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https://www.readbyqxmd.com/read/27906041/implementation-of-the-better-2-program-a-qualitative-study-exploring-barriers-and-facilitators-of-a-novel-way-to-improve-chronic-disease-prevention-and-screening-in-primary-care
#1
Nicolette Sopcak, Carolina Aguilar, Mary Ann O'Brien, Candace Nykiforuk, Kris Aubrey-Bassler, Richard Cullen, Eva Grunfeld, Donna Patricia Manca
BACKGROUND: BETTER (Building on Existing Tools to Improve Chronic Disease Prevention and Screening in Primary Care) is a patient-based intervention to improve chronic disease prevention and screening (CDPS) for cardiovascular disease, diabetes, cancer, and associated lifestyle factors in patients aged 40 to 65. The key component of BETTER is a prevention practitioner (PP), a health care professional with specialized skills in CDPS who meets with patients to develop a personalized prevention prescription, using the BETTER toolkit and Brief Action Planning...
December 1, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27885721/physicochemical-and-electronic-properties-of-cationic-6-helicenes-from-chemical-and-electrochemical-stabilities-to-far-red-polarized-luminescence
#2
Johann Bosson, Geraldine M Labrador, Simon Pascal, François-Alexandre Miannay, Oleksandr Yushchenko, Haidong Li, Laurent Bouffier, Neso Sojic, Roberto C Tovar, Gilles Muller, Denis Jacquemin, Adèle D Laurent, Boris Le Guennic, Eric Vauthey, Jérôme Lacour
The physicochemical properties of cationic dioxa (1), azaoxa (2), and diaza (3) [6]helicenes demonstrate a much higher chemical stability of the diaza adduct 3 (pKR+ =20.4, Ered1/2 =-0.72 V) compared to its azaoxa 2 (pKR+ =15.2, Ered1/2 =-0.45 V) and dioxa 1 (pKR+ =8.8, Ered1/2 =-0.12 V) analogues. The fluorescence of these cationic chromophores is established, and ranges from the orange to the far-red regions. From 1 to 3, a bathochromic shift of the lowest energy transitions (up to 614 nm in acetonitrile) and an enhancement of the fluorescence quantum yields and lifetimes (up to 31 % and 9...
November 25, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27883930/reconciling-community-based-indigenous-research-and-academic-practices-knowing-principles-is-not-always-enough
#3
Melody E Morton Ninomiya, Nathaniel J Pollock
Historically, Indigenous health research in Canada has failed to engage Indigenous peoples and communities as primary stakeholders of research evidence. Increasingly, research ethics and methodologies are being positioned as tools for Indigenous self-determination. In response, mainstream institutions have developed new ethical principles for research involving Indigenous people. While these transformations are necessary steps towards re-orienting research practices, they are not prescriptive. In this paper, we make visible three dilemmas from a case study in which Indigenous health research frameworks provided limited guidance or were unclear about how to balance community priorities with Indigenous research principles...
November 5, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27881602/n-terminal-acetylation-promotes-synaptonemal-complex-assembly-in-c-elegans
#4
Jinmin Gao, Consuelo Barroso, Pan Zhang, Hyun-Min Kim, Shangtong Li, Leticia Labrador, James Lightfoot, Maxim V Gerashchenko, Vyacheslav M Labunskyy, Meng-Qiu Dong, Enrique Martinez-Perez, Monica P Colaiácovo
N-terminal acetylation of the first two amino acids on proteins is a prevalent cotranslational modification. Despite its abundance, the biological processes associated with this modification are not well understood. Here, we mapped the pattern of protein N-terminal acetylation in Caenorhabditis elegans, uncovering a conserved set of rules for this protein modification and identifying substrates for the N-terminal acetyltransferase B (NatB) complex. We observed an enrichment for global protein N-terminal acetylation and also specifically for NatB substrates in the nucleus, supporting the importance of this modification for regulating biological functions within this cellular compartment...
November 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/27875090/clinical-computed-tomographic-magnetic-resonance-imaging-and-histologic-findings-associated-with-myxomatous-neoplasia-of-the-temporomandibular-joint-in-two-dogs
#5
Arana Parslow, David P Taylor, David J Simpson
CASE DESCRIPTION A 15-year-old neutered female mixed-breed dog (dog 1) and an 11-year-old neutered female Labrador Retriever (dog 2) were examined because of unilateral exophthalmus, third eyelid protrusion, and periorbital swelling that failed to respond to antimicrobial treatment. CLINICAL FINDINGS Both dogs underwent ultrasonographic, CT, and MRI examination of the head. In both dogs, advanced imaging revealed a poorly defined, peripherally contrast-enhancing, mucous-filled cystic mass that radiated from the temporomandibular joint and infiltrated the periorbital tissues and retrobulbar space...
December 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27865756/association-of-insulin-dosage-with-mortality-or-major-adverse-cardiovascular-events-a-retrospective-cohort-study
#6
John-Michael Gamble, Eugene Chibrikov, Laurie K Twells, William K Midodzi, Stephanie W Young, Don MacDonald, Sumit R Majumdar
BACKGROUND: Existing studies have shown conflicting evidence regarding the safety of exogenous insulin therapy in patients with type 2 diabetes. In particular, observational studies have reported an increased risk of death and cardiovascular disease among users of higher versus lower doses of insulin. We aimed to quantify the association between increasing dosage of insulin exposure and death and cardiovascular events, while taking into account time-dependent confounding and mediation that might have biased previous studies...
November 16, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27862377/merging-pedigree-databases-to-describe-and-compare-mating-practices-and-gene-flow-between-pedigree-dogs-in-france-sweden-and-the-uk
#7
S Wang, G Leroy, S Malm, T Lewis, E Strandberg, W F Fikse
Merging pedigree databases across countries may improve the ability of kennel organizations to monitor genetic variability and health-related issues of pedigree dogs. We used data provided by the Société Centrale Canine (France), Svenska Kennelklubben (Sweden) and the Kennel Club (UK) to study the feasibility of merging pedigree databases across countries and describe breeding practices and international gene flow within the following four breeds: Bullmastiff (BMA), English setter (ESE), Bernese mountain dog (BMD) and Labrador retriever (LBR)...
November 10, 2016: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/27859748/use-of-serum-micrornas-as-biomarker-for-hepatobiliary-diseases-in-dogs
#8
K Dirksen, T Verzijl, G C Grinwis, R P Favier, L C Penning, I A Burgener, L J van der Laan, H Fieten, B Spee
BACKGROUND: Current biochemical indicators cannot discriminate between parenchymal, biliary, vascular, and neoplastic hepatobiliary diseases. MicroRNAs are promising new biomarkers for hepatobiliary disease in humans and dogs. OBJECTIVE: To measure serum concentrations of an established group of microRNAs in dogs and to investigate their concentrations in various types of hepatobiliary diseases. ANIMALS: Forty-six client-owned dogs with an established diagnosis of hepatobiliary disease and stored serum samples and eleven client-owned healthy control Labrador Retrievers...
November 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27854338/selection-of-breeding-stock-among-australian-purebred-dog-breeders-with-particular-emphasis-on-the-dam
#9
Veronika Czerwinski, Michelle McArthur, Bradley Smith, Philip Hynd, Susan Hazel
Every year, thousands of purebred domestic dogs are bred by registered dog breeders. Yet, little is known about the rearing environment of these dogs, or the attitudes and priorities surrounding breeding practices of these dog breeders. The objective of this study was to explore some of the factors that dog breeders consider important for stock selection, with a particular emphasis on issues relating to the dam. Two-hundred and seventy-four Australian purebred dog breeders, covering 91 breeds across all Australian National Kennel Club breed groups, completed an online survey relating to breeding practices...
November 16, 2016: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/27853146/corrigendum-recent-increases-in-arctic-freshwater-flux-affects-labrador-sea-convection-and-atlantic-overturning-circulation
#10
Qian Yang, Timothy H Dixon, Paul G Myers, Jennifer Bonin, Don Chambers, M R van den Broeke, Mads H Ribergaard, John Mortensen
No abstract text is available yet for this article.
November 17, 2016: Nature Communications
https://www.readbyqxmd.com/read/27853047/long-term-management-of-a-dog-with-idiopathic-megaesophagus-and-recurrent-aspiration-pneumonia-by-use-of-an-indwelling-esophagostomy-tube-for-suction-of-esophageal-content-and-esophagogastric-tube-feeding
#11
Yuka Kanemoto, Kenjiro Fukushima, Hideyuki Kanemoto, Koichi Ohno, Hajime Tsujimoto
A 10-year-old neutered male Labrador Retriever dog was diagnosed with idiopathic megaesophagus. Despite receiving conventional treatments including elevated feeding, the dog showed repeated regurgitation and aspiration pneumonia, consequently developing weight loss and severe malnutrition. For the purpose of controlling regurgitation, an esophagostomy tube was placed for draining the esophageal fluid. Additionally, an esophagogastric tube was placed for nutritional support. After tube placement, the average frequency of regurgitation was reduced from 2...
November 17, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27824893/an-age-associated-decline-in-thymic-output-differs-in-dog-breeds-according-to-their-longevity
#12
Angela Holder, Stephanie Mella, Donald B Palmer, Richard Aspinall, Brian Catchpole
The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify signal joint T cell receptor excision circles (sj-TRECs), a method which has been developed and used in several mammalian species. Life expectancy and the rate of aging vary in dogs depending upon their breed. In this study, we quantified sj-TRECs in blood samples from dogs of selected breeds to determine whether there was a relationship between longevity and thymic output...
2016: PloS One
https://www.readbyqxmd.com/read/27807383/vascularized-pedicle-jejunal-graft-for-closure-of-large-duodenal-defect-in-a-dog
#13
Anna Massie, Michael McFadden
A Labrador retriever dog was presented for intestinal obstruction resulting in devitalization of portions of the duodenum. A severe perforation, accounting for 70% duodenal circumference, was present at the level of the duodenal papilla. A vascularized jejunal graft was used to close the perforation, representing novel utilization of this grafting technique.
November 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27797700/age-at-first-drink-experiences-of-drunkenness-and-alcohol-related-problems-in-canadian-youth-is-early-onset-bad-if-you-are-a-moderate-drinker
#14
Mark Asbridge, Jenny Cartwright, Kevin Wilson, Donald Langille
OBJECTIVE: This article examines early age at first drink (AFD) (14 years and younger) and alcohol-related problems, with a focus on experiences of drunkenness. It challenges the assumption that all early AFD is harmful by investigating whether early drinkers who typically consume alcohol in moderation experience minimal problems or harms. METHOD: Participants were drawn from the 2012 Student Drug Use Survey in Canada's Atlantic Provinces of New Brunswick, Nova Scotia, and Newfoundland and Labrador, an anonymous cross-sectional survey of high school students (ages 15-19 years)...
November 2016: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27793212/the-newfoundland-and-labrador-bariatric-surgery-cohort-study-rational-and-study-protocol
#15
Laurie K Twells, Deborah M Gregory, William K Midodzi, Carla Dillon, Christopher S Kovacs, Don MacDonald, Kendra K Lester, David Pace, Chris Smith, Darrell Boone, Raleen Murphy
BACKGROUND: In Canada, there has been a disproportionate increase in adults with Class II (BMI 35.0-39.9 kg/m(2)) or Class III obesity (BMI ≥ 40 kg/m(2)) affecting 9 % of Canadians with increases projected. Individuals affected by severe obesity (BMI ≥ 35) are at increased risk of high blood pressure, cardiovascular disease, diabetes, cancer, impaired quality of life, and premature mortality. Bariatric surgery is the most effective treatment for severe obesity. Laparoscopic sleeve gastrectomy (LSG), a relatively new type of bariatric surgery, is growing in popularity as a treatment...
October 28, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27790632/infodemiological-data-of-high-school-drop-out-related-web-searches-in-canada-correlating-with-real-world-statistical-data-in-the-period-2004-2012
#16
Anna Siri, Hicham Khabbache, Ali Al-Jafar, Mariano Martini, Francesco Brigo, Nicola Luigi Bragazzi
The present data article describes high-school drop-out related web activities in Canada, from 2004 to 2012, obtained mining Google Trends (GT), using high-school drop-out as key-word. The searches volumes were processed, correlated and cross-correlated with statistical data obtained at national and province level and broken down for gender. Further, an autoregressive moving-average (ARMA) model was used to model the GT-generated data. From a qualitative point of view, GT-generated relative search volumes (RSVs) reflect the decrease in drop-out rate...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27779885/following-in-real-time-the-two-step-assembly-of-nanoparticles-into-mesocrystals-in-levitating-drops
#17
Michael Agthe, Tomás S Plivelic, Ana Labrador, Lennart Bergström, German Salazar-Alvarez
Mesocrystals composed of crystallographically aligned nanocrystals are present in biominerals and assembled materials which show strongly directional properties of importance for mechanical protection and functional devices. Mesocrystals are commonly formed by complex biomineralization processes and can also be generated by assembly of anisotropic nanocrystals. Here, we follow the evaporation-induced assembly of maghemite nanocubes into mesocrystals in real time in levitating drops. Analysis of time-resolved small-angle X-ray scattering data and ex situ scanning electron microscopy together with interparticle potential calculations show that the substrate-free, particle-mediated crystallization process proceeds in two stages involving the formation and rapid transformation of a dense, structurally disordered phase into ordered mesocrystals...
October 31, 2016: Nano Letters
https://www.readbyqxmd.com/read/27777045/playful-activity-post-learning-improves-training-performance-in-labrador-retriever-dogs-canis-lupus-familiaris
#18
Nadja Affenzeller, Rupert Palme, Helen Zulch
Situations that are emotional and arousing have an effect on cognitive performance. It is thought that beta adrenergic activation and the release of stress hormones enhance memory consolidation and lead to an increase in memorability of emotional events. This beneficial effect has been shown in humans, non-human primates and rodents. Techniques which could enhance memory for learning specific tasks would be highly valuable, especially in dogs, which are extensively trained to aid humans. A pseudo-randomized, counterbalanced, between subject study designs was utilised and 16 Labrador Retrievers ranging from 1 to 9years of age were trained in a 2-choice discrimination paradigm...
January 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27767903/neurosurgical-sequelae-of-domestic-dog-attacks-in-children
#19
Ramesh Kumar, Frederic W B Deleyiannis, Corbett Wilkinson, Brent R O'Neill
OBJECTIVE The authors' goals in this study were to describe a series of dog attacks on children that required neurosurgical consultation and to better understand the pattern of injuries inflicted, the circumstances that place children at risk for attack, and the dog breeds involved. In addition, the authors review the surgical and medical management of these patients. METHODS The authors performed a retrospective review of all children requiring neurosurgical consultation for dog bite at a regional Level 1 pediatric trauma center over a 15-year period...
October 21, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27763856/relevance-of-allergenic-sensitization-to-cynodon-dactylon-and-phragmites-communis-cross-reactivity-with-pooideae-grasses
#20
M A López-Matas, R Moya, V Cardona, A Valero, P Gaig, A Malet, M Viñas, A García-Moral, M Labrador, E Alcoceba, M Ibero, J Carnés
BACKGROUND AND OBJECTIVES: The homologous group of sweet grasses belongs to the Pooideae subfamily, but grass pollen species from other subfamilies can also cause allergy, such as Cynodon dactylon (Chloridoideae) and Phragmites communis (Arundinoideae). C dactylon and P communis have not been included in the sweet grasses homologous group because of their low cross-reactivity with other grasses. The aims of this study were to investigate the profile of sensitization to C dactylon and P communis in patients sensitized to grasses and to analyze cross-reactivity between these 2 species and temperate grasses...
2016: Journal of Investigational Allergology & Clinical Immunology
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