keyword
https://read.qxmd.com/read/38395195/immunologic-basis-for-development-of-keratoconjunctivitis-sicca-in-systemic-autoimmune-diseases-role-of-innate-immune-sensors
#21
JOURNAL ARTICLE
Michael E Stern, Argyrios N Theofilopoulos, Philipp Steven, Jerry Y Niederkorn, Robert Fox, Margarita Calonge, Christof Scheid, Stephen C Pflugfelder
The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, systemic sclerosis and lupus. As the most environmentally exposed mucosal surface of the body, the conjunctiva constantly responds to environmental challenges which are typically self limited, but when persistent and unresolved may provoke pathogenic innate and adaptive immune reactions...
February 21, 2024: Ocular Surface
https://read.qxmd.com/read/38391267/long-term-outcomes-of-keratoprosthesis-with-biological-haptic-a-review-of-25-years-of-single-center-surgeries
#22
JOURNAL ARTICLE
Maximilian P M Angerer, Julia M Weller, Friedrich E Kruse, Konrad Hille
PURPOSE: To study the outcome of eyes that underwent surgery for keratoprosthesis with a biological haptic, osteo-odonto-keratoprosthesis (OOKP) or tibia keratoprosthesis, by a single surgeon over a time span of more than 25 years. METHODS: One hundred thirty eyes that had received a keratoprosthesis with a biological haptic between 1994 and 2022 by a single surgeon were included in this retrospective analysis. Main outcome parameters were postoperative best corrected visual acuity, postoperative refractive error, postoperative complications, anatomical and functional survival of the prosthesis as well as comparison of subgroups of the 2 different types (OOKP n = 78; tibia keratoprosthesis n = 52) of keratoprostheses, and subgroup analysis of different indications for surgery...
February 23, 2024: Cornea
https://read.qxmd.com/read/38390381/xerophthalmia-secondary-to-bowel-malabsorption-after-roux-en-y-gastric-bypass
#23
José Arturo Oyervides-Alvarado, Schenny Murra-Anton, Ethel Guinto-Arcos, Laura Alejandra González-Dibildox, Nallely Ramos-Betancourt
INTRODUCTION: Vitamin A is a fat-soluble vitamin, obtained through diet. Vitamin A deficiency is the leading cause of preventable blindness in children in developing countries due to impaired intake (Phanachet et al. 2018). Nevertheless, it is uncommon in the developed world where malabsorption takes a prominent role. CASE DESCRIPTION: A fifty-one-year-old female presented complaining of foreign body sensation, pain, tearing, fluctuating visual acuity, nyctalopia, diarrhea, polyphagia and weight loss...
2024: GMS Ophthalmology Cases
https://read.qxmd.com/read/38390068/a-rare-coexistence-of-sarcoidosis-with-overlap-syndrome-and-sarcoidosis-with-primary-biliary-cholangitis-and-sjogren-s-syndrome-two-distinct-case-reports
#24
Marwa Bougacha, Hana Blibech, Bouchra Bouchabou, Raja Jouini, Imen Helal, Houda Snene, Donia Belkhir, Nadia Mehiri, Rim Ennaifer, Achraf Chedly, Nozha Ben Salah, Bechir Louzir
Sarcoidosis and the overlap syndrome of autoimmune hepatitis and primary biliary cholangitis (PBC) share common clinical, biological, and histological features. The simultaneous occurrence of these diseases have been reported in few cases and suggests that a common pathway which may contribute to granuloma formation in both conditions. We report the cases of two female patients having an association of sarcoidosis and inflammatory liver diseases. The first case is of a 61-year-old woman had been monitored for an overlap syndrome of PBC and autoimmune hepatitis (AIH)...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38389327/clinical-evaluation-of-tear-substitute-utility-after-anti-vegf-intravitreal-injection
#25
JOURNAL ARTICLE
Cagini Carlo, Maria Poddi, Stefano Mocini, Niccolò Boni, Francesco Damiani, Michele Apponi Battini, Giuseppe Mirabella, Mario Tataranno
PURPOSE: The purpose of this study is to evaluate the role of a polyethylene glycol 400 - propylene glycol - hydroxypropyl guar - hyaluronic acid eye drops in relieving the symptoms of dry eye syndrome after anti-VEGF intravitreal injection. METHODS: In this randomized, parallel-group study, patients were randomized to receive standard therapy alone or study eye drops plus standard therapy. Patients enrolled were older than 50 with exudative age-related macular degeneration, who have never had intravitreal injections, and without severe dry eye condition or severe ocular or systemic conditions...
February 22, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38389244/ocular-surface-changes-in-patients-who-have-undergone-head-and-neck-radiation-therapy
#26
JOURNAL ARTICLE
H Sujithra, Kannisha N Shah, R Anoop, Pushpaja K Ullattil, Gopal S Pillai, Greeshma C Ravindran, Jayesh Vazirani
PURPOSE: Dry eye syndrome (DES) is a familiar sequelae of radiation therapy (RT) for head and neck cancers (HNC). Ocular surface changes such as DES occur due to injury to the conjunctival epithelium, goblet cells, corneal surface, lacrimal glands, and meibomian glands. This study aimed at the evaluation and early detection of changes in ocular surface parameters in patients receiving RT for extraocular HNC. METHODS: Forty-two eyes of 21 patients undergoing HNC RT were evaluated...
February 23, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38389137/disease-duration-affects-the-clinical-phenotype-of-primary-sj%C3%A3-gren-syndrome-a-medical-records-review-study-of-952-cases
#27
JOURNAL ARTICLE
Yan Zhang, Jian-Ying Yang, Jia-Qi Chen, Jia-He Liao, Zi-Wei Huang, Tzu-Hua Wu, Qian He, Xin-Bo Yu, Qin Wang, Wei-Jiang Song, Jing Luo, Qing-Wen Tao
OBJECTIVES: To investigate the impact of disease duration on clinical phenotypes in Chinese patients with primary Sjögren syndrome (pSS) and examine the correlation between clinical phenotypes and onset age, age at diagnosis, and disease duration. METHODS: Data from 952 patients diagnosed with pSS in China between January 2013 and March 2022 were analyzed based on medical records. Patients were categorized into 3 groups based on disease duration: short (<5 years), moderate (≥5 and <10 years), and long (≥10 years) group...
February 23, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38386250/ocular-surface-changes-following-computer-use-in-post-lasik-patients
#28
JOURNAL ARTICLE
Cristian Talens-Estarelles, Clara Talens-Estarelles, Santiago García-Lázaro
PURPOSE: To assess the impact of computer use on the ocular surface of individuals after laser in situ keratomileusis (LASIK). METHODS: The dry eye symptoms and ocular surface of 18 post-LASIK young individuals and 18 controls were evaluated before and after performing a 30-min task on a computer without (Visit 1) and with (Visit 2) initial instillation of artificial tears. Symptoms were assessed using the Ocular Surface Disease Index (OSDI), Symptom Assessment in Dry Eye questionnaire version two (SANDE II) and Computer Vision Syndrome Questionnaire (CVS-Q)...
February 22, 2024: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://read.qxmd.com/read/38379013/modeling-dry-eye-with-an-air-liquid-interface-in-corneal-epithelium-on-a-chip
#29
JOURNAL ARTICLE
Rodi Kado Abdalkader, Romanas Chaleckis, Takuya Fujita, Ken-Ichiro Kamei
Dry eye syndrome (DES) is a complex ocular condition characterized by an unstable tear film and inadequate tear production, leading to tissue damage. Despite its common occurrence, there is currently no comprehensive in vitro model that accurately reproduce the cellular characteristics of DES. Here we modified a corneal epithelium-on-a-chip (CEpOC) model to recapitulate DES by subjecting HCE-T human corneal epithelial cells to an air-liquid (AL) interface stimulus. We then assessed the effects of AL stimulation both in the presence and absence of diclofenac (DCF), non-steroidal anti-inflammatory drug...
February 20, 2024: Scientific Reports
https://read.qxmd.com/read/38363334/evaluation-of-dry-eye-severity-and-ocular-surface-inflammation-in-patients-with-autoimmune-rheumatic-diseases
#30
JOURNAL ARTICLE
Yingyi Liu, Mengbo Wu, Yuerong Ren, Jianing Feng, Wen Shi, Huanmin Kang, Jing Tian, Yan He
PURPOSE: To evaluate dry eye severity and ocular surface inflammation in autoimmune rheumatic diseases (ARDs). METHODS: Seventy-nine patients with ARDs were enrolled, including 26 patients with rheumatoid arthritis (RA), 33 patients with systemic lupus erythematosus (SLE), and 20 patients with primary Sjögren's syndrome (pSS). All patients underwent ocular surface evaluations, including ocular surface symptoms, signs, conjunctival impression cytology, and tear multicytokine detection...
February 16, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38360611/the-effect-of-oenothera-biennis-evening-primrose-oil-on-inflammatory-diseases-a-systematic-review-of-clinical-trials
#31
JOURNAL ARTICLE
Melika Sharifi, Nasim Nourani, Sarvin Sanaie, Sanaz Hamedeyazdan
BACKGROUND: Evening primrose oil (EPO), extracted from the seeds of Oenothera biennis, has gained attention for its therapeutic effects in various inflammatory conditions. METHOD: We performed a systematic search in multiple databases and defined the inclusion criteria based on the following PICOs: P: Patients with a form of inflammatory condition, I: EPO, C: Placebo or other therapeutic interventions, O: changes in inflammatory markers or patients' symptoms; S: randomized controlled trials...
February 15, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38356865/exosomal-noncoding-rna-a-potential-therapy-for-retinal-vascular-diseases
#32
REVIEW
Jong-Ik Heo, Juhee Ryu
Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites. They are secreted by cells and play a regulatory role in various biological responses by mediating cell-to-cell communication. Moreover, exosomes are of interest in developing therapies for retinal vascular disorders because they can deliver various substances to cellular targets. According to recent research, exosomes can be used as a strategy for managing retinal vascular diseases, and they are being investigated for therapeutic purposes in eye conditions, including glaucoma, dry eye syndrome, retinal ischemia, diabetic retinopathy, and age-related macular degeneration...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38354719/comprehensive-ophthalmological-evaluation-in-atopic-dermatitis
#33
JOURNAL ARTICLE
Anais Valeille, Coralie Ouilhon, Fabien Subtil, Florence Hacard, Coline Jaulent, Fréderic Bérard, Jean-François Nicolas, Jean-Luc Fauquert, Audrey Nosbaum
BACKGROUND: Atopic dermatitis (AD), a chronic Type 2 inflammatory skin disease, is frequently associated with ocular surface diseases (OSD) which may appear or worsen under anti-Type 2-targeted treatments. However, the exact prevalence of OSD and the ophthalmology referral criteria remain ill-defined in AD patients before initiating such biotherapies. OBJECTIVE: We aimed to characterize the prevalence, the nature and the factors related to OSD development in AD that may justify an ophthalmological management...
February 14, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38350814/influence-of-serial-intravitreal-injections-on-measures-of-dry-eye-a-systemic-review-and-meta-analysis
#34
REVIEW
Meng Gao, Fei Xia, Ping Wang, ZhenHua Feng, XinXin Wang
PURPOSE: The aim of this study was to evaluate the long-term effects of serial intravitreal injections (IVI) on measures of dry eye. METHODS: The PubMed, EMBASE, and Cochrane databases were searched according to the PROSPERO protocol (CRD42023455727). Studies evaluating the influence of serial IVI on the ocular surface compared with untreated fellow eyes were included. The measures of dry eye after IVI were used as outcome variables. The results are presented as mean difference (MD) with a corresponding 95% confidence interval (CI)...
February 12, 2024: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://read.qxmd.com/read/38350094/rethinking-sj%C3%A3-gren-beyond-inflammation-considering-the-role-of-nerves-in-driving-disease-manifestations
#35
JOURNAL ARTICLE
Victor Sanchez, Noa Dobzinski, Robert Fox, Anat Galor
Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease characterized by destruction of mucosal glands resulting in dry eye and dry mouth. Ocular presentations can be heterogenous in SS with corneal nerves abnormalities that are structural, functional, or both. Some individuals present with corneal hyposensitivity, with a phenotype of decreased tear production and epithelial disruption. Others present with corneal hypersensitivity, with a phenotype of neuropathic pain including light sensitivity and pain out of proportion to signs of tear dysfunction...
February 7, 2024: Eye & Contact Lens
https://read.qxmd.com/read/38349301/dry-eye-syndrome-preferred-practice-pattern%C3%A2
#36
JOURNAL ARTICLE
Guillermo Amescua, Sumayya Ahmad, Albert Y Cheung, Daniel S Choi, Vishal Jhanji, Amy Lin, Shahzad I Mian, Michelle K Rhee, Elizabeth T Viriya, Francis S Mah, Divya M Varu
No abstract text is available yet for this article.
February 12, 2024: Ophthalmology
https://read.qxmd.com/read/38345108/the-conjunctival-microbiome-and-dry-eye-what-we-know-and-controversies
#37
JOURNAL ARTICLE
Kendrick C Shih, Louis Tong
Dry eye disease is a common multifactorial condition that may be idiopathic or associated with autoimmune conditions, such as Sjogren syndrome. Commensal microorganisms modify immune responses, so it is relevant to understand how they modify such immune-mediated diseases. Microbiota in the gut regulate inflammation in the eye, and conversely, severe inflammation of the ocular surface results in alteration of gut microbiome. The conjunctiva microbiome can be analyzed using 16S or shotgun metagenomics. The amount of microbial DNA in ocular surface mucosa relative to human DNA is limited compared with the case of the intestinal microbiome...
February 6, 2024: Eye & Contact Lens
https://read.qxmd.com/read/38345056/association-of-systemic-markers-of-inflammation-with-signs-and-symptoms-of-dry-eye-disease-and-sjogren-s-syndrome-in-the-dry-eye-assessment-and-management-dream%C3%A2-study
#38
JOURNAL ARTICLE
Marium H Hashemi, Julian L Ambrus, Abhay A Shukla, Di Zhu, Gui-Shuang Ying, Penny A Asbell
PURPOSE: To evaluate the possible role of systemic inflammation in dry eye disease (DED) via systemic inflammatory marker associations with DED signs and symptoms, and an analysis of a subgroup with Sjogren's Syndrome (SS). METHODS: Participant serums were analyzed using line immunoassays (LIAs) for the presence of antibodies against 34 systemic inflammatory markers. Using the 2012 American College of Rheumatology definition, the 481 participants were categorized into group 1 (SS; n  = 52), group 2 (autoimmune disease not including SS; n  = 66), or group 3 (control, i...
February 12, 2024: Current Eye Research
https://read.qxmd.com/read/38340608/identification-of-outcome-domains-in-primary-sj%C3%A3-gren-s-disease-a-scoping-review-by-the-omeract-sj%C3%A3-gren-disease-working-group
#39
JOURNAL ARTICLE
Yann Nguyen, Maxime Beydon, Nathan Foulquier, Rachael Gordon, Coralie Bouillot, Katherine M Hammitt, Simon J Bowman, Xavier Mariette, Sara S McCoy, Divi Cornec, Raphaèle Seror
OBJECTIVES: Sjögren's disease (SjD) is a heterogenous disease with a wide range of manifestations, ranging from symptoms of dryness, fatigue, and pain, to systemic involvement. Considerable advances have been made to evaluate systemic activity or patient-reported outcomes, but most of the instruments were not able to assess all domains of this multifaceted disease. The aim of this scoping review was to generate domains that have been assessed in randomized controlled trials, as the first phase of the Outcome Measures in Rheumatology (OMERACT) process of core domain set development...
April 2024: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/38337657/impact-of-dietary-nutrients-on-the-prevalence-of-dry-eye-syndrome-among-korean-women-aged-40-and-above-evidence-from-the-korea-national-health-and-nutrition-examination-survey
#40
JOURNAL ARTICLE
Jeong-Mee Kim, Yean-Jung Choi
This study aimed to assess the prevalence of dry eye syndrome among Korean women aged 40 and above and explore the correlation between the syndrome and daily dietary nutrient intake. We analyzed data from 92,888 female participants (mean age: 63.35 ± 8.86 years) from the 8th Korea National Health and Nutrition Examination Survey (KNHANES 2019). Dietary intake was evaluated using a personalized 24 h recall method for 21 nutrients, including macronutrients, macro- and micro-minerals, and both water- and fat-soluble vitamins...
January 26, 2024: Nutrients
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