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https://www.readbyqxmd.com/read/29775482/risk-of-venous-thromboembolism-in-association-with-factor-v-leiden-in-cancer-patients-the-edith-case-control-study
#1
Adeline Heraudeau, Aurélien Delluc, Mickaël Le Henaff, Karine Lacut, Christophe Leroyer, Benoit Desrues, Francis Couturaud, Cécile Tromeur
BACKGROUND: Cancer and factor V Leiden mutation are both risk factors for venous thromboembolism (VTE). Cancer critically increases the thrombotic risk whereas Factor V Leiden is the most common pro-thrombotic mutation. The impact of the factor V Leiden on the risk of VTE in cancer patients remains uncertain. OBJECTIVE: To assess the impact of factor V Leiden mutation in cancer-associated thrombosis. METHODS: The EDITH hospital-based case-control study enrolled 182 patients with cancer and VTE as well as 182 control patients with cancer, matched for gender, age and cancer location, between 2000 and 2012, in the University Hospital of Brest...
2018: PloS One
https://www.readbyqxmd.com/read/29770627/knowledge-attitude-practice-and-barriers-of-cervical-cancer-screening-among-women-living-in-mid-western-rural-nepal
#2
Niresh Thapa, Muna Maharjan, Marcia A Petrini, Rajiv Shah, Swati Shah, Narayani Maharjan, Navin Shrestha, Hongbing Cai
OBJECTIVE: To find out the knowledge, attitude, practice, and barriers of cervical cancer screening in mid-western rural, Nepal. METHODS: A hospital-based cross-sectional study was conducted. Women aged 20 or more were interviewed using a structured questionnaire regarding the socio-demographic information, knowledge, attitude, practice, and barriers to the cervical cancer screening. RESULTS: Total of 360 participants were recruited for this study, mean age was 30...
April 4, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29748006/risk-factors-for-pulmonary-nodules-in-north-china-a-prospective-cohort-study
#3
Yu-Tong He, Ya-Chen Zhang, Gao-Feng Shi, Qi Wang, Qian Xu, Di Liang, Yu Du, Dao-Juan Li, Jing Jin, Bao-En Shan
OBJECTIVES: Pulmonary nodules have become common incidental findings with the widespread use of computed tomography (CT) technology. Such nodules have the potential to become early lung cancer lesions, so understanding more about factors that may be associated with them is important. MATERIALS AND METHODS: The present work was based on a large prospective cohort comprising 32,438 participants in Hebei Province (China) between January 2014 and March 2016. Participants aged 40-75 years completed a questionnaire, underwent low-dose CT (LDCT), and were followed up to March 2017...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29746427/risk-factors-for-basal-cell-carcinoma-in-men-younger-than-40-years-a-case-control-study
#4
Kathleen M Nemer, Tyler M Bauman, Alan S Boyd
BACKGROUND: Basal cell carcinoma (BCC) is the most common malignancy in the United States and is more prevalent in older populations. OBJECTIVE: The aim of this study was to investigate BCC risk factors in male patients younger than 40 years. MATERIALS AND METHODS: A consecutive series of male patients with pathology-proven BCC and younger than 40 years at time of diagnosis were retrospectively identified along with matched controls. Phone interviews were conducted using a structured questionnaire, and differences between patients with and without BCC were investigated...
May 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29718843/predicting-the-risk-for-colorectal-cancer-with-personal-characteristics-and-fecal-immunochemical-test
#5
Wen Li, Li-Zhong Zhao, Dong-Wang Ma, De-Zheng Wang, Lei Shi, Hong-Lei Wang, Mo Dong, Shu-Yi Zhang, Lei Cao, Wei-Hua Zhang, Xi-Peng Zhang, Qing-Huai Zhang, Lin Yu, Hai Qin, Xi-Mo Wang, Sam Li-Sheng Chen
We aimed to predict colorectal cancer (CRC) based on the demographic features and clinical correlates of personal symptoms and signs from Tianjin community-based CRC screening data.A total of 891,199 residents who were aged 60 to 74 and were screened in 2012 were enrolled. The Lasso logistic regression model was used to identify the predictors for CRC. Predictive validity was assessed by the receiver operating characteristic (ROC) curve. Bootstrapping method was also performed to validate this prediction model...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29710224/hormone-replacement-therapy-after-oophorectomy-and-breast-cancer-risk-among-brca1-mutation-carriers
#6
Joanne Kotsopoulos, Jacek Gronwald, Beth Y Karlan, Tomasz Huzarski, Nadine Tung, Pal Moller, Susan Armel, Henry T Lynch, Leigha Senter, Andrea Eisen, Christian F Singer, William D Foulkes, Michelle R Jacobson, Ping Sun, Jan Lubinski, Steven A Narod
Importance: Prophylactic bilateral salpingo-oophorectomy is recommended for BRCA1 mutation carriers to prevent ovarian cancer. Whether or not hormone replacement therapy (HRT) initiated after oophorectomy is associated with an increased risk of breast cancer has not been evaluated in a prospective study. Objective: To determine the association between HRT use and BRCA1-associated breast cancer. Design, Setting, and Participants: A prospective, longitudinal cohort study of BRCA1 and BRCA2 mutation carriers from 80 participating centers in 17 countries was conducted between 1995 and 2017 with a mean follow-up of 7...
April 19, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29706632/distress-uncertainty-and-positive-experiences-associated-with-receiving-information-on-personal-genomic-risk-of-melanoma
#7
Amelia K Smit, Ainsley J Newson, Megan Best, Caro-Anne Badcock, Phyllis N Butow, Judy Kirk, Kate Dunlop, Georgina Fenton, Anne E Cust
The aim of this research was to understand how genomics-based personal melanoma risk information impacts psychological and emotional health outcomes in the general population. In a pilot randomized controlled trial, participants (n = 103) completed the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire, 3 months after receiving personal melanoma genomic risk information. Mean scores for MICRA items and subscales were stratified by genomic risk group (low, average, high), gender, education, age, and family history of melanoma...
April 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29706189/risk-factors-for-salivary-gland-cancers-in-france-results-from-a-case-control-study-the-icare-study
#8
Loredana Radoï, Christine Barul, Gwenn Menvielle, Matthieu Carton, Mireille Matrat, Marie Sanchez, Corinne Pilorget, Michel Velten, Isabelle Stücker, Danièle Luce
OBJECTIVES: Epidemiological studies on the risk factors for salivary gland cancers (SGC) are rare, concern a small sample size, and show inconsistent results. The aim of the present work was to analyze several risk factors for SGC, using the data from the ICARE study, a multicenter, population-based case-control study. MATERIALS AND METHODS: Data from 73 SGC cases and 3555 controls were collected using a standardized questionnaire on lifestyle habits, personal and family medical history, and lifetime occupational history...
May 2018: Oral Oncology
https://www.readbyqxmd.com/read/29702294/worldwide-practice-patterns-in-lynch-syndrome-diagnosis-and-management-based-on-data-from-the-international-mismatch-repair-consortium
#9
Jennifer Y Pan, Robert W Haile, Allyson Templeton, Finlay Macrae, FeiFei Qin, Vandana Sundaram, Uri Ladabaum
BACKGROUND AND AIMS: Families with a history of Lynch syndrome often do not adhere to guidelines for genetic testing and screening. We investigated practice patterns related to Lynch syndrome worldwide, to ascertain potential targets for research and public policy efforts METHODS: We collected data from the International Mismatch Repair Consortium [IMRC], which comprises major research and clinical groups engaged in the care of families with Lynch syndrome worldwide. IMRC institutions were invited to complete a questionnaire to characterize diagnoses of Lynch syndrome and management practice patterns...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29693968/determinants-of-breast-cancer-screening-by-mammography-in-women-referred-to-health-centers-of-urmia-iran
#10
Fatemeh Moghaddam Tabrizi, Sakineh Vahdati, Shahriar Khanahmadi, Samira Barjasteh
Background: In women, breast cancer accounts for 30 percent of all cancers and it is the second leading cause of mortality. Mammography is considered an effective procedure to detect early breast cancer recommended by World Health Organization. This study was aimed to evaluate breast cancer screening determinants in women referred to health centers of Urmia for mammography in 2017. Materials and Methods: In this descriptive-analytic cross-sectional study, 348 women referred to health centers of Urmia were selected using multistage sampling...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29693426/usual-cruciferous-vegetable-consumption-and-ovarian-cancer-a-case-control-study
#11
Hallie McManus, Kirsten B Moysich, Li Tang, Janine Joseph, Susan E McCann
Ovarian cancer is the fifth leading cause of cancer-related deaths among women, primarily due to diagnosis at late stages. Therefore, identification of modifiable risk factors for this disease is warranted. Using the Patient Epidemiology Data System (PEDS), collected from 1981 to 1998 at Roswell Park Cancer Institute, Buffalo, NY, we conducted a hospital-based, case-control analysis of self-reported cruciferous vegetable intake and ovarian cancer among 675 women with primary, incident ovarian cancer, and 1275 without cancer...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29687205/the-impact-of-hormonal-contraceptives-on-breast-cancer-pathology
#12
Jesse A Dorchak, Sifat Maria, Joseph L Guarinoni, Anette Duensing, Stella Somiari, Jane Cavanaugh, Brenda Deyarmin, Hai Hu, Joji Iida, Craig D Shriver, Paula A Witt-Enderby
This retrospective case series study, using data obtained through questionnaires and histopathological diagnoses from 656 patients enrolled in the Department of Defense (DoD) Clinical Breast Care Project (CBCP), evaluated associations between hormonal contraceptive use and breast cancer pathology including benign breast pathologies. Three combination hormonal contraceptive agents (COCs) Lo Ovral (LO), Ortho Novum (ON), and Ortho Tri-Cyclen (OTC) were evaluated as they represented the most commonly used hormonal contraceptives in our cohort...
April 23, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29662929/colorectal-cancer-screening-what-is-the-population-s-opinion
#13
Cristina Teixeira, Cláudio Martins, Daniel Trabulo, Suzane Ribeiro, Cláudia Cardoso, João Mangualde, Ricardo Freire, Élia Gamito, Ana Luisa Alves, Isabelle Cremers, Ana Paula Oliveira
Background: Colorectal cancer (CRC) is the first cause of death by cancer in Portugal and mortality has been increasing in the last 30 years. Materials and Methods: During a raising awareness campaign performed by our Gastroenterology Department, in Setúbal, Portugal, an anonymous written questionnaire was developed and presented in order to evaluate the population's knowledge and attitude regarding CRC screening. Results: The following results were reported: 140 persons; mean age 54...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29627803/danish-centre-for-strategic-research-in-type-2-diabetes-dd2-project-cohort-of-newly-diagnosed-patients-with-type-2-diabetes-a-cohort-profile
#14
Diana Hedevang Christensen, Sia Kromann Nicolaisen, Klára Berencsi, Henning Beck-Nielsen, Jørgen Rungby, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Allan Vaag, Henrik Toft Sørensen, Jens Steen Nielsen, Reimar Wernich Thomsen
PURPOSE: The aim of this article is to provide a detailed description of the ongoing nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort and biobank. The DD2 cohort continuously enrols newly diagnosed patients with type 2 diabetes (T2D) throughout Denmark. The overall goal of the DD2 project is to establish a large and data-rich T2D cohort that can serve as a platform for exhaustive T2D research including (1) improved genotypic and phenotypic characterisation of T2D, (2) intervention studies of more individualised T2D treatment, (3) pharmacoepidemiological studies and (4) long-term follow-up studies on predictors of T2D complications and prognosis...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29618015/high-fear-of-disease-occurrence-is-associated-with-low-quality-of-life-in-patients-with-multiple-endocrine-neoplasia-type-1-men1-results-from-the-dutch-men1-study-group
#15
Rachel S van Leeuwaarde, Carolina R C Pieterman, Eveline M A Bleiker, Olaf M Dekkers, Anouk N van der Horst-Schrivers, Ad R Hermus, Wouter W de Herder, Madeleine L Drent, Peter H Bisschop, Bas Havekes, Menno R Vriens, Gerlof D Valk
Objective: Multiple Endocrine Neoplasia type 1 (MEN1) is a hereditary disease characterized by a high risk of developing primary hyperparathyroidism, duodenopancreatic neuroendocrine tumors (dpNETs) and pituitary tumors (PIT). Up to now, it is unclear if having MEN1 leads to psychological distress because of fear of disease occurrence (FDO), thereby potentially affecting quality of life. Design: A cross-sectional study was performed using the Dutch MEN1 cohort. All patients received the Cancer Worry Scale (score ≥ 14 reflecting high FDO), the SF-36 Health Related Quality of Life questionnaire (SF-36) and questions on sociodemographic and medical history...
March 30, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29617794/reproductive-intentions-and-use-of-reproductive-health-care-among-female-survivors-of-childhood-cancer
#16
M van Dijk, M H van den Berg, A Overbeek, C B Lambalk, M M van den Heuvel-Eibrink, W J Tissing, L C Kremer, H J van der Pal, J J Loonen, B Versluys, D Bresters, G J L Kaspers, F E van Leeuwen, E van Dulmen-den Broeder
STUDY QUESTION: Do female childhood cancer survivors (CCSs) express a decreased desire to have children and do they use reproductive health care more often compared to women without a history of cancer? SUMMARY ANSWER: Overall, no difference was found in the desire to have children between CCSs and controls, whereas CCSs consult a fertility specialist more often, at a younger age, and sooner after their first attempt at conceiving. WHAT IS KNOWN ALREADY: Female CCSs may face a shorter than anticipated reproductive window as a result of their cancer treatment...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29603817/utilisation-of-hepatocellular-carcinoma-screening-in-australians-at-risk-of-hepatitis-b-virus-related-carcinoma-and-prescribed-anti-viral-therapy
#17
Suzanne Sheppard-Law, Iryna Zablotska-Manos, Melissa Kermeen, Susan Holdaway, Alice Lee, Jacob George, Amany Zekry, Lisa Maher
AIMS AND OBJECTIVES: This study aimed to investigate HCC screening utilisation and factors associated with utilisation among patients prescribed HBV anti-viral therapy and at risk of HCC. BACKGROUND: The incidence of hepatocellular carcinoma (HCC) has increased in Australia over the past three decades with chronic hepatitis B virus (HBV) infection a major contributor. HCC surveillance programs aim to detect cancers early enabling curative treatment options, longer survival and longer times to recurrence...
March 31, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29599518/psychological-outcomes-and-surgical-decisions-after-genetic-testing-in-women-newly-diagnosed-with-breast-cancer-with-and-without-a-family-history
#18
Bettina Meiser, Veronica F Quinn, Gillian Mitchell, Kathy Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Rachel Susman, Michael T Bowen, Llew Mills, Judy Kirk
In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and/or ovarian may be more vulnerable to psychological sequelae arising from TFGT. We compared the impact of TFGT in women with (FH+) and without (FH-) a strong family history on psychological adjustment and surgical decisions. Women aged <50 years with high-risk features were offered TFGT before definitive breast cancer surgery and completed self-report questionnaires at four time points over 12 months...
March 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29595811/familial-communication-and-cascade-testing-among-relatives-of-brca-population-screening-participants
#19
Sari Lieberman, Amnon Lahad, Ariela Tomer, Sivan Koka, Malka BenUziyahu, Aviad Raz, Ephrat Levy-Lahad
PurposePopulation BRCA1/BRCA2 screening identifies carriers irrespective of family history, yet this information is actionable for relatives. We examined familial communication rates and cascade testing in the screening setting and assessed sociodemographic and psychosocial predictors.MethodsParticipants in a BRCA1/BRCA2 screening study of healthy Ashkenazi Jews self-administered a family communication questionnaire. Intent to communicate was determined before genetic status was known, along with result communication (carriers and noncarriers) 6 months and 2 years after enrollment...
March 29, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29549240/vegetarian-diet-change-in-dietary-patterns-and-diabetes-risk-a-prospective-study
#20
Tina H T Chiu, Wen-Harn Pan, Ming-Nan Lin, Chin-Lon Lin
BACKGROUND/OBJECTIVES: Vegetarian diets are inversely associated with diabetes in Westerners but their impact on Asians-whose pathophysiology differ from Westerners-is unknown. We aim to investigate the association between a vegetarian diet, change in dietary patterns and diabetes risk in a Taiwanese Buddhist population. METHODS: We prospectively followed 2918 non-smoking, non-alcohol drinking Buddhists free of diabetes, cancer, and cardiovascular diseases at baseline, for a median of 5 years, with 183 incident diabetes cases confirmed...
March 9, 2018: Nutrition & Diabetes
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