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Pleural plaques

P Fallahi, F Ragusa
Recently it has been shown that interferon (IFN)-γ plays an important role in mesothelioma, mediated by the main IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ- induced protein 10 (IP-10). IP-10 is up-regulated in malignant mesothelioma (MM), suggesting a relationship with development of these tumors. Nanoparticles containing nickel, that increase the risk for pleural diseases, induced increased levels of IP-10 in rat pleural mesothelial cells. Chemokine (C-X-C motif) receptor (CXCR)3 expression in CD4(+) T cells from pleural plaques and MMs was significantly decreased compared with that from healthy donors suggesting that CXCR3, IFN-γ, and IP-10 may be candidates to detect and monitor disease status...
November 2016: La Clinica Terapeutica
Suni Lee, Hidenori Matsuzaki, Megumi Maeda, Shoko Yamamoto, Naoko Kumagai-Takei, Tamayo Hatayama, Miho Ikeda, Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki
Asbestos exposure causes malignant tumors such as lung cancer and malignant mesothelioma. Based on our hypothesis in which continuous exposure to asbestos of immune cells cause reduction of antitumor immunity, the decrease of natural killer cell killing activity with reduction of NKp46 activating receptor expression, inhibition of cytotoxic T cell clonal expansion, reduced CXCR3 chemokine receptor expression and production of interferon-γ production in CD4+ T cells were reported using cell line models, freshly isolated peripheral blood immune cells from health donors as well as asbestos exposed patients such as pleural plaque and mesothelioma...
January 2017: International Journal of Oncology
Caterina Ledda, Carla Loreto, Serena Matera, Nicoletta Massimino, Emanuele Cannizzaro, Andrea Musumeci, Marcello Migliore, Concettina Fenga, Cristoforo Pomara, Venerando Rapisarda
Fluoro-edenite (FE) is a natural mineral asbestos-like fibrous species first isolated in Biancavilla, Sicily. In order to clarify potential involvement of IL-18 in the pathogenesis of FE-induced chest abnormalities, we analyzed IL-18 serum levels in FE-exposed workers (FEEW) and correlated them with pleural and parenchymal abnormalities. A total of 21 FEEWs, residing in Biancavilla for >30 years, with a working seniority of 17 ± 6.1 years were examined. High-resolution computed tomography scans revealed low grade of fibrosis in 8 (38%) FEEWs, and pleural plaques (PPs) in 13 (62%) FEEWs...
December 2016: Future Oncology
Caterina Ledda, Carla Loreto, Massimo Bracci, Dario Mangano, Marcello Migliore, Vincenzo Ricceri, Andrea Musumeci, Chiara Costa, Cristoforo Pomara, Venerando Rapisarda
Fluoro-edenite is a natural mineral species first isolated in Biancavilla, Sicily, used for construction of houses and roads, with health effects allegedly the same as those of asbestos. The aim of the current study was to evaluate the risks of pleural plaques and parenchymal abnormalities in women living in Biancavilla through a retrospective cross-sectional study. The evaluation pointed out a relative risk of pleural plaques of 39.67 (95% CI: 11.33-138.82) and 27.67 (95% CI: 5.43-141.00) for parenchymal abnormalities as well...
December 2016: Future Oncology
Kana Hashimoto, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima
BACKGROUND: Desmoplastic malignant pleural mesothelioma (DMM) is rare histological subtype of diffuse malignant pleural mesothelioma (MPM), accounting for 5-10 % of cases. It has a poor prognosis, with direct invasion of the chest wall or lungs and distant metastases. Its pathological characteristics include dense collagen fibers in a storiform pattern. Its pretreatment pathological diagnosis is difficult, with fibrous pleuritis and reactive mesothelial hyperplasia as potential differential diagnoses...
2016: BMC Cancer
Ke Zu, Ge Tao, Julie E Goodman
BACKGROUND: In the 2014 Integrated Risk Information System (IRIS) assessment for Libby amphibole asbestos (LAA), US EPA calculated a reference concentration (RfC) based on the prevalence of pleural plaques in a group of vermiculite workers in Marysville, Ohio. This RfC is based on the assumption that pleural plaques are associated with adverse lung function. In this study, we evaluated the association between pleural plaques and lung function in the Marysville worker cohort to determine whether they are associated with adverse effects or, rather, are more likely a biomarker of cumulative exposure to LAA...
September 2016: Inhalation Toxicology
Valerie Nuyts, Hadewijch Vanhooren, Sarah Begyn, Kristiaan Nackaerts, Benoit Nemery
OBJECTIVES: Asbestos bodies (AB) in bronchoalveolar lavage (BAL) can be detected by light microscopy and their concentration is indicative of past cumulative asbestos exposure. We assessed clinical and exposure characteristics, as well as possible time trends, among patients in whom AB had been quantified in BAL. METHODS: BAL samples obtained from 578 participants between January 1997 and December 2014 were available for analysis. The processing of samples and the microscopic analysis were performed by a single expert and 76% of samples came from a single tertiary care hospital, allowing clinical and exposure data to be extracted from patient files...
January 2017: Occupational and Environmental Medicine
Katsuya Kato, Kenichi Gemba, Nobukazu Fujimoto, Keisuke Aoe, Yukio Takeshima, Kouki Inai, Takumi Kishimoto
OBJECTIVE: To elucidate differences in the level and localization of pleural irregularities in early malignant pleural mesothelioma (eMPM) and benign asbestos pleural effusion (BAPE) using CT. STUDY DESIGN: Retrospective assessment of CT findings of consecutive patients with BAPE at a single centre and patients with eMPM reported in Japanese vital statistics. METHODOLOGY: Thirty-six patients with confirmed diagnoses of BAPE and sixty-six patients with confirmed diagnoses of eMPM (mesothelioma stages T1 or T2) were included...
September 2016: European Journal of Radiology
David DeLapp, Christopher Chan, Perry Nystrom
Mesothelioma is a rare pulmonary malignancy commonly associated with asbestos exposure. Its presentation is insidious and non-specific, with complaints of chest pain, dyspnea and cough. Chest X-ray may demonstrate unilateral pleural effusion. CT and PET scans may highlight nodular pleural plaques. Diagnosis often times is difficult with negative imaging and negative pleural fluid studies. In rare cases, hydropneumothoraces may be seen. We report a case of malignant pleural mesothelioma presenting as recurrent hydropneumothorax with negative CT scan of the chest for pleural abnormalities and negative pleural fluid studies...
2016: Respiratory Medicine Case Reports
Pietro Gino Barbieri, Anna Benedetta Sommigliana
BACKGROUND: Asbestos-related diseases among shipyard workers are well known in Italy but descriptive long-term studies are limited; asbestos has been extensively used but the past exposure intensity has never been estimated because data from environmental and biological monitoring are almost absent. OBJECTIVES: To describe the asbestos-related dis-eases (1996-2015) diagnosed among shipbuilding workers from a very important shipyard in Northern Italy, and to assess past asbestos exposure levels by cumulative dose indices, fibres and asbestos bodies...
2016: La Medicina del Lavoro
Yoon Kyung Kim, Jeung Sook Kim, Kyung Won Lee, Chin A Yi, Jin Mo Koo, Soon-Hee Jung
OBJECTIVE: To compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic pleural disease (MPD). MATERIALS AND METHODS: The authors reviewed the MDCT images of 167 patients, 103 patients with MPM and 64 patients with MPD. All 167 cases were pathologically confirmed by sonography-guided needle biopsy of pleura, thoracoscopic pleural biopsy, or open thoracotomy. CT features were evaluated with respect to pleural effusion, pleural thickening, invasion of other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume decrease, asbestosis, and the presence of pleural plaque...
July 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Conor P Murray, Patrick M Wong, Joelin Teh, Nick de Klerk, Tim Rosenow, Helman Alfonso, Alison Reid, Peter Franklin, A W Bill Musk, Fraser J H Brims
BACKGROUND AND OBJECTIVE: Computed tomography (CT)-based studies of asbestos-exposed individuals report a high prevalence of lung cancer, but the utility of low dose CT (LDCT) to screen asbestos-exposed populations is not established. We aimed to describe the prevalence of indeterminate pulmonary nodules and incidental findings on chest LDCT of asbestos-exposed subjects in Western Australia. METHODS: A total of 906 subjects from the Western Australian Asbestos Review Programme underwent LDCT of the chest as part of regular annual review...
June 16, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Biswanath Behera, Laxmisha Chandrashekar, Devinder Mohan Thappa, Pampa Ch Toi, Kolar Vishwanath Vinod
AIDS-associated disseminated Kaposi sarcoma (KS) is a rare entity, especially in India due to the low prevalence of human herpes virus-8 infections in Indian population. Due to its rapid and progressive nature, early diagnosis and institution of highly active antiretroviral therapy is crucial in AIDS-associated KS, with a view to achieving favorable prognosis. We report a case of disseminated KS in an HIV-1 positive patient, who presented with two months history of multiple violaceous patches and plaques over the trunk, bilateral upper limbs, lower limbs, and hard palate...
May 2016: Indian Journal of Dermatology
Gustaaf G de Ridder, Alyssa Kraynie, Elizabeth N Pavlisko, Tim D Oury, Victor L Roggli
Lung tissue from 42 peritoneal mesothelioma cases was analyzed by light microscopy and scanning electron microscopy/energy dispersive spectrometry. There were 34 men and 8 women with a mean age of 61 ± 10 years. Also, 17% of cases had histologically confirmed asbestosis, and 26% had only parietal pleural plaques. The asbestos body count exceeded our normal range in 22 of 42 cases (52%). Cases with asbestos-related pulmonary disease had higher fiber burdens than those without. The vast majority of fibers were commercial amphiboles (amosite with lesser amounts of crocidolite)...
May 2016: Ultrastructural Pathology
Caterina Ledda, Cristoforo Pomara, Massimo Bracci, Dario Mangano, Vincenzo Ricceri, Andrea Musumeci, Margherita Ferrante, Giuseppe Musumeci, Carla Loreto, Concettina Fenga, Lory Santarelli, Venerando Rapisarda
Natural carcinogenic fibers are asbestos and asbestiform fibers present as a natural component of soils or rocks. These fibers are released into the environment resulting in exposure of the general population. Environmental contamination by fibers are those cases occurred in: rural regions of Turkey, in Mediterranean countries and in other sites of the world, including northern Europe, USA and China. Fluoro-edenite(FE) is a natural mineral species first isolated in Biancavilla, Sicily. The fibers are similar in size and morphology to some amphibolic asbestos fibers, whose inhalation can cause chronic inflammation and cancer...
October 2016: Environmental Research
P P Song, Y Wang, J L Sun, Y Gao, J Liu, Y X Chen
OBJECTIVE: It can provide statistics reference for the prevention and treatment by analysising the status and characteristics related to the asbestos disease of an asbestos products enterprises from 1988 to 2014. METHODS: We have collected the data concerning the case of asbestos-related disease between 1988 and 2014, then the data were arranged, collecteted and analyzed using statistical method. RESULTS: The total of patients is 625 (male: 225, female: 400)...
March 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Sarah Lopatin, Jun-Chieh Tsay, Doreen Addrizzo-Harris, John S Munger, Harvey Pass, William N Rom
No abstract text is available yet for this article.
May 2016: American Journal of Industrial Medicine
Melike Demir, Halide Kaya, Mahsuk Taylan, Aysun Ekinci, Sureyya Yılmaz, Fatma Teke, Cengizhan Sezgi, Abdullah Cetin Tanrikulu, Fatih Meteroglu, Abdurrahman Senyigit
INTRODUCTION: The purpose of this study was to investigate the potential value of certain biomarkers in predicting the presence of malignant pleural mesothelioma (MPM) in individuals environmentally exposed to asbestos. METHODS: This prospective study investigated three groups; a control group composed of 41 healthy subjects, an asbestos exposure group consisting of 48 individuals, and a MPM group consisting of 42 patients. Serum levels of soluble mesothelin-related peptide (SMRP), thioredoxin-1 (TRX), epidermal growth factor receptor (EGFR), fibulin-3, syndecan-1 (SDC-1), and mesothelin were determined...
June 2016: Lung
Katsuya Kato, Kenichi Gemba, Nobukazu Fujimoto, Keisuke Aoe, Yukio Takeshima, Kouki Inai, Takumi Kishimoto
PURPOSE: The purpose of this study was to clarify the characteristic findings of mesothelioma at the time of diagnosis, and determine precautions and guidelines for diagnosing mesothelioma early in imaging studies. MATERIALS AND METHODS: Overall, 327 patients with pleural mesothelioma were selected from 6030 patients who died of mesothelioma between 2003 and 2008 in Japan. Their imaging findings were examined retrospectively. RESULTS: Plaques were found in 35 % of computed tomography (CT) scans...
June 2016: Japanese Journal of Radiology
Katsuya Kato, Kenichi Gemba, Nobukazu Fujimoto, Keisuke Aoe, Yukio Takeshima, Kouki Inai, Takumi Kishimoto
AIM: The objective of this study was to determine the computed tomographic (CT) features of malignant peritoneal mesothelioma (MPM). PATIENTS AND METHODS: We analyzed CT features of MPM cases and compared them to those of other malignant conditions (non-MPM). RESULTS: Multiple nodular lesions occurred more frequently in the MPM group compared to non-MPM cases (p=0.013). Thickening of the mesentery was detected more frequently in MPM cases than in non-MPM cases (56% vs...
March 2016: Anticancer Research
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