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https://www.readbyqxmd.com/read/29419731/inflammatory-alteration-of-human-t-cells-exposed-continuously-to-asbestos
#1
REVIEW
Naoko Kumagai-Takei, Shoko Yamamoto, Suni Lee, Megumi Maeda, Hidenori Masuzzaki, Nagisa Sada, Min Yu, Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki
Asbestos is a known carcinogen and exposure can lead to lung cancer and malignant mesothelioma. To examine the effects of asbestos fibers on human immune cells, the human T cell leukemia/lymphoma virus (HTLV)-1 immortalized human T cell line MT-2 was employed. Following continuous exposure to asbestos fibers for more than eight months, MT-2 sublines showed acquisition of resistance to asbestos-induced apoptosis with decreased death signals and increased surviving signals. These sublines showed various characteristics that suggested a reduction in anti-tumor immunity...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29386888/predictors-of-pneumonia-on-routine-chest-radiographs-in-patients-with-copd-a-post-hoc-analysis-of-two-1-year-randomized-controlled-trials
#2
David B Rubin, Harris A Ahmad, Michael O'Neal, Sophie Bennett, Sally Lettis, Dmitry V Galkin, Courtney Crim
Background: Patients with COPD are at risk for life-threatening pneumonia. Although anatomical abnormalities in the thorax may predispose to pneumonia, those abnormalities identified on routine chest X-rays (CXRs) in patients with COPD have not been studied to better understand pneumonia risk. Methods: We conducted a post hoc exploratory analysis of data from two replicate year-long clinical trials assessing the impact of fluticasone furoate-vilanterol versus vilanterol alone on COPD exacerbations (GSK studies: HZC102871/NCT01009463 and HZC102970/NCT01017952)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29355487/mesothelioma-with-a-large-prevascular-lymph-node-n1-involvement-or-something-different
#3
Lawek Berzenji, Paul E Van Schil, Annemie Snoeckx, Marjan Hertoghs, Laurens Carp
A 64-year-old man presented with a large amount of right-sided pleural fluid upon imaging, together with calcified pleural plaques and an enlarged nodular structure in the prevascular mediastinum, presumably an enlarged lymph node. Pleural biopsies were obtained during video-assisted thoracoscopic surgery to exclude malignancy. Histopathology showed an epithelial malignant pleural mesothelioma. Induction chemotherapy with cisplatin/pemetrexed was administered followed by an extended pleurectomy/decortication with systematic nodal dissection...
January 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29344253/diagnostic-value-of-medical-thoracoscopy-in-malignant-pleural-effusion-induced-by-non-hodgkin-s-lymphoma
#4
Zhen Wang, Yan-Bing Wu, Li-Li Xu, Mu-Lan Jin, Xiao-Li Diao, Xiao-Juan Wang, Zhao-Hui Tong, Huan-Zhong Shi
Malignant pleural effusion (MPE) appears in up to 20% of patients with non-Hodgkin's lymphoma (NHL). The present study aimed to assess the efficacy of medical thoracoscopy (MT) in the diagnosis of patients with MPE induced by NHL. Between July 2005 and June 2014, 833 patients with pleural effusions of unknown etiology underwent MT in Beijing Chaoyang Hospital (Beijing, China), where diagnostic thoracocentesis or/and blind pleural biopsy had failed to yield an answer. Demographic, radiographic, thoracoscopic, histological and immunophenotyping data of 10 NHL patients with MPE were then retrospectively analyzed...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29306869/biological-responses-to-asbestos-inhalation-and-pathogenesis-of-asbestos-related-benign-and-malignant-disease
#5
Eduardo Solbes, Richart W Harper
Asbestos comprises a group of fibrous minerals that are naturally occurring in the environment. Because of its natural properties, asbestos gained popularity for commercial applications in the late 19th century and was used throughout the majority of the 20th century, with predominant use in the construction, automotive, and shipbuilding industries. Asbestos has been linked to a spectrum of pulmonary diseases, such as pleural fibrosis and plaques, asbestosis, benign asbestos pleural effusion, small cell lung carcinoma, non-small cell lung carcinoma, and malignant mesothelioma...
January 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29241379/prevalence-of-anti-nuclear-autoantibodies-in-subjects-exposed-to-natural-asbestiform-fibers-a-cross-sectional-study
#6
Caterina Ledda, Rosario Caltabiano, Carla Loreto, Diana Cinà, Paola Senia, Andrea Musumeci, Vincenzo Ricceri, Cristoforo Pomara, Venerando Rapisarda
Fluoro-edenite (FE) is an asbestiform mineral fiber spotted in the lava rocks excavated from a stone quarry in Biancavilla (Italy). The derived material had been employed locally for building purposes. Previous studies found evidence that exposure to asbestos may induce autoimmunity, with frequency of anti-nuclear autoantibodies (ANA). The aim of this study was to explore the relationship between FE exposure and autoimmune responses in an exposed population. For the study, 60 subjects living in the area of Biancavilla and 60 subjects as control group were randomly invited to participate...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29241302/complications-of-chest-drain-insertion-in-a-patient-with-pleural-plaques
#7
Hariette Goldman, Scott Jennings, Peter W Grant
No abstract text is available yet for this article.
December 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29200597/plasma-fibulin-3-as-a-potential-biomarker-for-patients-with-asbestos-related-diseases-in-the-han-population
#8
Zhaoqiang Jiang, Shibo Ying, Wei Shen, Xianglei He, Junqiang Chen, Hailing Xia, Min Yu, Yun Xiao, Lingfang Feng, Lijin Zhu, Li Ju, Xinnian Guo, Yixiao Zhang, Jia-Wei Shen, Yan Tong, Xing Zhang, Jianlin Lou
Fibulin-3 has been reported as a potential biomarker for mesothelioma. However, little is known about the diagnostic efficacies of fibulin-3 for asbestos-related diseases (ARDs) in China. This study was to investigate the utility of fibulin-3 for asbestos exposure and ARDs. A total of 430 subjects were recruited from Southeast China, including healthy individuals, asbestos-exposed (AE) individuals, and patients with pleural plaques (PP), asbestosis, and malignant pleural mesothelioma (MPM). Plasma fibulin-3 was measured using the enzyme-linked immunosorbent assay...
2017: Disease Markers
https://www.readbyqxmd.com/read/29178853/pleural-plaques-in-lung-cancer-screening-by-low-dose-computed-tomography-prevalence-association-with-lung-cancer-and-mortality
#9
Mario Silva, Nicola Sverzellati, Davide Colombi, Gianluca Milanese, Carlo La Vecchia, Carlotta Galeone, Alfonso Marchianò, Ugo Pastorino
BACKGROUND: To report the prevalence of pleural plaques in a lung cancer screening trial by low-dose computed tomography (LDCT) and to test the association with incidence of lung cancer and mortality. METHODS: The LDCT of 2303 screenees were retrospectively reviewed with the specific aim of describing the prevalence and features of pleural plaques. Self-administered questionnaire was used to assess asbestos exposure. Frequency of lung cancer, lung cancer mortality, and overall mortality were detailed according to presence of pleural findings...
November 25, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29124658/atypical-hrct-manifestations-of-pulmonary-sarcoidosis
#10
Diletta Cozzi, Elena Bargagli, Alessandro Giuseppe Calabrò, Elena Torricelli, Federico Giannelli, Edoardo Cavigli, Vittorio Miele
PURPOSE: To present our experience of cases of pulmonary sarcoidosis with atypical HRCT patterns found during 2016 focusing on the differential diagnosis to contribute to the difficult role of the radiologist in the disease identification and to help the clinicians to reach the diagnosis. MATERIALS AND METHODS: The HRCT examinations of 47 patients with sarcoidosis were studied retrospectively. All patients had a histopathological confirm of the disease. 29 (61.7%) show a typical pulmonary pattern and 18 (38...
November 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29073511/differences-between-peritoneal-and-pleural-mesothelioma-in-lombardy-italy
#11
Carolina Mensi, Marco Mendola, Barbara Dallari, Maryam Sokooti, Ramin Tabibi, Luciano Riboldi, Dario Consonni
BACKGROUND: We examined characteristics of peritoneal (PEM) and pleural (PLM) mesothelioma in Lombardy, Italy. METHODS: From the Lombardy Mesothelioma Registry we selected PEM (N=300) and PLM (N=5011) cases diagnosed in 2000-2014. We investigated asbestos exposure and presence of asbestosis or pleural plaques. RESULTS: Incidence rates (per 1,000,000 person-years, world standardized) of PEM were 1.2 (men) and 0.9 (women), compared with 22.6 and 8...
October 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28855951/migrating-pleural-plaque-in-a-patient-with-asbestos-induced-pleural-disease-a-case-report
#12
Christian Eisenhawer, Michael K Felten, Thomas Hager, Mikhail Gronostayskiy, Philipp Bruners, Andrea Tannapfel, Thomas Kraus
BACKGROUND: Health surveillance of formerly asbestos exposed individuals focus on early detection of asbestos related diseases, such as lung fibrosis (asbestosis), pleural plaques, mesothelioma and lung cancer in particular. One main concern is the early and clear identification of lesions with a high risk of malignant changes and their undelayed clinical work-up. False positive results may lead to unnecessary and often painful diagnostic interventions, which create high costs when applied to a large cohort and also may discredit the whole program...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28707542/the-physiological-consequences-of-different-distributions-of-diffuse-pleural-thickening-on-ct-imaging
#13
Duneesha de Fonseka, Anthony Edey, Louise Stadon, Jason Viner, Michael Darby, Nick A Maskell
OBJECTIVE: Diffuse pleural thickening (DPT) refers to extensive visceral pleural fibrosis with adhesion formation to the parietal pleura obliterating the pleural space. The radiological definition of DPT remains controversial with most of the literature requiring the presence of an obliterated costophrenic angle (CPA) for defining DPT. We conducted a study to investigate the variable distributions of DPT and associated lung function deficit. METHODS: 85 patients referred to a pleural clinic with suspected pleural thickening were screened for our study...
August 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28686522/asbestos-related-disease-in-upholsterers
#14
M J Cruz, J Sampol, M Pallero, E Rodríguez, J Ferrer
Before its use was banned in developed countries, asbestos was widely applied in upholstery. However, the risk of asbestos diseases among upholsterers has only rarely been reported. In this case series, we present a first series of 6 workers employed in small workshops who developed several asbestos-related diseases, including pleural plaques, pleural fibrosis, and asbestosis. Exposures were intermittent and difficult to quantify, but lung asbestos content assessed by bronchoalveolar lavage was high in the 3 patients evaluated...
July 7, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28656146/incidental-and-underreported-pleural-plaques-at-chest-ct-do-not-miss-them-asbestos-exposure-still-exists
#15
Maria Antonietta Mazzei, Francesco Contorni, Francesco Gentili, Susanna Guerrini, Francesco Giuseppe Mazzei, Antonio Pinto, Nevada Cioffi Squitieri, Antonietta Gerardina Sisinni, Valentina Paolucci, Riccardo Romeo, Pietro Sartorelli, Luca Volterrani
Pleural plaques (PPs) may be a risk factor for mortality from lung cancer in asbestos-exposed workers and are considered to be a marker of exposure. Diagnosing PPs is also important because asbestos-exposed patients should be offered a health surveillance that is mandatory in many countries. On the other hand PPs are useful for compensation purposes. In this study we aimed to evaluate the prevalence, as incidental findings, and the underreporting rate of PPs in chest CT scans (CTs) performed in a cohort of patients (1512) who underwent chest CT with a slice thickness no more than 1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28641716/the-effects-of-pleural-plaques-on-longitudinal-lung-function-in-vermiculite-miners-of-libby-montana
#16
Kathleen A Clark, J Jay Flynn, Wilfried J J Karmaus, Lawrence C Mohr
BACKGROUND: This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor >1cm in diameter...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28558669/calretinin-as-a-blood-based-biomarker-for-mesothelioma
#17
Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W Musk, Bruce W S Robinson, Thomas Brüning, Jenette Creaney
BACKGROUND: Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbestos. Secondary prevention has been established to provide persons at risk regular health examinations. An earlier detection with tumor markers might improve therapeutic options. Previously, we have developed a new blood-based assay for the protein marker calretinin. Aim of this study was the verification of the assay in an independent study population and comparison with the established marker mesothelin...
May 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28515054/longitudinal-decline-in-lung-function-among-older-construction-workers
#18
John M Dement, Laura S Welch, Knut Ringen, Kim Cranford, Patricia Quinn
BACKGROUND: Occupational exposures to vapours, gasses, dusts and fumes (VGDF) and chest X-ray abnormalities by the International Labour Office (ILO) classification system are associated with reduced lung function, with the majority of published studies being cross-sectional. We examined the effects of VGDF exposures, as well as ILO parenchymal changes, pleural plaque and diffuse pleural thickening (DPT) on reduction in lung function in a longitudinal study. METHODS: Chest radiographs and spirometry for 3150 ageing construction workers enrolled in a medical screening programme with a baseline and at least one follow-up examination were studied...
October 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28498408/induction-of-il-17-production-from-human-peripheral-blood-cd4-cells-by-asbestos-exposure
#19
Megumi Maeda, Ying Chen, Suni Lee, Naoko Kumagai-Takei, Kei Yoshitome, Hidenori Matsuzaki, Shoko Yamamoto, Tamayo Hatayama, Miho Ikeda, Yasumitsu Nishimura, Takemi Otsuki
We have previously reported that chronic, recurrent and low-dose exposure to asbestos fibers causes a reduction in antitumor immunity. Investigation of natural killer (NK) cells using an in vitro cell line model and comprising in vitro activation using freshly isolated NK cells co-cultured with chrysotile fibers, as well as NK cells derived from asbestos-exposed patients with pleural plaque (PP) or malignant mesothelioma (MM), revealed decreased expression of NK cell activating receptors such as NKG2D, 2B4 and NKp46...
May 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28491491/tuberculous-pleural-effusion-occurring-concurrently-with-asbestos-related-pleural-disease
#20
Massa Zantah, Debapriya Datta
An eighty-four-year-old man presented with progressive exertional dyspnea, productive cough and weight loss for two months. His physical exam was notable for diminished breath sounds at the right base, with dullness to percussion. Chest-x-ray showed moderate right-sided pleural effusion and bilateral calcified pleural plaques as well as diaphragmatic plaques consistent with asbestos-related pleural disease (ARPD). Pleural fluid was exudative with predominantly mononuclear cells, negative acid fast bacilli stain, negative cultures, and negative cytology for malignant cells...
2017: Respiratory Medicine Case Reports
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