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Medial meniscus

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https://www.readbyqxmd.com/read/29789912/meniscal-pathologies-on-mri-correlate-with-increased-bone-tracer-uptake-in-spect-ct
#1
Jan Rechsteiner, Michael T Hirschmann, Milos Dordevic, Anna L Falkowski, Enrique A Testa, Felix Amsler, Anna Hirschmann
OBJECTIVES: To assess the relationship of subchondral bone tracer uptake (BTU) on SPECT/CT and meniscal pathologies on MRI in patients with painful knees. METHODS: Twenty-five patients who had MRI and SPECT/CT within 3 months without knee surgery or grade ≥3 cartilage lesions were prospectively included. Maximum values of each subchondral femorotibial area were quantified and a ratio was calculated in relation to a femoral shaft reference region, which represented the BTU background activity...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29781506/articular-cartilage-protection-in-ctsk-mice-is-associated-with-cellular-and-molecular-changes-in-subchondral-bone-and-cartilage-matrix
#2
Fabiana N Soki, Ryu Yoshida, David N Paglia, Le T Duong, Marc F Hansen, Hicham Drissi
Osteoarthritis (OA) is a degenerative disease and a major cause of chronic disability in aging individuals. Cathepsin K (CatK), encoded by the Ctsk gene, has been implicated in the pathogenesis of pycnodysostosis and osteoporosis. The use of a selective inhibitor of CatK was recently shown to delay OA progression in rabbits. However, the cellular mechanisms underlying these protective effects remain unexplored. We examined articular cartilage maintenance and joint bone remodeling using Ctsk null mice (Ctsk-/- ) which underwent destabilization of the medial meniscus (DMM)...
May 21, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29770332/incidence-and-extent-of-graft-extrusion-following-meniscus-allograft-transplantation
#3
REVIEW
Dae-Hee Lee
Background: The incidence and extent of graft extrusion after meniscus allograft transplantation (MAT) may differ in patients undergoing medial and lateral meniscus transplantation due to the use of different surgical techniques. This meta-analysis was therefore designed to quantify the extent and incidence of graft extrusion after meniscus allograft transplantation. Methods: Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, all studies reporting absolute extrusion, relative percentage of extrusion (RPE), or frequency of major extrusions (>3 mm) on magnetic resonance imaging in patients undergoing medial or lateral MAT were included...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29754495/evaluation-of-anterior-intermeniscal-ligament-in-discoid-lateral-meniscus-cases-and-presenting-the-accompanying-meniscal-pathologies-with-mri
#4
Ali Koç, Turgut Tursem Tokmak, Özgür Karabıyık, Gamze Türk
Background Although several studies were conducted to put forth the biomechanical function of anterior intermeniscal ligament (AIML) on the stability of meniscal structures, there are few data on the etiology of the early degeneration of discoid type compared to the normal shaped ones. Purpose To determine the AIML subtypes and accompanying meniscal pathologies in discoid lateral menisci (DLM) on knee MRI exams. Material and Methods Knee MRI exams of 171 individuals with DLM were reviewed. DLMs and AIMLs were typed according to Watanabe's classification and Nelson-Laprade classification, respectively...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29752501/it-is-safe-and-effective-to-use-all-inside-meniscal-repair-devices-for-posteromedial-meniscal-ramp-lesions
#5
Giles Heilpern, Jo Stephen, Simon Ball, Andrew Amis, Andy Williams
PURPOSE: Recently, it has been recognized that meniscocapsular ('ramp') lesions of the posterior one-third of the medial meniscus frequently occur during injuries causing ACL rupture, and that these lesions are easily missed at arthroscopy. Furthermore, it is clear that these lesions are biomechanically significant, adding to the deficits caused by ACL rupture, and that their repair can reverse this. The efficacy of an all inside repair technique has been questioned by some authors and by those who advocate a suture shuttle technique via an accessory posteromedial portal...
May 12, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29752059/risk-factors-for-abnormal-anteroposterior-knee-laxity-after-primary-anterior-cruciate-ligament-reconstruction
#6
Riccardo Cristiani, Magnus Forssblad, Björn Engström, Gunnar Edman, Anders Stålman
PURPOSE: To identify preoperative and intraoperative factors associated with abnormal anterior knee laxity after primary anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 5,462 patients who underwent primary ACL reconstruction at our institution from January 2000 to October 2015, with no associated ligament injuries, were included. Demographic data, information regarding graft used, concomitant meniscal surgery, and instrumented laxity were reviewed...
May 8, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29750304/intraperitoneal-injection-of-thalidomide-alleviates-early-osteoarthritis-development-by-suppressing-vascular-endothelial-growth-factor-expression-in-mice
#7
Jia Lin Song, De Long Li, Hang Fang, Dao Zhang Cai
Vascular endothelial growth factor (VEGF) is expressed in articular cartilage and increases in expression levels have been associated with the progression of osteoarthritis (OA). Thalidomide is a drug that has been reported to inhibit angiogenesis and reduce VEGF production by downregulating VEGF expression. The objective of the present study was to determine whether intraperitoneal administration of thalidomide may attenuate early OA development in mice. Male C57BL/6 mice (10‑weeks‑old) were randomly assigned into the destabilization of the medial meniscus (Dmm) with thalidomide treatment (Dmm+Th), Dmm and Sham groups equally...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29747385/mithramycin-a-alleviates-osteoarthritic-cartilage-destruction-by-inhibiting-hif-2%C3%AE-expression
#8
Moon-Chang Choi, Woo Hee Choi
Osteoarthritis (OA) is the most common and increasing joint disease worldwide. Current treatment for OA is limited to control of symptoms. The purpose of this study was to determine the effect of specificity protein 1 (SP1) inhibitor Mithramycin A (MitA) on chondrocyte catabolism and OA pathogenesis and to explore the underlying molecular mechanisms involving SP1 and other key factors that are critical for OA. Here, we show that MitA markedly inhibited expressions of matrix-degrading enzymes induced by pro-inflammatory cytokine interleukin-1β (IL-1β) in mouse primary chondrocytes...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29744983/expression-of-p16-ink-4a-is-a-biomarker-of-chondrocyte-aging-but-does-not-cause-osteoarthritis
#9
Brian O Diekman, Garrett A Sessions, John A Collins, Anne K Knecht, Susan L Strum, Natalia K Mitin, Cathy S Carlson, Richard F Loeser, Norman E Sharpless
Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro-inflammatory molecules known as the senescence-associated secretory phenotype (SASP). The senescence biomarker p16INK 4a is a potent inhibitor of the cell cycle but is not essential for SASP production. Thus, it is unclear whether p16INK 4a identifies senescence in hyporeplicative cells such as articular chondrocytes and whether p16INK 4a contributes to pathologic characteristics of cartilage aging...
May 9, 2018: Aging Cell
https://www.readbyqxmd.com/read/29741957/effects-of-proud-large-osteochondral-plugs-on-contact-forces-and-knee-kinematics-a-robotic-study
#10
Peter Z Du, Keith L Markolf, Daniel V Boguszewski, Kent T Yamaguchi, Christopher J Lama, David R McAllister, Kristofer J Jones
BACKGROUND: Osteochondral allograft (OCA) transplantation is used to treat large focal femoral condylar articular cartilage defects. A proud plug could affect graft survival by altering contact forces (CFs) and knee kinematics. HYPOTHESIS: A proud OCA plug will significantly increase CF and significantly alter knee kinematics throughout controlled knee flexion. STUDY DESIGN: Controlled laboratory study. METHODS: Human cadaver knees had miniature load cells, each with a 20-mm-diameter cylinder of native bone/cartilage attached at its exact anatomic position, installed in both femoral condyles at standardized locations representative of clinical defects...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29741400/anterolateral-ligament-reconstruction-protects-the-repaired-medial-meniscus-a-comparative-study-of-383-anterior-cruciate-ligament-reconstructions-from-the-santi-study-group-with-a-minimum-follow-up-of-2-years
#11
Bertrand Sonnery-Cottet, Adnan Saithna, William G Blakeney, Herve Ouanezar, Amrut Borade, Matt Daggett, Mathieu Thaunat, Jean-Marie Fayard, Jean Romain Delaloye
BACKGROUND: The prevalence of osteoarthritis after successful meniscal repair is significantly less than that after failed meniscal repair. PURPOSE: To determine whether the addition of anterolateral ligament reconstruction (ALLR) confers a protective effect on medial meniscal repair performed at the time of anterior cruciate ligament reconstruction (ACLR). STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Retrospective analysis of prospectively collected data was performed to include all patients who had undergone primary ACLR with concomitant posterior horn medial meniscal repair through a posteromedial portal between January 2013 and August 2015...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29738601/the-meniscal-comma-sign-characterization-and-treatment-of-a-displaced-fragment-in-the-meniscotibial-recess
#12
Hytham S Salem, Aaron H Carter, Weilong J Shi, Fotios P Tjoumakaris, Steven B Cohen, Adam C Zoga, Kevin B Freedman
Displaced parrot beak flap tears in the meniscotibial recess are complex tears of the meniscus that begin as central radial tears and progressively extend toward the periphery, creating a detached fragment. These tears have not been described in the literature, but the authors have described them as the "meniscal comma sign" based on their appearance on magnetic resonance imaging. Displaced fragments are clinically significant because of the pain and mechanical symptoms they can cause as a result of tenting of the deep medial collateral ligament...
May 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29729766/editorial-commentary-medial-meniscal-ramp-lesions-lessons-learned-from-the-past-in-the-pursuit-of-evidence
#13
EDITORIAL
Romain Seil
Thirty-five years after their initial description, ramp lesions of the medial meniscus in anterior cruciate ligament (ACL)-deficient knees are slowly being rediscovered. Routinely repaired in open ACL and peripheral reconstructions before the era of arthroscopic ACL reconstruction, ramp lesions have been largely ignored in the last 2 decades. Following the growing number of studies analyzing the causes of residual laxity after ACL reconstructions over the last decade, ramp lesions are increasingly being implicated, and thus investigated, but remain poorly understood...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29729763/editorial-commentary-anteromedial-meniscofemoral-ligament-of-the-anterior-horn-of-the-medial-meniscus-i-ve-never-seen-that-before-but-has-it-seen-me
#14
EDITORIAL
Eric W Nelson
Although there is frequently an element of variability found in human anatomy, we tend to think of anatomic structures as following the pattern in which we, as surgeons, most frequently encounter them. Though it is possible that a variant pattern of a commonly encountered anatomic structure has "never been seen" by us as surgeons, the constant process of learning sometimes leads us to ask ourselves whether we have truly never encountered such a structure or condition before or whether we simply did not recognize it when it "saw us...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29718873/the-imaging-features-of-the-meniscal-roots-on-isotropic-3d-mri-in-young-asymptomatic-volunteers
#15
Ping Wang, Cheng-Zhou Zhang, Di Zhang, Quan-Yuan Liu, Xiao-Fei Zhong, Zhi-Jie Yin, Bin Wang
BACKGROUND: This study aimed to describe clearly the normal imaging features of the meniscal roots on the magnetic resonance imaging (MRI) with a 3-dimensional (3D) proton density-weighted (PDW) sequence at 3T. METHODS: A total of 60 knees of 31 young asymptomatic volunteers were examined using a 3D MRI. The insertion patterns, constitution patterns, and MR signals of the meniscal roots were recorded. RESULTS: The anterior root of the medial meniscus (ARMM), the anterior root of the lateral meniscus (ARLM), and the posterior root of the medial meniscus (PRMM) had 1 insertion site, whereas the posterior root of the lateral meniscus (PRLM) can be divided into major and minor insertion sites...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29717217/progression-of-post-traumatic-osteoarthritis-in-rat-meniscectomy-models-comprehensive-monitoring-using-mri
#16
Tonima S Ali, Indira Prasadam, Yin Xiao, Konstantin I Momot
Knee injury often triggers post-traumatic osteoarthritis (PTOA) that affects articular cartilage (AC), subchondral bone, meniscus and the synovial membrane. The available treatments for PTOA are largely ineffective due to late diagnosis past the "treatment window". This study aimed to develop a detailed understanding of the time line of the progression of PTOA in murine models through longitudinal observation of the femorotibial joint from the onset of the disease to the advanced stage. Quantitative magnetic resonance microimaging (µMRI) and histology were used to evaluate PTOA-associated changes in the knee joints of rats subjected to knee meniscectomy...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29705348/proteoglycans-contribute-locally-to-swelling-but-globally-to-compressive-mechanics-in-intact-cervine-medial-meniscus
#17
Arthur J Michalek, Laurel Kuxhaus, Daniel Jaremczuk, Nicole L Zaino
Loss of charged proteoglycans in the knee meniscus, which aid in the support of compressive loads by entraining water, is an effect of degeneration and is often associated with osteoarthritis. In healthy menisci, proteoglycan content is highest in the inner white zone and decreases towards the peripheral red zone. We hypothesized that loss of proteoglycans would reduce both osmotic swelling and compressive stiffness, spatially localized to the avascular white zone of the meniscus. This hypothesis was tested by targeted enzymatic digestion of proteoglycans using hyaluronidase in intact cervine medial menisci...
April 24, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29691435/elf3-contributes-to-cartilage-degradation-in-vivo-in-a-surgical-model-of-post-traumatic-osteoarthritis
#18
Elisabeth B Wondimu, Kirsty L Culley, Justin Quinn, Jun Chang, Cecilia L Dragomir, Darren A Plumb, Mary B Goldring, Miguel Otero
The E-74 like factor 3 (ELF3) is a transcription factor induced by inflammatory factors in various cell types, including chondrocytes. ELF3 levels are elevated in human cartilage from patients with osteoarthritis (OA), and ELF3 contributes to the IL-1β-induced expression of genes encoding Mmp13, Nos2, and Ptgs2/Cox2 in chondrocytes in vitro. Here, we investigated the contribution of ELF3 to cartilage degradation in vivo, using a mouse model of OA. To this end, we generated mouse strains with cartilage-specific Elf3 knockout (Col2Cre:Elf3f/f ) and Comp-driven Tet-off-inducible Elf3 overexpression (TRE-Elf3:Comp-tTA)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29687871/cell-therapy-of-a-knee-osteoarthritis-rat-model-using-precartilaginous-stem-cells
#19
M-P Fan, M Si, B-J Li, G-H Hu, Y Hou, W Yang, L Liu, B Tang, L Nie
OBJECTIVE: To explore the effect and mechanism of precartilaginous stem cells (PSCs) engraftment-inducing tissue repair in a knee osteoarthritis (OA) rat model. MATERIALS AND METHODS: Knee osteoarthritis (OA) model was constructed in Sprague Dawley (SD) rats by partial removal of the medial meniscus of the right knee. PSCs were engrafted by injecting precartilaginous stem cells (PSCs) into the right knee cavity. At 4 and 8 weeks after model construction, the serum levels of interleukine (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 were assessed using enzyme-linked immunosorbent assay (ELISA)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29686971/snapping-elbow-a-guide-to-diagnosis-and-treatment
#20
Jonathan Jetsmark Bjerre, Finn Elkjær Johannsen, Martin Rathcke, Michael Rindom Krogsgaard
AIM: To develop practical guidelines for diagnosis and treatment of the painful snapping elbow syndrome (SE). METHODS: Clinical studies were searched in the databases PubMed and Scopus for the phrases "SE", "snapping triceps", "snapping ulnar nerve" and "snapping annular ligament". A total of 36 relevant studies were identified. From these we extracted information about number of patients, diagnostic methods, patho-anatomical findings, treatments and outcomes...
April 18, 2018: World Journal of Orthopedics
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