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https://www.readbyqxmd.com/read/29163952/in-office-arthroscopy-for-the-evaluation-of-chronic-knee-pain-a-case-report
#1
Jacob A West, Nirav H Amin
This is a case report detailing the use of in-office needle arthroscopy (mi-eye 2™) in a patient with chronic knee pain and inconclusive magnetic resonance imaging findings. The patient is a 40-year-old male who presented to our clinic after an extended history of right knee pain along the medial aspect with previous failed treatments. Magnetic resonance imaging without contrast had demonstrated full-thickness chondral fissuring of the lateral patellar facet, mild abnormal signals of the proximal patellar tendon and Hoffa's fat pad, and intact anterior cruciate ligament and posterior cruciate ligament...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29162378/arthroscopic-medial-meniscal-repair-with-or-without-concurrent-anterior-cruciate-ligament-reconstruction-a-subgroup-analysis
#2
Erdal Uzun, Abdulhamit Misir, Turan Bilge Kizkapan, Mustafa Ozcamdalli, Soner Akkurt, Ahmet Guney
BACKGROUND: There are few large-scale, long-term studies comparing medial meniscal repairs with or without concurrent anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 140 patients who underwent arthroscopic medial meniscal repair were divided into two groups: Group A, meniscus repair only and Group B, meniscus repair with concurrent ACL reconstruction. Clinical assessments in- cluded physical examination findings, Lysholm score, and the International Knee Documentation Committee (IKDC) form...
November 18, 2017: Knee
https://www.readbyqxmd.com/read/29145712/cartilage-microrna-dysregulation-during-the-onset-and-progression-of-mouse-osteoarthritis-is-independent-of-aggrecanolysis-and-overlaps-with-candidates-from-end-stage-human-disease
#3
Louise H W Kung, Varshini Ravi, Lynn Rowley, Constanza Angelucci, Amanda J Fosang, Katrina M Bell, Christopher B Little, John F Bateman
OBJECTIVE: To identify candidate microRNAs that potentially regulate the initiation and progression of osteoarthritis. METHODS: Osteoarthritis was induced in 10-12 week old male wild-type C57BL6 mice and in mice resistant to aggrecanase cleavage (Acan p.374ALGS→374NVYS) by destabilization of the medial meniscus (DMM). Osteoarthritis pathology was scored histologically. RNA from cartilage and subchondral bone were harvested in parallel by laser micro-dissection at 1 and 6 weeks post-surgery...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145286/bilateral-discoid-medial-meniscus-associated-with-meniscal-tears-and-hypoplasia-of-the-medial-femoral-condyle-a-case-report
#4
Hong-De Wang, Shi-Jun Gao
RATIONALE: Bilateral discoid medial menisci is an extremely rare abnormality of the knee joint. The presence of a discoid medial meniscus has been associated with magnetic resonance imaging (MRI) and radiographic changes in the tibial region, such as cupping of the medial tibial plateau and tibial physis collapse. While discoid medial meniscal tears with hypoplasia of the femoral medial condyles have not been previously reported. Herein, we report a case of bilateral discoid medial menisci associated with meniscal tears and femoral bone changes...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143973/effects-of-microrna-24-targeting-c-myc-on-apoptosis-proliferation-and-cytokine-expressions-in-chondrocytes-of-rats-with-osteoarthritis-via-mapk-signaling-pathway
#5
Yuan-Hao Wu, Wei Liu, Lei Zhang, Xiao-Ya Liu, Yi Wang, Bin Xue, Bin Liu, Ran Duan, Bo Zhang, Yang Ji
OBJECTIVE: To investigate whether microRNA-24 (miR-24) targeting C-myc affects chondrocytes of rats with osteoarthritis (OA) via the MAPK signaling pathway. METHODS: Thirty rats were assigned as a sham group and an OA group (established as OA rat models by cutting the anterior cruciate ligaments and removing 1/3 medial meniscus). TUNEL staining and immunohistochemistry were conducted for cell apoptosis index (AI) and positive expression rate of C-myc protein. Enzyme-linked immuno sorbent assay (ELISA) was carried out for serum level of IL-1β and TNF-α...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29143404/tool-for-osteoarthritis-risk-prediction-toarp-over-8-years-using-baseline-clinical-data-x-ray-and-mri-data-from-the-osteoarthritis-initiative
#6
Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Jan Neumann, Alexandra S Gersing, Martin Kretzschmar, Benedikt J Schwaiger, John A Lynch, Ursula Heilmeier, Nancy E Lane, Thomas M Link
BACKGROUND: Osteoarthritis (OA), a multifactorial disease causing joint degeneration, often leads to severe disability. The rising rates of disability highlight the need for implementing preventative measures at early stages of the disease, which would especially benefit subjects at high risk for OA development. PURPOSE: To develop a risk prediction tool for moderate-severe OA (TOARP) over 8 years based on subject characteristics, knee radiographs, and MRI data at baseline using data from the Osteoarthritis Initiative (OAI)...
November 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29112467/meniscectomy-and-resultant-articular-cartilage-lesions-of-the-knee-among-prospective-national-football-league-players-an-imaging-and-performance-analysis
#7
Jorge Chahla, Mark E Cinque, Jonathan A Godin, George Sanchez, George F Lebus, James M Whalen, Mark D Price, Nicholas I Kennedy, Gilbert Moatshe, Robert F LaPrade, Matthew T Provencher
BACKGROUND: The effect of prior meniscectomy and the resulting reduction in meniscal tissue on a potential National Football League (NFL) player's articular cartilage status and performance remain poorly elucidated. Purpose/Hypothesis: (1) To determine the epidemiology, imaging characteristics, and associated articular cartilage pathology of the knee among players with a previous meniscectomy who were participating in the NFL Combine and (2) to evaluate the effect of these injuries on performance as compared with matched controls...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29107695/contrast-enhanced-%C3%AE-ct-imaging-of-early-articular-changes-in-a-pre-clinical-model-of-osteoarthritis
#8
D S Reece, T Thote, A S P Lin, N J Willett, R E Guldberg
OBJECTIVE: The objective of this study was to characterize early osteoarthritis (OA) development in cartilage and bone tissues in the rat medial meniscus transection (MMT) model using non-destructive equilibrium partitioning of an ionic contrast agent micro-computed tomography (EPIC-μCT) imaging. Cartilage fibrillation, one of the first physiological developments in OA, was quantified in the rat tibial plateau as three-dimensional (3D) cartilage surface roughness using a custom surface-rendering algorithm...
October 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29103840/the-influence-of-full-thickness-chondral-defects-on-outcomes-following-meniscal-allograft-transplantation-a-comparative-study
#9
Bryan M Saltzman, Maximilian A Meyer, Timothy S Leroux, Matthew E Gilelis, Margot Debot, Adam B Yanke, Brian J Cole
PURPOSE: To compare a series of patients who underwent meniscus allograft transplantation (MAT) with full-thickness chondral defects (FTD) with those with no chondral defect (ND) with regard to the following: change in patient-reported outcomes (PROs) from baseline to 2-year follow-up and baseline to the final follow-up (including comparisons to minimal clinically important differences), complications and complication rates, reoperations and reoperation rates/timing, and failures and time to failure (revision MAT or conversion to total knee arthroplasty)...
November 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29103482/quantitative-evaluation-of-knee-cartilage-and-meniscus-destruction-in-patients-with-rheumatoid-arthritis-using-t1%C3%AF-and-t2-mapping
#10
Xiang Hong Meng, Zhi Wang, Li Guo, Xiu Chan Liu, Yu Wei Zhang, Ze Wei Zhang, Xin Long Ma
OBJECTIVE: To calculate T1ρ and T2 values of articular cartilage and menisci in knee joints of patients with RA, and compare the values between RA patients and healthy volunteers, to gain insight into the pathogenesis of cartilage and meniscus degradation in patients with RA. MATERIALS AND METHODS: Nine patients with RA and knee joints symptoms were enrolled in the study, twenty healthy volunteers without knee joint diseases were included as controls. Sagittal fat-saturated T1ρ and T2 mapping images were obtained on a 3T MR scanner (GE750, GE Healthcare, Waukesha, WI), using a dedicated 8-channel knee coil...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29102413/posteriorly-inserted-anterior-cruciate-ligament-in-knees-with-discoid-lateral-meniscus-corresponding-to-bony-morphological-characteristics-of-femoral-lateral-condyle
#11
Takao Minami, Hideyuki Koga, Ichiro Sekiya, Toshifumi Watanabe, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Takeshi Muneta
PURPOSE: Discoid meniscus often causes mechanical problems and needs surgical treatment at an early age. However, many aspects of its morphological development and changes remain unknown. The purpose of this study was to investigate the insertion of the femoral anterior cruciate ligament (ACL) via the behind-ACL approach and the morphology of the lateral femoral condyle to which the ACL attaches to clarify the morphological characteristics of the knee with discoid lateral meniscus (DLM)...
November 1, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29099888/medial-oblique-meniscomeniscal-ligament-of-knee
#12
Avijit Sharma, Jason Payne, M M Manring, David C Flanigan
An aberrant meniscus attachment was found in the setting of an anterior cruciate ligament injury. An anomalous cordlike attachment ran from the anterior horn of the medial meniscus to the posterior horn of the lateral meniscus through the intercondylar notch. Surgeons should be aware of the anatomical variability in the knee in order to provide the best care for their patients.
September 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29098324/increased-extrusion-and-icrs-grades-at-2-year-follow-up-following-transtibial-medial-meniscal-root-repair-evaluated-by-mri
#13
Daniel J Kaplan, Erin F Alaia, Andrew P Dold, Robert J Meislin, Eric J Strauss, Laith M Jazrawi, Michael J Alaia
PURPOSE: The purpose of the current study was to evaluate the short-term results of meniscal root repair surgery, assessing clinical and radiographic outcomes, utilizing MRI to assess root healing and extent of post-operative extrusion. METHODS: This was a single-center, retrospective study evaluating patients who had undergone a medial meniscus posterior root repair using a transtibial pullout technique with two locking cinch sutures. Demographic data were collected from patient charts...
November 2, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29093428/danshen-attenuates-cartilage-injuries-in-osteoarthritis-in-vivo-and-in-vitro-by-activating-jak2-stat3-and-akt-pathways
#14
Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang
Articular cartilage degradation is a main feature of osteoarthritis (OA). The effects of Danshen, a traditional Chinese herb, in mitigating cartilage damage have been reported before. This study was conducted to investigate the effects of Danshen on cartilage injuries in OA. Rabbit OA models were established by surgical destabilization of the medial meniscus and the anterior and posterior cruciate ligaments in the left knee joint. Injection of Danshen into the articular cavity attenuated OA cartilage destruction in vivo...
October 31, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29091874/aqueous-extract-of-codium-fragile-alleviates-osteoarthritis-through-the-mapk-nf-%C3%AE%C2%BAb-pathways-in-il-1%C3%AE-induced-rat-primary-chondrocytes-and-a-rat-osteoarthritis-model
#15
Sung-Min Moon, Seul Ah Lee, Seul Hee Han, Bo-Ram Park, Mi Suk Choi, Jae-Sung Kim, Su-Gwan Kim, Heung-Joong Kim, Hong Sung Chun, Do Kyung Kim, Chun Sung Kim
BACKGROUND: Codium fragile (Suringar) Hariot has been used as a potential remedy in traditional medicine because of its anti-inflammatory and anti-oxidant effects. Osteoarthritis is a chronic progressive joint disease, characterized by complex mechanisms related to inflammation and degeneration of articular cartilage. In this study, we aimed to evaluate the cartilage protective effect of an aqueous extract of Codium fragile (AECF) using rat primary chondrocytes and the osteoarthritis animal model induced by destabilization of the medial meniscus (DMM)...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29070587/ghrelin-protects-against-osteoarthritis-through-interplay-with-akt-and-nf-%C3%AE%C2%BAb-signaling-pathways
#16
Ruize Qu, Xiaomin Chen, Wenhan Wang, Cheng Qiu, Miaomiao Ban, Linlin Guo, Krasimir Vasilev, Jianying Chen, Weiwei Li, Yunpeng Zhao
Osteoarthritis (OA) is a common chronic degenerative disease characterized by degeneration in the joints and subsequent destruction of cartilage and bone, yet much remains to be elucidated regarding its molecular mechanism. Ghrelin is a recently discovered neuropeptide with anti-inflammatory actions, but it is unknown whether ghrelin is involved in OA. Human primary chondrocyte and cartilage samples were collected from patients with OA, and the expression pattern of ghrelin was assessed. Human chondrocyte and cartilage samples were stimulated with IL-1β and TNF-α, and exogenous ghrelin-alleviated disorganization of catabolism and anabolism were mediated by IL-1β and TNF-α...
October 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29065270/medial-meniscus-resection-increases-and-medial-meniscus-repair-preserves-anterior-knee-laxity-a-cohort-study-of-4497-patients-with-primary-anterior-cruciate-ligament-reconstruction
#17
Riccardo Cristiani, Erik Rönnblad, Björn Engström, Magnus Forssblad, Anders Stålman
BACKGROUND: There are still controversies regarding the effects on knee laxity of additional meniscus resection or repair in the setting of anterior cruciate ligament reconstruction (ACLR). Hypothesis/Purpose: The purpose was to determine the effects on knee laxity of resection or repair of medial meniscus (MM) or lateral meniscus (LM) injuries in the ACLR knee. The hypothesis was that patients with an additional meniscus resection would have significantly increased postoperative knee laxity versus that of an isolated ACLR, whereas patients with meniscus repair would have laxity comparable to that of an isolated ACLR...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29065035/the-effect-of-soft-tissue-injuries-on-clinical-outcomes-following-tibial-plateau-fracture-fixation
#18
Stephen J Warner, Matthew R Garner, Patrick C Schottel, Peter D Fabricant, Ryan R Thacher, Michael L Loftus, David L Helfet, Dean G Lorich
OBJECTIVE: The purpose of this study was to determine if ligamentous and meniscal injuries as determined by initial magnetic resonance imaging altered clinical outcomes following the fixation of tibial plateau fractures. DESIGN: Comparative cohort study. SETTING: Academic level I trauma center. PATIENTS/PARTICIPANTS: Eighty-two patients from a prospective database of operatively treated tibial plateau fractures met the inclusion criteria, which consisted of injury radiographs, preoperative knee MRI, and a minimum of twelve months of clinical outcomes...
October 14, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29054695/where-does-meniscal-damage-progress-most-rapidly-an-analysis-using-three-dimensional-shape-models-on-data-from-the-osteoarthritis-initiative
#19
B Dube, M A Bowes, S R Kingsbury, E M A Hensor, S Muzumdar, P G Conaghan
OBJECTIVES: Meniscal pathology is integral to knee osteoarthritis (OA) and its progression; it provides a progression biomarker and a potential treatment target. Magnetic resonance imaging (MRI) demonstrates large heterogeneity in meniscal damage; this structural complexity means measurement is difficult. The aim of this study was to apply novel 3D image analysis to determine which meniscal pathologies demonstrated most change during OA progression. METHODS: Knee images were selected from the progression cohort of the Osteoarthritis Initiative choosing participants with risk factors for medial OA progression...
October 17, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29047243/three-dimensional-fast-spin-echo-imaging-without-fat-suppression-of-the-knee-diagnostic-accuracy-comparison-to-fat-suppressed-imaging-on-1-5t-mri
#20
Hee Woo Cho, Jin Suck Suh, Jin Oh Park, Hyoung Sik Kim, Soo Yoon Chung, Young Han Lee, Seok Hahn
PURPOSE: To evaluate the diagnostic performance of three-dimensional fast spin-echo (3D FSE-Cube) without fat suppression (NFS) for detecting knee lesions, using comparison to 3D FSE-Cube with fat suppression (FS). MATERIALS AND METHODS: One hundred twenty-four patients who underwent 1.5T knee magnetic resonance imaging (MRI) scans and 25 subsequent arthroscopic surgeries were retrospectively reviewed. Using arthroscopic results and two-dimensional images as reference standards, diagnostic performances of 3D FSE-Cube-NFS and FS imaging about lesions of ligament, meniscus, subchondral bone marrow edema (BME), and cartilage were compared...
November 2017: Yonsei Medical Journal
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