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https://www.readbyqxmd.com/read/28432368/indoor-radon-in-micro-geological-setting-of-an-indigenous-community-in-canada-a-pilot-study-for-hazard-identification
#1
Atanu Sarkar, Derek Hc Wilton, Erica Fitzgerald
BACKGROUND: Radon is the second leading cause of lung cancer after smoking. In Canada, the health authorities have no access to comprehensive profile of the communities built over uranium-rich micro-geological settings. The present indoor radon monitoring guideline is unable to provide an accurate identification of health hazards due to discounting several parameters of housing characteristics. OBJECTIVE: To explore indoor radon levels in a micro-geological setting known for high uranium in bedrock and to develop a theoretical model for a revised radon testing protocol...
April 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28418804/determinants-of-nonmedically-indicated-in-hospital-supplementation-of-infants-whose-birthing-parents-intended-to-exclusively-breastfeed
#2
Julia Temple Newhook, Leigh Anne Newhook, William K Midodzi, Janet Murphy Goodridge, Lorraine Burrage, Nicole Gill, Beth Halfyard, Laurie Twells
BACKGROUND: Despite high rates of intention to exclusively breastfeed, rates of exclusive breastfeeding in Canada are low. Supplementation may begin in hospital and is associated with reduced breastfeeding duration. Research aim: The aim of this investigation was to explore determinants of in-hospital nonmedically indicated supplementation of infants whose birthing parents intended to exclusively breastfeed. METHODS: This study is a cross-sectional one-group nonexperimental design, focused on participants who intended to exclusively breastfeed for 6 months ( n = 496)...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28396505/genetic-characterisation-of-dog-personality-traits
#3
Joanna Ilska, Marie J Haskell, Sarah C Blott, Enrique Sánchez-Molano, Zita Polgar, Sarah E Lofgren, Dylan N Clements, Pam Wiener
The genetic architecture of behavioural traits in dogs is of great interest to owners, breeders and professionals involved in animal welfare, as well as to scientists studying the genetics of animal (including human) behaviour. The genetic component of dog behaviour is supported by between-breed differences and some evidence of within-breed variation. However, it is a challenge to gather sufficiently large datasets to dissect the genetic basis of complex traits such as behaviour, which are both time-consuming and logistically difficult to measure, and known to be influenced by non-genetic factors...
April 10, 2017: Genetics
https://www.readbyqxmd.com/read/28381131/severe-brachycephalic-obstructive-airway-syndrome-is-associated-with-hypercoagulability-in-dogs
#4
Courtney Crane, Elizabeth A Rozanski, Amanda L Abelson, Armelle deLaforcade
We evaluated whether dogs with severe brachycephalic obstructive airway syndrome (BOAS) developed a hypercoagulable state similar to people with obstructive sleep apnea. Five dogs with grade 3 BOAS were included as well as 5 healthy control Labrador Retrievers. Venous blood samples were collected from each dog for performance of thromboelastography and determination of hematocrit and platelet count. Groups were compared using a t-test, with p < 0.05 considered significant. Thromboelastography results identified that all BOAS dogs were hypercoagulable compared to the Labradors, having significantly shortened clotting time with increased angle, maximal amplitude, and clot rigidity...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28379989/genome-wide-association-analysis-in-dogs-implicates-99-loci-as-risk-variants-for-anterior-cruciate-ligament-rupture
#5
Lauren A Baker, Brian Kirkpatrick, Guilherme J M Rosa, Daniel Gianola, Bruno Valente, Julia P Sumner, Wendy Baltzer, Zhengling Hao, Emily E Binversie, Nicola Volstad, Alexander Piazza, Susannah J Sample, Peter Muir
Anterior cruciate ligament (ACL) rupture is a common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rupture of a graft repair is also common. Risk of rupture is increased in females. ACL rupture is also common in dogs. Disease prevalence exceeds 5% in several dog breeds, ~100 fold higher than human beings. We provide insight into the genetic etiology of ACL rupture by genome-wide association study (GWAS) in a high-risk breed using 98 case and 139 control Labrador Retrievers...
2017: PloS One
https://www.readbyqxmd.com/read/28360883/continuous-monitoring-of-essential-tremor-using-a-portable-system-based-on-smartwatch
#6
Xiaochen Zheng, Alba Vieira Campos, Joaquín Ordieres-Meré, Jose Balseiro, Sergio Labrador Marcos, Yolanda Aladro
INTRODUCTION: Essential tremor (ET) shows amplitude fluctuations throughout the day, presenting challenges in both clinical and treatment monitoring. Tremor severity is currently evaluated by validated rating scales, which only provide a timely and subjective assessment during a clinical visit. Motor sensors have shown favorable performances in quantifying tremor objectively. METHODS: A new highly portable system was used to monitor tremor continuously during daily lives...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28344412/clinical-and-hematobiochemical-response-in-canine-monocytic-ehrlichiosis-seropositive-dogs-of-punjab
#7
Manasa R Kottadamane, Pritpal Singh Dhaliwal, Lachhman Das Singla, Baljinder Kumar Bansal, Sanjeev Kumar Uppal
AIM: As in India especially, the Punjab state sero-prevalence and distribution of ehrlichiosis in relation to clinico-hematobiochemical response remains largely unexplored. Thus, this study was designed to determine the prevalence of vector (tick)-borne tropical canine pancytopenia caused by Ehrlichia canis through enzyme labeled ImmunoComb(®) (IC) assay in dogs from in and around Ludhiana, Punjab. Correlation of prevalence was made with various clinico-hematobiochemical parameters. MATERIALS AND METHODS: Seroprevalence study was carried out using IC(®) test kit (Biogal, Galed Labs)...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28336525/extracellular-tdp-43-aggregates-target-mapk-mak-mrk-overlapping-kinase-mok-and-trigger-caspase-3-il-18-signaling-in-microglia
#8
María M Leal-Lasarte, Jaime M Franco, Adahir Labrador-Garrido, David Pozo, Cintia Roodveldt
Dysregulated microglial responses are central in neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar disease (FTLD). Pathologic TDP-43, which is typically found in intracellular inclusions, is a misfolding protein with emerging roles in ALS and FTLD. Recently, TDP-43 species have been found in extracellular fluids of patients; however, the overall implications of TDP-43-mediated signaling linked to neuroinflammation are poorly understood. Our work-the first, to our knowledge, to focus on innate immunity responses to TDP-43 aggregates-shows that such species are internalized by microglia and cause abnormal mobilization of endogenous TDP-43...
March 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28331835/primary-leiomyosarcoma-of-the-jugular-vein-in-a-dog
#9
Alessio Pierini, Filippo Cinti, Diana Binanti, Guido Pisani
A four-year-old, male, Labrador retriever was referred for removal of a spindle cell sarcoma involving the right jugular vein. A post-contrast CT scan showed a seven-centimeter subcutaneous mass originated from the right external jugular vein, which was partially obstructed and showing contrast stasis, suggested a primary intravascular tumor of the jugular vein. The mass was resected, and histological evaluation was consistent with grade II intravenous spindle cell sarcoma of the jugular vein. Immunohistochemical positivity for vimentin, desmin, and αSMA antibody and negativity for S-100 protein confirmed venous leiomyosarcoma...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28326983/morphologic-and-morphometric-description-of-the-temporomandibular-joint-in-the-domestic-dog-using-computed-tomography
#10
Lenin A Villamizar-Martinez, Cristian M Villegas, Marco A Gioso, Alexander M Reiter, Geni C Patricio, Ana C Pinto
The temporomandibular joint (TMJ) in the domestic dog is a synovial joint with 2 articular surfaces, the mandibular fossa of the squamous portion of the temporal bone and the articular head of the condylar process of the mandible. Although different diagnostic imaging techniques have been used to study the TMJ in dogs, morphologic and morphometric studies based on computed tomography (CT) are scarce. The purpose of the present study was to describe the morphologic and morphometric features of the TMJ in domestic dogs using CT...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28316386/successful-therapeutic-management-of-canine-isosporosis-in-puppies
#11
Nishiswapna Garanayak, A R Gupta, R C Patra
Four labrador male puppies were confirmed for the Isospora spp infection by direct smear and flotation method following complains of anorexia, haematemesis and haematochezia. The puppies were treated with trimethoprime and sulphamethoxazole @ 40 mg/kg body weight in combination with metronidazole @ 10 mg/kg body weight twice daily for 5 days which was supported with fluid therapy, aniemetics and plasma expanders. All the animals showed completed clinical recovery along with clearing of faecal oocyst.
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28296236/development-of-the-endocrine-pancreas-in-the-beagle-dog-from-fetal-to-adult-life
#12
Emilie Bricout-Neveu, Severine Pechberty, Karine Reynaud, Cindy Maenhoudt, Marie José Lecomte, Philippe Ravassard, Paul Czernichow
Our objectives were to describe, in Beagle dogs, the ontogenesis of beta (insulin-producing) and alpha (glucagon-producing) cells from fetal to early postnatal life and adulthood. In addition, to have some insight into interspecies comparison, Beagle dog pancreases were compared to pancreases from a Labrador and Chow Chow. At midgestation, the epithelium was dense, beta cells scarce, and alpha cells numerous and concentrated in the center of the pancreatic bud. From 36 to 45 days post conception (pc), beta cell numbers increased and the epithelium expanded and branched out...
March 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28284232/engaging-patients-in-health-research-identifying-research-priorities-through-community-town-halls
#13
Holly Etchegary, Lisa Bishop, Catherine Street, Kris Aubrey-Bassler, Dale Humphries, Lidewij Eva Vat, Brendan Barrett
BACKGROUND: The vision of Canada's Strategy for Patient-Oriented Research is that patients be actively engaged as partners in health research. Support units have been created across Canada to build capacity in patient-oriented research and facilitate its conduct. This study aimed to explore patients' health research priorities in the province of Newfoundland and Labrador (NL). METHODS: Eight town halls were held with members of the general public in rural and urban settings across the province...
March 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28283074/vertical-force-distribution-in-the-paws-of-sound-labrador-retrievers-during-walking
#14
N Schwarz, A Tichy, C Peham, B Bockstahler
In contrast to gait analysis in humans, where pedobarography is an integral part of biomechanical studies, veterinary researchers have rarely investigated vertical force distribution (VFD) in the paws of dogs. The aim of this study was to investigate the VFD of peak of vertical force (PFz), vertical impulse (IFz) and time of occurrence of PFz during stance phase (TPFz) in 20 sound, adult Labrador retrievers walking normally on a pressure plate. A technique was used that divided the canine paw prints into quadrants...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28275785/-histological-evaluations-on-periapical-tissues-after-irradiation-by-erbium-doped-yttrium-aluminum-garnet-laser-in-labradors-dogs
#15
Hao-Ming Wang, Meng-Qi Zhou, Jin Hong
PURPOSE: To investigate the thermal effects on periapical tissues of Labrador dogs after intra-canal irradiation by erbium-doped yttrium aluminum garnet (Er:YAG) laser at different powers based on the antibacterial experiment of Enterococcus faecalis and Escherichia coli in root canals with an isthmus, to assess the histological changes, and to prove the safety for clinical applications. METHODS: Two hundred root canals of 10 healthy adult Labradors dogs were selected and divided into 5 groups...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28273034/evaluating-compression-or-expansion-of-morbidity-in-canada-trends-in-life-expectancy-and-health-adjusted-life-expectancy-from-1994-to-2010
#16
Colin Steensma, Lidia Loukine, Bernard C Choi
INTRODUCTION: The objective of this study was to investigate whether morbidity in Canada, at the national and provincial levels, is compressing or expanding by tracking trends in life expectancy (LE) and health-adjusted life expectancy (HALE) from 1994 to 2010. "Compression" refers to a decrease in the proportion of life spent in an unhealthy state over time. It happens when HALE increases faster than LE. "Expansion" refers to an increase in the proportion of life spent in an unhealthy state that happens when HALE is stable or increases more slowly than LE...
March 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28270398/pulmonary-vein-mass-with-extension-to-the-left-atrium-diagnosed-by-echocardiography
#17
Jezreel Labrador Taquiso, Jaime Alfonso Manalo Aherrera, Jose Donato Magno, Eric Oliver Sison
We report a case of a man aged 65 years presenting with chronic cough, haemoptysis and intermittent atrial tachyarrhythmias on ECG. On 2D transthoracic echocardiography, an incidental left atrial mass was seen, initially thought to be a thrombus predisposed by intermittent atrial fibrillation. Transoesophageal echocardiography confirmed that this left atrial mass originated from a fixed, non-homogenous, right superior pulmonary vein mass with an extracardiac extension. Because of this finding, a thorough search for a primary focus lead to the discovery of a contiguous posterior mediastinal mass, which was a round cell neoplasm on histology...
March 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28263119/surgical-management-of-pivot-shift-phenomenon-in-a-dog
#18
Rebekah C Knight, David G Thomson, Alan Danielski
CASE DESCRIPTION A 6.8-year-old neutered male Labrador Retriever-Poodle mix was evaluated because of continued left pelvic limb lameness unresponsive to conservative management 1 year after undergoing tibial plateau leveling osteotomy (TPLO). CLINICAL FINDINGS A jerking lateral movement of the left stifle joint was detected during walking. Orthopedic examination revealed a pivot-shift phenomenon (PSP). Palpation elicited no signs of discomfort over the TPLO plate or caudomedial aspect of the stifle joint. Radiography revealed complete bone fusion at the osteotomy site and only mild joint effusion...
March 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28248800/mixed-connective-tissue-disease-and-epitope-spreading-an-historical-cohort-study
#19
Laura Escolà-Vergé, Iago Pinal-Fernandez, Andreu Fernandez-Codina, Eduardo L Callejas-Moraga, Juan Espinosa, Ana Marin, Moises Labrador-Horrillo, Albert Selva-O'Callaghan
OBJECTIVES: Mixed connective tissue disease (MCTD) is characterized by the presence of anti-U1-snRNP autoantibodies and a variable set of associated clinical features. Some MCTD patients test positive over time to autoantibodies against Sm, proteins spatially related with U1-snRNP. This situation has been attributed to expanding of the autoimmune response by a phenomenon known as epitope spreading. Our aim was to study the frequency of this phenomenon in MCTD patients and the specific clinical features of those with epitope spreading...
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28239862/primary-ureteral-leiomyosarcoma-in-a-dog
#20
F W Yap, X B Huizing, R Rasotto, K L Bowlt-Blacklock
CASE DESCRIPTION: A nearly 6-year-old female spayed Labrador Retriever was presented for acute abdominal pain and lethargy. The dog had no previous health concerns apart from occasional episodes of urinary incontinence in the 2 months prior to presentation. A retroperitoneal mass involving the right ureter was found during the investigations. Serum urea was mildly elevated, but the serum creatinine was within the normal range. No distant metastases were detected. A right ureteronephrectomy was performed...
March 2017: Australian Veterinary Journal
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