kim, Jeong Wan Kang, Seungoh Kim, Yong-Deok Kim, Cheul-Hong Kim, Kwang-Suk Seo, Kyung-Hwan Kwon, Chul-Hwan Kim, Jung-Woo Lee, Sung-Woon Hong, Mi Hyoung Lim, Seung Kwan Nam, Jae Min Cho
BACKGROUND: The most commonly impacted tooth is the third molar. An impacted third molar can ultimately cause acute pain, infection, tumors, cysts, caries, periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for removing the third molar. This study aimed to evaluate the efficacy and safety of 2% lidocaine with 1:80,000 or 1:200,000 epinephrine for surgical extraction of bilateral impacted mandibular third molars. METHODS: Sixty-five healthy participants underwent surgical extraction of bilateral impacted mandibular third molars in 2 separate visits while under local anesthesia with 2% lidocaine with different epinephrine concentration (1:80,000 or 1:200,000) in a double-blind, randomized, crossover trial...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28536781/oral-health-status-in-adult-patients-with-newly-diagnosed-acute-leukemia
#13
Rilana Busjan, Justin Hasenkamp, Gerhard Schmalz, Rainer Haak, Lorenz Trümper, Dirk Ziebolz
BACKGROUND: The aim of this cross-sectional study was to evaluate the oral health of adult patients with newly diagnosed acute leukemia. METHODS: Patients with initially diagnosed acute myeloid (AML) or lymphocytic (ALL) leukemia and a matched healthy control (HC) group were included. The oral investigation comprised inspection of the oral mucosa; the decayed (D), missing (M), and filled (F) teeth (DMF-T) index; and a detailed periodontal status. Subgingival biofilm samples were analyzed (polymerase chain reaction) for the presence of selected potentially periodontal pathogenic bacteria...
May 23, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28535900/possible-links-between-osteoporosis-and-periodontal-disease
#14
Daniela Cia Penoni, Anna Thereza Thomé Leão, Tatiana Melo Fernandes, Sandra Regina Torres
No abstract text is available yet for this article.
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28535896/influence-of-periodontal-treatment-on-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#15
Débora Cerqueira Calderaro, Jôice Dias Corrêa, Gilda Aparecida Ferreira, Izabela Guimarães Barbosa, Carolina Castro Martins, Tarcília Aparecida Silva, Antônio Lúcio Teixeira
OBJECTIVE: To evaluate the influence of periodontal treatment on rheumatoid arthritis activity. METHODS: MEDLINE/PUBMED, The Cochrane Library, Clinical Trials, SciELO and LILACS were searched for studies published until December 2014. Included articles were: prospective studies; including patients older than 18 years, diagnosed with periodontitis and rheumatoid arthritis submitted to non-surgical periodontal treatment; with a control group receiving no periodontal treatment; with outcomes including at least one marker of rheumatoid arthritis activity...
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28534987/high%C3%A2-throughput-sequencing-analyses-of-oral-microbial-diversity-in-healthy-people-and-patients-with-dental-caries-and-periodontal-disease
#16
Tingtao Chen, Yan Shi, Xiaolei Wang, Xin Wang, Fanjing Meng, Shaoguo Yang, Jian Yang, Hongbo Xin
Recurrence of oral diseases caused by antibiotics has brought about an urgent requirement to explore the oral microbial diversity in the human oral cavity. In the present study, the high‑throughput sequencing method was adopted to compare the microbial diversity of healthy people and oral patients and sequence analysis was performed by UPARSE software package. The Venn results indicated that a mean of 315 operational taxonomic units (OTUs) was obtained, and 73, 64, 53, 19 and 18 common OTUs belonging to Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria, respectively, were identified in healthy people...
May 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534880/a-tale-of-two-risks-smoking-diabetes-and-the-subgingival-microbiome
#17
Sukirth M Ganesan, Vinayak Joshi, Megan Fellows, Shareef M Dabdoub, Haikady N Nagaraja, Benjamin O'Donnell, Neeta Rohit Deshpande, Purnima S Kumar
Although smoking and diabetes have been established as the only two risk factors for periodontitis, their individual and synergistic impacts on the periodontal microbiome are not well studied. The present investigation analyzed 2.7 million 16S sequences from 175 non-smoking normoglycemic individuals (controls), smokers, diabetics and diabetic smokers with periodontitis as well as periodontally healthy controls, smokers and diabetics to assess subgingival bacterial biodiversity and co-occurrence patterns. The microbial signatures of periodontally healthy smokers, but not diabetics, were highly aligned with the disease-associated microbiomes of their respective cohorts...
May 23, 2017: ISME Journal
https://www.readbyqxmd.com/read/28534138/a-chemically-modified-curcumin-cmc-2-24-inhibits-nuclear-factor-%C3%AE%C2%BAb-activation-and-inflammatory-bone-loss-in-murine-models-of-lps-induced-experimental-periodontitis-and-diabetes-associated-natural-periodontitis
#18
Muna S Elburki, Carlos Rossa, Morgana R Guimarães-Stabili, Hsi-Ming Lee, Fabiana A Curylofo-Zotti, Francis Johnson, Lorne M Golub
The purpose of this study was to assess the effect of a novel chemically modified curcumin (CMC 2.24) on NF-κB and MAPK signaling and inflammatory cytokine production in two experimental models of periodontal disease in rats. Experimental model I: Periodontitis was induced by repeated injections of LPS into the gingiva (3×/week, 3 weeks); control rats received vehicle injections. CMC 2.24, or the vehicle, was administered by daily oral gavage for 4 weeks. Experimental model II: Diabetes was induced in adult male rats by streptozotocin injection; periodontal breakdown then results as a complication of uncontrolled hyperglycemia...
May 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28534090/tooth-loss-and-liver-cancer-incidence-in-a-finnish-cohort
#19
Baiyu Yang, Jessica L Petrick, Christian C Abnet, Barry I Graubard, Gwen Murphy, Stephanie J Weinstein, Satu Männistö, Demetrius Albanes, Katherine A McGlynn
PURPOSE: Periodontal disease, a major cause of tooth loss in adults, may have systemic effects and has been associated with higher risk of several cancer types. However, the associations of periodontal disease or tooth loss with liver cancer have only been examined prospectively in two studies, neither of which had sufficient statistical power. In addition, no studies assessed the potential confounding by viral hepatitis or Helicobacter pylori infection status. METHODS: In this study, we examined the association between tooth loss and primary liver cancer incidence in a prospective cohort of Finnish male smokers (n = 29,096)...
May 22, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28533736/telescopic-overdenture-a-case-report
#20
C S Shruthi, R Poojya, Swati Ram, Anupama
PATIENT: This report describes the case of a 68 year old female patient who presented with the chief complaint of difficulty in chewing and poor aesthetics due to missing teeth. The patient was interested in saving the remaining natural teeth and desired minimal tissue coverage from the prosthesis. After consideration of all the factors involved, it was deemed advisable to resort to a palate free maxillary telescopic complete denture and a mandibular removable partial denture. DISCUSSION: Considering the age of the patient and the cost involved, implant supported prosthesis was ruled out as a treatment option for the patient...
March 2017: International Journal of Biomedical Science: IJBS
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