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Clinical prediction rules

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https://www.readbyqxmd.com/read/29474322/validation-of-a-novel-molecular-host-response-assay-to-diagnose-infection-in-hospitalized-patients-admitted-to-the-icu-with-acute-respiratory-failure
#1
Maria E Koster-Brouwer, Diana M Verboom, Brendon P Scicluna, Kirsten van de Groep, Jos F Frencken, Davy Janssen, Rob Schuurman, Marcus J Schultz, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
OBJECTIVES: Discrimination between infectious and noninfectious causes of acute respiratory failure is difficult in patients admitted to the ICU after a period of hospitalization. Using a novel biomarker test (SeptiCyte LAB), we aimed to distinguish between infection and inflammation in this population. DESIGN: Nested cohort study. SETTING: Two tertiary mixed ICUs in the Netherlands. PATIENTS: Hospitalized patients with acute respiratory failure requiring mechanical ventilation upon ICU admission from 2011 to 2013...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29471111/mortality-prediction-in-intensive-care-units-icus-using-a-deep-rule-based-fuzzy-classifier
#2
Raheleh Davoodi, Mohammad Hassan Moradi
Electronic health records (EHRs) contain critical information useful for clinical studies. Early assessment of patients' mortality in intensive care units is of great importance. In this paper, a Deep Rule-Based Fuzzy System (DRBFS) was proposed to develop an accurate in-hospital mortality prediction in the intensive care unit (ICU) patients employing a large number of input variables. Our main contribution is proposing a system, which is capable of dealing with big data with heterogeneous mixed categorical and numeric attributes...
February 19, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29468000/an-accurate-diagnostic-pathway-helps-to-correctly-distinguish-between-the-possible-causes-of-acute-scrotum
#3
Beat Roth, Ioannis Giannakis, Meret Elisabeth Ricklin, George Niklaus Thalmann, Aristomenis Konstantinos Exadaktylos
Objectives: We sought to identify a simplified approach for the rapid differential diagnosis of patients presenting with acute scrotum. Methods: A total of 440 patients referred to the emergency department of the University Hospital of Bern, Switzerland, with acute scrotum between 2003 and 2013 were retrospectively analyzed. Simple and multiple binary logistic regression analyses were used to evaluate clinical and laboratory parameters that may help to distinguish between genital/paragenital infection and acute testicular torsion...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29461647/comparison-of-three-dehydration-scales-showed-that-they-were-of-limited-or-no-value-for-assessing-small-children-with-acute-diarrhoea
#4
Dominika Pomorska, Piotr Dziechciarz, Esto Mduma, Joshua Gidion, Anna Falszewska, Hania Szajewska
AIM: We explored the diagnostic accuracy of the Clinical Dehydration Scale (CDS), the World Health Organization (WHO) scale and the Gorelick scale for assessing dehydration in children admitted to a Tanzanian referral hospital. METHODS: This was a prospective, observational study, carried out from April 2015 to January 2017 on children aged one month to five years admitted to the hospital with acute diarrhoea lasting less than five days. Before rehydration therapy, each patient's weight was recorded and the degree of dehydration was assessed based on the three scales...
February 20, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29455373/diagnostic-value-of-ultrasonography-for-the-detection-of-disc-displacements-in-the-temporomandibular-joint-a-systematic-review-and-meta-analysis
#5
Naichuan Su, Arjen J van Wijk, Corine M Visscher, Frank Lobbezoo, Geert J M G van der Heijden
OBJECTIVES: The aim was to assess the added diagnostic value of ultrasonography (US) for establishing the presence or absence of disc displacements (DDs) in temporomandibular joints (TMJs). MATERIALS AND METHODS: Pubmed and EMBASE were searched electronically to identify diagnostic accuracy studies that assessed the diagnostic value of US for the diagnosis of DD, using Magnetic resonance imaging (MRI) as the reference standard. Meta-analyses were performed with Metadisc 1...
February 17, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29452747/accuracy-of-clinician-practice-compared-with-three-head-injury-decision-rules-in-children-a-prospective-cohort-study
#6
Franz E Babl, Ed Oakley, Stuart R Dalziel, Meredith L Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Susan Donath, Stephen Hearps, Charlotte Molesworth, Louise Crowe, Silvia Bressan, Mark D Lyttle
STUDY OBJECTIVE: Three clinical decision rules for head injuries in children (Pediatric Emergency Care Applied Research Network [PECARN], Canadian Assessment of Tomography for Childhood Head Injury [CATCH], and Children's Head Injury Algorithm for the Prediction of Important Clinical Events [CHALICE]) have been shown to have high performance accuracy. The utility of any of these in a particular setting depends on preexisting clinician accuracy. We therefore assess the accuracy of clinician practice in detecting clinically important traumatic brain injury...
February 13, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29450817/prediction-of-neonatal-hyperbilirubinemia-using-1st-day-serum-bilirubin-levels
#7
S M Spoorthi, Siddappa F Dandinavar, Vinod H Ratageri, Prakash K Wari
The study was conducted on Full term neonates with birth weight > 2.5 kg born in KIMS, Hubballi with an objective to determine the first day Total Serum Bilirubin (TSB) value so as to predict subsequent development of significant hyperbilirubinemia in term neonates. All enrolled neonates were sampled for TSB and blood group on Day 1 at 20 ± 4 h and then followed up clinically by Kramer's rule and when the clinical jaundice by Kramer's rule was >10 mg/dl, TSB levels were repeated. A total of 180 newborns were enrolled for the study and 165 babies completed the study...
February 15, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29450510/utility-of-a-clinical-prediction-rule-to-exclude-pulmonary-embolism-among-low-risk-emergency-department-patients-reason-to-perc-up
#8
Jeffrey A Kline
No abstract text is available yet for this article.
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29449279/mri-with-dwi-for-the-detection-of-posttreatment-head-and-neck-squamous-cell-carcinoma-why-morphologic-mri-criteria-matter
#9
A Ailianou, P Mundada, T De Perrot, M Pusztaszieri, P-A Poletti, M Becker
BACKGROUND AND PURPOSE: Although diffusion-weighted imaging combined with morphologic MRI (DWIMRI) is used to detect posttreatment recurrent and second primary head and neck squamous cell carcinoma, the diagnostic criteria used so far have not been clarified. We hypothesized that precise MRI criteria based on signal intensity patterns on T2 and contrast-enhanced T1 complement DWI and therefore improve the diagnostic performance of DWIMRI. MATERIALS AND METHODS: We analyzed 1...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29447696/strain-tracking-reveals-the-determinants-of-bacterial-engraftment-in-the-human-gut-following-fecal-microbiota-transplantation
#10
Christopher S Smillie, Jenny Sauk, Dirk Gevers, Jonathan Friedman, Jaeyun Sung, Ilan Youngster, Elizabeth L Hohmann, Christopher Staley, Alexander Khoruts, Michael J Sadowsky, Jessica R Allegretti, Mark B Smith, Ramnik J Xavier, Eric J Alm
Fecal microbiota transplantation (FMT) from healthy donor to patient is a treatment for microbiome-associated diseases. Although the success of FMT requires donor bacteria to engraft in the patient's gut, the forces governing engraftment in humans are unknown. Here we use an ongoing clinical experiment, the treatment of recurrent Clostridium difficile infection, to uncover the rules of engraftment in humans. We built a statistical model that predicts which bacterial species will engraft in a given host, and developed Strain Finder, a method to infer strain genotypes and track them over time...
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29446860/development-of-a-clinical-prediction-rule-for-tuberculous-meningitis-in-adults-in-lima-peru
#11
Lely Solari, Alonso Soto, Patrick van der Stuyft
OBJECTIVES: Diagnosis of Tuberculous Meningitis (TM) is a challenge in countries with a high burden of the disease and constrained resources and Clinical Prediction Rules (CPRs) could be of assistance. We aimed at developing a CPR for diagnosis of TM in a Latin American setting with high tuberculosis incidence and a concentrated HIV epidemic. METHODS: We enrolled adult patients with clinical suspicion of TM attending two hospitals in Lima, Peru. We obtained information on potential anamnestic, clinical and laboratory predictive findings that are easy to collect and promptly available...
February 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29444553/evaluation-of-biomarkers-for-treatment-selection-using-individual-participant-data-from-multiple-clinical-trials
#12
Chaeryon Kang, Holly Janes, Parvin Tajik, Henk Groen, Ben Mol, Corine Koopmans, Kim Broekhuijsen, Eva Zwertbroek, Maria van Pampus, Maureen Franssen
Biomarkers that predict treatment effects may be used to guide treatment decisions, thus improving patient outcomes. A meta-analysis of individual participant data (IPD) is potentially more powerful than a single-study data analysis in evaluating markers for treatment selection. Our study was motivated by the IPD that were collected from 2 randomized controlled trials of hypertension and preeclampsia among pregnant women to evaluate the effect of labor induction over expectant management of the pregnancy in preventing progression to severe maternal disease...
February 14, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29439059/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#13
Isabel Amendoeira, Tiago Maia, M Sobrinho-Simões
The 2017 edition of the WHO book on Classification of Tumours of Endocrine Organs includes a new section entitled "Other encapsulated follicular-patterned thyroid tumours", in which the newly created NIFTP (Non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is identified and detailed described. Despite deleting the word "carcinoma" from its name, NIFTP is not a benign tumor either, and is best regarded as a neoplasm with "very low malignant potential"...
February 9, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29437755/a-diagnostic-cohort-study-on-the-accuracy-of-18-fluorodeoxyglucose-18-fdg-positron-emission-tomography-pet-ct-for-evaluation-of-malignancy-in-anterior-mediastinal-lesions-the-decimal-study
#14
Chiara Proli, Paulo De Sousa, Simon Jordan, Vladimir Anikin, Anand Devaraj, Susannah M Love, Michael Shackcloth, Nikolaos Kostoulas, Kostas Papagiannopoulos, Yama Haqzad, Mahmoud Loubani, Francesco Sellitri, Felice Granato, Alexander Bush, Adrian Marchbank, Swetha Iyer, Marco Scarci, Eric Lim
OBJECTIVES: The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass SETTING: DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29435442/the-carpediem-algorithm-a-rule-based-system-for-identifying-heart-failure-phenotype-with-a-precision-public-health-approach
#15
Michela Franchini, Stefania Pieroni, Claudio Passino, Michele Emdin, Sabrina Molinaro
Modern medicine remains dependent on the accurate evaluation of a patient's health state, recognizing that disease is a process that evolves over time and interacts with many factors unique to that patient. The CARPEDIEM project represents a concrete attempt to address these issues by developing reproducible algorithms to support the accuracy in detection of complex diseases. This study aims to establish and validate the CARPEDIEM approach and algorithm for identifying those patients presenting with or at risk of heart failure (HF) by studying 153,393 subjects in Italy, based on patient information flow databases and is not reliant on the electronic health record to accomplish its goals...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29433793/correlation-between-sma-type-and-smn2-copy-number-revisited-an-analysis-of-625-unrelated-spanish-patients-and-a-compilation-of-2834-reported-cases
#16
Maite Calucho, Sara Bernal, Laura Alías, Francesca March, Adoración Venceslá, Francisco J Rodríguez-Álvarez, Elena Aller, Raquel M Fernández, Salud Borrego, José M Millán, Concepción Hernández-Chico, Ivon Cuscó, Pablo Fuentes-Prior, Eduardo F Tizzano
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss or mutations in SMN1. According to age of onset, achieved motor abilities, and life span, SMA patients are classified into type I (never sit), II (never walk unaided) or III (achieve independent walking abilities). SMN2, the highly homologous copy of SMN1, is considered the most important phenotypic modifier of the disease. Determination of SMN2 copy number is essential to establish careful genotype-phenotype correlations, predict disease evolution, and to stratify patients for clinical trials...
January 11, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29431200/gata-3-staining-in-primary-cutaneous-apocrine-cribriform-carcinoma-usefulness-to-differentiate-it-from-breast-cancer-metastasis
#17
M Llamas-Velasco, Y C Pérez-Gónzalez, E Daudén, A Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raise a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. DESIGN: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test this immunostaining usefulness to differentiate this tumor from metastatic breast cancer...
February 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29427301/prospective-validation-and-refinement-of-a-decision-rule-to-obtain-cxr-in-patients-with-non-traumatic-chest-pain-in-the-ed
#18
Case Newsom, Rebecca Jeanmonod, Wendy Woolley, Nirali Shah, Shellie Asher, Eric Bruno, Michael Silberman, Mark Reiter, Donald Jeanmonod
OBJECTIVES: To prospectively validate and refine previously published criteria to determine the potential utility of chest x-ray (CXR) in the evaluation and management of patients presenting to the emergency department (ED) with non-traumatic chest pain. METHODS: A prospective observational study was performed of patients presenting to three EDs in the US with a chief complaint of non-traumatic chest pain. Previously defined high-risk history and exam elements were combined into a refined decision rule and these elements were recorded for each patient by the ED physician...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29427011/self-learning-computers-for-surgical-planning-and-prediction-of-postoperative-alignment
#19
Renaud Lafage, Sébastien Pesenti, Virginie Lafage, Frank J Schwab
PURPOSE: In past decades, the role of sagittal alignment has been widely demonstrated in the setting of spinal conditions. As several parameters can be affected, identifying the driver of the deformity is the cornerstone of a successful treatment approach. Despite the importance of restoring sagittal alignment for optimizing outcome, this task remains challenging. Self-learning computers and optimized algorithms are of great interest in spine surgery as in that they facilitate better planning and prediction of postoperative alignment...
February 9, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29426039/prohormones-in-the-early-diagnosis-of-cardiac-syncope
#20
Patrick Badertscher, Thomas Nestelberger, Jeanne du Fay de Lavallaz, Martin Than, Beata Morawiec, Damian Kawecki, Òscar Miró, Beatriz López, F Javier Martin-Sanchez, José Bustamante, Nicolas Geigy, Michael Christ, Salvatore Di Somma, W Frank Peacock, Louise Cullen, François Sarasin, Dayana Flores, Michael Tschuck, Jasper Boeddinghaus, Raphael Twerenbold, Karin Wildi, Zaid Sabti, Christian Puelacher, Maria Rubini Giménez, Nikola Kozhuharov, Samyut Shrestha, Ivo Strebel, Katharina Rentsch, Dagmar I Keller, Imke Poepping, Andreas Buser, Wanda Kloos, Jens Lohrmann, Michael Kuehne, Stefan Osswald, Tobias Reichlin, Christian Mueller
BACKGROUND: The early detection of cardiac syncope is challenging. We aimed to evaluate the diagnostic value of 4 novel prohormones, quantifying different neurohumoral pathways, possibly involved in the pathophysiological features of cardiac syncope: midregional-pro-A-type natriuretic peptide (MRproANP), C-terminal proendothelin 1, copeptin, and midregional-proadrenomedullin. METHODS AND RESULTS: We prospectively enrolled unselected patients presenting with syncope to the emergency department (ED) in a diagnostic multicenter study...
December 14, 2017: Journal of the American Heart Association
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