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https://www.readbyqxmd.com/read/29755896/bouveret-s-syndrome-literature-review
#1
REVIEW
Fady G Haddad, Wissam Mansour, Liliane Deeb
It was in 1896 that Bouveret's syndrome acquired its name after the French physician Leon Bouveret, who published two case reports in Revue de Medecin. Bouveret's syndrome describes gastric outlet obstruction secondary to an impacted gallstone. The gallstone reaches the small bowel through a bilioenteric fistula as a consequence of chronic inflammation and adherence between the biliary system and the bowels which increase the intraluminal pressure and leads to secondary wall ischemia and wall perforation with gallstone passage into the bowel...
March 10, 2018: Curēus
https://www.readbyqxmd.com/read/29745476/clinical-impact-of-optical-coherence-tomography-findings-on-culprit-plaque-in-acute-coronary-syndrome-the-oct-formidable-study-registry
#2
Mario Iannaccone, Geraud Souteyrand, Giampaolo Niccoli, Massimo Mancone, Gennaro Sardella, Corrado Tamburino, Christian Templin, Sebastiano Gili, Giacomo G Boccuzzi, Fabrizio D'Ascenzo
BACKGROUND: Aim of this study was to evaluate the clinical impact of the culprit plaque features assessed by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). METHODS: The OCT-FORMIDABLE register enrolled retrospectively all consecutive patients who perform OCT on culprit plaque in patients with ACS in nine European centres. The primary endpoint was the prevalence of culprit plaque rupture (CPR) in patients experiencing major adverse cardiovascular events (MACEs)...
May 10, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29740174/rett-syndrome-insights-into-genetic-molecular-and-circuit-mechanisms
#3
REVIEW
Jacque P K Ip, Nikolaos Mellios, Mriganka Sur
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT have greatly advanced our understanding of the function and regulation of the multifunctional protein MeCP2. Here, we review recent advances in understanding how loss of MeCP2 impacts different stages of brain development, discuss recent findings demonstrating the molecular role of MeCP2 as a transcriptional repressor, assess primary and secondary effects of MeCP2 loss and examine how loss of MeCP2 can result in an imbalance of neuronal excitation and inhibition at the circuit level along with dysregulation of activity-dependent mechanisms...
May 8, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29734385/growth-patterns-of-survivors-of-retinoblastoma-treated-with-ophthalmic-artery-chemosurgery
#4
Sruti S Akella, Jasmine H Francis, Andrea Knezevic, Irina Ostrovnaya, Y Pierre Gobin, Danielle Friedman, Edith Guarini, Lindsey Eibeler, Federica Catalanotti, David H Abramson
Although studies from pediatric cancers (largely acute lymphoblastic leukemia) have shown that patients undergoing systemic chemotherapy may experience decreased growth velocity during the treatment phase, no such data exist for retinoblastoma patients treated with systemic chemotherapy or ophthalmic artery chemosurgery (OAC). The purpose of this study is to report growth patterns of our retinoblastoma (Rb) population who were treated with OAC in a retrospective, single center (Memorial Sloan Kettering Cancer Center) review of 341 patients treated between 2006 and 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29731633/impact-of-time-of-initiation-of-once-monthly-paliperidone-palmitate-in-hospitalized-asian-patients-with-acute-exacerbation-of-schizophrenia-a-post-hoc-analysis-from-the-prevail-study
#5
Huafang Li, Yan Li, Yu Feng, Jianmin Zhuo, Ibrahim Turkoz, Maju Mathews, Wilson Tan
Purpose: To evaluate the differences in efficacy and safety outcomes in acute exacerbating schizophrenia patients between 2 subgroups (≤1 week and >1 week), differing in time interval from hospitalization to time of initiation of once-monthly paliperidone palmitate. Patients and methods: PREVAIL was a multicenter, single-arm, open-label, prospective Phase IV study in hospitalized Asian patients (either sex, aged 18-65 years) diagnosed with schizophrenia ( Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition)...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29730741/is-balneotherapy-effective-for-fibromyalgia-results-from-a-6-month-double-blind-randomized-clinical-trial
#6
Antonella Fioravanti, Patrizia Manica, Roberto Bortolotti, Gabriele Cevenini, Sara Tenti, Giuseppe Paolazzi
The aim of this study was to assess the efficacy and tolerability of balneotherapy (BT) in patients with primary fibromyalgia syndrome (FS). In a prospective, randomized, controlled, double-blind trial with a 6-month follow-up, 100 FS patients were randomized to receive a cycle of BT with highly mineralized sulfate water (BT group) or with tap water (control group). Clinical assessments were performed at screening visit, at basal time, and after treatment (2 weeks, 3 and 6 months). The primary outcome measures were the change of global pain on the Visual Analogue Scale (VAS) and Fibromyalgia Impact Questionnaire total score (FIQ-Total) from baseline to 15 days...
May 5, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29721207/impact-of-mutational-studies-on-the-diagnosis-and-the-outcome-of-high-risk-myelodysplastic-syndromes-and-secondary-acute-myeloid-leukemia-patients-treated-with-5-azacytidine
#7
Marta Cabezón, Joan Bargay, Blanca Xicoy, Olga García, Josep Borrás, Mar Tormo, Sílvia Marcé, Carme Pedro, David Valcárcel, Maria-José Jiménez, Ramón Guàrdia, Laura Palomo, Salut Brunet, Ferran Vall-Llovera, Antoni Garcia, Evarist Feliu, Lurdes Zamora
Myelodysplastic syndromes (MDS) are stem cell disorders caused by various gene abnormalities. We performed targeted deep sequencing in 39 patients with high-risk MDS and secondary acute myeloid leukemia (sAML) at diagnosis and follow-up (response and/or relapse), with the aim to define their mutational status, to establish if specific mutations are biomarkers of response to 5-azacytidine (AZA) and/or may have impact on survival. Overall, 95% of patients harbored at least one mutation. TP53, DNMT3A and SRSF2 were the most frequently altered genes...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29719933/prospective-evaluation-of-the-effect-of-deferasirox-on-hematologic-response-in-transfusion-dependent-patients-with-low-risk-mds-and-iron-overload
#8
C Rose, C Lenoir, E Gyan, M Hacini, S Amé, B Corront, O Beyne-Rauzy, D Adiko, E Loppinet, N Ali-Ammar, K Laribi, E Wattel, F Dreyfus, C S Roué, S Cheze
OBJECTIVES: To assess the reduction of transfusions rate in transfusion-dependent patients with low-risk myelodysplastic syndrome (MDS) with iron overload treated with deferasirox. METHODS: Prospective observational study. Primary endpoint was reduction in transfusion requirements (RTR) at 3 months, (assessed on 8-week period). Secondary endpoints were hematologic improvement according IWG 2006 criteria at 3, 6, 12 months. RESULTS: Fifty-seven patients were evaluable...
May 2, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29706622/ambient-particulate-matter-air-pollution-associated-with-acute-respiratory-distress-syndrome-in-guangzhou-china
#9
Hualiang Lin, Jun Tao, Haidong Kan, Zhengmin Qian, Ailan Chen, Yaodong Du, Tao Liu, Yonghui Zhang, Yongqing Qi, Jianjun Ye, Shuangming Li, Wanglin Li, Jianpeng Xiao, Weilin Zeng, Xing Li, Katherine A Stamatakis, Xinyu Chen, Wenjun Ma
Limited evidence exists concerning the impact of particulate pollution on acute respiratory distress syndrome (ARDS). We examined the effects of particulate pollution on emergency ambulance dispatches (EAD) for ARDS in Guangzhou, China. Daily air pollution concentrations for PM10 , PM2.5 , and PM1 , as well as PM2.5 chemical compositions, were available from a central air monitoring station. The association between incident ARDS and air pollution on the concurrent and previous 5 days was estimated by an over-dispersed Poisson generalized additive model controlling for meteorological factors, temporal trends, public holidays and day of the week...
April 30, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29705177/the-impact-of-exercise-and-vitamin-d-supplementation-on-physical-function-in-community-dwelling-elderly-individuals-a-randomized-trial
#10
Kana Aoki, Mayumi Sakuma, Naoto Endo
BACKGROUND: We investigated the impact of exercise and vitamin D supplementation on physical function and locomotor dysfunction in community-dwelling elderly individuals. METHODS: In total, 148 community-dwelling elderly individuals (aged ≥60 years) who were not taking osteoporosis medications participated in a 24-week intervention. The participants were randomly divided into an exercise group, vitamin D group, and exercise and vitamin D group. The participants and outcome-assessing staff were not blinded to group assignment...
April 25, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29703090/using-eye-tracking-technology-for-communication-in-rett-syndrome-perceptions-of-impact
#11
Kelli Vessoyan, Gill Steckle, Barb Easton, Megan Nichols, Victoria Mok Siu, Janette McDougall
Studies have investigated the use of eye-tracking technology to assess cognition in individuals with Rett syndrome, but few have looked at this access method for communication for this group. Loss of speech, decreased hand use, and severe motor apraxia significantly impact functional communication for this population. Eye gaze is one modality that may be used successfully by individuals with Rett syndrome. This multiple case study explored whether using eye-tracking technology, with ongoing support from a team of augmentative and alternative communication (AAC) therapists, could help four participants with Rett syndrome meet individualized communication goals...
April 27, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29696940/assessment-of-a-topical-product-based-on-polysulfated-glycosaminoglycan-as-an-adjuvant-in-the-treatment-of-acute-stp-and-stasis-dermo-hypodermitis
#12
Angelo Santoliquido
BACKGROUND: Superficial thrombophlebitis (STP) is a relatively frequent pathology characterized by possible extension to the deep venous circulation, with notable local inflammatory reaction which is treated by subcutaneous administration of Fondaparinux. Stasis dermo- hypodermitis is characterized by cutaneous hyperpigmentation and eczema, treatment for which consists of the use of drugs targeting endothelial cells (mesoglycan, FFPM, sulodexide). In this study we evaluated the impact of local application of a mixture of semi-synthetic polysulfated glycosaminoglycans on the regression rate of STP and dermo-hypodermitis in patients treated with best medical therapy (BMT)...
April 24, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29684136/effects-of-a-group-mediated-exercise-and-dietary-intervention-in-the-treatment-of-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-results-from-the-idea-p-trial
#13
Brian C Focht, Alexander R Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M Fairman, Jennifer M Thomas-Ahner, Jackie Buell, J Paul Monk, Amir Mortazavi, Steven K Clinton
Background: Although androgen-deprivation therapy (ADT) is the foundation of treatment for prostate cancer, the physiological impacts of ADT result in functional decline and enhanced risk of chronic disease and metabolic syndrome. Purpose: The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is a single-blind, randomized, pilot trial comparing the effects of a group-mediated, cognitive-behavioral (GMCB) exercise and dietary intervention (EX+D) with those of a standard-of-care (SC) control during the treatment of prostate cancer patients undergoing ADT...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29665126/prophylactic-therapy-with-omeprazole-for-prevention-of-equine-gastric-ulcer-syndrome-egus-in-horses-in-active-training-a-meta-analysis
#14
L V Mason, J R Moroney, R J Mason
BACKGROUND: Guidelines regarding the impact and value of prophylaxis or maintenance therapy in Equine Gastric Ulcer Syndrome (EGUS) are not well established or defined. The merits and the magnitude of effects of prophylaxis for spontaneous or recurrent squamous gastric ulceration in horses in training are uncertain. OBJECTIVES: To pool data from randomised controlled trials (RCTs) to eliminate reporting bias and evaluate the efficacy of prophylactic omeprazole in the prevention of EGUS in training horses, and secondarily to compare prophylactic dosages of omeprazole...
April 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29659956/polyphenols-have-no-impact-on-endothelial-function-in-patients-with-obstructive-sleep-apnea-a-randomized-controlled-trial
#15
Wojciech Trzepizur, Vanessa Bironneau, Sylvain Recoquillon, Pascaline Priou, Nicole Meslier, Jean-François Hamel, Samir Henni, Astrid Darsonval, Khaled Messaoudi, Maria Carmen Martínez, Ramaroson Andriantsitohaina, Frédéric Gagnadoux
Background: Endothelial dysfunction, a pathophysiologic determinant of atherogenesis, has been found to occur in obstructive sleep apnea syndrome (OSA) and is improved by continuous positive airway pressure (CPAP). However, the efficacy of CPAP therapy is limited by variable adherence. Alternative treatment strategies are needed. The impact of polyphenols on endothelial function has never been evaluated in OSA. Objective: We evaluated the impact of 1-mo supplementation with grape juice polyphenols (GJPs) on the reactive hyperemia index (RHI), a validated measure of endothelial function in patients with severe OSA...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29627296/relationship-between-lipoprotein-subfraction-cholesterol-and-residual-risk-for-cardiovascular-outcomes-a-post-hoc-analysis-of-the-aim-high-trial
#16
Peter P Toth, Steven R Jones, April Slee, Jerome Fleg, Santica M Marcovina, Megan Lacy, Ruth McBride, William E Boden
BACKGROUND: The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial failed to demonstrate incremental clinical benefit of extended-release niacin (ERN) in 3414 statin-treated patients with established cardiovascular (CV) disease who had low baseline levels of high-density lipoprotein cholesterol (HDL-C) as compared to placebo. A previous secondary analysis suggested that ERN provided outcome benefits in ERN-treated patients with high triglycerides (TGs; >200 mg/dL) and very low HDL-C (<32 mg/dL) at baseline...
March 9, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29623097/renal-effects-of-non-tenofovir-antiretroviral-therapy-in-patients-living-with-hiv
#17
REVIEW
Milena M McLaughlin, Aimee J Guerrero, Andrew Merker
A review of literature published regarding non-tenofovir antiretroviral agents causing renal adverse effects was conducted. The literature involving renal adverse effects and antiretroviral therapy is most robust with protease inhibitors, specifically atazanavir and indinavir, and includes reports of crystalluria, leukocyturia, nephritis, nephrolithiasis, nephropathy and urolithiasis. Several case reports describe potential nephropathy (including Fanconi syndrome) secondary to administration of abacavir, didanosine, lamivudine and stavudine...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29619769/multiple-hormonal-and-metabolic-deficiency-syndrome-in-chronic-heart-failure-rationale-design-and-demographic-characteristics-of-the-t-o-s-ca-registry
#18
E Bossone, M Arcopinto, M Iacoviello, V Triggiani, F Cacciatore, C Maiello, G Limongelli, D Masarone, F Perticone, A Sciacqua, P Perrone-Filardi, A Mancini, M Volterrani, O Vriz, R Castello, A Passantino, M Campo, P A Modesti, A De Giorgi, I Monte, A Puzzo, A Ballotta, L Caliendo, R D'Assante, A M Marra, A Salzano, T Suzuki, A Cittadini
Recent evidence supports the concept that progression of chronic heart failure (CHF) depends upon an imbalance of catabolic forces over the anabolic drive. In this regard, multiple hormonal deficiency syndrome (MHDS) significantly has impacts upon CHF progression, and is associated with a worse clinical status and increased mortality. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Therapy in Heart Failure) Registry (clinicaltrial.gov = NCT02335801) tests the hypothesis that anabolic deficiencies reduce survival in a large population of mild-to-moderate CHF patients...
April 4, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29614993/impact-of-resistance-training-on-body-composition-and-metabolic-syndrome-variables-during-androgen-deprivation-therapy-for-prostate-cancer-a-pilot-randomized-controlled-trial
#19
Jacqueline K Dawson, Tanya B Dorff, E Todd Schroeder, Christianne J Lane, Mitchell E Gross, Christina M Dieli-Conwright
BACKGROUND: Prostate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of metabolic syndrome (MetS). Resistance training can increase lean mass, reduce body fat, and improve physical function and quality of life, but no exercise interventions in prostate cancer patients on ADT have concomitantly improved body composition and MetS. This pilot trial investigated 12 weeks of resistance training on body composition and MetS changes in prostate cancer patients on ADT...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29607525/remission-of-loss-of-control-eating-and-changes-in-components-of-the-metabolic-syndrome
#20
Lisa M Shank, Marian Tanofsky-Kraff, Rachel M Radin, Lauren B Shomaker, Denise E Wilfley, Jami F Young, Sheila Brady, Cara H Olsen, James C Reynolds, Jack A Yanovski
OBJECTIVE: Pediatric loss of control (LOC) eating prospectively predicts the worsening of metabolic syndrome components. However, it is unknown if remission of LOC eating is associated with improvements in metabolic health. Therefore, we conducted a secondary analysis of a trial that enrolled adolescent girls with LOC eating, examining whether LOC remission (vs. persistence) at end-of-treatment was associated with changes in metabolic syndrome components at 6-month follow-up. METHOD: One hundred three adolescent girls (age 14...
April 1, 2018: International Journal of Eating Disorders
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