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https://www.readbyqxmd.com/read/29168984/transcatheter-vs-surgical-aortic-valve-replacement-in-low-to-intermediate-surgical-risk-candidates-a-meta-analysis-and-systematic-review
#1
REVIEW
Safi U Khan, Ahmad N Lone, Muhammad A Saleem, Edo Kaluski
The American and European expert documents recommend transcatheter aortic valve replacement (TAVR) for inoperable or high-surgical-risk patients with severe aortic stenosis. In comparison, efficacy of TAVR is relatively less studied in low- to intermediate-surgical-risk patients. We sought to discover whether TAVR can be as effective as surgical aortic valve replacement (SAVR) in low- to intermediate-surgical-risk candidates. Four randomized clinical trials (RCTs) and 8 prospective matched studies were selected using PubMed/MEDLINE, Embase, and Cochrane Library (inception: March 2017)...
November 23, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29168794/in-vitro-evaluation-of-pcl-and-p-3hb-as-coating-materials-for-selective-laser-melted-porous-titanium-implants
#2
Michael Grau, Julia Matena, Michael Teske, Svea Petersen, Pooyan Aliuos, Laura Roland, Niels Grabow, Hugo Murua Escobar, Nils-Claudius Gellrich, Heinz Haferkamp, Ingo Nolte
Titanium is widely used as a bone implant material due to its biocompatibility and high resilience. Since its Young's modulus differs from bone tissue, the resulting "stress shielding" could lead to scaffold loosening. However, by using a scaffold-shaped geometry, the Young's modulus can be adjusted. Also, a porous geometry enables vascularisation and bone ingrowth inside the implant itself. Additionally, growth factors can improve these effects. In order to create a deposit and release system for these factors, the titanium scaffolds could be coated with degradable polymers...
November 23, 2017: Materials
https://www.readbyqxmd.com/read/29168693/zfp281-is-essential-for-mouse-epiblast-maturation-through-transcriptional-and-epigenetic-control-of-nodal-signaling
#3
Xin Huang, Sophie Balmer, Fan Yang, Miguel Fidalgo, Dan Li, Diana Guallar, Anna-Katerina Hadjantonakis, Jianlong Wang
Pluripotency is defined by a cell's potential to differentiate into any somatic cell type. How pluripotency is transited during implantation, followed by lineage specification and establishment of the basic body plan is poorly understood. Here we report the transcription factor Zfp281 functions in the exit from naive pluripotency occurring coincident with pre-to-post-implantation mouse embryonic development. By characterizing Zfp281 mutant phenotypes and identifying Zfp281 gene targets and protein partners in developing embryos and cultured pluripotent stem cells, we establish critical roles for Zfp281 in activating components of the Nodal signaling pathway and lineage-specific genes...
November 23, 2017: ELife
https://www.readbyqxmd.com/read/29168642/a-new-swallowable-intragastric-balloon-elipse%C3%A2-coffee-for-everybody-the-position-of-gettemo
#4
Eduardo Espinet Coll, Javier Nebreda Durán, Gontrand López-Nava Breviere
Recently, the Elipse® swallow balloon with spontaneous evacuation has been incorporated. GETTEMO wants to position defending innovations in endoscopic treatment of bariatric patients, including this new gastric balloon. Any bariatric endoscopic procedure must always be done within a suitable protocol and in a Multidisciplinary Unit. In order to ensure maximum safety and to be able to effectively solve potential complications, in most of the cases a prior endoscopy should be required to rule out complications, the balloon must be implanted (or supervised) by a bariatric endoscopist and it is necessary to have an Endoscopic Emergency Department...
November 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29168622/mitral-valve-pressure-gradient-after-percutaneous-mitral-valve-repair-every-beat-counts
#5
Daniel Lavall, Bruno Scheller, Christian Werner, Axel Buob, Felix Mahfoud
A patient presented with symptoms of decompensated heart failure 2 months after percutaneous mitral valve (MV) repair. Echocardiography demonstrated impaired left ventricular function with elevated MV pressure gradients and pulmonary pressures during rapid atrial fibrillation. Heart rate control was achieved by implantation of a biventricular pacemaker with subsequent His-bundle ablation because atrial fibrillation was refractory to medical treatment. During biventricular pacing at different rates (50-110 b...
November 23, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29168595/berberine-impairs-embryonic-development-in-vitro-and-in-vivo-through-oxidative-stress-mediated-apoptotic-processes
#6
Chien-Hsun Huang, Zi-Wei Huang, Feng-Ming Ho, Wen-Hsiung Chan
Berberine, an isoquinoline alkaloid isolated from several traditional Chinese herbal medicines, has been shown to suppress growth and induce apoptosis in some tumor cell lines. However, berberine has also been reported to attenuate H2 O2 -induced oxidative injury and apoptosis. The basis for these ambiguous effects of berberine-triggering or preventing apoptosis-has not been well characterized to date. In the current investigation, we examined whether berberine exerts cytotoxic effects on mouse embryos at the blastocyst stage and affects subsequent embryonic development in vitro and in vivo...
November 23, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29168549/first-polish-analysis-of-the-treatment-of-advanced-heart-failure-in-children-with-the-use-of-berlinheart-excor-mechanical-circulatory-support
#7
Szymon Pawlak, Roman Przybylski, Janusz Skalski, Joanna Śliwka, Andrzej Kansy, Adam Grzybowski, Arkadiusz Wierzyk, Jacek Białkowski, Bohdan Maruszewski, Marian Zembala
BACKGROUND: The treatment of advanced heart failure in children and infants poses a serious management problem. Heart failure in that patient group is usually of congenital etiology. The treatment schedules for pediatric patients are in most cases adapted from the guidelines for treatment of adults. Up to 2009, the treatment of that extremely difficult group of patients was limited to pharmacological therapy and occasional heart transplantations. Constantly increasing problems with recruiting donors, especially for the pediatric group, contribute to the fact that mechanical support with the use of ventricular assist devices is for many children the only chance to survive the period of waiting for a heart donor...
November 23, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29168547/gastric-contractility-modulation-a-novel-method-for-the-treatment-of-type-2-diabetes-mellitus-and-obesity
#8
Jarosław Kozakowski, Harold E Lebovitz, Wojciech Zgliczyński, Wiesław Tarnowski
Because the majority of antidiabetic medications are of limited efficacy and patient compliance with treatment is usually poor, new therapies are still being searched for. In the review a newly developed system for treatment of subjects with type 2 diabetes and concomitant overweight/obesity is described. The system consists of an implantable pulse generator that delivers electrical stimuli through leads implanted in the sero-muscular layer of the stomach. The device recognises and automatically modulates natural electrical activity of the stomach during meals, strengthening gastric contractility...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29168541/evaluation-of-bioresorbable-vascular-scaffolds-in-acute-coronary-syndrome-a-two-center-one-year-follow-up-analysis
#9
Sylwia Iwańczyk, Jarosław Hiczkiewicz, Aleksander Araszkiewicz, Magdalena Łanocha, Daria Adamczak, Wojciech Faron, Stefan Grajek, Maciej Lesiak
BACKGROUND: Bioresorbable vascular scaffolds (BVS) have emerged as a new treatment option in cardiovascular medicine. Nonetheless, there is still limited data on the use of these novel devices in patients with acute coronary syndromes (ACS). The purpose of this study was to evaluate the feasibility and efficacy of BVS implantation in patients with ACS. METHODS: The present report is a prospective, two-centre registry that involved 165 consecutive patients hospitalized with the diagnosis of ACS and treated with the Absorb BVS (Abbot Vascular, Santa Clara, USA)...
November 23, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29168462/potential-benefit-of-optimizing-atrioventricular-interventricular-delays-in-patients-with-cardiac-resynchronization-therapy
#10
Bozena Urbanek, Krzysztof Kaczmarek, Artur Klimczak, Jan Ruta, Michal Chudzik, Katarzyna Piestrzeniewicz, Pawel Ptaszynski, Jerzy Krzysztof Wranicz
BACKGROUND & OBJECTIVES: The clinical benefit of optimization (OPT) of atrioventricular delay (AVD) and interventricular delay (VVD) in cardiac resynchronization therapy (CRT) remains debatable. This study was aimed to determine the influence of AVD and VVD OPT on selected parameters in patients early after CRT implantation and at mid-term follow up (FU). METHODS: Fifty two patients (61±10 yr, 23 males) with left bundle branch block, left ventricular ejection fraction (LVEF) ≤35 per cent and heart failure were selected for CRT implantation...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168434/changes-in-knee-shape-and-geometry-resulting-from-total-knee-arthroplasty
#11
Mohsen Akbari Shandiz, Paul Boulos, Stefan Karl Saevarsson, Heiko Ramm, Chun Kit Jack Fu, Stephen Miller, Stefan Zachow, Carolyn Anglin
Changes in knee shape and geometry resulting from total knee arthroplasty can affect patients in numerous important ways: pain, function, stability, range of motion, and kinematics. Quantitative data concerning these changes have not been previously available, to our knowledge, yet are essential to understand individual experiences of total knee arthroplasty and thereby improve outcomes for all patients. The limiting factor has been the challenge of accurately measuring these changes. Our study objective was to develop a conceptual framework and analysis method to investigate changes in knee shape and geometry, and prospectively apply it to a sample total knee arthroplasty population...
November 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29168329/percutaneous-bone-anchored-hearing-system-implant-survival-after-550-primary-implant-surgeries
#12
T G A Calon, J van Tongeren, A M E Heuft, J W Brunings, D Bollen, J R Hof, R J Stokroos
The Bone Anchored Hearing System (BAHS) has become an established option for rehabilitation of several type of hearing impairment such as conductive hearing loss, mixed hearing loss and single sided deafness (1) . Overall good outcomes have been reported. Nevertheless, complications such as inflammation of the skin around the percutaneous abutment, pain and implant loss are related to BAHS (2) . This article is protected by copyright. All rights reserved.
November 23, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29168070/arterial-pulse-attenuation-prediction-using-the-decaying-rate-of-a-pressure-wave-in-a-viscoelastic-material-model
#13
J Menacho, L Rotllant, J J Molins, G Reyes, A A García-Granada, M Balcells, J Martorell
The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood pulse propagation remains to be fully understood. Several materials for medical applications, such as medical polydimethylsiloxane or polytetrafluoroethylene, show viscoelastic behavior, modifying the original vessel stiffness and affecting the propagation of blood pulses...
November 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29168022/no-advantage-of-fresh-blastocyst-versus-cleavage-stage-embryo-transfer-in-women-under-the-age-of-39-a-randomized-controlled-study
#14
Paolo Emanuele Levi-Setti, Federico Cirillo, Antonella Smeraldi, Emanuela Morenghi, Giulia E G Mulazzani, Elena Albani
PURPOSE: Is there a difference in implantation and pregnancy rates between embryos transferred electively at cleavage or blastocyst stage in infertile women ≤ 38 years with at least four zygotes on day 1 post retrieval? METHODS: A randomized clinical trial was conducted in a single tertiary care hospital with a sample size of 194 patients in each arm for a total population of 388 women. Patients less than 39 years of age with more than three fertilized oocytes and less than four previous assisted reproductive technology (ART) attempts were inclusion criteria...
November 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29167979/good-results-with-minimally-invasive-unicompartmental-knee-resurfacing-after-10-year-follow-up
#15
Martin H Redish, Peter Fennema
The current study was designed to determine (1) 10-year implant survival and (2) patient's self-reported functional outcome in a single surgeon's consecutive cohort of patients who had undergone minimally invasive unicondylar resurfacing with a modified cementation technique utilizing a cobalt-chromium femur/inlaid all-PE tibia, fixed-bearing unicompartmental prosthesis. We included 344 consecutive patients (361 knees) who had received the study device between January 2002 and December 2005 in this retrospective study...
November 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29167954/no-implant-migration-and-good-subjective-outcome-of-a-novel-customized-femoral-resurfacing-metal-implant-for-focal-chondral-lesions
#16
Anders Stålman, Olof Sköldenberg, Nicolas Martinez-Carranza, David Roberts, Magnus Högström, Leif Ryd
PURPOSE: Managing focal cartilage injuries in the middle-aged patient poses a challenge. Focal prosthetic inlay resurfacing has been proposed to be a bridge between biologics and conventional joint arthroplasty. Patient selection and accurate implant positioning is crucial to avoid increased contact pressure to the opposite cartilage surface. A customized femoral condyle implant for focal cartilage injuries was designed to precisely fit each patient's individual size and location of damage...
November 22, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29167904/prevalence-characteristics-and-treatment-patterns-of-hearing-difficulty-in-the-united-states
#17
Hossein Mahboubi, Harrison W Lin, Neil Bhattacharyya
Importance: Hearing loss is one of the most prevalent chronic conditions in the United States and has been associated with negative physical, social, cognitive, economic, and emotional consequences. Despite the high prevalence of hearing loss, substantial gaps in the utilization of amplification options, including hearing aids and cochlear implants (CI), have been identified. Objective: To investigate the contemporary prevalence, characteristics, and patterns of specialty referral, evaluation, and treatment of hearing difficulty among adults in the United States...
November 22, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29167796/tinnitus-after-simultaneous-and-sequential-bilateral-cochlear-implantation
#18
Geerte G J Ramakers, Véronique J C Kraaijenga, Yvette E Smulders, Alice van Zon, Inge Stegeman, Robert J Stokroos, Rolien H Free, Johan H M Frijns, Wendy J Huinck, Gijsbert A Van Zanten, Wilko Grolman
Importance: There is an ongoing global discussion on whether or not bilateral cochlear implantation should be standard care for bilateral deafness. Contrary to unilateral cochlear implantation, however, little is known about the effect of bilateral cochlear implantation on tinnitus. Objective: To investigate tinnitus outcomes 1 year after bilateral cochlear implantation. Secondarily, to compare tinnitus outcomes between simultaneous and sequential bilateral cochlear implantation and to investigate long-term follow-up (3 years)...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29167746/comparison-of-in-vivo-antibacterial-and-antithrombotic-activities-of-two-types-of-pulmonary-artery-catheters-in-pig
#19
Jung Wook Han, Yeon Soo Shin, Jung Ju Kim, Ho Sung Son
Background: During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications. Method: In order to develop a new PAC material, we evaluated the antibacterial and antithrombotic activities of the two types of PAC (Swan Ganz catheter and prototype catheter) in 14 pigs. Results: In the 3-day group, bacterial infection rate was not different between the two types of PAC...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29167726/effects-of-hydroalcoholic-extract-of-soy-on-learning-memory-and-synaptic-plasticity-deficits-induced-by-seizure-in-ovariectomized-rats
#20
Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Fariba Sharififar, Vahid Sheibani
Introduction: Previous studies have shown that seizure can induce cognitive impairment. On the other hand, soy phytoestrogens, which are mainly found in soybean (Glycine max (L.) Merr.), have beneficial effects on the nervous system. However, little is known about their probable effects on seizure. The present study aimed to examine the probable effects of soy extract, containing the phytoestrogen genistein on seizure-induced cognitive and synaptic plasticity impairment in Ovariectomized (OVX) rats...
September 2017: Basic and Clinical Neuroscience
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