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https://www.readbyqxmd.com/read/28818330/manufacturing-in-the-eye-of-the-storm-shen-hong-and-the-nine-great-installations-project-during-china-s-cultural-revolution
#1
Lie Sun, Danian Hu
The construction of nine high-end technical installations (hereafter Project NGI, for Nine Great Installations or ) in the 1960s and 1970s was an indispensable part of the development of China's defense and heavy industries. The project put more than 1400 machines into operation or trial operation during the Culture Revolution (1966-1976), and they served essential technical functions in sectors such as aviation, aerospace, machinery, metallurgy, and electronics, and directly advancing the development of these fields...
August 14, 2017: Endeavour
https://www.readbyqxmd.com/read/28815459/a-roadmap-for-reducing-cardiac-device-infections-a-review-of-epidemiology-pathogenesis-and-actionable-risk-factors-to-guide-the-development-of-an-infection-prevention-program-for-the-electrophysiology-laboratory
#2
REVIEW
Westyn Branch-Elliman
PURPOSE OF REVIEW: Cardiovascular implantable electronic device (CIED) infections are highly morbid, common, and costly, and rates are increasing (Sohail et al. Arch Intern Med 171(20):1821-8 2011; Voigt et al. J Am Coll Cardiol 48(3):590-1 2006). Factors that contribute to the development of CIED infections include patient factors (comorbid conditions, self-care, microbiome), procedural details (repeat procedure, contamination during procedure, appropriate pre-procedural prep, and antimicrobial use), environmental and organizational factors (patient safety culture, facility barriers, such as lack of space to store essential supplies, quality of environmental cleaning), and microbial factors (type of organism, virulence of organism)...
August 16, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28814532/developmental-process-and-early-phases-of-implementation-for-the-us-interagency-committee-on-human-nutrition-research-national-nutrition-research-roadmap-2016-2021
#3
Sheila E Fleischhacker, Rachel M Ballard, Pamela E Starke-Reed, Deborah A Galuska, Marian L Neuhouser
The Interagency Committee on Human Nutrition Research (ICHNR) is charged with improving the planning, coordination, and communication among federal agencies engaged in nutrition research and with facilitating the development and updating of plans for federal research programs to meet current and future domestic and international needs for nutrition. The ICHNR is co-chaired by the USDA Under Secretary for Research, Education, and Economics and Chief Scientist and the US Department of Health and Human Services Assistant Secretary for Health and is made up of >10 departments and agencies...
August 16, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28813649/a-case-for-a-human-immuno-peptidome-project-consortium
#4
Etienne Caron, Ruedi Aebersold, Amir Banaei-Esfahani, Chloe Chong, Michal Bassani-Sternberg
A multidisciplinary group of researchers gathered at the Hönggerberg Campus at ETH Zurich, Switzerland, for the first meeting on the Human Immuno-Peptidome Project (https://hupo.org/human-immuno-peptidome-project/). The long-term goal of this project is to map the entire repertoire of peptides presented by human leukocyte antigen molecules using mass spectrometry technologies, and make its robust analysis accessible to any immunologist. Here we outline the specific challenges identified toward this goal, and within this framework, describe the structure of a multipronged program aimed at addressing these challenges and implementing solutions at a community-wide level...
August 15, 2017: Immunity
https://www.readbyqxmd.com/read/28810144/integrated-genomic-characterization-of-pancreatic-ductal-adenocarcinoma
#5
(no author information available yet)
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28809010/bioinformatics-resources-for-interpreting-proteomics-mass-spectrometry-data
#6
Iulia M Lazar
Developments in mass spectrometry (MS) instrumentation have supported the advance of a variety of proteomic technologies that have enabled scientists to assess differences between healthy and diseased states. In particular, the ability to identify altered biological processes in a cell has led to the identification of novel drug targets, the development of more effective therapeutic drugs, and the growth of new diagnostic approaches and tools for personalized medicine applications. Nevertheless, large-scale proteomic data generated by modern mass spectrometers are extremely complex and necessitate equally complex bioinformatics tools and computational algorithms for their interpretation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808120/expert-forum-releases-roadmap-for-drug-reform
#7
Lauren Vogel
No abstract text is available yet for this article.
August 14, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28806109/reflections-on-leadership-and-governance-from-the-incident-manager-of-liberia-s-ebola-response
#8
Tolbert Nyenswah
The 2014-2016 epidemic of Ebola virus disease occurred in a region with a recent history of civil war, unstable health systems, and widespread poverty. Despite these contextual challenges, the national Ebola response in Liberia controlled transmission under strong leadership that was able to rapidly coordinate activities, to manage local and international players, and to adapt upon recognizing missteps. Such leadership has persisted to improve public health capacity in post-Ebola Liberia. This article highlights the progress made toward developing a resilient health security system with capacity to prevent, detect, and respond to disease threats before they reach epidemic level...
August 14, 2017: Health Security
https://www.readbyqxmd.com/read/28802340/improving-neonatal-care-a-global-perspective
#9
REVIEW
Danielle Yerdon Ehret, Jacquelyn Knupp Patterson, Carl Lewis Bose
Each year, approximately 2.7 million babies die during the neonatal period; more than 90% of these deaths occur in developing countries, largely from preventable causes. The known, evidence-based, simple, low-cost interventions that may improve neonatal survival often have low or unknown baseline coverage rates. Gaps in coverage of essential interventions and in quality of care may be amenable to improvement strategies. However, often these gaps are not easily identified. A variety of international organizations have recommended key indicators of quality and established roadmaps for improving neonatal outcomes...
September 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28801003/who-public-health-model-a-roadmap-for-palliative-care-development
#10
Mary V Callaway, Stephen R Connor, Kathleen M Foley
The Open Society Foundation's International Palliative Care Initiative (IPCI) began to support palliative care development in Central and Eastern Europe and the Former Soviet Union in 1999. Twenty-eight country representatives were invited to discuss the need for palliative care in their countries and to identify key areas that should be addressed to improve the care of adults and children with life-limiting illnesses. As a public health concern, progress in palliative care requires integration into health policy, education and training of health care professionals, availability of essential pain relieving medications, and health care services...
August 8, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28799142/what-to-do-in-failed-hemispherotomy-our-clinical-series-and-review-of-the-literature
#11
REVIEW
Andrea Bartoli, Y El Hassani, B Jenny, S Momjian, C M Korff, M Seeck, S Vulliemoz, K Schaller
Hemispherotomy is an established surgical technique to cure or palliate selected, mostly young patients suffering from refractory epilepsy. However, a few patients continue to have seizures despite the surgical hemispherical disconnection. We present a case series of patients who underwent redo hemispherotomy after a first unsuccessful hemispherical disconnection and provide a roadmap for subsequent workup and treatment. The institutional database of epilepsy surgery was reviewed. Twenty-four patients who underwent hemispherotomies for refractory epilepsy were identified between 2007 and 2016...
August 10, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28797534/current-status-of-therapeutic-and-vaccine-approaches-against-zika-virus
#12
REVIEW
Braira Wahid, Amjad Ali, Shazia Rafique, Muhammad Idrees
Zika virus (ZIKV) is a global threat because it is spreading at an alarming rate because of its wider range of transmission routes. The neuroteratogenic nature of ZIKV infection is posing serious threats to unborn lives therefore, it is necessary to develop an ideal ZIKV prophylactic or therapeutic agent urgently. Researchers are having tough time finding a treatment for ZIKV in part because of serious consequences of vaccines and drugs to unborn lives and pregnant women. However, in vitro and in vivo evaluation of therapeutic efficacy of DNA vaccine, recombinant subunit vaccine, and ZIKV purified inactivated vaccine offers hope for human protection...
August 7, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28793329/using-the-mwc-model-to-describe-heterotropic-interactions-in-hemoglobin
#13
Olga Rapp, Ofer Yifrach
Hemoglobin is a classical model allosteric protein. Research on hemoglobin parallels the development of key cooperativity and allostery concepts, such as the 'all-or-none' Hill formalism, the stepwise Adair binding formulation and the concerted Monod-Wymann-Changuex (MWC) allosteric model. While it is clear that the MWC model adequately describes the cooperative binding of oxygen to hemoglobin, rationalizing the effects of H+, CO2 or organophosphate ligands on hemoglobin-oxygen saturation using the same model remains controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28782717/in-silico-approaches-for-unveiling-novel-glycobiomarkers-in-cancer
#14
Rita Azevedo, André M N Silva, Celso A Reis, Lúcio Lara Santos, José Alexandre Ferreira
Glycosylation is one of the most common and dynamic post-translational modification of cell surface and secreted proteins. Cancer cells display unique glycosylation patterns that decisively contribute to drive oncogenic behavior, including disease progression and dissemination. Moreover, alterations in glycosylation are often responsible for the creation of protein signatures holding significant biomarker value and potential for targeted therapeutics. Accordingly, many analytical protocols have been outlined for the identification of abnormally glycosylated proteins by mass spectrometry...
August 4, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28782516/a-roadmap-for-improving-the-management-of-men-with-favorable-risk-prostate-cancer
#15
Gregory B Auffenberg, Brian R Lane, Susan Linsell, Andrew Brachulis, Zaojun Ye, Nikola Rakic, James Montie, David C Miller, Michael L Cher
No abstract text is available yet for this article.
August 3, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28774901/the-biology-of-color
#16
REVIEW
Innes C Cuthill, William L Allen, Kevin Arbuckle, Barbara Caspers, George Chaplin, Mark E Hauber, Geoffrey E Hill, Nina G Jablonski, Chris D Jiggins, Almut Kelber, Johanna Mappes, Justin Marshall, Richard Merrill, Daniel Osorio, Richard Prum, Nicholas W Roberts, Alexandre Roulin, Hannah M Rowland, Thomas N Sherratt, John Skelhorn, Michael P Speed, Martin Stevens, Mary Caswell Stoddard, Devi Stuart-Fox, Laszlo Talas, Elizabeth Tibbetts, Tim Caro
Coloration mediates the relationship between an organism and its environment in important ways, including social signaling, antipredator defenses, parasitic exploitation, thermoregulation, and protection from ultraviolet light, microbes, and abrasion. Methodological breakthroughs are accelerating knowledge of the processes underlying both the production of animal coloration and its perception, experiments are advancing understanding of mechanism and function, and measurements of color collected noninvasively and at a global scale are opening windows to evolutionary dynamics more generally...
August 4, 2017: Science
https://www.readbyqxmd.com/read/28767404/over-forty-years-of-bladder-cancer-glycobiology-where-do-glycans-stand-facing-precision-oncology
#17
REVIEW
Rita Azevedo, Andreia Peixoto, Cristiana Gaiteiro, Elisabete Fernandes, Manuel Neves, Luís Lima, Lúcio Lara Santos, José Alexandre Ferreira
The high molecular heterogeneity of bladder tumours is responsible for significant variations in disease course, as well as elevated recurrence and progression rates, thereby hampering the introduction of more effective targeted therapeutics. The implementation of precision oncology settings supported by robust molecular models for individualization of patient management is warranted. This effort requires a comprehensive integration of large sets of panomics data that is yet to be fully achieved. Contributing to this goal, over 40 years of bladder cancer glycobiology have disclosed a plethora of cancer-specific glycans and glycoconjugates (glycoproteins, glycolipids, proteoglycans) accompanying disease progressions and dissemination...
July 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28766204/nonoperative-management-for-invasive-breast-cancer-after-neoadjuvant-systemic-therapy-conceptual-basis-and-fundamental-international-feasibility-clinical-trials
#18
Henry M Kuerer, Marie-Jeanne T F D Vrancken Peeters, Daniel W Rea, Mark Basik, Jennifer De Los Santos, Joerg Heil
With current advances in neoadjuvant systemic therapy (NST) and improved breast imaging, the potential of nonoperative therapy for invasive breast cancer has emerged as a viable option when utilizing meticulous image-guided percutaneous biopsy to document pathologic complete response. Feasibility clinical trials utilizing this approach are being performed by teams of investigators from single and multicenter/cooperative groups around the world. Imaging alone after NST lacks sufficient sensitivity and specificity in predicting pCR and therefore cannot be utilized for clinical selection of patients for omission of surgery...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28765036/world-heart-federation-cholesterol-roadmap
#19
Adrianna Murphy, Jose R Faria-Neto, Khalid Al-Rasadi, Dirk Blom, Alberico Catapano, Ada Cuevas, Francisco Lopez-Jimenez, Pablo Perel, Raul Santos, Allan Sniderman, Rody Sy, Gerald F Watts, Dong Zhao, Salim Yusuf, David Wood
BACKGROUND: The World Heart Federation has undertaken an initiative to develop a series of Roadmaps. OBJECTIVES: The aim of these is to promote development of national policies and health systems approaches and identify potential roadblocks on the road to effective prevention, detection and management of cardiovascular disease (CVD) in low-and middle-income countries (LMIC), and strategies for overcoming these. This Roadmap focuses on elevated blood cholesterol, a leading risk factor for myocardial infarction, stroke, and peripheral arterial disease...
July 29, 2017: Global Heart
https://www.readbyqxmd.com/read/28758896/chemo-brain-or-tumor-brain-that-is-the-question-the-presence-of-extracranial-tumors-profoundly-affects-molecular-processes-in-the-prefrontal-cortex-of-tumorgraft-mice
#20
Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Svitlana Shpyleva, Stepan Melnyk, Igor Pogribny, Amanda Katz, David Sidransky, Olga Kovalchuk, Bryan Kolb
Cancer chemotherapy causes numerous persistent central nervous system complications. This condition is known as chemo brain. Cognitive impairments occur even before treatment, and hence are referred to as cancer associated cognitive changes, or tumor brain. There is much yet to be learned about the mechanisms of both chemo brain and tumor brain. The frequency and timing of chemo brain and tumor brain occurrence and persistence strongly suggest they may be epigenetic in nature and associated with altered gene expression...
July 29, 2017: Aging
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