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https://www.readbyqxmd.com/read/29336512/using-field-data-to-quantify-chemical-impacts-on-wildlife-population-viability
#1
Jelle P Hilbers, Renske P J Hoondert, Aafke M Schipper, Mark A J Huijbregts
Environmental pollution is an important driver of biodiversity loss. Yet, to date, the effects of chemical exposure on wildlife populations have been quantified for only a few species, mainly due to a lack of appropriate laboratory data to quantify chemical impacts on vital rates. In this study we developed a method to quantify the effects of toxicant exposure on wildlife population persistence based on field monitoring data. We established field-based vital rate-response functions for toxicants, using quantile regression to correct for the influences of confounding factors on the vital rates observed, and combined the response curves with population viability modelling...
January 16, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29325146/dramatic-changes-in-malaria-population-genetic-complexity-in-dielmo-and-ndiop-senegal-revealed-using-genomic-surveillance
#2
Amy K Bei, Makhtar Niang, Awa B Deme, Rachel F Daniels, Fatoumata D Sarr, Cheikh Sokhna, Cheikh Talla, Joseph Faye, Nafissatou Diagne, Souleymane Doucoure, Souleymane Mboup, Dyann F Wirth, Adama Tall, Daouda Ndiaye, Daniel L Hartl, Sarah K Volkman, Aissatou Toure-Balde
Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points in the Dielmo/Ndiop longitudinal cohorts from Senegal, we applied a molecular barcode tool to detect changes in parasite genotypes and complexity of infection that corresponded to changes in transmission intensity. We observed a striking statistically significant difference in genetic diversity between the 2 parasite populations. Furthermore, we identified a genotype in Dielmo and Ndiop previously observed in Thiès, potentially implicating imported malaria...
January 9, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29322328/vaccination-titres-pre-and-post-transplant-in-paediatric-renal-transplant-recipients-and-the-impact-of-immunosuppressive-therapy
#3
Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Martin Bald, Jens König, Stephen D Marks, Gurkan Genc, Anja Büscher, Markus J Kemper, Heiko Billing, Martin Pohl, Luca Dello Strologo, Nicholas J A Webb, Susanne Rieger, Annette Mankertz, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff
BACKGROUND: Avoidance of vaccine-preventable infections in paediatric renal allograft recipients is of utmost importance. However, the development and maintenance of protective vaccination titres may be impaired in this patient population owing to their need for immunosuppressive medication. METHODS: In the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national study and analysed vaccination titres pre- and post-transplant in 155 patients with serial titre measurements in comparison with published data in healthy children...
January 10, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29321681/in-vivo-monitoring-of-hair-cycle-stages-via-bioluminescence-imaging-of-hair-follicle-ng2-cells
#4
Yasuhisa Tamura, Kumi Takata, Asami Eguchi, Yosky Kataoka
Hair growth occurs periodically in a cycle that consists of three different phases: growth, regression, and resting. The length of each phase is regulated by both intrinsic and extrinsic factors throughout life, and influenced by physiological and pathological conditions. Elongation of the resting phase and shortening of the growth phase occur during physiological ageing and in baldness, respectively. In vivo discrimination of each phase of the hair cycle can be used to research for regeneration of hair follicles as well as to evaluate the efficacy of hair regrowth treatments in the same individual...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318957/research-brief-self-reports-of-a-constellation-of-persistent-antiandrogenic-estrogenic-physical-and-psychological-effects-of-finasteride-usage-among-men
#5
Alicia A Walf, Shan Kaurejo, Cheryl A Frye
Our research objective is to understand more, through subjective, self-reports on discussion boards/forums, persons' experiences associated with the use of drugs that alter androgen metabolism, such as finasteride. Finasteride is an orally active, specific inhibitor of 5α-reductase, which is localized to many androgen-dependent tissues. Finasteride inhibits the conversion of testosterone (T) to dihydrotestosterone (DHT), and is commonly used to treat benign prostatic hypertrophy (BPH) and male pattern baldness (MPB), both disorders associated with elevated DHT levels and 5α-reductase activity in the prostate and hair follicles, respectively...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29305634/-thoracic-inflammatory-pseudotumors-a%C3%A2-rare-differential-diagnosis
#6
S Sponholz, M Schirren, N Baldes, L Schreiner, A Fisseler-Eckhoff, J Schirren
BACKGROUND: Inflammatory pseudotumors are a rare and in the main benign tumor entity but infiltrative growth, recurrence and metastases are described. Generally, a complete resection is needed to exclude lung cancer. This study analyzed our data and experiences with this rare tumor entity. MATERIAL AND METHODS: We performed a retrospective study of all our patients who had been operated on between 2002 and 2016 in our institution for an inflammatory pseudotumor of the lungs...
January 5, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29297940/oral-mucosa-lesions-and-gingival-bleeding-can-indicate-the-progression-of-liver-disease-in-children-and-adolescents-aged-two-to-18-years
#7
Dorota Olczak-Kowalczyk, Ewa Krasuska-Sławińska, Dariusz Gozdowski, Wojciech Kowalczyk, Joanna Pawłowska
AIM: This study assessed correlations between systemic disturbances of paediatric chronic liver diseases (CLD) and oral symptoms in subjects aged 2-18 years. METHODS: It was carried out during outpatient appointments at the Children's Memorial Health Institute, Warsaw, Poland, from 2010-2015 and comprised 52 CLD patients with a mean age of 12.3 ±4.6. We also recruited 54 generally healthy controls with a mean age of 12.0 ±3.7 from the Department of Paediatric Dentistry at the Medical University of Warsaw...
January 3, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29297805/the-effects-of-migratory-flight-on-hematologic-parameters-in-northern-bald-ibises-geronticus-eremita
#8
Gabriela Stanclova, Ilse Schwendenwein, Olaf Merkel, Lukas Kenner, John Dittami, Johannes Fritz, Alexandra Scope
Under the project of "Human-Led Migration," the authors had the unique opportunity to accompany hand-raised northern bald Iibises (NBIs; Geronticus eremita) during migration, which occurred in stages from Bavaria, Germany, to southern Tuscany, Italy. The aim of this study was to investigate the immediate effects of flight, with respect to flight duration, and the more delayed recovery effects on hematologic variables. A total of 31 birds were sampled. Blood samples were taken immediately before takeoff, after landing, and 1 day after the flight...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29284488/unexpected-high-circulation-of-plasmodium-vivax-in-asymptomatic-children-from-k%C3%A3-dougou-southeastern-senegal
#9
Makhtar Niang, Fode Diop, Oulimata Niang, Bacary D Sadio, Abdourahmane Sow, Ousmane Faye, Mawlouth Diallo, Amadou A Sall, Ronald Perraut, Aissatou Toure-Balde
BACKGROUND: Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. By the use of molecular methods, detection of Plasmodium vivax has been recently reported in the region of Kedougou, raising the question of appraisal of its potential prevalence in this setting. METHODS: A retrospective serological study was carried out using 188 samples taken from 2010 to 2011 in a longitudinal school survey during which 48 asymptomatic children (9-11 years) were recruited...
December 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29273104/quantifying-alopecia-areata-via-texture-analysis-to-automate-the-salt-score-computation
#10
Elena Bernardis, Leslie Castelo-Soccio
Quantifying alopecia areata in real time has been a challenge for clinicians and investigators. Although several scoring systems exist, they can be cumbersome. Because there are more clinical trials in alopecia areata, there is an urgent need for a quantitative system that is reproducible, standardized, and simple. In this article, a computer imaging algorithm to recreate the Severity of Alopecia Tool scoring system in an automated way is presented. A pediatric alopecia areata image set of four view-standardized photographs was created, and texture analysis was used to distinguish between normal hair and bald scalp...
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29237093/serum-androgens-and-psa-levels-in-androgenetic-alopecia-is-there-a-difference-between-frontal-and-vertex-baldness
#11
Anna Lis-Święty, Hubert Arasiewicz, Irmina Ranosz-Janicka, Ligia Brzezińska-Wcisło
BACKGROUND: Androgenetic alopecia (AGA) seems to be a marker of increased risk of prostate cancer (PCa). OBJECTIVE: We sought to investigate potential pathophysiological differences between frontal and vertex balding that might have the impact on the incidence of PCa. METHODS: Serum concentrations of testosterone (T), dihydrotestosterone (DHT) and prostate-specific antigen (PSA) were measured in 88 subjects with AGA. RESULTS: We have examined sixty patients with frontal baldness and 28 patients with vertex baldness...
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29232032/erosive-pustular-dermatosis-of-the-scalp-reappraisal-of-an-underrecognized-entity
#12
REVIEW
Michael Wilk, Bettina G Zelger, Undine Hauser, Reinhard Höpfl, Bernhard Zelger
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis of unknown etiology. Herein, we present a review of the disease and report our own clinical and histopathological experience in eleven patients. EPDS tends to spontaneously affect bald areas of the scalp in elderly individuals. A history of previous surgery at the same site - as observed in four of our patients - is common. Coronary artery disease, cerebrovascular insult, arterial hypertension, diabetes mellitus, and severe cases of cancer were frequent comorbidities...
December 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29224979/perceptions-knowledge-attitudes-and-practices-for-the-prevention-and-control-of-lymphatic-filariasis-in-conakry-republic-of-guinea
#13
Bernard L Kouassi, Aboulaye Barry, Kathrin Heitz-Tokpa, Stefanie J Krauth, Andre Goépogui, Mamadou S Baldé, Oumar Barry, Marie L Niamey, Moses J Bockarie, Benjamin G Koudou, Jürg Utzinger
Little is known about the perceptions, attitudes and practices of lymphatic filariasis in Conakry, Republic of Guinea. Yet, such knowledge is important for an optimal design and implementation of setting-specific prevention and control measures. We conducted a cross-sectional study using a mixed methods approach. Qualitative data related to people's general experience with lymphatic filariasis, their perception of the causes of the disease, the onset of elephantiasis, care-seeking behaviour and the socioeconomic impact of lymphatic filariasis were collected by in-depth interviews with 85 respondents...
December 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29211936/avian-scavenging-of-small-sized-pig-carcasses-in-central-florida-utilizing-gis-to-analyze-site-variables-affecting-skeletal-dispersal
#14
John J Schultz, Alexander T Mitchell
Scavengers can significantly alter a forensic scene and consume, modify, disarticulate, and disperse bodies on the ground surface. The research purpose was to examine vulture scavenging in central Florida, USA. Four small-sized pig (Sus scrofa) carcasses were left on the ground surface of two microenvironments (shaded and open) at a secure site with game cameras. Dispersal data were mapped and analyzed using geographical information systems spatial analysis digital mapping tools. The primary avian scavengers recorded included black vultures (Coragyps atratus) and turkey vultures (Cathartes aura), as well as bald eagles (Haliaeetus leucocephalus)...
December 6, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29207731/sodium-valproate-induced-alopecia-a-case-series
#15
Sereen Rose Thomson, Vinay Mamulpet, Shalini Adiga
Drug induced alopecia may range from a barely detectable shedding to an irreversible baldness. Alopecia associated with valproate is a dose-dependent and reversible side effect. We hereby report, three cases of alopecia that occurred in patients who received sodium valproate for various neurological conditions. In all three cases, long term exposure of valproate therapy led to the development of alopecia which eventually resolved after dose reduction or discontinuation. The Naranjo's causality assessment scale indicated valproate as the probable cause of the alopecia in all our patients...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29201075/development-and-evaluation-of-patient-information-leaflet-for-diabetic-foot-ulcer-patients
#16
Sonal Sekhar M, Unnikrishnan Mk, Navya Vyas, Gabriel Sunil Rodrigues
Background: Patient education (PE) is as important as medical and surgical interventions in the management of diabetic foot ulcer (DFU). Patient information leaflets (PILs) are globally accepted patient counseling aids. Objectives: This study aimed at developing PILs for DFU patients and investigating its validation. Methods: The PILs were prepared based on different model leaflets available from various online resources, including "Patient UK"...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29200765/simvastatin-ezetimibe-therapy-for-recalcitrant-alopecia-areata-an-open-prospective-study-of-14-patients
#17
Joong-Woon Choi, Dong-Woo Suh, Bark-Lynn Lew, Woo-Young Sim
Background: Simvastatin belongs to the statin family, whose members have immunomodulatory activities. Ezetimibe have synergetic effects when co-administered with simvastatin. In several case reports, alopecia totalis and alopecia universalis were successfully treated with simvastatin/ezetimibe, suggesting that this combination could be a new efficient therapy for recalcitrant alopecia areata (AA). Objective: To verify the efficacy of the simvastatin/ezetimibe combination therapy for recalcitrant AA and investigate the relationship between various treatment responses and prognostic factors...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29191238/ethnopharmacological-studies-of-indigenous-plants-in-kel-village-neelum-valley-azad-kashmir-pakistan
#18
Khawaja Shafique Ahmad, Abdul Hamid, Fahim Nawaz, Mansoor Hameed, Farooq Ahmad, Jiabin Deng, Noreen Akhtar, Ambreen Wazarat, Sehrish Mahroof
BACKGROUND: This explorative study was undertaken for the first time in Kel village located in the Upper Neelum Valley, Azad Kashmir, Pakistan. The purpose was to document the indigenous knowledge of the native people used in the preparation of herbal medicines. METHODS: To get the data on traditional uses of medicinal plants, 20 informants were interviewed. Quantitative ethnobotanical indices, i.e., use value (UV), relative frequencies of citation (RFC), informant consensus factor (Fic), fidelity level (FL), data matrix ranking (DMR), preference ranking (PR), and jaccard index (JI), were calculated for the recorded medicinal plants...
December 1, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29190454/phenolic-metabolites-from-hypericum-kelleri-bald-an-endemic-species-of-crete-greece
#19
Angeliki Mathioudaki, Ariola Berzesta, Zacharias Kypriotakis, Helen Skaltsa, Jörg Heilmann
Thirteen compounds were isolated from the aerial parts of Hypericum kelleri Bald., growing as an endemic on the island of Crete (Greece). These compounds comprise four previously unknown prenylated xanthones 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine A), 1,2-dihydro-3,6,8-trihydroxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine B), 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1-bi(3-methylbut-2-enyl)xanthen-2,9-dione (6-methylpatulone), (R/S)-1,3,5-trihydroxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-6-methoxy-9H-xanthen-9-one ((2″R/S)-kellerine C) and the hitherto undescribed depsidone (R/S)-1,3,6-trihydroxy-5-methoxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-11Η-dibenzo[b,e] [1,4]dioxepin-9-one ((2″R/S)-creticine)...
November 27, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29188608/-cadasil-with-clinical-manifestations-of-baldness-lumbago-and-parkinson-s-symptoms
#20
Zhixia Ren, Shuai Chen, Yingying Shi, Yuanxing Zhang, Wan Wang, Zuzhi Chen, Mingrong Xia, Xiaohong Shi, Jiewen Zhang
OBJECTIVE: To investigate a cerebral autosomal dominant arteriopathy with the subcortical infarcts and leukoencephalopathy (CADASIL) case with clinical manifestations of baldness, lumbago and Parkinson's symptoms. METHODS: Clinical and imaging data of the patient were analyzed. The patient and his family members were also subjected to genetic testing. RESULTS: The symptoms of the patient included recurrent stroke, dementia, and mood disturbance, in addition with lumbago, baldness and Parkinson's symptoms but no migraine...
December 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
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