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https://www.readbyqxmd.com/read/28346212/stability-of-extemporaneously-prepared-hydroxycarbamide-oral-suspensions
#1
Djamila Kabiche, Issa-Bella Balde, Elyes Majoul, Sofiane Kabiche, Elodie Bourguignon, Jean-Eudes Fontan, Salvatore Cisternino, Jöel Schlatter
Hydroxycarbamide, available as tablets, is a pharmacological agent for fetal hemoglobin induction such as sickle cell anemia. The need for alternative dosage form options for patients unable to take tablets led hospital pharmacies to prepare solutions and suspensions. The objective of this study was to determine the stability of hydroxycarbamide in Ora-Plus in combination with either Ora-Sweet or Ora-Sweet SF, Ora-Blend, or Ora-Blend SF suspending agents. The studied samples were compounded into 100-mg/mL suspensions and stored in 60-mL amber glass bottles at room (22°C to 25°C) or refrigerated (4°C to 8°C) temperature...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28340207/effect-of-the-2014-2015-ebola-outbreak-on-reproductive-health-services-in-a-rural-district-of-guinea-an-ecological-study
#2
Bienvenu S Camara, Alexandre Delamou, Ermias Diro, Abdoul H Béavogui, Alison M El Ayadi, Sidikiba Sidibé, Fassou M Grovogui, Kudakwashe C Takarinda, Patrice Bouedouno, Sah D Sandouno, Junko Okumura, Mamadou D Baldé, Johan Van Griensven, Rony Zachariah
Background: The 2014/2015 Ebola outbreak was the most sustained in history. In Guinea, we compared trends in family planning, antenatal care, and institutional deliveries over the period before, during and after the outbreak. Methods: We carried out an ecological study involving all the health facilities during pre-Ebola (1 March 2013 to 28 February 2014), intra-Ebola (1 March 2014 to 28 February 2015) and post-Ebola (1 March to 31 July 2016) periods in Macenta district...
March 18, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28328705/novel-approach-to-treating-androgenetic-alopecia-in-females-with-photobiomodulation-low-level-laser-therapy
#3
Shelly Friedman, Patricia Schnoor
BACKGROUND: Photobiomodulation, also referred to as low-level laser therapy (LLLT), has been studied and used for (among other diseases) the promotion of hair regrowth. OBJECTIVE/MATERIALS AND METHODS/RESULTS: A clinical study was developed to define the physiologic effects that occur when the human hair follicle and surrounding tissue structures are exposed to laser light using a novel device that is fitted with an array of laser diode sources operating at 650 nm and placed inside a sports cap to promote discretion while in use...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28323050/antiplasmodial-activity-of-mezoneuron-benthamianum-leaves-and-identification-of-its-active-constituents
#4
Olivia Jansen, Alembert T Tchinda, Jean Loua, Virginie Esters, Ewa Cieckiewicz, Allison Ledoux, Paul D Toukam, Luc Angenot, Monique Tits, Aliou M Balde, Michel Frédérich
ETHNOPHARMACOLOGICAL RELEVANCE: Decoctions of the leaves of M. benthamianum Baill. are used by traditional healers in Guinea to treat malaria and this use was validated by a preliminary clinical assay. AIM OF THE STUDY: To evaluate the in vitro antiplasmodial activity and to identify active compounds from extracts of M. benthamianum leaves. MATERIAL AND METHODS: Antiplasmodial activity of extracts, fractions and pure compounds was evaluated in vitro against a chloroquine-sensitive strain of Plasmodium falciparum (3D7) using the measurement of the plasmodial lactate dehydrogenase activity...
March 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28316922/miracle-cells-for-natural-dentistry-a-review
#5
REVIEW
Rani Somani, Shipra Jaidka, Neeti Bajaj, Sameksha Arora
Stem cells are undifferentiated cells that can differentiate into specialized cells. Recently, enormous growth has been seen in the recognition of stem cell-based therapies, which have the potential to ameliorate the life of patients with conditions that span from Parkinson's disease to cardiac ischemia to bone or tooth loss. This research has produced new but unexplored possibilities in the regeneration of different organs and tissues. Presently, research is focused on the proficiency of stem cells and their utilization in dentistry, which is gaining interest...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28274230/appraisal-of-phytochemical-and-in-vitro-biological-attributes-of-an-unexplored-folklore-rhus-punjabensis-stewart
#6
Saira Tabassum, Madiha Ahmed, Bushra Mirza, Muhammad Naeem, Muhammad Zia, Zabta Khan Shanwari, Gul Majid Khan
BACKGROUND: The role of plants for discovery of therapeutic potential accentuates the need to know their biological attributes. The present study aims to comprehend the biological attributes of Rhus punjabensis, an unexplored traditional medicinal plant. METHODS: Leaf and stem extracts of R. punjabensis prepared in 11 different organic solvents are evaluated for multimode antioxidant potential, total phenolic and flavonoid contents were determined through colorimetric assays, HPLC-DAD analysis was carried out for quantification of various polyphenols in extracts...
March 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28272467/meta-analysis-identifies-novel-risk-loci-and-yields-systematic-insights-into-the-biology-of-male-pattern-baldness
#7
Stefanie Heilmann-Heimbach, Christine Herold, Lara M Hochfeld, Axel M Hillmer, Dale R Nyholt, Julian Hecker, Asif Javed, Elaine G Y Chew, Sonali Pechlivanis, Dmitriy Drichel, Xiu Ting Heng, Ricardo C-H Del Rosario, Heide L Fier, Ralf Paus, Rico Rueedi, Tessel E Galesloot, Susanne Moebus, Thomas Anhalt, Shyam Prabhakar, Rui Li, Stavroula Kanoni, George Papanikolaou, Zoltán Kutalik, Panos Deloukas, Michael P Philpott, Gérard Waeber, Tim D Spector, Peter Vollenweider, Lambertus A L M Kiemeney, George Dedoussis, J Brent Richards, Michael Nothnagel, Nicholas G Martin, Tim Becker, David A Hinds, Markus M Nöthen
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10(-8), METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options...
March 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28270628/temperature-induced-remodeling-of-the-photosynthetic-machinery-tunes-photosynthesis-in-a-thermophyllic-alga
#8
Denitsa Nikolova, Dieter Weber, Martin Scholz, Till Bald, Jörn Peter Scharsack, Michael Hippler
The thermophilic alga C. merolae thrives in extreme environments (low pH and temperature between 40 and 56{degree sign}C. In this study we investigated the acclimation process of the alga to a colder temperature (25{degree sign}C). A long-term cell growth experiment revealed an extensive remodeling of the photosynthetic apparatus in the first 250 h of acclimation, which was followed by cell growth to an even higher density than the control (grown at 42{degree sign}C) cell density. Once the cells were shifted to the lower temperature, the proteins of the light-harvesting antenna were greatly down regulated and the phycobilisome (PBS) composition was altered...
March 7, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28270190/social-media-for-arthritis-related-comparative-effectiveness-and-safety-research-and-the-impact-of-direct-to-consumer-advertising
#9
Jeffrey R Curtis, Lang Chen, Phillip Higginbotham, W Benjamin Nowell, Ronit Gal-Levy, James Willig, Monika Safford, Joseph Coe, Kaitlin O'Hara, Roee Sa'adon
BACKGROUND: Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure. METHODS: The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory arthritis (e.g. rheumatoid, psoriatic). Safety events were self-reported by patients and mapped to medical ontologies, resolving synonyms. Disease and symptom-related treatment indications were manually redacted...
March 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28265294/the-bare-head-of-the-northern-bald-ibis-geronticus-eremita-fulfills-a-thermoregulatory-function
#10
REVIEW
Ismael Galván, Daniel Palacios, Juan José Negro
BACKGROUND: Dark pigments provide animals with several adaptive benefits such as protection against ultraviolet (UV) radiation and mechanical abrasion, but may also impose several constraints like a high absorbance of solar radiation. Endotherms, with relatively constant and high body temperatures, may be especially prone to thermoregulatory limitations if dark coloured and inhabiting hot environments. It is therefore expected that adaptations have specifically evolved because of these limitations...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28263792/a-genomic-approach-to-susceptibility-and-pathogenesis-leads-to-identifying-potential-novel-therapeutic-targets-in-androgenetic-alopecia
#11
R Dey-Rao, A A Sinha
We studied genome-wide gene expression from bald and haired scalp of individuals to evaluate pathogenic mechanisms underlying the development and progression of androgenetic alopecia (AGA). Unbiased analyses revealed a "bald pathology" based signature. Ontology enrichment analyses of the differentially expressed genes (DEGs) underscored apoptosis, cell proliferation, perturbed neurological pathways, and WNT signaling as central drivers of the hair loss process. Interactome analysis uncovered several known and novel key transcriptional regulators potentially affecting disease pathogenesis both within and "hidden" from the dataset...
March 2, 2017: Genomics
https://www.readbyqxmd.com/read/28260759/risk-factor-pattern-of-ischemic-heart-disease-in-young-male-patients-with-vertex-baldness
#12
M A Bari, M M Rahman, G P Aditya, Z M Islam, M A Mutalib
Acute coronary syndrome (ACS) is increasingly evident in all parts of the globe as well in our country. There are accumulating evidences regarding many physical markers, like vertex baldness to predict ACS. This cross sectional study was conducted in the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from October 2014 to September 2015. The main objective of the study was to assess the risk factors of premature coronary artery disease (CAD) of male patient of Acute Coronary Syndrome with or without vertex baldness...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28244511/effect-of-adsorption-kinetics-on-dissociation-of-dna-nucleobases-on-gold-nanoparticles-under-pulsed-laser-illumination
#13
Robin Schürmann, Ilko Bald
Photothermal therapy is a novel approach to destroy cancer cells by an increase of temperature due to laser illumination of gold nanoparticles (GNPs) that are incorporated into the cells. Here, we study the decomposition of DNA nucleobases via irradiation of gold nanoparticles with ns-laser pulses. The kinetics of the adsorption and decomposition process is described by a theoretical model based on the Langmuir assumptions and correlated with experimentally determined reaction rates revealing a strong influence of the nucleobase specific adsorption...
February 28, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28207161/prenatal-diagnosis-of-congenital-cytomegalovirus-infection-in-115-cases-a-5%C3%A2-years-single-centre-experience
#14
M Enders, A Daiminger, S Exler, K Ertan, G Enders, R Bald
OBJECTIVE: To investigate the diagnostic value of invasive prenatal diagnosis (PD) of congenital CMV infection from amniotic fluid (AF) and fetal blood (FB) METHODS: Retrospective study on 115 pregnancies with CMV primary infection. A total of 111 AF and 106 FB samples were investigated for various virological and non-virological markers. Detailed ultrasound examinations were performed at time of PD. RESULTS: Overall sensitivity of CMV PCR in FB (75.6%; 95%CI 60-87) and AF (72...
February 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28196072/genetic-prediction-of-male-pattern-baldness
#15
Saskia P Hagenaars, W David Hill, Sarah E Harris, Stuart J Ritchie, Gail Davies, David C Liewald, Catharine R Gale, David J Porteous, Ian J Deary, Riccardo E Marioni
Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x10-8). By splitting the cohort into a discovery sample of 40,000 and target sample of 12,000, we developed a prediction algorithm based entirely on common genetic variants that discriminated (AUC = 0...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28192041/a-systematic-review-of-carrion-eaters-adaptations-to-avoid-sickness
#16
Daniel T Blumstein, Tiana N Rangchi, Tiandra Briggs, Fabrine Souza De Andrade, Barbara Natterson-Horowtiz
Species that scavenge on dead animals are exposed to enhanced disease risks. Eight hypotheses have been suggested to explain how scavengers avoid becoming sick from their diet. We conducted a systematic review of the literature and found correlative support for four of the eight hypotheses but limited evidence of systematic studies of the hypotheses. We found no support that using urine to sterilize carcasses, having bald heads, eating rapidly, or food-washing behavior reduced disease risk in carrion eaters...
February 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28180973/fatal-attack-on-a-rylands-bald-faced-saki-monkey-pithecia-rylandsi-by-a-black-and-white-hawk-eagle-spizaetus-melanoleucus
#17
Dara B Adams, Sean M Williams
Predation risk has played an important role in primate behavioral evolution, yet natural primate-predator interactions are rarely observed. We describe the consumption and probable predation of an adult bald-faced saki monkey (Pithecia rylandsi) by a black-and-white hawk-eagle (Spizaetus melanoleucus) at the Los Amigos Biological Station in lowland Amazonian Peru. To our knowledge, this is the first published case of a black-and-white hawk-eagle consuming any primate species. We contend that while most reported observations of successful and attempted predation by raptors involves the largest and most notorious species (i...
February 8, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28139440/the-parasternal-short-axis-view-improves-diagnostic-accuracy-for-inferior-sinus-venosus-type-of-atrial-septal-defects-by-transthoracic-echocardiography
#18
Brian S Snarr, Michael Y Liu, Jeremy C Zuckerberg, Christine B Falkensammer, Sumekala Nadaraj, Danielle Burstein, Deborah Ho, Monique A Gardner, Arene Butto, Stanford G Ewing, Natesa G Pandian, Anirban Banerjee
BACKGROUND: Sinus venosus defects (SVD) of the inferior vena cava (IVC) type, or inferior SVDs, are an uncommon form of atrial communication located outside the confines of the fossa ovalis and involve override of the IVC. Despite numerous studies describing the anatomical and echocardiographic features of the inferior SVD, distinguishing this defect from a large secundum atrial septal defect (ASD) by echocardiography is often challenging. Accurate diagnosis of an inferior SVD and correct differentiation from a secundum ASD is essential for appropriate presurgical planning...
March 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28135132/mercury-exposure-in-bald-eagles-admitted-for-rehabilitation-in-iowa-usa
#19
Julie A Blanchong, William J Reiter-Marolf, Stephen J Dinsmore
To gain insight into mercury exposure in Bald Eagles ( Haliaeetus leucocephalus ) in Iowa we collected blood from 22 rehabilitation eagles in 2012-13. The geometric mean blood mercury level was 0.144 μg/g (95% confidence interval: 0.066-0.314) and was at the lower end of the range of levels reported elsewhere.
January 30, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28125360/monitoring-total-body-inflammation-and-damage-in-joints-and-entheses-the-first-follow-up-study-of-whole-body-magnetic-resonance-imaging-in-rheumatoid-arthritis
#20
M B Axelsen, I Eshed, M Østergaard, M L Hetland, J M Møller, D V Jensen, S B Krintel, M S Hansen, L Terslev, M Klarlund, R P Poggenborg, L Balding, S J Pedersen
OBJECTIVE: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. METHODS: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses...
January 26, 2017: Scandinavian Journal of Rheumatology
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