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Pierre Hennebert, Ismahen Samaali, Pauline Molina
A stepwise method for assessment of the HP 12 is proposed and tested with 49 waste samples. The hazard property HP 12 is defined as "Release of an acute toxic gas": waste which releases acute toxic gases (Acute Tox. 1, 2 or 3) in contact with water or an acid. When a waste contains a substance assigned to one of the following supplemental hazards EUH029, EUH031 and EUH032, it shall be classified as hazardous by HP 12 according to test methods or guidelines (EC, 2014a, 2014b). When the substances with the cited hazard statement codes react with water or an acid, they can release HCl, Cl2, HF, HCN, PH3, H2S, SO2 (and two other gases very unlikely to be emitted, hydrazoic acid HN3 and selenium oxide SeO2 - a solid with low vapor pressure)...
September 26, 2016: Waste Management
Minsu Kwon, Hyejin Jang, Eun Hye Kim, Jong-Lyel Roh
Poly (ADP-ribose) polymerase (PARP) is a key molecule in the DNA damage response (DDR), which is a major target of both chemotherapies and radiotherapies. PARP inhibitors therefore comprise a promising class of anticancer therapeutics. In this study, we evaluated the efficacy of the PARP inhibitor olaparib, and also sought to identify the mechanism and predictive marker associated with olaparib sensitivity in head and neck cancer (HNC) cells. A total of 15 HNC cell lines, including AMC HNC cells, were tested...
September 29, 2016: Cell Cycle
Bryan D Fleming, Mitchell Ho
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, yet no effective therapeutics exist. This review provides an overview of the recent development of recombinant immunotoxins for the treatment of glypican-3 (GPC3) expressing HCC. GPC3 is a cell surface heparan sulfate proteoglycan that is overexpressed in HCC, but is absent from normal adult human tissues. Treatment of HCC with anti-GPC3 immunotoxins represents a new therapeutic option. Using phage display and hybridoma technologies, three high affinity antibodies (HN3, HS20 and YP7) have been generated against GPC3...
2016: Toxins
Liqin Ye, Chunxiang Yang, Weidong Li, Jiangbo Hao, Meng Sun, Jingru Zhang, Zhongshuang Zhang
The types and amounts of volatiles in denucleated fruit of 30 Chinese dwarf cherry germplasms were determined by headspace solid-phase microextraction and gas chromatography-mass spectrometry to assess the genotypic variation. Eighty-five volatiles were identified; hexyl acetate, 4-penten-1-yl acetate, prenyl acetate, (Z)-pent-2-enyl hexanoate, geranyl acetate, n-butyl acetate, (3Z)-3,7-dimethylocta-1,3,6-triene, geraniol, pent-2-enyl butanoate, ethyl caprylate, butyl hexanoate, and linalool were the main volatiles...
February 15, 2017: Food Chemistry
Chiho Lee, Hyewon Son, Sungnam Park
Hydrogen bonds (H-bonds) play an important role in determining the structures and dynamics of molecular systems. In this work, we investigated the effect of H-bonds on the vibrational population relaxation and orientational relaxation dynamics of HN3 and N3(-) in methanol (CH3OH) and N,N-dimethyl sulfoxide (DMSO) using polarization-controlled infrared pump-probe spectroscopy and quantum chemical calculations. Our detailed analysis of experimental and computational results reveals that both vibrational population relaxation and orientational relaxation dynamics of HN3 and N3(-) in CH3OH and DMSO are substantially dependent on the strength of the H-bonds between the probing solute and its surrounding solvent...
September 15, 2016: Journal of Physical Chemistry. B
Chunguang Wang, Wei Gao, Mingqian Feng, Ira Pastan, Mitchell Ho
Glypican-3 (GPC3) is overexpressed in hepatocellular carcinoma (HCC). We constructed a recombinant immunotoxin, HN3-mPE24, which contains a truncated form of Pseudomonas exotoxin A. The toxin portion lacks most of domain II and has seven point mutations in domain III to remove the B-cell epitopes thought to be responsible for causing off-target side effects and immunogenicity. We also fused a bivalent HN3 to mPE24. We tested these two molecules for GPC3 binding and cytotoxicity in HCC cell models. The KD values of HN3-mPE24 and HN3-HN3-mPE24 for GPC3-expressing tumor cells were 12 nM and 1...
July 13, 2016: Oncotarget
Yuxiu Sun, Hong Zhao, Yongming Ye, Wenbin Nie, Wenjing Bai, Jia Liu, Sinuo Li, Fang Wang, Mingjuan Han, Liyun He
BACKGROUND: Many previous studies have shown the potential therapeutic effect of acupuncture for allergic rhinitis. Most of these studies, however, were limited by the short duration of observations and lack of sham acupuncture as the control group. Our preliminary experiments showed that the use of a warm needling achieved a much more persistent effect in the treatment of allergic rhinitis (AR) compared with simple acupuncture therapy. Hence, we have designed a multicenter, randomized controlled trial (RCT) in which the first-line medication loratadine will be used as the control group, and the effect of warm needling therapy will be evaluated through long-term observation...
2016: Trials
Hui-jie Yu, Xiao-qin Xu, Song-ao Xu, Xu Jun, Wei-zhong Cao
OBJECTIVE: To observe analgesic and sedative effect of acupuncture combined with medicine (ACM) on patients undergiong cardiac surgery. METHODS: A total of 50 patients with cardiac surgery from January 2012 to October 2014 were randomly assigned to the conventional analgesia group (group A) and the ACM analgesia group (group B), 25 in each group. Patients in group A were subjected to analgesia and sedation by injecting dexmedetomidine, while patients in group B were subjected to analgesia and sedation by electro-acupuncture [EA, Shenting (GV24); Yintang (EX-HN3)] combined with injection of dexmedetomidine...
March 2016: Chinese Journal of Integrated Traditional and Western Medicine
Jun Yuan, Yu Wu, Ji-yong Li, Xi Chen, Li Zhang, Yu-feng Liu, Sheng-xiong Tong, Fang-fang Deng
OBJECTIVE: To explore the effect of dexmedetomidine combined electrical stimulation on cognitive function of neurosurgical diseases patients treated by extracerebral intervention. METHODS: Totally 122 patients with neurosurgical diseases who underwent selective intervention were randomly assigned to the observation group and the control group, 61 cases in each group. Patients in the control group recieved anesthesia by dexmedetomidine. Those in the observation group received electrical stimulation at Baihui (DU20), Yintang ( EX-HN3), and Neiguan (PC6) before dexmedetomidine anesthesia...
March 2016: Chinese Journal of Integrated Traditional and Western Medicine
Guang-Rui Qian, Haiyang Niu, Chao-Hao Hu, Artem R Oganov, Qingfeng Zeng, Huai-Ying Zhou
Nitrogen hydrides, e.g., ammonia (NH3), hydrazine (N2H4) and hydrazoic acid (HN3), are compounds of great fundamental and applied importance. Their high-pressure behavior is important because of their abundance in giant planets and because of the hopes of discovering high-energy-density materials. Here, we have performed a systematic investigation on the structural stability of N-H system in a pressure range up to 800 GPa through evolutionary structure prediction. Surprisingly, we found that high pressure stabilizes a series of previously unreported compounds with peculiar structural and electronic properties, such as the N4H, N3H, N2H and NH phases composed of nitrogen backbones, the N9H4 phase containing two-dimensional metallic nitrogen planes and novel N8H, NH2, N3H7, NH4 and NH5 molecular phases...
2016: Scientific Reports
Carlos G Fraga, Krys Bronk, Brian P Dockendorff, Alejandro Heredia-Langner
Chemical attribution signatures (CAS) are being investigated for the sourcing of chemical warfare (CW) agents and their starting materials that may be implicated in chemical attacks or CW proliferation. The work reported here demonstrates for the first time trace impurities from the synthesis of tris(2-chloroethyl)amine (HN3) that point to the reagent and the specific reagent stocks used in the synthesis of this CW agent. Thirty batches of HN3 were synthesized using different combinations of commercial stocks of triethanolamine (TEA), thionyl chloride, chloroform, and acetone...
May 17, 2016: Analytical Chemistry
Genghao Gong, Hiroki Nagasawa, Masakoto Kanezashi, Toshinori Tsuru
A promising layered-hybrid membrane consisting of a microporous organosilica active layer deposited onto a porous polymer support was prepared via a facile sol-gel spin-coating process. Subsequently, the pore sizes and structures of the organosilica top layers on the membrane surface were tuned at mild temperature combined with vapor treatment from either hydrochloric acid (HVT) or ammonia (AVT), thereby tailoring the desalination performance of the membranes during reverse osmosis (RO) processing. The effects of HVT and AVT on the pore size, structure, and morphology of organosilica layers and on the separation performances of membranes were investigated in detail...
May 4, 2016: ACS Applied Materials & Interfaces
Seung Ho Baek, Jeong-Hyeon Ko, Hanwool Lee, Jinhong Jung, Moonkyoo Kong, Jung-woo Lee, Junhee Lee, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Seok-Geun Lee, Bum Sang Shim, Gautam Sethi, Sung-Hoon Kim, Woong Mo Yang, Jae-Young Um, Kwang Seok Ahn
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is persistently activated in squamous cell carcinoma of the head and neck (SCCHN) and can cause uncontrolled cellular proliferation and division. HYPOTHESIS: Thus, its targeted abrogation could be an effective strategy to reduce the risk of SCCHN. Resveratrol is known for its anti-cancer efficacy in a variety of cancer models. STUDY DESIGN: The effect resveratrol on STAT3 activation, associated protein kinases, phosphatases, cellular proliferation and apoptosis was investigated...
May 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Nobuyuki Tanahashi, Ken Takagi, Nozomi Amagasu, Guifeng Wang, Kaito Mizuno, Jun Kawanoguchi, Guo Yi, Torao Ishida
Depression is a kind of mood disorder. The incidence of depressed patients has demonstrated an upward trend in recent years. Symptoms may improve with treatments such as pharmacotherapy and cognitive-behavioral therapy, but such approaches may exert strong side effects, and therapeutic effects can be slow. We studied how acupuncture stimulation would affect depression as a method to reduce side effects. Mild depression was induced in rats by 1-week water-immersion stress. We treated these mildly depressed rats with either acupuncture stimulation at the "Bai-Hui" (GV 20) and "Yintáng" (Ex-HN3) points, or antidepressants...
April 8, 2016: Neuroscience Letters
Jun-hua Mei, Jun-il Wang, Li-jun Luo, Guo-hua Chen, Zhong-wen Zhang, Xiao-feng Pan, Dan Wei, Wei Shao
OBJECTIVE: To observe the effects of acupuncture on neurofunction and neuropsychological factors of chronic alcoholic peripheral neuropathy (CAPN) patients. METHODS: Totally 120 CAPN patients were assigned to the common treatment group, acupuncture group A, and acupuncture group B according to random digit table, 40 in each group. All patients recieved conventional drug therapy. Besides, patients in the acupuncture group A were additionally needled at Pishu (BL20), Weishu (BL21), Xuehai (SP10), Yinlingquan (SP9), Zusanli (ST36), Yanglingquan (GB34), Jiexi (ST41), Xuanzhong (GB39), Xiangu (ST43),Taixi (KI3), Quchi (LI11), Waiguan (SJ5), Hegu (LI4), and so on...
December 2015: Chinese Journal of Integrated Traditional and Western Medicine
Bok-Soon Lee, Haeng-Jun Kim, Jae-Woong Hwang, Kwang Ho Cheong, Kyung-Ah Kim, Hyun-Young Cha, Ji Min Lee, Chul-Ho Kim
PURPOSE: It has been reported that the abnormal activation of receptor tyrosine kinases is associated with the development of many human carcinomas and the high activation of EGFR and Met mediates the tumorigenicity of laryngeal carcinoma. In this study, we have done the therapeutic efficacy of ME22S (a novel EGFR/Met bispecific antibody) in laryngeal carcinoma in vitro and in vivo was thoroughly evaluated. METHODS: The effects of ME22S on cell viability was assessed through MTT assays, and then Western blotting and immunocytochemistry were used to determine the expression of EGFR and Met...
June 2016: Annals of Surgical Oncology
Xiao-ming Wan, Ying-ru Liu, Mei Lei, Ze-chun Huang, Tong-bin Chen
Synchrotron radiation X-ray absorption near edge structure was employed to study the arsenic (As) speciation in 13 Pteris vittata L. populations collected from 7 provinces, cities, and autonomous regions in China. As in roots of P. vittata was mainly combined with oxygen (O), with a small amount of As combined with glutathione (GSH). Populations from Hunan and Guangxi provinces showed higher percentages of As-GSH in soots. As in roots of P. vittata was predominated with As(V), with the percentage of As(V) to the total As being 59...
August 2015: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Deniz Tuna, Wolfgang Domcke
8-Oxoguanine is the most abundant oxidation product found in oxidatively damaged DNA. The study of the excited-state properties of the corresponding deoxyribonucleoside 8-oxo-deoxyguanosine is thus of important biological relevance. Herein, we present an ADC(2)-s ab initio study of the neutral and the anionic form of 8-oxo-deoxyguanosine, for each of which we have considered the intramolecularly 5'-O-H···N3 hydrogen-bonded syn conformer. We present energy profiles for a radiationless deactivation mechanism via intramolecular excited-state proton transfer...
January 14, 2016: Physical Chemistry Chemical Physics: PCCP
Min Hou, Jun-Fan Xie, Xiang-Pan Kong, Yi Zhang, Yu-Feng Shao, Can Wang, Wen-Ting Ren, Guang-Fu Cui, Le Xin, Yi-Ping Hou
Onabotulinumtoxin A (BoNTA) has been reported to be effective in the therapy for migraines. Acupuncture has been used worldwide for the treatment of migraine attacks. Injection of a small amount of drug at acupuncture points is an innovation as compared to traditional acupuncture. The purpose of this study was to evaluate and compare the effectiveness of fixed (muscle)-site and acupoint-site injections of BoNTA for migraine therapy in a randomized, double-blinded, placebo-controlled clinical trial extending over four months...
November 2015: Toxins
Brent K Amberger, Brian J Esselman, John F Stanton, R Claude Woods, Robert J McMahon
The millimeter-wave spectrum of hydrazoic acid (HN3) was analyzed in the frequency region of 235-450 GHz. Transitions from a total of 14 isotopologues were observed and fit using the A-reduced or S-reduced Hamiltonian. Coupled-cluster calculations were performed to obtain a theoretical geometry, as well as rotation-vibration interaction corrections. These calculated vibration-rotation correction terms were applied to the experimental rotational constants to obtain mixed theoretical/experimental equilibrium rotational constants (Ae, Be, and Ce)...
September 14, 2015: Journal of Chemical Physics
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