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https://www.readbyqxmd.com/read/28720130/psychosocial-and-behavioral-impact-of-breast-cancer-risk-assessed-by-testing-for-common-risk-variants-protocol-of-a-prospective-study
#1
Tatiane Yanes, Bettina Meiser, Mary-Anne Young, Rajneesh Kaur, Gillian Mitchell, Kristine Barlow-Stewart, Tony Roscioli, Jane Halliday, Paul James
BACKGROUND: The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testing for common risk variants can provide useful information for women who would otherwise receive uninformative results by traditional monogenic testing. Despite increasing support for the utility of common risk variants in hereditary breast cancer, research findings have not yet been integrated into clinical practice...
July 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28719413/evaluation-of-a-new-genetic-family-history-screening-questionnaire-for-identifying-lynch-syndrome
#2
Dawn S Harrison, Marilyn Handley
Family history is essential when screening for hereditary cancer syndromes. This article explores if a detailed genetic family history questionnaire is more effective in identifying at-risk individuals for Lynch syndrome than a basic family health questionnaire.
August 17, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28711897/studying-risk-factors-for-skin-cancer-development
#3
Оlena О Оshyvalova
INTRODUCTION: In most countries with a population of mainly European origin, non-melanoma skin carcinoma incidence rate has increased over the last decade. Understanding of what is the best way to identify people at high risk for skin cancer development will help to optimize the strategy for prevention and treatment tactics. Aim of the research involves studying risk factors for skin cancer development in patients with cutaneous squamous cell carcinoma and squamous cell carcinoma in situ (cSCC and SCCis correspondingly) and patients with actinic keratosis (AK)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28707297/functional-gastrointestinal-disorders-in-children-from-low-socio-economic-status-and-helicobacter-pylori-infection
#4
F Jaime, A Villagrán, C Hernández, M Ortiz, C Serrano, P R Harris
BACKGROUND: Most studies on functional gastrointestinal disorders (FGIDs) in children are based on data from the northern hemisphere. Scientific reports are arising in South American population, but little is still known about children from low socio-economic status (SES), where Helicobacter pylori infection is endemic. Our objective was to evaluate the prevalence of FGIDs in school children from low SES and its relationship with H. pylori infection. METHODS: Children from 3 public schools of low SES from Santiago de Chile were included...
July 14, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28692588/utilization-of-colonoscopy-and-colonoscopic-findings-among-individuals-aged-40-54-years-with-a-positive-family-history-of-colorectal-cancer-a-cross-sectional-study-in-general-practice
#5
Jasper Plath, Andrea Siebenhofer, Ulrike Haug, Insa Koné, Marlene Hechtner, Irina Blumenstein, Sylvia Schulz-Rothe, Ferdinand M Gerlach, Corina Guethlin
Guidelines recommend early colonoscopy for individuals with a positive family history of colorectal cancer (CRC), but little is known about the utilization of colonoscopy and the frequency of colorectal neoplasms among younger affected individuals in Germany. The aim of this study was to determine the utilization of colonoscopy and the frequency of colorectal neoplasms in this risk group. We conducted a cross-sectional study in a general practice setting. Patients aged 40-54 years with at least one first-degree relative with CRC were identified, counseled on their increased risk, and referred to colonoscopy if they decided to undergo this procedure...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28684656/association-of-striking-life-events-with-primary-breast-cancer-in-265-chinese-women-a-case-control-study
#6
Yan Lin, Shengsheng Wang, Xiaohui Zhang, Changjun Wang, Guangliang Shan, Yidong Zhou, Feng Mao, Jinghong Guan, Xin Huang, Ying Zhong, Qiang Sun
The current case-control study investigated the relationship between striking life events and breast cancer in Chinese women. A total of 265 primary breast cancer patients and 265 controls were enrolled with matching for age and completed questionnaires. Logistic regression analysis was used. Thirty-nine breast cancer patients reported striking life events and twenty-four of the controls reported striking life events. The number of striking life events was significantly greater in patients (p = 0.04). It indicated a striking life event led to a 1...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28676593/the-relationship-between-food-insecurity-and-esophageal-and-gastric-cancers-a-case-control-study
#7
Milad Daneshi-Maskooni, Mahtab Badri-Fariman, Nahal Habibi, Ahmadreza Dorosty-Motlagh, Hashem Yavari, Arvin Kashani, Mostafa Hosseini
BACKGROUND: Food insecurity is defined as the limited or uncertain availability of enough food for permanent active and healthy life. Upper gastrointestinal (GI) cancers (esophagus and stomach) are one of five most common cancers in Iran. This study aimed to determine the association of food insecurity and upper GI cancers in newly diagnosed patients. STUDY DESIGN: Case-control study. METHODS: Overall, 120 patients with upper GI cancers as cases and 120 patients with orthopedic, ear-nose-throat (ENT), and neurologic diseases as controls were recruited from Imam Khomeini Hospital, Tehran, Iran in 2013...
June 14, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28674754/issues-related-to-family-history-of-cancer-at-the-end-of-life-a-palliative-care-providers-survey
#8
Catherine Gonthier, Sylvie Pelletier, Pierre Gagnon, Ana Marin, Jocelyne Chiquette, Bruno Gagnon, Louis Roy, Jude Emmanuel Cléophat, Yann Joly, Michel Dorval
Addressing the concerns of end-of-life patients or their relatives about their family history of cancer could benefit patients and family members. Little is known about how palliative care providers respond to these concerns. The purpose of this pilot study was to assess palliative care providers' knowledge about familial and hereditary cancers and explore their exposure to patients' and relatives' concerns about their family history of cancer, and their self-perceived ability to deal with such concerns. A cross-sectional survey was conducted in the Quebec City (Canada) catchment area among palliative care professionals...
July 3, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28670880/awareness-about-breast-cancer-and-its-screening-among-rural-egyptian-women-minia-district-a-population-based-study
#9
Ebtesam Esmail Hassan, Amany Edward Seedhom, Eman Mohamed Mahfouz
Background: Recent global cancer statistics indicate rising global incidence of breast cancer and the increase is occurring at a faster rate in developing countries. Training women how to carry out breast self-examination (BSE) can help them to be alert to any abnormalities in their breasts to speedily seek medical consultation. Health behavior may be influenced by level of awareness about breast cancer. Methods: A cross-sectional community- based study aimed to assess the level of knowledge about breast cancer risk factors, early warning signs, screening approaches and related predictors...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28669376/association-between-pancreatic-cancer-patients-perception-of-their-care-coordination-and-patient-reported-and-survival-outcomes
#10
Vanessa L Beesley, Monika Janda, Elizabeth A Burmeister, David Goldstein, Helen Gooden, Neil D Merrett, Dianne L O'Connell, David K Wyld, Raymond J Chan, Jane M Young, Rachel E Neale
OBJECTIVE: People with pancreatic cancer have poor survival, and management is challenging. Pancreatic cancer patients' perceptions of their care coordination and its association with their outcomes have not been well-studied. Our objective was to determine if perception of care coordination is associated with patient-reported outcomes or survival. METHODS: People with pancreatic cancer who were 1-8 months postdiagnosis (52 with completed resection and 58 with no resection) completed a patient-reported questionnaire that assessed their perceptions of care coordination, quality of life, anxiety, and depression using validated instruments...
July 3, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28627002/does-personalised-melanoma-genomic-risk-information-trigger-conversations-about-skin-cancer-prevention-and-skin-examination-with-family-friends-and-health-professionals
#11
A K Smit, L A Keogh, A J Newson, P N Butow, K Dunlop, R L Morton, J Kirk, D Espinoza, A E Cust
BACKGROUND: Receiving information about melanoma genomic risk might trigger conversations about skin cancer prevention and skin examinations. OBJECTIVES: To explore conversations prompted by receiving personalised genomic risk of melanoma with family, friends and health professionals. METHODS: We used a mixed-methods approach. Participants without a personal history and unselected for a family history of melanoma (n=103, aged 21-69, 53% women) completed questionnaires 3-months after receiving a personalised melanoma genomic risk assessment...
June 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28619403/practice-knowledge-and-barriers-for-screening-of-hepatocellular-carcinoma-among-high-risk-chinese-patients
#12
Kerui Xu, Shinobu Watanabe-Galloway, Fedja A Rochling, Jianjun Zhang, Paraskevi A Farazi, Hongyan Peng, Hongmei Wang, Jiangtao Luo
BACKGROUND: Hepatocellular carcinoma (HCC) is among the leading causes of cancer deaths in China. Considering its poor prognosis when diagnosed late, Chinese guidelines recommend biannual screening for HCC with abdominal ultrasound and serum α-fetoprotein (AFP) test for high-risk populations. OBJECTIVES: To investigate the practice, knowledge, and self-perceived barriers for HCC screening among high-risk hospital patients in China. METHODS: An interview-based questionnaire was conducted among Chinese patients with chronic hepatitis B and/or chronic hepatitis C infection from outpatient clinics at 2 tertiary medical institutions in Shanghai and Wuhan, China...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28603643/assessing-the-usefulness-and-acceptability-of-a-low-health-literacy-online-decision-aid-about-reproductive-choices-for-younger-women-with-breast-cancer-the-alliance-pilot-study-protocol
#13
Michelle Peate, Sian Karen Smith, Victoria Pye, Alice Hucker, Catharyn Stern, Lesley Stafford, Catherine Oakman, Laura Chin-Lenn, Kerry Shanahan, Nipuni Ratnayake Gamage, Martha Hickey
BACKGROUND: Young women diagnosed with breast cancer may be confronted by many difficult decisions, especially around fertility preservation prior to commencing cancer treatment. The information to be conveyed is complex, and it may be difficult to weigh up the risks and benefits of the different fertility preservation options available. This complexity is compounded by the widespread low levels of literacy and health literacy in Australia, which may result in greater difficulties in understanding available health information and in decision-making...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28596921/practices-of-breast-self-examination-and-associated-factors-among-female-debre-berhan-university-students
#14
Kalayu Birhane, Miskir Alemayehu, Belayneh Anawte, Gebru Gebremariyam, Ruth Daniel, Semeneh Addis, Teshome Worke, Abdurrahman Mohammed, Wassie Negash
BACKGROUND: Breast cancer is the most prevalent form of cancer in Ethiopia of all female cancers. It is considered to be a progressive disease with a poor prognosis if detected late. Breast self-examination is an important prevention method of breast cancer. This study was aimed at assessing practice and associated factors of breast self-examination (BSE) among female Debre Berhan University students in Ethiopia. METHODS: A cross-sectional study was conducted in 2015 among 420 using self-administrated questionnaire...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28578598/hyperthyroidism-hypothyroidism-and-cause-specific-mortality-in-a-large-cohort-of-women
#15
Neige M Y Journy, Marie-Odile Bernier, Michele M Doody, Bruce H Alexander, Martha S Linet, Cari M Kitahara
BACKGROUND: The prevalence of hyperthyroidism and hypothyroidism is 0.5-4% in iodine-replete communities, but it is 5-10 times higher in women than in men. Those conditions are associated with a broad range of metabolic disorders and cardiovascular diseases. Biological evidence of a role of thyroid hormones in carcinogenesis also exists. However, the association between thyroid dysfunction and cardiovascular disease or cancer mortality risk remains controversial. In a large cohort of women, the associations of hyperthyroidism and hypothyroidism with cause-specific mortality were evaluated after nearly 30 years of follow-up...
July 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28566532/risk-and-protective-factors-for-the-occurrence-of-sporadic-pancreatic-endocrine-neoplasms
#16
Roberto Valente, Alastair J Hayes, Sven-Petter Haugvik, Per Hedenström, Darko Siuka, Emilie Korsæth, Daniel Kaemmerer, Stuart Michael Robinson, Patrick Maisonneuve, Gianfranco Delle Fave, Bjorn Lindkvist, Gabriele Capurso
Pancreatic neuroendocrine neoplasms (PNENs) represent 10% of all pancreatic tumors by prevalence. Their incidence has reportedly increased over recent decades in parallel with that of pancreatic adenocarcinoma. PNENs are relatively rare and of the few institutions that have published potential risk factors, findings have been heterogenous. AIM: To investigate the association between potential risk and protective factors for the occurrence of sporadic PNENs across a European population from several institutions...
May 31, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28556580/a-family-history-questionnaire-sent-to-patients-prior-to-colonoscopy-enhances-genetic-counseling-for-hereditary-colorectal-cancer
#17
Koen Kessels, Joey D Eisinger, Tom G Letteboer, G Johan A Offerhaus, Peter D Siersema, Leon M G Moons
AIM: We investigated whether sending a family history questionnaire (FHQ) to patients prior to undergoing colonoscopy results in an increase of an available family history and genetic counseling. METHODS: A FHQ was sent by mail to patients before undergoing outpatient colonoscopy at a university hospital in 2013. Additional characteristics and referral for genetic evaluation of patients undergoing colonoscopy in 2013 were retrieved from the electronic medical record (EMR)...
May 29, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28520842/alcohol-consumption-and-breast-cancer-risk-by-family-history-of-breast-cancer-and-folate-intake-in-younger-women
#18
Hyun Ja Kim, Seungyoun Jung, A Heather Eliassen, Wendy Y Chen, Walter C Willett, Eunyoung Cho
To evaluate the association between alcohol consumption and breast cancer risk in younger women, and by family history of breast cancer and folate intake, we prospectively followed 93,835 U.S. women aged 27-44 years with alcohol consumption data in 1991 in the Nurses' Health Study II. Alcohol and folate intake was measured by food frequency questionnaire repeated every 4 years. We documented 2,866 incident invasive breast cancer cases between 1991 and 2011. Alcohol consumption was not associated with breast cancer risk overall (multivariate hazard ratio = 1...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28498247/practice-patterns-of-hereditary-ovarian-cancer-management-in-korea
#19
Min Chul Choi, Myong Cheol Lim, Maria Lee, Min Kyu Kim, Dong Hoon Suh, Yong Jung Song, Tae-Joong Kim, Suk-Joon Chang, Jae-Weon Kim
OBJECTIVE: This study aims to evaluate practice patterns for managing hereditary ovarian cancer among Korean gynecologic oncologic physicians. METHODS: Members of the Korean Society of Gynecologic Oncology participated in the inaugural Hereditary Gynecologic Cancer Symposium or were invited to this survey by e-mail from January to February 2016. The survey was conducted using a self-administered questionnaire. RESULTS: Most physicians (66...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28482828/health-beliefs-illness-perceptions-and-determinants-of-breast-screening-uptake-in-malta-a-cross-sectional-survey
#20
Danika Marmarà, Vincent Marmarà, Gill Hubbard
BACKGROUND: Women's beliefs and representations of breast cancer (BC) and breast screening (BS) are salient predictors for BS practices. This study utilized the health belief model (HBM) and common-sense model (CSM) of illness self-regulation to explore factors associated with BS uptake in Malta and subsequently, to identify the most important predictors to first screening uptake. METHODS: This cross-sectional survey enrolled Maltese women (n = 404) ages 50 to 60 at the time of their first screening invitation, invited to the National Breast Screening Programme by stratified random sampling, with no personal history of BC...
May 8, 2017: BMC Public Health
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