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Medial meniscus

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https://www.readbyqxmd.com/read/27911285/the-relation-between-chondromalacia-patella-and-meniscal-tear-and-the-sulcus-angle-trochlear-depth-ratio-as-a-powerful-predictor
#1
Hatice Resorlu, Coskun Zateri, Gurdal Nusran, Ferdi Goksel, Nilufer Aylanc
PURPOSE: To investigate the relation between chondromalacia patella and the sulcus angle/trochlear depth ratio as a marker of trochlear morphology. In addition, we also planned to show the relationship between meniscus damage, subcutaneous adipose tissue thickness as a marker of obesity, patellar tilt angle and chondromalacia patella. METHODS: Patients with trauma, rheumatologic disease, a history of knee surgery and patellar variations such as patella alba and patella baja were excluded...
November 25, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27904597/where-does-magnetic-resonance-imaging-stand-in-the-diagnosis-of-knee-injuries
#2
Shirvan Rastegar, Mahdi Motififard, Amin Nemati, Naeime-Sadat Hosseini, Mohammad Ali Tahririan, Sayyed Alireza Rozati, Mahdi Sepiani, Mehdi Moezi
BACKGROUND: The aim of this study was to determine the diagnostic value of magnetic resonance imaging (MRI) in the diagnosis of knee injuries. MATERIALS AND METHODS: Ninety-eight consecutive patients were enrolled in the study. In all patients, MRI and arthroscopy were performed and the results were compared. RESULTS: MRI was most sensitive in the detection of medial meniscus injuries, and the highest specificity and negative predictive value (NPV) were found in the detection of posterior cruciate ligament injuries...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27897156/quantitative-evaluation-of-the-mechanical-risks-caused-by-focal-cartilage-defects-in-the-knee
#3
Mikko S Venäläinen, Mika E Mononen, Jari Salo, Lasse P Räsänen, Jukka S Jurvelin, Juha Töyräs, Tuomas Virén, Rami K Korhonen
Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography, we present a novel computational model for evaluating changes in local mechanical responses around cartilage defects. Our model, based on data obtained from a human knee in vivo, demonstrated that the most substantial alterations around the defect, as compared to the intact tissue, were observed in minimum principal (compressive) strains and shear strains...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893158/articular-cartilage-scores-in-cranial-cruciate-ligament-deficient-dogs-with-or-without-bucket-handle-tears-of-the-medial-meniscus
#4
Kathryn Kaufman, Brian S Beale, Howard D Thames, W Brian Saunders
OBJECTIVE: To compare articular cartilage scores in cranial cruciate ligament (CCL)-deficient dogs with or without concurrent bucket handle tears (BHT) of the medial meniscus. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned dogs treated with arthroscopy and tibial plateau leveling osteotomy or extracapsular repair for complete CCL rupture (290 stifles from 264 dogs). METHODS: Medical records and arthroscopic images were reviewed...
November 28, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27887880/anamnestic-prediction-of-bucket-handle-compared-to-other-tear-patterns-of-the-medial-meniscus-in-stable-knees
#5
Barak Haviv, Shlomo Bronak, Yona Kosashvili, Rafael Thein
OBJECTIVE: The aim of this study was to analyze and compare the preoperative anamnestic details between patients with an arthroscopic diagnosis of bucket handle and other tear patterns of the medial meniscus in stable knees. METHODS: A total of 204 patients (mean age 49.3 ± 13 years) were included in the study. The mean age was 49.3 ± 13 years. The study group included 65 patients (63 males, 2 females) with an arthroscopic diagnosis of bucket handle tear and the control group included 139 patients (90 males, 49 females) with non-bucket handle tear patterns...
November 23, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27885289/assessment-of-knee-joint-injuries-with-low-field-strength-magnetic-resonance-imaging
#6
O B Panta, N P Neupane, S Songmen, G Gurung
BACKGROUND: Magnetic Resonance Imaging is an appropriate screening tool before therapeutic arthroscopy, making diagnostic arthroscopy unnecessary in most patients. This study aims to evaluate the MRI findings in knee injuries and diagnostic value of low Strength MRI for assessing Meniscal and cruciate ligament tear. METHODS: A cross sectional study was conducted on patients undergoing "Magnetic Resonance Imaging of the Knee" for injuries of the knee and excluded patients undergoing MRI for other causes, poor diagnostic quality MRI and post operative MRI...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27878340/anatomical-risk-evaluation-of-iatrogenic-injury-to-the-infrapatellar-branch-of-the-saphenous-nerve-during-medial-meniscus-arthroscopic-surgery
#7
Guillaume Koch, Agathe Kling, Nitin Ramamurthy, Faramarz Edalat, Roberto Luigi Cazzato, Jean-Luc Kahn, Julien Garnon, Philippe Clavert
PURPOSE: To determine the relationship of the medial meniscus with the infrapatellar branches of the saphenous nerve, the primary goal is to define and characterize different risk areas for these nerves during medial meniscus surgery. METHODS: After dissecting 20 embalmed cadaver knees, we defined 7 readily identifiable anatomical landmarks. For each knee, we recorded 2 morphological criteria and 16 measurements. RESULTS: The most common anatomical course is a main trunk that is 8 mm anterior to the tuberculum adductorium and 60 mm posterior to the midpoint of the medial patellar margin...
November 22, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27869622/acl-deficiency-increases-forces-on-the-medial-femoral-condyle-and-the-lateral-meniscus-with-applied-rotatory-loads
#8
Lucas S McDonald, James Boorman-Padgett, Robert Kent, Kyle Stone, Thomas L Wickiewicz, Andrew D Pearle, Carl W Imhauser
BACKGROUND: The articular surfaces and menisci act with the anterior cruciate ligament (ACL) to stabilize the knee joint. Their role in resisting applied rotatory loads characteristic of instability events is unclear despite commonly observed damage to these intra-articular structures in the acute and chronic ACL injury settings. METHODS: Ten fresh-frozen human cadaveric knees were mounted to a robotic manipulator. Combined valgus and internal rotation torques were applied in the presence and absence of a 300-N compressive load...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27863298/butein-inhibits-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes-and-slows-the-progression-of-osteoarthritis-in-mice
#9
Wenhao Zheng, Hui Zhang, Yonglong Jin, Quan Wang, Linwei Chen, Zhenhua Feng, Hua Chen, Yaosen Wu
Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti-inflammatory effects. This study aimed to assess the effect of butein on human OA chondrocytes and mice OA models induced by destabilization of the medial meniscus (DMM). In vitro, human OA chondrocytes were pretreated with butein at 10, 50μM and subsequently stimulated with IL-1β (10ng/ml) for 24h...
November 14, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27856294/role-of-the-c-c-chemokine-receptor-2-in-a-murine-model-of-injury-induced-osteoarthritis
#10
L Longobardi, J D Temple, L Tagliafierro, H Willcockson, A Esposito, N D'Onofrio, E Stein, T Li, T J Myers, H Ozkan, M L Balestrieri, V Ulici, R F Loeser, A Spagnoli
OBJECTIVE: We previously found in our embryonic studies that proper regulation of the chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate development. In the present study, we examined the role of CCR2 in injury-induced-osteoarthritis (OA). METHOD: We used a murine model of injury-induced-OA (destabilization of medial meniscus, DMM), and systemically blocked CCR2 using a specific antagonist (RS504393) at different times during disease progression...
November 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27851984/intra-articular-therapy-with-recombinant-human-gdf5-arrests-disease-progression-and-stimulates-cartilage-repair-in-the-rat-medial-meniscus-transection-mmt-model-of-osteoarthritis
#11
W R Parrish, B A Byers, D Su, J Geesin, U Herzberg, S Wadsworth, A Bendele, B Story
OBJECTIVE: Investigation of osteoarthritis (OA) risk alleles suggests that reduced levels of growth and differentiation factor-5 (GDF5) may be a precipitating factor in OA. We hypothesized that intra-articular recombinant human GDF5 (rhGDF5) supplementation to the OA joint may alter disease progression. METHODS: A rat medial meniscus transection (MMT) joint instability OA model was used. Animals received either one intra-articular injection, or two or three bi-weekly intra-articular injections of either 30 μg or 100 μg of rhGDF5 beginning on day 21 post surgery after structural pathology had been established...
November 13, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27836674/chondroprotective-activity-of-n-acetyl-phenylalanine-glucosamine-derivative-on-knee-joint-structure-and-inflammation-in-a-murine-model-of-osteoarthritis
#12
F Veronesi, G Giavaresi, M Maglio, A Scotto d'Abusco, L Politi, R Scandurra, E Olivotto, B Grigolo, R M Borzì, M Fini
OBJECTIVE: Osteoarthritis (OA), the most common chronic degenerative joint disease, is characterized by joint structure changes and inflammation, both mediated by the IκB kinase (IKK) signalosome complex. The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKα kinase activity, has been observed in vitro. The present study aims to further clarify the effect of NAPA in counteracting OA progression, in an in vivo mouse model after destabilization of the medial meniscus (DMM)...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27824675/-fat-brook-in-the-popliteal-fossa-cadaveric-and-clinical-investigation-with-magnetic-resonance-imaging
#13
Yoonah Song, Seunghun Lee, Doo-Jin Paik, Jiyoon Bae
OBJECTIVE: This study aimed to describe the "fat brook" (FB) in the popliteal fossa of a cadaver and to evaluate its clinical significance. METHODS: Ten fresh cadaveric knees underwent magnetic resonance imaging and histologic analyses. In addition, magnetic resonance imaging images from 321 patients (108 men, 213 women; mean age, 49.8 years; age range, 5-92 years) were retrospectively reviewed. Two radiologists independently determined the presence/absence of the FB and internal derangement of the knee...
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27824492/evolution-of-intrameniscal-signal-intensity-alterations-detected-on-mri-over-24-months-in-patients-with-traumatic-anterior-cruciate-ligament-tear
#14
Julio Brandao Guimaraes, Luca Facchetti, Benedikt J Schwaiger, Alexandra S Gersing, Sharmila Majumdar, Benjamin C Ma, Xiaojuan Li, Thomas M Link
OBJECTIVE: The objective of our study was to assess the prevalence and evolution of intrameniscal signal-intensity alteration in subjects with an anterior cruciate ligament (ACL) tear over 24 months and compare clinical outcome and changes of cartilage between subjects with and those without this meniscal abnormality. MATERIALS AND METHODS: Fifty-seven subjects with an ACL tear were screened for intrameniscal signal-intensity alteration. Morphologic and compositional MRI was performed before ACL reconstruction and 12 and 24 months after ACL reconstruction...
November 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27808352/suppression-of-cartilage-degeneration-by-intra-articular-injection-of-heparan-sulfate-6-o-endosulfatase-in-a-mouse-osteoarthritis-model
#15
Shuhei Otsuki, Tomohiko Murakami, Yoshinori Okamoto, Yoshiaki Hoshiyama, Shuhei Oda, Masashi Neo
We previously reported that heparan sulfate 6-O endosulfatases (Sulfs) were expressed in articular cartilage, and that the Sulf-1 knockout mouse developed severe knee osteoarthritis. In this study, we hypothesised that intra-articular injection of Sulf-1 would prevent cartilage degeneration. After confirming that 1 mg/ml Sulf-1 did not induce ATDC5 cell death in vitro, gene expression of type II collagen and matrix metalloproteinase (MMP)-13 in the presence of Sulf-1 (1 100 ng/ml) were determined by quantitative real-time polymerase chain reaction...
November 3, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27807116/tibiofemoral-contact-mechanics-with-horizontal-cleavage-tear-and-resection-of-the-medial-meniscus-in-the-human-knee
#16
Jason L Koh, Seung Jin Yi, Yupeng Ren, Todd A Zimmerman, Li-Qun Zhang
BACKGROUND: The meniscus is known to increase the contact area and decrease contact pressure in the tibiofemoral compartments of the knee. Radial tears of the meniscal root attachment along with partial resections of the torn meniscal tissue decrease the contact area and increase pressure; however, there is a lack of information on the effects of a horizontal cleavage tear (HCT) and partial leaf meniscectomy of such tears on tibiofemoral contact pressure and contact area. METHODS: Twelve fresh-frozen human cadaveric knees were tested under 10 conditions: 5 serial conditions of posterior medial meniscectomy (intact meniscus, HCT, repaired HCT, inferior leaf resection, and resection of both inferior and superior leaves), each at 2 knee flexion angles (0° and 60°) under an 800-N axial load...
November 2, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27805288/meniscal-regeneration-after-resection-of-the-anterior-half-of-the-medial-meniscus-in-mice
#17
Kanehiro Hiyama, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya, Kunikazu Tsuji
Various animal studies have indicated that reduced meniscal function significantly exacerbates articular-cartilage degeneration. Despite the importance of meniscal function for joint homeostasis and prevention of osteoarthritis, the healing process after meniscal injury and the regenerative process after meniscus removal have not been studied in detail. In this study, we examined the process of meniscal regeneration and cartilage degeneration after meniscectomy in mice. The left anterior halves of the medial menisci in male C57Bl/6J mice were resected, and histological assessment of the process of meniscal regeneration was conducted on day 3 and 2, 4, and 6 weeks after the surgical procedure...
November 2, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27803940/association-between-meniscal-and-chondral-lesions-and-timing-of-anterior-cruciate-ligament-reconstruction
#18
Gustavo Constantino de Campos, Wilton Nery, Paulo Eduardo Portes Teixeira, Paulo Henrique Araujo, Wilson de Mello Alves
BACKGROUND: Rupture of the anterior cruciate ligament (ACL) is a common sports injury and is known to be associated with an increased risk of knee osteoarthritis. Several studies have indicated that the risk of additional injuries to the menisci and articular cartilage increases with delays in the treatment of ACL tears. However, no consensus has been reached regarding the ideal timing for ACL reconstruction in terms of preventing secondary lesions. PURPOSE: To determine how the time elapsed between an ACL lesion and its reconstruction affects the incidence of meniscal and chondral lesions...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27802925/effects-of-suture-site-or-penetration-depth-on-anchor-location-in-all-inside-meniscal-repair
#19
Ryohei Uchida, Tatsuo Mae, Kunihiko Hiramatsu, Ryo Iuchi, Kazutaka Kinugasa, Konsei Shino, Hideki Yoshikawa, Ken Nakata
BACKGROUND: To evaluate the effects of suture site or penetration depth on anchor location in all-inside meniscal repair. METHODS: Eight fresh-frozen cadaveric knees were evaluated after meniscal repair using eight FasT-Fix360 (FF360) devices (Smith & Nephew Endoscopy, Andover, MA) (16 anchors) for each knee. The penetration depth was 14mm, the distance same from the periphery to insertion point, in four knees (Group A) and that in the remaining four knees (Group B) was 18mm...
October 29, 2016: Knee
https://www.readbyqxmd.com/read/27797605/quantitative-histological-grading-methods-to-assess-subchondral-bone-and-synovium-changes-subsequent-to-medial-meniscus-transection-in-the-rat
#20
Heidi E Kloefkorn, Kyle D Allen
AIM OF THE STUDY: The importance of the medial meniscus to knee health is demonstrated by studies which show meniscus injuries significantly increase the likelihood of developing osteoarthritis (OA), and knee OA can be modeled in rodents using simulated meniscus injuries. Traditionally, histological assessments of OA in these models have focused on damage to the articular cartilage; however, OA is now viewed as a disease of the entire joint as an organ system. The aim of this study was to develop quantitative histological measures of bone and synovial changes in a rat medial meniscus injury model of knee OA...
October 31, 2016: Connective Tissue Research
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