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Dry Eye Syndrome

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https://www.readbyqxmd.com/read/29143779/regenerative-therapies-in-dry-eye-disease-from-growth-factors-to-cell-therapy
#1
REVIEW
Antonio J Villatoro, Viviana Fernández, Silvia Claros, Cristina Alcoholado, Manuel Cifuentes, Jesús Merayo-Lloves, José A Andrades, José Becerra
Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29134275/-blepharitis-component-of-dry-eye-syndrome
#2
REVIEW
C Auw-Hädrich, T Reinhard
This review contains a compilation of long-standing and more recent relevant information on chronic blepharitis, especially in the context of dry eye disease regarding epidemiology, symptoms, clinical findings and pathophysiology. Chronic blepharitis often represents the underlying cause of dry eye disease but remains undetected and untreated in many cases; however, it can be a result of (hypovolemic) dry eye disease and leads to sometimes severe corneal complications, which are illustrated by material from our own patient archives...
November 13, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29127143/satb1-conditional-knockout-results-in-sj%C3%A3-gren-s-syndrome-in-mice
#3
Yuriko Tanaka, Takehiko Sotome, Akiko Inoue, Takanori Mukozu, Taku Kuwabara, Tetuo Mikami, Terumi Kowhi-Shigematsu, Motonari Kondo
Sjögren's syndrome (SS) is an autoimmune disease in which exocrine tissues are affected by cellular and humoral immunity. As a result, the salivary and lacrimal glands of patients with SS are damaged, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Because experimental approaches to investigate SS pathogenesis in human patients are limited, development of a mouse model is indispensable for understanding the disease. In this study, we show that special AT-rich sequence binding protein-1 conditional knockout (SATB1cKO) mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop SS by 4 wk of age, soon after weaning...
November 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29123309/oral-dryness-and-sj%C3%A3-gren-s-an-update
#4
P J Shirlaw, A Khan
Oral dryness is a very common condition presenting to a general dental practitioner or hospital specialist. The most common cause of oral dryness is drug related, however, patients with Sjögren's syndrome, a multisystem autoimmune condition, may present to their dentist rather than their GP complaining of dry mouth and dry eyes. This update article explores the causes of oral dryness and how to manage it. The update on Sjögren's syndrome explains the latest relevant diagnostic criteria, presenting signs, symptoms, investigations and management principles...
November 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29123104/a-prospective-randomized-trial-of-two-mucin-secretogogues-for-the-treatment-of-dry-eye-syndrome-in-office-workers
#5
Jun Shimazaki, Den Seika, Masamichi Saga, Kazumi Fukagawa, Miki Sakata, Miki Iwasaki, Takashi Okano
The purpose of the study was to compare the two mucin secretogogues, diquafosol (DQS) and rebamipide (RBM), for the treatment of dry eye syndrome (DES) in office workers. Dry eye patients using computers for >4 h/day were randomly assigned treatment with either DQS or RBM. Main outcomes measures included changes in tear film break-up time (TBUT) and subjective symptoms assessed by the Dry Eye-Related Quality of Life Score (DEQS). The subjects had scheduled examinations at 0 and 4 weeks, and the examinations at 2 and 8 weeks were optional...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121140/complications-of-cosmetic-eye-whitening
#6
Ann Q Tran, Catherine Hoppener, Nandini Venkateswaran, Daniel S Choi, Wendy W Lee
Introduced in 2008 and subsequently popularized in South Korea, cosmetic eye whitening has been offered as a treatment of chronic conjunctival hyperemia. Patients undergo conjunctivectomy with topical mitomycin C (MMC) 0.02% application to achieve a whitened appearance from bleaching of avascular sclera. Much speculation has arisen from this procedure given the limited available evidence on its efficacy and safety. A literature search was performed to review common complications of cosmetic eye whitening, including chronic conjunctival epithelial defects, scleral thinning, avascular zones in the sclera, dry eye syndrome, and diplopia requiring strabismus surgery...
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29115899/therapeutic-inhibitors-for-the-treatment-of-dry-eye-syndrome
#7
Candela Rodríguez-Pomar, Jesus Pintor, Basilio Colligris, Gonzalo Carracedo
Dry eye disease (DED), defined as a multifactorial disease of tears and ocular surface, results in symptoms of discomfort, ocular irritation, visual disturbance and tear film instability. This syndrome is accompanied of ocular surface inflammation and it is produced by a deficient activity of the lacrimal functional unit. In addition, it is associated with systemic autoimmune diseases such as Sjögren´s Syndrome, rheumatoid arthritis, systemic lupus erythematosus and some drug administration. The treatment of dry eye disease is based on the typical signs and symptoms of dry eye, which are associated with hyperosmolarity, ocular surface inflammation, discomfort, visual disturbance, and tear film instability...
November 14, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29114189/computer-vision-syndrome-prevalence-knowledge-and-associated-factors-among-saudi-arabia-university-students-is-it-a-serious-problem
#8
Sultan H Al Rashidi, H Alhumaidan
Objectives: Computers and other visual display devices are now an essential part of our daily life. With the increased use, a very large population is experiencing sundry ocular symptoms globally such as dry eyes, eye strain, irritation, and redness of the eyes to name a few. Collectively, all such computer related symptoms are usually referred to as computer vision syndrome (CVS). The current study aims to define the prevalence, knowledge in community, pathophysiology, factors associated, and prevention of CVS...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29098537/duplex-tear-film-evaporation-analysis
#9
M R Stapf, R J Braun, P E King-Smith
Tear film thinning, hyperosmolarity, and breakup can cause irritation and damage to the human eye, and these form an area of active investigation for dry eye syndrome research. Recent research demonstrates that deficiencies in the lipid layer may cause locally increased evaporation, inducing conditions for breakup. In this paper, we explore the conditions for tear film breakup by considering a model for tear film dynamics with two mobile fluid layers, the aqueous and lipid layers. In addition, we include the effects of osmosis, evaporation as modified by the lipid, and the polar portion of the lipid layer...
November 2, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29098081/reduced-expression-of-vamp8-in-lacrimal-gland-affected-by-chronic-graft-versus-host-disease
#10
Masaki Fukui, Yoko Ogawa, Shin Mukai, Mizuka Kamoi, Teru Asato, Yutaka Kawakami, Kazuo Tsubota
Purpose: To investigate whether the SNARE protein vesicle-associated membrane protein 8 (VAMP8) was implicated in the development of chronic ocular graft-versus-host disease (GVHD). Methods: Firstly, the chronic GVHD (cGVHD) and Sjögren's syndrome (SS)-impaired lacrimal gland (LG) tissue sections from humans for diagnostic purpose were evaluated for VAMP8 expression by histopathology and immunohistochemistry. Next, serial changes of tear secretion and VAMP8 expression at both protein and mRNA level of LG in an animal cGVHD model compared with the syngeneic control...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29079859/evaluation-of-decellularized-porcine-jejunum-as-a-matrix-for-lacrimal-gland-reconstruction-in-vitro-for-treatment-of-dry-eye-syndrome
#11
Isobel Massie, Kristina Spaniol, Andreas Barbian, Gereon Poschmann, Kai Stühler, Gerd Geerling, Marco Metzger, Sonja Mertsch, Stefan Schrader
Purpose: Dry eye syndrome (DES) can cause blindness in severe cases, but mainly palliative treatments exist. A tissue-engineered lacrimal gland (LG) could provide a curative treatment. We aimed to evaluate decellularized porcine jejunum (SIS-Muc) as a scaffold for porcine LG epithelial cells. Methods: To evaluate SIS-Muc as a potential scaffold, basement membrane proteins in SIS-Muc and native LG were compared (immunohistochemistry [IHC]). Porcine LG epithelial cells cultured on plastic were characterized (immunocytochemistry), and their culture supernatant was compared with porcine tears (proteomics)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29069259/endoscopic-endonasal-approach-for-mass-resection-of-the-pterygopalatine-fossa
#12
Jan Plzák, Vít Kratochvil, Adam Kešner, Pavol Šurda, Aleš Vlasák, Eduard Zvěřina
OBJECTIVES: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. The surgical aim of the present study was to evaluate the utility of the endoscopic endonasal approach for the management of both benign and malignant tumors of the pterygopalatine fossa. METHOD: We report our experience with the endoscopic endonasal approach for the management of both benign and malignant tumors and summarize recent recommendations...
October 2017: Clinics
https://www.readbyqxmd.com/read/29068175/micro-instillation-of-fluorescein-with-an-inoculation-loop-for-ocular-surface-staining-in-dry-eye-syndrome
#13
Emilie Courrier, Didier Renault, Mathilde Kaspi, Agathe Marcon, Victor Lambert, Thibaud Garcin, Frederic Chiambaretta, Gerhard Garhofer, Gilles Thuret, Philippe Gain
PURPOSE: To describe and validate the micro-instillation of fluorescein on the ocular surface by a disposable calibrated inoculation loop to improve corneal and conjunctival staining quality. METHODS: Accuracy and precision of the volume of 0.5% sodium fluorescein collected by a single use 1 μl-calibrated inoculation loop were measured using a precision balance. Twenty patients (40 eyes) suffering from dry eye syndrome were enrolled in a prospective interventional nonrandomized study...
October 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29062782/the-impact-of-combined-oral-contraceptives-on-ocular-tissues-a-review-of-ocular-effects
#14
REVIEW
Marilita M Moschos, Eirini Nitoda
The aim of this manuscript is to review the action and adverse effects of combined oral contraceptives (COCs) on ocular tissues. The percentage of unwanted pregnancies and the subsequent abortions make contraception crucial worldwide. Over 100 million women around the world use common contraceptive methods, including intrauterine devices, combined estrogen and progestin oral contraceptives, as well as progestin only preparations (oral contraceptives, implants or injections). COCs are widely used for contraception, but they are also indicated in menorrhagia, endometriosis, acne and hirsutism, fibroid uterus and premenstrual syndrome...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29053399/new-pathogenic-variant-in-the-fgf10-gene-in-the-agenesis-of-lacrimal-and-salivary-gland-syndrome-ophthalmological-and-genetic-study
#15
Maria Jesus Rodrigo, Miriam Idoipe, Silvia Izquierdo, Maria Satue, Antonio Mateo, Antonio Sanchez, Elena Garcia-Martin, Luis Pablo
Aplasia/agenesis of lacrimal and salivary glands is a rare congenital defect that has been associated with disturbances in fibroblast growth factor 10 (FGF10). It can present with symptoms of congenital lacrimal obstruction, dry eye, and dry mouth. We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene.
October 20, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29052094/severe-physical-complications-among-survivors-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#16
Cristina Olteanu, Neil H Shear, Hall F Chew, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Michael Ziv, Shachar Sade, Marc G Jeschke, Roni P Dodiuk-Gad
INTRODUCTION: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. OBJECTIVE: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN. METHODS: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records...
October 19, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29044077/ophthalmic-manifestations-in-rothmund-thomson-syndrome-case-report-and-review-of-literature
#17
J T Chinmayee, G R Meghana, R K Prathiba, T K Ramesh
A 24-year-old male patient presented to us with diminution of vision in both eyes with watering and photophobia for the past 8 years. General physical examination showed short stature and poikiloderma. Ocular findings include photophobia with reflex tearing, dry eye, cicatricial ectropion, symblepharon approaching pupillary area of cornea, and multiple superficial punctuate erosions on the cornea. Both eyelids showed scanty meibomian glands on infrared meibography. The rest of the anterior and posterior segment was normal...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29042648/proteomic-analysis-of-human-lacrimal-and-tear-fluid-in-dry-eye-disease
#18
Jae Hun Jung, Yong Woo Ji, Ho Sik Hwang, Jae Won Oh, Hyun Chang Kim, Hyung Keun Lee, Kwang Pyo Kim
To understand the pathophysiology of dry eye disease (DED), it is necessary to characterize proteins in the ocular surface fluids, including tear fluid (TF) and lacrimal fluid (LF). There have been several reports of TF proteomes, but few proteomic studies have examined LF secreted from the lacrimal gland (LG). Therefore, we characterized the proteins constituting TF and LF by liquid chromatography mass spectrometry. TF and LF were collected from patients with non-Sjögren syndrome DED and from healthy subjects...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040122/treatment-and-resolution-of-filamentary-keratitis-in-a-patient-with-stiff-person-syndrome
#19
Steven S Bae, Sonia N Yeung, Clara C Chan
PURPOSE: To report a rare case of filamentary keratitis associated with stiff person syndrome. METHODS: Case report. RESULTS: A 26-year-old woman with several autoimmune conditions was referred because of filamentary keratitis. Conservative management using lubrication, mucolytics, and bandage contact lenses failed to adequately relieve symptoms. Despite the addition of oral prednisone, cyclosporine, and azathioprine, the patient's condition persisted with numerous filaments and severe dry eye...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29036609/computed-flow-and-fluorescence-over-the-ocular-surface
#20
Longfei Li, R J Braun, W D Henshaw, P E King-Smith
Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical model for tear film flow, evaporation, solutal transport and fluorescence over the exposed ocular surface during the interblink. Transport of the fluorescein ion by fluid flow in the tear film affects the intensity of fluorescence via changes in concentration and tear film thickness...
September 27, 2017: Mathematical Medicine and Biology: a Journal of the IMA
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