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https://www.readbyqxmd.com/read/28925677/polypeptide-composite-particle-assisted-organization-of-%C3%AF-conjugated-polymers-into-highly-crystalline-coffee-stains
#1
Cornelia Rosu, Ping-Hsun Chu, Christopher J Tassone, Katherine Park, Paul L Balding, Jung Ok Park, Mohan Srinivasarao, Elsa Reichmanis
We demonstrate that homopolypeptides covalently tethered to anisotropically shaped silica particles induce crystalline ordering of representative semiconducting polymers. Films drop-cast from chloroform dispersions of poly(γ-stearyl-l-glutamate) (PSLG) composite particles and poly(3-hexythiophene) (P3HT) led to highly ordered crystalline structures of P3HT. Hydrophobic-hydrophobic interactions between the alkyl side chains of P3HT and PSLG were the main driving force for P3HT chain ordering into the crystalline assemblies...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28924479/marked-hyperandrogenicity-in-a-60-year-old-woman
#2
Khaled Aljenaee, Sulaiman Ali, Seong Keat Cheah, Owen MacEneaney, Niall Mulligan, Neil Hickey, Tommy Kyaw Tun, Seamus Sreenan, John H McDermott
Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21 nmol/L (normal range: 0...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28922774/crop-model-assisted-phenomics-and-genome-wide-association-study-for-climate-adaptation-of-indica-rice-1-phenology
#3
Michael Dingkuhn, Richard Pasco, Julie M Pasuquin, Jean Damo, Jean-Christophe Soulié, Louis-Marie Raboin, Julie Dusserre, Abdoulaye Sow, Baboucarr Manneh, Suchit Shrestha, Alpha Balde, Tobias Kretzschmar
Phenology and time of flowering are crucial determinants of rice adaptation to climate variation. A previous study characterized flowering responses of 203 diverse indica rices (the ORYTAGE panel) to ten environments in Senegal (six sowing dates) and Madagascar (two years and two altitudes) under irrigation in the field. This study used the physiological phenology model RIDEV V2 to heuristically estimate component traits of flowering such as cardinal temperatures (base temperature (Tbase) and optimum temperature), basic vegetative phase, photoperiod sensitivity and cold acclimation, and to conduct a genome-wide association study for these traits using 16 232 anonymous single-nucleotide polymorphism (SNP) markers...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28920782/evaluation-of-lead-and-mercury-prevalence-in-bald-eagles-haliaeetus-leucocephalus-from-the-mid-atlantic-united-states
#4
Andreas Eleftheriou, Lisa Murphy, Sallie Welte
Heavy metal contamination of the environment remains a critical issue. Lead and mercury exposure, particularly, can affect avian health. Bald eagles (Haliaeetus leucocephalus) ingest these metals through their diets. Lead and mercury prevalence were examined in bald eagles from three mid-Atlantic US states between 2004 and 2013. Blood samples were analyzed using atomic absorption spectrometry. Wilcoxon score tests were used to detect differences in lead and mercury over time. Counties of origin for birds with clinically significant metal levels were identified...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28894860/elastic-and-viscous-bond-components-in-the-adhesion-of-colloidal-particles-and-fibrillated-streptococci-to-qcm-d-crystal-surfaces-with-different-hydrophobicities-using-kelvin-voigt-and-maxwell-models
#5
Rebecca van der Westen, Prashant K Sharma, Hans De Raedt, Ijsbrand Vermue, Henny C van der Mei, Henk J Busscher
A quartz-crystal-microbalance with dissipation (QCM-D) can measure molecular mass adsorption as well as register adhesion of colloidal particles. However, analysis of the QCM-D output to quantitatively analyze adhesion of (bio)colloids to obtain viscoelastic bond properties is still a subject of debate. Here, we analyze the QCM-D output to analyze the bond between two hydrophilic streptococcal strains 91 nm long and without fibrillar surface appendages and micron-sized hydrophobic polystyrene particles on QCM-D crystal surfaces with different hydrophobicities, using the Kelvin-Voigt model and the Maxwell model...
September 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28891692/second-generation-anticoagulant-rodenticide-poisoning-in-a-captive-andean-condor-vultur-gryphus
#6
Kira L Hydock, Camille DeClementi, Pilar H Fish
A 28-year-old female Andean condor (Vultur gryphus) housed in an outside exhibit at the National Aviary in Pittsburgh, PA, began showing signs of weakness. Toxicosis with an anticoagulant rodenticide was suspected because its mate had died 1 day earlier from possible brodifacoum poisoning. A rapid decline in the packed cell volume, despite vitamin K1 treatment, necessitated a blood transfusion with blood from bald eagles (Haliaeetus leucocephalus) and Steller's sea eagles (Haliaeetus pelagicus). Supportive therapy after transfusion included vitamin K1 (5 mg/kg IM q12h) as well as enrofloxacin, vitamin B complex, selenium and vitamin E, and subcutaneous fluids as needed...
September 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28878275/a-fluorescence-based-reporter-for-monitoring-expression-of-mycobacterial-cytochrome-bd-in-response-to-antibacterials-and-during-infection
#7
Maikel Boot, Kin Ki Jim, Ting Liu, Susanna Commandeur, Ping Lu, Theo Verboom, Holger Lill, Wilbert Bitter, Dirk Bald
Cytochrome bd is a component of the oxidative phosphorylation pathway in many Gram-positive and Gram-negative bacteria. Next to its role as a terminal oxidase in the respiratory chain this enzyme plays an important role as a survival factor in the bacterial stress response. In Mycobacterium tuberculosis and related mycobacterial strains, cytochrome bd is an important component of the defense system against antibacterial drugs. In this report we describe and evaluate an mCherry-based fluorescent reporter for detection of cytochrome bd expression in Mycobacterium marinum...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877668/de-novo-assembly-of-phlomis-purpurea-after-challenging-with-phytophthora-cinnamomi
#8
Aladje Baldé, Dina Neves, Francisco J García-Breijo, Maria Salomé Pais, Alfredo Cravador
BACKGROUND: Phlomis plants are a source of biological active substances with potential applications in the control of phytopathogens. Phlomis purpurea (Lamiaceae) is autochthonous of southern Iberian Peninsula and Morocco and was found to be resistant to Phytophthora cinnamomi. Phlomis purpurea has revealed antagonistic effect in the rhizosphere of Quercus suber and Q. ilex against P. cinnamomi. Phlomis purpurea roots produce bioactive compounds exhibiting antitumor and anti-Phytophthora activities with potential to protect susceptible plants...
September 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28871817/cytotoxicity-in-vitro-anti-leishmanial-and-fingerprint-hplc-photodiode-array-analysis-of-the-roots-of-trillium-govanianum
#9
Kashif Maqbool Khan, Lutfun Nahar, Abdul Mannan, Ihsan Ul-Haq, Muhammad Arfan, Ghazanfar Ali Khan, Izhar Hussain, Satyajit D Sarker
Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae), commonly known as 'nagchhatry' or 'teen patra', distributed from Pakistan to Bhutan about 2500-3800 m altitude is indigenous to Himalayas region. In folk medicine the plant has been reported for the treatment of wound healing, sepsis and in various sexual disorders. This paper reports, for the first time, to evaluate the cytotoxicity, in vitro anti-leishmanial (promastigotes) and fingerprint HPLC-photodiode array analysis of the MeOH extract of the roots of T...
September 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28864458/optimizing-genomic-medicine-in-epilepsy-through-a-gene-customized-approach-to-missense-variant-interpretation
#10
Joshua Traynelis, Michael Silk, Quanli Wang, Samuel F Berkovic, Liping Liu, David B Ascher, David J Balding, Slavé Petrovski
Gene panel and exome sequencing have revealed a high rate of molecular diagnoses among diseases where the genetic architecture has proven suitable for sequencing approaches, with a large number of distinct and highly penetrant causal variants identified among a growing list of disease genes. The challenge is, given the DNA sequence of a new patient, to distinguish disease-causing from benign variants. Large samples of human standing variation data highlight regional variation in the tolerance to missense variation within the protein-coding sequence of genes...
September 1, 2017: Genome Research
https://www.readbyqxmd.com/read/28835071/-effects-of-axial-vascular-network-flap-of-scalp-or-anterolateral-thigh-perforator-flap-with-fascia-lata-on-repairing-defects-after-radical-resection-of-scalp-carcinoma-in-patients
#11
W F Zhang, X F Zhang, Q F Gao, X T Niu, Y J Ma, B E Wu, B Ma, F Liang, A W Wang
Objective: To observe the effects of axial vascular network flap of scalp or anterolateral thigh perforator flap with fascia lata on repairing defects after radical resection of scalp carcinoma in patients. Methods: From February 2006 to December 2015, twenty-one patients with scalp carcinoma were admitted to our hospital, and the carcinoma invaded external lamina or full-thickness of skull and dura mater. After perfect preoperative examination, carcinoma and scalp tissue in 3 to 5 cm from the edge of carcinoma, external lamina or full-thickness of skull and invaded dura mater were resected and sentinel lymph nodes around carcinoma were cleaned in 3 to 4 days after admission...
August 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28798006/breast-adenoid-cystic-carcinoma-a-rare-case-report-and-review-of-the-literature
#12
Lamiae El Amarti, Hanan Raiss, Mohamed Layachi, Salif Baldé, Hamza Ettahri, Ibrahim Elghissassi, Hind Mrabti, Hassan Errihani
BACKGROUND: Primary adenoid cystic carcinoma (ACC) of the breast is a rare subtype of invasive breast cancer. It has a particular interest because of its excellent prognosis conversely to other triple-negative breast cancers that are associated with poor prognosis. The place of chemotherapy and radiotherapy remains controversial and there is no consensus on optimal management of the ACC of the breast. CASE REPORT: A 50-year-old woman, presented with a palpable right breast lump...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28774308/polarity-directed-optimization-of-phytochemical-and-in-vitro-biological-potential-of-an-indigenous-folklore-quercus-dilatata-lindl-ex-royle
#13
Madiha Ahmed, Humaira Fatima, Muhammad Qasim, Bilquees Gul, Ihsan-Ul-Haq
BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis...
August 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28771615/substantial-asymptomatic-submicroscopic-plasmodium-carriage-during-dry-season-in-low-transmission-areas-in-senegal-implications-for-malaria-control-and-elimination
#14
Makhtar Niang, Laty Gaye Thiam, Rokhaya Sane, Nafissatou Diagne, Cheikh Talla, Souleymane Doucoure, Joseph Faye, Fode Diop, Abdoulaye Badiane, Babacar Diouf, Diogop Camara, Fatoumata Diene-Sarr, Cheikh Sokhna, Vincent Richard, Aissatou Toure-Balde
BACKGROUND: In the progress towards malaria elimination, the accurate diagnosis of low-density asymptomatic infections is critical. Low-density asymptomatic submicroscopic malaria infections may act as silent reservoirs that maintain low-level residual malaria transmission in the community. Light microscopy, the gold standard in malaria diagnosis lacks the sensitivity to detect low-level parasitaemia. In this study, the presence and prevalence of submicroscopic Plasmodium carriage were investigated to estimate the parasites reservoir among asymptomatic individuals living in low transmission areas in Dielmo and Ndiop, Senegal during the dry season...
2017: PloS One
https://www.readbyqxmd.com/read/28764775/an-assessment-on-the-role-of-endophytic-microbes-in-the-therapeutic-potential-of-fagonia-indica
#15
Lubna Rahman, Zabta K Shinwari, Irum Iqrar, Lutfur Rahman, Faouzia Tanveer
BACKGROUND: Natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. Endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. Fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. It is also reported that endophytes play a vital role in the biosynthesis of various metabolites; therefore we believe that endophytes associated with F...
August 1, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28759001/tumor-immunoevasion-by-the-conversion-of-effector-nk-cells-into-type-1-innate-lymphoid-cells
#16
Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment...
September 2017: Nature Immunology
https://www.readbyqxmd.com/read/28753412/influence-of-snowfall-on-blood-lead-levels-of-free-flying-bald-eagles-haliaeetus-leucocephalus-in-the-upper-mississippi-river-valley
#17
Ronald A Lindblom, Letitia M Reichart, Brett A Mandernack, Matthew Solensky, Casey W Schoenebeck, Patrick T Redig
Lead poisoning of scavenging raptors occurs primarily via consumption of game animal carcasses containing lead, which peaks during fall firearm hunting seasons. We hypothesized that snowfall would mitigate exposure by concealing carcasses. We categorized blood lead level (BLL) for a subsample of Bald Eagles (Haliaeetus leucocephalus) from the Upper Mississippi River Valley and described BLL with respect to age, sex, and snowfall. We captured Bald Eagles overwintering in the Upper Mississippi River Valley (n=55) between December 1999 and January 2002...
July 28, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28741586/a-new-mutation-in-the-calcium-sensing-receptor-gene-causing-hypocalcaemia-case-report-of-a-father-and-two-sons
#18
M K Schoutteten, B Bravenboer, S Seneca, K Stouffs, B Velkeniers
BACKGROUND: Regulation of calcium is mediated by parathyroid hormone (PTH) and 1.25-dihydroxyvitamine D3. The calcium-sensing receptor (CaSR) regulates PTH release by a negative feedback system. Gain-of-function mutations in the CaSR gene reset the calcium-PTH axis, leading to hypocalcaemia. PATIENTS AND METHODS: We analysed a family with hypocalcaemia. The proband was a 47-year-old man (index, patient I1), who presented with paraesthesias in both limbs. He has two sons (patient II1 a nd I I2)...
July 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28740409/hair-follicle-growth-by-stromal-vascular-fraction-enhanced-adipose-transplantation-in-baldness
#19
David Perez-Meza, Craig Ziering, Marcos Sforza, Ganesh Krishnan, Edward Ball, Eric Daniels
Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10-15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Festa et al, in 2011, reported that adipocyte lineage cells support the stem cell niche and help drive the complex hair growth cycle...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28739772/efficacy-and-safety-of-nab-paclitaxel-as-second-line-chemotherapy-for-locally-advanced-and-metastatic-non-small-cell-lung-cancer
#20
Wenjing Gong, Ping Sun, Zhengbin Mu, Jiannan Liu, Caiyan Yu, Aina Liu
AIM: To investigate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for locally advanced or metastatic non-small cell lung cancer (NSCLC) as second-line chemotherapy. PATIENTS AND METHODS: We retrospectively reviewed the treatment of 34 patients with advanced NSCLC whose first-line treatment had failed. These patients received nab-paclitaxel 260 mg/m(2) on day 1 and day 8 of a 21-day cycle from July 2014 to February 2016. One cycle of treatment lasted 3 weeks and all patients completed more than two cycles...
August 2017: Anticancer Research
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