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https://www.readbyqxmd.com/read/28093089/atrial-septal-defect-with-right-to-left-shunt-in-the-absence-of-pulmonary-hypertension
#1
Devi A Manuel, Gopal C Ghosh, Anoop G Alex
We describe the case of a 27-year-old gentleman who developed late-onset clubbing and cyanosis. Transoesophageal echocardiography revealed a 27-mm ostium secundum atrial septal defect and a large, floppy Eustachian valve directing right atrial blood to the left side of the heart.
January 17, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28003734/debs-a-unification-theory-for-dry-eye-and-blepharitis
#2
James M Rynerson, Henry D Perry
For many years, blepharitis and dry eye disease have been thought to be two distinct diseases, and evaporative dry eye distinct from aqueous insufficiency. In this treatise, we propose a new way of looking at dry eye, both evaporative and insufficiency, as the natural sequelae of decades of chronic blepharitis. Dry eye is simply the late form and late manifestation of one disease, blepharitis. We suggest the use of a new term in describing this one chronic disease, namely dry eye blepharitis syndrome (DEBS)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28000820/stability-of-2-3-and-3-5-cyclic-nucleotides-in-formamide-and-in-water-a-theoretical-insight-into-the-factors-controlling-the-accumulation-of-nucleic-acid-building-blocks-in-a-prebiotic-pool
#3
Giuseppe Cassone, Jiří Šponer, Franz Saija, Ernesto Di Mauro, A Marco Saitta, Judit E Šponer
Synthesis of the first RNAs represents one of the cornerstones of the emergence of life. Recent studies demonstrated powerful scenarios of prebiotic synthesis of cyclic nucleotides in aqueous and formamide environments. This raised a question about their thermodynamic stability, a decisive factor determining their accumulation in a prebiotic pool. Here we performed ab initio molecular dynamics simulations at various temperatures in formamide and water to study the relative stabilities of the 2',3' and 3',5' isomers of cyclic nucleotides...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27999697/modified-surgical-techniques-for-managing-intraoperative-floppy-iris-syndrome
#4
Pornchai Simaroj, Kaevalin Lekhanont, Puwat Charukamnoetkanok
Purpose. To report a modified surgical strategy in the management of intraoperative floppy iris syndrome-associated iris prolapse. Methods. Prolapsed iris is left as is and a new corneal incision near the original wound but at a different site is created. Depending on the location of the original incision and the surgeon's preference, this additional incision can be used as a new port for phacoemulsification tip or can be the new site for the iris to securely prolapse, allowing for the surgery to proceed safely...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27910450/first-order-reversal-curves-forc-analysis-of-individual-magnetic-nanostructures-using-micro-hall-magnetometry
#5
Merlin Pohlit, Paul Eibisch, Maryam Akbari, Fabrizio Porrati, Michael Huth, Jens Müller
Alongside the development of artificially created magnetic nanostructures, micro-Hall magnetometry has proven to be a versatile tool to obtain high-resolution hysteresis loop data and access dynamical properties. Here we explore the application of First Order Reversal Curves (FORC)-a technique well-established in the field of paleomagnetism for studying grain-size and interaction effects in magnetic rocks-to individual and dipolar-coupled arrays of magnetic nanostructures using micro-Hall sensors. A proof-of-principle experiment performed on a macroscopic piece of a floppy disk as a reference sample well known in the literature demonstrates that the FORC diagrams obtained by magnetic stray field measurements using home-built magnetometers are in good agreement with magnetization data obtained by a commercial vibrating sample magnetometer...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27878578/the-double-guidewire-approach-for-transcoronary-pacing-in-a%C3%A2-porcine-model
#6
K M Heinroth, S Unverzagt, D Mahnkopf, S Frantz, R Prondzinsky
BACKGROUND: Transcoronary pacing is used for treatment of unheralded bradycardias in the setting of percutaneous coronary interventions (PCI). OBJECTIVES: In the present study we introduced a new concept - the double guidewire approach - for transcoronary pacing in a porcine model. METHODS: Transcoronary pacing was applied in 16 adult pigs under general anaesthesia in an animal catheterization laboratory. A special guidewire with electrical insulation by PTFE coating except for the distal part of the guidewire was positioned in the periphery of a coronary artery serving as the cathode...
November 23, 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/27872024/floppy-glans-syndrome-pathogenesis-and-treatment
#7
REVIEW
Michael Bickell, Neil Manimala, Justin Parker, Brian Steixner, Lucas Wiegand, Rafael Carrion
INTRODUCTION: Floppy glans syndrome (FGS) is a potential complication of penile prosthesis placement in patients with erectile dysfunction. FGS affects a very small proportion of these patients, and it can manifest in a ventral, dorsal, or lateral droop of a hypermobile glans, which can cause affected patients to complain of painful, unsatisfying, or otherwise difficult attempts at sexual intercourse. Incorrect cylinder sizing can even result in extreme conditions such as flail penis or S-shaped deformity...
April 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27811633/wingtip-flap-for-reconstruction-of-full-thickness-upper-and-lower-eyelid-defects
#8
Ivan Vrcek, Eva Chou, Sean Blaydon, John Shore
PURPOSE: Pentagonal wedge resection is a technique used to address a wide variety of eyelid pathology. This procedure frequently results in excess skin at the apex of the wound, commonly known as a "dog ear." A variety of methods have been described to address the cutaneous redundancy, the most classic of which is the Burow's triangle repair. The authors present a technique to address the anterior lamellar excess that avoids placement of a vertical scar traversing the pretarsal and preseptal portion of the affected eyelid...
November 2, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27811562/outcomes-of-descemet-stripping-automated-endothelial-keratoplasty-in-toxic-anterior-segment-syndrome-after-phacoemulsification
#9
Manpreet Kaur, Jeewan S Titiyal, Ruchita Falera, Tarun Arora, Namrata Sharma
PURPOSE: To evaluate the visual and anatomical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with toxic anterior segment syndrome (TASS). METHODS: Fourteen eyes of 14 patients who underwent clear corneal DSAEK for endothelial decompensation secondary to TASS after phacoemulsification were included in this prospective study. Intraoperative surgical difficulties were noted. Preoperative and postoperative evaluation of visual acuity, slit-lamp examination, intraocular pressure, central corneal thickness, and endothelial count was performed in all cases...
January 2017: Cornea
https://www.readbyqxmd.com/read/27761703/intraoperative-floppy-iris-syndrome-and-its-association-with-various-concurrent-medications-bulbus-length-patient-age-and-gender
#10
Michael Wahl, Saskia M Tipotsch-Maca, Pia V Vecsei-Marlovits
PURPOSE: To evaluate the association between intraoperative floppy iris syndrome (IFIS) and concurrent medications containing selective alpha1A receptor antagonists as well as nonselective alpha1-adrenergic receptor antagonists, bulbus length, patient age and gender. METHODS: We performed a prospective data acquisition of IFIS occurrence and grading, and retrospective evaluation of concurrent medications, bulbus length, patient age and gender of all patients undergoing cataract surgery over a 6-month period...
January 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27740787/neurofilaments-function-as-shock-absorbers-compression-response-arising-from-disordered-proteins
#11
Micha Kornreich, Eti Malka-Gibor, Ben Zuker, Adi Laser-Azogui, Roy Beck
What can cells gain by using disordered, rather than folded, proteins in the architecture of their skeleton? Disordered proteins take multiple coexisting conformations, and often contain segments which act as random-walk-shaped polymers. Using x-ray scattering we measure the compression response of disordered protein hydrogels, which are the main stress-responsive component of neuron cells. We find that at high compression their mechanics are dominated by gaslike steric and ionic repulsions. At low compression, specific attractive interactions dominate...
September 30, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27704483/slackline-training-balancing-over-narrow-nylon-ribbons-and-balance-performance-a-meta-analytical-review
#12
Lars Donath, Ralf Roth, Lukas Zahner, Oliver Faude
BACKGROUND: Adequate static and dynamic balance performance is an important prerequisite during daily and sporting life. Various traditional and innovative balance training concepts have been suggested to improve postural control or neuromuscular fall risk profiles over recent years. Whether slackline training (balancing over narrow nylon ribbons) serves as an appropriate training strategy to improve static and dynamic balance performance is as yet unclear. OBJECTIVE: The aim was to examine the occurrence and magnitude of effects of slackline training compared with an inactive control condition on static and dynamic balance performance parameters in children, adults and seniors...
October 4, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27704220/a-review-of-the-safety-of-clozapine-during-pregnancy-and-lactation
#13
REVIEW
Taylor M Mehta, Ryan J Van Lieshout
Clozapine is an antipsychotic used in the management of treatment-resistant schizophrenia. However, little is known about clozapine use during pregnancy and lactation, or its impact on the mother, foetus, and infant. This review aims to summarize the available literature on the safety of clozapine use during the perinatal period. EMBASE, PsycINFO, and MEDLINE were searched from their inceptions through June 2016. The review encompasses 21 studies that have examined clozapine use during pregnancy and lactation...
October 4, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27659790/abdominal-pain-due-to-a-wandering-liver
#14
Antoine Bruneau, Giovanni Battista Levi Sandri, Michel Rayar, Laurent Sulpice, Karim Boudjema
Wandering liver syndrome is an extremely rare congenital disorder. It is mainly diagnosed within the first years of life. Herein we report the case of a 40-year-old woman with hepatoptosis due to the absence of anatomical peritoneal attachments of the liver. Surgical treatment consisted in inserting the floppy right lobe of the liver in a subphrenic retroperitoneal pouch. This original technique provided excellent postoperative result.
September 22, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27635626/eye-disorders-associated-with-obstructive-sleep-apnoea
#15
Sophie D West, Chris Turnbull
PURPOSE OF REVIEW: Obstructive sleep apnoea (OSA) is increasing in prevalence due to rising obesity. Public awareness is also growing. Although OSA is a disorder primarily of the upper airway during sleep, its physiological impact on other parts of the body is now well recognized. There is increasing interest in the association of OSA with various eye disorders. Work in this field has been directed predominantly to OSA prevalence and association studies, but some authors have tried to elucidate the effect of OSA therapies on eye diseases, including continuous positive airway pressure, upper airway surgery or bariatric surgery...
November 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27621463/the-role-of-rigidity-in-controlling-material-failure
#16
Michelle M Driscoll, Bryan Gin-Ge Chen, Thomas H Beuman, Stephan Ulrich, Sidney R Nagel, Vincenzo Vitelli
We investigate how material rigidity acts as a key control parameter for the failure of solids under stress. In both experiments and simulations, we demonstrate that material failure can be continuously tuned by varying the underlying rigidity of the material while holding the amount of disorder constant. As the rigidity transition is approached, failure due to the application of uniaxial stress evolves from brittle cracking to system-spanning diffuse breaking. This evolution in failure behavior can be parameterized by the width of the crack...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27570388/congenital-muscular-dystrophy-with-inflammation-diagnostic-considerations
#17
Kaumudi Konkay, Meena Angamuthu Kannan, Lokesh Lingappa, Megha S Uppin, Sundaram Challa
BACKGROUND AND PURPOSE: Muscle biopsy features of congenital muscular dystrophies (CMD) vary from usual dystrophic picture to normal or nonspecific myopathic picture or prominent fibrosis or striking inflammatory infiltrate, which may lead to diagnostic errors. A series of patients of CMD with significant inflammatory infiltrates on muscle biopsy were correlated with laminin α2 deficiency on immunohistochemistry (IHC). MATERIAL AND METHODS: Cryostat sections of muscle biopsies from the patients diagnosed as CMD on clinical and muscle biopsy features from 1996 to 2014 were reviewed with hematoxylin and eosin(H&E), enzyme and immunohistochemistry (IHC) with laminin α2...
July 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27531288/untoward-events-associated-with-aberrant-fluid-infusion-during-cataract-surgery-laboratory-study-with-corroborative-clinical%C3%A2-observations
#18
Richard S Koplin, David C Ritterband, Jack M Dodick, Eric D Donnenfeld, Mark Schafer
PURPOSE: To determine the relationship between untoward events noted during phacoemulsification surgery associated with aberrant infusion misdirection and their causal relationship to current infusion sleeve design. SETTING: The New York Eye & Ear Infirmary of Mt. Sinai, New York, New York, USA. DESIGN: Retrospective case reports and experimental study. METHODS: Observations of live cataract surgery were documented with high-definition videography using 3 commercial phacoemulsification platforms...
August 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27521670/intraoperative-floppy-iris-syndrome-associated-with-use-of-antipsychotic-drugs
#19
Masato Matsuo, Ichiya Sano, Yoshifumi Ikeda, Etsuko Fujihara, Masaki Tanito
OBJECTIVE: We report 3 cases of intraoperative floppy-iris syndrome (IFIS) during cataract surgery in patients without a history of selective α1-blocker use but with a long-term history of antipsychotic drug use. We reviewed previously reported cases of antipsychotic drug-associated IFIS cases. DESIGN: Observational case series. RESULTS: In case 1, bilateral IFIS developed in a 39-year-old man with chronic angle-closure glaucoma. He had used several classes of antipsychotic drugs to treat schizophrenia, including the first-generation antipsychotic drugs haloperidol and chlorpromazine, the dopamine system stabilizer aripiprazole, the dopamine serotonin antagonists olanzapine and quetiapine, and the serotonin dopamine antagonists risperidone and blonanserin for 7 years...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27473881/chest-radiograph-as-diagnostic-clue-in-a-floppy-infant
#20
Isabella Schmeh, André Kidszun, Ekkehart Lausch, Oliver Bartsch, Eva Mildenberger
No abstract text is available yet for this article.
October 2016: Journal of Pediatrics
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