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https://www.readbyqxmd.com/read/29341609/probing-and-quantifying-the-food-borne-pathogens-and-toxins-from-in-vitro-to-in-vivo
#1
Jing-Min Liu, Zhi-Hao Wang, Hui Ma, Shuo Wang
Development of real-time and in situ analytical methods for determination of food-borne pathogens and toxins ingested into human body would be a promising research direction in the food safety area. The present review starts with summarization of the up-to-date progress of the nanomaterial-assisted in vitro detection methods for pathogens and toxins, and finally focused on application of animal bioimaging to in vivo study, including prospective strategies for in vivo quantification of target pathogens or toxins and in vivo investigation of their behaviors inside the living body, with the assistance of real-time and non-invasive optical bioimaging...
January 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29341110/eurogin-roadmap-2017-triage-strategies-for-the-management-of-hpv-positive-women-in-cervical-screening-programmes
#2
REVIEW
K Cuschieri, G Ronco, A Lorincz, L Smith, G Ogilvie, L Mirabello, F Carozzi, H Cubie, N Wentzensen, P Snijders, M Arbyn, J Monsonego J, S Franceschi
Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation. Cytology is the triage with the most follow-up data; the existence of an HR-HPV positive, cytology negative group presents a challenge and re-testing intervals for this group (and choice of re-test) require careful consideration...
January 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29339144/addressing-barriers-to-effective-cancer-immunotherapy-with-nanotechnology-achievements-challenges-and-roadmap-to-the-next-generation-of-nanoimmunotherapeutics
#3
Enping Hong, Marina A Dobrovolskaia
Cancer is a complex systemic disorder that affects many organs and tissues and arises from the altered function of multiple cellular and molecular mechanisms. One of the systems malfunctioning in cancer is the immune system. Restoring and improving the ability of the immune system to effectively recognize and eradicate cancer is the main focus of immunotherapy, a topic which has garnered recent and significant interest. The initial excitement about immunotherapy, however, has been challenged by its limited efficacy in certain patient populations and the development of adverse effects such as therapeutic resistance and autoimmunity...
January 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29338750/reperfusion-therapy-in-acute-ischemic-stroke-dawn-of-a-new-era
#4
REVIEW
Sonu Bhaskar, Peter Stanwell, Dennis Cordato, John Attia, Christopher Levi
Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, we present an extensive overview of intravenous and endovascular reperfusion strategies, recent advances in AIS neurointervention, limitations of various treatment paradigms, and provide insights on imaging-guided reperfusion therapies. A roadmap for imaging guided reperfusion treatment workflow in AIS is also proposed...
January 16, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29336923/report-on-who-meeting-on-immunization-in-older-adults-geneva-switzerland-22-23-march-2017
#5
M Teresa Aguado, Jane Barratt, John R Beard, Bonnie B Blomberg, Wilbur H Chen, Julian Hickling, Terri B Hyde, Mark Jit, Rebecca Jones, Gregory A Poland, Martin Friede, Justin R Ortiz
Many industrialized countries have implemented routine immunization policies for older adults, but similar strategies have not been widely implemented in low- and middle-income countries (LMICs). In March 2017, the World Health Organization (WHO) convened a meeting to identify policies and activities to promote access to vaccination of older adults, specifically in LMICs. Participants included academic and industry researchers, funders, civil society organizations, implementers of global health interventions, and stakeholders from developing countries with adult immunization needs...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29329372/enrichment-analysis-with-epiannotator
#6
Yoann Pageaud, Christoph Plass, Yassen Assenov
Motivation: Deciphering relevant biological insights from epigenomic data can be a challenging task. One commonly used approach is to perform enrichment analysis. However, finding, downloading and using the publicly available functional annotations requires time, programming skills and IT infrastructure. Here we describe the online tool EpiAnnotator for performing enrichment analyses on epigenomic data in a fast and user-friendly way. Results: EpiAnnotator is an R Package accompanied by a web interface...
January 10, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29326979/nanometer-precision-linear-sorting-with-synchronized-optofluidic-dual-barriers
#7
Yuzhi Shi, Sha Xiong, Lip Ket Chin, Jingbo Zhang, Wee Ser, Jiuhui Wu, Tianning Chen, Zhenchuan Yang, Yilong Hao, Bo Liedberg, Peng Huat Yap, Din Ping Tsai, Cheng-Wei Qiu, Ai Qun Liu
The past two decades have witnessed the revolutionary development of optical trapping of nanoparticles, most of which deal with trapping stiffness larger than 10-8 N/m. In this conventional regime, however, it remains a formidable challenge to sort out sub-50-nm nanoparticles with single-nanometer precision, isolating us from a rich flatland with advanced applications of micromanipulation. With an insightfully established roadmap of damping, the synchronization between optical force and flow drag force can be coordinated to attempt the loosely overdamped realm (stiffness, 10-10 to 10-8 N/m), which has been challenging...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29324240/cognitive-science-in-the-era-of-artificial-intelligence-a-roadmap-for-reverse-engineering-the-infant-language-learner
#8
Emmanuel Dupoux
Spectacular progress in the information processing sciences (machine learning, wearable sensors) promises to revolutionize the study of cognitive development. Here, we analyse the conditions under which 'reverse engineering' language development, i.e., building an effective system that mimics infant's achievements, can contribute to our scientific understanding of early language development. We argue that, on the computational side, it is important to move from toy problems to the full complexity of the learning situation, and take as input as faithful reconstructions of the sensory signals available to infants as possible...
January 8, 2018: Cognition
https://www.readbyqxmd.com/read/29323820/genetics-and-genomics-in-clinical-practice-the-views-of-wisconsin-physicians
#9
Michael P McCauley, Rebecca K Marcus, Kimberly A Strong, Alexis M Visotcky, Mary E Shimoyama, Arthur R Derse
INTRODUCTION: Decreasing costs and increased availability of genetic testing and genome sequencing mean many physicians will consider using these services over the next few years. Despite this promising future, some argue the present roadmap for translating genetics and genomics into routine clinical practice is unclear. OBJECTIVE: We conducted a pilot study to explore Wisconsin physicians' views, practices and educational desires regarding genetic and genomic testing...
June 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29323290/clonal-analysis-of-lineage-fate-in-native-haematopoiesis
#10
Alejo E Rodriguez-Fraticelli, Samuel L Wolock, Caleb S Weinreb, Riccardo Panero, Sachin H Patel, Maja Jankovic, Jianlong Sun, Raffaele A Calogero, Allon M Klein, Fernando D Camargo
Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haematopoietic compartments, the cellular intermediates, and the resulting lineage trees that emerge from them. Given that the bulk of studies addressing lineage outcomes have been performed in the context of haematopoietic transplantation, current models of lineage branching are more likely to represent roadmaps of lineage potential than native fate...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29319335/astrovirology-viruses-at-large-in-the-universe
#11
Aaron J Berliner, Tomohiro Mochizuki, Kenneth M Stedman
Viruses are the most abundant biological entities on modern Earth. They are highly diverse both in structure and genomic sequence, play critical roles in evolution, strongly influence terran biogeochemistry, and are believed to have played important roles in the origin and evolution of life. However, there is yet very little focus on viruses in astrobiology. Viruses arguably have coexisted with cellular life-forms since the earliest stages of life, may have been directly involved therein, and have profoundly influenced cellular evolution...
January 10, 2018: Astrobiology
https://www.readbyqxmd.com/read/29312744/pathway-and-application-value-of-exploration-of-the-pulmonary-artery-by-endobronchial-ultrasound
#12
Peng Li, Cen Wu, Wei Zheng, Li Zhao
Background: The current standard methods for detecting pulmonary artery diseases are pulmonary artery enhanced computed tomography (CT) scan and pulmonary arteriography. However, some patients cannot tolerate these procedures for various reasons. The present study aimed to investigate the feasibility and operation process of endobronchial ultrasound (EBUS) in exploring the pulmonary artery. Methods: Based on normal contrast-enhanced chest CT images, the sites and process for exploring the pulmonary arteries were established...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29309061/giggle-a-search-engine-for-large-scale-integrated-genome-analysis
#13
Ryan M Layer, Brent S Pedersen, Tonya DiSera, Gabor T Marth, Jason Gertz, Aaron R Quinlan
GIGGLE is a genomics search engine that identifies and ranks the significance of genomic loci shared between query features and thousands of genome interval files. GIGGLE (https://github.com/ryanlayer/giggle) scales to billions of intervals and is over three orders of magnitude faster than existing methods. Its speed extends the accessibility and utility of resources such as ENCODE, Roadmap Epigenomics, and GTEx by facilitating data integration and hypothesis generation.
January 8, 2018: Nature Methods
https://www.readbyqxmd.com/read/29304523/insights-into-3d-structure-of-adamts13-a-stepping-stone-towards-novel-therapeutic-treatment-of-thrombotic-thrombocytopenic-purpura
#14
Bogac Ercig, Kanin Wichapong, Chris P M Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry A F Nicolaes
ADAMTS13 (A D: isintegrin A: nd M: etalloprotease with a T: hromboS: pondin type-1 motif, member 13: ) and von Willebrand factor (VWF) can be considered as scale weights which control platelet adhesion during primary haemostasis. In a very uncommon condition designated thrombotic thrombocytopenic purpura (TTP), functional absence of ADAMTS13 tips the balance toward VWF-mediated platelet adhesion in the microcirculation. TTP is associated with a high mortality and arises from either a congenital or acquired autoimmune deficiency of the plasma enzyme ADAMTS13...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29296958/characterizing-the-o-glycosylation-landscape-of-human-plasma-platelets-and-endothelial-cells
#15
Sarah L King, Hiren J Joshi, Katrine T Schjoldager, Adnan Halim, Thomas D Madsen, Morten H Dziegiel, Anders Woetmann, Sergey Y Vakhrushev, Hans H Wandall
The hemostatic system comprises platelet aggregation, coagulation, and fibrinolysis, and is critical to the maintenance of vascular integrity. Multiple studies indicate that glycans play important roles in the hemostatic system; however, most investigations have focused on N-glycans because of the complexity of O-glycan analysis. Here we performed the first systematic analysis of native-O-glycosylation using lectin affinity chromatography coupled to liquid chromatography mass spectrometry (LC-MS)/MS to determine the precise location of O-glycans in human plasma, platelets, and endothelial cells, which coordinately regulate hemostasis...
February 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295602/a-general-framework-for-3-d-parameters-estimation-of-roads-using-gps-osm-and-dem-data
#16
Christophe Boucher, Jean-Charles Noyer
A growing number of applications needs GIS mapping information and commercial 3-D roadmaps especially. This paper presents a solution of accessing freely to 3-D map information and updating in the context of transport applications. The method relies on the OSM road networks that is 2-D modeled intrinsically. The objective is to estimate the road elevation and inclination parameters by fusing GPS, OSM and DEM data through a nonlinear filter. An experimental framework, using ASTER GDEM2 data, shows some results of the improvement of the roads modeling that includes their slopes also...
December 25, 2017: Sensors
https://www.readbyqxmd.com/read/29288656/functional-bowel-disorders-a-roadmap-to-guide-the-next-generation-of-research
#17
Lin Chang, Carlo Di Lorenzo, Gianrico Farrugia, Frank A Hamilton, Gary M Mawe, Pankaj J Pasricha, John W Wiley
In June 2016, the National Institutes of Health hosted a workshop on functional bowel disorders (FBDs), particularly irritable bowel syndrome, with the objective of elucidating gaps in current knowledge and recommending strategies to address these gaps. The workshop aimed to provide a roadmap to help strategically guide research efforts during the next decade. Attendees were a diverse group of internationally recognized leaders in basic and clinical FBD research. This document summarizes the results of their deliberations, including the following general conclusions and recommendations...
December 27, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29284292/the-national-rare-diseases-registry-system-nrdrs-of-china-and-the-related-cohort-studies-vision-and-roadmap
#18
Shi Feng, Shuang Liu, Chong Zhu, Mengchun Gong, Yicheng Zhu, Shuyang Zhang
Rare diseases are major challenges in healthcare and medical research and have been involved in national development strategies in many countries. However, inadequate definition of rare diseases and lags in orphan drug development in China hinder rare diseases research. The first nationwide rare diseases registry system, National Rare Diseases Registry System of China (NRDRS) has been established and various cohort studies have been launched since 2016. More than 20 top academic institutions participate in this joint effort to carry out nationwide registration of rare diseases...
December 28, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29284003/identifying-cholera-hotspots-in-uganda-an-analysis-of-cholera-surveillance-data-from-2011-to-2016
#19
Godfrey Bwire, Mohammad Ali, David A Sack, Anne Nakinsige, Martha Naigaga, Amanda K Debes, Moise C Ngwa, W Abdullah Brooks, Christopher Garimoi Orach
BACKGROUND: Despite advance in science and technology for prevention, detection and treatment of cholera, this infectious disease remains a major public health problem in many countries in sub-Saharan Africa, Uganda inclusive. The aim of this study was to identify cholera hotspots in Uganda to guide the development of a roadmap for prevention, control and elimination of cholera in the country. METHODOLOGY/PRINCIPLE FINDINGS: We obtained district level confirmed cholera outbreak data from 2011 to 2016 from the Ministry of Health, Uganda...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29281093/large-scale-determination-and-characterization-of-cell-type-specific-regulatory-elements-in-the-human-genome
#20
Can Wang, Shihua Zhang
Histone modifications have been widely elucidated to play vital roles in gene regulation and cell identity. The Roadmap Epigenomics Consortium generated a reference catalogue of several key histone modifications across > 100s of human cell types and tissues. Decoding these epigenomes into functional regulatory elements is a challenging task in computational biology. To this end, we adopted a differential chromatin modification analysis framework to comprehensively determine and characterize cell type-specific regulatory elements (CSREs) and their histone modification codes in the human epigenomes of five histone modifications across 127 tissues or cell types...
December 21, 2017: Journal of Molecular Cell Biology
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