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https://www.readbyqxmd.com/read/28716587/botulinum-neurotoxin-a-promotes-functional-recovery-after-peripheral-nerve-injury-by-increasing-regeneration-of-myelinated-fibers
#1
Stefano Cobianchi, Jessica Jaramillo, Siro Luvisetto, Flaminia Pavone, Xavier Navarro
The injection of safe doses of botulinum neurotoxin A (BoNT/A) have been reported to be useful for the treatment of neuropathic pain, but it is still unknown how functional recovery is induced after peripheral nerve injury. We evaluated the effects of intranerve application of BoNT/A, on regeneration and sensorimotor functional recovery in partial and complete peripheral nerve injuries in the mouse. After sciatic nerve crush (SNC) and intranerve delivery of BoNT/A (15 pg), axonal regeneration was measured by nerve pinch test at different days...
July 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28712719/ages-rages-and-s-rage-friend-or-foe-for-cancer
#2
REVIEW
Saheem Ahmad, Hamda Khan, Zeba Siddiqui, Mohd Yasir Khan, Shahnawaz Rehman, Uzma Shahab, Tatyana Godovikova, Vladimir Silnikov, Moinuddin
Impaired awareness of glycation biology in cancer initiation and progression is one of the fundamental reasons for its meticulous investigation of the molecules involved in signalling pathway. Glycation of biological macromolecules results in the progression of advanced glycation end-products (AGEs) that proliferates the process of carcinogenesis by activation of transcription factors and release of cytokines. The receptor for advanced glycation end-products (RAGEs) with the binding of its different ligands like; AGEs, HMGB1 and S100 activate the signalling arrays...
July 13, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28712636/human-exoproteome-in-acute-apical-abscesses
#3
Cristiane F Alfenas, Tiago A O Mendes, Humberto J O Ramos, Fernanda P Bruckner, Henrique S Antunes, Isabela N Rôças, José F Siqueira, José C Provenzano
INTRODUCTION: An acute apical abscess is a severe response of the host to massive invasion of the periapical tissues by bacteria from infected root canals. Although many studies have investigated the microbiota involved in the process, information on the host factors released during abscess formation is scarce. The purpose of this study was to describe the human exoproteome in samples from acute apical abscesses. METHODS: Fourteen pus samples were obtained by aspiration from patients with an acute apical abscess...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28709789/extra-axial-chordoma-of-the-hand
#4
Alexander Bitzer, Edward F McCarthy, Carol D Morris
Chordomas are low-grade malignant tumors that are locally aggressive and have the potential to metastasize. They most often occur in the sacrococcygeal and spheno-occipital portions of the vertebral column. Morphologically similar tumors have been found outside the axial skeleton and are referred to as extra-axial chordomas. Several case reports have described the radiologic, microscopic, and immunologic profiles of these tumors and their similarities to axial chordomas. The authors report a 24-year-old man who presented with a mass in his left hand and underwent surgical excision...
July 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28707354/additive-neurogenesis-supported-by-multiple-stem-cell-populations-mediates-adult-spinal-cord-development-a-spatio-temporal-statistical-mapping-analysis-in-a-teleost-model-of-indeterminate-growth
#5
Ruxandra F Sîrbulescu, Iulian Ilieş, Annette Meyer, Günther K H Zupanc
The knifefish Apteronotus leptorhynchus exhibits indeterminate growth throughout adulthood. This phenomenon extends to the spinal cord, presumably through the continuous addition of new neurons and glial cells. However, little is known about the developmental dynamics of cells added during adult growth. The present work characterizes the structural and functional development of the adult spinal cord in this model organism through a comprehensive quantitative analysis of the spatial and temporal dynamics of new cells at various developmental stages...
July 13, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28704797/knockout-of-rage-ameliorates-mainstream-cigarette-smoke-induced-airway-inflammation-in-mice
#6
Mei Chen, Tao Wang, Yongchun Shen, Dan Xu, Xiaoou Li, Jing An, Jiajia Dong, Diandian Li, Fuqiang Wen, Lei Chen
BACKGROUND: The receptor for advanced glycation end products (RAGE), a multiligand receptor, has been proved to be implicated in inflammatory responses in chronic obstructive pulmonary disease (COPD). In this study, we investigated the role of RAGE in cigarette smoke (CS)-induced airway inflammation in COPD. METHODS: Wild-type (WT) and RAGE gene knockout (KO) mice were exposed to mainstream CS or room air for 2h twice daily, 6days per week for consecutive 4weeks...
July 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28699196/cytokeratin-positive-folliculo-stellate-cells-in-chicken-adenohypophysis
#7
Shotaro Nishimura, Miyu Yamashita, Takane Kaneko, Fuminori Kawabata, Shoji Tabata
Folliculo-stellate (FS) cells are non-endocrine cells found in the adenohypophysis and are identified in many animals by the S100 protein marker. Although keratin is another FS marker in several animals, there is no information on localization of keratin in the avian adenohypophysis. In this study, localization of cytokeratin in chicken adenohypophyseal cells was investigated immunohistochemically. Basic cytokeratin (bCK)-positive cells were arranged radially in the cell cords with their cytoplasmic processes reaching the basal lamina...
July 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28697655/functional-ulnar-nerve-paraganglioma-first-documented-occurrence-in-the-extremity-with-hitherto-undescribed-associated-extensive-glomus-cell-hyperplasia-and-tumorlet-formation
#8
Louis Tsun Cheung Chow, Michael Ho Ming Chan, Simon Kwok Chuen Wong
Extra-adrenal paraganglioma has never been described in the extremities. A 34-year-old woman complained of an enlarging mass in the right forearm for 18 months. Imaging showed a circumscribed vascular tumor attached to the ulnar nerve; biopsy revealed features of paraganglioma. The resected tumor consisted of zellballen pattern of chief cells staining positively for chromogranin with surrounding S100-positive sustentacular cells. The chief cells contained many neurosecretory granules and mitochondria, whereas the sustentacular cells contained a large amount of rough endoplasmic reticulum and some microfilaments...
July 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28694020/transdifferentiation-of-brain-derived-neurotrophic-factor-bdnf-secreting-mesenchymal-stem-cells-significantly-enhance-bdnf-secretion-and-schwann-cell-marker-proteins
#9
Metzere Bierlein De la Rosa, Anup D Sharma, Surya K Mallapragada, Donald S Sakaguchi
The use of genetically modified mesenchymal stem cells (MSCs) is a rapidly growing area of research targeting delivery of therapeutic factors for neuro-repair. Cells can be programmed to hypersecrete various growth/trophic factors such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) to promote regenerative neurite outgrowth. In addition to genetic modifications, MSCs can be subjected to transdifferentiation protocols to generate neural cell types to physically and biologically support nerve regeneration...
July 7, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28693201/s100p-is-associated-with-proliferation-and-migration-in-nasopharyngeal-carcinoma
#10
Yueyang Liu, Chengyu Wang, Xiaodong Shan, Jian Wu, Huanhai Liu, Haibin Liu, Jiping Zhang, Weihua Xu, Zhirong Sha, Jin He, Jingping Fan
In the present study, the function of S100 calcium binding protein P (S100P) in the C666-1 nasopharyngeal carcinoma (NPC) cell line was examined. The levels of S100P protein in NPC tissues were analyzed using immunohistochemistry, and small interfering RNA silenced S100P expression in C666-1 cells. Subsequently, cell proliferation, colony formation, migration and wound-healing assays were performed in order to assess whether the knockdown of S100P was able to influence the biological behavior of C666-1 cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690172/managing-colonic-inflammation-associated-gut-derangements-by-systematically-optimised-and-targeted-ginger-extract-lactobacillus-acidophilus-loaded-pharmacobiotic-alginate-beads
#11
Parneet Kaur Deol, Pragyanshu Khare, Dhirendra Pratap Singh, Girish Soman, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Indu Pal Kaur
Presently, we explore a cobiotic- ginger extract (GE; antioxidant-antiinflammatory) and Lactobacillus acidophilus (LAB, probiotic), for control of oxidative-stress, inflammation and dysbiosis mediated gut ailments. Since orally administered LAB looses viability while GE is a gastric irritant with poor ADME, we encapsulated them into calcium-alginate beads. Water-loving, viscolysing, and osmotic-building effects of polyethylene glycol were used to address poor probiotic encapsulation (≤10%) by effective sealing of numerous fine voids formed in the alginate gel...
July 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28688902/serum-s100-calcium-binding-protein-a4-improves-the-diagnostic-accuracy-of-transient-elastography-for-assessing-liver-fibrosis-in-hepatitis-b
#12
Li-Bo Yan, Qing-Bo Zhang, Xia Zhu, Min He, Hong Tang
AIM: The diagnostic performance of Fibroscan might be improved when combined with other serum fibrosis related markers. Previous study has demonstrated that S100A4 expression is associated with liver fibrosis in humans with hepatitis. This study aimed to clarify diagnostic accuracy of serum S100A4 levels for significant liver fibrosis in patients with chronic hepatitis B (CHB), and develop a combined algorithm of liver stiffness measurement (LSM) and S100A4 to predict significant liver fibrosis in CHB...
July 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28687035/effect-of-eudragit-s100-nanoparticles-and-alginate-chitosan-encapsulation-on-the-viability-of-lactobacillus-acidophilus-and-lactobacillus-rhamnosus
#13
Fereshteh Ansari, Hadi Pourjafar, Vahid Jodat, Javad Sahebi, Amir Ataei
In this study, we examined a novel method of microencapsulation with calcium alginate-chitosan and Eudragit S100 nanoparticles for the improving viability of probiotic bacteria, Lactobacillus acidophilus and Lactobacillus rhamnosus. Extrusion technique was carried out in microencapsulation process. The viability of two probiotics in single coated beads (with only chitosan), double coated beads (with chitosan and Eudragit nanoparticles), and as free cells (unencapsulated) were conducted in simulated gastric juice (pH 1...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28683589/infantile-ntrk-associated-mesenchymal-tumors
#14
Jessica L Davis, Christina M Lockwood, Katie Albert, Karen Tsuchiya, Douglas S Hawkins, Erin R Rudzinski
Pediatric fibroblastic/myofibroblastic lesions are a relatively common group of tumors with varying morphologies, for which the molecular mechanisms are becoming increasingly well characterized. Congenital infantile fibrosarcoma (CIFS), perhaps the most well studied of these lesions is characterized by a recurrent ETV6-NTRK3 gene fusion. However, a notable subset of locally aggressive congenital/infantile soft tissue lesions with similar morphologic features to CIFS, have not to-date, shown evidence of any canonical molecular aberration...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28682946/cerebral-alterations-following-experimental-multiple-trauma-and-hemorrhagic-shock
#15
Nina Vogt, Christiane Herden, Elke Roeb, Martin Roderfeld, Daphne Eschbach, Thorsten Steinfeldt, Hinnerk Wulf, Steffen Ruchholtz, Eberhard Uhl, Karsten Schöller
Multiple trauma (MT) associated with hemorrhagic shock (HS) might lead to cerebral hypoperfusion and brain damage. We investigated cerebral alterations using a new porcine MT/HS model without traumatic brain injury (TBI) and assessed the neuroprotective properties of mild therapeutic hypothermia. Male pigs underwent standardized MT with HS (45% or 50% loss of blood volume) and resuscitation after 90/120 minutes (T90/T120). In additional groups (TH90/TH120) mild hypothermia (33°C) was induced following resuscitation...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28681747/correlation-of-ubiquitin-c-terminal-hydrolase-and-s100%C3%AE-with-cognitive-deficits-in-young-adults-with-mild-traumatic-brain-injury
#16
Subir Dey, Jagathlal Gangadharan, Akhil Deepika, J Keshav Kumar, Rita Christopher, Shruthi S Ramesh, B Indira Devi, Dhaval P Shukla
OBJECTIVE: To study the acute phase serum biomarkers in patients with mild traumatic brain injury (mTBI) and to correlate them with short term cognitive deficits. MATERIALS AND METHODS: This is a prospective observational study conducted at a tertiary care center for neurotrauma. The participants included patients with mTBI (n = 20) and age, gender, and education-status matched healthy controls (n = 20). In both the groups, the serum concentrations of biomarkers ubiquitin C terminal hydrolase (UCH-L1) and S100 calcium-binding protein B (S100B) were measured...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28680582/estrogen-receptor-dependent-attenuation-of-hypoxia-induced-changes-in-the-lung-genome-of-pulmonary-hypertension-rats
#17
Andrea L Frump, Marjorie E Albrecht, Jeanette N McClintick, Tim Lahm
17β-estradiol (E2) exerts complex and context-dependent effects in pulmonary hypertension. In hypoxia-induced pulmonary hypertension (HPH), E2 attenuates lung vascular remodeling through estrogen receptor (ER)-dependent effects; however, ER target genes in the hypoxic lung remain unknown. In order to identify the genome regulated by the E2-ER axis in the hypoxic lung, we performed a microarray analysis in lungs from HPH rats treated with E2 (75 mcg/kg/day) ± ER-antagonist ICI182,780 (3 mg/kg/day). Untreated HPH rats and normoxic rats served as controls...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28669632/regulation-of-the-equilibrium-between-closed-and-open-conformations-of-annexin-a2-by-n-terminal-phosphorylation-and-s100a4-binding
#18
Péter Ecsédi, Bence Kiss, Gergő Gógl, László Radnai, László Buday, Kitti Koprivanacz, Károly Liliom, Ibolya Leveles, Beáta Vértessy, Norbert Jeszenői, Csaba Hetényi, Gitta Schlosser, Gergely Katona, László Nyitray
Annexin A2 (ANXA2) has a versatile role in membrane-associated functions including membrane aggregation, endo- and exocytosis, and it is regulated by post-translational modifications and protein-protein interactions through the unstructured N-terminal domain (NTD). Our sequence analysis revealed a short motif responsible for clamping the NTD to the C-terminal core domain (CTD). Structural studies indicated that the flexibility of the NTD and CTD are interrelated and oppositely regulated by Tyr24 phosphorylation and Ser26Glu phosphomimicking mutation...
June 21, 2017: Structure
https://www.readbyqxmd.com/read/28669319/serum-inflammatory-molecules-and-markers-of-neuronal-damage-in-alcohol-dependent-subjects-after-withdrawal
#19
Murielle Girard, Dominique Malauzat, Philippe Nubukpo
OBJECTIVES: Our aim is to describe changes in serum concentration for the proinflammatory factors TNF-α, IFN-gamma, IL-1beta, IL-8, IL-6, IL-10, IL-12, and MCP-1, for the satiety factor leptin and for factors associated with neuronal changes, neuron-specific enolase (NSE) and glial activation S100-beta protein (S100-β), and explore their association with abstinence in alcohol dependent subjects after withdrawal. METHODS: Serum sampling and clinical assessments from 115 alcohol-dependent subjects admitted to a psychiatric hospital for alcohol were repeated during the first 48 hours of withdrawal (M0) and 1, 2, 4 and 6 months (M1, M2, M4, M6) after...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28666451/autologous-chondrocyte-implantation-derived-synovial-fluids-display-distinct-responder-and-non-responder-proteomic-profiles
#20
Charlotte H Hulme, Emma L Wilson, Mandy J Peffers, Sally Roberts, Deborah M Simpson, James B Richardson, Pete Gallacher, Karina T Wright
BACKGROUND: Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do not respond well to this intervention. Identification of a reliable and accurate biomarker panel that can predict which patients are likely to respond well to ACI is needed in order to assign the patient to the most appropriate therapy. This study aimed to compare the baseline and mid-treatment proteomic profiles of synovial fluids (SFs) obtained from responders and non-responders to ACI...
June 30, 2017: Arthritis Research & Therapy
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