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https://www.readbyqxmd.com/read/29781706/launch-of-an-infrastructure-for-health-research-bbmri-eric
#1
Jan-Eric Litton
Biobanking and BioMolecular resources Research Infrastructure (BBMRI)- European Research Infrastructure Consortium (ERIC) is the largest infrastructure launched in Europe in health research. By nature it is a distributed infrastructure, in which biological samples and data are hosted by the European Member States biobanks. As of today, BBMRI-ERIC consists of 19 European Member States and 1 international organization, the International Agency for Research on Cancer. This means that BBMRI-ERIC has a population of >500 million individuals in Europe...
May 21, 2018: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29777889/endovascular-management-of-a-ruptured-basilar-perforator-artery-aneurysm-associated-with-a-pontine-arteriovenous-malformation-a-case-report-and-review-of-the-literature
#2
Joseph Lockwood, Tyler Scullen, Mansour Mathkour, Ascher Kaufmann, Ricky Medel, Aaron S Dumont, Peter S Amenta
BACKGROUND: Arteriovenous malformation (AVM)-associated aneurysms are common, being reported in 15% of cases. In regards to ruptured posterior fossa AVMs, associated aneurysms are present in 48% of cases and are the etiology of the bleed in 37%. We present a 75 year-old female who presented with a subarachnoid hemorrhage (SAH) secondary to a ruptured aneurysm arising from a flow-related basilar perforator artery feeder of an anterior pontine AVM. We report the successful treatment of the aneurysm with coil embolization...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777463/considerations-that-will-determine-if-competency-based-assessment-is-a-sustainable-innovation
#3
W Dale Dauphinee, John R Boulet, John J Norcini
Educational assessment for the health professions has seen a major attempt to introduce competency based frameworks. As high level policy developments, the changes were intended to improve outcomes by supporting learning and skills development. However, we argue that previous experiences with major innovations in assessment offer an important road map for developing and refining assessment innovations, including careful piloting and analyses of their measurement qualities and impacts. Based on the literature, numerous assessment workshops, personal interactions with potential users, and our 40 years of experience in implementing assessment change, we lament the lack of a coordinated approach to clarify and improve measurement qualities and functionality of competency based assessment (CBA)...
May 18, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29777209/tuberculous-meningitis-a-roadmap-for-advancing-basic-and-translational-research
#4
Sanjay K Jain, David M Tobin, Elizabeth W Tucker, Vishwanath Venketaraman, Alvaro A Ordonez, Lakshmi Jayashankar, Omar K Siddiqi, Dima A Hammoud, Nemani V Prasadarao, Matyas Sandor, Richard Hafner, Zsuzsanna Fabry
No abstract text is available yet for this article.
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29773233/replace-a-roadmap-to-make-the-world-trans-fat-free-by-2023
#5
Tedros Adhanom Ghebreyesus, Thomas R Frieden
No abstract text is available yet for this article.
May 11, 2018: Lancet
https://www.readbyqxmd.com/read/29772177/capture-ferment-upgrade-a-three-step-approach-for-the-valorization-of-sewage-organics-as-commodities
#6
Abbas Alloul, Ramon Ganigue, Marc Spiller, Francis A Meerburg, Cristina Cagnetta, Korneel Rabaey, Siegfried E Vlaeminck
This critical review outlines a roadmap for the conversion of chemical oxygen demand (COD) contained in sewage to commodities based on three-steps: capture COD as sludge, ferment it to volatile fatty acids (VFA), and upgrade VFA to products. The article analyzes the state-of-the-art of this three-step approach and discusses the bottlenecks and challenges. The potential of this approach is illustrated for the European Union's 28 member states (EU-28) through Monte Carlo simulations. High-rate contact stabilization captures the highest amount of COD (66-86 gCOD person equivalent-1 day-1 in 60% of the iterations)...
May 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29771306/drug-screening-for-human-genetic-diseases-using-ipsc-models
#7
Matthew S Elitt, Lilianne Barbar, Paul J Tesar
Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable, scalable quantities of disease-relevant tissues from patients suffering from essentially any genetic disorder. This cellular material has proven instrumental for drug screening efforts on these disorders, and has facilitated the identification of novel therapeutics for patients. Here we will review the foundational technologies that have enabled iPSCs, the power and limitations of iPSC-based compound screens along with screening guidelines, and recent examples of screening efforts...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29765396/acute-in-stent-thrombosis-after-carotid-angioplasty-and-stenting-a-case-report-and-literature-review
#8
Wei Hu, Li Wang, GuoPing Wang
Background: Based on the results of a recent randomized controlled trial, carotid artery stenting (CAS) was regarded as a relatively safe, less invasive treatment of internal carotid artery stenosis. However, cerebral thromboembolic events are the most common complications of CAS. Especially acute stent thrombosis following CAS will be fatal without prompt diagnosis and revascularization. Case Report: We report a case of acute stent thrombosis in whom carotid revascularization was performed successfully via arterial thrombolysis and balloon postdilation...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29760735/stem-cells-for-cartilage-regeneration-a-roadmap-to-the-clinic
#9
EDITORIAL
Celeste Scotti, Alberto Gobbi, Norimasa Nakamura, Giuseppe M Peretti
No abstract text is available yet for this article.
2018: Stem Cells International
https://www.readbyqxmd.com/read/29759824/the-use-of-cardiac-ct-as-a-roadmap-for-resolving-coronary-stent-dislodgement
#10
Guillermo Torre-Amione, Erasmo de la Pena-Almaguer, Juan Quintanilla, Felipe Valdes, Vicente Jimenez, David Rodriguez, Alejandro Trevino, Luis Perez, Carlos Jerjes-Sanchez
No abstract text is available yet for this article.
May 11, 2018: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29757393/snpnexus-assessing-the-functional-relevance-of-genetic-variation-to-facilitate-the-promise-of-precision-medicine
#11
Abu Z Dayem Ullah, Jorge Oscanoa, Jun Wang, Ai Nagano, Nicholas R Lemoine, Claude Chelala
Broader functional annotation of genetic variation is a valuable means for prioritising phenotypically-important variants in further disease studies and large-scale genotyping projects. We developed SNPnexus to meet this need by assessing the potential significance of known and novel SNPs on the major transcriptome, proteome, regulatory and structural variation models. Since its previous release in 2012, we have made significant improvements to the annotation categories and updated the query and data viewing systems...
May 11, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29756767/spatially-restricting-bioorthogonal-nucleoside-biosynthesis-enables-selective-metabolic-labeling-of-the-mitochondrial-transcriptome
#12
Kim Nguyen, Mahima B Aggarwal, Chao Feng, Gabriela Balderrama, Michael Fazio, Ali Mortazavi, Robert C Spitale
The cellular RNA pool in animals arises from two separate genomes stored in the nucleus and multiple mitochondria. Chemical methods to track nascent RNA syntheses are unable to distinguish between these two with stringency. Herein we report that spatially restricting bioorthogonal nucleoside biosynthesis enables, for the first time, selective metabolic labeling of the RNA transcribed in the mitochondria. We envision this approach could open the door for heretofore-impossible analyses of mitochondrial RNA. Beyond our results revealed herein, our approach provides a roadmap for researchers to begin to design strategies to examine biomolecules within subcellular compartments...
May 14, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29755524/a-clinical-roadmap-to-investigate-the-genetic-basis-of-pediatric-pheochromocytoma-which-genes-should-physicians-think-about
#13
REVIEW
Bernardo Dias Pereira, Tiago Nunes da Silva, Ana Teresa Bernardo, Rui César, Henrique Vara Luiz, Karel Pacak, Luísa Mota-Vieira
Pheochromocytoma is very rare at a pediatric age, and when it is present, the probability of a causative genetic mutation is high. Due to high costs of genetic surveys and an increasing number of genes associated with pheochromocytoma, a sequential genetic analysis driven by clinical and biochemical phenotypes is advised. The published literature regarding the genetic landscape of pediatric pheochromocytoma is scarce, which may hinder the establishment of genotype-phenotype correlations and the selection of appropriate genetic testing at this population...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29754239/bio-algorithmic-workflows-for-standardized-synthetic-biology-constructs
#14
Angel Goñi-Moreno, Víctor de Lorenzo
A synthetic biology workflow covers the roadmap from conceptualization of a genetic device to its construction and measurement. It is composed of databases that provide DNA parts/plasmids, wet-lab methods , software tools to design circuits, simulation packages , and tools to analyze circuit performance. The interdisciplinary nature of such a workflow requires that experimental results and their in-silico counterparts proceed alongside, with constant feedback between them. We present an end-to-end use case for engineering a simple synthetic device, where information standards maintain coherence throughout the workflow...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29751688/cmos-compatible-silicon-nanowire-field-effect-transistor-biosensor-technology-development-toward-commercialization
#15
REVIEW
Duy Phu Tran, Thuy Thi Thanh Pham, Bernhard Wolfrum, Andreas Offenhäusser, Benjamin Thierry
Owing to their two-dimensional confinements, silicon nanowires display remarkable optical, magnetic, and electronic properties. Of special interest has been the development of advanced biosensing approaches based on the field effect associated with silicon nanowires (SiNWs). Recent advancements in top-down fabrication technologies have paved the way to large scale production of high density and quality arrays of SiNW field effect transistor (FETs), a critical step towards their integration in real-life biosensing applications...
May 11, 2018: Materials
https://www.readbyqxmd.com/read/29748947/nutrition-and-food-security-policy-in-the-islamic-republic-of-iran-situation-analysis-and-roadmap-towards-2021
#16
Behzad Damari, Zahra Abdollahi, Majid Hajifaraji, Arezoo Rezazadeh
Background: All government policies and programmes for food and nutrition security should include providing healthy food, as well as providing economic and social availability for all people. Aim: This study aimed to analyse the current situation of Iranian food and nutrition security and establish a road map towards 2021. Methods: The applied methods were situation analysis and a mixed qualitative-quantitative method. The conceptual method used for developing this national document encompassed three areas: sustainable food supply, food safety and nutrition...
May 3, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29748939/the-environmental-health-nexuses-within-the-strategic-roadmap-regional-work-priorities-for-the-who-eastern-mediterranean-region
#17
EDITORIAL
Ahmad Basel Al-Yousfi, Hamed Bakir, Mazen Malkawi
No abstract text is available yet for this article.
May 3, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29747898/trends-of-the-neurosurgical-economy-in-the-united-states
#18
William C Johnson, Ali Seifi
BACKGROUND: The objective of this study was to identify the neurosurgical MS-DRGs highest national bills and to analyze economic, demographic, and patient outcome trends. METHODS: This retrospective cohort study used the Nationwide Inpatient Sample (NIS) database to achieve the results. All MS-DRG codes for the years 2014 were ranked based on total aggregate charges. The highest ranked relevant to neurosurgery were identified and retrospectively reviewed to 2008...
May 7, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29740535/enhancing-the-therapeutic-efficacy-of-cancer-treatment-with-cannabinoids
#19
Sayeda Yasmin-Karim, Michele Moreau, Romy Mueller, Neeharika Sinha, Raymond Dabney, Allen Herman, Wilfred Ngwa
Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. In in vitro studies, clonogenic assay results showed greater effective tumor cell killing, when combining CBDs and RT...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29737827/improving-performances-of-in-plane-transition-metal-dichalcogenides-schottky-barrier-field-effect-transistors
#20
Zhi-Qiang Fan, Xiang-Wei Jiang, Jiezhi Chen, Jun-Wei Luo
Monolayer schottky barrier field effect transistor based on in-plane hetero-junction of 1T/1T'-phase (metallic) and 2H-phase (semiconducting) transition-metal dichalcogenide has been proposed following the recent experimental synthesis of such devices. By using density functional theory and ab initio simulations, intrinsic device performance, sub-10nm scaling, and performance boosting of MoSe2, MoTe2, WSe2, and WTe2 Schottky barrier field effect transistors are systematically investigated. We find that the Schottky barrier heights of these in-plane 1T(1T')/2H contacts are proportional to their band gaps: the bigger band gap corresponds to bigger Schottky barrier height...
May 8, 2018: ACS Applied Materials & Interfaces
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