Marika Pane, Giulia Stanca, Chiara Ticci, Costanza Cutrona, Roberto De Sanctis, Matteo Pirinu, Giorgia Coratti, Concetta Palermo, Beatrice Berti, Daniela Leone, Michele Sacchini, Margherita Cerboneschi, Lavinia Fanelli, Giulia Norcia, Nicola Forcina, Anna Capasso, Gianpaolo Cicala, Laura Antonaci, Martina Ricci, Maria Carmela Pera, Chiara Bravetti, Maria Alice Donati, Elena Procopio, Emanuela Abiusi, Alessandro Vaisfeld, Roberta Onesimo, Francesco Danilo Tiziano, Eugenio Mercuri
Neonatal screening for SMA has allowed the identification of infants who may present with early clinical signs. Our aim was to establish whether the presence and the severity of early clinical signs have an effect on the development of motor milestones. Infants identified through newborn screening were prospectively assessed using a structured neonatal neurological examination and an additional module developed for the assessment of floppy infants. As part of the follow-up, all infants were assessed using the HINE-2 to establish developmental milestones...
April 18, 2024: European Journal of Pediatrics