keyword
MENU ▼
Read by QxMD icon Read
search

Pleural plaques

keyword
https://www.readbyqxmd.com/read/28707542/the-physiological-consequences-of-different-distributions-of-diffuse-pleural-thickening-on-ct-imaging
#1
Duneesha de Fonseka, Anthony Edey, Louise Stadon, Jason Viner, Michael Darby, Nick A Maskell
OBJECTIVES: Diffuse pleural thickening refers to extensive visceral pleural fibrosis, with adhesion formation to the parietal pleura, obliterating the pleural space. The radiological definition of DPT remains controversial with most literature requiring the presence of an obliterated costophrenic angle for defining DPT. We conducted a study to investigate the variable distributions of DPT and associated lung function deficit. METHODS: Eighty-five patients referred to a pleural clinic with suspected pleural thickening were screened for our study...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28686522/asbestos-related-disease-in-upholsterers
#2
M J Cruz, J Sampol, M Pallero, E Rodríguez, J Ferrer
Before its use was banned in developed countries, asbestos was widely applied in upholstery. However, the risk of asbestos diseases among upholsterers has only rarely been reported. In this case series, we present a first series of 6 workers employed in small workshops who developed several asbestos-related diseases, including pleural plaques, pleural fibrosis, and asbestosis. Exposures were intermittent and difficult to quantify, but lung asbestos content assessed by bronchoalveolar lavage was high in the 3 patients evaluated...
July 7, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28656146/incidental-and-underreported-pleural-plaques-at-chest-ct-do-not-miss-them-asbestos-exposure-still-exists
#3
Maria Antonietta Mazzei, Francesco Contorni, Francesco Gentili, Susanna Guerrini, Francesco Giuseppe Mazzei, Antonio Pinto, Nevada Cioffi Squitieri, Antonietta Gerardina Sisinni, Valentina Paolucci, Riccardo Romeo, Pietro Sartorelli, Luca Volterrani
Pleural plaques (PPs) may be a risk factor for mortality from lung cancer in asbestos-exposed workers and are considered to be a marker of exposure. Diagnosing PPs is also important because asbestos-exposed patients should be offered a health surveillance that is mandatory in many countries. On the other hand PPs are useful for compensation purposes. In this study we aimed to evaluate the prevalence, as incidental findings, and the underreporting rate of PPs in chest CT scans (CTs) performed in a cohort of patients (1512) who underwent chest CT with a slice thickness no more than 1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28641716/the-effects-of-pleural-plaques-on-longitudinal-lung-function-in-vermiculite-miners-of-libby-montana
#4
Kathleen A Clark, J Jay Flynn, Wilfried J J Karmaus, Lawrence C Mohr
BACKGROUND: This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor >1cm in diameter...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28558669/calretinin-as-a-blood-based-biomarker-for-mesothelioma
#5
Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W Musk, Bruce W S Robinson, Thomas Brüning, Jenette Creaney
BACKGROUND: Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbestos. Secondary prevention has been established to provide persons at risk regular health examinations. An earlier detection with tumor markers might improve therapeutic options. Previously, we have developed a new blood-based assay for the protein marker calretinin. Aim of this study was the verification of the assay in an independent study population and comparison with the established marker mesothelin...
May 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28515054/longitudinal-decline-in-lung-function-among-older-construction-workers
#6
John M Dement, Laura S Welch, Knut Ringen, Kim Cranford, Patricia Quinn
BACKGROUND: Occupational exposures to vapours, gasses, dusts and fumes (VGDF) and chest X-ray abnormalities by the International Labour Office (ILO) classification system are associated with reduced lung function, with the majority of published studies being cross-sectional. We examined the effects of VGDF exposures, as well as ILO parenchymal changes, pleural plaque and diffuse pleural thickening (DPT) on reduction in lung function in a longitudinal study. METHODS: Chest radiographs and spirometry for 3150 ageing construction workers enrolled in a medical screening programme with a baseline and at least one follow-up examination were studied...
May 17, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28498408/induction-of-il-17-production-from-human-peripheral-blood-cd4-cells-by-asbestos-exposure
#7
Megumi Maeda, Ying Chen, Suni Lee, Naoko Kumagai-Takei, Kei Yoshitome, Hidenori Matsuzaki, Shoko Yamamoto, Tamayo Hatayama, Miho Ikeda, Yasumitsu Nishimura, Takemi Otsuki
We have previously reported that chronic, recurrent and low-dose exposure to asbestos fibers causes a reduction in antitumor immunity. Investigation of natural killer (NK) cells using an in vitro cell line model and comprising in vitro activation using freshly isolated NK cells co-cultured with chrysotile fibers, as well as NK cells derived from asbestos-exposed patients with pleural plaque (PP) or malignant mesothelioma (MM), revealed decreased expression of NK cell activating receptors such as NKG2D, 2B4 and NKp46...
May 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28491491/tuberculous-pleural-effusion-occurring-concurrently-with-asbestos-related-pleural-disease
#8
Massa Zantah, Debapriya Datta
An eighty-four-year-old man presented with progressive exertional dyspnea, productive cough and weight loss for two months. His physical exam was notable for diminished breath sounds at the right base, with dullness to percussion. Chest-x-ray showed moderate right-sided pleural effusion and bilateral calcified pleural plaques as well as diaphragmatic plaques consistent with asbestos-related pleural disease (ARPD). Pleural fluid was exudative with predominantly mononuclear cells, negative acid fast bacilli stain, negative cultures, and negative cytology for malignant cells...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28468931/pleural-abnormalities-in-the-framingham-heart-study-prevalence-and-ct-image-features
#9
Tetsuro Araki, Masahiro Yanagawa, Fangui Jenny Sun, Josée Dupuis, Mizuki Nishino, Yoshitake Yamada, George R Washko, David C Christiani, Noriyuki Tomiyama, George T O'Connor, Gary M Hunninghake, Hiroto Hatabu
BACKGROUND: The prevalence of pleural abnormalities in the general population is an epidemiologically important index of asbestos exposure, which has not been investigated since a radiography-based study in 1980. METHODS: We examined 2633 chest CT scans (mean 59.2 years, 50% female) from the Framingham Heart Study (FHS) for the presence and image characteristics of pleural plaques and diffuse pleural thickening. Demographics and pulmonary function were stratified by the presence of pleural abnormalities in association with interstitial lung abnormalities...
May 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28395242/analysis-of-fibulin-3-after-exposure-to-asbestos-like-fibers
#10
Venerando Rapisarda, Rosario Caltabiano, Giuseppe Musumeci, Paola Castrogiovanni, Margherita Ferrante, Caterina Ledda, Claudia Lombardo, Adriana Carol Eleonora Graziano, Venera Cardile, Carla Loreto
A significantly increased incidence of malignant mesothelioma in Biancavilla (Sicily, Italy) has been ascribed to exposure to fluoro-edenite, a fibrous amphibole extracted from a local stone quarry. Fibulin-3 is a highly conserved glycoprotein proposed as a biomarker for malignant mesothelioma that belongs to the family of extracellular matrix proteins. Previous studies demonstrated high Fibulin-3 plasma levels in workers with pleural plaques exposed to fluoro-edenite. Therefore, in order to gain insight into the biomolecular mechanisms of fluoro-edenite toxicity, we performed the analysis of Fibulin-3 expression by immunohistochemistry in the lung samples derived from sheep belonging to the area of Biancavilla...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28388964/breast-and-pleuropulmonary-metastasis-of-multirecurrent-scalp-dermatofibrosarcoma-protuberans-a-case-report
#11
N-A Ouédraogo Nde, N A Ouédraogo, H A Bambara, B M A Tiemtoré-Kambou, F Traoré, N Zongo, M S Ouédraogo, G P Tapsoba, Achach Thouraya Chtioui, A Lamien/Sanou
BACKGROUND: Dermatofibrosarcoma protuberans is a rare tumor, representing about 0.1% of skin malignant tumors. It is characterized by local aggressiveness with significant potential for recurrence. Although metastasis is rare, it does occur. We report a case of a Burkinabe woman with dermatofibrosarcoma protuberans. CASE PRESENTATION: A 27-year-old Burkinabe woman consulted our institution for a recurrent scalp nodule that had been evolving for 13 years. At clinical examination, she was in good condition with a dry cough...
April 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28348451/serum-hmgb1-as-a-potential-biomarker-for-patients-with-asbestos-related-diseases
#12
Shibo Ying, Zhaoqiang Jiang, Xianglei He, Min Yu, Riping Chen, Junqiang Chen, Guoqing Ru, Yuan Chen, Wanyuan Chen, Lijin Zhu, Tao Li, Yixiao Zhang, Xinnian Guo, Xianhong Yin, Xing Zhang, Jianlin Lou
High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders and cancers. Notably, HMGB1 is a potential therapeutic target and novel biomarker in related diseases. However, the diagnostic value of HMGB1 for benign and malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum HMGB1 levels in Chinese asbestos-exposed (AE) and ARDs populations and further evaluated the diagnostic value of HMGB1 in patients with certain types of ARDs, including those with pleural plaques, asbestosis, or malignant mesothelioma (MM)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28330426/comment-on-pleural-plaques-and-lung-function-in-the-marysville-worker-cohort-a-re-analysis-by-zu-et%C3%A2-al-2016
#13
James E Lockey, Kari Dunning, Timothy J Hilbert, Eric Borton, Linda Levin, Carol H Rice, Roy T McKay, Ralph Shipley, Cristopher A Meyer, Charles Perme, Grace K LeMasters
No abstract text is available yet for this article.
February 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28316141/dasatinib-inhibits-actin-fiber-reorganization-and-promotes-endothelial-cell-permeability-through-rhoa-rock-pathway
#14
Swapan K Dasgupta, Anhquyen Le, K Vinod Vijayan, Perumal Thiagarajan
Treatment with dasatinib, a tyrosine kinase inhibitor, is associated with edema, pleural effusion, and pulmonary edema. We investigated the effect of dasatinib on the barrier function of human microvascular endothelial cells-1 (HMEC-1) in vitro and in vivo. The permeability of HMEC-1 to fluorescein isothiocyante (FITC)-dextran increased in Transwell chambers within 5 min following the addition of therapeutic concentrations of dasatinib. The change in permeability was associated with increased activation of RhoA GTPase and its effector Rho-associated coiled-coil kinase 1(ROCK1)...
April 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28284315/long-term-outcome-of-patients-with-nonspecific-pleurisy-at-medical-thoracoscopy
#15
Yuan Yang, Yan-Bing Wu, Zhen Wang, Xiao-Juan Wang, Li-Li Xu, Zhao-Hui Tong, Huan-Zhong Shi
BACKGROUND: Medical thoracoscopy is an effective and safe procedure for diagnosing pleural effusions of undetermined causes. But there are still a part of patients with pleural effusions were diagnosed as nonspecific pleurisy when no specific biopsy results were found after undergoing thoracoscopic biopsy. The long-term outcome of these patients is unclear, and anxieties about undiagnosed malignancy persist. METHODS: Between July 2005 and June 2014, medical thoracoscopy using the semi-rigid instrument was performed and pleural biopsy was taken in 833 patients with pleural effusions...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28272659/non-hodgkin-lymphoma-and-pleural-mesothelioma-in-a-person-exposed-to-asbestos
#16
Claudio Bianchi, Tommaso Bianchi
Non-Hodgkin lymphoma and pleural mesothelioma may co-exist in the same patient. A large cell non-Hodgkin lymphoma of the inguinal lymph nodes was diagnosed in a 73-year-old woman. The patient was treated by chemotherapy. She did not receive radiotherapy. The patient had been exposed to asbestos having worked in a cotton mill and in a distillery. Four years after the diagnosis of lymphoma, she presented with a left pleural effusion. Large biopsies of the pleura showed a malignant mesothelioma, biphasic type, and pleural plaques...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28271362/mesothelioid-reaction-following-talc-pleurodesis-a-case-report
#17
Tatyana Faynberg, Neha Patel, Amrit P Nayar, Alan J Shienbaum
INTRODUCTION: Talc pleurodesis is a well-established procedure performed to obliterate the pleural space to prevent recurrent pleural effusion and/or recurrent pneumothorax. Pleurodesis is commonly accomplished by draining the pleural fluid, if present, followed by either a mechanical procedure, such as abrasion, pleurectomy, or instillation of a chemical irritant into the pleural space, which results in inflammation and fibrosis which obliterates the pleural space. The reported complications of talc pleurodesis are hypoxemia, hypotension, tachycardia, dyspnea, chest pain, and fever...
March 7, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28051835/mesothelioma-and-interferon-%C3%AE-dependent-chemokine-ip-10
#18
P Fallahi, F Ragusa
Recently it has been shown that interferon (IFN)-γ plays an important role in mesothelioma, mediated by the main IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ- induced protein 10 (IP-10). IP-10 is up-regulated in malignant mesothelioma (MM), suggesting a relationship with development of these tumors. Nanoparticles containing nickel, that increase the risk for pleural diseases, induced increased levels of IP-10 in rat pleural mesothelial cells. Chemokine (C-X-C motif) receptor (CXCR)3 expression in CD4(+) T cells from pleural plaques and MMs was significantly decreased compared with that from healthy donors suggesting that CXCR3, IFN-γ, and IP-10 may be candidates to detect and monitor disease status...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27878235/accelerated-cell-cycle-progression-of-human-regulatory-t%C3%A2-cell-like-cell-line-caused-by-continuous-exposure-to-asbestos-fibers
#19
Suni Lee, Hidenori Matsuzaki, Megumi Maeda, Shoko Yamamoto, Naoko Kumagai-Takei, Tamayo Hatayama, Miho Ikeda, Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki
Asbestos exposure causes malignant tumors such as lung cancer and malignant mesothelioma. Based on our hypothesis in which continuous exposure to asbestos of immune cells cause reduction of antitumor immunity, the decrease of natural killer cell killing activity with reduction of NKp46 activating receptor expression, inhibition of cytotoxic T cell clonal expansion, reduced CXCR3 chemokine receptor expression and production of interferon-γ production in CD4+ T cells were reported using cell line models, freshly isolated peripheral blood immune cells from health donors as well as asbestos exposed patients such as pleural plaque and mesothelioma...
January 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27669761/early-effects-of-fluoro-edenite-correlation-between-il-18-serum-levels-and-pleural-and-parenchymal-abnormalities
#20
Caterina Ledda, Carla Loreto, Serena Matera, Nicoletta Massimino, Emanuele Cannizzaro, Andrea Musumeci, Marcello Migliore, Concettina Fenga, Cristoforo Pomara, Venerando Rapisarda
Fluoro-edenite (FE) is a natural mineral asbestos-like fibrous species first isolated in Biancavilla, Sicily. In order to clarify potential involvement of IL-18 in the pathogenesis of FE-induced chest abnormalities, we analyzed IL-18 serum levels in FE-exposed workers (FEEW) and correlated them with pleural and parenchymal abnormalities. A total of 21 FEEWs, residing in Biancavilla for >30 years, with a working seniority of 17 ± 6.1 years were examined. High-resolution computed tomography scans revealed low grade of fibrosis in 8 (38%) FEEWs, and pleural plaques (PPs) in 13 (62%) FEEWs...
December 2016: Future Oncology
keyword
keyword
26923
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"