Stanley Fayn, A Paden King, Nicholas T Gutsche, Zhijian Duan, Jesse Buffington, Colleen P Olkowski, Ying Fu, Jessica Hong, Deepak Sail, Kwamena E Baidoo, Rolf E Swenson, Ross W Cheloha, Mitchell Ho, Peter Choyke, Freddy Escorcia
Primary liver cancer is the third leading cause of cancer-related deaths, and its incidence and mortality are increasing worldwide. Hepatocellular carcinoma (HCC) accounts for 80% of primary liver cancer cases. Glypican-3 (GPC3) is a heparan sulfate proteoglycan that histopathologically defines HCC and represents an attractive tumor-selective marker for radiopharmaceutical imaging and therapy for this disease. Single-domain antibodies are a promising scaffold for imaging because of their favorable pharmacokinetic properties, good tumor penetration, and renal clearance...
March 30, 2023: Journal of Nuclear Medicine