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https://www.readbyqxmd.com/read/28504960/distinct-effects-of-rs895819-on-risk-of-different-cancers-an-update-meta-analysis
#1
Muxiong Chen, Wenpan Fang, Xinkai Wu, Suchen Bian, Guangdi Chen, Liqin Lu, Yu Weng
Previous studies have indicated an association between the genetic variant in pre-miR-27a rs895819 with A->G transition and cancer risk; however, the results remain inconsistent and somehow conflicting in different cancers. Therefore, to obtain a more reliable conclusion, we performed an update meta-analysis by searching PubMed database or other databases. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to evaluate cancer risk. A total of 34 case-control studies involving 15,388 cases and 18,704 controls were included...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28502334/ap-1-expression-and-its-clinical-relevance-in-immune-disorders-and-cancer
#2
REVIEW
Shivtia Trop-Steinberg, Yehudit Azar
The inflammatory response is known to have a significant role in certain autoimmune diseases and malignancies. We review current knowledge regarding the functions of activator protein 1 (AP-1) as an important modulator in several immune disorders and carcinomas. AP-1 is overexpressed in rheumatoid arthritis and in long-term allogeneic hematopoietic stem cell transplantation survivors; however, decreased expression of AP-1 has been observed in psoriasis, systematic lupus erythematosus and in patients who do not survive after hematopoietic stem cell transplantation...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28498444/high-expression-of-pftk1-in-cancer-cells-predicts-poor-prognosis-in-colorectal-cancer
#3
Youjun Mao, Yuqing Jia, Huijun Zhu, Wei Wang, Qin Jin, Fang Huang, Shu Zhang, Xiaoqiang Li
The serine/threonine-protein kinase PFTAIRE 1 (PFTK1) is a member of the cyclin‑dependent kinase family that is highly expressed in several malignant tumors, including hepatocellular carcinoma, esophageal, breast and gastric cancers, and glioma. It contributes to tumor progression and influences tumor prognosis. However, the expression and clinicopathological significance of PFTK1 in human colorectal cancer (CRC) remain to be elucidated. The present study aimed to examine the expression of PFTK1 and to evaluate the clinical significance of its expression in human CRC...
May 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28481424/evaluating-hepatocellular-carcinoma-cell-lines-for-tumor-samples-using-within-sample-relative-expression-orderings-of-genes
#4
Lu Ao, You Guo, Xuekun Song, Qingzhou Guan, Weicheng Zheng, Jiahui Zhang, Haiyan Huang, Yi Zou, Zheng Guo, Xianlong Wang
BACKGROUND & AIMS: Concerns are raised about the representativeness of cell lines for tumors due to the culture environment and misidentification. Liver is a major metastatic destination of many cancers, which might further confuse the origin of hepatocellular carcinoma (HCC) cell lines. Therefore, it is of crucial importance to understand how well they can represent HCC. METHODS: The HCC-specific gene pairs with highly stable relative expression orderings (REOs) in more than 99% of HCC but with reversed REOs in at least 99% of one of the six types of cancer, colorectal carcinoma (CRC), breast carcinoma (BRC), non-small-cell lung cancer, gastric carcinoma, pancreatic carcinoma and ovarian carcinoma, were identified...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28454301/immunohistochemical-profile-of-ing3-protein-in-normal-and-cancerous-tissues
#5
Wen-Feng Gou, Xue-Feng Yang, Dao-Fu Shen, Shuang Zhao, Hong-Zhi Sun, Jun-Sheng Luo, Hua-Chuan Zheng
The inhibitor of growth family, member 3 (ING3) protein may be capable of blocking the cell cycle via activating p53-transactivated promoters of p21 and Bcl2-associated X protein, and may induce apoptosis via a Fas/caspase-8-dependent signaling pathway. In the present study, immunohistochemistry was performed in order to characterize the expression profile of ING3 protein in tissue microarrays containing mouse and human normal tissue, human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung carcinoma (n=192)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28443573/the-normal-and-tumour-tissue-mrna-expressions-of-telomerase-complex-genes-in-several-types-of-cancer
#6
Emel Çalışkan Can, M Can Atalay, Ece Miser Salihoğlu, Ülkü Yalçıntaş Arslan, H Bolkan Şimşek, Sevgi Yardım Akaydın
AIMS: The aim of this study is to investigate the changes in mRNA expression levels of telomerase related significant proteins in several types of cancer. METHODS: Human telomerase reverse transcriptase (hTERT), pontin, reptin and dyskerin expressions were measured in normal and tumour tissues obtained from 26 patients with colorectal, breast, and gastric cancers, using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method. RESULTS: For all the patients, no significant difference was found in mRNA expressions of hTERT and dyskerin (p>0...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28425822/association-of-hepatic-vein-lipiodol-tram-track-sign-during-transcatheter-arterial-chemoembolization-with-perioperative-death
#7
Hongwei Zhao, Fuquan Liu, Zhendong Yue, Lei Wang, Zhenhua Fan, Fuliang He
Objective To assess the relationship between the hepatic vein Lipiodol tram-track sign during transcatheter arterial chemoembolization (TACE) and perioperative death. Methods Patients treated for hepatic carcinoma at the Beijing Shijitan Hospital, Capital Medical University from January 2010 to December 2015 were retrospectively evaluated. The patients underwent hepatic TACE with Lipiodol. The incidence of the hepatic vein Lipiodol tram-track sign, prognosis, and possible risk factors were analyzed. Results A total of 5372 patients underwent hepatic TACE and had complete available intraoperative imaging data...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28415828/melatonin-for-the-prevention-and-treatment-of-cancer
#8
REVIEW
Ya Li, Sha Li, Yue Zhou, Xiao Meng, Jiao-Jiao Zhang, Dong-Ping Xu, Hua-Bin Li
The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experimental studies have documented that melatonin could exert growth inhibition on some human tumor cells in vitro and in animal models. The underlying mechanisms include antioxidant activity, modulation of melatonin receptors MT1 and MT2, stimulation of apoptosis, regulation of pro-survival signaling and tumor metabolism, inhibition on angiogenesis, metastasis, and induction of epigenetic alteration...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413641/serum-mir-20a-is-a-promising-biomarker-for-gastric-cancer
#9
Ruirui Yang, Yun Fu, Ying Zeng, Mengqin Xiang, Yufang Yin, Li Li, Haifan Xu, Jing Zhong, Xi Zeng
Gastric cancer (GC) is a common type of cancer, particularly in China. Numerous studies have demonstrated that circulating microRNAs (miRNAs) have potential applications as noninvasive biomarkers for cancer diagnosis and prognosis. Microarray-based serum miRNA profiling was performed on the serum of 12 paired pre- and post-operative GC patients to screen differentially expressed serum miRNAs. Twelve different serum miRNAs between pre- and post-operative GC patients were identified. Those miRNAs were verified by real-time quantitative polymerase chain reaction in 110 paired pre- and post-operative serum samples from 55 GC patients...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28373448/defining-new-colorectal-cancer-syndromes-in-a-population-based-cohort-of-the-disease
#10
Anna Forsberg, Anne Keränen, Susanna VON Holst, Simone Picelli, Nikos Papadogiannakis, Sam Ghazi, Annika Lindblom
BACKGROUND/AIM: Most known cancer syndromes confer an increased risk of more than one tumour types, and families with more than one colorectal cancer often segregate other cancers as well. The aim of this study was to examine if there is a general increased risk of other cancers in colorectal cancer families, which are defined as having two or more cases of colorectal cancer in close relatives. MATERIALS AND METHODS: The study used a detailed family history of cancer diagnoses in a cohort of more than 3,000 consecutive colorectal cancer cases...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28363756/her2-as-an-emerging-oncotarget-for-colorectal-cancer-treatment-after-failure-of-anti-epidermal-growth-factor-receptor-therapy
#11
REVIEW
Naoki Takegawa, Kimio Yonesaka
Amplification of the HER2 gene is an indicator of poor prognosis for several kinds of malignancies such as breast and gastric cancer, and anti-HER2 targeting therapies provide clinical benefits in these patients. In 2011, HER2 was identified as a resistance molecule for de novo and secondary anti-epidermal growth factor receptor (EGFR) antibody therapy. HER2 activation provides a bypass signaling pathway after anti-EGFR antibody treatment of colorectal cancer. Cell line-based screening revealed that HER2 genomic amplification induces resistance to the anti-EGFR antibody cetuximab in colorectal cancer...
March 9, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28352193/cdkl1-promotes-tumor-proliferation-and-invasion-in-colorectal-cancer
#12
Chunzhi Qin, Li Ren, Meiling Ji, Shixu Lv, Ye Wei, Dexiang Zhu, Qi Lin, Pingping Xu, Wenju Chang, Jianmin Xu
BACKGROUND: CDKL1 is a member of the cell division cycle 2 (CDC2)-related serine threonine protein kinase family and is overexpressed in malignant tumors such as melanoma, breast cancer, and gastric cancer. OBJECTIVE: This study aimed to evaluate whether CDKL1 can serve as a potential molecular target for colorectal cancer therapy. MATERIALS AND METHODS: Expression of CDKL1 in colorectal cancer tissues and cell lines was measured by immunohistochemistry and Western blot, respectively...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28351315/obesity-associated-digestive-cancers-a-review-of-mechanisms-and-interventions
#13
REVIEW
Jiachen Zheng, Ming Zhao, Jiahui Li, Guoying Lou, Yanyan Yuan, Shizhong Bu, Yang Xi
The prevalence of obesity has steadily increased over the past few decades. Previous studies suggest that obesity is an oncogenic factor and that over 20% of all cancers are obesity-related. Among such cancers, digestive system malignancies (including esophageal adenocarcinomas, colorectal cancers, and cancers of the gastric cardia, liver, and pancreas) are reported most frequently. While the 5-year survival rates of cancers of the breast and prostate are 90%, that rate is only 45% for digestive cancers. In this review, the mechanisms of obesity-associated digestive cancers are discussed, with an emphasis on obesity-related gene mutations, insulin and insulin-like growth factor signaling pathways, chronic inflammation, and altered adipokine levels...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28266708/role-of-wnt-%C3%AE-catenin-signaling-regulatory-micrornas-in-the-pathogenesis-of-colorectal-cancer
#14
REVIEW
Farzad Rahmani, Amir Avan, Seyed Isaac Hashemy, Seyed Mahdi Hassanian
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling...
March 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28266163/quality-evaluation-of-investigator-initiated-trials-using-post-approval-cancer-drugs-in-japan
#15
Shunsuke Kondo, Hiroko Hosoi, Jun Hashimoto
Investigator-initiated trials (IITs) are important aspects of medical research and have contributed substantially to modern oncology. IITs using post-approval drugs have been conducted by domestic institutions in Japan. Data from this study were obtained by all IITs registered clinical trials for five cancers (lung, colorectal cancer, gastric cancer, liver cancer, and breast cancer) using drugs approved from 1999 to 2009 in Japan. The Kaplan-Meier method, analysis of variance (ANOVA), and Kruskal-Wallis test were used to estimate time to enrolment completion (TTEC) and time to enrolment per patient (TTEP)...
March 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/28246088/adiposity-and-cancer-at-major-anatomical-sites-umbrella-review-of-the-literature
#16
REVIEW
Maria Kyrgiou, Ilkka Kalliala, Georgios Markozannes, Marc J Gunter, Evangelos Paraskevaidis, Hani Gabra, Pierre Martin-Hirsch, Konstantinos K Tsilidis
Objective To evaluate the strength and validity of the evidence for the association between adiposity and risk of developing or dying from cancer.Design Umbrella review of systematic reviews and meta-analyses.Data sources PubMed, Embase, Cochrane Database of Systematic Reviews, and manual screening of retrieved references.Eligibility criteria Systematic reviews or meta-analyses of observational studies that evaluated the association between indices of adiposity and risk of developing or dying from cancer...
February 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28245782/reactive-oxygen-and-nitrogen-species-in-carcinogenesis-implications-of-oxidative-stress-on-the-progression-and-development-of-several-cancer-types
#17
Joanna Kruk, Hassan Y Aboul-Enein
BACKGROUND: The body of evidence available from published literature during the past three decades indicates that reactive oxygen species and reactive nitrogen species can induce, promote and modulate carcinogenesis. OBJECTIVE: The purpose of this review was to present current status of knowledge on the possible role of oxidative/nitrosative stress in the development and progression of several human cancers. Moreover, we discuss briefly the formation and decomposition of oxygen and nitrogen species within cells and their physiological and damaging influences...
February 28, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28243543/development-and-validation-of-a-36-gene-sequencing-assay-for-hereditary-cancer-risk-assessment
#18
Valentina S Vysotskaia, Gregory J Hogan, Genevieve M Gould, Xin Wang, Alex D Robertson, Kevin R Haas, Mark R Theilmann, Lindsay Spurka, Peter V Grauman, Henry H Lai, Diana Jeon, Genevieve Haliburton, Matt Leggett, Clement S Chu, Kevin Iori, Jared R Maguire, Kaylene Ready, Eric A Evans, Hyunseok P Kang, Imran S Haque
The past two decades have brought many important advances in our understanding of the hereditary susceptibility to cancer. Numerous studies have provided convincing evidence that identification of germline mutations associated with hereditary cancer syndromes can lead to reductions in morbidity and mortality through targeted risk management options. Additionally, advances in gene sequencing technology now permit the development of multigene hereditary cancer testing panels. Here, we describe the 2016 revision of the Counsyl Inherited Cancer Screen for detecting single-nucleotide variants (SNVs), short insertions and deletions (indels), and copy number variants (CNVs) in 36 genes associated with an elevated risk for breast, ovarian, colorectal, gastric, endometrial, pancreatic, thyroid, prostate, melanoma, and neuroendocrine cancers...
2017: PeerJ
https://www.readbyqxmd.com/read/28238770/association-between-screen-detected-gallstone-disease-and-cancer-in-a-cohort-study
#19
Daniel Mønsted Shabanzadeh, Lars Tue Sørensen, Torben Jørgensen
BACKGROUND & AIMS: Knowledge of temporal associations between screen-detected gallstone disease and specific cancers is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy are associated with occurrence of gastrointestinal and nongastrointestinal cancers. METHODS: We performed a cohort study of 3 randomly selected groups from the general population of Copenhagen. Participants (N = 5928) were examined from 1982 through 1992 and underwent abdominal ultrasound examination to detect gallstone disease, but were not informed of their gallstone status...
February 24, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28236798/adherence-and-safety-study-in-patients-on-treatment-with-capecitabine
#20
Francisca Fernández-Ribeiro, Rosario Olivera-Fernández, Carlos Crespo-Diz
BACKGROUND: The introduction of oral antineoplastic agents in therapeutics has caused a change in the treatment strategy against cancer. The objective of this study was to analyze the adherence in patients to treatment with capecitabine, their adverse events, and the overall health status of patients, as well as the relationship of these factors with adherence. METHOD: An observational, prospective study at 7 months, in a cohort of patients on capecitabine treatment, including treatment initiations and continuations, regardless of diagnosis or indication...
March 1, 2017: Farmacia Hospitalaria
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