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https://www.readbyqxmd.com/read/28634585/high-plasma-glucagon-levels-correlate-with-waist-to-hip-ratio-suprailiac-skinfold-thickness-and-deep-subcutaneous-abdominal-and-intraperitoneal-adipose-tissue-depots-in-nonobese-asian-indian-males-with-type-2-diabetes-in-north-india
#1
Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, Harsh Mahajan, Gokulraj Prabakaran
We aimed to correlate plasma glucagon levels with anthropometric measures and abdominal adipose tissue depots. Nonobese males (n = 81; BMI < 25 kg/m(2)) with T2DM of less than one-year duration and nonobese males without diabetes (n = 30) were evaluated for the following: anthropometry (BMI, waist circumference, W-HR, and truncal skinfolds), whole-body DEXA (for body fat and fat-free mass), and MRI scan (for volumes of subcutaneous abdominal adipose tissue (SCAT) including superficial and deep, intra-abdominal visceral adipose tissue (including intraperitoneal adipose tissue (IPAT), retroperitoneal adipose tissue, liver span and fatty liver, and pancreatic volume))...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28628900/evaluation-of-the-innotyper-%C3%A2-21-genotyping-kit-in-multi-ethnic-populations
#2
Peter Gustav Ristow, Nicole Barnes, Gina Pineda Murphy, Hiromi Brown, Kevin Wesley Cloete, Maria Eugenia D'Amato
We report the findings of the evaluation of the InnoTyper(®) 21 genotyping kit for the use of human identification (HID) and paternity testing in South Africa. This novel forensic kit evaluates 20 retrotransposable elements (AC4027, MLS26, ALU79712, NBC216, NBC106, RG148, NBC13, AC2265, MLS09, AC1141, TARBP, AC2305, HS4.69, NBC51, ACA1766, NBC120, NBC10, NBC102, SB19.12 and NBC148) and the Amelogenin locus for sex determination. The evaluation of the genotyping performance showed no significant spectral pull-up for peak heights between 100 and 30,000 RFUs...
June 7, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28623152/singapore-healthy-older-people-everyday-hope-study-prevalence-of-frailty-and-associated-factors-in-older-adults
#3
Reshma A Merchant, Matthew Zhixuan Chen, Linda Wei Lin Tan, Moses YiDong Lim, Han Kwee Ho, Rob M van Dam
BACKGROUND: In the context of a rapidly ageing population, Singapore is anticipating a rise in multimorbidity, disability, and dependency, which are driven by physical frailty. Healthy Older People Everyday (HOPE) is an epidemiologic population-based study on community-dwelling older adults aged 65 years and older in Singapore. OBJECTIVE: To investigate the prevalence of frail and prefrail states and their association with polypharmacy, multimorbidity, cognitive and functional status, and perceived health status among community-dwelling older adults in Singapore...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28620678/effect-of-lifestyle-improvement-program-on-the-biomarkers-of-adiposity-inflammation-and-gut-hormones-in-overweight-obese-asian-indians-with-prediabetes
#4
Kuppan Gokulakrishnan, Harish Ranjani, Mary Beth Weber, Gautam Kumar Pandey, Ranjit Mohan Anjana, Muthuswamy Balasubramanyam, Dorairaj Prabhakaran, Nikhil Tandon, K M Venkat Narayan, Viswanathan Mohan
AIMS: While lifestyle modification is known to offer several metabolic benefits, there is paucity of comprehensive data on changes in biomarkers of adiposity, inflammation as well as gut hormones. We investigated these biomarkers in overweight/obese individuals with prediabetes randomized to either 4 months of a lifestyle improvement program or standard care and followed them up for a year. METHODS: Participants [standard care and intervention arm (n = 75 each)] were randomly selected from the Diabetes Community Lifestyle Improvement Program trial...
June 15, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28619697/depression-and-pain-in-asian-americans-and-whites-with-knee-osteoarthritis
#5
Hyochol Ahn, Michael Weaver, Debra Lyon, Eunyoung Choi, Roger B Fillingim
Few studies have examined the underlying psychosocial mechanisms of pain in Asian Americans. Using the biopsychosocial model, we sought to determine whether variations in depression contribute to racial group differences in symptomatic knee osteoarthritis pain between Asian Americans and non-Hispanic whites. The sample consisted of 100 participants, including 50 Asian Americans (28 Korean Americans, 9 Chinese Americans, 7 Japanese Americans, 5 Filipino Americans, and 1 Indian American) and 50 age- and sex-matched non-Hispanic whites with symptomatic knee osteoarthritis pain...
June 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28618394/clinicopathological-characteristics-and-survival-outcomes-of-male-breast-cancer-according-to-race-a-seer-population-based-study
#6
He-Fen Sun, Yang Zhao, Shui-Ping Gao, Liang-Dong Li, Wen-Yan Fu, Hong-Lin Jiang, Meng-Ting Chen, Li-Peng Yang, Wei Jin
To investigate the clinicopathological characteristics and survival outcomes of breast cancer in the male population, 8,607 cases of patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database, including white males (n = 7122), black males (n = 1111), and other males (American Indian/AK Native, Asian/Pacific Islander) (n = 374). Black male breast cancer patients were more likely to be in stages II-IV and have more advanced tumors. The rate of lymph node (LN) involvement at diagnosis was higher in black men than in whites and others...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615043/-like-sugar-in-milk-reconstructing-the-genetic-history-of-the-parsi-population
#7
Gyaneshwer Chaubey, Qasim Ayub, Niraj Rai, Satya Prakash, Veena Mushrif-Tripathy, Massimo Mezzavilla, Ajai Kumar Pathak, Rakesh Tamang, Sadaf Firasat, Maere Reidla, Monika Karmin, Deepa Selvi Rani, Alla G Reddy, Jüri Parik, Ene Metspalu, Siiri Rootsi, Kurush Dalal, Shagufta Khaliq, Syed Qasim Mehdi, Lalji Singh, Mait Metspalu, Toomas Kivisild, Chris Tyler-Smith, Richard Villems, Kumarasamy Thangaraj
BACKGROUND: The Parsis are one of the smallest religious communities in the world. To understand the population structure and demographic history of this group in detail, we analyzed Indian and Pakistani Parsi populations using high-resolution genetic variation data on autosomal and uniparental loci (Y-chromosomal and mitochondrial DNA). Additionally, we also assayed mitochondrial DNA polymorphisms among ancient Parsi DNA samples excavated from Sanjan, in present day Gujarat, the place of their original settlement in India...
June 14, 2017: Genome Biology
https://www.readbyqxmd.com/read/28612831/abdominal-obesity-and-type-2-diabetes-in-asian-indians-dietary-strategies-including-edible-oils-cooking-practices-and-sugar-intake
#8
REVIEW
S Gulati, A Misra
Obesity and type 2 diabetes are increasing in rural and urban regions of South Asia including India. Pattern of fat deposition in abdomen, ectopic fat deposition (liver, pancreas) and also low lean mass are contributory to early-onset insulin resistance, dysmetabolic state and diabetes in Asian Indians. These metabolic perturbations are further exacerbated by changing lifestyle, diet urbanization, and mechanization. Important dietary imbalances include increasing use of oils containing high amount of trans fatty acids and saturated fats (partially hydrogenated vegetable oil, palmolein oil) use of deep frying method and reheating of oils for cooking, high intake of saturated fats, sugar and refined carbohydrates, low intake of protein, fiber and increasing intake of processed foods...
June 14, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28610789/comparative-study-of-genotypes-of-mycobacterium-tuberculosis-from-a-northern-indian-setting-with-strains-reported-from-other-parts-of-india-and-neighboring-countries
#9
Pragya Sharma, Kiran Katoch, Shilpi Chandra, Devendra Singh Chauhan, Vishnu Dutt Sharma, David Couvin, Nalin Rastogi, Vishwa Mohan Katoch
This study was carried out to characterize Mycobacterium tuberculosis population in Ghatampur, Kanpur, North India, by spoligotyping and Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats (MIRU-VNTRs) typing. A total of 335 isolates were genotyped by spoligotyping and Central Asian (CAS) sub-lineage was the most prevalent, comprising 59.1% of all isolates. Other lineages were: East-African Indian (EAI) (19.10%), T (5.07%), Beijing (3.28%), Manu (2.98%), X (2.68%), S (0.89%), H3 (0...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28606084/effect-of-oral-cinnamon-intervention-on-metabolic-profile-and-body-composition-of-asian-indians-with-metabolic-syndrome-a-randomized-double-blind-control-trial
#10
Sonal Gupta Jain, Seema Puri, Anoop Misra, Seema Gulati, Kalaivani Mani
BACKGROUND: Nutritional modulation remains central to the management of metabolic syndrome. Intervention with cinnamon in individuals with metabolic syndrome remains sparsely researched. METHODS: We investigated the effect of oral cinnamon consumption on body composition and metabolic parameters of Asian Indians with metabolic syndrome. In this 16-week double blind randomized control trial, 116 individuals with metabolic syndrome were randomized to two dietary intervention groups, cinnamon [6 capsules (3 g) daily] or wheat flour [6 capsules (2...
June 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28598016/race-ethnicity-and-cardiovascular-events-among-patients-with-systemic-lupus-erythematosus
#11
Medha Barbhaiya, Candace H Feldman, Hongshu Guan, Jose A Gómez-Puerta, Michael A Fischer, Daniel H Solomon, Brendan Everett, Karen H Costenbader
OBJECTIVE: Systemic Lupus Erythematosus (SLE) is more prevalent with more severe outcomes among Blacks, Asians, and Hispanics than Whites. Cardiovascular disease (CVD) is the leading cause of death among SLE patients. We examined racial/ethnic variation in risk of CVD events among SLE patients. METHODS: Within Medicaid Analytic eXtract (2000-2010), we identified patients aged 18-65 with SLE (≥ 3 ICD-9 710.0 codes, ≥30 days apart) and ≥12 months of continuous enrollment...
June 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28595281/unraveling-the-population-history-of-indian-siddis
#12
Ranajit Das, Priyanka Upadhyai
The Siddis are a unique Indian tribe of African, South Asian, and European ancestry. While previous investigations have traced their ancestral origins to the Bantu populations from subSaharan Africa, the geographic localization of their ancestry has remained elusive. Here, we performed biogeographical analysis to delineate the ancestral origin of the Siddis employing an admixture based algorithm, Geographical Population Structure (GPS). We evaluated the Siddi genomes in reference to five African populations from the 1000 Genomes project, two Bantu groups from the Human Genome Diversity Panel (HGDP) and five South Indian populations...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28586255/disparities-in-assisted-reproductive-technology-utilization-by-race-and-ethnicity-united-states-2014-a-commentary
#13
Ada C Dieke, Yujia Zhang, Dmitry M Kissin, Wanda D Barfield, Sheree L Boulet
Disparities in infertility and access to infertility treatments, such as assisted reproductive technology (ART), by race/ethnicity, have been reported. However, identifying disparities in ART usage may have been hampered by missing race/ethnicity information in ART surveillance. We review infertility prevalence and treatment disparities, use recent data to examine ART use in the United States by race/ethnicity and residency in states with mandated insurance coverage for in vitro fertilization (IVF), and discuss approaches for reducing disparities...
June 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28570299/hla-a-31-01-and-hla-b-15-02-association-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-to-carbamazepine-in-a-multiethnic-malaysian-population
#14
Amy Hui-Ping Khor, Kheng-Seang Lim, Chong-Tin Tan, Zhenli Kwan, Wooi-Chiang Tan, David Bin-Chia Wu, Ching-Ching Ng
The majority of the carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis CBZ-SJS/TEN are associated with HLA-B*15:02 in Asian populations where this allele is common. In contrast, the association with HLA-A*31:01 is only reported in Japanese and Europeans. This study aimed to further investigate the association with HLA-A*31:01 besides HLA-B*15:02 in a multiethnic Malaysian population. Twenty-eight CBZ-SJS/TEN cases and 227 CBZ-tolerant controls were recruited. Association was tested by comparing carrier frequencies of the alleles between cases and controls...
July 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28562272/racial-and-ethnic-trends-in-sudden-unexpected-infant-deaths-united-states-1995-2013
#15
Sharyn E Parks, Alexa B Erck Lambert, Carrie K Shapiro-Mendoza
BACKGROUND AND OBJECTIVES: Immediately after the 1994 Back-to-Sleep campaign, sudden unexpected infant death (SUID) rates decreased dramatically, but they have remained relatively stable (93.4 per 100 000 live births) since 2000. In this study, we examined trends in SUID rates and disparities by race/ethnicity since the Back-to-Sleep campaign. METHODS: We used 1995-2013 US period-linked birth-infant death data to evaluate SUID rates per 100 000 live births by non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic, American Indian/Alaska Native, and Asian/Pacific Islander racial/ethnic groupings...
May 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28561680/thinking-differently-in-global-health-in-oncology-using-a-diagonal-approach-harnessing-similarities-improving-education-and-empowering-an-alternative-oncology-workforce
#16
Natalia M Rodriguez, Jeannine M Brant, Dinesh Pendharkar, Hector Arreola-Ornelas, Afsan Bhadelia, Gilberto de Lima Lopes, Felicia M Knaul
Cancer is a leading global cause of death, and diverse and minority populations suffer worse outcomes compared with white people from Western societies. Within the United States, African Americans and other blacks, Hispanics, Asians, and American Indians have lower cancer survival rates than whites. In the rest of the world, those from low- and middle-income countries have the greatest disparities, but even those from non-Western high-income countries such as Oman and the United Arab Emirates are diagnosed with cancer at later stages and suffer increased mortality...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28554997/direct-vs-expressed-breast-milk-feeding-relation-to-duration-of-breastfeeding
#17
Wei Wei Pang, Jonathan Y Bernard, Geetha Thavamani, Yiong Huak Chan, Doris Fok, Shu-E Soh, Mei Chien Chua, Sok Bee Lim, Lynette P Shek, Fabian Yap, Kok Hian Tan, Peter D Gluckman, Keith M Godfrey, Rob M van Dam, Michael S Kramer, Yap-Seng Chong
BACKGROUND: Studies examining direct vs. expressed breast milk feeding are scarce. We explored the predictors of mode of breastfeeding and its association with breastfeeding duration in a multi-ethnic Asian population. METHODS: We included 541 breastfeeding mother-infant pairs from the Growing Up in Singapore Toward healthy Outcomes cohort. Mode of breastfeeding (feeding directly at the breast, expressed breast milk (EBM) feeding only, or mixed feeding (a combination of the former 2 modes)) was ascertained at three months postpartum...
May 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28547738/implementing-health-promotion-activities-using-community-engaged-approaches-in-asian-american-faith-based-organizations-in-new-york-city-and-new-jersey
#18
S C Kwon, S Patel, C Choy, J Zanowiak, C Rideout, S Yi, L Wyatt, M D Taher, M J Garcia-Dia, S S Kim, T K Denholm, R Kavathe, N S Islam
Faith-based organizations (FBOs) (e.g., churches, mosques, and gurdwaras) can play a vital role in health promotion. The Racial and Ethnic Approaches to Community Health for Asian Americans (REACH FAR) Project is implementing a multi-level and evidence-based health promotion and hypertension (HTN) control program in faith-based organizations serving Asian American (AA) communities (Bangladeshi, Filipino, Korean, Asian Indian) across multiple denominations (Christian, Muslim, and Sikh) in New York/New Jersey (NY/NJ)...
May 25, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28545458/determinants-of-eating-at-local-and-western-fast-food-venues-in-an-urban-asian-population-a-mixed-methods-approach
#19
Nasheen Naidoo, Rob M van Dam, Sheryl Ng, Chuen Seng Tan, Shiqi Chen, Jia Yi Lim, Mei Fen Chan, Ling Chew, Salome A Rebello
BACKGROUND: Like several Southeast Asian countries, Singapore has a complex eating-out environment and a rising eating-out prevalence. However the determinants and drivers of eating-out in urban Asian environments are poorly understood. METHODS: We examined the socio-demographic characteristics of persons who frequently ate away from home in local eateries called hawker centres and Western fast-food restaurants, using data from 1647 Singaporean adults participating in the National Nutrition Survey (NNS) 2010...
May 25, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28544478/the-protective-role-of-physical-activity-on-type-2-diabetes-an-analysis-of-effect-modification-by-race-ethnicity
#20
William R Boyer, James R Churilla, Samantha F Ehrlich, Scott E Crouter, Lyndsey M Hornbuckle, Eugene C Fitzhugh
BACKGROUND: It is well known physical activity (PA) plays a role in the prevention of type 2 diabetes (T2D). However, the extent to which PA may impact T2D risk among different race-ethnic groups is unknown. Therefore, the purpose of this study was to systematically examine the effect modification of race-ethnicity on PA and T2D. METHODS: PubMed and Embase databases were systematically searched through June 2016. Study assessment for inclusion was conducted in three phases: 1) title review (N = 13,022), 2) abstract review (N = 2,200), and 3) full text review (N = 265)...
May 24, 2017: Journal of Diabetes
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