keyword
MENU ▼
Read by QxMD icon Read
search

Medial meniscus

keyword
https://www.readbyqxmd.com/read/28197696/large-meniscus-extrusion-ratio-is-a-poor-prognostic-factor-of-conservative-treatment-for-medial-meniscus-posterior-root-tear
#1
Yoon-Ho Kwak, Sahnghoon Lee, Myung Chul Lee, Hyuk-Soo Han
PURPOSE: The purpose of this study was to find a prognostic factor of medial meniscus posterior root tear (MMPRT) for surgical decision making. METHODS: Eighty-eight patients who were diagnosed as acute or subacute MMPRT without severe degeneration of the meniscus were treated conservatively for 3 months. Fifty-seven patients with MMPRT showed good response to conservative treatment (group 1), while the remaining 31 patients who failed to conservative treatment (group 2) received arthroscopic meniscus repair...
February 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28190582/correlation-of-parameters-on-preoperative-ct-images-with-intra-articular-soft-tissue-injuries-in-acute-tibial-plateau-fractures-a-review-of-132-patients-receiving-arif
#2
Hao-Che Tang, I-Jung Chen, Yu-Cheng Yeh, Chun-Jui Weng, Shih-Sheng Chang, Alvin Chao-Yu Chen, Yi-Sheng Chan
INTRODUCTION: Tibial plateau fractures often occur in conjunction with soft-tissue injuries of knees. The hypothesis of this study is that parameters of CT imaging can predict intra-articular soft-tissue injuries. PATIENTS AND METHODS: Patients who underwent arthroscopically assisted reduction and internal fixation (ARIF) for acute tibial plateau fractures performed by a single orthopedic surgeon between 2005 and 2015 were included in this retrospective study. Patients with concomitant ipsilateral femoral fractures, who had received revision surgery or who had undergone index surgery more than 30days from the event were excluded...
January 30, 2017: Injury
https://www.readbyqxmd.com/read/28184957/partial-meniscectomy-provides-no-benefit-for-symptomatic-degenerative-medial-meniscus-posterior-root-tears
#3
Aaron J Krych, Nick R Johnson, Rohith Mohan, Diane L Dahm, Bruce A Levy, Michael J Stuart
PURPOSE: Medial meniscus posterior root tears (MMPRTs) are recognized as a source of pain and dysfunction, but treatment options remain a challenge. The purpose of the study was to determine (1) the efficacy of partial meniscectomy to treat MMPRTs compared to a matched group of non-operatively treated MMPRTs, and (2) risk factors for worse clinical and radiographic outcome. METHODS: This retrospective comparative study was performed to include patients with complete, isolated MMPRTs with documented clinical symptoms and were treated with arthroscopic partial meniscectomy (PMM) and a minimum 2-year follow-up...
February 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28181577/age-dependent-changes-in-the-articular-cartilage-and-subchondral-bone-of-c57bl-6-mice-after-surgical-destabilization-of-medial-meniscus
#4
Henry Huang, Jordan D Skelly, David C Ayers, Jie Song
Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are frequently performed on young adult mice only. This study investigates how age affects cartilage and subchondral bone changes in mouse joints following DMM. DMM was performed on male C57BL/6 mice at 4 months (4 M), 12 months (12 M) and 19+ months (19 M+) and on females at 12 M and 18 M+. Two months after surgery, operated and unoperated contralateral knees were harvested and evaluated using cartilage histology scores and μCT quantification of subchondral bone plate thickness and osteophyte formation...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169099/the-role-of-medial-meniscus-posterior-root-tear-and-proximal-tibial-morphology-in-the-development-of-spontaneous-osteonecrosis-and-osteoarthritis-of-the-knee
#5
Ryota Yamagami, Shuji Taketomi, Hiroshi Inui, Keitaro Tahara, Sakae Tanaka
BACKGROUND: Medial meniscus posterior root tear (MMPRT) has been reported to play a key role in the development of spontaneous osteonecrosis of the knee (SONK) and osteoarthritis (OA) of the knee. However, little is known about the differences in the development of SONK and OA after MMPRT. The purpose of this study was to investigate the factors contributing to the development of these conditions. METHODS: We evaluated the existence of MMPRT and the extent of medial meniscal extrusion in preoperative magnetic resonance images and proximal tibial morphology in radiographs of 45 patients with SONK and 104 patients with OA who underwent knee surgery...
February 3, 2017: Knee
https://www.readbyqxmd.com/read/28168658/plumbagin-prevents-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes-and-prevents-the-progression-of-osteoarthritis-in-mice
#6
Wenhao Zheng, Zhenyu Tao, Chunhui Chen, Chuanxu Zhang, Hui Zhang, Xiaozhou Ying, Hua Chen
Inflammation and inflammatory cytokines have been reported to play vital roles in the development of osteoarthritis (OA). Plumbagin, a quinonoid compound extracted from the roots of medicinal herbs of the Plumbago genus, has been reported to have anti-inflammatory effects. However, the anti-inflammatory effects of plumbagin on OA have not been reported. This study aimed to assess the effects of plumbagin on human OA chondrocytes and in a mouse model of OA induced by destabilization of the medial meniscus (DMM)...
February 7, 2017: Inflammation
https://www.readbyqxmd.com/read/28165497/wnt7a-inhibits-il-1%C3%AE-induced-catabolic-gene-expression-and-prevents-articular-cartilage-damage-in-experimental-osteoarthritis
#7
Averi L Gibson, Carrie K Hui Mingalone, Andrea T Foote, Tomoya Uchimura, Ming Zhang, Li Zeng
Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known. In this study, we found a unique inverse correlation between Wnt7a gene expression and that of MMP and IL-1β in individual human OA cartilage specimens. Upon ectopic expression in primary human articular chondrocytes, Wnt7a inhibited IL-1β-induced MMP and iNOS gene expression. Western blot analysis indicated that Wnt7a induced both canonical Wnt signaling and NFAT and Akt non-canonical signaling...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164061/arthroscopic-meniscectomy-and-meniscoplasty-for-a-torn-discoid-medial-meniscus-case-report-surgical-technique-and-literature-review
#8
Gokhale Nikhil Abhay, Samant Ashwin, Shahane Sunil, Kapopara Hardik
INTRODUCTION: Normal menisci of the knee are semilunar structures. Sometimes, a meniscus may be found to be thickened and disc like and is called a discoid meniscus. Such a discoid variant is usually found in the lateral meniscus. Its occurrence in the medial meniscus is extremely rare. CASE REPORT: We report a case of an 18-year-old female, who presented to us with knee pain and was found to have a discoid medial meniscus with a tear. We operated on her arthroscopically and performed meniscectomy and meniscoplasty...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28164045/ipsilateral-medial-and-lateral-discoid-meniscus-with-medial-meniscus-tear
#9
Kengo Shimozaki, Junsuke Nakase, Yoshinori Ohashi, Hitoaki Numata, Takeshi Oshima, Yasushi Takata, Hiroyuki Tsuchiya
INTRODUCTION: Discoid meniscus is a well-documented knee pathology, and there are many cases of medial or lateral discoid meniscus reported in the literature. However, ipsilateral concurrent medial and lateral discoid meniscus is very rare, and only a few cases have been reported. Herein, we report a case of concurrent medial and lateral discoid meniscus. CASE REPORT: A 27-year-old Japanese man complained of pain on medial joint space in his right knee that was diagnosed as a complete medial and lateral discoid meniscus...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28160013/high-tibial-osteotomy-accelerates-lateral-compartment-osteoarthritis-in-discoid-meniscus-patients
#10
Jatin Prakash, Eun-Kyoo Song, Hong An Lim, Young Joo Shin, Cheng Jin, Jong-Keun Seon
PURPOSE: The valgus high tibial osteotomy (HTO) in patients with medial osteoarthritis and discoid lateral meniscus can result in increased load on the lateral compartment and hence a higher chances of tear. This may accelerate the progression of osteoarthritis on lateral compartment. We, therefore, carried out the case control study with a hypothesis that an HTO would accelerate the progression of osteoarthritis (OA) on lateral compartment in patients with complete discoid meniscus. METHODS: The records of all patients with open wedge HTO from 2008 to 2012 were evaluated for complete lateral discoid meniscus...
February 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28142351/epidemiology-of-surgically-managed-anterior-cruciate-ligament-ruptures-in-a-sports-surgery-practice
#11
Andrew Arjun Sayampanathan, Bryan Koh Thean Howe, Hamid Rahmatullah Bin Abd Razak, Chong Hwei Chi, Andrew Hwee Chye Tan
INTRODUCTION: Anterior cruciate ligament (ACL) tears are common knee injuries, especially among sportsmen and sportswomen. The aim of this study is to better understand the epidemiology of surgically managed ACL tears sustained in our institution. METHODS: All patients who underwent arthroscopic ACL reconstruction by the senior author of this article in Singapore from 2008 to 2013 were studied. Patients who were diagnosed clinically and/or radiologically to have a complete tear of the ACL and subsequently underwent arthroscopic ACL reconstruction were included...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28139355/intra-articular-delivery-of-antago-mir-483-5p-inhibits-osteoarthritis-by-modulating-matrilin-3-and-tissue-inhibitor-of-metalloproteinase-2
#12
Hua Wang, Haiyan Zhang, Qiuyi Sun, Yun Wang, Jun Yang, Jincheng Yang, Tao Zhang, Shenqiu Luo, Liping Wang, Yu Jiang, Chun Zeng, Daozhang Cai, Xiaochun Bai
MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA) pathogenesis. In our study, a real-time PCR assay revealed that miR-483-5p was upregulated in articular cartilage from OA patients and experimental OA mice induced by destabilization of the medial meniscus compared to their controls. Overexpression of miR-483-5p by intra-articular injection of lentivirus LV3-miR-483-5p significantly enhanced the severity of experimental OA. Consequently, we synthesized antago-miR-483-5p to silence the endogenous miR-483-5p and delivered it intra-articularly, which revealed that antago-miR-483-5p delayed the progression of experimental OA...
January 27, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28139016/a-human-blood-based-anti-inflammatory-solution-inhibits-osteoarthritis-progression-in-a-meniscal-tear-rat-study
#13
William King, Alison Bendele, Taylor Marohl, Jennifer Woodell-May
Current osteoarthritis (OA) research searches for treatments that modify the course of disease progression. Autologous Protein Solution (APS) is derived from whole blood and is a unique autologous therapy that contains high concentrations of white blood cells, platelets, and concentrated plasma, providing cytokines that can target the underlying mechanisms of disease progression. The APS Kit is currently under investigation for clinical use in the USA (NCT02262364). The aim of this study was to determine if APS has disease-modifying properties in the well-characterized rat meniscal tear-induced model of OA...
January 31, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28137664/comparing-intra-articular-ctxii-levels-assessed-via-magnetic-capture-or-lavage-in-a-rat-knee-osteoarthritis-model
#14
E G Yarmola, Y Y Shah, H E Kloefkorn, J Dobson, K D Allen
OBJECTIVE: Parallel measures of osteoarthritis (OA) pathogenesis across species can help researchers evaluate OA models relative to the human condition. Toward this need, our group recently developed a magnetic nanoparticle-based technology, termed magnetic capture, to analyze biomarkers within a rat knee. The objectives of this study were two-fold: (1) directly compare magnetic capture to lavage, and (2) assess c-telopeptide of collagen type II (CTXII) levels in the rat medial meniscus transection (MMT) model of knee OA...
January 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28131784/attenuation-of-subchondral-bone-abnormal-changes-in-osteoarthritis-by-inhibition-of-sdf-1-signaling
#15
Y Chen, S Lin, Y Sun, J Guo, Y Lu, C W Suen, J Zhang, Z Zha, K W Ho, X Pan, G Li
BACKGROUND: Current conservative treatments for osteoarthritis (OA) are largely symptoms control therapies. Further understanding on the pathological mechanisms of OA is crucial for new pharmacological intervention. OBJECTIVE: In this study, we investigated the role of Stromal cell-derived factor-1(SDF-1) in regulating subchondral bone changes during the progression of OA. METHODS: Clinical samples of different stages of OA severity were analyzed by histology staining, micro-CT, enzyme-linked immunosorbent assay (ELISA) and western blotting, to compare SDF-1 level in subchondral bone...
January 25, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28129516/intra-articular-recombinant-human-proteoglycan-4-mitigates-cartilage-damage-after-destabilization-of-the-medial-meniscus-in-the-yucatan-minipig
#16
Kimberly A Waller, Kaitlyn E Chin, Gregory D Jay, Ling X Zhang, Erin Teeple, Scott McAllister, Gary J Badger, Tannin A Schmidt, Braden C Fleming
BACKGROUND: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary lubrication. PRG4 has been shown previously to be down-regulated after traumatic joint injury such as a meniscal tear. Preliminary evidence suggests that intra-articular injection of PRG4 after injury will reduce cartilage damage in rat models of surgically induced posttraumatic osteoarthritis. OBJECTIVE: To determine the efficacy of intra-articular injection of full-length recombinant human lubricin (rhPRG4) for reducing cartilage damage after medial meniscal destabilization (DMM) in a preclinical large animal model...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28128866/cyclin-dependent-kinase-inhibitor-1-deficient-mice-are-susceptible-to-osteoarthritis-associated-with-enhanced-inflammation
#17
Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda
Osteoarthritis (OA) is a multifactorial disease, and recent data suggested that cell cycle-related proteins play a role in OA pathology. Cyclin-dependent kinase (CDK) inhibitor 1 (p21) regulates activation of other CDKs, and recently, we reported that p21 deficiency induced susceptibility to OA induced by destabilization of the medial meniscus (DMM) surgery through STAT3-signaling activation. However, the mechanisms associated with why p21 deficiency led to susceptibility to OA by the STAT3 pathway remain unknown...
January 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28124287/biomechanical-testing-of-transcapsular-meniscal-repair
#18
Ryo Iuchi, Tatsuo Mae, Konsei Shino, Tomohiko Matsuo, Hideki Yoshikawa, Ken Nakata
BACKGROUND: All of previous biomechanical studies on meniscal repair have examined the meniscus itself without synovial membrane and capsule, although in the clinical setting, the meniscal repair is generally performed including capsule. Therefore, biomechanical properties of transcapsular meniscal repair are unclear. Thus, this study aimed to clarify the biomechanical properties of transcapsular meniscal repair. METHODS: In 70 porcine femur-medial meniscus-tibia complexes with capsules, longitudinal meniscal tears were repaired using different suture techniques (inside-out or all-inside technique), suture methods (vertical or horizontal methods), and numbers of sutures (single or double)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28120109/effect-of-inhibiting-mmp13-and-adamts5-by-intra-articular-injection-of-small-interfering-rna-in-a-surgically-induced-osteoarthritis-model-of-mice
#19
Hiroko Hoshi, Ryuichiro Akagi, Satoshi Yamaguchi, Yuta Muramatsu, Yorikazu Akatsu, Yohei Yamamoto, Toshihide Sasaki, Kazuhisa Takahashi, Takahisa Sasho
Matrix metalloproteinase 13 (MMP13) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) are thought to play critical roles in cartilage degradation at the early phase of osteoarthritis (OA). The aim of this study is to examine the effect of chemically modified Mmp13 or Adamts5 small interfering RNA (siRNA), alone or in combination, in a mouse OA model. OA pathology was surgically induced in 9-week-old male C57/BL6 mice (n = 64) via destabilization of the medial meniscus (DMM)...
January 24, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28116255/post-traumatic-medial-meniscal-cyst-in-young-a-case-report
#20
Prafulla Herode, Abhijeet Shroff, Vishal Mandlewala, Amit Chaudhary
INTRODUCTION: Meniscal cysts are rare, in that cysts of lateral meniscus are 3 times to 10 times more common than those of medial meniscus. Etiology of meniscal cysts includes trauma which results in contusion and haemorrage within the substance of meniscus leading to mucoid degeneration. Degeneration with age results in local necrosis and mucoid degeneration into a cyst, developmental inclusion of synovial cells within the substance of the meniscus and often are a result of extrusion of synovial fluid through a tear of the meniscus, resulting in a one-way valve effect of the tear...
July 2016: Journal of Orthopaedic Case Reports
keyword
keyword
26938
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"