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https://www.readbyqxmd.com/read/28208575/rna-seq-analyses-for-two-silkworm-strains-reveals-insight-into-their-susceptibility-and-resistance-to-beauveria-bassiana-infection
#1
Dongxu Xing, Qiong Yang, Liang Jiang, Qingrong Li, Yang Xiao, Mingqiang Ye, Qingyou Xia
The silkworm Bombyx mori is an economically important species. White muscardine caused by Beauveria bassiana is the main fungal disease in sericulture, and understanding the silkworm responses to B. bassiana infection is of particular interest. Herein, we investigated the molecular mechanisms underlying these responses in two silkworm strains Haoyue (HY, sensitive to B. bassiana) and Kang 8 (K8, resistant to B. bassiana) using an RNA-seq approach. For each strain, three biological replicates for immersion treatment, two replicates for injection treatment and three untreated controls were collected to generate 16 libraries for sequencing...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28193155/a-comparison-of-reference-based-algorithms-for-correcting-cell-type-heterogeneity-in-epigenome-wide-association-studies
#2
Andrew E Teschendorff, Charles E Breeze, Shijie C Zheng, Stephan Beck
BACKGROUND: Intra-sample cellular heterogeneity presents numerous challenges to the identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a number of reference-based deconvolution algorithms have emerged, their potential remains underexplored and a comparative evaluation of these algorithms beyond tissues such as blood is still lacking. RESULTS: Here we present a novel framework for reference-based inference, which leverages cell-type specific DNAse Hypersensitive Site (DHS) information from the NIH Epigenomics Roadmap to construct an improved reference DNA methylation database...
February 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28188724/shared-genetic-variants-suggest-common-pathways-in-allergy-and-autoimmune-diseases
#3
Eskil Kreiner, Johannes Waage, Marie Standl, Susanne Brix, Tune H Pers, Alexessander Couto Alves, Nicole M Warrington, Carla Mt Tiesler, Elaine Fuertes, Lude Franke, Joel N Hirschhorn, Alan James, Angela Simpson, Joyce Y Tung, Gerard H Koppelman, Dirkje S Postma, Craig E Pennell, Marjo-Riitta Jarvelin, Adnan Custovic, Nicholas Timpson, Manuel A Ferreira, David P Strachan, John Henderson, David Hinds, Hans Bisgaard, Klaus Bønnelykke
BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: To investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms. METHODS: We meta-analyzed two GWAS on self-reported allergy and sensitization comprising a total of 62,330 individuals. These results were used to calculate enrichment for SNPs previously associated with autoimmune diseases...
February 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28185424/deconstruction-of-complex-protein-signaling-switches-a-roadmap-toward-engineering-higher-order-gene-regulators
#4
REVIEW
James A Davey, Corey J Wilson
The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, gene-function analysis, and protein manufacturing. The most successful approaches to date are based on modulating messenger RNA (mRNA) synthesis via their inducible coupling to transcriptional effectors, which requires biosensing functionality. A hallmark of biological sensing is the conversion of an exogenous signal, usually a small molecule or environmental cue such as a protein-ligand interaction, into a useful output or response...
February 9, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28182269/why-has-model-informed-precision-dosing-not-yet-become-common-clinical-reality-lessons-from-the-past-and-a-roadmap-for-the-future
#5
Adam S Darwich, Kayode Ogungbenro, Alexander A Vinks, J Robert Powell, Jean-Luc Reny, Niloufar Marsousi, Youssef Daali, David Fairman, Jack Cook, Lawrence J Lesko, Jeannine S McCune, Catherijne A J Knibbe, Saskia N de Wildt, J Steve Leeder, Michael Neely, Athena F Zuppa, Paolo Vicini, Leon Aarons, Trevor N Johnson, James Boiani, Amin Rostami-Hodjegan
Patient groups prone to polypharmacy and special subpopulations are susceptible to suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic response and/or lowering the risk of toxicity. Model-informed precision dosing (MIPD) may improve treatment outcomes by achieving the optimal dose for an individual patient. There is however relatively little published evidence of large-scale utility and impact of MIPD, where it is often implemented as local collaborative efforts between academia and healthcare...
February 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28179726/the-course-syllabus-legal-contract-or-operator-s-manual
#6
REVIEW
Martha M Rumore
A course syllabus provides a roadmap for pharmacy students to achieve course learning objectives and develop lifelong learning skills. For several decades the literature has referred to syllabi as legal documents and/or contracts between students and professors. A review of the legal precedents reveals that syllabi are not considered contracts because the courts refuse thus far to recognize educational malpractice or breach of contract as a cause of action. Syllabi do, however, represent a triggering agent for instructional dissent and grade appeals, may be binding in student appeal proceedings, and are used in judicial hearings...
December 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28179394/pathophysiology-of-migraine-a-disorder-of-sensory-processing
#7
REVIEW
Peter J Goadsby, Philip R Holland, Margarida Martins-Oliveira, Jan Hoffmann, Christoph Schankin, Simon Akerman
Plaguing humans for more than two millennia, manifest on every continent studied, and with more than one billion patients having an attack in any year, migraine stands as the sixth most common cause of disability on the planet. The pathophysiology of migraine has emerged from a historical consideration of the "humors" through mid-20th century distraction of the now defunct Vascular Theory to a clear place as a neurological disorder. It could be said there are three questions: why, how, and when? Why: migraine is largely accepted to be an inherited tendency for the brain to lose control of its inputs...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28176419/quality-assessment-of-palliative-home-care-in-italy
#8
Gianlorenzo Scaccabarozzi, Pietro Giorgio Lovaglio, Fabrizio Limonta, Maddalena Floriani, Giacomo Pellegrini
RATIONALE: The complexity of end-of-life care, represented by a large number of units caring for dying patients, of different types of organizations motivates the importance of measure the quality of provided care. Despite the law 38/2010 promulgated to remove the barriers and provide affordable access to palliative care, measurement, and monitoring of processes of home care providers in Italy has not been attempted. AIMS AND OBJECTIVES: Using data drawn by an institutional voluntary observatory established in Italy in 2013, collecting home palliative care units caring for people between January and December 2013, we assess the degree to which Italian home palliative care teams endorse a set of standards required by the 38/2010 law and best practices as emerged from the literature...
February 7, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28163048/heart-failure-with-preserved-ejection-fraction-diagnosis-and-management
#9
REVIEW
Ohad Oren, Sheldon Goldberg
Heart Failure with Preserved Ejection Fraction (HFpEF) is a prevalent condition with substantial individual and societal burden. Elucidation of the mechanisms of HFpEF is not complete. Recently, intriguing theories about the phenotypic importance of HFpEF (i.e. underlying diabetes mellitus, atrial fibrillation, obesity) have been suggested. However, it has yet to be determined if a targeted approach of that kind would help ameliorate symptoms or slow disease progression. In this article, we review the current status of understanding of HFpEF, focusing on the challenges and uncertainties regarding diagnosis and treatment...
February 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28160311/overcoming-injustice-a-roadmap-to-improve-access-to-hcv-therapy-for-our-medicaid-patients
#10
Leah Carter, Andrew Aronsohn
No abstract text is available yet for this article.
February 4, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28152962/a-patient-centered-symptom-focused-qualified-clinical-data-registry-qcdr-as-a-framework-to-guide-quality-improvement
#11
Gail Mallory, Michele Galioto
: 253 Background: Clinically meaningful quality measures have been identified as a catalyst for healthcare improvement and better patient outcomes. Amidst rapidly changing quality reporting and re-imbursement schema, eligible providers struggle to choose a portfolio of measures across multiple registries that will demonstrate the value of their practice to consumers and payers. It is critical that a roadmap to quality improvement be evident to registry users. Utilizing the Model for Improvement developed by the Associates in Process Improvement and adapted to health care by the Institute for Healthcare Improvement, a framework to guide performance improvement was developed and incorporated into an oncology specific QCDR for PQRS reporting...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152743/what-is-needed-to-implement-institute-of-medicine-iom-2013-supportive-oncology-recommendations-in-community-settings
#12
Rosa Berardi, Christine B Weldon
: 49 Background: The IOM 2013 report recommends supportive oncology services from diagnosis through survivorship and end of life. We examined what community institutions need to implement IOM recommendations. METHODS: Survey of 35 institutions in a urban area (13 cancer centers; 14 cancer support centers, 8 hospices). Institutions ranked the top 5 supportive oncology project ideas, that their organization was most interested in participating in, from a list of 27...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28148806/the-quest-for-the-ffa-and-where-it-led
#13
Nancy Kanwisher
This article tells the story behind our first paper on the fusiform face area (FFA): how we chose the question, developed the methods, and followed the data to find the FFA and subsequently many other functionally specialized cortical regions. The paper's impact had less to do with the particular findings in the paper itself and more to do with the method that it promoted and the picture of the human mind and brain that it led to. The use of a functional localizer to define a candidate region in each subject individually enabled us not just to make pictures of brain activation, but also to ask principled, hypothesis-driven questions about a thing in nature...
February 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28146177/advanced-practice-nursing-a-strategy-for-achieving-universal-health-coverage-and-universal-access-to-health
#14
Denise Bryant-Lukosius, Ruta Valaitis, Ruth Martin-Misener, Faith Donald, Laura Morán Peña, Linda Brousseau
Objective: to examine advanced practice nursing (APN) roles internationally to inform role development in Latin America and the Caribbean to support universal health coverage and universal access to health. Method: we examined literature related to APN roles, their global deployment, and APN effectiveness in relation to universal health coverage and access to health. Results: given evidence of their effectiveness in many countries, APN roles are ideally suited as part of a primary health care workforce strategy in Latin America to enhance universal health coverage and access to health...
January 30, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28145735/patient-personality-and-relational-patterns-in-psychotherapy-factor-structure-reliability-and-validity-of-the-psychotherapy-relationship-questionnaire
#15
Annalisa Tanzilli, Antonello Colli, Ivan Gualco, Vittorio Lingiardi
The aim of this study was to examine the factor structure and the psychometric properties of the Psychotherapy Relationship Questionnaire (PRQ; Bradley, Heim, & Westen, 2005 ), a clinician report instrument that measures a wide spectrum of thoughts, feelings, motives, conflicts, and behaviors expressed by patients toward their therapists in psychotherapy. A national sample of psychiatrists and clinical psychologists (N   = 314) of different theoretical orientations completed the PRQ, as well as the Shedler-Westen Assessment Procedure-200 (SWAP-200; Westen & Shedler, 1999a , 1999b ) to assess the personality of a patient in their care...
February 1, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28144680/erratum-to-preprocessing-structured-clinical-data-for-predictive-modeling-and-decision-support-a-roadmap-to-tackle-the-challenges
#16
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28140575/thermodynamics-of-phase-selection-in-mno2-framework-structures-through-alkali-intercalation-and-hydration
#17
Daniil A Kitchaev, Stephen T Dacek, Wenhao Sun, Gerbrand Ceder
While control over crystal structure is one of the primary objectives in crystal growth, the present lack of predictive understanding of the mechanisms driving structure selection precludes the predictive synthesis of polymorphic materials. We address the formation of off-stoichiometric intermediates as one such handle driving polymorph selection in the diverse class of MnO2-framework structures. Specifically, we build on the recent benchmark of the SCAN functional for the ab-initio modeling of MnO2 to examine the effect of alkali-insertion, protonation, and hydration to derive the thermodynamic conditions favoring the formation of the most common MnO2 phases - β, γ, R, α, δ, and λ - from aqueous solution...
January 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28137713/hipred-an-integrative-approach-to-predicting-haploinsufficient-genes
#18
Hashem A Shihab, Mark F Rogers, Colin Campbell, Tom R Gaunt
MOTIVATION: A major cause of autosomal dominant disease is haploinsufficiency, whereby a single copy of a gene is not sufficient to maintain the normal function of the gene. A large proportion of existing methods for predicting haploinsufficiency incorporate biological networks, e.g. protein-protein interaction networks, that have recently been shown to introduce study bias. As a result, these methods tend to perform best on well studied genes, but underperform on less studied genes. The advent of large genome sequencing consortia, such as the 1,000 genomes project, NHLBI Exome Sequencing Project (ESP) and the Exome Aggregation Consortium (ExAC) creates an urgent need for unbiased haploinsufficiency prediction methods...
January 30, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28132870/bmt-roadmap-a-user-centered-design-health-information-technology-tool-to-promote-patient-centered-care-in-pediatric-hct
#19
Lyndsey Runaas, David Hanauer, Molly Maher, Evan Bischoff, Alex Fauer, Tiffany Hoang, Anna Munaco, Roshun Sankaran, Rahael Gupta, Sajjad Seyedsalehi, Amy Cohn, Larry An, Muneesh Tewari, Sung Won Choi
Health information technology (HIT) has great potential for increasing patient engagement. Pediatric HCT is a setting ripe for using HIT but in which little research exists. "BMT Roadmap" is a web-based application that integrates patient-specific information and includes several domains: laboratory results, medications, clinical trial details, photos of the healthcare team, trajectory of transplant process, and discharge checklist. BMT Roadmap was provided to 10 caregivers of patients undergoing first-time HCT...
January 26, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28128194/a-molecular-roadmap-for-induced-multi-lineage-trans-differentiation-of-fibroblasts-by-chemical-combinations
#20
Xiaoping Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, Xia Li, Lengmei Wang, Jie Yu, Luca Pinello, Shujing Lai, Mengmeng Jiang, Xueying Tian, Fen Zhang, Yanhong Cen, Yuko Fujiwara, Wei Zhu, Bin Zhou, Tianhua Zhou, Hongwei Ouyang, Jianan Wang, Guo-Cheng Yuan, Shumin Duan, Stuart H Orkin, Guoji Guo
Recent advances have demonstrated the power of small molecules in promoting cellular reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the underlying mechanisms require further characterization. Through functional screening assays, we find that mouse embryonic fibroblast cells can be induced to trans-differentiate into a wide range of somatic lineages simultaneously by treatment with a combination of four chemicals. Genomic analysis of the process indicates activation of multi-lineage modules and relaxation of epigenetic silencing programs...
January 27, 2017: Cell Research
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