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https://www.readbyqxmd.com/read/28806971/factors-contributing-to-the-variability-of-a-predictive-score-for-cranial-cruciate-ligament-deficiency-in-labrador-retrievers
#1
Devin P Cunningham, Ayman A Mostafa, Wanda J Gordan-Evans, Randy J Boudrieau, Dominique J Griffon
BACKGROUND: We recently reported that a conformation score derived from the tibial plateau angle (TPA) and the femoral anteversion angle (FAA), best discriminates limbs predisposed to, or affected by cranial cruciate ligament disease (CCLD), from those that are at low risk for CCLD. The specificity and sensitivity of this score were high enough to support further investigations toward its use for large-scale screening of dogs by veterinarians. The next step, which is the objective of the current study, is to determine inter-observer variability of that CCLD score in a large population of Labrador Retrievers...
August 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28806925/genomic-data-illuminates-demography-genetic-structure-and-selection-of-a-popular-dog-breed
#2
Pamela Wiener, Enrique Sánchez-Molano, Dylan N Clements, John A Woolliams, Marie J Haskell, Sarah C Blott
BACKGROUND: Genomic methods have proved to be important tools in the analysis of genetic diversity across the range of species and can be used to reveal processes underlying both short- and long-term evolutionary change. This study applied genomic methods to investigate population structure and inbreeding in a common UK dog breed, the Labrador Retriever. RESULTS: We found substantial within-breed genetic differentiation, which was associated with the role of the dog (i...
August 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28804710/application-of-survival-analysis-and-multistate-modeling-to-understand-animal-behavior-examples-from-guide-dogs
#3
Lucy Asher, Naomi D Harvey, Martin Green, Gary C W England
Epidemiology is the study of patterns of health-related states or events in populations. Statistical models developed for epidemiology could be usefully applied to behavioral states or events. The aim of this study is to present the application of epidemiological statistics to understand animal behavior where discrete outcomes are of interest, using data from guide dogs to illustrate. Specifically, survival analysis and multistate modeling are applied to data on guide dogs comparing dogs that completed training and qualified as a guide dog, to those that were withdrawn from the training program...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28802273/evidence-for-borrelia-bavariensis-infections-of-ixodes-uriae-within-seabird-colonies-of-the-north-atlantic-ocean
#4
Hannah J Munro, Nicholas H Ogden, L Robbin Lindsay, Gregory J Robertson, Hugh Whitney, Andrew S Lang
The first report of members of the spirochete genus Borrelia in the seabird tick, Ixodes uriae, and seabird colonies occurred during the early 1990s. Since then, Borrelia spp. have been detected in these ticks and seabird colonies around the world. To-date, the primary species detected has been B. garinii, with rare occurrences of B. burgdorferi sensu stricto and B. lusitaniae. During our research on Borrelia and I. uriae in seabird colonies of Newfoundland and Labrador, Canada, we have identified B. bavariensis in I...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28798744/the-mast-cell-contact-and-coagulation-system-connection-in-anaphylaxis
#5
REVIEW
Mar Guilarte, Anna Sala-Cunill, Olga Luengo, Moisés Labrador-Horrillo, Victoria Cardona
Anaphylaxis is the most severe form of allergic reaction, resulting from the effect of mediators and chemotactic substances released by activated cells. Mast cells and basophils are considered key players in IgE-mediated human anaphylaxis. Beyond IgE-mediated activation of mast cells/basophils, further mechanisms are involved in the occurrence of anaphylaxis. New insights into the potential relevance of pathways other than mast cell and basophil degranulation have been unraveled, such as the activation of the contact and the coagulation systems...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28782436/charcot-leyden-crystals-do-they-exist-in-veterinary-species-a-case-report-and-literature-review
#6
Eunju Choi, Andrew D Miller, Elizabeth Devenish, Makoto Asakawa, Marina McConkey, Jeanine Peters-Kennedy
The Charcot-Leyden crystal (CLC) is a major human eosinophil protein that readily crystallizes; these crystals are common in eosinophilic diseases. Although anecdotal existence of these crystals is known in veterinary pathology, definitive reports do not exist, to our knowledge. We identified eosinophilic crystals in a laryngeal myxosarcoma from a 2-y-old, spayed female, Labrador Retriever dog that were tentatively interpreted as CLCs. However, Ziehl-Neelsen acid-fast stain was negative, arguing against CLCs...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28776921/retinal-detachment-and-glaucoma-in-the-boston-terrier-and-shih-tzu-following-phacoemulsification-135-patients-2000-2014
#7
Braidee C Foote, Samantha L Pederson, Anja Welihozkiy, Jessica M Stine, Susan M Carastro, Stacy E Andrew, Tammy M Michau
OBJECTIVES: To report the cumulative incidence of retinal detachment (RD) and glaucoma following phacoemulsification in Boston Terriers and Shih Tzu in the southeastern United States over a 14-year period and investigate the potential predisposing risk factors. METHODS: Medical records of 83 Shih Tzu and 52 Boston Terriers that underwent phacoemulsification between 2000 and 2014, with or without intraocular lens placement, were reviewed. For a comparison population, phacoemulsification data from 45 Labrador Retrievers, 73 Schnauzers, and 159 Bichon Frises were evaluated...
August 3, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28765616/vitamin-d-receptor-and-calcium-sensing-receptor-polymorphisms-and-colorectal-cancer-survival-in-the-newfoundland-population
#8
Yun Zhu, Peizhong Peter Wang, Guangju Zhai, Bharati Bapat, Sevtap Savas, Jennifer R Woodrow, Ishor Sharma, Yuming Li, Xin Zhou, Ning Yang, Peter T Campbell, Elizabeth Dicks, Patrick S Parfrey, John R Mclaughlin
BACKGROUND: Increased serum levels of vitamin D and calcium have been associated with lower risks of colorectal cancer (CRC) incidence and mortality. These inverse associations may be mediated by the vitamin D receptor (VDR) and the calcium-sensing receptor (CASR). We investigated genetic variants in VDR and CASR for their relevance to CRC prognosis. METHODS: A population-based cohort of 531 CRC patients diagnosed from 1999 to 2003 in Newfoundland and Labrador, Canada, was followed for mortality and cancer recurrence until April 2010...
August 1, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28758273/assessment-of-computed-tomography-derived-cricoid-cartilage-and-tracheal-dimensions-to-evaluate-degree-of-cricoid-narrowing-in-brachycephalic-dogs
#9
Lynda Rutherford, Lee Beever, Mieghan Bruce, Gert Ter Haar
The aims of this observational, analytical, retrospective study were to (i) obtain computed tomographic (CT) cricoid dimensions (height, width, and transverse-sectional area), (ii) compare the cricoid dimensions between brachycephalic and mesaticephalic breeds, and (iii) compare cricoid cartilage dimensions between dogs without and affected with brachycephalic airway syndrome. The study is important to help to further evaluate and understand the anatomical components of brachycephalic airway syndrome. Measurements were performed in 147 brachycephalic and 59 mesaticephalic dogs...
July 30, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28756720/exploration-of-mtdna-control-region-sequences-in-chinese-tibetan-mastiffs
#10
Yin-Xia Li, Yi-Long Gao, Xing-Liang He, Shao-Xian Cao
The control region of mitochondrial DNA (mtDNA) was obtained from 40 purebred Chinese Tibetan Mastiffs (TMs). Sequence structure and genetic diversity were analyzed, and a phylogenetic tree was constructed. The TM mtDNA control region was composed of ETAS (extended termination associated sequences), CD (a central domain) and CSBs (conserved sequenced blocks) and sequence length showed some diversity, which was mainly caused by the number of 10 nucleotide repeat units [5'-GTA CAC GT (G/A) C-3'] between CSB I and CSB II, which ranged from 27 to 35 among individuals...
July 29, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28755272/polymorphism-and-methylation-of-the-mc4r-gene-in-obese-and-non-obese-dogs
#11
Monika Mankowska, Joanna Nowacka-Woszuk, Aneta Graczyk, Paulina Ciazynska, Monika Stachowiak, Marek Switonski
The dog is considered to be a useful biomedical model for human diseases and disorders, including obesity. One of the numerous genes associated with human polygenic obesity is MC4R, encoding the melanocortin 4 receptor. The aim of our study was to analyze polymorphisms and methylation of the canine MC4R in relation to adiposity. Altogether 270 dogs representing four breeds predisposed to obesity: Labrador Retriever (n = 187), Golden Retriever (n = 38), Beagle (n = 28) and Cocker Spaniel (n = 17), were studied...
July 28, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28754976/constraining-shifts-in-north-atlantic-plate-motions-during-the-palaeocene-by-u-pb-dating-of-svalbard-tephra-layers
#12
Morgan T Jones, Lars E Augland, Grace E Shephard, Seth D Burgess, Gauti T Eliassen, Malte M Jochmann, Bjarki Friis, Dougal A Jerram, Sverre Planke, Henrik H Svensen
Radioisotopic dating of volcanic minerals is a powerful method for establishing absolute time constraints in sedimentary basins, which improves our understanding of the chronostratigraphy and evolution of basin processes. The relative plate motions of Greenland, North America, and Eurasia changed several times during the Palaeogene. However, the timing of a key part of this sequence, namely the initiation of compression between Greenland and Svalbard, is currently poorly constrained. The formation of the Central Basin in Spitsbergen is inherently linked to changes in regional plate motions, so an improved chronostratigraphy of the sedimentary sequence is warranted...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28750790/evaluation-of-the-effect-of-mesotherapy-in-the-management-of-osteoarthritis-related-pain-in-a-police-working-dog-using-the-canine-brief-pain-inventory
#13
REVIEW
João Carlos Alves, Ana Margarida Santos
CASE DESCRIPTON: A 9-year-old, 33.4kg (73.63Lb) male entire drug detection Labrador Retriever Dog was presented with an history of constant lameness from the right thoracic limb, aggravated with exercise and work. CLINICAL FIDINGS: Clinical examination revealed mild signs of pain on the manipulation of the elbow joint, with reduced range of motion on the end feel of joint flexion and extension and crepitation. Radiographic examination of the right elbow joint revealed severe, chronic osteoarthritis, with osteophyte formation on the humeral epicondyles and articular margin of the distomedial humerus, with a narrowed joint space, and osteophytes on the proximal radius, proximomedial ulna, and anconeal process...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28750785/cerebellar-cortical-abiotrophy-in-young-labrador-retrievers
#14
Chandreyee Sen, Ashwani Kumar Sharma, Charanjit Singh Randhawa, Kuldip Gupta
Cerebellar abiotrophy is a hereditary degenerative disorder of the central nervous system in humans and animals. Four male and one female Labrador-retriever pups were presented with clinical signs of head swaying with intention tremor, loss of target oriented movement, wide base stance, forelimb hypermetria, and hindlimb ataxia leading to falling off during ambulation. On histopathologic examination of cerebellum, cerebellar cortical abiotrophy was confirmed with extensive loss of Purkinje cells, diminution of granular layer, relative thickening and foliar gliosis in white matter...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28739597/a-large-deletion-in-the-nsdhl-gene-in-labrador-retrievers-with-a-congenital-cornification-disorder
#15
Anina Bauer, Michela De Lucia, Vidhya Jagannathan, Giorgia Mezzalira, Margaret L Casal, Monika M Welle, Tosso Leeb
In heterozygous females affected by an X-linked skin disorder, lesions often appear in a characteristic pattern, the so-called Blaschko's lines. We investigated a female Labrador Retriever and her crossbred daughter, which both showed similar clinical lesions that followed Blaschko's lines. The two male littermates of the affected daughter had died at birth suggesting a monogenic X-chromosomal semi-dominant mode of inheritance. Whole genome sequencing of the affected daughter and subsequent automated variant filtering with respect to 188 non-affected control dogs of different breeds revealed 332 heterozygous variants on the X-chromosome private to the affected dog...
July 24, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28726244/computed-tomographic-morphometry-of-tympanic-bulla-shape-and-position-in-brachycephalic-and-mesaticephalic-dog-breeds
#16
Ben Mielke, Richard Lam, Gert Ter Haar
Anatomic variations in skull morphology have been previously described for brachycephalic dogs; however there is little published information on interbreed variations in tympanic bulla morphology. This retrospective observational study aimed to (1) provide detailed descriptions of the computed tomographic (CT) morphology of tympanic bullae in a sample of dogs representing four brachycephalic breeds (Pugs, French Bulldogs, English Bulldog, and Cavalier King Charles Spaniels) versus two mesaticephalic breeds (Labrador retrievers and Jack Russell Terriers); and (2) test associations between tympanic bulla morphology and presence of middle ear effusion...
July 20, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28724487/effect-of-wearing-a-telemetry-jacket-on-behavioral-and-physiologic-parameters-of-dogs-in-the-open-field-test
#17
Richard E Fish, Melanie L Foster, Margaret E Gruen, Barbara L Sherman, Davidc C Dorman
Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologic measurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and other parameters has not been evaluated. This pilot study assessed the effect of a telemetry vest on behavioral and physiologic responses to an environmental stressor, the sounds of a thunderstorm, in Labrador retrievers. Dogs were assigned to one of 2 experimental groups (Vest and No-Vest, n = 8 dogs per group) by using a matched pairs design, with a previously determined, sound-associated anxiety score as the blocking variable...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28708517/factors-affecting-the-reproductive-performance-of-bitches-a-prospective-cohort-study-involving-1203-inseminations-with-fresh-and-frozen-semen
#18
F K Hollinshead, D W Hanlon
The aim of this prospective cohort study was to utilize multivariable statistical methods to identify factors that significantly affected whelping rate, litter size and gestation length in a large population of bitches of many different breeds, presented for routine breeding management. In addition, we aimed to determine the incidence of dystocia and the proportion of bitches undergoing a caesarean section procedure. A total of 1146 individual bitches representing 84 different breeds contributed 1203 inseminations over the 9 year (2007-2015) study period...
June 22, 2017: Theriogenology
https://www.readbyqxmd.com/read/28706527/localization-of-sphingolipid-enriched-plasma-membrane-regions-and-long-chain-base-composition-during-mature-fruit-abscission-in-olive
#19
Maria C Parra-Lobato, Miguel A Paredes, Juana Labrador, Mariana Saucedo-García, Marina Gavilanes-Ruiz, Maria C Gomez-Jimenez
Sphingolipids, found in membranes of eukaryotic cells, have been demonstrated to carry out functions in various processes in plant cells. However, the roles of these lipids in fruit abscission remain to be determined in plants. Biochemical and fluorescence microscopy imaging approach has been adopted to investigate the accumulation and distribution of sphingolipids during mature-fruit abscission in olive (Olea europaea L. cv. Picual). Here, a lipid-content analysis in live protoplasts of the olive abscission zone (AZ) was made with fluorescent dyes and lipid analogs, particularly plasma membrane sphingolipid-enriched domains, and their dynamics were investigated in relation to the timing of mature-fruit abscission...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28702908/water-quality-and-health-in-northern-canada-stored-drinking-water-and-acute-gastrointestinal-illness-in-labrador-inuit
#20
Carlee J Wright, Jan M Sargeant, Victoria L Edge, James D Ford, Khosrow Farahbakhsh, Inez Shiwak, Charlie Flowers, Sherilee L Harper
One of the highest self-reported incidence rates of acute gastrointestinal illness (AGI) in the global peer-reviewed literature occurs in Inuit communities in the Canadian Arctic. This high incidence of illness could be due, in part, to the consumption of contaminated water, as many northern communities face challenges related to the quality of municipal drinking water. Furthermore, many Inuit store drinking water in containers in the home, which could increase the risk of contamination between source and point-of-use (i...
July 12, 2017: Environmental Science and Pollution Research International
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