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https://www.readbyqxmd.com/read/28070626/nuclear-receptors-regulate-lipid-metabolism-and-oxidative-stress-markers-in-chondrocytes
#1
Anusha Ratneswaran, Margaret Man-Ger Sun, Holly Dupuis, Cynthia Sawyez, Nica Borradaile, Frank Beier
: Joint homeostasis failure can result in osteoarthritis (OA). Currently, there are no treatments to alter disease progression in OA, but targeting early changes in cellular behavior has great potential. Recent data show that nuclear receptors contribute to the pathogenesis of OA and could be viable therapeutic targets, but their molecular mechanisms in cartilage are incompletely understood. This study examines global changes in gene expression after treatment with agonists for four nuclear receptor implicated in OA (LXR, PPARδ, PPARγ, and RXR)...
January 9, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28065381/the-contribution-of-3d-quantitative-meniscal-and-cartilage-measures-to-variation-in-normal-radiographic-joint-space-width-data-from-the-osteoarthritis-initiative-healthy-reference-cohort
#2
Melanie Roth, Wolfgang Wirth, Katja Emmanuel, Adam G Culvenor, Felix Eckstein
OBJECTIVE: To explore to what extent three-dimensional measures of the meniscus and femorotibial cartilage explain the variation in medial and lateral femorotibial radiographic joint space width (JSW), in healthy men and women. METHODS: The right knees of 87 Osteoarthritis Initiative healthy reference participants (no symptoms, radiographic signs or risk factors of osteoarthritis; 37 men, 50 women; age 55.0±7.6; BMI 24.4±3.1) were assessed. Quantitative measures of subregional femorotibial cartilage thickness and meniscal position and morphology were computed from segmented magnetic resonance images...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28060534/is-it-necessary-to-repair-stable-ramp-lesions-of-the-medial-meniscus-during-anterior-cruciate-ligament-reconstruction
#3
Xin Liu, Hui Zhang, Hua Feng, Lei Hong, Xue-Song Wang, Guan-Yang Song
BACKGROUND: A special type of meniscal lesion involving the peripheral attachment of the posterior horn of the medial meniscus (PHMM), termed a "ramp lesion," is commonly associated with an anterior cruciate ligament (ACL) injury. However, its treatment is still controversial. Recently, stable ramp lesions treated with abrasion and trephination alone have been shown to have good clinical outcomes after ACL reconstruction. HYPOTHESIS: Stable ramp lesions treated with abrasion and trephination alone during ACL reconstruction will result in similar clinical outcomes compared with those treated with surgical repair...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28057910/arthroscopic-detection-of-medial-meniscal-injury-in-small-breed-dogs-with-the-use-of-a-joint-distractor
#4
Joo-Ho Kim, Su-Young Heo, Hae-Beom Lee
The goal of the present study was to evaluate the diagnostic value of a joint distractor in arthroscopy in small-breed dogs. Sixty stifle joints, which were collected from thirty cadavers, were used in this study. To simulate different injuries, no medial meniscal tear, a full-thickness vertical longitudinal tear, a partial-thickness vertical longitudinal tear, full- and partial-thickness vertical longitudinal tears, or a peripheral detachment were made on the caudal horn of the medial meniscus of each stifle joint along with cranial cruciate ligament (CrCL) rupture...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28057326/meniscus-morphology-does-tear-type-matter-a-narrative-review-with-focus-on-relevance-for-osteoarthritis-research
#5
REVIEW
Mohamed Jarraya, Frank W Roemer, Martin Englund, Michel D Crema, Heather I Gale, Daichi Hayashi, Jeffrey N Katz, Ali Guermazi
OBJECTIVE: To give a narrative overview of meniscal tears with a radiologic emphasis on the morphologic type, technical considerations, and on the relevance of the type of meniscal tear in the context of osteoarthritis (OA) research. DESIGN: Total 20 years of the PubMed database were searched for epidemiological, radiological, arthroscopic and biomechanical reports, and review articles focusing on meniscal tears in middle-aged and older individuals, in the setting of OA...
November 24, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28034603/useful-ultrasonographic-evaluation-of-the-medial-meniscus-as-a-feature-predicting-the-onset-of-radiographic-knee-osteoarthritis
#6
Taiki Murakami, Makoto Enokida, Kei Kawaguchi, Ryoji Otsuki, Hideki Nagashima
OBJECTIVE: Medial radial displacement (MRD) of the medial meniscus is a feature proving a dysfunction in the medial meniscus in osteoarthritis (OA) of the knee. MRD was measured in radiographic pre-OA knee and early osteoarthritis of the knee (early-OA) longitudinally using ultrasound (US) to investigate the characteristics involved in the onset and progression of OA. METHODS: Fifty-five patients with pain on the medial side of the knee participated in the present study...
December 27, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28028568/arthroscopic-all-inside-ramp-lesion-repair-using-the-posterolateral-transseptal-portal-view
#7
Sohrab Keyhani, Jin Hwan Ahn, René Verdonk, Mehran Soleymanha, Mohammadreza Abbasian
PURPOSE: The purpose of this study was to evaluate and describe the clinical results and outcomes of a novel method for all-inside suture repair of medial meniscus ramp lesions through posteromedial and posterolateral transseptal portals during anterior cruciate ligament (ACL) reconstruction. Further, this investigation compared the posterolateral view to the notch view for diagnosis and repair. METHODS: Between 2011 and 2014, 166 patients had ramp lesions concomitantly with ACL injury; 128 patients (107 men and 21 women) were enrolled in the study after qualification...
December 27, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28018086/leukocyte-poor-platelet-rich-plasma-to-treat-degenerative-meniscal-tear-a-case-report
#8
J P Betancourt, W D Murrell
A traumatic and/or degenerative meniscus lesion is thought to be a clinical manifestation of early-onset osteoarthritis (OA), which is a chronic progressive condition that can cause substantial pain and disability. Platelet-rich plasma (PRP) is an emerging treatment option that has been reported to improve healing. Here, we present a case of a 29-year-old woman, with left anterior and medial knee pain, without history of trauma or injury. The patient was managed with leukocyte-poor PRP injections derived from her peripheral blood with high concentrations of platelets, platelet-derived growth factors, and bioactive proteins, with a total follow-up of 30 months...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28012003/effect-of-radial-meniscal-tear-on-in-situ-forces-of-meniscus-and-tibiofemoral-relationship
#9
Yuta Tachibana, Tatsuo Mae, Hiromichi Fujie, Konsei Shino, Tomoki Ohori, Hideki Yoshikawa, Ken Nakata
PURPOSE: To clarify the effect of the radial tear of the lateral meniscus on the in situ meniscus force and the tibiofemoral relationship under axial loads and valgus torques. METHODS: Ten intact porcine knees were settled to a 6-degree of freedom robotic system, while the force and 3-dimensional path of the knees were recorded via Universal Force Sensor (UFS) during 3 cycles of 250-N axial load and 5-Nm valgus torque at 15°, 30°, 45°, and 60° of knee flexion...
December 23, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28005131/strain-dependent-glucose-partitioning-in-meniscus-fibrocartilage
#10
Kelsey L Kleinhans, Alicia Jackson
A nearly avascular tissue, the knee meniscus relies on diffusive transport for nutritional supply to cells. Nutrient transport depends on solute partitioning in the tissue, which governs the amount of nutrients that can enter a tissue. The purpose of the present study was to investigate the effects of mechanical strain, tissue region, and tissue composition on the partition coefficient of glucose in meniscus fibrocartilage. A simple partitioning experiment was employed to measure glucose partitioning in porcine meniscus tissues from two regions (horn and central), from both meniscal components (medial and lateral), and at three levels of compression (0%, 10%, and 20%)...
December 22, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28005104/potential-operating-room-fire-hazard-of-bone-cement
#11
Udai S Sibia, Kevin Connors, Sarah Dyckman, Hamid R Zahiri, Ivan George, Adrian E Park, James H MacDonald
Approximately 600 cases of operating room (OR) fires are reported annually. Despite extensive fire safety education and training, complete elimination of OR fires still has not been achieved. Each fire requires an ignition source, a fuel source, and an oxidizer. In this case report, we describe the potential fire hazard of bone cement in the OR. A total knee arthroplasty was performed with a standard medial parapatellar arthrotomy. Tourniquet control was used. After bone cement was applied to the prepared tibial surface, the surgeon used an electrocautery device to resect residual lateral meniscus tissue-and started a fire in the operative field...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27993462/complex-medial-meniscus-tears-are-associated-with-a-biconcave-medial-tibial-plateau
#12
F Alan Barber, Mark H Getelman, Kathy L Berry
PURPOSE: To determine whether an association exists between a biconcave medial tibial plateau and complex medial meniscus tears. METHODS: A consecutive series of stable knees undergoing arthroscopy were evaluated retrospectively with the use of preoperative magnetic resonance imaging (MRI), radiographs, and arthroscopy documented by intraoperative videos. Investigators independently performed blinded reviews of the MRI or videos. Based on the arthroscopy findings, medial tibial plateaus were classified as either biconcave or not biconcave...
December 16, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27987426/structure-function-relationships-of-human-meniscus
#13
Elvis K Danso, Joonas M T Oinas, Simo Saarakkala, Santtu Mikkonen, Juha Töyräs, Rami K Korhonen
Biomechanical properties of human meniscus have been shown to be site-specific. However, it is not known which meniscus constituents at different depths and locations contribute to biomechanical properties obtained from indentation testing. Therefore, we investigated the composition and structure of human meniscus in a site- and depth-dependent manner and their relationships with tissue site-specific biomechanical properties. Elastic and poroelastic properties were analyzed from experimental stress-relaxation and sinusoidal indentation measurements with fibril reinforced poroelastic finite element modeling...
December 3, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27986622/unique-spatiotemporal-and-dynamic-gait-compensations-in-the-rat-monoiodoacetate-injection-and-medial-meniscus-transection-models-of-knee-osteoarthritis
#14
B Y Jacobs, K Dunnigan, M Pires-Fernandes, K D Allen
OBJECTIVE: In rodent osteoarthritis (OA) models, behavioral changes are often subtle and require highly sensitive methods to detect these changes. Gait analysis is one assay that may provide sensitive, quantitative measurement of these behavioral changes. To increase detection sensitivity of gait assessments relative to spatiotemporal gait collection alone, we combined our spatiotemporal and dynamic gait collection systems. Using this combined system, gait was assessed in the rat medial meniscus transection (MMT) model and monoiodoacetate (MIA) injection model of knee OA...
December 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27984833/-injuries-during-equestrian-vaulting
#15
M Endruweit, J Dargel, J Siewe, I Becker, R Sobottke
Background: Vaulting is the least studied equestrian sports regarding the occurrence of injuries. As its sequences of motion do not compare to riding, vaulting must be assessed separately. Material and Methods: This retrospective, questionnaire-aided survey was aimed to gain insight into the overall frequency of injuries among equestrian vaulters. The second part of the study looked into the knee injuries that occurred. Survey forms were sent to 60 vaulting and equestrian clubs all over Germany, making for a response rate of 63 %...
December 2016: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/27965260/ccl2-ccr2-but-not-ccl5-ccr5-mediates-monocyte-recruitment-inflammation-and-cartilage-destruction-in-osteoarthritis
#16
Harini Raghu, Christin M Lepus, Qian Wang, Heidi H Wong, Nithya Lingampalli, Francesca Oliviero, Leonardo Punzi, Nicholas J Giori, Stuart B Goodman, Constance R Chu, Jeremy B Sokolove, William H Robinson
OBJECTIVES: While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis. METHODS: Ccl2-, Ccr2-, Ccl5- and Ccr5-deficient and control mice were subjected to destabilisation of medial meniscus surgery to induce OA...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27965139/physiological-exercise-loading-suppresses-post-traumatic-osteoarthritis-progression-via-an-increase-in-bone-morphogenetic-proteins-expression-in-an-experimental-rat-knee-model
#17
H Iijima, A Ito, M Nagai, J Tajino, S Yamaguchi, W Kiyan, A Nakahata, J Zhang, T Wang, T Aoyama, K Nishitani, H Kuroki
OBJECTIVE: To evaluate the dose-response relationship of exercise loading in the cartilage-subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. DESIGN: Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar rats, and sham surgery was performed on the contralateral knee. Four weeks after the surgery, the animals were subjected to moderate (12 m/min) or intense (21 m/min) treadmill exercises for 30 min/day, 5 days/week for 4 weeks...
December 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27956232/changes-in-contact-area-in-meniscus-horizontal-cleavage-tears-subjected-to-repair-and-resection
#18
Brandon S Beamer, Kempland C Walley, Stephen Okajima, Ohan S Manoukian, Miguel Perez-Viloria, Joseph P DeAngelis, Arun J Ramappa, Ara Nazarian
PURPOSE: To assess the changes in tibiofemoral contact pressure and contact area in human knees with a horizontal cleavage tear before and after treatment. METHODS: Ten human cadaveric knees were tested. Pressure sensors were placed under the medial meniscus and the knees were loaded at twice the body weight for 20 cycles at 0°, 10°, and 20° of flexion. Contact area and pressure were recorded for the intact meniscus, the meniscus with a horizontal cleavage tear, after meniscal repair, after partial meniscectomy (single leaflet), and after subtotal meniscectomy (double leaflet)...
December 9, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27956221/ethylene-glycol-and-glycerol-loading-and-unloading-in-porcine-meniscal-tissue
#19
Talal A Takroni, Hana Yu, Leila Laouar, Adetola B Adesida, Janet A W Elliott, Nadr M Jomha
The development of a long-term storage method for meniscus, a complex tissue of the knee prone to injury, would improve the procedure and outcomes of meniscus transplantation. Cryopreservation uses cryoprotective agents (CPAs) including ethylene glycol (EG) and glycerol to preserve a variety of live tissues, and understanding of the CPA permeation kinetics will be critical in designing a vitrification protocol for meniscus. The purpose of this preliminary study was to understand the loading and unloading behaviours of EG and glycerol in meniscus by observing their efflux...
December 9, 2016: Cryobiology
https://www.readbyqxmd.com/read/27941690/procyanidins-mitigate-osteoarthritis-pathogenesis-by-at-least-in-part-suppressing-vascular-endothelial-growth-factor-signaling
#20
Angela Wang, Daniel J Leong, Zhiyong He, Lin Xu, Lidi Liu, Sun Jin Kim, David M Hirsh, John A Hardin, Neil J Cobelli, Hui B Sun
Procyanidins are a family of plant metabolites that have been suggested to mitigate osteoarthritis pathogenesis in mice. However, the underlying mechanism is largely unknown. This study aimed to determine whether procyanidins mitigate traumatic injury-induced osteoarthritis (OA) disease progression, and whether procyanidins exert a chondroprotective effect by, at least in part, suppressing vascular endothelial growth factor signaling. Procyanidins (extracts from pine bark), orally administered to mice subjected to surgery for destabilization of the medial meniscus, significantly slowed OA disease progression...
December 9, 2016: International Journal of Molecular Sciences
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