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https://www.readbyqxmd.com/read/28933602/lactoferrin-structure-function-denaturation-and-digestion
#1
Bo Wang, Yakindra Prasad Timilsena, Ewan Blanch, Benu Adhikari
Lactoferrin (LF) is a multifunctional protein occurring in many biological secretions including milk. It possesses iron binding/transferring, antibacterial, antiviral, antifungal, anti-inflammatory and anti-carcinogenic properties. These functional properties intimately depend on the structural integrity of LF especially its higher order conformation. LF is primarily extracted from bovine milk and it is subsequently added into many commercial products such as nutritional supplements, infant formula, cosmetics and toothpaste...
September 21, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28933306/diet-bioactive-compounds-implications-for-oxidative-stress-and-inflammation-in-the-vascular-system
#2
Morena Gabriele, Laura Pucci
BACKGROUND AND OBJECTIVE: Increasing evidence has demonstrated that dietary products and their active components are independently or jointly responsible for the apparent reduction of the cardiovascular diseases (CVDs) risk. DISCUSSION: Nowadays, there is a growing attention in the use of nutraceuticals as a new approach for the prevention and management of many diseases, as well as for controlling rising of chronic illnesses with minimal side effects. Food-derived peptides, as well as peptide-rich protein hydrolysates, represent new and valuable tools for the prevention of metabolic and cardiovascular diseases, acting as modulators of oxidative stress, inflammation, and overactivity of the renin-angiotensin system (RAS)...
September 21, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28932870/ablation-of-kallikrein-7-klk7-in-adipose-tissue-ameliorates-metabolic-consequences-of-high%C3%A2-fat-diet-induced-obesity-by-counteracting-adipose-tissue-inflammation-in-vivo
#3
Konstanze Zieger, Juliane Weiner, Anne Kunath, Martin Gericke, Kerstin Krause, Matthias Kern, Michael Stumvoll, Nora Klöting, Matthias Blüher, John T Heiker
Vaspin is an adipokine which improves glucose metabolism and insulin sensitivity in obesity. Kallikrein 7 (KLK7) is the first known protease target inhibited by vaspin and a potential target for the treatment of metabolic disorders. Here, we tested the hypothesis that inhibition of KLK7 in adipose tissue may beneficially affect glucose metabolism and adipose tissue function. Therefore, we have inactivated the Klk7 gene in adipose tissue using conditional gene-targeting strategies in mice. Klk7-deficient mice (ATKlk7 (-/-)) exhibited less weight gain, predominant expansion of subcutaneous adipose tissue and improved whole body insulin sensitivity under a high fat diet (HFD)...
September 20, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28930147/profiling-of-polyphenol-composition-and-antiradical-capacity-of-erica-cinerea
#4
Alfredo Aires, Rosa Carvalho
The aim of the current study was to determine the profile and content of polyphenols present in Erica cinerea, an important plant species from Northern Portuguese flora and often reported as having anti-inflammatory, antioxidant, and anti-radical activity. The analysis of polyphenols was performed by HPLC-DAD/UV-Vis, and the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) method was used to evaluate its radical scavenging activity. HPLC analysis showed that both plants presented a great diversity of compounds, with 33% flavones, 28% flavanols, and 26% hydroxycinnamic acids...
September 20, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28919787/computational-tool-for-optimizing-the-essential-oils-utilization-in-inhibiting-the-bacterial-growth
#5
Noha E El-Attar, Wael A Awad
Day after day, the importance of relying on nature in many fields such as food, medical, pharmaceutical industries, and others is increasing. Essential oils (EOs) are considered as one of the most significant natural products for use as antimicrobials, antioxidants, antitumorals, and anti-inflammatories. Optimizing the usage of EOs is a big challenge faced by the scientific researchers because of the complexity of chemical composition of every EO, in addition to the difficulties to determine the best in inhibiting the bacterial activity...
2017: Advances and Applications in Bioinformatics and Chemistry: AABC
https://www.readbyqxmd.com/read/28918663/biosynthesis-of-gold-and-silver-chloride-nanoparticles-mediated-by-crataegus-pinnatifida-fruit-extract-in-vitro-study-of-anti-inflammatory-activities
#6
Jong Pyo Kang, Yeon Ju Kim, Priyanka Singh, Yue Huo, Veronika Soshnikova, Josua Markus, Sungeun Ahn, Mohan Chokkalingam, Hyun A Lee, Deok Chun Yang
This research article investigates the one-pot synthesis of gold and silver chloride nanoparticles functionalized by fruit extract of Crataegus pinnatifida as reducing and stabilizing agents and their possible roles as novel anti-inflammatory agents. Hawthorn (C. pinnatifida) fruits are increasingly popular as raw materials for functional foods and anti-inflammatory potential agents because of abundant flavonoids. The reduction of auric chloride and silver nitrate by the aqueous fruit extract led to the formation of gold and silver chloride nanoparticles...
September 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28916855/green-approach-for-synthesis-of-zinc-oxide-nanoparticles-from-andrographis-paniculata-leaf-extract-and-evaluation-of-their-antioxidant-anti-diabetic-and-anti-inflammatory-activities
#7
Govindasamy Rajakumar, Muthu Thiruvengadam, Govindarasu Mydhili, Thandapani Gomathi, Ill-Min Chung
Bio-mediated synthesis of zinc oxide nanoparticles (ZnO NPs) was carried out by utilizing the reducing and capping potential of Andrographis paniculata leaf extract. The capped ZnO NPs were characterized using UV-Vis, XRD, FTIR, SEM, TEM and SAED analyses. FTIR analysis suggested the role of phenolic compounds, terpenoids, and proteins of A. paniculata leaf extract, in nucleation and stability of ZnO NPs. XRD pattern compared with the standard confirmed spectrum of zinc oxide particles formed in the present experiments were in the form of nanocrystals, as evidenced by the peaks at 2θ values...
September 15, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28916191/%C3%AE-the-hydro-alcoholic-extracts-of-sardinian-wild-thistles-onopordum-spp-inhibit-tnf%C3%AE-induced-il-8-secretion-and-nf-%C3%AE%C2%BAb-pathway-in-human-gastric-epithelial-ags-cells
#8
Arianna Marengo, Marco Fumagalli, Cinzia Sanna, Andrea Maxia, Stefano Piazza, Cecilia Cagliero, Patrizia Rubiolo, Enrico Sangiovanni, Mario Dell'Agli
ETHNOPHARMACOLOGICAL RELEVANCE: Thistles species (Family: Compositae) are traditionally used in the Mediterranean area, particularly in Sardinia. They are usually gathered from the wild and used for both food and therapeutic purposes, including gastrointestinal disorders. AIM OF THE STUDY: This work aims to evaluate the anti-inflammatory activity of eight wild thistles from Sardinia, in an in vitro model of gastric inflammation, and to identify the major active compounds in the extracts...
September 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28915571/p62-plasmid-can-alleviate-diet-induced-obesity-and-metabolic-dysfunctions
#9
Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B Komissarov, Franco Venanzi, Sergey I Kolesnikov, Albert A Sufianov, Michael Y Sherman, Vladimir L Gabai, Alexander M Shneider
A high-calorie diet (HCD) induces two mutually exacerbating effects contributing to diet-induced obesity (DIO): impaired glucose metabolism and increased food consumption. A link between the metabolic and behavioral manifestations is not well understood yet. We hypothesized that chronic inflammation induced by HCD plays a key role in linking together the two components of diet-induced pathology. Based on this hypothesis, we tested if a plasmid (DNA vaccine) encoding p62 (SQSTM1) would alleviate DIO including its metabolic and/or food consumption abnormalities...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913359/nutraceutical-anti-inflammatory-and-immune-modulatory-effects-of-%C3%AE-glucan-isolated-from-yeast
#10
Umar Bacha, Muhammad Nasir, Sanaullah Iqbal, Aftab Ahmad Anjum
β-Glucan is a dietary fibre, found in many natural sources, and controls chronic metabolic diseases effectively. However, β-glucan from the yeast has rarely been investigated. Objectively, conditions were optimized to isolate β-glucan from the yeast (max. 66% yield); those optimized conditions included 1.0 M NaOH, pH 7.0, and 90°C. The purity and identity of the isolated β-glucan were characterized through FT-IR, SEM, DSC, and physicofunctional properties. The obtained results from DSC revealed highly stable β-glucan (m...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28911610/myrciaria-cauliflora-extract-improves-diabetic-nephropathy-via-suppression-of-oxidative-stress-and-inflammation-in-streptozotocin-nicotinamide-mice
#11
Jeng-Dong Hsu, Chia-Chun Wu, Chi-Nan Hung, Chau-Jong Wang, Hui-Pei Huang
Myrciaria cauliflora is a functional food rich in anthocyanins, possessing antioxidative and anti-inflammatory properties. Our previous results demonstrated M. cauliflora extract (MCE) had beneficial effects in diabetic nephropathy (DN) and via the inhibition of Ras/PI3K/Akt and kidney fibrosis-related proteins. The purpose of this study was to assess the benefit of MCE in diabetes associated with kidney inflammation and glycemic regulation in streptozotocin-nicotinamide (STZ/NA)-induced diabetic mice. Compared with the untreated diabetic group, MCE significantly improved blood glucose and serum biochemical characteristic levels...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911547/multifunctions-of-dietary-polyphenols-in-the-regulation-of-intestinal-inflammation
#12
REVIEW
Makoto Shimizu
Food for specified health use is a type of functional food approved by the Japanese government, with more than 1250 products in 10 health-claim categories being approved as of April 2016. Polyphenols are currently used as functional ingredients in seven of the 10 categories. Although they have not yet been used for the food-for-specified-health-use category of "gut health promotion," polyphenols are expected to contribute to the future development of gut-modulating food. Intestinal functions include digestion/absorption, acting as a barrier, recognition of external factors, and signal transduction...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906554/changes-in-phytochemical-composition-bioactivity-and-in-vitro-digestibility-of-guayusa-leaves-ilex-guayusa-loes-in-different-ripening-stages
#13
José Villacís-Chiriboga, Almudena García-Ruiz, Nieves Baenas, Diego A Moreno, Antonio J Meléndez-Martínez, Carla M Stinco, Lourdes Jerves-Andrade, Fabián León-Tamariz, Johanna Ortiz-Ulloa, Jenny Ruales
BACKGROUND: Guayusa (Ilex guayusa Loes.) leaves, native of the Ecuadorian amazon, are popularly used for preparing teas. This study aimed to assess the influence of leaf age on the phenolic compounds and carotenoids, and the bioactivity and digestibility (in vitro) of aqueous and hydroalcoholic leaf extracts. RESULTS: In total, 14 phenolic compounds were identified and quantified. Chlorogenic acid and quercetin-3-O-hexose were the main representatives of the hydroxycinnamic acids and flavonols, respectively...
September 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28901261/spices-with-breast-cancer-chemopreventive-and-therapeutic-potentials-a-functional-foods-based-review
#14
Aliyu Muhammad, Mohammed Auwal Ibrahim, Ochuko Lucky Erukainure, Ibrahim Malami, Auwal Adamu
Cancer is a disease that affects a significant number of both rural and urban dwellers. Among the various types of cancer, breast cancer is one of the most common diagnosed cancers among females. Its menace can be curbed with locally consumed spices due to their multiple bioactive phytochemicals. This review focuses on the breast cancer chemopreventive and therapeutic potentials of locally consumed spices. The most commonly consumed spices with breast cancer chemopreventive and chemotherapeutic phytochemical include pepper, onions, ginger, garlic, curry and thyme containing many biologically active metabolites ranging from vitamins, fatty acids esters, polyphenols/phenolics, sulfur-containing compounds and anthraquinones with proven antioxidant, anti-inflammatory, immuno-modulatory, antitumor and anticancer properties against breast cancer/carcinogenesis...
September 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28898883/anti-inflammatory-nutrition-and-successful-ageing-in-elderly-individuals-the-multinational-medis-study
#15
Stefanos Tyrovolas, Josep Maria Haro, Alexandra Foscolou, Dimitra Tyrovola, Anargiros Mariolis, Vassiliki Bountziouka, Suzanne Piscopo, Giuseppe Valacchi, Foteini Anastasiou, Efthimios Gotsis, George Metallinos, Natassa Papairakleous, Evangelos Polychronopoulos, Antonia-Leda Matalas, Christos Lionis, Akis Zeimbekis, Josep-Antoni Tur, Labros S Sidossis, Demosthenes B Panagiotakos
BACKGROUND: The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study. METHODS: During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study...
September 9, 2017: Gerontology
https://www.readbyqxmd.com/read/28895370/eosinophilic-esophagitis-current-evidence-based-diagnosis-and-treatment-in-children-and-adults
#16
Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a disease caused by an immune response to food antigens in contact with the esophageal mucosa that has arisen as a common disorder in current clinical practice. Its diagnosis is defined by the combination of symptoms of esophageal dysfunction and inflammation of the esophageal mucosa predominantly by eosinophils. Its chronic course and frequent progression to subepithelial fibrosis leading to strictures and narrow-caliber esophagus indicate the need for treatment. Information provided by recent clinical trials and systematic reviews allowed for the development of new clinical guidelines, endorsed by several European scientific societies...
September 11, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28891983/protective-effects-of-ethanolic-extracts-from-artichoke-an-edible-herbal-medicine-against-acute-alcohol-induced-liver-injury-in-mice
#17
Xuchong Tang, Ruofan Wei, Aihua Deng, Tingping Lei
Oxidative stress and inflammation are well-documented pathological factors in alcoholic liver disease (ALD). Artichoke (Cynara scolymus L.) is a healthy food and folk medicine with anti-oxidative and anti-inflammatory properties. This study aimed to evaluate the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice. Male Institute of Cancer Research mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily...
September 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28891576/in-vitro-assessment-of-the-ability-of-probiotics-blueberry-and-food-carbohydrates-to-prevent-s-pyogenes-adhesion-on-pharyngeal-epithelium-and-modulate-immune-responses
#18
Valentina Taverniti, Alessandro Dalla Via, Mario Minuzzo, Cristian Del Bo', Patrizia Riso, Hanne Frøkiær, Simone Guglielmetti
Group A streptococci (GAS) cause 20-30% of pediatric pharyngitis episodes, which are a major cause of ambulatory care visits. Therefore, a strategy to prevent GAS dissemination in children could significantly benefit public healthcare. Contextually, we assessed the possibility of employing alternative food-grade strategies to be used with the oral probiotic L. helveticus MIMLh5 for the prevention of pharyngeal infections. First, we demonstrated through an antagonism-by-exclusion assay that guaran may potentially prevent S...
September 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28888463/brazil-nuts-nutritional-composition-health-benefits-and-safety-aspects
#19
REVIEW
Bárbara R Cardoso, Graziela B Silva Duarte, Bruna Z Reis, Silvia M F Cozzolino
Brazil nuts are among the richest selenium food sources, and studies have considered this Amazonian nut as an alternative for selenium supplementation. Besides selenium, Brazil nuts present relevant content of other micronutrients such as magnesium, copper, and zinc. The nutritional composition of nuts, also characterized by adequate fatty acid profile and high content of protein and bioactive compounds, has many health benefits. In the present review, we examine the nutritional composition of Brazil nuts, comparing it with other nuts, and describe the relevance of possible contaminants and metal toxicants observed in this nut for human health...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28885710/isoflavones-from-green-vegetable-soya-beans-and-their-antimicrobial-and-antioxidant-activities
#20
Taoyun Wang, Yanli Liu, Xiaoran Li, Qiongming Xu, Yulin Feng, Shilin Yang
BACKGROUND: Green vegetable soya beans, known as Maodou in China, supplied as vegetable-type fruits of soybean plant. Previous study indicated Green vegetable soya beans exhibited anti-oxidative and anti-inflammatory activities. However, the material basis and pharmacological activities of green soybean plant were not unraveled clearly. In this study, we investigated the chemical ingredients and their pharmacological activities. RESULTS: The chemical ingredients investigation indicated that two new isoflavones, 2'-hydroxyerythrin A (1), and daidzein-7-O-β-D-{6''-[(E)-but-2-enoyl]}glycoside (2), together with seven known ones, 7,4'-dihydroxy-6-methoxyisoflavone (3), daidzein (4), daidzin (5), genistein (6), formononetin (7), ononin (8), and isoerythrinin A (9) were obtained...
September 8, 2017: Journal of the Science of Food and Agriculture
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