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Motor impairment in very preterm-born children

Katelyn Cahill-Rowley, Jessica Rose
Temporal-spatial reach parameters are revealing of upper-limb function in children with motor impairments, but have not been quantified in a toddler population. This work quantitatively characterizes temporal-spatial reach in typically-developing (TD) and very-low-birth-weight (VLBW) preterm toddlers, who are at increased risk of motor impairment. 47 children born VLBW (<1500 g birth-weight; ≤32 weeks gestation) and 22 TD children completed a reaching assessment at 18-22 months of age, adjusted for prematurity...
April 27, 2018: Journal of Biomechanics
Julia M Young, Marlee M Vandewouw, Benjamin R Morgan, Mary Lou Smith, John G Sled, Margot J Taylor
Children born very preterm (VPT) at less than 32 weeks' gestational age (GA) are prone to disrupted white matter maturation and impaired cognitive development. The aims of the present study were to identify differences in white matter microstructure and connectivity of children born VPT compared to term-born children, as well as relations between white matter measures with cognitive outcomes and early brain injury. Diffusion images and T1-weighted anatomical MR images were acquired along with developmental assessments in 31 VPT children (mean GA: 28...
January 29, 2018: Brain Structure & Function
Hilary S Wong, Frances M Cowan, Neena Modi
OBJECTIVE: To determine the validity of assessing and recording the neurodevelopmental outcome of very preterm infants during routine clinical follow-up in England. DESIGN: Children born <30 weeks gestation, attending routine clinical follow-up at post-term ages 20-28 months, were recruited. Data on neurodevelopmental outcomes were recorded by the reviewing clinician in a standardised format in the child's electronic patient record, based on a set of key questions designed to be used without formal training or developmental testing...
October 27, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
C Arberet, M Proisy, J L Fausser, M Curt, P Bétrémieux, C Tréguier, C Rozel, P Pladys
OBJECTIVE: To study the quality of life at school age of very preterm infants presenting isolated punctate periventricular white matter lesions (IPWL) on late-preterm or term magnetic resonance imaging (MRI). METHODS: In 1996-2000, 16 of the 131 very preterm neonates explored by MRI were found to have IPWL. At the age of 9-14, 12 children from the IPWL group were compared with 54 children born preterm but with a normal MRI (no lesion). Quality of life (Health Status Classification System Pre School questionnaire), school performance, and motor outcome were investigated...
2017: Journal of Neonatal-perinatal Medicine
Niklas Lenfeldt, Anna-Maria Johansson, Erik Domellöf, Katrine Riklund, Louise Rönnqvist
Altered white matter microstructure is commonly found in children born preterm (PT), especially those born at an extremely low gestational age (GA). These children also commonly show disturbed motor function. This study explores the relation between white matter alterations and upper-limb movement segmentation in 41 children born PT (19 girls), and 41 children born at term (18 girls) at 8 years. The PT group was subdivided into extremely PT (E-PT; GA = 25-27 weeks, N = 10), very PT (V-PT; GA = 28-32 weeks, N = 13), and moderately PT (M-PT; GA = 33-35 weeks, N = 18)...
July 7, 2017: Human Brain Mapping
Peter J Anderson, Karli Treyvaud, Jeffrey J Neil, Jeanie L Y Cheong, Rodney W Hunt, Deanne K Thompson, Katherine J Lee, Lex W Doyle, Terrie E Inder
OBJECTIVE: To determine the relationship between brain abnormalities on newborn magnetic resonance imaging (MRI) and neurodevelopmental impairment at 7 years of age in very preterm children. STUDY DESIGN: A total of 223 very preterm infants (<30 weeks of gestation or <1250 g) born at Melbourne's Royal Women's Hospital had a brain MRI scan at term equivalent age. Scans were scored using a standardized system that assessed structural abnormality of cerebral white matter, cortical gray matter, deep gray matter, and cerebellum...
August 2017: Journal of Pediatrics
J W Logan, O Dammann, E N Allred, C Dammann, K Beam, R M Joseph, T M O'Shea, A Leviton, K C K Kuban
OBJECTIVE: A neonatal illness severity score, The Score for Neonatal Acute Physiology-II (SNAP-II), predicts neurodevelopmental impairments at two years of age among children born extremely preterm. We sought to evaluate to what extent SNAP-II is predictive of cognitive and other neurodevelopmental impairments at 10 years of age. STUDY DESIGN: In a cohort of 874 children born before 28 weeks of gestation, we prospectively collected clinical, physiologic and laboratory data to calculate SNAP-II for each infant...
May 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
Anne Synnes, Thuy Mai Luu, Diane Moddemann, Paige Church, David Lee, Michael Vincer, Marilyn Ballantyne, Annette Majnemer, Dianne Creighton, Junmin Yang, Reginald Sauve, Saroj Saigal, Prakesh Shah, Shoo K Lee
OBJECTIVES: Identify determinants of neurodevelopmental outcome in preterm children. METHODS: Prospective national cohort study of children born between 2009 and 2011 at <29 weeks gestational age, admitted to one of 28 Canadian neonatal intensive care units and assessed at a Canadian Neonatal Follow-up Network site at 21 months corrected age for cerebral palsy (CP), visual, hearing and developmental status using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III)...
May 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
So Hyun Kim, Robert M Joseph, Jean A Frazier, Thomas M O'Shea, Katarzyna Chawarska, Elizabeth N Allred, Alan Leviton, Karl K Kuban
OBJECTIVE: To examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth. STUDY DESIGN: We examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT in predicting an ASD diagnosis at age 10 years based on gold standard diagnostic instruments...
November 2016: Journal of Pediatrics
Brian B Monson, Peter J Anderson, Lillian G Matthews, Jeffrey J Neil, Kush Kapur, Jeanie L Y Cheong, Lex W Doyle, Deanne K Thompson, Terrie E Inder
IMPORTANCE: Smaller cerebral volumes at hospital discharge in very preterm (VPT) infants are associated with poor neurobehavioral outcomes. Brain growth from the newborn period to middle childhood has not been explored because longitudinal data have been lacking. OBJECTIVES: To examine the pattern of growth of cerebral tissue volumes from hospital discharge to childhood in VPT infants and to determine perinatal risk factors for impaired brain growth and associations with neurobehavioral outcomes at 7 years...
August 1, 2016: JAMA Pediatrics
Maja Gilarska, Malgorzata Klimek, Magdalena Nitecka, Grażyna Dutkowska, Monika Gasinska, Przemko Kwinta
BACKGROUND: The aim of our study was multifaceted neurodevelopmental examination of children born prematurely with very low birth weight (VLBW) in order to evaluate the usefulness of popularly used tests. The second aim of the study was exploration of risk and protective factors of neurodevelopmental impairment. METHODS: Eighty-nine VLBW patients were evaluated at the age of 50 months. All children underwent anthropometric measurements and psychomotor tests: functional independence measure scale (WeeFIM), Gross Motor Function Measurement (GMFM), non-verbal psychometric evaluation (Leiter test), Developmental Test of Visual Perception (DTVP-2), temperament questionnaire (EAS-C) and children vocabulary test (TSD)...
June 8, 2016: Minerva Pediatrica
M A Matthews, J L Aschner, A R Stark, P E Moore, J C Slaughter, S Steele, A Beller, G L Milne, O Settles, O Chorna, N L Maitre
OBJECTIVE: This study examined the association between increased early oxidative stress, measured by F2-isoprostanes (IsoPs), and respiratory morbidity at term equivalent age and neurological impairment at 12 months of corrected age (CA). STUDY DESIGN: Plasma samples were collected from 136 premature infants on days 14 and 28 after birth. All participants were infants born at ⩽28 weeks of gestational age enrolled into the Prematurity and Respiratory Outcomes Program (PROP) study...
September 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Sirkku Setänen, Liisa Lehtonen, Riitta Parkkola, Jaakko Matomäki, Leena Haataja
BACKGROUND: Preterm infants are at a higher risk for poor motor outcome than term infants. This study aimed to describe the long-term motor profile in very preterm born children. METHODS: A total of 98 very preterm infants were included. Volumetric brain magnetic resonance imaging (MRI) was performed at term age, and the Movement Assessment Battery for Children-Second Edition (The Movement ABC-2) was employed at 11 y of age. The diagnosis of Developmental Coordination Disorder (DCD) was determined at 11 y of age according to the International Classification of Diseases...
September 2016: Pediatric Research
Deanne K Thompson, Jian Chen, Richard Beare, Christopher L Adamson, Rachel Ellis, Zohra M Ahmadzai, Claire E Kelly, Katherine J Lee, Andrew Zalesky, Joseph Y M Yang, Rodney W Hunt, Jeanie L Y Cheong, Terrie E Inder, Lex W Doyle, Marc L Seal, Peter J Anderson
OBJECTIVE: To use structural connectivity to (1) compare brain networks between typically and atypically developing (very preterm) children, (2) explore associations between potential perinatal developmental disturbances and brain networks, and (3) describe associations between brain networks and functional impairments in very preterm children. METHODS: 26 full-term and 107 very preterm 7-year-old children (born <30weeks' gestational age and/or <1250g) underwent T1- and diffusion-weighted imaging...
July 1, 2016: NeuroImage
Katelyn Cahill-Rowley, Jessica Rose
Children born preterm with very-low birth-weight (VLBW) have increased risk of motor impairment. Early identification of impairment guides treatment to improve long-term function. Temporal-spatial gait parameters are an easily-recorded assessment of gross motor function. The objective of this study was to characterize preterm toddlers' gait and its relationship with neurodevelopment. Velocity, cycle time, step width, step length and time asymmetry, %stance, %single-limb support, and %double-limb support were calculated for 81 VLBW preterm and 43 typically-developing (TD) toddlers...
March 2016: Gait & Posture
Louise Linsell, Reem Malouf, Joan Morris, Jennifer J Kurinczuk, Neil Marlow
AIM: There is a large literature reporting risk factor analyses for poor neurodevelopment in children born very preterm (VPT: ≤32wks) or very low birthweight (VLBW: ≤1250g), which to date has not been formally summarized. The aim of this paper was to identify prognostic factors for cerebral palsy (CP) and motor impairment in children born VPT/VLBW. METHOD: A systematic review was conducted using Medline, Embase, and Pyscinfo databases to identify studies published between 1 January 1990 and 1 June 2014 reporting multivariable prediction models for poor neurodevelopment in VPT/VLBW children (registration number CRD42014006943)...
June 2016: Developmental Medicine and Child Neurology
Jorien M Kerstjens, Ard Nijhuis, Christian V Hulzebos, Deirdre E van Imhoff, Aleid G van Wassenaer-Leemhuis, Ingrid C van Haastert, Enrico Lopriore, Titia Katgert, Renate M Swarte, Richard A van Lingen, Twan L Mulder, Céleste R Laarman, Katerina Steiner, Peter H Dijk
OBJECTIVE: To test the ability of the Ages and Stages Questionnaire, Third Edition (ASQ3) to help identify or exclude neurodevelopmental impairment (NDI) in very preterm-born children at the corrected age of two. METHODS: We studied the test results of 224 children, born at <32 postmenstrual weeks, who had scores on ASQ3 and Bayley Scales of Infant and Toddler Development, Third Edition (BSIDIII) and neurological examination at 22-26 months' corrected age. We defined NDI as a score of <70 on the cognitive--or motor composite scale of BSIDIII, or impairment on neurological examination or audiovisual screening...
2015: PloS One
H Torchin, P-Y Ancel, P-H Jarreau, F Goffinet
Every year, approximately 15 million babies are born preterm worldwide (before 37 completed weeks of gestation), putting the global preterm birth rate at 11%; they are about 60,000 in France. About 85% of these births are moderate (32-33 weeks) to late preterm babies (34-36 weeks), 10% are very preterm babies (28-31 weeks) and 5% are extremely preterm babies (< 28 weeks). Though neonatal mortality rates are dropping, they remain high and are largely determined by gestational age at birth (over 10% mortality for infants born before 28 weeks, 5-10% at 28-31 weeks and 1-2% at 32-34 weeks)...
October 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Toril Fjørtoft, Kristine Hermansen Grunewaldt, Gro C Christensen Løhaugen, Siv Mørkved, Jon Skranes, Kari Anne I Evensen
AIMS: The aims were to compare adaptive behavior in 10-11 year old VLBW children with and without cerebral palsy (CP) to term-born children, and examine its relationship with neonatal factors and infant motor repertoire in VLBW children without CP. METHODS: Twenty-eight VLBW children without CP, 10 VLBW children with CP and 31 term-born control children were examined at 10-11 years using the parent-reported Vineland Adaptive Behavior Scales-II. The Adaptive Behavior Composite Score, based on communication, daily living skills and socialization, was adjusted for sex, socioeconomic status (SES), cognitive (WISC-III) and motor function (MABC-2)...
March 2015: European Journal of Paediatric Neurology: EJPN
Verena E Pritchard, Samudragupta Bora, Nicola C Austin, Karelia J Levin, Lianne J Woodward
OBJECTIVES: Children born very preterm (VPT) are at high risk of educational delay, yet few guidelines exist for the early identification of those at greatest risk. Using a school readiness framework, this study examined relations between preschool neurodevelopmental functioning and educational outcomes to age 9 years. METHODS: The sample consisted of a regional cohort of 110 VPT (≤ 32 weeks' gestation) and 113 full-term children born during 1998-2000. At corrected age 4 years, children completed a multidisciplinary assessment of their health/motor development, socioemotional adjustment, core learning skills, language, and general cognition...
September 2014: Pediatrics
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