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Alexandra Sufit, Alisa B Lee-Sherick, Deborah DeRyckere, Manali Rupji, Bhakti Dwivedi, Marileila Varella-Garcia, Angela M Pierce, Jeanne Kowalski, Xiaodong Wang, Stephen V Frye, H Shelton Earp, Amy K Keating, Douglas K Graham
BACKGROUND: MER receptor tyrosine kinase (MERTK) is expressed in a variety of malignancies, including glioblastoma multiforme (GBM). Our previous work demonstrated that inhibition of MERTK using RNA interference induced cell death and chemosensitivity in GBM cells, implicating MERTK as a potential therapeutic target. Here we investigate whether a novel MERTK-selective small molecule tyrosine kinase inhibitor, UNC2025, has similar anti-tumor effects in GBM cell lines. METHODS: Correlations between expression of GAS6, a MERTK ligand, and prognosis were determined using data from the TCGA database...
2016: PloS One
Daniel Summer Gareau, Joel Correa da Rosa, Sarah Yagerman, John A Carucci, Nicholas Gulati, Ferran Hueto, Jennifer L DeFazio, Mayte Suárez-Farinas, Ashfaq Marghoob, James G Krueger
We developed an automated approach for generating quantitative image analysis metrics (imaging biomarkers) that are then analyzed with a set of thirteen machine-learning algorithms to generate an overall risk score that is called a Q-score. These methods were applied to a set of 120 "difficult" dermoscopy images of dysplastic nevi and melanomas that were subsequently excised/classified. This approach yielded 98% sensitivity and 36% specificity for melanoma detection, approaching sensitivity/specificity of expert lesion evaluation...
October 26, 2016: Experimental Dermatology
Soo Hyeon Lim, Eun-Young Ahn, Youmie Park
Gold nanoparticles were synthesized using a water extract of Artemisia capillaris (AC-AuNPs) under different extract concentrations, and their catalytic activity was evaluated in a 4-nitrophenol reduction reaction in the presence of sodium borohydride. The AC-AuNPs showed violet or wine colors with characteristic surface plasmon resonance bands at 534~543 nm that were dependent on the extract concentration. Spherical nanoparticles with an average size of 16.88 ± 5.47~29.93 ± 9.80 nm were observed by transmission electron microscopy...
December 2016: Nanoscale Research Letters
P G Negueroles, E Bou-Belda, L Santos-Juanes, A M Amat, A Arques, R F Vercher, P Monllor, R Vicente
In this paper, the possibility of reusing textile effluents for new dyeing baths has been investigated. For this purpose, different trichromies using Direct Red 80, Direct Blue 106, and Direct Yellow 98 on cotton have been used. Effluents have been treated by means of a photo-Fenton process at pH 5. Addition of humic-like substances isolated form urban wastes is necessary in order to prevent iron deactivation because of the formation of non-active iron hydroxides. Laboratory-scale experiments carried out with synthetic effluents show that comparable results were obtained when using as solvent water treated by photo-Fenton with SBO and fresh deionized water...
October 25, 2016: Environmental Science and Pollution Research International
B Vega-Sánchez, S Ortega-García, J Ruelas-Inzunza, M Frías-Espericueta, O Escobar-Sánchez, J Guzmán-Rendón
With the aim of knowing annual variations of Hg concentrations in muscle and liver of blue marlin (Makaira nigricans) from the southern Gulf of California, fish were collected between 2005 and 2012 in three areas. In general, Hg levels were more elevated in liver than in muscle. Variations of Hg concentrations in muscle and liver among the studied years were not significant. Hg levels in muscle and liver increased significantly with length and weight of fish. In comparison to other studies, Hg levels in muscle and liver were lower...
October 25, 2016: Bulletin of Environmental Contamination and Toxicology
Konstantinos Rallis, George D Kymionis, Ilias Georgalas, Marilita M Moschos, Chryssanthi Koutsandrea, Michael A Grentzelos, Dimitris Papaconstantinou
OBJECTIVE: To determine subtle changes of Heidelberg retina tomography (HRT) stereometric parameters and blue-on-yellow (B/Y) perimetry global indices for the early diagnosis of glaucoma in suspected subjects. PATIENTS AND METHODS: Cross-sectional data on 174 eyes of 87 subjects from a larger cohort, attending the Glaucoma Department of the "G. Gennimatas" General Hospital of Athens from January 2004 to February 2014, were used in the study. Subjects were assigned to 3 groups: (a) "normals" not requiring treatment throughout the study (group 1), (b) suspects who developed glaucoma and required treatment during the study (group 2), and (c) patients with incipient glaucoma (group 3)...
October 25, 2016: Journal of Glaucoma
Kyle G Reeves, Yi Yao, Yosuke Kanai
Recent technical advances in dealing with finite-size errors make quantum Monte Carlo methods quite appealing for treating extended systems in electronic structure calculations, especially when commonly used density functional theory (DFT) methods might not be satisfactory. We present a theoretical study of martensitic phase transition energetics of a two-dimensional phosphorene by employing diffusion Monte Carlo (DMC) approach. The DMC calculation supports DFT prediction of having a rather diffusive barrier that is characterized by having two transition states, in addition to confirming that the so-called black and blue phases of phosphorene are essentially degenerate...
September 28, 2016: Journal of Chemical Physics
V Beutner, S G Zhang, H Meyer, J Kłos
We present the first measurement of a bound-state spectrum of the NO-He complex. The recorded spectrum is associated with the first overtone transition of the NO moiety. The IR absorption is detected by exciting the vibrationally excited complex to the Ã-state dissociation continuum. The resulting NO(A) fragment is subsequently ionized in the same laser pulse. We recorded two bands centered around the NO monomer rotational lines, Q11(0.5) and R11(0.5), consistent with an almost free rotation of the NO fragment within the complex...
September 28, 2016: Journal of Chemical Physics
Moussa Gueye, Julien Nillon, Olivier Crégut, Jérémie Léonard
We describe a broadband transient absorption (TA) spectrometer devised to excite and probe, in the blue to UV range, vibrational coherence dynamics in organic molecules in condensed phase. A 800-nm Ti:Sa amplifier and a hollow fiber compressor are used to generate a 6-fs short pulse at 1 kHz. Broadband sum frequency generation with the fundamental pulse is implemented to produce a 400-nm, 8-fs Fourier limited short pulse. A UV-Vis white-light supercontinuum is implemented as a probe with intensity self-referencing to achieve a shot-noise-limited sensitivity...
September 2016: Review of Scientific Instruments
David K A Barnes
Climate-forced ice losses are increasing potential for iceberg-seabed collisions, termed ice scour. At Ryder Bay, West Antarctic Peninsula (WAP) sea ice, oceanography, phytoplankton and encrusting zoobenthos have been monitored since 1998. In 2003, grids of seabed markers, covering 225 m(2) , were established, surveyed and replaced annually to measure ice scour frequency. Disturbance history has been recorded for each m(2) of seabed monitored at 5-25 m for ~13 years. Encrusting fauna, collected from impacted and nonimpacted metres each year, show coincident benthos responses in growth, mortality and mass of benthic immobilized carbon...
October 26, 2016: Global Change Biology
Zhisong Lu, Jing Wang, Rui Li, Yan Qiao, Mengyao Zhou, Chang Ming Li
In the past few decades, tremendous effort has been dedicated to develop bacteriorhodopsin (bR)-based photo-electronic devices for generating a stationary photocurrent and further for use as a component of artificial retinas in constant illumination sensing. However, an IR-triggered stationary photocurrent with controllable amplitudes has never been realized to date. Herein, NaYF4:Yb,Er and NaYF4:Yb,Tm upconversion nanoparticles (UCNPs) with green and blue emissions, respectively, were synthesized and further incorporated with bR to build a bionanosystem...
October 26, 2016: Nanoscale
Kun-Lin Ho, Lo-Yun Lee, Marusu Katada, Asuka Fujii, Jer-Lai Kuo
Fermi resonance between the N-H stretching (ν1 and ν3) and the overtone of N-H bending (2ν4) in ammonia has hindered the interpretation and assignments of experimental spectra of small ammonia clusters. In this work, we carried out anharmonic vibrational calculations using MP2/aug-cc-pVDZ to examine the vibrational spectra of (NH3)n=1-5 with a focus on the size evolution. The enhancement of hydrogen bond strength due to cooperative effects will cause ν1 and ν4 to red-shift and blue-shift, respectively, when the size of the cluster increases...
October 26, 2016: Physical Chemistry Chemical Physics: PCCP
Iam Choon Khoo, Chun-Wei Chen, Tsung-Jui Ho
In this paper, we show that photosensitive azo-dye doped Blue-phase liquid crystals (BPLC) formed by natural molecular self-assembly are capable of high diffraction efficiency holographic recording with memory that can be prolonged from few seconds to several minutes by uniform illumination with the reference beam. Operating in the Bragg regime, we have observed 50 times improvement in the grating diffraction efficiency and shorter recording time compared to previous investigations. The enabling mechanism is BPLC's lattice distortion and index modulation caused by the action of light on the azo-dopant; upon photo-excitation, the azo-molecules undergo transformation from the oblong-shaped Trans-state to the bent-shaped Cis-state, imparting disorder and also cause the surrounding BPLC molecules to undergo coupled flow &reorientation leading to lattice distortion and index modulation...
October 26, 2016: Scientific Reports
Saket Kumar Singh, Bibhas Kumar Bhunia, Nandana Bhardwaj, Sween Gilotra, Biman B Mandal
Tunable repeated drug administration is often inevitable in number of pathological cases. Reloadable 3D matrices for sustained drug delivery are predicted as a prospective avenue to realize this objective. This study was directed towards sonication-induced fabrication of novel reloadable Bombyx mori silk fibroin (SF) (4, 6 and 8 wt%) hydrogel, injected within 3D porous (8 wt%) scaffolds. The focus was to develop a dual-barrier reloadable depot system for sustained molecular cargo-release. Both the varying SF concentration (4, 6 and 8 wt%) and the sonication time (30, 45 and 60 s) dictated the extent of cross-linking, β-sheet content and porosity (1-10 µm) influencing the release behavior of model molecules...
October 26, 2016: Molecular Pharmaceutics
Lakshini H S Mendis, Angus C Grey, Richard L M Faull, Maurice A Curtis
INTRODUCTION: Alzheimer's disease (AD), the leading cause of dementia, is pathologically characterized by β-amyloid plaques and tau tangles. However, there is also evidence of lipid dyshomeostasis-mediated AD pathology. Given the structural diversity of lipids, mass spectrometry is a useful tool for studying lipid changes in AD. Although there have been a few studies investigating lipid changes in the human hippocampus in particular, there are few reports on how lipids change in each hippocampal subfield (e...
October 2016: Brain and Behavior
Ying Chen, Shuyan Cao, Pingping Xu, Wei Han, Tiankai Shan, Jingying Pan, Weiwei Lin, Xue Chen, Xiaodong Wang
BACKGROUND Results from DNA microarray experiments have shown that the expression of miR-34s undergoes significant changes following spinal cord injury (SCI). The present study was designed to detect changes in the expression of miR-34s and its target genes during the acute and sub-acute stages of SCI. MATERIAL AND METHODS Luxol fast blue (LFB) staining for myelin was used to observe the differences in the general morphology of the spinal cord after SCI in a contusion model in rats. qPCR was carried out to determine the expression variation of miR-34s and its target genes during the acute and sub-acute stages of SCI...
October 25, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Neena Prasad, Karthikeyan Balasubramanian
We report, the enhanced photocatalytic behaviour of Cu doped ZnS micro crystals. ZnS and different concentrations of Cu doped ZnS microcrystals were prepared. X-ray diffraction confirms the crystalline and phase of the particles. Morphology and sizes were studied using Scanning Electron Microscopy (SEM). Recorded optical absorption spectra show a band for around 365nm for pure ZnS, but there is a broad band in the near infrared regime for the Cu-doped ZnS microcrystals which are attributed to the d-d transitions of Cu(2+) ions...
October 17, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Zaiddodine Pashandi, Maryam Molakarimi, Reza H Sajedi, Majid Taghdir, Hossein Naderi-Manesh
Mnemiopsin, an EF-hand Ca(2+) binding photoprotein isolated from luminous ctenophore Mnemiopsis leidyi, emits blue light from its chromophore, coelenterazine, which is non-covalently bond in its central hydrophobic core. Previous studies have revealed unique biochemical properties for ctenophore photoproteins such as inactivation by light, but only few have focused on photoinactivation process. To understand the nature of photoinactivation process we have investigated the impact of light alone and in the presence of Ca(2+) ion on the structure of this photoprotein...
October 18, 2016: Journal of Photochemistry and Photobiology. B, Biology
Robert T Dauchy, Melissa A Wren-Dail, Aaron E Hoffman, John P Hanifin, Benjamin Warfield, George C Brainard, Steven M Hill, Victoria P Belancio, Erin M Dauchy, David E Blask
Regular cycles of exposure to light and dark control pineal melatonin production and temporally coordinate circadian rhythms of metabolism and physiology in mammals. Previously we demonstrated that the peak circadian amplitude of nocturnal blood melatonin levels of rats were more than 6-fold higher after exposure to cool white fluorescent (CWF) light through blue-tinted (compared with clear) rodent cages. Here, we evaluated the effects of light-phase exposure of rats to white light-emitting diodes (LED), which emit light rich in the blue-appearing portion of the visible spectrum (465-485 nm), compared with standard broadspectrum CWF light, on melatonin levels during the subsequent dark phase and on plasma measures of metabolism and physiology...
2016: Comparative Medicine
Otmar M Ten Kate, Rong-Jun Xie, Chun-Yun Wang, Shiro Funahashi, Naoto Hirosaki
Novel Sr2-yEuyB2-2xSi2+3xAl2-xN8+x phosphors were investigated as a function of the boron and aluminum over silicon ratio and as a function of the Eu(2+) concentration. Samples were prepared via solid-state reaction synthesis by carefully controlling the synthesis conditions and composition. At high boron and aluminum content, that is, x = 0, a Eu(2+) 5d-4f emission is observed of which the maximum shifts from 595 nm for low Eu concentrations (y = 0.005) toward 623 nm for high Eu concentrations (y = 0.5). The samples can be excited by UV or blue light up to ∼475 nm...
October 25, 2016: Inorganic Chemistry
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