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https://www.readbyqxmd.com/read/28446002/effects-of-fungal-lentinussajor-caju-treated-oil-palm-frond-on-performance-and-carcass-characteristics-in-finishing-goats
#1
Pin Chanjula, Vasun Petcharat, Anusorn Cherdthong
OBJECTIVE: This experiment was conducted to investigate the effects of fungal treated oil palm fronds (FTOPF) on performance, carcass traits, meat quality, and muscle chemical composition. METHODS: Eighteen growing crossbred male goats (Thai Native×Anglo Nubian) with 18.7±2.0 kg of initial body weight (BW) were stratified and blocked by BW in a randomized complete block design. Three diets containing 30% of oil palm fronds (OPF) either untreated (UOPF) or treated with Lentinussajor-caju (FTOPF) with or without urea (FTOPFU) were used as roughage sources in total mixed rations (TMRs)...
June 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28445811/liraglutide-a-glp-1-receptor-agonist-inhibits-vascular-smooth-muscle-cell-proliferation-by-enhancing-amp-activated-protein-kinase-and-cell-cycle-regulation-and-delays-atherosclerosis-in-apoe-deficient-mice
#2
Teruo Jojima, Kohsuke Uchida, Kazumi Akimoto, Takanori Tomotsune, Kazunori Yanagi, Toshie Iijima, Kunihiro Suzuki, Kikuo Kasai, Yoshimasa Aso
BACKGROUND AND AIMS: Several studies have demonstrated that both native glucagon-like peptide-1 (GLP-1) and GLP-1 receptor agonists suppress the progression of atherosclerosis in animal models. METHODS: We investigated whether liraglutide, a GLP-1 analogue, could prevent the development of atherosclerosis in apolipoprotein E knockout mice (ApoE(-/-)) on a high-fat diet. We also examined the influence of liraglutide on angiotensin II-induced proliferation of rat vascular smooth muscle cells (VSMCs) via enhancement of AMP-activated protein kinase (AMPK) signaling and regulation of cell cycle progression...
April 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28445803/jetvalve-rapid-manufacturing-of-biohybrid-scaffolds-for-biomimetic-heart-valve-replacement
#3
Andrew K Capulli, Maximillian Y Emmert, Francesco S Pasqualini, Debora Kehl, Etem Caliskan, Johan U Lind, Sean P Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber, Josue A Goss, Simon P Hoerstrup, Kevin Kit Parker
Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. To overcome these limitations, in situ tissue engineering approaches aim to develop scaffold materials and manufacturing processes that elicit endogenous tissue remodeling and repair. Yet despite recent advances in synthetic materials manufacturing, there remains a lack of cell-free, automated approaches for rapidly producing biomimetic heart valve scaffolds...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28445784/brain-potentials-predict-language-selection-before-speech-onset-in-bilinguals
#4
Yan Jing Wu, Guillaume Thierry
Studies of language production in bilinguals have seldom considered the fact that language selection likely involves proactive control. Here, we show that Chinese-English bilinguals actively inhibit the language not-to-be used before the onset of a picture to be named. Depending on the nature of a directive cue, participants named a subsequent picture in their native language, in their second language, or remained silent. The cue elicited a contingent negative variation of event-related brain potentials, greater in amplitude when the cue announced a naming trial as compared to when it announced a silent trial...
April 23, 2017: Brain and Language
https://www.readbyqxmd.com/read/28445752/refolding-of-sds-unfolded-proteins-by-nonionic-surfactants
#5
Jørn Døvling Kaspersen, Anne Søndergaard, Daniel Jhaf Madsen, Daniel E Otzen, Jan Skov Pedersen
The strong and usually denaturing interaction between anionic surfactants (AS) and proteins/enzymes has both benefits and drawbacks: for example, it is put to good use in electrophoretic mass determinations but limits enzyme efficiency in detergent formulations. Therefore, studies of the interactions between proteins and AS as well as nonionic surfactants (NIS) are of both basic and applied relevance. The AS sodium dodecyl sulfate (SDS) denatures and unfolds globular proteins under most conditions. In contrast, NIS such as octaethylene glycol monododecyl ether (C12E8) and dodecyl maltoside (DDM) protect bovine serum albumin (BSA) from unfolding in SDS...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445749/equilibrium-ensembles-for-insulin-folding-from-bias-exchange-metadynamics
#6
Richa Singh, Rohit Bansal, Anurag Singh Rathore, Gaurav Goel
Earliest events in the aggregation process, such as single molecule reconfiguration, are extremely important and the most difficult to characterize in experiments. To this end, we have used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. A bin-based clustering method that uses statistics accumulated in bias exchange metadynamics trajectories was employed to construct a detailed thermodynamic and kinetic model of insulin folding...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445514/the-complexity-underlying-invasiveness-precludes-the-identification-of-invasive-traits-a-comparative-study-of-invasive-and-non-invasive-heterocarpic-atriplex-congeners
#7
Jana Doudová, Jan Douda, Bohumil Mandák
Heterocarpy enables species to effectively spread under unfavourable conditions by producing two or more types of fruit differing in ecological characteristics. Although it is frequent in annuals occupying disturbed habitats that are vulnerable to invasion, there is still a lack of congeneric studies addressing the importance of heterocarpy for species invasion success. We compared two pairs of heterocarpic Atriplex species, each of them comprising one invasive and one non-invasive non-native congener. In two common garden experiments, we (i) simulated the influence of different levels of nutrients and population density on plants grown from different types of fruits and examined several traits that are generally positively associated with invasion success, and (ii) grew plants in a replacement series experiment to evaluate resource partitioning between them and to compare their competitive ability...
2017: PloS One
https://www.readbyqxmd.com/read/28445505/dominance-of-an-alien-shrub-rhus-typhina-over-a-native-shrub-vitex-negundo-var-heterophylla-under-variable-water-supply-patterns
#8
Ning Du, Xiangfeng Tan, Qiang Li, Xiao Liu, Wenxin Zhang, Renqing Wang, Jian Liu, Weihua Guo
Temporal heterogeneity of a resource supply can have a profound effect on the interactions between alien and native plant species and their potential invasiveness. Precipitation patterns may be variable and result in a higher heterogeneity of water supply with global climate change. In this study, an alien shrub species, Rhus typhina, introduced to China from North America and a native shrub species, Vitex negundo var. heterophylla, were grown in monoculture and mixed culture under different water supply regimes, with four levels of water supply frequencies but with a constant level of total supplied water...
2017: PloS One
https://www.readbyqxmd.com/read/28445435/microarray-selection-of-cooperative-peptides-for-modulating-enzyme-activities
#9
Jinglin Fu
Recently, peptide microarrays have been used to distinguish proteins, antibodies, viruses, and bacteria based on their binding to random sequence peptides. We reported on the use of peptide arrays to identify enzyme modulators that involve screening an array of 10,000 defined and addressable peptides on a microarray. Primary peptides were first selected to inhibit the enzyme at low μM concentrations. Then, new peptides were found to only bind strongly with the enzyme-inhibitor complex, but not the native enzyme...
April 26, 2017: Microarrays
https://www.readbyqxmd.com/read/28445431/assessing-diabetes-and-factors-associated-with-foregoing-medical-care-among-persons-with-diabetes-disparities-facing-american-indian-alaska-native-black-hispanic-low-income-and-southern-adults-in-the-u-s-2011-2015
#10
Samuel D Towne, Jane Bolin, Alva Ferdinand, Emily Joy Nicklett, Matthew Lee Smith, Marcia G Ory
Objective: Identify individual- and place-based factors associated with diagnosed diabetes and forgone medical care among those diagnosed with diabetes. Background: Diabetes affects millions of individuals globally. In the U.S. alone the prevalence rate of diagnosed diabetes has more than doubled over the past 20 years (4.2% in 1994 to 10% in 2014). Methods: The Behavioral Risk Factor Surveillance System (2011-2015) was used to identify factors associated with self-reported diabetes diagnoses (ever diagnosed) among U...
April 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28445413/identification-of-highly-specific-scfvs-against-total-adiponectin-for-diagnostic-purposes
#11
Peter Wilton, Michael Steidel, Gabriele Krczal, Iris Hermanns, Andreas Pfützner, Alisa Konnerth, Kajohn Boonrod
Adiponectin is one of the most abundant adipokines secreted from adipose tissue. It acts as an endogenous insulin sensitizer and plasma concentrations are inversely correlated with obesity and metabolic syndrome. A decrease in plasma adiponectin levels normally indicates increased hormonal activity of the visceral lipid tissue, which is associated with decreased insulin sensitivity. It may therefore be considered a valuable biomarker for elucidating the underlying deteriorations resulting in type 2 diabetes and macrovascular disease...
April 26, 2017: Biology
https://www.readbyqxmd.com/read/28445366/biomechanical-integrity-in-craniofacial-surgery-calvarial-reconstruction-in-favorable-and-infected-defects-with-bone-morphogenetic-protein-2
#12
Zoe M MacIsaac, Sarah E Henderson, Sameer Shakir, Sanjay Naran, Darren M Smith, Liliana Camison, James J Cray, Alejandro J Almarza, Gregory M Cooper, Joseph E Losee
BACKGROUND: The limitations of autologous and alloplastic reconstruction for craniofacial bone defects have created a clinical need for viable tissue-engineering strategies. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has shown promise in this setting. The aim of this study was to determine the long-term biomechanical properties of rhBMP-2-mediated calvarial reconstruction. METHODS: Twelve-week-old New Zealand White rabbits underwent subtotal calvarectomy...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445200/the-nasal-tip-rotation-flap-for-reconstruction-of-the-lateral-nasal-tip-anterior-ala-and-soft-triangle-the-authors-experience-with-55-patients
#13
Anastasia Benoit, S Tyler Hollmig, Brian C Leach
BACKGROUND: Defects of the lateral nasal tip, anterior ala, and soft triangle subunits lack reconstructive options that are consistently satisfactory. For such defects, the novel anterior-based nasal tip rotation flap provides functional and aesthetic results in a single operative session. OBJECTIVE: To describe the authors' experience with the nasal tip rotation flap, including patient selection and design modifications to enhance aesthetic success. METHODS: An IRB-approved retrospective database review of nasal tip rotation flap repairs was performed at the Medical University of South Carolina and Stanford University Medical Center...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28445000/vegetation-response-to-control-of-invasive-tamarix-in-southwestern-us-rivers-a-collaborative-study-including-416-sites
#14
Eduardo González, Anna A Sher, Robert M Anderson, Robin F Bay, Daniel W Bean, Gabriel J Bissonnete, Bérenger Bourgeois, David J Cooper, Kara Dohrenwend, Kim D Eichhorst, Hisham El Waer, Deborah K Kennard, Rebecca Harms-Weissinger, Annie L Henry, Lori J Makarick, Steven M Ostoja, Lindsay V Reynolds, W Wright Robinson, Patrick B Shafroth
Most studies assessing vegetation response following control of invasive Tamarix trees along southwestern U.S. rivers have been small in scale (e.g., river reach), or at a regional scale but with poor spatial-temporal replication, and most have not included testing the effects of a now widely-used biological control. We monitored plant composition following Tamarix control along hydrologic, soil and climatic gradients in 244 treated and 172 reference sites across six U.S. States. This represents the largest comprehensive assessment to date on the vegetation response to the four most common Tamarix control treatments...
April 26, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28444907/plant-reproduction-is-altered-by-simulated-herbicide-drift-to-constructed-plant-communities
#15
David Olszyk, Thomas Pfleeger, Tamotsu Shiroyama, Matthew Blakeley-Smith, E Henry Lee, Milton Plocher
Herbicide drift may have unintended impacts on native vegetation, adversely affecting individual species and plant communities. To determine potential ecological effects of herbicide drift, small plant community plots were constructed using nine perennial species found in different Willamette Valley Oregon grassland habitats. Studies were conducted at two Oregon State University farms in two separate years, with single and combined treatments of 0.01 to 0.2 x field application rates (f.a.r.) of 1119 g ha(-1) for glyphosate [active ingredient (a...
April 26, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28444814/chronic-antibody-mediated-rejection-in-nonhuman-primate-renal-allografts-validation-of-human-histological-and-molecular-phenotypes
#16
B A Adam, R N Smith, I A Rosales, M Matsunami, B Afzali, T Oura, A B Cosimi, T Kawai, R B Colvin, M Mengel
Molecular testing represents a promising adjunct for the diagnosis of antibody-mediated rejection (AMR). Here we apply a novel gene expression platform in sequential formalin-fixed paraffin-embedded (FFPE) samples from nonhuman primate (NHP) renal transplants. We analyzed 34 previously-described gene transcripts related to AMR in humans in 197 archival NHP samples, including 102 from recipients that developed chronic AMR, 80 from recipients without AMR, and 15 normal native nephrectomies. Three endothelial genes (VWF, DARC, CAV1), derived from 10-fold cross-validation ROC curve analysis, demonstrated excellent discrimination between AMR and non-AMR samples (AUC=0...
April 26, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28444679/membranes-derived-from-human-umbilical-cord-wharton-s-jelly-stem-cells-as-novel-bioengineered-tissue-like-constructs
#17
B D Jaimes-Parra, I Garzón, V Carriel, D Durand-Herrera, M A Martín-Piedra, J M García, M C Sánchez-Quevedo, M Alaminos, A Campos
Cell-derived matrices were recently described as novel biomaterials generated by human cells allowed to grow and synthetize their own extracellular matrix in culture. In the present work, we generated and evaluated a novel tissue-like substitute (WDM) consisting of a membrane derived from cultured human Wharton's jelly stem cells. WDM were evaluated ex vivo and in vivo by histochemistry and immunohistochemistry for several mesenchymal cell markers and fibrillar and non-fibrillar extracellular matrix components...
April 26, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28444629/stress-measured-by-allostatic-load-score-varies-by-reason-for-immigration-the-africans-in-america-study
#18
Jean N Utumatwishima, Rafeal L Baker, Brianna A Bingham, Stephanie T Chung, David Berrigan, Anne E Sumner
OBJECTIVE: Reason for immigration as a biological stress has not been studied in Africans. Our goal was to determine in African immigrants, if biological stress measured by allostatic load score (ALS) varies by reason for immigration. METHODS: Using an ALS which had been previously developed with the National Health and Nutrition Examination Survey (NHANES) data to assess stress due to racism and nativity, ALS was calculated in 85 African immigrants (67% male, age 42 ± 10 years)...
April 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28444627/level-of-cigarette-consumption-and-duration-of-smoking-abstinence-during-failed-quit-attempts-among-long-term-daily-smokers-the-role-of-race-ethnicity-and-cessation-aids
#19
Julia N Soulakova, Lisa J Crockett
The goal of this study was to determine whether race/ethnicity and use of smoking cessation aids are associated with the duration of the last serious quit attempt and reductions in cigarette consumption among long-term daily smokers who tried, and failed, to quit smoking during the preceding year. Data came from the 2010-2011 Tobacco Use Supplement survey conducted in the USA, and analyses included 6672 reports of long-term daily smokers (i.e., smokers who smoked daily for 1 year or longer) who made at least one serious quit attempt in the past 12 months...
April 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28444615/polygenic-study-of-endurance-associated-genetic-markers-ace-i-d-actn3-arg-r-577ter-x-ckmm-a-g-ncoi-and-enos-glu-g-298asp-t-in-male-gorkha-soldiers
#20
Seema Malhotra, Kiran Preet, Arvind Tomar, Shweta Rawat, Sayar Singh, Inderjeet Singh, L Robert Varte, Tirthankar Chatterjee, M S Pal, Soma Sarkar
BACKGROUND: Gorkhas, a sub-mountainous population of the Himalayan region, are known for strength and bravery. In the present study when "Gorkha" is used without brackets, we are mentioning Gorkhas of Tibeto-Burman origin. Physical capability, strength and endurance are important components of fitness associated with genetic traits. The aim of this study was to examine the endurance potential of male Gorkha soldiers, based on endurance-related genetic markers ACE I/D, ACTN3 Arg (R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T)...
December 2017: Sports Medicine—Open
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