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https://www.readbyqxmd.com/read/29471389/the-effect-of-paternal-factors-on-perinatal-and-paediatric-outcomes-a-systematic-review-and-meta-analysis
#1
Nan B Oldereid, Ulla-Britt Wennerholm, Anja Pinborg, Anne Loft, Hannele Laivuori, Max Petzold, Liv Bente Romundstad, Viveca Söderström-Anttila, Christina Bergh
BACKGROUND: Maternal factors, including increasing childbearing age and various life-style factors, are associated with poorer short- and long-term outcomes for children, whereas knowledge of paternal parameters is limited. Recently, increasing paternal age has been associated with adverse obstetric outcomes, birth defects, autism spectrum disorders and schizophrenia in children. OBJECTIVE AND RATIONALE: The aim of this systematic review is to describe the influence of paternal factors on adverse short- and long-term child outcomes...
February 15, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29468985/the-role-of-neurohypophyseal-hormones-vasopressin-and-oxytocin-in-neuropsychiatric-disorders
#2
Michele Iovino, Tullio Messana, Giovanni De Pergola, Emanuela Iovino, Franca Dicuonzo, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani
Although the neurohypophyseal hormones vasopressin and oxytocin are mostly known for their role respectively in antiduresis the former and in labour, lactation and maternal behavior the latter, both might exert widespread influences either on emotion and cognition in healthy subjects, showing some gender-related differences. They interact one each other facilitating shifts between positive socially- oriented and defensive states. In fact, vasopressin amplifies the reactivity to stressors showing also beneficial effects on attention, verbal learning as well as memory, whereas oxytocin reduces the amplitude of the stress response, improves emotion processing, and can play a negative effect on memory and verbal learning in healthy individuals...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468815/isothiocyanates-translating-the-power-of-plants-to-people
#3
REVIEW
Dushani L Palliyaguru, Jian-Min Yuan, Thomas W Kensler, Jed W Fahey
Isothiocyanates from cruciferous vegetables have been studied extensively in cells and in animals for their disease preventive and therapeutic effects. However, translating their utility to human populations has been both limited and challenging. Herein, clinical trials employing two isothiocyanates, sulforaphane (SFN; 1-Isothiocyanato-4-(methylsulfinyl) butane) and phenethyl isothiocyanate (PEITC; 2-isothiocyanatoethylbenzene) that are isolated principally from broccoli and watercress, respectively, are summarized and discussed...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29468576/evaluating-sex-and-age-differences-in-adi-r-and-ados-scores-in-a-large-european-multi-site-sample-of-individuals-with-autism-spectrum-disorder
#4
J Tillmann, K Ashwood, M Absoud, S Bölte, F Bonnet-Brilhault, J K Buitelaar, S Calderoni, R Calvo, R Canal-Bedia, R Canitano, A De Bildt, M Gomot, P J Hoekstra, A Kaale, H McConachie, D G Murphy, A Narzisi, I Oosterling, M Pejovic-Milovancevic, A M Persico, O Puig, H Roeyers, N Rommelse, R Sacco, V Scandurra, A C Stanfield, E Zander, T Charman
Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity...
February 21, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29468575/autism-spectrum-traits-linked-with-reduced-performance-on-self-report-behavioural-measures-of-cognitive-flexibility
#5
Natalia Albein-Urios, George J Youssef, Melissa Kirkovski, Peter G Enticott
Deficits in cognitive flexibility are thought to underpin the core symptom of repetitive and restricted patterns of behaviour in autism spectrum disorder (ASD). Studies investigating this relationship, however, report inconsistent results. This is partly due to the variable nature of measures used to assess the construct of flexibility. The main purpose of this study was to investigate whether ASD traits differentially predict cognitive flexibility performance on lab-based neurocognitive measures relative to behavioural self-reports in a non-clinical sample of young adults...
February 21, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29468499/resveratrol-improves-neuroimmune-dysregulation-through-the-inhibition-of-neuronal-toll-like-receptors-and-cox-2-signaling-in-btbr-t-itpr3-tf-j-mice
#6
Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Mohammad Z Alzahrani, Saleh A Bakheet, Sabry M Attia
Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments in communication, repetitive and social interaction, restricted, and stereotyped patterns of behavior. Resveratrol has been extensively studied pharmacologically and biologically and has anti-inflammatory, antioxidant, and neuroprotective effects on neuronal damage in neurodegenerative disorders. The BTBR T+ Itpr3tf /J (BTBR) autistic mouse model has been explored for treatment of autism, which shows low reciprocal social interactions, impaired juvenile play, and decreased social approach...
February 21, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29467790/classification-of-autism-spectrum-disorder-using-random-support-vector-machine-cluster
#7
Xia-An Bi, Yang Wang, Qing Shu, Qi Sun, Qian Xu
Autism spectrum disorder (ASD) is mainly reflected in the communication and language barriers, difficulties in social communication, and it is a kind of neurological developmental disorder. Most researches have used the machine learning method to classify patients and normal controls, among which support vector machines (SVM) are widely employed. But the classification accuracy of SVM is usually low, due to the usage of a single SVM as classifier. Thus, we used multiple SVMs to classify ASD patients and typical controls (TC)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29467497/altered-taok2-activity-causes-autism-related-neurodevelopmental-and-cognitive-abnormalities-through-rhoa-signaling
#8
Melanie Richter, Nadeem Murtaza, Robin Scharrenberg, Sean H White, Ole Johanns, Susan Walker, Ryan K C Yuen, Birgit Schwanke, Bianca Bedürftig, Melad Henis, Sarah Scharf, Vanessa Kraus, Ronja Dörk, Jakob Hellmann, Zsuzsa Lindenmaier, Jacob Ellegood, Henrike Hartung, Vickie Kwan, Jan Sedlacik, Jens Fiehler, Michaela Schweizer, Jason P Lerch, Ileana L Hanganu-Opatz, Fabio Morellini, Stephen W Scherer, Karun K Singh, Froylan Calderon de Anda
Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to NDDs is unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and knockout (KO) mice and found gene dosage-dependent impairments in cognition, anxiety, and social interaction. Taok2 Het and KO mice also have dosage-dependent abnormalities in brain size and neural connectivity in multiple regions, deficits in cortical layering, dendrite and synapse formation, and reduced excitatory neurotransmission...
February 21, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29466819/feasibility-testing-of-a-wearable-behavioral-aid-for-social-learning-in-children-with-autism
#9
Jena Daniels, Nick Haber, Catalin Voss, Jessey Schwartz, Serena Tamura, Azar Fazel, Aaron Kline, Peter Washington, Jennifer Phillips, Terry Winograd, Carl Feinstein, Dennis P Wall
BACKGROUND:  Recent advances in computer vision and wearable technology have created an opportunity to introduce mobile therapy systems for autism spectrum disorders (ASD) that can respond to the increasing demand for therapeutic interventions; however, feasibility questions must be answered first. OBJECTIVE:  We studied the feasibility of a prototype therapeutic tool for children with ASD using Google Glass, examining whether children with ASD would wear such a device, if providing the emotion classification will improve emotion recognition, and how emotion recognition differs between ASD participants and neurotypical controls (NC)...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29465765/the-role-of-general-anesthesia-on-traits-of-neurodevelopmental-disorders-in-a-swedish-cohort-of-twins
#10
Albert Castellheim, Sebastian Lundström, Mattias Molin, Ralf Kuja-Halkola, Carina Gillberg, Christopher Gillberg
BACKGROUND: The role of general anesthetics as a risk factor for possible neurodevelopmental disorders (NDDs) in humans is unresolved. The investigation of the role of anesthetics in the development of postgeneral anesthesia (anesthesia onward) NDDs has proven to be complicated, partly because of the inherent confounding in clinical cohort studies, and partly by the fact that anesthetics are only one part in the complex process of anesthesia-surgery. METHODS: Utilizing the Swedish databases Child and Adolescent Twins Study in Sweden (CATSS) and National Patient Register (NPR), we investigated twins discordant for anesthesia, born between 1997 and 2004 for traits of NDDs...
February 21, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29463108/coping-and-care-related-stress-in-parents-of-a-child-with-autism-spectrum-disorder
#11
Daniel Shepherd, Jason Landon, Steve Taylor, Sonja Goedeke
BACKGROUND AND OBJECTIVES: Parenting a child with Autism Spectrum Disorder (ASD) is challenging and can result in elevated levels of parenting stress. This study investigated the relationship between parent-ratings of their child's ASD symptoms and two conceptually different measures of parenting stress: One specific to the ASD context and the other a general stress measure applicable to the broader caregiving context. Additionally, the influence of coping style on the relationship between child's ASD symptoms and parenting stress was investigated...
February 20, 2018: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/29463073/t-type-calcium-channels-are-required-to-maintain-viability-of-neural-progenitor-cells
#12
Ji-Woon Kim, Hyun Ah Oh, Sung Hoon Lee, Ki Chan Kim, Pyung Hwa Eun, Mee Jung Ko, Edson Luck T Gonzales, Hana Seung, Seonmin Kim, Geon Ho Bahn, Chan Young Shin
T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube defects. However, their function during embryonic development is largely unknown. Here, we investigated the function and expression of T-type calcium channels in embryonic neural progenitor cells (NPCs). First, we compared the expression of T-type calcium channel subtypes (CaV3...
February 21, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29462954/autism-treatment-evaluation-checklist-atec-norms-a-growth-chart-for-atec-score-changes-as-a-function-of-age
#13
Shreyas Mahapatra, David Vyshedsky, Samantha Martinez, Benjamin Kannel, Julia Braverman, Stephen M Edelson, Andrey Vyshedskiy
Most early-intervention Autism Spectrum Disorder (ASD) clinical trials are limited by the availability of psychometric technicians who assess each child's abilities before and after therapeutic intervention. If parents could administer regular psychometric evaluations of their children, then the cost of clinical trials will be reduced, enabling longer clinical trials with the larger number of participants. The Autism Treatment Evaluation Checklist (ATEC) was designed nearly two decades ago to provide such a tool, but the norms on the longitudinal changes in ATEC in the "treatment as usual" population were lacking...
February 16, 2018: Children
https://www.readbyqxmd.com/read/29462110/strain-differences-in-the-susceptibility-to-the-gut-brain-axis-and-neurobehavioural-alterations-induced-by-maternal-immune-activation-in-mice
#14
Livia H Morais, Daniela Felice, Anna V Golubeva, Gerard Moloney, Timothy G Dinan, John F Cryan
There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher susceptibility to neurodevelopmental abnormalities. The maternal immune activation (MIA) rodent model is a valuable tool for elucidating the basis of this interaction. We induced MIA with polyinosinic-polycytidylic acid (poly I:C) at gestational day 12...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29461904/an-investigation-of-the-association-between-seizures-autism-symptomology-and-developmental-functioning-in-young-children
#15
Claire O Burns, Johnny L Matson
OBJECTIVE: The aim of the present study was to explore whether a history of seizures was associated with autism symptom severity and developmental functioning in young children. METHODS: Autism symptom severity and developmental functioning were compared between children with and without a history or seizures who either had atypical development or met criteria for autism spectrum disorder (ASD) based on review of records by a licensed clinical psychologist. RESULTS: Parents of children who met criteria for ASD reported lower levels of autism symptomology when the child had a history of seizures, while the opposite trend was found for children with atypical development...
February 20, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29461878/experience-of-parents-of-children-with-autism-on-youtube-are-there-educationally-useful-videos
#16
Samy A Azer, Raghad A Bokhari, Ghadah S AlSaleh, May M Alabdulaaly, Khawlah I Ateeq, Anthony P S Guerrero, Sarah Azer
The aims of this study were to determine the following: first, are there educationally useful videos of parents of children with autism sharing their experiences? Second, do any of the data related to videos help in identifying useful videos? And third, what do posted comments tell us? YouTube was searched for videos of parents sharing their experiences. The following parameters were collected: title, creator, URL, duration, number of viewers, likes, dislikes, comments, days on YouTube, and country. Based on agreed-upon criteria, videos were divided independently into educationally useful and non-useful categories...
February 20, 2018: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/29460820/association-between-mental-disorders-cognitive-disturbances-and-vitamin-d-serum-level-current-state
#17
Paul P Lerner, Laura Sharony, Chanoch Miodownik
BACKGROUND & AIMS: Vitamin D deficiency has been identified as a global problem. Approximately 14% of the world population has inadequate vitamin D levels. This vitamin has been usually associated with bone disorders such as rickets, osteomalacia, and osteoporosis. However, these disorders present only a small part of all the disturbances which can be induced by its deficiency. Low serum vitamin D is associated with development of cardiovascular diseases, hypertension, neurodegenerative diseases, diabetes mellitus, metabolic syndrome and even cancer...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460795/evidence-the-u-s-autism-epidemic-initiated-by-acetaminophen-tylenol-is-aggravated-by-oral-antibiotic-amoxicillin-clavulanate-augmentin-and-now-exponentially-by-herbicide-glyphosate-roundup
#18
Peter Good
Because certain hereditary diseases show autistic behavior, and autism often runs in families, researchers seek genes underlying the pathophysiology of autism, thus core behaviors. Other researchers argue environmental factors are decisive, citing compelling evidence of an autism epidemic in the United States beginning about 1980. Recognition that environmental factors influence gene expression led to synthesis of these views - an 'epigenetic epidemic' provoked by pervasive environmental agents altering expression of vulnerable genes, inducing characteristic autistic biochemistries in many mothers and infants...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29459836/treating-depression-with-transcutaneous-auricular-vagus-nerve-stimulation-state-of-the-art-and-future-perspectives
#19
Jian Kong, Jiliang Fang, Joel Park, Shaoyuan Li, Peijing Rong
Depression is a highly prevalent disorder, and its treatment is far from satisfactory. There is an urgent need to develop a new treatment for depression. Although still at its early stage, transcutaneous auricular vagus nerve stimulation (taVNS) has shown promising potential for treating depression. In this article, we first summarize the results of clinical studies on the treatment effect of taVNS on depression. Then, we re-analyze a previous study to identify the specific symptoms taVNS can relieve as indicated by subscores of the 24-item Hamilton Depression Scale in patients with depression...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29459832/variations-of-the-functional-brain-network-efficiency-in-a-young-clinical-sample-within-the-autism-spectrum-a-fnirs-investigation
#20
Yanwei Li, Dongchuan Yu
Autism is a neurodevelopmental disorder with dimensional behavioral symptoms and various damages in the structural and functional brain. Previous neuroimaging studies focused on exploring the differences of brain development between individuals with and without autism spectrum disorders (ASD). However, few of them have attempted to investigate the individual differences of the brain features among subjects within the Autism spectrum. Our main goal was to explore the individual differences of neurodevelopment in young children with Autism by testing for the association between the functional network efficiency and levels of autistic behaviors, as well as the association between the functional network efficiency and age...
2018: Frontiers in Physiology
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