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https://www.readbyqxmd.com/read/29333888/primary-diffuse-large-b-cell-lymphoma-of-the-ciliary-body
#1
Hayyam Kiratli, Abdullah Ağın, Berrin Büyükeren, Figen Söylemezoğlu
PURPOSE: To report an unusual case of an eye with primary ciliary body lymphoma which came to enucleation allowing detailed histopathological examination. METHODS: A 50-year-old man presented with a painful loss of vision in the left eye. The clinical, imaging, and immunohistopathological features of this case were reviewed. RESULTS: The vision in the left eye was light perception. There were keratic precipitates, an irregular and thickened iris with neovascularization...
January 15, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29332062/cytologic-features-of-malignant-melanoma-with-osteoclast-like-giant-cells
#2
José A Jiménez-Heffernan, Magdalena Adrados, Patricia Muñoz-Hernández, Paloma Fernández-Rico, Ana I Ballesteros-García, Javier Fraga
BACKGROUND: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. CASE: A 57-year-old woman presented with an inguinal lymphadenopathy. Sixteen years before, cutaneous malignant melanoma of the lower limb had been excised...
January 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29330915/effects-of-seed-mixture-sowing-with-resistant-and-susceptible-rice-on-population-dynamics-of-target-planthoppers-and-non-target-stemborers-and-leaffolders
#3
Zhuo Li, Gui-Jun Wan, Long Wang, Megha N Parajulee, Zi-Hua Zhao, Fa-Jun Chen
BACKGROUND: The widespread planting of insect-resistant crops has caused a dramatic shift in agricultural landscapes, thus raising concerns about the potential impact on both target and non-target pests worldwide. In this study, we examined the potential effects of six seed-mixture ratios of insect-resistant dominance (100%-R100, 95%-S05R95, 90%-S10R90, 80%-S20R80, 60%-S40R60, and 0%-S100) on target and non-target pests in a 2-year field trial in southern China. RESULTS: The occurrence of target pests, Nilaparvata lugens and Sogatella furcifera, decreased with the increased ratio of resistant rice, and the mixture ratios with ≥90% resistant rice significantly increased the pest suppression efficiency, with lowest occurrences of non-target pests, Sesamia inferens, Chilo suppressalis and Cnaphalocrocis medinalis, in S100 and S10R90 seed-mixture ratios...
January 13, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29329729/elevated-neuron-specific-enolase-and-s100-calcium-binding-protein-b-concentrations-in-cerebrospinal-fluid-of-patients-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#4
Baozhu Liu, Zuoshan Xie, Guanghui Liu, Yong Gu, Suyue Pan, Honghao Wang
BACKGROUND: Anti‑N‑methyl‑d‑aspartate receptor (NMDAR) encephalitis is a relatively common autoimmune neurological disease of the central nervous system (CNS). Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are structural proteins of the central nervous system (CNS). In patients with CNS injury accompanied by nervous tissue and cellular damage, these structural proteins are released from cells; their extracellular concentrations, including those in cerebrospinal fluid (CSF) and blood, subsequently increase...
January 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29329129/primary-cutaneous-spindle-cell-squamous-carcinoma-expressing-smooth-muscle-actin-diagnostic-pitfalls
#5
Abdullahi Ahmad, Hye Jin Chung, Jag Bhawan
Alpha smooth muscle actin (SMA) belongs to the actin proteins. It is a known immunohistochemical marker for tumors of mesenchymal origin. There have been reports of expression of SMA in certain epithelial malignancies in the head and neck and genital regions. In this study, the authors report a primary cutaneous spindle cell squamous carcinoma expressing SMA. Both high- and low-molecular-weight keratins and p63 were positive, and S100 protein, SOX10, MART-1/Melan-A, and muscle-specific actin stains were negative...
January 11, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29326339/ninety-year-old-man-with-hypereosinophilia-lymphadenopathies-and-pruritus
#6
José Guilherme Freitas, Ana Jorge, Daniel Rei, Joana Graça
We report a case of a 90-year-old man with hypereosinophilia, lymphadenopathies and skin lesions, namely lichenification and pruritus. An aetiological investigation was performed, and a bone marrow (BM) biopsy and aspirate showed a hypercellular marrow with hypereosinophilia without dysmorphia or abnormal elements, and the BM and inguinal node's immunophenotyping denied any presence of abnormal lymphoid cell population. The inguinal node biopsy revealed a multinodular proliferation of large cells S100 and CD1a+, and a diagnosis of Langerhans cell histiocytosis was made...
January 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29326176/combinatorial-omics-analysis-reveals-perturbed-lysosomal-homeostasis-in-collagen-vii-deficient-keratinocytes
#7
Kerstin Thriene, Björn Andreas Grüning, Olivier Bornert, Anika Erxleben, Juna Leppert, Ioannis Athanasiou, Ekkehard Weber, Dimitra Kiritsi, Alexander Nyström, Thomas Reinheckel, Rolf Backofen, Cristina Has, Leena Bruckner-Tuderman, Joern Dengjel
The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are linked to skin fragility and progressive inflammation-driven fibrosis that facilitates aggressive skin cancer. So far, these changes have been linked to mesenchymal alterations, the epithelial consequences of collagen VII loss remaining under-addressed. As epithelial dysfunction is a principal initiator of fibrosis, we performed a comprehensive transcriptome and proteome profiling of primary human keratinocytes to generate global and detailed images of dysregulated epidermal molecular pathways linked to loss of collagen VII...
January 11, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29324470/fibroma-like-pecoma-a-tuberous-sclerosis-complex-related-lesion
#8
Ana B Larque, Richard L Kradin, Ivan Chebib, G Petur Nielsen, Martin K Selig, Elizabeth A Thiele, Anat Stemmer-Rachamimov, Miriam A Bredella, Pawel Kurzawa, Vikram Deshpande
Perivascular epithelioid cell tumor (PEComa), mesenchymal tumors morphologically characterized by epithelioid cells, coexpress melanocytic and muscle markers. Herein, we describe a heretofore-undescribed tuberous sclerosis complex (TSC)-related neoplasm, morphologically resembling a soft tissue fibroma-like lesion, but showing an immunophenotype resembling PEComa. We identified 3 soft tissue fibroma-like lesions in individuals with TSC. We also evaluated 6 TSC-related periungual fibroma as well as a range of non-TSC fibroma-like lesions (n=19)...
January 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29317947/esophageal-granular-cell-tumor-a-case-and-review-of-the-literature
#9
Emmanuel Ofori, Daryl Ramai, Ying X Lui, Madhavi Reddy
Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. They are most commonly observed in the oral cavity, skin and subcutaneous tissue, breast, and respiratory tract. GCTs rarely affect the gastrointestinal tract. We report a 56-year-old female with a medical history of human immunodeficiency virus, hepatitis C, and cholelithiasis, who presented with abdominal pain...
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29316066/smarcb1-ini1-baf47-deficient-pleural-malignant-mesothelioma-with-rhabdoid-features
#10
Noriko Kimura, Masaru Hasegawa, Kenzo Hiroshima
Malignant mesothelioma (MM) with rhabdoid features is an MM variant. Fifteen cases have been reported previously, all of which were combined with other types of MM. Herein, we report an autopsy case of pleural MM with monomorphic rhabdoid features. The patient was a 62-year-old male without a history of asbestos exposure. An autopsy revealed a soft, granular tumor that replaced the entire left pleura and had invaded to the diaphragm and lower lobe of the lung. The tumor cells, which had eosinophilic plump cytoplasm and eccentric nuclei, were loosely cohesive...
January 5, 2018: Pathology International
https://www.readbyqxmd.com/read/29313282/ertugliflozin-and-sitagliptin-co-initiation-in-patients-with-type-2-diabetes-the-vertis-sita-randomized-study
#11
Sam Miller, Tania Krumins, Haojin Zhou, Susan Huyck, Jeremy Johnson, Gregory Golm, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring
INTRODUCTION: Ertugliflozin is an oral sodium-glucose cotransporter 2 inhibitor that is being developed to treat type 2 diabetes mellitus (T2DM). This study assessed the efficacy and safety of co-initiation of ertugliflozin and sitagliptin compared with placebo in patients with T2DM inadequately controlled on diet and exercise. METHODS: In this phase III, randomized, double-blind, multicenter, placebo-controlled 26-week study (NCT02226003), patients with T2DM and glycated hemoglobin (HbA1c) 8...
January 8, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29309308/novel-ewsr1-smad3-gene-fusions-in-a-group-of-acral-fibroblastic-spindle-cell-neoplasms
#12
Yu-Chien Kao, Lei Zhang, Yun-Shao Sung, Albert J H Suurmeijer, Cristina R Antonescu
Benign/low-grade fibroblastic tumors encompass a broad spectrum of tumors with different morphologies and molecular genetic abnormalities. However, despite significant progress in recent genomic characterization, there are still tumors in this histologic spectrum that are difficult to classify, lacking known molecular characteristics. Triggered by a challenging congenital spindle cell neoplasm arising in the heel of a 1-year-old boy, we applied RNA sequencing for genetic discovery and identified a novel EWSR1-SMAD3 gene fusion...
January 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29309307/a-distinct-malignant-epithelioid-neoplasm-with-gli1-gene-rearrangements-frequent-s100-protein-expression-and-metastatic-potential-expanding-the-spectrum-of-pathologic-entities-with-actb-malat1-ptch1-gli1-fusions
#13
Cristina R Antonescu, Narasimhan P Agaram, Yun-Shao Sung, Lei Zhang, David Swanson, Brendan C Dickson
ACTB-GLI1 fusions have been reported as the pathognomonic genetic abnormality defining an unusual subset of actin-positive, perivascular myoid tumors, known as "pericytoma with the t(7;12) translocation." In addition, GLI1 oncogenic activation through a related MALAT1-GLI1 gene fusion has been recently reported in 2 unrelated gastric tumors, namely plexiform fibromyxoma and gastroblastoma. Triggered by unexpected targeted RNA-sequencing results detecting GLI1-related fusions in a group of malignant neoplasms with round to epithelioid morphology, and frequently strong S100 protein immunoreactivity, we investigated their clinicopathologic features in relation to other known pathologic entities sharing similar genetics...
January 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29303514/depletion-of-s100a4-stromal-cells-does-not-prevent-hcc-development-but-reduces-the-stem-cell-like-phenotype-of-the-tumors
#14
Jingjing Jiao, Álvaro González, Heather L Stevenson, Mihai Gagea, Hikaru Sugimoto, Raghu Kalluri, Laura Beretta
There is a pressing need for the development of novel approaches to treat and prevent hepatocellular carcinoma (HCC). The S100 calcium-binding protein S100A4 is associated with poor prognosis and metastasis in several human cancers. In addition, a role for S100A4 in modulating cancer-initiating cells stemness properties was recently proposed in head and neck and gastric cancers. Whether S100A4+ stromal cells contribute to tumor onset remains, however, an unanswered question. To address that question, we generated a new mouse model allowing for the depletion of S100A4+ cells in a mouse model of HCC with stemness properties, by crossing mice with hepatic deletion of phosphatase and tensin homolog (PTEN) with mice expressing viral thymidine kinase under the control of S100A4 promoter...
January 5, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29291592/improving-sensitivity-of-a-miniaturized-label-free-electrochemical-biosensor-using-zigzag-electrodes
#15
Yi-Ching Kuo, Chih-Kung Lee, Chih-Ting Lin
Cardiovascular disease (CVD) is a leading cause of death among chronic diseases worldwide. Therefore, it is important to be able to detect CVD biomarkers early so that patients can be diagnosed properly and begin treatment as soon as possible. To detect biomarkers more conveniently, point-of-care (PoC) biosensors, which are easy to use and are of low cost, are becoming even more necessary. This paper focuses on developing a label-free electrochemical biosensor with high sensitivity for PoC applications to detect CVD biomarkers such as S100 beta proteins and C-reactive proteins (CRP)...
December 2, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29290768/modulated-electro-hyperthermia-induced-loco-regional-and-systemic-tumor-destruction-in-colorectal-cancer-allografts
#16
Tamas Vancsik, Csaba Kovago, Eva Kiss, Edina Papp, Gertrud Forika, Zoltan Benyo, Nora Meggyeshazi, Tibor Krenacs
Background: Modulated electro-hyperthermia (mEHT), a non-invasive intervention using 13.56 MHz radiofrequency, can selectively target cancers due to their elevated glycolysis (Warburg-effect), extracellular ion concentration and conductivity compared to normal tissues. We showed earlier that mEHT alone can provoke apoptosis and damage associated molecular pattern (DAMP) signals in human HT29 colorectal cancer xenografts of immunocompromised mice. Materials: Here we tested the mEHT induced stress and immune responses in C26 colorectal cancer allografts of immunocompetent (BALB/c) mice between 12-72 h post-treatment...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29290325/-adenomyoepithelioma-of-the-breast-report-of-four-cases-and-literature-review
#17
Cristina Díaz Del Arco, Lourdes Estrada Muñoz, Alejandro Pascual Martín, Adela Pelayo Alarcón, David de Pablo Velasco, Luis Ortega Medina
Adenomyoepitheliomas of the breast are infrequent tumors with a variable histological appearance, and they can mimic several epithelial, myoepithelial and biphasic lesions of the breast. We have reviewed four cases of adenomyoepithelioma of the breast diagnosed between 2005 and 2015 in our institution (Hospital Clínico San Carlos). Mean age was 57years. All lesions were solid irregular masses located in the upper quadrants (3 of them in the right breast and one in the left), with an average size of 13mm. Microscopically 2 of them were tubular and the remaining 2 were lobulated subtypes...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29288747/magnesium-sulfate-attenuates-brain-edema-by-lowering-aqp4-expression-and-inhibits-glia-mediated-neuroinflammation-in-a-rodent-model-of-eclampsia
#18
Xiaolan Li, Huishu Liu, Yuanyuan Yang
Eclampsia is characterized by high morbidity and mortality wordwide. Magnesium sulfate ( MgSO4 ) is used frequently as a prophylaxis for eclamptic seizure in clinical settings. However, the underlying mechanism is less studied, we have previously demonstrated that MgSO4 pretreatment decreases eclampsia-like seizure threshold. Here, we further evaluated the hypothesis that MgSO4 exert neuroprotective actions in eclampsia-like rats model by ameliorating neuroinflammation and brain edema. In this study, the eclampsia-like model was established by administering lipopolysaccharide plus pentylenetetrazol in pregnant Sprague-Dawley rats...
December 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29287310/high-grade-transformation-dedifferentiation-of-an-adenoid-cystic-carcinoma-of-the-minor-salivary-gland-to-myoepithelial-carcinoma
#19
So Tando, Toshitaka Nagao, Kaori Kayano, Shinji Fushiki, Kyoko Itoh
High-grade transformation (HGT)/dedifferentiation is an unusual phenomenon in salivary gland carcinomas. Here we report a case of adenoid cystic carcinoma (ACC) with HGT/dedifferentiation to myoepithelial carcinoma, occurring in the epipharynx of a 42-year-old woman. The surgically resected tumor was a pedunculated mass, 31 × 25 mm in size, which had two histologically distinct carcinomatous areas, including a high-grade sarcomatoid area composed of pleomorphic spindle cells and an area consisting of low-grade typical ACC...
December 29, 2017: Pathology International
https://www.readbyqxmd.com/read/29287144/enhanced-biopharmaceutical-performance-of-rivaroxaban-through-polymeric-amorphous-solid-dispersion
#20
Sunita Metre, Sumit Mukesh, Sanjaya K Samal, Mahesh Chand, Abhay T Sangamwar
Rivaroxaban (RXB) is an orally active direct inhibitor of the activated serine protease Factor Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been characterized in-vitro as a substrate for the active, non-saturable efflux via P-gp transporter, limiting its high permeability. Therefore, role of P-gp inhibiting polymers in enhancing the biopharmaceutical performance of RXB by preparing polymeric amorphous solid dispersion and subsequent improvement in solubility and permeability was investigated...
December 29, 2017: Molecular Pharmaceutics
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