Yang Wang, Guangzhe Li, Jianlong Su, Yiming Liu, Xiaomai Zhang, Guanyi Zhang, Zhihao Wu, Jinrong Li, Yuxuan Zhang, Xu Wang, Zejia Yang, Ruimin Wang, Chengdong Wang, Liu Wang, Fangfang Sun, Weijie Zhao, Xuejian Wang, Xiaojun Peng, Kun Shao
Therapeutic cancer vaccines fail to produce satisfactory outcomes against solid tumors since vaccine-induced anti-tumor immunity is significantly hampered by immunosuppression. Generating an in situ cancer vaccine targeting immunological cold tumor microenvironment (TME) appears attractive. Here, a type of free-field based whole-body ultrasound (US)-driven nanovaccines are constructed, named G5-CHC-R, by conjugating the sonosensitizer, Chenghai chlorin (CHC) and the immunomodulator, resiquimod (R848) on top of a super small-sized dendrimeric nanoscaffold...
February 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)