Petr Kala, Olga Gawrys, Matúš Miklovič, Zdenka Vaňourková, Petra Škaroupková, Šárka Jíchová, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Agnieszka Walkowska, Josef Veselka, Miloš Táborský, Hana Maxová, Ivana Vaněčková, Luděk Červenka
OBJECTIVE: Evaluation of the effect of endothelin type A (ETA) receptor blockade on the course of volume-overload heart failure in rats with angiotensin II-dependent hypertension. METHODS: Ren-2 renin transgenic rats (TGR) were used as a model of hypertension. Heart failure was induced by creating an aorto-caval fistula (ACF). Selective ETA receptor blockade was achieved by atrasentan. For comparison, other rat groups received trandolapril, an angiotensin-converting enzyme inhibitor (ACEi)...
October 5, 2022: Journal of Hypertension