keyword
https://read.qxmd.com/read/38359389/biologically-self-assembled-tumor-cell-derived-cancer-nanovaccines-as-an-all-in-one-platform-for-cancer-immunotherapy
#21
JOURNAL ARTICLE
Kaifan Liang, Yinzhe Sun, Laozhi Xie, Yipu Liu, Yang You, Jianpei Xu, Fenfen Ma, Yukun Huang, Qingxiang Song, Wenze Xiao, Jianming Huang, Xiaoling Gao, Jun Chen
Tumor cell-derived cancer nanovaccines introduce tumor cell-derived components as functional units that endow the nanovaccine systems with some advantages, especially providing all potential tumor antigens. However, cumbersome assembly steps, potential risks of exogenous adjuvants, as well as insufficient lymph node (LN) targeting and dendritic cell (DC) internalization limit the efficacy and clinical translation of existing tumor cell-derived cancer nanovaccines. Herein, we introduced an endoplasmic reticulum (ER) stress inducer α-mangostin (αM) into tumor cells through poly(d, l-lactide- co -glycolide) nanoparticles and harvested biologically self-assembled tumor cell-derived cancer nanovaccines (αM-Exos) based on the biological process of tumor cell exocytosing nanoparticles through tumor-derived exosomes (TEXs)...
February 15, 2024: ACS Nano
https://read.qxmd.com/read/38353543/decoration-of-burkholderia-hcp1-protein-to-virus-like-particles-as-a-vaccine-delivery-platform
#22
JOURNAL ARTICLE
Nittaya Khakhum, Noe Baruch-Torres, Jacob L Stockton, Itziar Chapartegui-González, Alexander J Badten, Awadalkareem Adam, Tian Wang, Alejandro Huerta-Saquero, Y Whitney Yin, Alfredo G Torres
Virus-like particles (VLPs) are protein-based nanoparticles frequently used as carriers in conjugate vaccine platforms. VLPs have been used to display foreign antigens for vaccination and to deliver immunotherapy against diseases. Hemolysin-coregulated proteins 1 (Hcp1) is a protein component of the Burkholderia type 6 secretion system, which participates in intracellular invasion and dissemination. This protein has been reported as a protective antigen and is used in multiple vaccine candidates with various platforms against melioidosis, a severe infectious disease caused by the intracellular pathogen Burkholderia pseudomallei ...
February 14, 2024: Infection and Immunity
https://read.qxmd.com/read/38352881/self-assembling-ferritin-nanoplatform-for-the-development-of-infectious-hematopoietic-necrosis-virus-vaccine
#23
JOURNAL ARTICLE
Sohrab Ahmadivand, Zeljka Krpetic, Merce Márquez Martínez, Marlid Garcia-Ordoñez, Nerea Roher, Dušan Palić
Self-assembling protein nanoparticles are used as a novel vaccine design platform to improve the stability and immunogenicity of safe subunit vaccines, while providing broader protection against viral infections. Infectious Hematopoietic Necrosis virus (IHNV) is the causative agent of the WOAH-listed IHN diseases for which there are currently no therapeutic treatments and no globally available commercial vaccine. In this study, by genetically fusing the virus glycoprotein to the H. pylori ferritin as a scaffold, we constructed a self-assembling IHNV nanovaccine (FerritVac)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38349234/antigen-self-presented-personalized-nanovaccines-boost-the-immunotherapy-of-highly-invasive-and-metastatic-tumors
#24
JOURNAL ARTICLE
Tingting Wang, Mengxiao Han, Yaobao Han, Zhilin Jiang, Qing Zheng, Hao Zhang, Zhen Li
Dendritic cell (DC)-based vaccines have shown promise in adoptive cell therapy for enhancing the antigen-specific response of antitumor immunity. However, their clinical efficacy is limited by the less-presented tumor-associated antigens (TAAs) through MHC I and low lymph node homing efficiency. Herein, to address these issues, we rationally design and fabricate DC-based nanovaccines by coating Cu2- x Se nanoparticles (CS NPs) with the membrane of matured DCs (named as DCNV(CSD) nanovaccines). We reveal the important roles of CS NPs in the DCNV(CSD) nanovaccines from three aspects: (1) inducing the immunogenic cell death of tumor cells to expose abundant TAAs; (2) promoting the escape of TAAs from the lysosomes of DCs during the antigen presenting process through MHC I; (3) sustainably releasing traces of copper ions to promote the proliferation of T cells...
February 13, 2024: ACS Nano
https://read.qxmd.com/read/38346262/development-and-immunological-evaluation-of-a-multiantigen-thermostable-nanovaccine-adjuvanted-with-t-cell-activating-scaffold-for-african-swine-fever
#25
JOURNAL ARTICLE
Lidan Sun, Jinsong Zhang, Lijun Shi, Yuanli Peng, Xiangning Feng, Fang Huang, Feixia Yang, Jinyu Li, Shuo Wang, Jingqi Niu, Jinling Liu, Yingjun Li, Shanhu Li, Zeliang Chen
African swine fever is an acute and highly contagious infectious disease with a mortality rate of up to 100%. The lack of commercial vaccines and drugs is a serious economic threat to the global pig industry. Cell-mediated immunity plays an essential role in protection against viral infection. We previously reported the rational design of a T-cell-activating thermostable scaffold (RPT ) for antigen delivery and improved cellular immunity. We conjugated antigens P30, P54, P72, CD2 V, and CP312R to RPT , using a SpyCatcher/SpyTag covalent attachment strategy to construct nanovaccines (multiantigens-RPT )...
February 12, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38341011/engineered-photonic-near-infrared-light-activated-photothermal-theranostic-nanovaccine-induced-targeted-remodeling-of-tumor-microenvironment
#26
JOURNAL ARTICLE
Karunanidhi Gowsalya, Babu Rithisa, Yuvaraj Haldorai, Krishnamurthy Shanthi, Raju Vivek
Tumor recurrence, which happens as a result of persisting tumor cells and minor lesions after treatments like surgery and chemotherapy, is a major problem in oncology. Herein, a strategy to combat this issue by utilize a theranostic nanovaccine composed of photonic HCuS. This nanovaccine aims to eradicate cancer cells and their traces while also preventing tumor recurrence via optimizing the photothermal immune impact. Successful membrane targeting allows for the introduction of new therapeutic agents into the tumor cells...
February 8, 2024: Nanomedicine: Nanotechnology, Biology, and Medicine
https://read.qxmd.com/read/38340040/a-divalent-chikungunya-and-zika-nanovaccine-with-thermostable-self-assembly-multivalent-scaffold-ls-sumo
#27
JOURNAL ARTICLE
Qianlin Li, Jinsong Zhang, Qiang Deng, Conghui Liao, Jun Qian, Zeliang Chen, Jiahai Lu
The convergence strategies of antigenic subunits and synthetic nanoparticle scaffold platform improve the vaccine production efficiency and enhance vaccine-induced immunogenicity. The selection of the appropriate nanoparticle scaffold is critical for the immunological control of the target antigens. Lumazine synthase (LS) is an attractive candidate for a vaccine display system due to its thermo-stability, modification tolerance, and morphological plasticity. Here, the first development of a multivalent thermostable scaffold, LS-SUMO, and a divalent nanovaccine covalently conjugated with CHIKV E2 and ZIKV EDIII antigens, was reported...
February 10, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38335676/live-attenuated-mycobacterium-bovis-strains-combined-with-the-encapsulated-h65-antigen-as-a-vaccine-strategy-against-bovine-tuberculosis-in-a-mouse-model
#28
JOURNAL ARTICLE
Renée Onnainty, María Rocío Marini, María José Gravisaco, Elizabeth Andrea García, Clauss Aagaard, Ana Canal, Gladys Granero, Fabiana Bigi, Federico Carlos Blanco
Mycobacterium bovis is an etiological agent of bovine tuberculosis (bTB) that also infects other mammals, including humans. The lack of an effective vaccine for the control of bTB highlights the need for developing new vaccines. In this study, we developed and evaluated an M. bovis strain deleted in the virulence genes phoP, esxA and esxB as a vaccine candidate against bTB in BALBc mice. The evaluated strains were the new live vaccine and BCG, alone or in combination with ncH65vD. The immunogen ncH65vD is a fusion protein H65, encapsulated together with vitamin D3, within the oily body of a nanocapsule composed of an antigen-loading polymeric shell...
January 26, 2024: Veterinary Microbiology
https://read.qxmd.com/read/38331707/hit-and-run-vaccine-system-that-overcomes-limited-neoantigen-epitopes-for-efficient-broad-antitumor-response
#29
JOURNAL ARTICLE
Hongyu Chen, Zichao Huang, Jiaxuan Li, Si Dong, Yudi Xu, Sheng Ma, Jiayu Zhao, Liping Liu, Tianmeng Sun, Wantong Song, Xuesi Chen
Neoantigen cancer vaccines have been envisioned as one of the most promising means for cancer therapies. However, identifying neoantigens for tumor types with low tumor mutation burdens continues to limit the effectiveness of neoantigen vaccines. Herein, we proposed a "hit-and-run" vaccine strategy which primes T cells to attack tumor cells decorated with exogenous "neo-antigens". This vaccine strategy utilizes a peptide nanovaccine to elicit antigen-specific T cell responses after tumor-specific decoration with a nanocarrier containing the same peptide antigens...
February 1, 2024: Science Bulletin
https://read.qxmd.com/read/38329387/preparation-of-glycopeptide-modified-ph-sensitive-liposomes-for-promoting-antigen-cross-presentation-and-induction-of-antigen-specific-cellular-immunity
#30
JOURNAL ARTICLE
Eiji Yuba, Rajesh Kumar Gupta
Cross-presentation, exogenous antigen presentation onto major histocompatibility complex class I molecules on antigen presenting cells, is crucially important for inducing antigen-specific cellular immune responses for cancer immunotherapy and for the treatment of infectious diseases. One strategy to induce cross-presentation is cytosolic delivery of an exogenous antigen using fusogenic or endosomolytic molecule-introduced nanocarriers. Earlier, we reported liposomes modified with pH-responsive polymers to achieve cytosolic delivery of an antigen...
February 8, 2024: Biomaterials Science
https://read.qxmd.com/read/38320299/genetically-engineered-cytomembrane-nanovaccines-for-cancer-immunotherapy
#31
JOURNAL ARTICLE
Yuanwei Pan, Xianjia Wu, Lujie Liu, Chenchen Zhao, Jing Zhang, Shengren Yang, Pan Pan, Qinqin Huang, Xing-Zhong Zhao, Rui Tian, Lang Rao
Cancer nanovaccines have attracted widespread attention by inducing potent cytotoxic T cell responses to improve immune checkpoint blockade (ICB) therapy, while the lack of co-stimulatory molecules limits their clinical applications. Here, we report a genetically engineered cancer cytomembrane nanovaccine that simultaneously overexpresses co-stimulatory molecule CD40L and immune checkpoint inhibitor PD1 to elicit robust antitumor immunity for cancer immunotherapy. The CD40L and tumor antigens inherited from cancer cytomembranes effectively stimulated dendritic cell (DC)-mediated immune activation of cytotoxic T cells, while the PD1 on cancer cytomembranes significantly blocked PD1/PD-L1 signaling pathway, synergistically stimulating antitumor immune responses...
February 6, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38312800/human-serum-albumin-as-the-carrier-to-fabricate-sting-activating-peptide-nanovaccine-for-antitumor-immunotherapy
#32
JOURNAL ARTICLE
Aixian Zheng, Zhaoyu Ning, Xiaorong Wang, Zhenli Li, Yupeng Sun, Ming Wu, Da Zhang, Xiaolong Liu, Jianwu Chen, Yongyi Zeng
Tumor vaccines are emerging as one of the most promising therapeutic strategies for cancer treatment. With the advantages of low toxicity, convenient production and stable quality control, peptide vaccines have been widely used in preclinical and clinical trials involving various malignancies. However, when used alone, they still suffer from significant challenges including poor stability and immunogenicity as well as the low delivery efficiency, leading to limited therapeutic success. Herein, the STING-activating peptide nanovaccine based on human serum albumin (HSA) and biodegradable MnO2 was constructed, which can improve the stability and immunogenicity of antigenic peptides as well as facilitate their uptake by dendritic cells (DCs)...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38310250/oral-administration-of-dna-alginate-nanovaccine-induced-immune-protection-against-helicobacter-pylori-in-balb-c-mice
#33
JOURNAL ARTICLE
Arezo Kaveh-Samani, Samaneh Dalali, Fatemeh Kaviani, Tohid Piri-Gharaghie, Abbas Doosti
BACKGROUND: Helicobacter pylori (H. Pylori), is an established causative factor for the development of gastric cancer and the induction of persistent stomach infections that may lead to peptic ulcers. In recent decades, several endeavours have been undertaken to develop a vaccine for H. pylori, although none have advanced to the clinical phase. The development of a successful H. pylori vaccine is hindered by particular challenges, such as the absence of secure mucosal vaccines to enhance local immune responses, the absence of identified antigens that are effective in vaccinations, and the absence of recognized indicators of protection...
February 3, 2024: BMC Immunology
https://read.qxmd.com/read/38308196/spatiotemporal-controllable-sono-nanovaccines-driven-by-free-field-based-whole-body-ultrasound-for-personalized-cancer-therapy
#34
JOURNAL ARTICLE
Yang Wang, Guangzhe Li, Jianlong Su, Yiming Liu, Xiaomai Zhang, Guanyi Zhang, Zhihao Wu, Jinrong Li, Yuxuan Zhang, Xu Wang, Zejia Yang, Ruimin Wang, Chengdong Wang, Liu Wang, Fangfang Sun, Weijie Zhao, Xuejian Wang, Xiaojun Peng, Kun Shao
Therapeutic cancer vaccines fail to produce satisfactory outcomes against solid tumors since vaccine-induced anti-tumor immunity is significantly hampered by immunosuppression. Generating an in situ cancer vaccine targeting immunological cold tumor microenvironment (TME) appears attractive. Here, a type of free-field based whole-body ultrasound (US)-driven nanovaccines are constructed, named G5-CHC-R, by conjugating the sonosensitizer, Chenghai chlorin (CHC) and the immunomodulator, resiquimod (R848) on top of a super small-sized dendrimeric nanoscaffold...
February 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38308123/a-bioengineered-nanovesicle-vaccine-boosts-t-b-cell-interaction-for-immunotherapy-of-echinococcus-multilocularis
#35
JOURNAL ARTICLE
Xiaoyu An, Wei Xiang, Xue Liu, Shuo Li, Zhijian Xu, Pan He, Ri-Li Ge, Feng Tang, Zhe Cheng, Chao Liu, Gang Liu
Alveolar echinococcosis (AE) is a zoonotic parasitic disease, resulting from being infected with the metacestode larvae of the tapeworm Echinococcus multilocularis. Novel prophylactic and therapeutic interventions are urgently needed since the current chemotherapy displays limited efficiency in AE treatment. Bioengineered nano cellular membrane vesicles are widely used for displaying the native conformational epitopes because of their unique structure and biocompatibility. In this study, four T-cells and four B-cells dominant epitope peptides of E...
February 2, 2024: Angewandte Chemie
https://read.qxmd.com/read/38301413/peptide-nanovaccine-in-melanoma-immunotherapy
#36
REVIEW
Mahvash Dehghankhold, Samira Sadat Abolmaali, Navid Nezafat, Ali Mohammad Tamaddon
Melanoma is an especially fatal neoplasm resistant to traditional treatment. The advancement of novel therapeutical approaches has gained attention in recent years by shedding light on the molecular mechanisms of melanoma tumorigenesis and their powerful interplay with the immune system. The presence of many mutations in melanoma cells results in the production of a varied array of antigens. These antigens can be recognized by the immune system, thereby enabling it to distinguish between tumors and healthy cells...
January 31, 2024: International Immunopharmacology
https://read.qxmd.com/read/38288709/a-versatile-nanovaccine-enhancement-strategy-based-on-suction-inspired-physical-therapy
#37
JOURNAL ARTICLE
Jiayan Wu, Yuanji Feng, Xiaoya Guo, Meng Meng, Huixin Li, Huapan Fang, Zhen Li, Lin Lin, Zhaopei Guo, Jie Chen, Huayu Tian, Xuesi Chen
Vaccine technology is effective in preventing and treating diseases, including cancers and viruses. The efficiency of vaccines can be improved by increasing the dosage and frequency of injections, but it would bring an extra burden to people. Therefore, it is necessary to develop vaccine-boosting techniques with negligible side effects. Herein, we reported a cupping-inspired noninvasive suction therapy that could enhance the efficacy of cancer/SARS-CoV-2 nanovaccines. Negative pressure caused mechanical immunogenic cell death and released endogenous adjuvants...
January 30, 2024: ACS Nano
https://read.qxmd.com/read/38271787/hypoxia-activated-cascade-nanovaccine-for-synergistic-chemoembolization-immune-therapy-of-hepatocellular-carcinoma
#38
JOURNAL ARTICLE
Qin Shi, Wen Zhang, Yongjie Zhou, Songjiang Huang, Jiaze Yu, Minjie Yang, Zihan Zhang, Jingqin Ma, Jianjun Luo, Shengxiang Rao, Daru Lu, Shaojun Peng, Yongbin Cao, Lingxiao Liu, Zhiping Yan
In this work, a promising treatment strategy for triggering robust antitumor immune responses in transarterial chemoembolization of hepatocellular carcinoma (HCC) is presented. The zeolitic imidazolate framework nanoparticles loaded with hypoxia-activated prodrug tirapazamine and immune adjuvant resiquimod facilitated in situ generation of nanovaccine via a facile approach. The nanovaccine can strengthen the ability of killing the liver cancer cells under hypoxic environment, while was capable of improving immunogenic tumor microenvironment and triggering strong antitumor immune responses by increasing the primary and distant intratumoral infiltration of immune cells such as cytotoxic T cells...
January 21, 2024: Biomaterials
https://read.qxmd.com/read/38270089/rna-origami-functions-as-a-self-adjuvanted-nanovaccine-platform-for-cancer-immunotherapy
#39
JOURNAL ARTICLE
Theresa Yip, Xiaodong Qi, Hao Yan, Yung Chang
Peptide-based vaccines have been widely investigated in cancer immunotherapy. Despite their high specificity, safety, and low production cost, these vaccines have shown limited success in clinical studies, owing to their poor immunogenicity. Extensive efforts have been devoted to increasing the immunogenicity of peptide vaccines by mixing peptides with adjuvants and/or promoting their delivery to tumor-draining lymph nodes (TdLNs) for better antigen presentation by and maturation of dendritic cells. Among these efforts, the exploration of various nanoparticles has been at the forefront of the rational design and construction of peptide-based vaccines...
January 25, 2024: ACS Nano
https://read.qxmd.com/read/38267696/optimized-refolding-buffers-oriented-humoral-immune-responses-versus-pfgcs1-self-assembled-peptide-nanoparticle
#40
JOURNAL ARTICLE
Leila Nourani, Anita Lotfi, Hediye Vand-Rajabpour, Zeinab Pourhashem, Fahimeh Nemati, Akram Abouie Mehrizi
Developing a novel class of vaccine is pivotal for eliminating and eradicating malaria. Preceding investigations demonstrated partial blocking activity in malaria transmission against recombinant vaccine PfHAP2-GCS1 and conserved region of the cd loop. The effectiveness of immune response varies with the size and shape of the self-assembly of peptide nanoparticles (SAPNs) displaying antigen, affected by different components in refolding buffers. Plasmodium falciparum Generative Cell Specific 1 (PfGCS1), a promising malaria transmission-blocking vaccine (TBV) candidate, was expressed, purified, and followed by a four-step refolding process to form nanoparticles (PfGCS1-SAPNs)...
January 24, 2024: Molecular Biotechnology
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