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https://www.readbyqxmd.com/read/28544596/deletion-of-the-prostaglandin-d2-receptor-dp1-exacerbates-aging-associated-and-instability-induced-osteoarthritis
#1
Yassine Ouhaddi, Sarah-Salwa Nebbaki, Lauris Habouri, Hassan Afif, Bertrand Lussier, Mohit Kapoor, Shuh Narumiya, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
OBJECTIVE: The D prostanoid receptor 1 (DP1), a receptor for prostaglandin D2 (PGD2 ), plays important roles in inflammation and cartilage metabolism. However, its role in the pathogenesis of osteoarthritis (OA) remains unknown. We undertook this study to explore the roles of DP1 in the development of OA and to evaluate the efficacy of a DP1 selective agonist in the treatment of OA. METHODS: We compared the development of aging-associated OA and destabilization of the medial meniscus (DMM)-induced OA in DP1-deficient (DP1-/-) and wild-type (WT) mice...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28539595/deletion-of-runx2-in-articular-chondrocytes-decelerates-the-progression-of-dmm-induced-osteoarthritis-in-adult-mice
#2
Lifan Liao, Shanxing Zhang, Jianhong Gu, Takeshi Takarada, Yukio Yoneda, Jian Huang, Lan Zhao, Chun-do Oh, Jun Li, Baoli Wang, Meiqing Wang, Di Chen
Runx2 may play an important role in development of osteoarthritis (OA). However, the specific role of Runx2 in articular chondrocyte function and in OA development in adult mice has not been fully defined. In this study, we performed the destabilization of the medial meniscus (DMM) surgery at 12-week-old mice to induce OA in adult Runx2 (Agc1CreER) mice, in which Runx2 was specifically deleted in Aggrecan-expressing chondrocytes by administering tamoxifen at 8-weeks of age. Knee joint samples were collected 8- and 12-weeks post-surgery and analyzed through histology, histomorphometry and micro-computed tomography (μCT)...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536794/good-clinical-results-can-be-obtained-along-with-reduced-risk-of-tunnel-communication-with-a-new-technique-in-concomitant-meniscus-transplantation-and-acl-reconstruction
#3
Murat Bozkurt, Mesut Tahta, Mustafa Akkaya, Cetin Isik, Safa Gursoy
PURPOSE: The purpose of this study was to introduce our technical modification for concomitant meniscus transplantation and ACL reconstruction with preliminary results of our cases. METHODS: The current study comprised of two sections: first is the cadaveric study of 20 specimens. The distances between tunnel entry and exit points of tunnels for 27 meniscal transplants and ACL reconstruction in CT slices were measured. The second section was evaluation of our cases including six patients...
May 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28536729/clinics-in-diagnostic-imaging-177-medical-meniscus-bucket-handle-tear-with-medial-oblique-meniscomeniscal-ligament
#4
Poh Lye Paul See
A 29-year-old man with a previous football injury to his left knee presented with pain of the same knee. The patient twisted it as he was turning a corner quickly while going up the stairs, leading to internal rotation of his femur on his tibia with his knee in flexion. MR imaging revealed a bucket-handle tear of the medial meniscus, as well as a complete tear of the anterior cruciate ligament. However, image interpretation was complicated by the presence of a medial oblique meniscomeniscal ligament, a rare normal variant among intermeniscal ligaments of the knee...
May 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28534321/does-anatomic-single-bundle-acl-reconstruction-using-hamstring-autograft-produce-anterolateral-meniscal-root-tearing
#5
Sebastián Irarrázaval, Angel Masferrer-Pino, Maximiliano Ibañez, Tamer M A Shehata, María Naharro, Joan C Monllau
BACKGROUND: To determine if tibial tunnel reaming during anatomic single-bundle anterior cruciate ligament (ACL) reconstruction using hamstring autograft can result in anterolateral meniscal root injury, as diagnosed by magnetic resonance imaging (MRI). METHODS: A case series of 104 primary anatomic single-bundle ACL reconstructions using hamstring autograft was retrospectively reviewed. Pre- and post-operative (>1 year) MRIs were radiologically evaluated for each patient, with a lateral meniscus extrusion > 3 mm at the level of the medial collateral ligament midportion on a coronal MRI, to establish anterolateral meniscal root injury...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28533596/the-ratio-of-medial-and-lateral-hamstring-muscle-thickness-does-not-correlate-with-the-lateral-tibial-rotation-angle-in-the-standing-position-in-healthy-young-adults
#6
Dong-Soo Lee, Sung-Dae Choung, Seung-Won Lee, Hye Rim Suh, Jae-Hoon Shim
[Purpose] To investigate the relationship between the lateral tibial rotation angle during knee joint flexion and the medial and lateral hamstring muscle thickness ratio during knee joint extension while resting, doing nothing, in upright standing position. The lateral tibial torsion is an important factor of orthopedic knee joint diseases as well as other weight bearing joint diseases such as osteoarthritis, meniscus syndrome, anterior cruciate ligament rupture, etc. [Subjects and Methods] Thirty healthy young adults participated in this study...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533592/articular-chondrocyte-alignment-in-the-rat-after-surgically-induced-osteoarthritis
#7
Hideaki Takahashi, Hiroyuki Tamaki, Noriaki Yamamoto, Hideaki Onishi
[Purpose] Chondrocytes in articular cartilage are aligned as columns from the joint surface. Notably, loss of chondrocyte and abnormalities of differentiation factors give rise to osteoarthritis (OA). However, the relationship between chondrocyte alignment and OA progression remains unclear. This study was performed to investigate temporal alterations in surgically-induced OA rats. [Subjects and Methods] Thirteen-week-old Wistar rats (n=30) underwent destabilized medial meniscus surgery in their right knee and sham surgery in their left knee...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28524271/histological-characteristics-of-knee-menisci-in-patients-with-osteoarthritis
#8
D McDaniel, E Tilton, K Dominick, K Flory, T Ernest, J C Johnson, D C Main, P Kondrashov
INTRODUCTION: Existing data indicate knee menisci in patients with osteoarthritis (OA) show tearing, maceration, and fragmentation, but little is known about the change in histological structure. The aim of this study was to evaluate change in the menisci histological structure in patients with clinically diagnosed knee OA. MATERIALS AND METHODS: Fourteen patients undergoing surgical treatment of knee OA (OA group) and 14 cadaveric knees (control group) were assessed...
May 19, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28523339/medial-meniscal-extrusion-a-validation-study-comparing-different-methods-of-assessment
#9
Luke D Jones, Stephen J Mellon, Neil Kruger, Andrew P Monk, Andrew J Price, David J Beard
PURPOSE: Longitudinal cohort studies of knee OA aetiology use MRI to assess meniscal extrusion within the same knee at sequential time points. A validated method of assessment is required to ensure that extrusion is measured at the same location within the knee at each time point. Absolute perpendicular extrusion from the tibial edge can be assessed using the reference standard of segmentation of the tibia and medial meniscus. This is labour intensive and unsuitable for large cohorts...
April 21, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28522452/arthroscopic-partial-meniscectomy-versus-placebo-surgery-for-a-degenerative-meniscus-tear-a-2-year-follow-up-of-the-randomised-controlled-trial
#10
Raine Sihvonen, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Heikki Nurmi, Juha Kalske, Anna Ikonen, Timo Järvelä, Tero Ah Järvinen, Kari Kanto, Janne Karhunen, Jani Knifsund, Heikki Kröger, Tommi Kääriäinen, Janne Lehtinen, Jukka Nyrhinen, Juha Paloneva, Outi Päiväniemi, Marko Raivio, Janne Sahlman, Roope Sarvilinna, Sikri Tukiainen, Ville-Valtteri Välimäki, Ville Äärimaa, Pirjo Toivonen, Teppo Ln Järvinen
OBJECTIVE: To assess if arthroscopic partial meniscectomy (APM) is superior to placebo surgery in the treatment of patients with degenerative tear of the medial meniscus. METHODS: In this multicentre, randomised, participant-blinded and outcome assessor-blinded, placebo-surgery controlled trial, 146 adults, aged 35-65 years, with knee symptoms consistent with degenerative medial meniscus tear and no knee osteoarthritis were randomised to APM or placebo surgery. The primary outcome was the between-group difference in the change from baseline in the Western Ontario Meniscal Evaluation Tool (WOMET) and Lysholm knee scores and knee pain after exercise at 24 months after surgery...
May 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28521823/t1rho-and-t2-relaxation-times-of-the-normal-adult-knee-meniscus-at-3t-analysis-of-zonal-differences
#11
Shoichiro Takao, Tan B Nguyen, Hon J Yu, Shigeo Hagiwara, Yasuhito Kaneko, Taiki Nozaki, Seiji Iwamoto, Maki Otomo, Ran Schwarzkopf, Hiroshi Yoshioka
BACKGROUND: Prior studies describe histological and immunohistochemical differences in collagen and proteoglycan content in different meniscal zones. The aim of this study is to evaluate horizontal and vertical zonal differentiation of T1rho and T2 relaxation times of the entire meniscus from volunteers without symptom and imaging abnormality. METHODS: Twenty volunteers age between 19 and 38 who have no knee-related clinical symptoms, and no history of prior knee surgeries were enrolled in this study...
May 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28520086/activated-fgfr3-prevents-subchondral-bone-sclerosis-during-the-development-of-osteoarthritis-in-transgenic-mice-with-achondroplasia
#12
Toshiaki Okura, Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Taisuke Seki, Naoki Ishiguro, Hiroshi Kitoh
The purpose of this study is to investigate the morphometric changes of the subchondral bone during the development of osteoarthritis (OA) in transgenic mice with achondroplasia (Fgfr3(ach) ) carrying a heterozygous gain-of-function mutation in Fgfr3. Two OA models (spontaneously developed with age: the aging model, and surgically induced by destabilization of the medial meniscus: the DMM model) were established. Articular cartilage, epiphysis and metaphysis of the knee joint were histologically and morphometrically compared between wild-type mice and Fgfr3(ach) mice in both OA models...
May 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28511868/tunnel-malpositions-in-anterior-cruciate-ligament-risk-cartilaginous-changes-and-bucket-handle-meniscal-tear-arthroscopic-survey-in-both-primary-and-revision-surgery
#13
Daisuke Chiba, Eiichi Tsuda, Harehiko Tsukada, Kohei Iio, Yasuyuki Ishibashi
OBJECTIVES: There are not many chances to arthroscopically reassess how graft tunnel malpositions in primary anterior cruciate ligament reconstruction (ACLR) associate with intra-articular degeneration in revision ACLR. This study was aimed to evaluate whether radiographic tunnel position in primary ACLR affect cartilaginous changes and bucket-handle meniscus tears in revision ACLR. METHODS: Thirty-five patients who underwent revision ACLR were recruited; their primary surgeries were single-bundle reconstructions...
May 13, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28508006/early-osteoarthritis-after-untreated-anterior-meniscal-root-tears-an-in-vivo-animal-study
#14
Brett D Steineman, Robert F LaPrade, Kelly S Santangelo, Brent T Warner, Laurie R Goodrich, Tammy L Haut Donahue
BACKGROUND: Meniscal root tears cause menisci and their insertions to inadequately distribute loads and potentially leave underlying articular cartilage unprotected. Untreated meniscal root tears are becoming increasingly recognized to induce joint degradation; however, little information is known about anterior meniscal root tears and how they affect joint tissue. PURPOSE: To observe the early degenerative changes within the synovial fluid, menisci, tibial articular cartilage, and subchondral bone after arthroscopic creation of untreated anterior meniscal root tears...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28507957/arthroscopic-synovectomy-in-bilateral-lipoma-arborescens
#15
Paolo Fornaciari, Pascal A Schai, Michael O Kurrer, G Ulrich Exner
INTRODUCTION: Lipoma arborescens (LA) is an uncommon condition that consists of a villous lipomatous proliferation of the synovial membrane. Open synovectomy has been previously selected as a curative treatment option. In recent years, some authors have published good results with arthroscopic interventions. We describe a well-documented case of bilateral LA of the knees treated with staged arthroscopic synovectomy. CASE REPORT: A 48-year-old North American woman without a history of trauma presented with recurrent effusions and mild pain in both knee joints for many years...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28497247/-medial-closed-wedge-osteotomy-of-the-distal-femur-in-biplanar-technique-and-a-specific-plate-fixator
#16
REVIEW
P Lobenhoffer, K Kley, D Freiling, R van Heerwaarden
OBJECTIVE: Correction of distal femur deformity by closed-wedge biplanar osteotomy. INDICATIONS: Metaphyseal frontal plane deformities of the femur. CONTRAINDICATIONS: Osteoarthritis of the contralateral compartment, total loss of the contralateral meniscus, acute/chronic infection, limited range-of-motion, poor soft-tissue conditions at site of surgery. SURGICAL TECHNIQUE: Skin incision at metaphyseal area of femur...
May 11, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28484790/lateral-meniscus-posterior-root-tear-contributes-to-anterolateral-rotational-instability-and-meniscus-extrusion-in-anterior-cruciate-ligament-injured-patients
#17
Takao Minami, Takeshi Muneta, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Hideyuki Koga
PURPOSE: The purposes of this study were to investigate (1) meniscus status and clinical findings in anterior cruciate ligament (ACL)-injured patients to clarify associations between the meniscus posterior root tear (PRT) and knee instability, and (2) magnetic resonance imaging (MRI) findings of the PRT to clarify sensitivity and specificity of MRI and prevalence of meniscus extrusion. METHODS: Three hundred and seventeen patients with primary ACL reconstruction were included...
May 8, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28472738/cartilage-lesions-in-feline-stifle-joints-associations-with-articular-mineralizations-and-implications-for-osteoarthritis
#18
Alexandra Leijon, Charles J Ley, Antonia Corin, Cecilia Ley
Feline stifle osteoarthritis (OA) is common, however little is known about the early stages of the disease. Furthermore, the importance of small articular mineralizations (AMs) in feline stifle OA is controversial. This study aimed to describe microscopic articular cartilage lesions and to investigate associations between cartilage lesions and AMs, synovitis, osteochondral junction findings and subchondral bone sclerosis. Stifles of 29 cats, aged 1-23years and euthanized for reasons other than stifle disease, were examined...
April 19, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28471817/effects-of-tibial-rotational-guided-growth-on-the-geometries-of-tibial-plateaus-and-menisci-in-rabbits
#19
Figen Sevil-Kilimci, Mutlu Cobanoglu, Mehmet K Ocal, Deniz Korkmaz, Emre Cullu
BACKGROUND: There are studies on the use of oblique plate over epiphyses for rotational deformities but the effects of this method on bone are not yet known. The purpose of this study was to determine the effect and rebound effect of rotational-guided growth on the geometries of the tibial plateaus and menisci in a rabbit model of tibial axial rotation. METHODS: Thirty male rabbits were 6 weeks old when medial and lateral plates were applied to the proximal tibias of the left side...
May 3, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28471543/mri-and-biomechanics-multidimensional-data-analysis-reveals-r2-r1%C3%AF-as-an-early-predictor-of-cartilage-lesion-progression-in-knee-osteoarthritis
#20
Valentina Pedoia, Jenny Haefeli, Kazuhito Morioka, Hsiang-Ling Teng, Lorenzo Nardo, Richard B Souza, Adam R Ferguson, Sharmila Majumdar
PURPOSE: To couple quantitative compositional MRI, gait analysis, and machine learning multidimensional data analysis to study osteoarthritis (OA). OA is a multifactorial disorder accompanied by biochemical and morphological changes in the articular cartilage, modulated by skeletal biomechanics and gait. While we can now acquire detailed information about the knee joint structure and function, we are not yet able to leverage the multifactorial factors for diagnosis and disease management of knee OA...
May 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
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