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L Gao, S-S Xu, J-Q Yang, M Shen, M-H Li
Variations in ear size can be observed in livestock such as sheep; however, the genetic basis of variable ear size in sheep is still poorly understood. To investigate causative genes associated with ear size in sheep, a genome-wide association study was performed in 115 adult Duolang sheep with different-sized floppy ears using the Ovine Infinium HD BeadChip. We found 38 significant SNPs at the genome-wide or chromosome-wise 5% significance level after Bonferroni correction. The most significant association (P = 1...
May 18, 2018: Animal Genetics
Katia Le Barbu-Debus, Arne Scherrer, Aude Bouchet, Daniel Sebastiani, Rodolphe Vuilleumier, Anne Zehnacker
The influence of flexibility and hydrogen bond formation on the IR absorption and vibrational circular dichroism (VCD) spectrum of a floppy protic molecule, namely, (S)-1-indanol, is studied in both non-polar CCl4 and polar DMSO solvents. The experimental IR absorption and VCD spectra obtained by Fourier transform spectroscopy are interpreted using both static density functional theory (DFT) calculations and first principles molecular dynamics (FPMD) within DFT, using the nuclear velocity perturbation theory (NVPT)...
May 17, 2018: Physical Chemistry Chemical Physics: PCCP
Raffaele Nuzzi, Paolo Arnoffi, Federico Tridico
Background: Intraoperative Floppy Iris Syndrome (IFIS) is an important cause of surgical complications and iris defects in patients undergoing phacoemulsification that were treated with selective subtype α1A receptor antagonists for a long period of time. To date, no definitive preventive strategy has emerged, yet. The need of prophylaxis is dictated by the high prevalence of males affected by benign prostatic hyperplasia undergoing cataract surgery. Objective: To identify the best prophylactic strategy in groups at risk of IFIS development by comparing two mydriatic treatments in course of phacoemulsification surgery...
2018: Open Ophthalmology Journal
Akira Takada, Kathryn J Glaser, Robert G Bell, C Richard A Catlow
Structural changes in tridymite have been investigated by molecular dynamics simulation. Two thermal processes were carried out, one cooling from the high-temperature hexagonal structure of tridymite (HP-tridymite) and the other heating from the low-temperature monoclinic structure of tridymite (MX1-tridymite). The former process showed that HP, LHP (low-temperature hexagonal structure), OC (orthorhombic structure with C 2221 symmetry) and OP (orthorhombic structure with P 21 21 21 symmetry)-like structures appeared in sequence...
May 1, 2018: IUCrJ
Andreas Lunacek, Badereddin Mohamad Al-Ali, Christian Radmayr, Maria Weber, Wolfgang Horninger, Oliver Findl, Eugen Plas
Introduction: The use of alpha-1 receptor antagonists in the treatment of benign prostatic hyperplasia (BPH) has created a problem in ophthalmic surgery, the so-called intraoperative floppy iris syndrome (IFIS). This consists of a billowing iris, insufficient pupillary dilation with progressive intraoperative miosis, and protrusion of iris tissue through the tunnel and side port incision that are made for access to the anterior chamber during surgery. IFIS presents particular difficulties in cataract surgery which is carried out through the pupil with manipulations in the immediate vicinity of the iris...
2018: Central European Journal of Urology
Reese Jones, Jessica M Rimsza, Louise J Criscenti
Using an atomistic technique consistent with continuum balance laws and drawing on classical fracture mechanics theory, we estimate the resistance to fracture propa- gation of amorphous silica. We discuss correspondence and deviations from classical linear elastic fracture mechanics theory including size dependence, rigid/floppy modes of deformation, and the effects of surface energy and stress.
May 4, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Niraj Kumar Dipak, Shilpa Pandya, Omkar Hajirnis, Baliram Pandurang Munde
No abstract text is available yet for this article.
April 27, 2018: Archives of Disease in Childhood. Education and Practice Edition
Fehim Esen, Azer Erdagi Bulut, Ebru Toker
PURPOSE: The aim of this study was to evaluate the efficacy and safety of topical atropine and topical atropine combined with intracameral low-concentration, bisulfite-containing epinephrine treatment for the prophylaxis of intraoperative floppy iris syndrome. MATERIAL AND METHODS: Seventy-two eyes of 55 male patients who were treated with alpha-adrenergic antagonist medications for benign prostatic hyperplasia were included in this study. Standard premedication with topical cyclopentolate, phenylephrine, tropicamide and ketorolac was applied to all of the patients...
April 2, 2018: Cutaneous and Ocular Toxicology
Erica Corredera, Kara S Davis, Jeffrey P Simons, Noel Jabbour
OBJECTIVE: The goal of this study is to measure the quality and readability of websites related to laryngomalacia, and to compare the quality and readability scores for the sites accessed through the most popular search engines. INTRODUCTION: Laryngomalacia is a common diagnosis in children but is often difficult for parents to comprehend. As information available on the internet is unregulated, the quality and readability of this information may vary. METHODS: An advanced search on Google, Yahoo, and Bing was conducted using the terms "laryngomalacia" OR "soft larynx" OR "floppy voice box...
May 2018: International Journal of Pediatric Otorhinolaryngology
John P Richard, Tina L Amyes, Archie C Reyes
The mystery associated with catalysis by what were once regarded as protein black boxes, diminished with the X-ray crystallographic determination of the three-dimensional structures of enzyme-substrate complexes. The report that several high-resolution X-ray crystal structures of orotidine 5'-monophosphate decarboxylase (OMPDC) failed to provide a consensus mechanism for enzyme-catalyzed decarboxylation of OMP to form uridine 5'-monophosphate, therefore, provoked a flurry of controversy. This controversy was fueled by the enormous 1023 -fold rate acceleration for this enzyme, which had " jolted many biochemists' assumptions about the catalytic potential of enzymes...
March 29, 2018: Accounts of Chemical Research
Zhiqiang Lin, Kanglun Jiang, Lin Zhao, Shuna Li, Shu Shao, Wei Qian, Zezhang Tao
OBJECTIVES/HYPOTHESIS: To evaluate changes in pharyngeal wall floppiness (PWF) between patients with obstructive sleep apnea-hypopnea syndrome induced by non-upper-airway structural factors and normal subjects, as well as the clinical significance using acoustic pharyngealmetry technology. STUDY DESIGN: Cohort study. METHODS: The obstructive sleep apnea (OSA) group (n = 102) and the normal control group (n = 50) were identified using the Eccovision Acoustic Pharyngometer measuring instrument...
March 23, 2018: Laryngoscope
Ilona A Kaczmarek, Marek E Prost, Jaromir Wasyluk
PURPOSE: To evaluate the incidence of and factors associated with intraoperative floppy iris syndrome (IFIS) in patients undergoing cataract phacoemulsification. METHODS: In total, 319 eyes of 319 patients who underwent phacoemulsification with implantation of an intraocular lens (IOL) into the posterior chamber were included in this study. Direct injection of epinephrine into the anterior chamber was performed in all cases. The following patient information was collected: gender, age, axial length of the eye, presence of pseudoexfoliation syndrome, glaucoma, diabetes mellitus, hypertension, current use of medications including alpha1 adrenergic receptor antagonists (alpha1-ARAs), finasteride, and benzodiazepines, duration of intake of alpha1-ARAs and finasteride, and duration of the surgery...
March 17, 2018: International Ophthalmology
Subramaniyan Ramanathan, Michele Bertolotto, Ahmad Shamsodini, Mahmoud Heidous, Vikram Dogra, Parvati Ramchandani
OBJECTIVE: The objective of our article is to review the role of imaging in the diagnosis of various complications of a penile prosthesis (PP). CONCLUSION: Complications of a PP can be categorized into three groups: first, malpositioning, which includes buckling, floppy glans, erosion, migration, and crossover; second, mechanical failure, which includes fracture, aneurysm, and leakage; and, third, infection. Radiography, sonography, CT, and MRI are useful in the detection of these complications and complement each other, with MRI being the most useful imaging modality among them...
March 12, 2018: AJR. American Journal of Roentgenology
Salvatore Cillino, Aissa Iggui, Simona Di Naro, Giovanni Cillino, Domenica Matranga, Walter Mazzucco, Fanny Pojero, Alessandra Casuccio
PURPOSE: To analyze the frequency of inappropriate hospitalization in cataract surgery and the type of related determinants. METHODS: A nested retrospective case-control study was carried out on 2708 consecutive cataract surgery patients operated between January 2013 and December 2015. All cases with inappropriate hospitalization (day surgery or ordinary hospitalization) were compared with a control group of cases treated in an appropriate (day service) regimen...
March 8, 2018: International Ophthalmology
Di Zhou, Leyou Zhang, Xiaoming Mao
Disordered fiber networks are ubiquitous in a broad range of natural (e.g., cytoskeleton) and manmade (e.g., aerogels) materials. In this Letter, we discuss the emergence of topological floppy edge modes in two-dimensional fiber networks as a result of deformation or active driving. It is known that a network of straight fibers exhibits bulk floppy modes which only bend the fibers without stretching them. We find that, interestingly, with a perturbation in geometry, these bulk modes evolve into edge modes. We introduce a topological index for these edge modes and discuss their implications in biology...
February 9, 2018: Physical Review Letters
Shohei Okazaki, Takanori Abe, Natsuko Takayanagi, Masanori Yasuda, Fumikazu Sakai, Kunihiko Kobayashi, Shingo Kato
BACKGROUND/AIM: We report on a case of pulmonary tumor embolism caused by squamous cell carcinoma of the uterine cervix. PATIENTS AND METHODS: A 60-year-old female diagnosed with stage IVB (cT4N1M1) squamous cell carcinoma of the uterine cervix was admitted to our institution with a chief complaint of progressive dyspnea that developed within a few days after admission. RESULTS: A chest CT scan showed dilated pulmonary arteries, right ventricular enlargement and mosaic ground-glass opacities in both lungs...
March 2018: In Vivo
Ying-Ying Gao, Hong-Juan Wang, You Wu
BACKGROUND: Known causes of superficial punctuate keratopathy (SPK) in children include entropion, viral infection, blepharokeratoconjunctivitis (BKC), and toxicity of eye drops. However, there are some SPK patients whose causes could not be identified well. Herein, we describe the history, diagnosis, treatment, and prognosis of a rare case. CASE PRESENTATION: To report a case of superficial punctate keratopathy (SPK) which coexisted with floppy eyelid syndrome (FES) and presented as intermittent red eye and blurred vision in an 11-year-old boy who slept in the prone position...
February 23, 2018: BMC Ophthalmology
Petrus S S Castelijns, Marcel C G van de Poll, Johannes F Smulders
INTRODUCTION: Nissen fundoplication is frequently applied in the surgical treatment of patients with gastroesophageal reflux disease (GERD). When the gastroesophageal junction remains too large or becomes too narrow, persistent GERD or dysphagia may occur. To assure a correct size of the gastroesophageal junction, the fundoplication can be created over a bougie. However, this increases the risk of esophageal perforation. Therefore, we have modified a previously described technique to create a standardized fundoplication without the use of a bougie...
February 21, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Ahmed Adam
Objective: To describe a simple, novel method to achieve ureteric access in the Cohen crossed reimplanted ureter, which will allow retrograde working access via the conventional transurethral method. Materials and Methods: Under cystoscopic vision, suprapubic needle puncture was performed. The needle was directed (bevel facing) towards the desired ureteric orifice (UO). A guidewire (with a floppy-tip) was then inserted into the suprapubic needle passing into the bladder, and then easily passed into the crossed-reimplanted UO...
November 2017: Current Urology
Kaveh Vahdani, Rebecca Ford, Helen Garrott, Vladimir Theodor Thaller
OBJECTIVES: To compare the functional and anatomical outcomes of lateral tarsal strip (LTS) with Bick's procedure in treatment of eyelid malposition. METHODS: A retrospective, consecutive case series of patients who underwent LTS and Bick's procedure for all types of involutional lower eyelid malposition, at two centers between January 2012 and 2015. Statistical analyses of differences between groups were performed using the Fisher's exact test to compare non-continuous variables and Mann-Whitney U test for continuous variables...
February 21, 2018: Eye
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