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https://www.readbyqxmd.com/read/29161808/renal-outcome-of-congenital-anomalies-of-the-kidney-and-urinary-tract-system-a-singe-center-retrospective-study
#1
Rahime Renda
BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) have been defined in 20 to 50% of all fetal anomalies. The aim of this study was to determine the demographic and clinical characteristics of such patients, as well as to describe the outcome and risk factors that affect the prognosis. METHODS: The analysis investigated retrospective data from 303 patients diagnosed with CAKUT between January 2015 and April 2017. Demographic data, clinical history, diagnosis, investigations, disease outcomes, and treatment procedures were evaluated...
November 21, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29161801/impact-of-sarcopenia-on-long-term-mortality-and-cardiovascular-events-in-patients-undergoing-hemodialysis
#2
Jwa-Kyung Kim, Sung Gyun Kim, Ji-Eun Oh, Young-Ki Lee, Jung-Woo Noh, Hyung Jik Kim, Young Rim Song
Background/Aims: A high body mass index (BMI) is known to correlate with better survival in patients on hemodialysis (HD). However, the impacts of body composition and sarcopenia on survival have not been well studied in this population. Methods: One hundred and forty-two prevalent HD patients were recruited and followed prospectively for up to 4.5 years. Low muscle mass (measured using a portable, whole-body, bioimpedance spectroscopic device) was defined as a lean tissue index (LTI) two standard deviations (SD) or more below the normal gender-specific mean for young people...
November 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29161792/-trend-in-the-eradication-rates-of-helicobacter-pylori-infection-over-the-last-10-years-in-west-gyeonggi-do-korea-a-single-center-experience
#3
Jong Seol Park, Ji Eun Park, Byoung Soo Oh, Byung Wook Yoon, Hyun Ki Kim, Jae Won Lee, Nam Ho Kim, Won Seok Cho, Young Sik Woo, Jaehoon Jahng, Yong Sung Kim
Background/Aims: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea. Methods: The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29161783/cancer-treatment-and-management-for-elderly-patients-80-years-of-age-or-older-with-malignant-solid-tumors
#4
Mao Matsubayashi, Fumihiro Oshita, Natsuki Kawata, Takafumi Yanagibashi, Satoshi Tanaka, Yoshiteru Hao, Yuichi Kurakami, Keisuke Iwabuchi, Yohsuke Kunishi, Mitsuyasu Ohta, Yuki Nakamura, Kohichiro Yoshie
We retrospectively analyzed the backgrounds, treatment and nursing care for 96 patients aged 80 years or more with malignant tumors. Twenty of them were hospitalized on an emergency basis. Sixty patients were male and 36 were female, with a median age of 83 years (range: 80-94 years). Twenty-seven had a PS of 3 or 4, and 41 were rated as not independent based on analysis of autonomy at hospitalization. Forty-seven patients had clinical stage III or IV malignancies. The proportions of patients with disease complications were 33...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161779/micronuclei-assay-in-exfoliated-buccal-cells-of-radiation-treated-oral-cancer-patients
#5
Gayathri Ramesh, Smriti Chaubey, Amrita Raj, Ravi Kumar Seth, Anuradha Katiyar, Amit Kumar
BACKGROUND: Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. Evaluation of radiation-induced cellular changes to predict radiosensitivity has invested many investigators since such changes were first found in biopsy material. AIM: The aim of the present study was to assess the relationship of with histopathological grade and number of radiation therapy sittings with the frequency of micronuclei and nuclear anomalies among oral cancer patients...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161770/twin-models-of-environmental-and-genetic-influences-on-pubertal-development-salivary-testosterone-and-estradiol-in-adolescence
#6
Andrew D Grotzinger, Frank D Mann, Megan W Patterson, Kathrin Herzhoff, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
OBJECTIVE: Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol and pubertal status, into genetic and environmental components. DESIGN: A sample of male and female adolescent twins from the greater Austin and Houston areas provided salivary samples, with a subset of participants providing longitudinal data at two waves. PARTICIPANTS: The sample included 902 adolescent twins, 49% female, ages 13-20 years (M = 15...
November 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29161769/influence-of-biceps-brachii-tendon-mechanical-properties-on-elbow-flexor-force-steadiness-in-young-and-old-males
#7
Rowan R Smart, Stéphane Baudry, Andrey Fedorov, Samantha L Kuzyk, Jennifer M Jakobi
Elbow flexor force steadiness (FS) depends on strength and decreases with age. Achilles tendon mechanics effect standing balance and isometric plantarflexion FS. This study investigated the influence of distal biceps brachii (BB) tendon mechanics and elbow flexor strength on age-related decline in FS. Nine young (23±2 years) and 9 old (77±5 years) males performed submaximal isometric elbow flexion tasks at low (2.5, 5, 10% maximal voluntary contraction (MVC)) and high (20, 40, 60, 80%MVC) forces in a neutral forearm position...
November 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29161710/distribution-of-hepatitis-c-virus-genotypes-and-subtypes-in-the-metropolitan-area-of-naples-italy-in-the-era-of-interferon-free-regimens
#8
Elena Grimaldi, Maria Elena Della Pepa, Francesca Martora, Pasqualino Magliocca, Maria Rosaria Iovene, Nicola Coppola, Giovanna Donnarumma, Massimiliano Galdiero
AIMS: The objective of this work was to study the distribution of hepatitis C virus (HCV) genotypes and subtypes from 2010 to 2015 in 1,221 anti-HCV/HCV-RNA-positive specimens from patients living in the metropolitan area of Naples, since HCV genotypes and subtypes remain cornerstones in the management of chronic HCV infection even in the directly acting antivirals era. METHODS: The study was carried out on 1,221 anti-HCV/HCV-RNA-positive plasma samples collected between April 2010 and December 2015...
November 22, 2017: Intervirology
https://www.readbyqxmd.com/read/29161686/impact-of-an-in-hospital-patient-education-program-on-choice-of-renal-replacement-modality-in-unplanned-dialysis-initiation
#9
Moritz Schanz, Markus Ketteler, Markus Heck, Juergen Dippon, Mark Dominik Alscher, Martin Kimmel
BACKGROUND/AIMS: Up to 50% patients requiring dialysis receive an urgent, unplanned start (UPS) to renal replacement therapy (RRT). Most of these are initiated with an intravenous catheter and commenced and maintained on hemodialysis (HD). Although peritoneal dialysis (PD) could be an equipotent initial modality for RRT, it is used less frequently as long-term RRT in UPS patients. This multicenter-study aimed to evaluate the impact of a structured, in-hospital education program and factors influencing PD rates, especially in UPS patients...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29161668/patterns-of-c-reactive-protein-ratio-response-to-antibiotics-in-pediatric-sepsis-a-prospective-cohort-study
#10
Vanessa Soares Lanziotti, Pedro Póvoa, Arnaldo Prata-Barbosa, Lucas Berbet Pulcheri, Ligia S C F Rabello, José Roberto Lapa E Silva, Marcio Soares, Jorge I F Salluh
PURPOSE: Evaluate sequential C-reactive protein (CRP) measurements and patterns of CRP-ratio response to antibiotic therapy during first 7days in Pediatric Intensive Care Unit (PICU) of septic children. METHODS: Prospective, cohort study of children (1month-12years) admitted at 3 PICUs, with diagnosis of sepsis with <72h course. CRP-ratio was calculated in relation to D0_CRP value. Children were classified according to an individual pattern of CRP-ratio response: fast - CRP_D4 of therapy was <0...
November 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29161577/histological-characteristics-of-the-gonads-of-pig-fetuses-and-their-relationship-with-fetal-anatomical-measurements
#11
Thais Preisser Pontelo, José Rafael Miranda, Matheus Augusto Rodrigues Felix, Barbara Azevedo Pereira, William Eduardo da Silva, Gleide Fernandes Avelar, Flávia Cristina Martins Queiroz Mariano, Gregório Corrêa Guimarães, Márcio Gilberto Zangeronimo
The objective was to evaluate the histomorphometric characteristics of the testis and ovaries of pig fetuses at different gestational ages, as well as their correlation with some fetus measurements. Forty-four fetuses were separated for gender (male and female) and gestational age (50, 80 and 106days of gestation). After slaughter, fetuses had their body length, head and thoracic perimeters measured and their gonads submitted to histomorphometric analyses. The gonadal characteristics at different gestational ages were statistically compared, correlations with the fetal measurements were performed and equations to predict the gonadal characteristics from the fetal measurements were obtained...
November 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29161441/contributions-of-function-altering-variants-in-genes-implicated-in-pubertal-timing-and-body-mass-for-self-limited-delayed-puberty
#12
Sasha R Howard, Leonardo Guasti, Ariel Poliandri, Alessia David, Claudia P Cabrera, Michael R Barnes, Karoliina Wehkalampi, Stephen O'Rahilly, Catherine E Aiken, Anthony P Coll, Marcella Ma, Debra Rimmington, Giles S H Yeo, Leo Dunkel
Context: Self-limited delayed puberty (DP) is often associated with delay in physical maturation, but whilst highly heritable the causal genetic factors remain elusive. Genome-wide association studies of the timing of puberty have identified multiple loci for age of menarche (AAM) in females and voice break in males, particularly in pathways controlling energy balance. Objective/Main outcome measures: We aimed to assess the contribution of rare variants in such genes to the phenotype of familial DP...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29161190/using-video-stimuli-to-examine-judgments-of-non-offending-and-offending-pedophiles-a-brief-communication
#13
Katie A Boardman, Ross M Bartels
In this experimental study, 89 participants were allocated to an offending pedophile; non-offending pedophile; or control video condition. They then watched two short help-seeking video-clips of an older male and a younger male (counterbalanced). Judgments about each male were assessed, as were general attitudes towards pedophiles and sexual offenders. Offending pedophiles were judged as more deserving of punishment than the non-offending pedophiles and controls. Age of the male was found to have an effect on judgments of dangerousness...
November 21, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29161167/depression-and-marijuana-use-among-a-sample-of-urban-females-is-stage-of-development-important
#14
Leah Floyd Campbell
BACKGROUND: Increasing rates of marijuana use and high rates of depression among females are major public health concerns and ambiguous study results suggest a complex association between the two. Inconsistent findings may be due to differences in sample characteristics (e.g., females vs. males) and result from differences in the relationship over time (i.e., across developmental stages). OBJECTIVES: Presently, the extent to which the relationship between depression and marijuana use differed for females in emerging adulthood, compared to young adult females, was examined...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29161165/alcohol-misuse-in-reserve-soldiers-and-their-partners-cross-spouse-effects-of-deployment-and-combat-exposure
#15
Bonnie M Vest, Sarah Cercone Heavey, D Lynn Homish, Gregory G Homish
BACKGROUND: Military deployment and combat are associated with worse outcomes, including alcohol misuse. Less is known about how these experiences affect soldiers' spouses. OBJECTIVE: The study objective was to explore relationships between deployment, combat exposure, and alcohol misuse; especially cross-spouse effects (effect of one partner's experiences/behavior on the other partner), which has been under-examined in military samples. METHODS: U...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29161158/drug-use-and-incarceration-among-rural-appalachian-women-findings-from-a-jail-sample
#16
Michele Staton, Gabriele Ciciurkaite, Carrie Oser, Martha Tillson, Carl Leukefeld, J Matthew Webster, Jennifer R Havens
BACKGROUND/OBJECTIVE: The purpose of this paper is to examine drug use and incarceration history among rural Appalachian women. METHODS: This study involved random selection, screening, and interviews with rural women from local jails in Appalachia. RESULTS: Of the women randomly selected and screened, 97% met criteria for substance use intervention. Significant factors associated with incarceration history included age, education, custody status, and mental health...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29160960/risk-of-past-year-injury-related-to-hours-of-exposure-to-an-elevated-bac-and-average-monthly-alcohol-volume-data-from-four-national-alcohol-surveys-2000-2015
#17
Cheryl J Cherpitel, Yu Ye, William C Kerr
BACKGROUND: While a strong association exists between alcohol and injury in emergency department (ED) studies, these studies are not representative of the general population. OBJECTIVE: The association of injury with the number of hours of exposure to a BAC ≥ 0.05 and average monthly volume in drinks, both based on self-report of quantity and frequency of drinking in the last year, in a merged sample of respondents (n=29,571) from four U.S. National Alcohol Surveys (2000-2015) is analyzed...
November 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29160909/revisiting-chronic-rejection-following-living-donor-liver-transplantation-in-the-tacrolimus-era-a-single-centre-experience
#18
Narendra Singh Choudhary, Neeraj Saraf, Sanjiv Saigal, Dheeraj Gautam, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Thiagrajan Srinivasan, Sanjay Kumar Yadav, Arvinder Soin
BACKGROUND AND AIMS: Chronic rejection (CR) is an uncommon but important cause of graft dysfunction, leading to graft loss and often requires re-transplantation. This study evaluates the incidence and outcome of patients with CR at a large living donor liver transplant (LDLT) centre. METHODS: Data of patients with CR was retrospectively analyzed in 1232 adult (age >18 years) LDLT on Tacrolimus (mainly) based immunosuppression. Sirolimus/Everolimus (mTOR inhibitors) were added to baseline immunosuppression as rescue therapy in patients with CR...
November 21, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29160901/dietary-advanced-glycation-end-products-have-sex-and-age-dependent-effects-on-vertebral-bone-microstructure-and-mechanical-function-in-mice
#19
Svenja Illien-Jünger, Paolo Palacio-Mancheno, William F Kindschuh, Xue Chen, Grazyna E Sroga, Deepak Vashishth, James C Iatridis
Back pain is a leading cause of global disability that can arise from vertebral fracture and osteoporosis. While poor general health and obesity are among the strongest risk factors for back pain, there is remarkably little known about how diet influences spinal diseases. Advanced glycation endproducts (AGEs) are implicated in increased fracture risk, yet no studies investigated how dietary AGEs affect spinal health. We tested the hypothesis that high dietary AGE ingestion will diminish vertebral structure and function in a sex- and age-dependent manner...
November 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29160725/management-of-neurologic-deformity-of-the-ankle-and-foot-with-concurrent-osteomyelitis-with-the-ilizarov-method
#20
Nikolay Mikhailovich Kliushin, Anatoliy Sergeyevich Sudnitsyn, Koushik Narayan Subramanyam, Jefferson George
BACKGROUND: The combination of neurologic deformity of the ankle and foot with osteomyelitis is a therapeutic challenge. We investigated the role of Ilizarov with regard to eradication of infection, correction of deformities and improvement of patient function. METHODS: We retrospectively reviewed 77 patients (77 feet) with neurologic deformity of the ankle and foot with osteomyelitis treated sequentially in 3 stages by Ilizarov method. The 3 stages were (1) active debridement and Ilizarov stabilization, (2) further strengthening of Ilizarov fixator and active osteosynthesis consisting of strategies like arthrodesis, osteotomy distraction, bone transport, or combination thereof, (3) consolidation of fusion/regeneration achieved in second stage...
November 1, 2017: Foot & Ankle International
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