Duy Anh Pham, Chang-Sheng Wang, Line Séguy, Hu Zhang, Sabrina Benbabaali, Jimmy Faivre, Sotcheadt Sim, Guojun Xie, Mateusz Olszewski, Jean-Michel Rabanel, Florina Moldovan, Krzysztof Matyjaszewski, Xavier Banquy
Bottlebrush polymers (BB) have emerged as compelling candidates for biosystems to face tribological challenges, including friction and wear. This study provides a comprehensive assessment of an engineered triblock BB polymer's affinity, cell toxicity, lubrication, and wear protection in both in vitro and in vivo settings, focusing on applications for conditions like osteoarthritis and dry eye syndrome. Results show that the designed polymer rapidly adheres to various surfaces (e.g., cartilage, eye, and contact lens), forming a robust, biocompatible layer for surface lubrication and protection...
March 29, 2024: Advanced Materials