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https://www.readbyqxmd.com/read/28530675/reevaluation-of-snp-heritability-in-complex-human-traits
#1
Doug Speed, Na Cai, Michael R Johnson, Sergey Nejentsev, David J Balding
SNP heritability, the proportion of phenotypic variance explained by SNPs, has been reported for many hundreds of traits. Its estimation requires strong prior assumptions about the distribution of heritability across the genome, but current assumptions have not been thoroughly tested. By analyzing imputed data for a large number of human traits, we empirically derive a model that more accurately describes how heritability varies with minor allele frequency (MAF), linkage disequilibrium (LD) and genotype certainty...
May 22, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28529085/variations-in-native-protein-glycation-and-plasma-antioxidants-in-several-birds-of-prey
#2
Tana Ingram, Jessica Zuck, Chad R Borges, Patrick Redig, Karen L Sweazea
Birds are an anomaly among vertebrates as they are remarkably long-lived despite having naturally high blood glucose and metabolic rates. For mammals, hyperglycemia leads to oxidative stress and protein glycation. In contrast, many studies have shown that domestic and wild birds are relatively resistant to these glucose-mediated pathologies. Surprisingly very little research has examined protein glycation in birds of prey, which by nature consume a diet high in protein and fat that promotes gluconeogenesis...
May 18, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28525718/on-the-stability-of-the-parent-anion-of-the-potential-radiosensitizer-8-bromoadenine-formed-by-low-energy-3-ev-electron-attachment
#3
Robin Schürmann, Katrin Tanzer, Iwona Dabkowska, Stephan Paul Denifl, Ilko Bald
8-Bromoadenine (8BrA) is a potential DNA radiosensitizer for cancer radiation therapy due to its efficient interaction with low energy electrons (LEEs). LEEs are a short-living species generated during the radiation damage of DNA by high energy radiation as it is applied in cancer radiation therapy. Electron attachment to 8BrA in the gas phase results in a stable parent anion below 3 eV electron energy in addition to fragmentation products formed by resonant exocyclic bond cleavages. Density functional theory (DFT) calculations of the 8BrA- anion reveal an exotic bond between the bromine and the C8 atom with a bond length of 2...
May 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28500509/observations-of-termitarium-geophagy-by-rylands-bald-faced-saki-monkeys-pithecia-rylandsi-in-madre-de-dios-peru
#4
Dara B Adams, Jennifer A Rehg, Mrinalini Watsa
Geophagy, or soil consumption, has been documented in diverse animal taxa, including many primates. Physiological functions such as mineral supplementation, detoxification of secondary compounds, and antacid properties are possible causes for this behavior. We report on observations of geophagy at arboreal termitaria by free-ranging Pithecia rylandsi at La Estación Biológica Los Amigos (EBLA) in Perú between 2008 and 2015. Characteristics of geophagy events, including saki monkey behavior at the termitaria, were recorded and geochemical analyses were conducted on consumed termitaria, nearby topsoils, and unvisited termitaria...
May 12, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28500043/potential-for-water-borne-and-invertebrate-transmission-of-west-nile-virus-in-the-great-salt-lake-utah
#5
Melissa Lund, Valerie Shearn-Bochsler, Robert J Dusek, Jan Shivers, Erik Hofmeister
In November and December of 2013, a large mortality event involving 15,000 - 20,000 eared grebes (Podiceps nigricollis) occurred at the Great Salt Lake (GSL), UT. The onset of the outbreak in grebes was followed by a mortality event in > 86 bald eagles (Haliaeetus leucocephalus). During the die-off, West Nile virus (WNV) was detected by RT-PCR or viral culture in carcasses of grebes and eagles submitted to the National Wildlife Health Center. However, no mosquito activity, the primary vector of WNV, was detected by the State of Utah's WNV monitoring program...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28484599/to-migrate-stay-put-or-wander-varied-movement-strategies-in-bald-eagles-haliaeetus-leucocephalus
#6
Rachel E Wheat, Stephen B Lewis, Yiwei Wang, Taal Levi, Christopher C Wilmers
BACKGROUND: Quantifying individual variability in movement behavior is critical to understanding population-level patterns in animals. Here, we explore intraspecific variation in movement strategies of bald eagles (Haliaeetus leucocephalus) in the north Pacific, where there is high spatiotemporal resource variability. We tracked 28 bald eagles (five immature, 23 adult) using GPS transmitters between May 2010 and January 2016. RESULTS: We found evidence of four movement strategies among bald eagles in southeastern Alaska and western Canada: breeding individuals that were largely sedentary and remained near nest sites year-round, non-breeding migratory individuals that made regular seasonal travel between northern summer and southern winter ranges, non-breeding localized individuals that displayed fidelity to foraging sites, and non-breeding nomadic individuals with irregular movement...
2017: Movement Ecology
https://www.readbyqxmd.com/read/28476314/the-edinburgh-modification-of-the-minimal-access-zygomatic-osteotomy-used-for-the-correction-of-zygomatic-orbital-hypoplasia
#7
J N Philip, D F Campbell
Zygomatic hypoplasia can be an exceedingly difficult proposition for the surgeon treating facial deformity. The classical approach would be a coronal access, which is time-consuming, leaves a long scar on the scalp that shows in patients with balding patterns, and carries the risk of permanent facial weakness. The Edinburgh technique presents a minimal access approach to the zygomatic osteotomy. This is performed through local incisions and a bone cut made using hand-held diamond-coated wire that mobilizes the entire zygoma...
May 2, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28474633/echocardiographic-abnormalities-in-cirrhosis-their-correlation-with-severity-of-cirrhosis-using-child-pugh-score-among-patients-in-a-tertiary-care-hospital
#8
Jagruti Balde, N Karthik Rao, Kirthinath Ballala, Jyothi Samanth, K Ranjan Shetty, Navin Patil, A Avinash, George Varghese
BACKGROUND & OBJECTIVES: Child-Pugh score (CPS) is a widely used prognostic marker in cases of cirrhosis and pulmonary arterial hypertension (PAH). However, the role of this score in the quantification of severity of PAH is not well studied. In mild cases, echocardiography is more sensitive. This study was done to assess the association between echocardiography and severity of cirrhosis using CPS. METHODS: A cross-sectional study was done from April to June 2014 in 42 patients with cirrhosis using a pre-tested semi-structured interview schedule...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28471956/reduced-maternal-calcium-intake-through-nutrition-and-supplementation-is-associated-with-adverse-conditions-for-both-the-women-and-their-infants-in-a-chinese-population
#9
Xiaohong Liu, Xinjia Wang, Yue Tian, Zhixin Yang, Li Lin, Qing Lin, Zhonghao Zhang, Li Li
Effective nutritional guidelines for pregnant women in China are lacking. The aim of this study was to investigate the effect of dietary nutrition on the health condition of pregnant women and infants in China.In total, 331 pregnant women who had prenatal examinations were included in this study. Data, including dietary nutrition questionnaires, the weight, height, age, and health condition of the pregnant women as well as the health condition of the infants, were recorded.The average intake of milk, poultry and meat, fish and prawns, eggs, and bean products were 297...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28471070/performing-a-preliminary-hazard-analysis-applied-to-administration-of-injectable-drugs-to-infants
#10
Nadia Hfaiedh, Sofiane Kabiche, Catherine Delescluse, Issa-Bella Balde, Sophie Merlin, Sandra Carret, Loïc de Pontual, Jean-Eudes Fontan, Joël Schlatter
RATIONALE, AIMS AND OBJECTIVES: Errors in hospitals during the preparation and administration of intravenous drugs to infants and children have been reported to a rate of 13% to 84%. This study aimed to investigate the potential for hazardous events that may lead to an accident for preparation and administration of drug injection in a pediatric department and to describe a reduction plan of risks. METHODS: The preliminary hazard analysis (PHA) method was implemented by a multidisciplinary working group over a period of 5 months (April-August 2014) in infants aged from 28 days to 2 years...
May 4, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28423200/cd80cd86-deficiency-disrupts-regulatory-cd4-foxp3-t-cell-homeostasis-and-induces-autoimmune-like-alopecia
#11
Ji-Hyun Bae, Woo-Sung Hwang, Yoo-Jin Jang, Yoon-Hoo Lee, Da-Eun Jang, Jung-Sik Kim, Su-Cheong Yeom
Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86(-/-) ) mice. Incidence and severity of alopecia were analyzed in 58 B6.CD80CD86(-/-) mice by using histological examination, flow cytometry, multiplex enzyme-linked immunosorbent assay, quantitative RT-PCR, and CD25 inhibition test. Both male and female B6...
April 19, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28422407/mutations-in-tgds-associated-with-additional-malformations-of-the-middle-fingers-and-halluces-atypical-catel-manzke-syndrome-in-a-fetus
#12
Katharina Schoner, Rainer Bald, Denise Horn, Helga Rehder, Uwe Kornak, Nadja Ehmke
Pierre-Robin sequence, radial deviation, and ulnar clinodactyly of the index fingers due to an additional phalangeal bone, as well as heart defects are the key features of Catel-Manzke syndrome. Although mutations in TGDS were identified as the cause of this disorder, the pathogenetic mechanism remains unknown. Here, we report on a fetus with severe heart defect, nuchal edema, talipes, Pierre-Robin sequence, and bilateral deviation and clinodactyly of the index and middle fingers. Pregnancy was terminated at the 22nd week of gestation...
April 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28419572/genome-wide-differential-expression-profiling-of-long-non-coding-rnas-in-androgenetic-alopecia-in-a-chinese-male-population
#13
Linlin Bao, Aijiao Yu, Yaojia Luo, Tian Tian, Yuxi Dong, Haifeng Zong, Hongduo Chen, Xinghua Gao, Xuegang Xu, Yuanhong Li
BACKGROUND: Androgenetic alopecia (AGA), or male pattern baldness (MPB), is the most common form of hair loss in males. A combination of genetic and androgen causes have been suggested as factors that contribute to the development of AGA. However, the specific molecular mechanisms that underly AGA remain largely unknown. Long noncoding RNAs (lncRNAs), a new class of regulatory noncoding RNAs that are longer than 200 nucleotides, have been shown to play important roles in a number of cellular processes, including transcription, chromosome remodelling, and posttranscriptional processing...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28403520/study-of-gene-expression-alteration-in-male-androgenetic-alopecia-evidence-of-predominant-molecular-signaling-pathways
#14
L Michel, P Reygagne, P Benech, F Jean-Louis, S Scalvino, S Ly Ka So, Z Hamidou, S Bianovici, J Pouch, B Ducos, M Bonnet, A Bensussan, A Patatian, E Lati, J Wdzieczak-Bakala, J-C Choulot, E Loing, M Hocquaux
BACKGROUND: Male androgenetic alopecia (AGA) is the most common form of hair loss in men and is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for AGA remain to be defined. OBJECTIVES: Herein, molecular biomarkers associated with premature AGA were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless/bald men with premature AGA and healthy volunteers...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28400527/targeting-energy-metabolism-in-mycobacterium-tuberculosis-a-new-paradigm-in-antimycobacterial-drug-discovery
#15
REVIEW
Dirk Bald, Cristina Villellas, Ping Lu, Anil Koul
Drug-resistant mycobacterial infections are a serious global health challenge, leading to high mortality and socioeconomic burdens in developing countries worldwide. New innovative approaches, from identification of new targets to discovery of novel chemical scaffolds, are urgently needed. Recently, energy metabolism in mycobacteria, in particular the oxidative phosphorylation pathway, has emerged as an object of intense microbiological investigation and as a novel target pathway in drug discovery. New classes of antibacterials interfering with elements of the oxidative phosphorylation pathway are highly active in combating dormant or latent mycobacterial infections, with a promise of shortening tuberculosis chemotherapy...
April 11, 2017: MBio
https://www.readbyqxmd.com/read/28372367/fast-piezoelectric-valve-offering-controlled-gas-injection-in-magnetically-confined-fusion-plasmas-for-diagnostic-and-fuelling-purposes
#16
M Griener, O Schmitz, K Bald, D Bösser, M Cavedon, P De Marné, T Eich, G Fuchert, A Herrmann, A Kappatou, T Lunt, V Rohde, B Schweer, M Sochor, U Stroth, A Terra, E Wolfrum
In magnetically confined fusion plasmas controlled gas injection is crucial for plasma fuelling as well as for various diagnostic applications such as active spectroscopy. We present a new, versatile system for the injection of collimated thermal gas beams into a vacuum chamber. This system consists of a gas pressure chamber, sealed by a custom made piezo valve towards a small capillary for gas injection. The setup can directly be placed inside of the vacuum chamber of fusion devices as it is small and immune against high magnetic fields...
March 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28370750/dyslipidemia-after-pediatric-renal-transplantation-the-impact-of-immunosuppressive-regimens
#17
Sandra Habbig, Ruth Volland, Kai Krupka, Uwe Querfeld, Luca Dello Strologo, Aytül Noyan, Fatos Yalcinkaya, Rezan Topaloglu, Nicholas J A Webb, Markus J Kemper, Lars Pape, Martin Bald, Birgitta Kranz, Christina Taylan, Britta Höcker, Burkhard Tönshoff, Lutz T Weber
Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Data were obtained before and during the first year after RTx to analyze possible non-modifiable and modifiable risk factors. The prevalence of dyslipidemia was 95% before engraftment and 88% at 1 year post-transplant...
May 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28355494/potential-methane-emission-reductions-for-two-manure-treatment-technologies
#18
Andrew VanderZaag, Hambaliou Baldé, Anna Crolla, Robert J Gordon, Martin Ngwabie, Claudia Wagner-Riddle, Ray Desjardins, Doug MacDonald
The biochemical methane potential (BMP) of manure is needed to predict CH4 emissions from stored livestock manure and to assess emission mitigation techniques. This study evaluated the effect of two dairy manure treatments, solid-liquid separation (SLS) and anaerobic digestion (AD), on methane potential and the speed of production. Assays were performed in the lab to measure methane (CH4) production over 202 d from dairy manure samples taken before and after each treatment. Compared to raw manure, CH4 emissions on a per-L basis were reduced 81% by SLS and 59% by AD, on average...
March 29, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28349362/androgenetic-alopecia-a-review
#19
REVIEW
Francesca Lolli, Francesco Pallotti, Alfredo Rossi, Maria C Fortuna, Gemma Caro, Andrea Lenzi, Andrea Sansone, Francesco Lombardo
PURPOSE: Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism of androgenetic alopecia. METHODS: Using the PubMed database, we conducted a systematic review of the literature, selecting studies published from 1916 to 2016. RESULTS: The occurrence and development of androgenetic alopecia depends on the interaction of endocrine factors and genetic predisposition...
March 28, 2017: Endocrine
https://www.readbyqxmd.com/read/28346212/stability-of-extemporaneously-prepared-hydroxycarbamide-oral-suspensions
#20
Djamila Kabiche, Issa-Bella Balde, Elyes Majoul, Sofiane Kabiche, Elodie Bourguignon, Jean-Eudes Fontan, Salvatore Cisternino, Jöel Schlatter
Hydroxycarbamide, available as tablets, is a pharmacological agent for fetal hemoglobin induction such as sickle cell anemia. The need for alternative dosage form options for patients unable to take tablets led hospital pharmacies to prepare solutions and suspensions. The objective of this study was to determine the stability of hydroxycarbamide in Ora-Plus in combination with either Ora-Sweet or Ora-Sweet SF, Ora-Blend, or Ora-Blend SF suspending agents. The studied samples were compounded into 100-mg/mL suspensions and stored in 60-mL amber glass bottles at room (22°C to 25°C) or refrigerated (4°C to 8°C) temperature...
March 2017: International Journal of Pharmaceutical Compounding
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