Keiramarie Robertson, Oliver Hahn, Beatriz G Robinson, Arwa T Faruk, Mathangi Janakiraman, Hong Namkoong, Kwangkon Kim, Jiayu Ye, Estelle Spear Bishop, Randy A Hall, Tony Wyss-Coray, Laren S Becker, Julia A Kaltschmidt
The enteric nervous system (ENS) is contained within two layers of the gut wall and is made up of neurons, immune cells, and enteric glia cells (EGCs) that regulate gastrointestinal (GI) function. EGCs in both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) change in response to inflammation, referred to as reactive gliosis. Whether EGCs restricted to a specific layer or region within the GI tract alone can influence intestinal immune response is unknown. Using bulk RNA-sequencing and in situ hybridization, we identify G-protein coupled receptor Gpr37 , as a gene expressed only in EGCs of the myenteric plexus, one of the two layers of the ENS...
April 12, 2024: bioRxiv